Stem definition | Drug id | CAS RN |
---|---|---|
antibiotics, cefalosporanic acid derivatives | 542 | 61270-58-4 |
Dose | Unit | Route |
---|---|---|
1 | g | P |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 3 | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 99 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 30.78 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
Vd (Volume of distribution) | 0.14 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 0.38 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.02 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 5.10 hours | Lombardo F, Berellini G, Obach RS |
S (Water solubility) | 100 mg/mL | Bocci G, Oprea TI, Benet LZ |
Date | Agency | Company | Orphan |
---|---|---|---|
None | FDA | GLAXOSMITHKLINE |
None
None
None
None
Source | Code | Description |
---|---|---|
ATC | J01DC06 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIBACTERIALS FOR SYSTEMIC USE OTHER BETA-LACTAM ANTIBACTERIALS Second-generation cephalosporins |
CHEBI has role | CHEBI:36047 | antibacterial drugs |
MeSH PA | D000900 | Anti-Bacterial Agents |
MeSH PA | D000890 | Anti-Infective Agents |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Septicemia due to Escherichia coli | indication | 9323009 | |
Bacterial septicemia | indication | 10001005 | DOID:0040085 |
Infection of skin AND/OR subcutaneous tissue | indication | 19824006 | |
Streptococcal septicemia | indication | 29577008 | |
Pneumonia due to Streptococcus | indication | 34020007 | |
Lower respiratory tract infection | indication | 50417007 | |
Pneumonia due to Escherichia coli | indication | 51530003 | |
Klebsiella cystitis | indication | 60867007 | |
Urinary tract infectious disease | indication | 68566005 | |
Haemophilus influenzae pneumonia | indication | 70036007 | |
Infection of bone | indication | 111253001 | |
Bacterial infection due to Klebsiella pneumoniae | indication | 186435004 | |
Pneumonia | indication | 233604007 | DOID:552 |
Escherichia coli urinary tract infection | indication | 301011002 | |
Proteus urinary tract infection | indication | 301012009 | |
Streptococcus pyogenes infection | indication | 302809008 | |
Infectious disorder of joint | indication | 363162000 | |
Infection due to Staphylococcus aureus | indication | 406602003 | |
Osteomyelitis due to Staphylococcus aureus | indication | 428783003 | |
Skin and Skin Structure Streptococcus Agalactiae Infection | indication | ||
Morganella Morganii Urinary Tract Infection | indication | ||
Staphylococcus Epidermidis Skin and Skin Structure Infection | indication | ||
Prosthetic Arthroplasty Infection Prevention | indication | ||
Providencia Urinary Tract Infection | indication | ||
Prevention of Perioperative Infection | indication |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 2.63 | acidic |
pKa2 | 11.72 | acidic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Prostaglandin G/H synthase 2 | Enzyme | IC50 | 4.48 | WOMBAT-PK | |||||
Matrix metalloproteinase-9 | Enzyme | IC50 | 5.04 | WOMBAT-PK | |||||
Somatostatin receptor type 4 | GPCR | IC50 | 4.24 | WOMBAT-PK | |||||
Bacterial penicillin-binding protein | Enzyme | INHIBITOR | CHEMBL | CHEMBL | |||||
Penicillin-binding protein 1A | Enzyme | WOMBAT-PK |
ID | Source |
---|---|
4019661 | VUID |
N0000147753 | NUI |
D00912 | KEGG_DRUG |
2183 | RXNORM |
C0007551 | UMLSCUI |
CHEBI:3491 | CHEBI |
CHEMBL1601 | ChEMBL_ID |
CHEMBL1201005 | ChEMBL_ID |
D015790 | MESH_DESCRIPTOR_UI |
DB01328 | DRUGBANK_ID |
12217 | IUPHAR_LIGAND_ID |
4479 | INN_ID |
61270-78-8 | SECONDARY_CAS_RN |
6532B86WFG | UNII |
43594 | PUBCHEM_CID |
1008 | MMSL |
1887 | MMSL |
4376 | MMSL |
d00063 | MMSL |
35343004 | SNOMEDCT_US |
370353006 | SNOMEDCT_US |
58343005 | SNOMEDCT_US |
4018011 | VANDF |
4019661 | VANDF |
002732 | NDDF |
004848 | NDDF |
None