remdesivir Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| antivirals | 5376 | 1809249-37-3 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
Remdesivir is an investigational nucleotide analog with broad-spectrum antiviral activity. Remdesivir has demonstrated in vitro and in vivo activity in animal models against the viral pathogens MERS and SARS, which are also coronaviruses and are structurally similar to COVID-19. The limited preclinical data on remdesivir in MERS and SARS indicate that remdesivir may have potential activity against COVID-19
|
Drug dosage:
None
ADMET properties:
None
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| CHEBI has role | CHEBI:36044 | antiviral drug |
| CHEBI has role | CHEBI:50266 | prodrug |
| MeSH PA | D000890 | Anti-Infective Agents |
| MeSH PA | D000963 | Antimetabolites |
| MeSH PA | D000998 | Antiviral Agents |
| MeSH PA | D009676 | Noxae |
Drug Use (View source of the data)
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Coronavirus infection | off-label use | 186747009 |
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 11.68 | acidic |
| pKa2 | 12.82 | acidic |
| pKa3 | 4.2 | Basic |
| pKa4 | 1.68 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| SARS-CoV-2 | Virus | INHIBITOR | EC50 | 6.11 | SCIENTIFIC LITERATURE | ||||
| Ebola virus (EBOV) | Virus | INHIBITOR | EC50 | 7.06 | SCIENTIFIC LITERATURE |
External reference:
| ID | Source |
|---|---|
| 3QKI37EEHE | UNII |
| 10478 | INN_ID |
| 121304016 | PUBCHEM_CID |
| CHEBI:145994 | CHEBI |
| C000606551 | MESH_SUPPLEMENTAL_RECORD_UI |
| DB14761 | DRUGBANK_ID |
| CHEMBL4065616 | ChEMBL_ID |
| D11472 | KEGG_DRUG |
| 10715 | IUPHAR_LIGAND_ID |
Pharmaceutical products:
None