eptinezumab Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
humanized origin 5386 1644539-04-7

Description:

MoleculeDescription

Synonyms:

  • eptinezumab
  • eptinezumab-jjmr
  • vyepti
  • ALD403
Eptinezumab-jjmr is a humanized monoclonal antibody that binds to calcitonin gene-related peptide (CGRP) ligand and blocks its binding to the receptor
  • Molecular weight:
  • Formula:
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA:
  • ALOGS:
  • ROTB: None

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Feb. 21, 2020 FDA Lundbeck Seattle BioPharmaceuticals, Inc.

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

None

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Migraine indication 37796009 DOID:6364

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Calcitonin gene-related peptide 1 GPCR BINDING AGENT Kd 10.82 DRUG LABEL DRUG LABEL
Calcitonin gene-related peptide 2 GPCR BINDING AGENT Kd 10.24 DRUG LABEL DRUG LABEL

External reference:

IDSource
4039215 VANDF
4039216 VANDF
C4743169 UMLSCUI
CHEMBL2109621 ChEMBL_ID
CHEMBL3833320 ChEMBL_ID
DB14040 DRUGBANK_ID
C000628361 MESH_SUPPLEMENTAL_RECORD_UI
D11303 KEGG_DRUG
10694 IUPHAR_LIGAND_ID
10308 INN_ID
8202AY8I7H UNII
2282660 RXNORM
331473 MMSL
38197 MMSL
d09520 MMSL
018285 NDDF
870524004 SNOMEDCT_US
871787004 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Vyepti HUMAN PRESCRIPTION DRUG LABEL 1 67386-130 INJECTION 100 mg INTRAVENOUS BLA 24 sections