cepharanthine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	5375	481-49-2

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: cepharanthine cepharanthin	The mechanism of action of cepharanthine is multifactorial. The drug exerts membrane effects (modulation of efflux pumps, membrane rigidification) as well as different intracellular and nuclear effects. Cepharanthine interferes with several metabolic axes, primarily with the AMP-activated protein kinase (AMPK) and NFkappaB signaling pathways. In particular, the anti-inflammatory effects of cepharanthine rely on AMPK activation and NFkappaB inhibition. Molecular weight: 606.72 Formula: C37H38N2O6 CLOGP: 7.59 LIPINSKI: 2 HAC: 8 HDO: 0 TPSA: 61.86 ALOGS: -5.10 ROTB: 2

Molecule

Description

Molfile Inchi Smiles

Synonyms:

cepharanthine
cepharanthin

The mechanism of action of cepharanthine is multifactorial. The drug exerts membrane effects (modulation of efflux pumps, membrane rigidification) as well as different intracellular and nuclear effects. Cepharanthine interferes with several metabolic axes, primarily with the AMP-activated protein kinase (AMPK) and NFkappaB signaling pathways. In particular, the anti-inflammatory effects of cepharanthine rely on AMPK activation and NFkappaB inhibition.

Molecular weight: 606.72
Formula: C37H38N2O6
CLOGP: 7.59
LIPINSKI: 2
HAC: 8
HDO: 0
TPSA: 61.86
ALOGS: -5.10
ROTB: 2

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
Jan. 1, 1951	PMDA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
MeSH PA	D000700	Analgesics
MeSH PA	D018712	Analgesics, Non-Narcotic
MeSH PA	D000893	Anti-Inflammatory Agents
MeSH PA	D000894	Anti-Inflammatory Agents, Non-Steroidal
MeSH PA	D000970	Antineoplastic Agents
MeSH PA	D000972	Antineoplastic Agents, Phytogenic
MeSH PA	D018501	Antirheumatic Agents
MeSH PA	D018373	Peripheral Nervous System Agents
MeSH PA	D020011	Protective Agents
MeSH PA	D011837	Radiation-Protective Agents
MeSH PA	D018689	Sensory System Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Alopecia	indication	56317004	DOID:987
Leukopenia	indication	84828003	DOID:615
Aptyalism	indication	87715008
Snake bite - wound	indication	283840005
Coronavirus infection	off-label use	186747009

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	8.38	Basic
pKa2	7.62	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Bioact source	MoA source
5'-AMP-activated protein kinase catalytic subunit alpha-1	Kinase	Q13131	AAPK1_HUMAN	INHIBITOR			SCIENTIFIC LITERATURE	SCIENTIFIC LITERATURE
Nuclear factor NF-kappa-B p105 subunit	Cytosolic other	P19838	NFKB1_HUMAN	INHIBITOR			SCIENTIFIC LITERATURE	SCIENTIFIC LITERATURE
Trypanothione reductase	Enzyme		TYTR_TRYCR		Ki	5.12	CHEMBL

External reference:

ID	Source
7592YJ0J6T	UNII
C0055082	UMLSCUI
CHEBI:3546	CHEBI
CHEMBL449782	ChEMBL_ID
10206	PUBCHEM_CID
DB16824	DRUGBANK_ID
CHEMBL2074948	ChEMBL_ID
D01035	KEGG_DRUG
C006947	MESH_SUPPLEMENTAL_RECORD_UI

Pharmaceutical products:

None