ansuvimab 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
antiviral, monoclonal antibodies	5433	2375952-29-5

Description:

Molecule	Description
Molfile Synonyms: ansuvimab ansuvimab-zykl mAb114 VRC-EBOMAB092-00-AB EboV mAb114 ebanga	EBANGA (ansuvimab-zykl) is a Zaire ebolavirus (EBOV) glycoprotein 1 (GP1)-directed recombinant, human IgG1kappa monoclonal antibody that binds to the glycan cap and inner chalice of the EBOV GP1 subunit. The epitope to which it binds is located within the receptor binding domain of EBOV consisting of amino acids LEIKKPDGS (GP residues 111–119). Molecular weight: Formula: CLOGP: LIPINSKI: None HAC: None HDO: None TPSA: ALOGS: ROTB: None

Molecule

Description

Molfile

Synonyms:

ansuvimab
ansuvimab-zykl
mAb114
VRC-EBOMAB092-00-AB
EboV mAb114
ebanga

EBANGA (ansuvimab-zykl) is a Zaire ebolavirus (EBOV) glycoprotein 1 (GP1)-directed recombinant, human IgG1kappa monoclonal antibody that binds to the glycan cap and inner chalice of the EBOV GP1 subunit. The epitope to which it binds is located within the receptor binding domain of EBOV consisting of amino acids LEIKKPDGS (GP residues 111–119).

Molecular weight:
Formula:
CLOGP:
LIPINSKI: None
HAC: None
HDO: None
TPSA:
ALOGS:
ROTB: None

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
Dec. 21, 2020	FDA	RIDGEBACK BIOTHERAPEUTICS

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	J06BD04	ANTIINFECTIVES FOR SYSTEMIC USE IMMUNE SERA AND IMMUNOGLOBULINS IMMUNOGLOBULINS Antiviral monoclonal antibodies
MeSH PA	D000890	Anti-Infective Agents
MeSH PA	D000998	Antiviral Agents
FDA MoA	N0000194037	Zaire Ebolavirus Glycoprotein-directed Antibody Interactions
FDA EPC	N0000194038	Zaire Ebolavirus Glycoprotein-directed Antibody

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Ebola virus disease	indication	37109004	DOID:4325

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Envelope glycoprotein	Glycoprotein		VGP_EBOZ5	ANTIBODY BINDING	Kd	9.70		DRUG LABEL	DRUG LABEL

External reference:

ID	Source
D11875	KEGG_DRUG
TG8IQ19NG2	UNII
C5432324	UMLSCUI
CHEMBL4594388	ChEMBL_ID
DB16385	DRUGBANK_ID
018606	NDDF
1149150009	SNOMEDCT_US
1149244009	SNOMEDCT_US
2472151	RXNORM
C000711947	MESH_SUPPLEMENTAL_RECORD_UI
11568	INN_ID

Pharmaceutical products:

None