pemigatinib Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
tyrosine kinase inhibitors 5390 1513857-77-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • pemigatinib
  • pemazyre
  • INCB054828
Pemigatinib inhibited FGFR1-3 phosphorylation and signaling and decreased cell viability in cancer cell lines with activating FGFR amplifications and fusions that resulted in constitutive activation of FGFR signaling
  • Molecular weight: 487.51
  • Formula: C24H27F2N5O4
  • CLOGP: 2.73
  • LIPINSKI: 0
  • HAC: 9
  • HDO: 1
  • TPSA: 83.16
  • ALOGS: -3.53
  • ROTB: 6

  • Status: ONP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
April 17, 2020 FDA INCYTE CORP

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

None

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Malignant neoplasm of common bile duct (& [carcinoma]) indication 187785004

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 4.44 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Fibroblast growth factor receptor 3 Kinase INHIBITOR IC50 9 SCIENTIFIC LITERATURE DRUG LABEL
Fibroblast growth factor receptor 1 Kinase INHIBITOR IC50 9.40 SCIENTIFIC LITERATURE DRUG LABEL
Fibroblast growth factor receptor 2 Kinase INHIBITOR IC50 9.30 SCIENTIFIC LITERATURE DRUG LABEL
Fibroblast growth factor receptor 4 Kinase INHIBITOR IC50 7.52 SCIENTIFIC LITERATURE

External reference:

IDSource
86705695 PUBCHEM_CID
Y6BX7BL23K UNII
10712 INN_ID
DB15102 DRUGBANK_ID
CHEMBL4297522 ChEMBL_ID
D11417 KEGG_DRUG
9767 IUPHAR_LIGAND_ID
C000705477 MESH_SUPPLEMENTAL_RECORD_UI

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
PEMAZYRE HUMAN PRESCRIPTION DRUG LABEL 1 50881-026 TABLET 4.50 mg ORAL NDA 17 sections
PEMAZYRE HUMAN PRESCRIPTION DRUG LABEL 1 50881-027 TABLET 9 mg ORAL NDA 17 sections
PEMAZYRE HUMAN PRESCRIPTION DRUG LABEL 1 50881-028 TABLET 13.50 mg ORAL NDA 17 sections