diclofenac etalhyaluronate sodium 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
5489 1398396-25-2

Description:

MoleculeDescription

Molfile

Synonyms:

  • diclofenac etalhyaluronate sodium
  • joycle
  • SI-613
  • ONO 5704
  • ONO-5704/SI-613
Diclofenac etalhyaluronate is a 130,000 kDa compound in which the diclofenac molecule is attached via a 2-aminoethanol linker to the glucuronic acid moiety of the hyaluronic acid. Diclofenac is released through hydrolytic cleavage of the ester linkage and it inhibits the synthesis of prostaglandin E2.
  • Molecular weight:
  • Formula: H2O(C30H35Cl2N3O12)a(C14H20NO11)b
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA:
  • ALOGS:
  • ROTB: None

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
March 23, 2021 PMDA Seikagaku Corporation

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

None

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Osteoarthritis of hip indication 239872002
Osteoarthritis of knee indication 239873007




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Prostaglandin E2 receptor EP2 subtype GPCR UNKNOWN DRUG LABEL

External reference:

IDSource
CHEMBL4297232 ChEMBL_ID
C000656259 MESH_SUPPLEMENTAL_RECORD_UI
LG1II3835L UNII
D11020 KEGG_DRUG
C5420904 UMLSCUI
CHEMBL4297231 ChEMBL_ID

Pharmaceutical products:

None