cefmenoxime 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
antibiotics, cefalosporanic acid derivatives	538	65085-01-0

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: cefmenoxime hydrochloride cefmenoxime cefmenoxime HCl	A cephalosporin antibiotic that is administered intravenously or intramuscularly. It is active against most common gram-positive and gram-negative microorganisms, is a potent inhibitor of Enterobacteriaceae, and is highly resistant to hydrolysis by beta-lactamases. The drug has a high rate of efficacy in many types of infection and to date no severe side effects have been noted. Molecular weight: 511.55 Formula: C16H17N9O5S3 CLOGP: 0.32 LIPINSKI: 2 HAC: 14 HDO: 3 TPSA: 190.81 ALOGS: -3.06 ROTB: 8 Status: OFM Legend: OFP - off patent OFM - off market ONP - on patent

Molecule

Description

Molfile Inchi Smiles

Synonyms:

cefmenoxime hydrochloride
cefmenoxime
cefmenoxime HCl

A cephalosporin antibiotic that is administered intravenously or intramuscularly. It is active against most common gram-positive and gram-negative microorganisms, is a potent inhibitor of Enterobacteriaceae, and is highly resistant to hydrolysis by beta-lactamases. The drug has a high rate of efficacy in many types of infection and to date no severe side effects have been noted.

Molecular weight: 511.55
Formula: C16H17N9O5S3
CLOGP: 0.32
LIPINSKI: 2
HAC: 14
HDO: 3
TPSA: 190.81
ALOGS: -3.06
ROTB: 8

Status: OFM

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

Dose	Unit	Route
2	g	P

ADMET properties:

Property	Value	Reference
MRTD (Maximum Recommended Therapeutic Daily Dose)	130.38 µM/kg/day	Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BDDCS (Biopharmaceutical Drug Disposition Classification System)	3	Hosey CM, Chan R, Benet LZ
Vd (Volume of distribution)	0.20 L/kg	Lombardo F, Berellini G, Obach RS
CL (Clearance)	3.65 mL/min/kg	Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma)	0.31 %	Lombardo F, Berellini G, Obach RS
t_half (Half-life)	0.89 hours	Lombardo F, Berellini G, Obach RS
S (Water solubility)	0.45 mg/mL	Bocci G, Oprea TI, Benet LZ

Approvals:

Date	Agency	Company	Orphan
Dec. 30, 1987	FDA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	J01DD05	ANTIINFECTIVES FOR SYSTEMIC USE ANTIBACTERIALS FOR SYSTEMIC USE OTHER BETA-LACTAM ANTIBACTERIALS Third-generation cephalosporins
ATC	S01AA31	SENSORY ORGANS OPHTHALMOLOGICALS ANTIINFECTIVES Antibiotics
ATC	S02AA18	SENSORY ORGANS OTOLOGICALS ANTIINFECTIVES Antiinfectives
CHEBI has role	CHEBI:36047	antibacterial drugs
MeSH PA	D000900	Anti-Bacterial Agents
MeSH PA	D000890	Anti-Infective Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	2.5	acidic
pKa2	13.31	acidic
pKa3	3.23	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Bacterial penicillin-binding protein	Enzyme		PBPA_ECOLI PBPB_ECOLI DACC_ECOLI PBP2_ECOLI FTSI_ECOLI DACA_ECOLI DACB_ECOLI	INHIBITOR				CHEMBL	CHEMBL

External reference:

ID	Source
D01739	KEGG_DRUG
75738-58-8	SECONDARY_CAS_RN
C0007549	UMLSCUI
CHEBI:55490	CHEBI
CHEMBL1201224	ChEMBL_ID
CHEMBL3183193	ChEMBL_ID
D015281	MESH_DESCRIPTOR_UI
DB00267	DRUGBANK_ID
12024	IUPHAR_LIGAND_ID
4930	INN_ID
KBZ4844CXN	UNII
9570757	PUBCHEM_CID
006821	NDDF
006822	NDDF

Pharmaceutical products:

None