peficitinib 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| Janus kinase inhibitors, antineoplastics | 5481 | 944118-01-8 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
Peficitinib inhibits the signal transduction of cytokines important for the pathological condition of RA as it inhibits the kinase activity of the JAK family (JAK1, JAK2, JAK3, and TYK2) and their signal transduction mediated by IL-2.
|
Drug dosage:
None
ADMET properties:
None
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| March 26, 2019 | PMDA | ASTELLAS PHARMA |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | L04AA49 | ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS IMMUNOSUPPRESSANTS IMMUNOSUPPRESSANTS Selective immunosuppressants |
| MeSH PA | D004791 | Enzyme Inhibitors |
| MeSH PA | D007155 | Immunologic Factors |
| MeSH PA | D007166 | Immunosuppressive Agents |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Rheumatoid arthritis | indication | 69896004 | DOID:7148 |
| Hepatic failure | contraindication | 59927004 | |
| Pregnancy | contraindication | 289908002 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
None
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Tyrosine-protein kinase JAK3 | Kinase | INHIBITOR | IC50 | 9.15 | DRUG LABEL | DRUG LABEL | |||
| Tyrosine-protein kinase JAK1 | Kinase | INHIBITOR | IC50 | 8.41 | DRUG LABEL | DRUG LABEL | |||
| Tyrosine-protein kinase JAK2 | Kinase | INHIBITOR | IC50 | 8.30 | DRUG LABEL | DRUG LABEL | |||
| Non-receptor tyrosine-protein kinase TYK2 | Kinase | INHIBITOR | IC50 | 8.32 | DRUG LABEL | DRUG LABEL |
External reference:
| ID | Source |
|---|---|
| HPH1166CKX | UNII |
| 1353219-05-2 | SECONDARY_CAS_RN |
| C4505522 | UMLSCUI |
| 9T6 | PDB_CHEM_ID |
| CHEMBL3137308 | ChEMBL_ID |
| 57928403 | PUBCHEM_CID |
| DB11708 | DRUGBANK_ID |
| CHEMBL3137329 | ChEMBL_ID |
| 9910 | INN_ID |
| 8315 | IUPHAR_LIGAND_ID |
| D10653 | KEGG_DRUG |
| C000608065 | MESH_SUPPLEMENTAL_RECORD_UI |
Pharmaceutical products:
None