cepharanthine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
5375 481-49-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • cepharanthine
  • cepharanthin
The mechanism of action of cepharanthine is multifactorial. The drug exerts membrane effects (modulation of efflux pumps, membrane rigidification) as well as different intracellular and nuclear effects. Cepharanthine interferes with several metabolic axes, primarily with the AMP-activated protein kinase (AMPK) and NFkappaB signaling pathways. In particular, the anti-inflammatory effects of cepharanthine rely on AMPK activation and NFkappaB inhibition.
  • Molecular weight: 606.72
  • Formula: C37H38N2O6
  • CLOGP: 7.59
  • LIPINSKI: 2
  • HAC: 8
  • HDO: 0
  • TPSA: 61.86
  • ALOGS: -5.10
  • ROTB: 2

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Jan. 1, 1951 PMDA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D000700 Analgesics
MeSH PA D018712 Analgesics, Non-Narcotic
MeSH PA D000893 Anti-Inflammatory Agents
MeSH PA D000894 Anti-Inflammatory Agents, Non-Steroidal
MeSH PA D000970 Antineoplastic Agents
MeSH PA D000972 Antineoplastic Agents, Phytogenic
MeSH PA D018501 Antirheumatic Agents
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D020011 Protective Agents
MeSH PA D011837 Radiation-Protective Agents
MeSH PA D018689 Sensory System Agents

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Alopecia indication 56317004 DOID:987
Leukopenia indication 84828003 DOID:615
Aptyalism indication 87715008
Snake bite - wound indication 283840005
Coronavirus infection off-label use 186747009




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.38 Basic
pKa2 7.62 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
5'-AMP-activated protein kinase catalytic subunit alpha-1 Kinase INHIBITOR SCIENTIFIC LITERATURE SCIENTIFIC LITERATURE
Nuclear factor NF-kappa-B p105 subunit Cytosolic other INHIBITOR SCIENTIFIC LITERATURE SCIENTIFIC LITERATURE
Trypanothione reductase Enzyme Ki 5.12 CHEMBL

External reference:

IDSource
7592YJ0J6T UNII
C0055082 UMLSCUI
CHEBI:3546 CHEBI
CHEMBL449782 ChEMBL_ID
10206 PUBCHEM_CID
CHEMBL2074948 ChEMBL_ID
D01035 KEGG_DRUG
C006947 MESH_SUPPLEMENTAL_RECORD_UI

Pharmaceutical products:

None