pemigatinib Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| tyrosine kinase inhibitors | 5390 | 1513857-77-6 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
Pemigatinib inhibited FGFR1-3 phosphorylation and signaling and decreased cell viability in cancer cell lines with activating FGFR amplifications and fusions that resulted in constitutive activation of FGFR signaling
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
None
ADMET properties:
None
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| April 17, 2020 | FDA | INCYTE CORP |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
Pharmacologic Action:
None
Drug Use (View source of the data)
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Malignant neoplasm of common bile duct (& [carcinoma]) | indication | 187785004 |
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 4.44 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Fibroblast growth factor receptor 3 | Kinase | INHIBITOR | IC50 | 9 | SCIENTIFIC LITERATURE | DRUG LABEL | |||
| Fibroblast growth factor receptor 1 | Kinase | INHIBITOR | IC50 | 9.40 | SCIENTIFIC LITERATURE | DRUG LABEL | |||
| Fibroblast growth factor receptor 2 | Kinase | INHIBITOR | IC50 | 9.30 | SCIENTIFIC LITERATURE | DRUG LABEL | |||
| Fibroblast growth factor receptor 4 | Kinase | INHIBITOR | IC50 | 7.52 | SCIENTIFIC LITERATURE |
External reference:
| ID | Source |
|---|---|
| 86705695 | PUBCHEM_CID |
| Y6BX7BL23K | UNII |
| 10712 | INN_ID |
| DB15102 | DRUGBANK_ID |
| CHEMBL4297522 | ChEMBL_ID |
| D11417 | KEGG_DRUG |
| 9767 | IUPHAR_LIGAND_ID |
| C000705477 | MESH_SUPPLEMENTAL_RECORD_UI |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| PEMAZYRE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50881-026 | TABLET | 4.50 mg | ORAL | NDA | 17 sections |
| PEMAZYRE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50881-027 | TABLET | 9 mg | ORAL | NDA | 17 sections |
| PEMAZYRE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50881-028 | TABLET | 13.50 mg | ORAL | NDA | 17 sections |