imlifidase 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
enzymes 5418 1947415-68-0

Description:

MoleculeDescription

Molfile

Synonyms:

  • imlifidase
  • idefirix
  • HMED-IdeS
  • IdeS
Imlifidase is a cysteine protease derived from the immunoglobulin G (IgG)-degrading enzyme of Streptococcus pyogenes that cleaves the heavy chains of all human IgG subclasses but no other immunoglobulins. The cleavage of IgG leads to elimination of Fc-dependent effector functions, including CDC and antibody- dependent cell-mediated cytotoxicity (ADCC). By cleaving all IgG, imlifidase reduces the level of DSA, thus enabling transplantation.
  • Molecular weight:
  • Formula:
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA:
  • ALOGS:
  • ROTB: None

Drug dosage:

DoseUnitRoute
17.50 mg P

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Aug. 26, 2020 EMA Hansa Biopharma AB

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC L04AA41 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
IMMUNOSUPPRESSANTS
IMMUNOSUPPRESSANTS
Selective immunosuppressants

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Transplant of kidney indication 70536003
Renal transplant rejection indication 236570004
Thrombotic thrombocytopenic purpura contraindication 78129009 DOID:10772




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Immunoglobulin gamma (IgG), heavy chain Antibody INHIBITOR SCIENTIFIC LITERATURE SCIENTIFIC LITERATURE

External reference:

IDSource
D11470 KEGG_DRUG
UVJ7NL8S2P UNII
C5139878 UMLSCUI
CHEMBL4297981 ChEMBL_ID
DB15258 DRUGBANK_ID
018684 NDDF
10617 INN_ID

Pharmaceutical products:

None