| Stem definition | Drug id | CAS RN |
|---|---|---|
| 5368 | None |
| Molecule | Description |
|---|---|
|
Synonyms:
|
Botulinum toxin type A (Clostridium botulinum neurotoxin) blocks peripheral acetylcholine release at presynaptic cholinergic nerve terminals by cleaving SNAP-25, a protein integral to the successful docking and release of acetylcholine from vesicles situated within the nerve endings, thereby leading to denervation of the muscle and a flaccid paralysis.
|
None
None
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Sept. 27, 2019 | EMA | Evolus Pharma Limited | |
| Dec. 20, 2019 | PMDA | GlaxoSmithKline K.K. |
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Drug ineffective | 21939.63 | 21.11 | 13742 | 61280 | 805591 | 49724511 |
| Product preparation error | 9026.64 | 21.11 | 1918 | 73104 | 2454 | 50527648 |
| Therapeutic response decreased | 7344.17 | 21.11 | 2718 | 72304 | 44513 | 50485589 |
| Eyelid ptosis | 5275.01 | 21.11 | 1323 | 73699 | 4864 | 50525238 |
| Off label use | 4740.12 | 21.11 | 4545 | 70477 | 469881 | 50060221 |
| Multiple use of single-use product | 4405.72 | 21.11 | 835 | 74187 | 232 | 50529870 |
| Wrong technique in product usage process | 4318.52 | 21.11 | 1947 | 73075 | 53563 | 50476539 |
| Injection site pain | 2478.10 | 21.11 | 1712 | 73310 | 109312 | 50420790 |
| Facial paresis | 1407.90 | 21.11 | 405 | 74617 | 2747 | 50527355 |
| Brow ptosis | 1062.12 | 21.11 | 203 | 74819 | 67 | 50530035 |
| Product preparation issue | 1059.60 | 21.11 | 236 | 74786 | 425 | 50529677 |
| Poor quality product administered | 1025.50 | 21.11 | 309 | 74713 | 2510 | 50527592 |
| Injection site swelling | 799.22 | 21.11 | 588 | 74434 | 41185 | 50488917 |
| Drug ineffective for unapproved indication | 744.25 | 21.11 | 437 | 74585 | 20844 | 50509258 |
| Dysphagia | 713.06 | 21.11 | 717 | 74305 | 76801 | 50453301 |
| Product storage error | 672.70 | 21.11 | 339 | 74683 | 11885 | 50518217 |
| Swelling face | 649.48 | 21.11 | 573 | 74449 | 52022 | 50478080 |
| Eye swelling | 612.14 | 21.11 | 378 | 74644 | 19766 | 50510336 |
| Muscular weakness | 563.68 | 21.11 | 699 | 74323 | 94314 | 50435788 |
| Eyelid oedema | 490.19 | 21.11 | 252 | 74770 | 9214 | 50520888 |
| Botulism | 461.29 | 21.11 | 94 | 74928 | 79 | 50530023 |
| Vision blurred | 407.08 | 21.11 | 541 | 74481 | 78106 | 50451996 |
| Facial paralysis | 349.56 | 21.11 | 224 | 74798 | 12491 | 50517611 |
| Therapeutic response shortened | 343.44 | 21.11 | 183 | 74839 | 7206 | 50522896 |
| Facial asymmetry | 326.22 | 21.11 | 92 | 74930 | 574 | 50529528 |
| Diarrhoea | 321.48 | 21.11 | 243 | 74779 | 588233 | 49941869 |
| Neck pain | 306.67 | 21.11 | 400 | 74622 | 56667 | 50473435 |
| Anaemia | 299.48 | 21.11 | 19 | 75003 | 252437 | 50277665 |
| Diplopia | 293.41 | 21.11 | 237 | 74785 | 19023 | 50511079 |
| Arthralgia | 280.55 | 21.11 | 151 | 74871 | 438551 | 50091551 |
| Neuromuscular toxicity | 277.32 | 21.11 | 60 | 74962 | 87 | 50530015 |
| Acute kidney injury | 277.06 | 21.11 | 15 | 75007 | 228043 | 50302059 |
| Headache | 267.07 | 21.11 | 1463 | 73559 | 505072 | 50025030 |
| Pneumonia | 249.58 | 21.11 | 125 | 74897 | 378276 | 50151826 |
| Influenza like illness | 248.90 | 21.11 | 363 | 74659 | 57096 | 50473006 |
| Skin tightness | 244.72 | 21.11 | 117 | 74905 | 3646 | 50526456 |
| Joint swelling | 236.05 | 21.11 | 40 | 74982 | 245246 | 50284856 |
| Migraine | 227.91 | 21.11 | 404 | 74618 | 74876 | 50455226 |
| Toxicity to various agents | 217.40 | 21.11 | 29 | 74993 | 212470 | 50317632 |
| Incorrect route of product administration | 215.57 | 21.11 | 196 | 74826 | 18470 | 50511632 |
| Injection site rash | 215.08 | 21.11 | 184 | 74838 | 15993 | 50514109 |
| Facial pain | 213.97 | 21.11 | 136 | 74886 | 7473 | 50522629 |
| Periorbital swelling | 198.26 | 21.11 | 82 | 74940 | 1795 | 50528307 |
| Rheumatoid arthritis | 194.89 | 21.11 | 33 | 74989 | 202517 | 50327585 |
| Contraindicated product administered | 193.50 | 21.11 | 6 | 75016 | 148952 | 50381150 |
| Neutropenia | 192.07 | 21.11 | 6 | 75016 | 147959 | 50382143 |
| Drug interaction | 186.68 | 21.11 | 35 | 74987 | 199586 | 50330516 |
| Eyelid sensory disorder | 186.05 | 21.11 | 36 | 74986 | 15 | 50530087 |
| Abdominal discomfort | 184.59 | 21.11 | 57 | 74965 | 231584 | 50298518 |
| Maternal exposure during pregnancy | 183.60 | 21.11 | 14 | 75008 | 159764 | 50370338 |
| Infusion related reaction | 181.10 | 21.11 | 20 | 75002 | 169537 | 50360565 |
| Product administered at inappropriate site | 180.61 | 21.11 | 83 | 74939 | 2360 | 50527742 |
| Hypotension | 180.49 | 21.11 | 62 | 74960 | 235407 | 50294695 |
| Lagophthalmos | 178.13 | 21.11 | 48 | 74974 | 246 | 50529856 |
| Injection site erythema | 174.77 | 21.11 | 360 | 74662 | 74576 | 50455526 |
| Systemic lupus erythematosus | 174.66 | 21.11 | 8 | 75014 | 140614 | 50389488 |
| Thrombocytopenia | 174.07 | 21.11 | 3 | 75019 | 127670 | 50402432 |
| Arthropathy | 170.23 | 21.11 | 18 | 75004 | 157888 | 50372214 |
| Fall | 168.99 | 21.11 | 149 | 74873 | 334783 | 50195319 |
| Completed suicide | 168.86 | 21.11 | 6 | 75016 | 131883 | 50398219 |
| Injection site mass | 168.17 | 21.11 | 158 | 74864 | 15522 | 50514580 |
| Hepatic enzyme increased | 163.78 | 21.11 | 10 | 75012 | 137370 | 50392732 |
| Product quality issue | 155.96 | 21.11 | 210 | 74812 | 30648 | 50499454 |
| Drug hypersensitivity | 154.91 | 21.11 | 90 | 74932 | 250920 | 50279182 |
| Death | 150.99 | 21.11 | 156 | 74866 | 325223 | 50204879 |
| Hypoaesthesia | 149.12 | 21.11 | 471 | 74551 | 126786 | 50403316 |
| Product distribution issue | 147.70 | 21.11 | 51 | 74971 | 663 | 50529439 |
| Peripheral swelling | 146.46 | 21.11 | 61 | 74961 | 205875 | 50324227 |
| Sepsis | 146.26 | 21.11 | 14 | 75008 | 132911 | 50397191 |
| General physical health deterioration | 141.93 | 21.11 | 21 | 75001 | 142413 | 50387689 |
| Blepharospasm | 139.76 | 21.11 | 74 | 74948 | 2874 | 50527228 |
| Glossodynia | 139.00 | 21.11 | 8 | 75014 | 115561 | 50414541 |
| Muscle twitching | 138.40 | 21.11 | 141 | 74881 | 15290 | 50514812 |
| Inappropriate schedule of product administration | 135.59 | 21.11 | 317 | 74705 | 71514 | 50458588 |
| Oedema peripheral | 131.03 | 21.11 | 36 | 74986 | 157925 | 50372177 |
| Infection | 129.96 | 21.11 | 47 | 74975 | 172907 | 50357195 |
| Swelling of eyelid | 124.51 | 21.11 | 59 | 74963 | 1801 | 50528301 |
| Condition aggravated | 124.08 | 21.11 | 155 | 74867 | 296903 | 50233199 |
| Renal failure | 123.44 | 21.11 | 9 | 75013 | 106624 | 50423478 |
| Injection site nodule | 122.89 | 21.11 | 71 | 74951 | 3277 | 50526825 |
| Wound | 119.46 | 21.11 | 10 | 75012 | 105784 | 50424318 |
| Incorrect dose administered | 118.06 | 21.11 | 237 | 74785 | 48177 | 50481925 |
| Abdominal pain | 117.93 | 21.11 | 106 | 74916 | 236122 | 50293980 |
| Haemoglobin decreased | 117.39 | 21.11 | 23 | 74999 | 127193 | 50402909 |
| Vomiting | 116.79 | 21.11 | 326 | 74696 | 460432 | 50069670 |
| Head discomfort | 116.18 | 21.11 | 110 | 74912 | 10909 | 50519193 |
| Periorbital oedema | 115.21 | 21.11 | 79 | 74943 | 4933 | 50525169 |
| Pyrexia | 115.20 | 21.11 | 245 | 74777 | 379958 | 50150144 |
| Nasopharyngitis | 112.27 | 21.11 | 74 | 74948 | 192853 | 50337249 |
| Muscle tightness | 109.10 | 21.11 | 103 | 74919 | 10177 | 50519925 |
| Hyponatraemia | 108.78 | 21.11 | 9 | 75013 | 96130 | 50433972 |
| Disease progression | 108.40 | 21.11 | 9 | 75013 | 95857 | 50434245 |
| Platelet count decreased | 104.72 | 21.11 | 13 | 75009 | 100713 | 50429389 |
| Dysphonia | 104.07 | 21.11 | 198 | 74824 | 38694 | 50491408 |
| Drug intolerance | 103.85 | 21.11 | 103 | 74919 | 219001 | 50311101 |
| Asthenopia | 102.88 | 21.11 | 53 | 74969 | 1944 | 50528158 |
| Injection site urticaria | 101.23 | 21.11 | 107 | 74915 | 12110 | 50517992 |
| Confusional state | 100.71 | 21.11 | 77 | 74945 | 185851 | 50344251 |
| Dry eye | 99.30 | 21.11 | 174 | 74848 | 31921 | 50498181 |
| Pain in extremity | 98.39 | 21.11 | 158 | 74864 | 272707 | 50257395 |
| Renal impairment | 98.38 | 21.11 | 3 | 75019 | 75658 | 50454444 |
| Eye pain | 98.28 | 21.11 | 162 | 74860 | 28287 | 50501815 |
| Hypertension | 98.14 | 21.11 | 101 | 74921 | 211102 | 50319000 |
| Weight increased | 97.88 | 21.11 | 93 | 74929 | 201798 | 50328304 |
| Hypokalaemia | 97.48 | 21.11 | 9 | 75013 | 87983 | 50442119 |
| Lacrimation increased | 97.30 | 21.11 | 123 | 74899 | 16869 | 50513233 |
| Pleural effusion | 96.83 | 21.11 | 6 | 75016 | 81448 | 50448654 |
| Fatigue | 95.91 | 21.11 | 636 | 74386 | 706965 | 49823137 |
| Injection site bruising | 95.69 | 21.11 | 185 | 74837 | 36583 | 50493519 |
| Gastrointestinal haemorrhage | 95.00 | 21.11 | 3 | 75019 | 73318 | 50456784 |
| Atrial fibrillation | 94.69 | 21.11 | 18 | 75004 | 101727 | 50428375 |
| Overdose | 94.60 | 21.11 | 344 | 74678 | 99383 | 50430719 |
| Stomatitis | 94.17 | 21.11 | 18 | 75004 | 101326 | 50428776 |
| Injection site paraesthesia | 94.00 | 21.11 | 33 | 74989 | 452 | 50529650 |
| Blood creatinine increased | 92.40 | 21.11 | 5 | 75017 | 76155 | 50453947 |
| Alopecia | 89.17 | 21.11 | 141 | 74881 | 244906 | 50285196 |
| Hypoaesthesia oral | 88.96 | 21.11 | 94 | 74928 | 10634 | 50519468 |
| Cough | 87.62 | 21.11 | 139 | 74883 | 241125 | 50288977 |
| Cardiac failure congestive | 87.44 | 21.11 | 11 | 75011 | 84371 | 50445731 |
| Lower respiratory tract infection | 86.17 | 21.11 | 18 | 75004 | 95183 | 50434919 |
| White blood cell count decreased | 85.49 | 21.11 | 33 | 74989 | 116689 | 50413413 |
| Decreased appetite | 84.68 | 21.11 | 104 | 74918 | 200819 | 50329283 |
| Treatment failure | 83.89 | 21.11 | 50 | 74972 | 137587 | 50392515 |
| Aspartate aminotransferase increased | 83.73 | 21.11 | 9 | 75013 | 77989 | 50452113 |
| Alanine aminotransferase increased | 83.58 | 21.11 | 15 | 75007 | 88344 | 50441758 |
| Pulmonary embolism | 82.78 | 21.11 | 24 | 74998 | 101680 | 50428422 |
| Dehydration | 82.71 | 21.11 | 63 | 74959 | 152386 | 50377716 |
| Cardiac failure | 81.05 | 21.11 | 9 | 75013 | 76031 | 50454071 |
| Impaired healing | 80.44 | 21.11 | 6 | 75016 | 69780 | 50460322 |
| Product dose omission issue | 79.76 | 21.11 | 93 | 74929 | 183745 | 50346357 |
| Cardiac arrest | 79.56 | 21.11 | 14 | 75008 | 83637 | 50446465 |
| Myocardial infarction | 78.21 | 21.11 | 18 | 75004 | 89009 | 50441093 |
| Pain | 76.95 | 21.11 | 523 | 74499 | 578380 | 49951722 |
| Gastrointestinal disorder | 75.58 | 21.11 | 23 | 74999 | 94433 | 50435669 |
| Neuropathy peripheral | 74.86 | 21.11 | 25 | 74997 | 96732 | 50433370 |
| Facial spasm | 74.61 | 21.11 | 30 | 74992 | 609 | 50529493 |
| Bronchitis | 73.74 | 21.11 | 31 | 74991 | 104128 | 50425974 |
| Intentional overdose | 73.12 | 21.11 | 5 | 75017 | 62499 | 50467603 |
| Drug abuse | 72.37 | 21.11 | 4 | 75018 | 59842 | 50470260 |
| Back pain | 71.46 | 21.11 | 136 | 74886 | 219894 | 50310208 |
| Speech disorder | 70.47 | 21.11 | 160 | 74862 | 35388 | 50494714 |
| Burning sensation | 69.34 | 21.11 | 185 | 74837 | 45261 | 50484841 |
| Product use issue | 68.80 | 21.11 | 72 | 74950 | 149403 | 50380699 |
| Paraesthesia | 66.64 | 21.11 | 353 | 74669 | 119890 | 50410212 |
| Injection site hypoaesthesia | 66.49 | 21.11 | 24 | 74998 | 358 | 50529744 |
| Deep vein thrombosis | 66.04 | 21.11 | 14 | 75008 | 73290 | 50456812 |
| Leukopenia | 64.87 | 21.11 | 11 | 75011 | 67517 | 50462585 |
| Urinary tract infection | 64.72 | 21.11 | 148 | 74874 | 223872 | 50306230 |
| Product reconstitution quality issue | 63.58 | 21.11 | 15 | 75007 | 39 | 50530063 |
| Exposure during pregnancy | 63.12 | 21.11 | 52 | 74970 | 120963 | 50409139 |
| Product packaging issue | 62.67 | 21.11 | 30 | 74992 | 937 | 50529165 |
| Coma | 62.51 | 21.11 | 6 | 75016 | 56873 | 50473229 |
| Patient dissatisfaction with treatment | 62.26 | 21.11 | 15 | 75007 | 44 | 50530058 |
| Sinusitis | 62.12 | 21.11 | 98 | 74924 | 170460 | 50359642 |
| Multiple organ dysfunction syndrome | 62.02 | 21.11 | 3 | 75019 | 50334 | 50479768 |
| Lid sulcus deepened | 61.63 | 21.11 | 16 | 75006 | 69 | 50530033 |
| Respiratory failure | 61.61 | 21.11 | 29 | 74993 | 91152 | 50438950 |
| Facial discomfort | 61.55 | 21.11 | 14 | 75008 | 29 | 50530073 |
| Blood glucose increased | 61.50 | 21.11 | 15 | 75007 | 71309 | 50458793 |
| Nausea | 60.80 | 21.11 | 712 | 74310 | 704686 | 49825416 |
| Hypoxia | 60.06 | 21.11 | 4 | 75018 | 51119 | 50478983 |
| Injection site oedema | 59.05 | 21.11 | 30 | 74992 | 1068 | 50529034 |
| Product temperature excursion issue | 58.74 | 21.11 | 16 | 75006 | 86 | 50530016 |
| Bradycardia | 58.67 | 21.11 | 12 | 75010 | 64414 | 50465688 |
| Neovascularisation | 58.37 | 21.11 | 29 | 74993 | 984 | 50529118 |
| Electrocardiogram QT prolonged | 58.29 | 21.11 | 5 | 75017 | 51881 | 50478221 |
| Hypoglycaemia | 57.97 | 21.11 | 6 | 75016 | 53575 | 50476527 |
| Septic shock | 57.92 | 21.11 | 8 | 75014 | 57167 | 50472935 |
| Mastication disorder | 56.70 | 21.11 | 35 | 74987 | 1825 | 50528277 |
| Paralysis | 56.53 | 21.11 | 67 | 74955 | 8597 | 50521505 |
| Ophthalmoplegia | 56.17 | 21.11 | 31 | 74991 | 1309 | 50528793 |
| Photophobia | 55.81 | 21.11 | 88 | 74934 | 14799 | 50515303 |
| Intentional product misuse | 55.59 | 21.11 | 174 | 74848 | 46560 | 50483542 |
| Suicide attempt | 55.44 | 21.11 | 6 | 75016 | 51726 | 50478376 |
| Blister | 54.95 | 21.11 | 29 | 74993 | 85389 | 50444713 |
| Drug effect less than expected | 54.56 | 21.11 | 22 | 75000 | 450 | 50529652 |
| Ocular discomfort | 54.53 | 21.11 | 43 | 74979 | 3330 | 50526772 |
| Pulmonary oedema | 54.21 | 21.11 | 5 | 75017 | 48933 | 50481169 |
| Liver function test abnormal | 53.50 | 21.11 | 3 | 75019 | 44336 | 50485766 |
| Constipation | 53.36 | 21.11 | 123 | 74899 | 185585 | 50344517 |
| Abnormal sensation in eye | 53.04 | 21.11 | 32 | 74990 | 1601 | 50528501 |
| Throat tightness | 51.93 | 21.11 | 103 | 74919 | 20744 | 50509358 |
| International normalised ratio increased | 51.82 | 21.11 | 3 | 75019 | 43149 | 50486953 |
| Eyelid pain | 51.24 | 21.11 | 18 | 75004 | 247 | 50529855 |
| Chronic obstructive pulmonary disease | 50.68 | 21.11 | 9 | 75013 | 53426 | 50476676 |
| Neutrophil count decreased | 50.19 | 21.11 | 5 | 75017 | 46021 | 50484081 |
| Oxygen saturation decreased | 49.94 | 21.11 | 23 | 74999 | 73225 | 50456877 |
| Central nervous system function test abnormal | 49.64 | 21.11 | 9 | 75013 | 0 | 50530102 |
| Injection site haemorrhage | 49.06 | 21.11 | 102 | 74920 | 21244 | 50508858 |
| Blood cholesterol increased | 48.81 | 21.11 | 11 | 75011 | 55204 | 50474898 |
| Hypoaesthesia eye | 48.67 | 21.11 | 13 | 75009 | 64 | 50530038 |
| C-reactive protein increased | 48.31 | 21.11 | 19 | 75003 | 66455 | 50463647 |
| Injection site discomfort | 48.11 | 21.11 | 42 | 74980 | 3748 | 50526354 |
| Eye discharge | 48.11 | 21.11 | 48 | 74974 | 5075 | 50525027 |
| Suspected product quality issue | 47.72 | 21.11 | 16 | 75006 | 189 | 50529913 |
| Thrombosis | 47.63 | 21.11 | 12 | 75010 | 55821 | 50474281 |
| Mucosal inflammation | 47.57 | 21.11 | 3 | 75019 | 40139 | 50489963 |
| Cardio-respiratory arrest | 47.12 | 21.11 | 11 | 75011 | 53881 | 50476221 |
| Irritable bowel syndrome | 45.98 | 21.11 | 10 | 75012 | 51431 | 50478671 |
| Lip swelling | 45.36 | 21.11 | 108 | 74914 | 24628 | 50505474 |
| Strabismus | 44.81 | 21.11 | 30 | 74992 | 1800 | 50528302 |
| Osteoporosis | 43.79 | 21.11 | 7 | 75015 | 44872 | 50485230 |
| Accidental exposure to product | 43.73 | 21.11 | 102 | 74920 | 22955 | 50507147 |
| Abdominal distension | 43.67 | 21.11 | 27 | 74995 | 72876 | 50457226 |
| Urticaria | 43.55 | 21.11 | 335 | 74687 | 129226 | 50400876 |
| Eye pruritus | 42.78 | 21.11 | 71 | 74951 | 12463 | 50517639 |
| Tension headache | 42.41 | 21.11 | 34 | 74988 | 2697 | 50527405 |
| Manufacturing product shipping issue | 42.39 | 21.11 | 12 | 75010 | 76 | 50530026 |
| Erythema of eyelid | 42.38 | 21.11 | 29 | 74993 | 1804 | 50528298 |
| Eye irritation | 41.87 | 21.11 | 84 | 74938 | 17056 | 50513046 |
| Fluid retention | 41.11 | 21.11 | 12 | 75010 | 50637 | 50479465 |
| Eyelid disorder | 40.98 | 21.11 | 25 | 74997 | 1276 | 50528826 |
| Depressed level of consciousness | 40.92 | 21.11 | 13 | 75009 | 51940 | 50478162 |
| Arthritis | 40.76 | 21.11 | 41 | 74981 | 86680 | 50443422 |
| Psoriatic arthropathy | 40.33 | 21.11 | 10 | 75012 | 47022 | 50483080 |
| Lung disorder | 39.45 | 21.11 | 9 | 75013 | 44790 | 50485312 |
| Haematochezia | 39.42 | 21.11 | 6 | 75016 | 39876 | 50490226 |
| Agitation | 39.22 | 21.11 | 15 | 75007 | 53369 | 50476733 |
| Diabetes mellitus | 39.10 | 21.11 | 12 | 75010 | 49021 | 50481081 |
| Muscle contractions involuntary | 38.84 | 21.11 | 28 | 74994 | 1894 | 50528208 |
| Skin indentation | 38.84 | 21.11 | 9 | 75013 | 21 | 50530081 |
| Ocular hyperaemia | 38.73 | 21.11 | 90 | 74932 | 20202 | 50509900 |
| Skin wrinkling | 38.59 | 21.11 | 21 | 75001 | 862 | 50529240 |
| Femur fracture | 38.52 | 21.11 | 5 | 75017 | 37459 | 50492643 |
| Injection site indentation | 38.44 | 21.11 | 13 | 75009 | 158 | 50529944 |
| Dyspnoea exertional | 38.30 | 21.11 | 14 | 75008 | 51219 | 50478883 |
| Muscle atrophy | 37.75 | 21.11 | 46 | 74976 | 6075 | 50524027 |
| Osteoarthritis | 37.63 | 21.11 | 28 | 74994 | 68578 | 50461524 |
| Colitis | 37.62 | 21.11 | 6 | 75016 | 38523 | 50491579 |
| Blood pressure increased | 37.56 | 21.11 | 89 | 74933 | 133043 | 50397059 |
| Ill-defined disorder | 37.51 | 21.11 | 17 | 75005 | 54637 | 50475465 |
| Delirium | 37.17 | 21.11 | 6 | 75016 | 38186 | 50491916 |
| Prescribed overdose | 36.20 | 21.11 | 72 | 74950 | 14528 | 50515574 |
| White blood cell count increased | 36.18 | 21.11 | 9 | 75013 | 42231 | 50487871 |
| Madarosis | 35.82 | 21.11 | 30 | 74992 | 2530 | 50527572 |
| Injection site pruritus | 35.44 | 21.11 | 136 | 74886 | 40275 | 50489827 |
| Hepatitis | 35.41 | 21.11 | 3 | 75019 | 31450 | 50498652 |
| Cataract | 35.24 | 21.11 | 13 | 75009 | 47287 | 50482815 |
| Epistaxis | 35.21 | 21.11 | 26 | 74996 | 63928 | 50466174 |
| Pancreatitis | 34.76 | 21.11 | 10 | 75012 | 42604 | 50487498 |
| Post-traumatic neck syndrome | 34.48 | 21.11 | 26 | 74996 | 1884 | 50528218 |
| Chest pain | 34.47 | 21.11 | 140 | 74882 | 176742 | 50353360 |
| Vertigo | 34.24 | 21.11 | 160 | 74862 | 51672 | 50478430 |
| Knee arthroplasty | 34.07 | 21.11 | 6 | 75016 | 35840 | 50494262 |
| Rhabdomyolysis | 34.05 | 21.11 | 8 | 75014 | 39019 | 50491083 |
| Hip arthroplasty | 33.99 | 21.11 | 3 | 75019 | 30426 | 50499676 |
| Hepatic failure | 33.94 | 21.11 | 4 | 75018 | 32279 | 50497823 |
| Liver disorder | 33.74 | 21.11 | 7 | 75015 | 37215 | 50492887 |
| Red blood cell count decreased | 33.65 | 21.11 | 5 | 75017 | 33830 | 50496272 |
| Blood bilirubin increased | 33.61 | 21.11 | 4 | 75018 | 32034 | 50498068 |
| Muscle injury | 33.60 | 21.11 | 7 | 75015 | 37104 | 50492998 |
| Nerve injury | 33.60 | 21.11 | 51 | 74971 | 8299 | 50521803 |
| Blood pressure systolic increased | 33.55 | 21.11 | 6 | 75016 | 35443 | 50494659 |
| Hospitalisation | 33.22 | 21.11 | 31 | 74991 | 67906 | 50462196 |
| Mobility decreased | 32.99 | 21.11 | 42 | 74980 | 79906 | 50450196 |
| Choking | 32.92 | 21.11 | 51 | 74971 | 8447 | 50521655 |
| Gamma-glutamyltransferase increased | 32.88 | 21.11 | 3 | 75019 | 29620 | 50500482 |
| Pneumonitis | 32.72 | 21.11 | 3 | 75019 | 29507 | 50500595 |
| Mental status changes | 32.52 | 21.11 | 7 | 75015 | 36265 | 50493837 |
| Lip disorder | 32.35 | 21.11 | 21 | 75001 | 1196 | 50528906 |
| Pregnancy | 32.33 | 21.11 | 107 | 74915 | 29470 | 50500632 |
| Blood alkaline phosphatase increased | 32.13 | 21.11 | 8 | 75014 | 37518 | 50492584 |
| Libido increased | 31.94 | 21.11 | 21 | 75001 | 1222 | 50528880 |
| Wheezing | 31.92 | 21.11 | 27 | 74995 | 62020 | 50468082 |
| Rectal haemorrhage | 31.54 | 21.11 | 9 | 75013 | 38549 | 50491553 |
| Cutis laxa | 31.38 | 21.11 | 11 | 75011 | 150 | 50529952 |
| Haematocrit decreased | 30.85 | 21.11 | 7 | 75015 | 34969 | 50495133 |
| Application site acne | 30.67 | 21.11 | 6 | 75016 | 3 | 50530099 |
| Blood pressure decreased | 30.42 | 21.11 | 23 | 74999 | 55886 | 50474216 |
| Haemorrhage | 30.37 | 21.11 | 21 | 75001 | 53420 | 50476682 |
| Injection site anaesthesia | 30.36 | 21.11 | 8 | 75014 | 37 | 50530065 |
| Injection site inflammation | 30.04 | 21.11 | 30 | 74992 | 3175 | 50526927 |
| Oedema | 29.87 | 21.11 | 36 | 74986 | 70145 | 50459957 |
| Injury | 29.47 | 21.11 | 18 | 75004 | 48907 | 50481195 |
| Somnolence | 29.36 | 21.11 | 124 | 74898 | 154861 | 50375241 |
| Encephalopathy | 29.23 | 21.11 | 7 | 75015 | 33704 | 50496398 |
| Skin disorder | 29.05 | 21.11 | 90 | 74932 | 23940 | 50506162 |
| Hypocalcaemia | 29.01 | 21.11 | 3 | 75019 | 26813 | 50503289 |
| Rash maculo-papular | 28.77 | 21.11 | 3 | 75019 | 26638 | 50503464 |
| Treatment noncompliance | 28.76 | 21.11 | 5 | 75017 | 30145 | 50499957 |
| Psoriasis | 28.73 | 21.11 | 36 | 74986 | 68964 | 50461138 |
| Soft tissue injury | 28.58 | 21.11 | 21 | 75001 | 1463 | 50528639 |
| Jaundice | 28.48 | 21.11 | 3 | 75019 | 26426 | 50503676 |
| Vestibular migraine | 28.18 | 21.11 | 11 | 75011 | 206 | 50529896 |
| Muscle spasms | 28.00 | 21.11 | 297 | 74725 | 125256 | 50404846 |
| Injection site pallor | 27.95 | 21.11 | 8 | 75014 | 53 | 50530049 |
| Haematemesis | 27.79 | 21.11 | 4 | 75018 | 27721 | 50502381 |
| Dry mouth | 27.79 | 21.11 | 160 | 74862 | 56018 | 50474084 |
| Injection site alopecia | 27.58 | 21.11 | 5 | 75017 | 0 | 50530102 |
| Intranasal hypoaesthesia | 27.58 | 21.11 | 5 | 75017 | 0 | 50530102 |
| Skin ulcer | 27.52 | 21.11 | 9 | 75013 | 35309 | 50494793 |
| Pericardial effusion | 27.33 | 21.11 | 3 | 75019 | 25586 | 50504516 |
| Haemoptysis | 27.31 | 21.11 | 3 | 75019 | 25570 | 50504532 |
| Hostility | 27.28 | 21.11 | 22 | 75000 | 1760 | 50528342 |
| Erythema | 27.10 | 21.11 | 334 | 74688 | 146080 | 50384022 |
| Eye contusion | 27.01 | 21.11 | 21 | 75001 | 1593 | 50528509 |
| Drooling | 26.90 | 21.11 | 29 | 74993 | 3355 | 50526747 |
| Malaise | 26.72 | 21.11 | 344 | 74678 | 335188 | 50194914 |
| Diverticulitis | 26.67 | 21.11 | 8 | 75014 | 33174 | 50496928 |
| Sensation of foreign body | 26.61 | 21.11 | 31 | 74991 | 3905 | 50526197 |
| Eyelid thickening | 26.43 | 21.11 | 8 | 75014 | 66 | 50530036 |
| Cellulitis | 26.40 | 21.11 | 40 | 74982 | 70758 | 50459344 |
| Diaphragmatic rupture | 26.29 | 21.11 | 11 | 75011 | 248 | 50529854 |
| Serotonin syndrome | 26.14 | 21.11 | 3 | 75019 | 24710 | 50505392 |
| Intestinal obstruction | 26 | 21.11 | 4 | 75018 | 26379 | 50503723 |
| Gastric disorder | 25.89 | 21.11 | 6 | 75016 | 29542 | 50500560 |
| Injection site haematoma | 25.79 | 21.11 | 38 | 74984 | 6022 | 50524080 |
| Flatulence | 25.77 | 21.11 | 6 | 75016 | 29452 | 50500650 |
| Angina pectoris | 25.74 | 21.11 | 4 | 75018 | 26184 | 50503918 |
| Torticollis | 25.66 | 21.11 | 21 | 75001 | 1715 | 50528387 |
| Rash | 25.51 | 21.11 | 476 | 74546 | 436995 | 50093107 |
| Product supply issue | 25.45 | 21.11 | 18 | 75004 | 1181 | 50528921 |
| Blepharochalasis | 25.23 | 21.11 | 5 | 75017 | 3 | 50530099 |
| Dermatochalasis | 25.23 | 21.11 | 5 | 75017 | 3 | 50530099 |
| Injection site scab | 25.21 | 21.11 | 12 | 75010 | 370 | 50529732 |
| Abdominal pain upper | 25.18 | 21.11 | 136 | 74886 | 159173 | 50370929 |
| Paradoxical drug reaction | 25.12 | 21.11 | 29 | 74993 | 3618 | 50526484 |
| Pancreatitis acute | 24.91 | 21.11 | 3 | 75019 | 23809 | 50506293 |
| Localised infection | 24.81 | 21.11 | 4 | 75018 | 25481 | 50504621 |
| Upper respiratory tract infection | 24.79 | 21.11 | 37 | 74985 | 65861 | 50464241 |
| Drug specific antibody | 24.74 | 21.11 | 21 | 75001 | 1804 | 50528298 |
| Vascular malformation | 24.63 | 21.11 | 11 | 75011 | 292 | 50529810 |
| Cerebrovascular accident | 24.60 | 21.11 | 66 | 74956 | 94614 | 50435488 |
| Eyelids pruritus | 24.39 | 21.11 | 15 | 75007 | 777 | 50529325 |
| Full blood count abnormal | 24.34 | 21.11 | 3 | 75019 | 23385 | 50506717 |
| Product quality control issue | 24.33 | 21.11 | 6 | 75016 | 20 | 50530082 |
| Mouth ulceration | 23.94 | 21.11 | 6 | 75016 | 28018 | 50502084 |
| Red blood cell sedimentation rate increased | 23.81 | 21.11 | 7 | 75015 | 29409 | 50500693 |
| Visual impairment | 23.74 | 21.11 | 178 | 74844 | 68097 | 50462005 |
| Dysarthria | 23.64 | 21.11 | 114 | 74908 | 37289 | 50492813 |
| Eyelid function disorder | 23.60 | 21.11 | 10 | 75012 | 233 | 50529869 |
| Hepatic steatosis | 23.35 | 21.11 | 4 | 75018 | 24380 | 50505722 |
| Sternal fracture | 23.06 | 21.11 | 21 | 75001 | 1981 | 50528121 |
| Gastritis | 23.04 | 21.11 | 10 | 75012 | 32973 | 50497129 |
| Application site papules | 22.99 | 21.11 | 7 | 75015 | 59 | 50530043 |
| Urinary retention | 22.85 | 21.11 | 88 | 74934 | 26102 | 50504000 |
| Cholelithiasis | 22.83 | 21.11 | 14 | 75008 | 37959 | 50492143 |
| Dyspnoea | 22.82 | 21.11 | 628 | 74394 | 546980 | 49983122 |
| Tachycardia | 22.69 | 21.11 | 74 | 74948 | 99689 | 50430413 |
| Injection site granuloma | 22.07 | 21.11 | 6 | 75016 | 32 | 50530070 |
| Injection site vesicles | 21.90 | 21.11 | 23 | 74999 | 2582 | 50527520 |
| Acute myocardial infarction | 21.88 | 21.11 | 8 | 75014 | 29265 | 50500837 |
| Feeling abnormal | 21.82 | 21.11 | 283 | 74739 | 125209 | 50404893 |
| Injection site discolouration | 21.81 | 21.11 | 38 | 74984 | 6936 | 50523166 |
| Blood potassium decreased | 21.69 | 21.11 | 14 | 75008 | 36931 | 50493171 |
| Paranasal cyst | 21.64 | 21.11 | 10 | 75012 | 288 | 50529814 |
| Gastric ulcer | 21.53 | 21.11 | 3 | 75019 | 21302 | 50508800 |
| Muscle hypertrophy | 21.49 | 21.11 | 7 | 75015 | 75 | 50530027 |
| Weight decreased | 21.44 | 21.11 | 217 | 74805 | 221028 | 50309074 |
| Productive cough | 21.41 | 21.11 | 28 | 74994 | 52666 | 50477436 |
| Pulmonary fibrosis | 21.33 | 21.11 | 5 | 75017 | 24432 | 50505670 |
| Blood sodium decreased | 21.32 | 21.11 | 3 | 75019 | 21144 | 50508958 |
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Drug ineffective | 2288.31 | 25.67 | 1416 | 8368 | 361754 | 29202989 |
| Off label use | 922.44 | 25.67 | 767 | 9017 | 300033 | 29264710 |
| Product preparation error | 864.60 | 25.67 | 180 | 9604 | 1482 | 29563261 |
| Therapeutic response decreased | 640.50 | 25.67 | 257 | 9527 | 24454 | 29540289 |
| Multiple use of single-use product | 475.40 | 25.67 | 79 | 9705 | 136 | 29564607 |
| Wrong technique in product usage process | 388.79 | 25.67 | 195 | 9589 | 31233 | 29533510 |
| Eyelid ptosis | 383.65 | 25.67 | 118 | 9666 | 5068 | 29559675 |
| Injection site pain | 379.99 | 25.67 | 194 | 9590 | 32252 | 29532491 |
| Dysphagia | 243.09 | 25.67 | 176 | 9608 | 54750 | 29509993 |
| Muscular weakness | 198.39 | 25.67 | 164 | 9620 | 61888 | 29502855 |
| Product storage error | 132.37 | 25.67 | 57 | 9727 | 6413 | 29558330 |
| Product preparation issue | 118.00 | 25.67 | 25 | 9759 | 224 | 29564519 |
| Migraine | 115.97 | 25.67 | 64 | 9720 | 12366 | 29552377 |
| Botulism | 109.40 | 25.67 | 22 | 9762 | 148 | 29564595 |
| Poor quality product administered | 107.72 | 25.67 | 34 | 9750 | 1585 | 29563158 |
| Neuromuscular toxicity | 93.09 | 25.67 | 16 | 9768 | 37 | 29564706 |
| Injection site swelling | 67.86 | 25.67 | 41 | 9743 | 9376 | 29555367 |
| Neck pain | 64.85 | 25.67 | 55 | 9729 | 21392 | 29543351 |
| Acute kidney injury | 60.92 | 25.67 | 8 | 9776 | 265259 | 29299484 |
| Facial paresis | 59.75 | 25.67 | 25 | 9759 | 2616 | 29562127 |
| Headache | 59.61 | 25.67 | 158 | 9626 | 173849 | 29390894 |
| Brow ptosis | 56.12 | 25.67 | 8 | 9776 | 0 | 29564743 |
| Drug ineffective for unapproved indication | 52.56 | 25.67 | 41 | 9743 | 14173 | 29550570 |
| Anaemia | 48.74 | 25.67 | 5 | 9779 | 200946 | 29363797 |
| Head discomfort | 45.56 | 25.67 | 22 | 9762 | 3220 | 29561523 |
| Diplopia | 41.53 | 25.67 | 35 | 9749 | 13483 | 29551260 |
| Nightmare | 40.20 | 25.67 | 32 | 9752 | 11385 | 29553358 |
| Therapeutic product effect decreased | 38.36 | 25.67 | 48 | 9736 | 29403 | 29535340 |
| Drug interaction | 36.69 | 25.67 | 10 | 9774 | 197375 | 29367368 |
| Injection site rash | 35.01 | 25.67 | 19 | 9765 | 3545 | 29561198 |
| Toxicity to various agents | 33.81 | 25.67 | 8 | 9776 | 173653 | 29391090 |
| Nephrolithiasis | 32.53 | 25.67 | 41 | 9743 | 25293 | 29539450 |
| Urinary retention | 30.88 | 25.67 | 45 | 9739 | 31853 | 29532890 |
| Sedation | 30.41 | 25.67 | 33 | 9751 | 17372 | 29547371 |
| Diarrhoea | 28.82 | 25.67 | 41 | 9743 | 332657 | 29232086 |
| Residual urine volume increased | 28.06 | 25.67 | 4 | 9780 | 0 | 29564743 |
| Eyelid oedema | 27.88 | 25.67 | 18 | 9766 | 4618 | 29560125 |
| Thrombocytopenia | 26.64 | 25.67 | 6 | 9778 | 134817 | 29429926 |
| Aspiration | 26.52 | 25.67 | 24 | 9760 | 10156 | 29554587 |
| Product distribution issue | 25.87 | 25.67 | 8 | 9776 | 348 | 29564395 |
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Drug ineffective | 8970.66 | 21.42 | 6396 | 45619 | 833851 | 63612866 |
| Product preparation error | 5083.62 | 21.42 | 1058 | 50957 | 2947 | 64443770 |
| Eyelid ptosis | 3269.19 | 21.42 | 872 | 51143 | 8653 | 64438064 |
| Off label use | 2942.06 | 21.42 | 3031 | 48984 | 629775 | 63816942 |
| Therapeutic response decreased | 2895.74 | 21.42 | 1206 | 50809 | 50982 | 64395735 |
| Wrong technique in product usage process | 2138.50 | 21.42 | 1043 | 50972 | 63931 | 64382786 |
| Multiple use of single-use product | 1895.69 | 21.42 | 341 | 51674 | 261 | 64446456 |
| Injection site pain | 1682.39 | 21.42 | 1071 | 50944 | 110337 | 64336380 |
| Facial paresis | 833.51 | 21.42 | 260 | 51755 | 4632 | 64442085 |
| Brow ptosis | 705.89 | 21.42 | 123 | 51892 | 58 | 64446659 |
| Dysphagia | 698.59 | 21.42 | 623 | 51392 | 106189 | 64340528 |
| Muscular weakness | 565.98 | 21.42 | 601 | 51414 | 126737 | 64319980 |
| Injection site swelling | 554.84 | 21.42 | 370 | 51645 | 40983 | 64405734 |
| Poor quality product administered | 548.18 | 21.42 | 171 | 51844 | 3044 | 64443673 |
| Product preparation issue | 527.15 | 21.42 | 122 | 51893 | 622 | 64446095 |
| Drug ineffective for unapproved indication | 520.40 | 21.42 | 320 | 51695 | 30813 | 64415904 |
| Swelling face | 488.77 | 21.42 | 395 | 51620 | 58771 | 64387946 |
| Eye swelling | 442.59 | 21.42 | 256 | 51759 | 22025 | 64424692 |
| Migraine | 414.07 | 21.42 | 368 | 51647 | 62309 | 64384408 |
| Headache | 398.58 | 21.42 | 1127 | 50888 | 528340 | 63918377 |
| Botulism | 392.20 | 21.42 | 84 | 51931 | 277 | 64446440 |
| Product storage error | 390.10 | 21.42 | 198 | 51817 | 13120 | 64433597 |
| Vision blurred | 368.93 | 21.42 | 408 | 51607 | 89908 | 64356809 |
| Eyelid oedema | 352.21 | 21.42 | 180 | 51835 | 12099 | 64434618 |
| Neck pain | 339.92 | 21.42 | 327 | 51688 | 61206 | 64385511 |
| Neuromuscular toxicity | 301.26 | 21.42 | 61 | 51954 | 139 | 64446578 |
| Acute kidney injury | 294.43 | 21.42 | 17 | 51998 | 449223 | 63997494 |
| Therapeutic response shortened | 245.89 | 21.42 | 133 | 51882 | 10037 | 64436680 |
| Anaemia | 237.22 | 21.42 | 18 | 51997 | 378662 | 64068055 |
| Diplopia | 232.14 | 21.42 | 184 | 51831 | 26581 | 64420136 |
| Influenza like illness | 220.09 | 21.42 | 260 | 51755 | 61442 | 64385275 |
| Facial paralysis | 203.38 | 21.42 | 148 | 51867 | 18818 | 64427899 |
| Toxicity to various agents | 202.45 | 21.42 | 27 | 51988 | 363486 | 64083231 |
| Facial asymmetry | 192.95 | 21.42 | 54 | 51961 | 645 | 64446072 |
| Incorrect route of product administration | 191.04 | 21.42 | 155 | 51860 | 23143 | 64423574 |
| Drug interaction | 189.90 | 21.42 | 32 | 51983 | 362051 | 64084666 |
| Injection site rash | 178.30 | 21.42 | 127 | 51888 | 15615 | 64431102 |
| Hypoaesthesia | 172.52 | 21.42 | 360 | 51655 | 138748 | 64307969 |
| Facial pain | 168.21 | 21.42 | 95 | 51920 | 7800 | 64438917 |
| Neutropenia | 166.75 | 21.42 | 6 | 52009 | 239618 | 64207099 |
| Skin tightness | 163.70 | 21.42 | 80 | 51935 | 4881 | 64441836 |
| Pneumonia | 163.00 | 21.42 | 128 | 51887 | 559448 | 63887269 |
| Completed suicide | 162.03 | 21.42 | 4 | 52011 | 224410 | 64222307 |
| Injection site erythema | 159.16 | 21.42 | 238 | 51777 | 70562 | 64376155 |
| Head discomfort | 149.28 | 21.42 | 102 | 51913 | 11732 | 64434985 |
| Injection site mass | 148.18 | 21.42 | 118 | 51897 | 17152 | 64429565 |
| Diarrhoea | 145.88 | 21.42 | 224 | 51791 | 722480 | 63724237 |
| Thrombocytopenia | 144.78 | 21.42 | 9 | 52006 | 223792 | 64222925 |
| Hypotension | 143.41 | 21.42 | 64 | 51951 | 380910 | 64065807 |
| Eyelid sensory disorder | 131.87 | 21.42 | 23 | 51992 | 11 | 64446706 |
| Muscle tightness | 124.32 | 21.42 | 89 | 51926 | 11026 | 64435691 |
| Product quality issue | 123.88 | 21.42 | 136 | 51879 | 29663 | 64417054 |
| Periorbital swelling | 119.48 | 21.42 | 48 | 51967 | 1828 | 64444889 |
| Injection site nodule | 115.38 | 21.42 | 55 | 51960 | 3175 | 64443542 |
| Lagophthalmos | 114.61 | 21.42 | 31 | 51984 | 323 | 64446394 |
| Blepharospasm | 113.08 | 21.42 | 55 | 51960 | 3320 | 64443397 |
| Paraesthesia | 109.93 | 21.42 | 296 | 51719 | 134226 | 64312491 |
| Asthenopia | 108.73 | 21.42 | 46 | 51969 | 2001 | 64444716 |
| Muscle twitching | 108.66 | 21.42 | 103 | 51912 | 18895 | 64427822 |
| Arthralgia | 107.59 | 21.42 | 119 | 51896 | 442141 | 64004576 |
| Renal failure | 107.22 | 21.42 | 11 | 52004 | 181677 | 64265040 |
| Sepsis | 106.93 | 21.42 | 27 | 51988 | 230314 | 64216403 |
| Dry eye | 102.94 | 21.42 | 122 | 51893 | 28897 | 64417820 |
| Injection site bruising | 102.06 | 21.42 | 136 | 51879 | 36237 | 64410480 |
| General physical health deterioration | 100.79 | 21.42 | 21 | 51994 | 204404 | 64242313 |
| Dysphonia | 98.65 | 21.42 | 152 | 51863 | 46230 | 64400487 |
| Product administered at inappropriate site | 96.21 | 21.42 | 48 | 51967 | 3062 | 64443655 |
| Renal impairment | 91.77 | 21.42 | 4 | 52011 | 135013 | 64311704 |
| Injection site urticaria | 90.83 | 21.42 | 74 | 51941 | 11107 | 64435610 |
| Eye pain | 89.88 | 21.42 | 119 | 51896 | 31506 | 64415211 |
| Hypoaesthesia oral | 88.55 | 21.42 | 74 | 51941 | 11506 | 64435211 |
| Haemoglobin decreased | 88.36 | 21.42 | 24 | 51991 | 195039 | 64251678 |
| Blood creatinine increased | 86.18 | 21.42 | 6 | 52009 | 135776 | 64310941 |
| Joint swelling | 86.08 | 21.42 | 33 | 51982 | 215349 | 64231368 |
| Platelet count decreased | 85.24 | 21.42 | 16 | 51999 | 167695 | 64279022 |
| Product distribution issue | 84.48 | 21.42 | 30 | 51985 | 808 | 64445909 |
| Atrial fibrillation | 83.45 | 21.42 | 18 | 51997 | 171071 | 64275646 |
| Oedema peripheral | 82.77 | 21.42 | 33 | 51982 | 210284 | 64236433 |
| Hepatic enzyme increased | 81.73 | 21.42 | 6 | 52009 | 129937 | 64316780 |
| Infusion related reaction | 80.84 | 21.42 | 17 | 51998 | 164450 | 64282267 |
| Cardiac failure congestive | 79.42 | 21.42 | 7 | 52008 | 130573 | 64316144 |
| Gastrointestinal haemorrhage | 78.07 | 21.42 | 8 | 52007 | 132304 | 64314413 |
| Prescribed overdose | 78.00 | 21.42 | 89 | 51926 | 20242 | 64426475 |
| Disease progression | 77.61 | 21.42 | 11 | 52004 | 141669 | 64305048 |
| Periorbital oedema | 77.53 | 21.42 | 57 | 51958 | 7357 | 64439360 |
| Injection site paraesthesia | 76.88 | 21.42 | 25 | 51990 | 511 | 64446206 |
| Hyponatraemia | 75.70 | 21.42 | 14 | 52001 | 148325 | 64298392 |
| Swelling of eyelid | 74.28 | 21.42 | 36 | 51979 | 2156 | 64444561 |
| Myocardial infarction | 73.97 | 21.42 | 21 | 51994 | 165800 | 64280917 |
| Fall | 73.89 | 21.42 | 140 | 51875 | 416686 | 64030031 |
| Cardiac arrest | 73.54 | 21.42 | 17 | 51998 | 154047 | 64292670 |
| Neovascularisation | 72.94 | 21.42 | 29 | 51986 | 1074 | 64445643 |
| Pleural effusion | 71.29 | 21.42 | 9 | 52006 | 126550 | 64320167 |
| Pyrexia | 71.20 | 21.42 | 223 | 51792 | 558421 | 63888296 |
| Cardiac failure | 70.84 | 21.42 | 11 | 52004 | 132362 | 64314355 |
| Speech disorder | 69.09 | 21.42 | 133 | 51882 | 48308 | 64398409 |
| Injection site haemorrhage | 66.91 | 21.42 | 90 | 51925 | 24188 | 64422529 |
| Drug abuse | 66.47 | 21.42 | 13 | 52002 | 132361 | 64314356 |
| Alanine aminotransferase increased | 65.06 | 21.42 | 16 | 51999 | 139015 | 64307702 |
| Infection | 63.50 | 21.42 | 35 | 51980 | 184845 | 64261872 |
| Hypokalaemia | 63.29 | 21.42 | 11 | 52004 | 121892 | 64324825 |
| Burning sensation | 63.19 | 21.42 | 130 | 51885 | 49534 | 64397183 |
| Arthropathy | 62.62 | 21.42 | 11 | 52004 | 120956 | 64325761 |
| Product packaging issue | 62.15 | 21.42 | 25 | 51990 | 955 | 64445762 |
| Confusional state | 61.51 | 21.42 | 72 | 51943 | 261072 | 64185645 |
| Aspartate aminotransferase increased | 59.64 | 21.42 | 12 | 52003 | 119776 | 64326941 |
| Throat tightness | 59.51 | 21.42 | 83 | 51932 | 23077 | 64423640 |
| Muscle spasms | 58.47 | 21.42 | 247 | 51768 | 140776 | 64305941 |
| Contraindicated product administered | 57.60 | 21.42 | 9 | 52006 | 107820 | 64338897 |
| Abdominal pain | 57.01 | 21.42 | 103 | 51912 | 312272 | 64134445 |
| Lacrimation increased | 56.76 | 21.42 | 72 | 51943 | 18274 | 64428443 |
| Dehydration | 56.35 | 21.42 | 55 | 51960 | 216708 | 64230009 |
| Rheumatoid arthritis | 55.13 | 21.42 | 32 | 51983 | 164262 | 64282455 |
| Central nervous system function test abnormal | 55.11 | 21.42 | 9 | 52006 | 0 | 64446717 |
| Intentional overdose | 54.21 | 21.42 | 5 | 52010 | 89939 | 64356778 |
| Multiple organ dysfunction syndrome | 52.97 | 21.42 | 9 | 52006 | 101404 | 64345313 |
| Injection site discomfort | 52.17 | 21.42 | 36 | 51979 | 4205 | 64442512 |
| Decreased appetite | 51.99 | 21.42 | 92 | 51923 | 281197 | 64165520 |
| Condition aggravated | 51.47 | 21.42 | 143 | 51872 | 372283 | 64074434 |
| Maternal exposure during pregnancy | 51.22 | 21.42 | 8 | 52007 | 95876 | 64350841 |
| Overdose | 51.01 | 21.42 | 259 | 51756 | 159307 | 64287410 |
| Photophobia | 50.57 | 21.42 | 66 | 51949 | 17227 | 64429490 |
| White blood cell count decreased | 49.83 | 21.42 | 33 | 51982 | 157804 | 64288913 |
| Hypertension | 49.55 | 21.42 | 83 | 51932 | 259178 | 64187539 |
| Ocular discomfort | 49.32 | 21.42 | 34 | 51981 | 3965 | 64442752 |
| Post-traumatic neck syndrome | 49.13 | 21.42 | 26 | 51989 | 1876 | 64444841 |
| Bradycardia | 49.09 | 21.42 | 17 | 51998 | 118202 | 64328515 |
| Strabismus | 49.02 | 21.42 | 27 | 51988 | 2110 | 64444607 |
| Mastication disorder | 48.98 | 21.42 | 28 | 51987 | 2351 | 64444366 |
| International normalised ratio increased | 48.80 | 21.42 | 4 | 52011 | 79163 | 64367554 |
| Leukopenia | 48.65 | 21.42 | 11 | 52004 | 101231 | 64345486 |
| Neuropathy peripheral | 48.63 | 21.42 | 17 | 51998 | 117508 | 64329209 |
| Pulmonary embolism | 48.40 | 21.42 | 29 | 51986 | 146327 | 64300390 |
| Ophthalmoplegia | 48.25 | 21.42 | 29 | 51986 | 2673 | 64444044 |
| Death | 48.14 | 21.42 | 213 | 51802 | 482492 | 63964225 |
| Urticaria | 47.71 | 21.42 | 240 | 51775 | 147077 | 64299640 |
| Abdominal discomfort | 47.68 | 21.42 | 46 | 51969 | 182276 | 64264441 |
| Eye irritation | 47.12 | 21.42 | 61 | 51954 | 15795 | 64430922 |
| Peripheral swelling | 46.77 | 21.42 | 60 | 51955 | 209093 | 64237624 |
| Electrocardiogram QT prolonged | 46.35 | 21.42 | 5 | 52010 | 79443 | 64367274 |
| Drug effect less than expected | 46.14 | 21.42 | 17 | 51998 | 510 | 64446207 |
| Erythema of eyelid | 45.52 | 21.42 | 25 | 51990 | 1943 | 64444774 |
| Suicide attempt | 45.45 | 21.42 | 3 | 52012 | 71004 | 64375713 |
| Product reconstitution quality issue | 45.23 | 21.42 | 13 | 52002 | 172 | 64446545 |
| Systemic lupus erythematosus | 44.99 | 21.42 | 5 | 52010 | 77607 | 64369110 |
| Dry mouth | 44.41 | 21.42 | 128 | 51887 | 60290 | 64386427 |
| Feeling abnormal | 44.20 | 21.42 | 219 | 51796 | 133383 | 64313334 |
| Eye discharge | 44.16 | 21.42 | 35 | 51980 | 5049 | 64441668 |
| Rhabdomyolysis | 44.00 | 21.42 | 10 | 52005 | 91716 | 64355001 |
| Patient dissatisfaction with treatment | 43.86 | 21.42 | 12 | 52003 | 131 | 64446586 |
| Injection site oedema | 43.55 | 21.42 | 20 | 51995 | 1060 | 64445657 |
| Pulmonary oedema | 43.33 | 21.42 | 6 | 52009 | 78668 | 64368049 |
| Manufacturing product shipping issue | 43.15 | 21.42 | 11 | 52004 | 89 | 64446628 |
| Drug hypersensitivity | 42.84 | 21.42 | 79 | 51936 | 237736 | 64208981 |
| Hypoglycaemia | 42.72 | 21.42 | 10 | 52005 | 89882 | 64356835 |
| Nerve injury | 42.68 | 21.42 | 41 | 51974 | 7644 | 64439073 |
| Septic shock | 42.35 | 21.42 | 16 | 51999 | 105421 | 64341296 |
| Facial spasm | 42.12 | 21.42 | 17 | 51998 | 655 | 64446062 |
| Accidental exposure to product | 42.10 | 21.42 | 76 | 51939 | 26288 | 64420429 |
| Stomatitis | 41.79 | 21.42 | 18 | 51997 | 109587 | 64337130 |
| Vomiting | 41.69 | 21.42 | 267 | 51748 | 550850 | 63895867 |
| Paralysis | 41.53 | 21.42 | 49 | 51966 | 11546 | 64435171 |
| Vertigo | 41.44 | 21.42 | 123 | 51892 | 58888 | 64387829 |
| Coma | 41.14 | 21.42 | 10 | 52005 | 87605 | 64359112 |
| Weight increased | 41.03 | 21.42 | 68 | 51947 | 213280 | 64233437 |
| Abnormal sensation in eye | 40.11 | 21.42 | 22 | 51993 | 1705 | 64445012 |
| Metabolic acidosis | 40.06 | 21.42 | 5 | 52010 | 70953 | 64375764 |
| Neutrophil count decreased | 39.99 | 21.42 | 7 | 52008 | 77189 | 64369528 |
| Tension headache | 39.93 | 21.42 | 28 | 51987 | 3355 | 64443362 |
| Eye pruritus | 39.66 | 21.42 | 50 | 51965 | 12609 | 64434108 |
| Hypoxia | 39.60 | 21.42 | 11 | 52004 | 88138 | 64358579 |
| Soft tissue injury | 39.14 | 21.42 | 21 | 51994 | 1558 | 64445159 |
| Pericarditis | 38.97 | 21.42 | 3 | 52012 | 62513 | 64384204 |
| Agitation | 37.92 | 21.42 | 12 | 52003 | 88355 | 64358362 |
| Injection site pruritus | 37.91 | 21.42 | 90 | 51925 | 37736 | 64408981 |
| Hepatic function abnormal | 37.64 | 21.42 | 4 | 52011 | 64309 | 64382408 |
| Blood glucose increased | 37.56 | 21.42 | 16 | 51999 | 98057 | 64348660 |
| Endometriosis | 37.44 | 21.42 | 25 | 51990 | 2767 | 64443950 |
| Wound | 37.36 | 21.42 | 8 | 52007 | 76469 | 64370248 |
| Cough | 36.72 | 21.42 | 123 | 51892 | 302025 | 64144692 |
| Libido increased | 36.67 | 21.42 | 21 | 51994 | 1769 | 64444948 |
| Cardio-respiratory arrest | 36.20 | 21.42 | 17 | 51998 | 98376 | 64348341 |
| Inappropriate schedule of product administration | 36.19 | 21.42 | 159 | 51856 | 92127 | 64354590 |
| Drug specific antibody | 36.16 | 21.42 | 22 | 51993 | 2073 | 64444644 |
| Injection site haematoma | 36.14 | 21.42 | 28 | 51987 | 3908 | 64442809 |
| Ocular hyperaemia | 35.97 | 21.42 | 65 | 51950 | 22499 | 64424218 |
| Muscle spasticity | 35.95 | 21.42 | 55 | 51960 | 16614 | 64430103 |
| Lip swelling | 35.38 | 21.42 | 79 | 51936 | 31828 | 64414889 |
| Choking | 35.23 | 21.42 | 43 | 51972 | 10495 | 64436222 |
| Hostility | 35.10 | 21.42 | 22 | 51993 | 2185 | 64444532 |
| Injection site hypoaesthesia | 34.97 | 21.42 | 13 | 52002 | 400 | 64446317 |
| Visual impairment | 34.86 | 21.42 | 135 | 51880 | 73942 | 64372775 |
| Nasopharyngitis | 34.54 | 21.42 | 66 | 51949 | 196007 | 64250710 |
| Application site acne | 34.31 | 21.42 | 6 | 52009 | 3 | 64446714 |
| Product temperature excursion issue | 34.07 | 21.42 | 9 | 52006 | 85 | 64446632 |
| Diaphragmatic rupture | 34.05 | 21.42 | 11 | 52004 | 220 | 64446497 |
| Lid sulcus deepened | 33.88 | 21.42 | 10 | 52005 | 146 | 64446571 |
| Colitis | 33.45 | 21.42 | 4 | 52011 | 58670 | 64388047 |
| Deep vein thrombosis | 33.17 | 21.42 | 22 | 51993 | 105160 | 64341557 |
| Dermatochalasis | 32.59 | 21.42 | 6 | 52009 | 6 | 64446711 |
| Dizziness | 32.54 | 21.42 | 507 | 51508 | 429656 | 64017061 |
| Lower respiratory tract infection | 32.34 | 21.42 | 18 | 51997 | 94596 | 64352121 |
| Haematochezia | 32.31 | 21.42 | 7 | 52008 | 66366 | 64380351 |
| Sternal fracture | 32.27 | 21.42 | 21 | 51994 | 2226 | 64444491 |
| Eyelid pain | 32.01 | 21.42 | 11 | 52004 | 268 | 64446449 |
| Injection site inflammation | 31.97 | 21.42 | 24 | 51991 | 3197 | 64443520 |
| Rectal haemorrhage | 31.17 | 21.42 | 6 | 52009 | 61811 | 64384906 |
| Vascular malformation | 31.16 | 21.42 | 11 | 52004 | 291 | 64446426 |
| C-reactive protein increased | 31.10 | 21.42 | 19 | 51996 | 94890 | 64351827 |
| Paradoxical drug reaction | 30.91 | 21.42 | 31 | 51984 | 6089 | 64440628 |
| Respiratory failure | 30.40 | 21.42 | 52 | 51963 | 161131 | 64285586 |
| Cerebral haemorrhage | 30.36 | 21.42 | 3 | 52012 | 51087 | 64395630 |
| Epistaxis | 30.31 | 21.42 | 21 | 51994 | 98110 | 64348607 |
| Impaired healing | 30.21 | 21.42 | 6 | 52009 | 60467 | 64386250 |
| Chronic obstructive pulmonary disease | 29.86 | 21.42 | 10 | 52005 | 71038 | 64375679 |
| Liver function test abnormal | 29.46 | 21.42 | 6 | 52009 | 59395 | 64387322 |
| Madarosis | 29.18 | 21.42 | 20 | 51995 | 2310 | 64444407 |
| Injection site indentation | 29.01 | 21.42 | 9 | 52006 | 157 | 64446560 |
| Acute myocardial infarction | 28.98 | 21.42 | 10 | 52005 | 69708 | 64377009 |
| Delirium | 28.63 | 21.42 | 10 | 52005 | 69184 | 64377533 |
| Lung disorder | 28.35 | 21.42 | 7 | 52008 | 60693 | 64386024 |
| Eyelid contusion | 28.27 | 21.42 | 5 | 52010 | 3 | 64446714 |
| Blood bilirubin increased | 28.15 | 21.42 | 6 | 52009 | 57547 | 64389170 |
| Vitreous floaters | 28.07 | 21.42 | 30 | 51985 | 6343 | 64440374 |
| Thrombosis | 27.90 | 21.42 | 11 | 52004 | 70631 | 64376086 |
| Drug-induced liver injury | 27.78 | 21.42 | 3 | 52012 | 47640 | 64399077 |
| Bronchitis | 27.76 | 21.42 | 28 | 51987 | 108715 | 64338002 |
| Anxiety | 27.60 | 21.42 | 267 | 51748 | 202382 | 64244335 |
| Rash maculo-papular | 27.33 | 21.42 | 3 | 52012 | 47023 | 64399694 |
| Eyelid disorder | 27.23 | 21.42 | 16 | 51999 | 1415 | 64445302 |
| Depressed level of consciousness | 27.10 | 21.42 | 16 | 51999 | 81420 | 64365297 |
| Diabetes mellitus | 26.84 | 21.42 | 10 | 52005 | 66464 | 64380253 |
| Mental status changes | 26.79 | 21.42 | 8 | 52007 | 61154 | 64385563 |
| Skin wrinkling | 26.78 | 21.42 | 14 | 52001 | 985 | 64445732 |
| Haemoptysis | 26.40 | 21.42 | 4 | 52011 | 49044 | 64397673 |
| Lip disorder | 26.39 | 21.42 | 15 | 52000 | 1246 | 64445471 |
| Paranasal cyst | 26.13 | 21.42 | 10 | 52005 | 334 | 64446383 |
| Angina pectoris | 25.88 | 21.42 | 3 | 52012 | 45078 | 64401639 |
| Product quality control issue | 25.85 | 21.42 | 5 | 52010 | 8 | 64446709 |
| Fluid retention | 25.74 | 21.42 | 8 | 52007 | 59598 | 64387119 |
| Glossodynia | 25.67 | 21.42 | 10 | 52005 | 64686 | 64382031 |
| Transaminases increased | 25.52 | 21.42 | 3 | 52012 | 44591 | 64402126 |
| Blood alkaline phosphatase increased | 25.32 | 21.42 | 7 | 52008 | 56272 | 64390445 |
| Product dose omission issue | 25.23 | 21.42 | 77 | 51938 | 194670 | 64252047 |
| Liver disorder | 25.22 | 21.42 | 6 | 52009 | 53345 | 64393372 |
| Blood urea increased | 25.20 | 21.42 | 3 | 52012 | 44150 | 64402567 |
| Unresponsive to stimuli | 25.18 | 21.42 | 5 | 52010 | 50388 | 64396329 |
| Eye contusion | 24.96 | 21.42 | 17 | 51998 | 1944 | 64444773 |
| Haematemesis | 24.92 | 21.42 | 4 | 52011 | 46995 | 64399722 |
| Treatment noncompliance | 24.70 | 21.42 | 3 | 52012 | 43479 | 64403238 |
| Intranasal hypoaesthesia | 24.50 | 21.42 | 4 | 52011 | 0 | 64446717 |
| Nightmare | 24.43 | 21.42 | 53 | 51962 | 20940 | 64425777 |
| Pancreatitis | 24.01 | 21.42 | 9 | 52006 | 59598 | 64387119 |
| Dyspnoea exertional | 23.82 | 21.42 | 15 | 52000 | 73715 | 64373002 |
| Oxygen saturation decreased | 23.68 | 21.42 | 31 | 51984 | 107145 | 64339572 |
| Facial discomfort | 23.60 | 21.42 | 6 | 52009 | 48 | 64446669 |
| Encephalopathy | 23.49 | 21.42 | 9 | 52006 | 58810 | 64387907 |
| Skin indentation | 23.46 | 21.42 | 5 | 52010 | 16 | 64446701 |
| Drooling | 23.36 | 21.42 | 25 | 51990 | 5294 | 64441423 |
| Eyelids pruritus | 23.30 | 21.42 | 11 | 52004 | 621 | 64446096 |
| Ear discomfort | 23.20 | 21.42 | 29 | 51986 | 7251 | 64439466 |
| Haemorrhage | 23.18 | 21.42 | 18 | 51997 | 79333 | 64367384 |
| Procedural anxiety | 23.02 | 21.42 | 11 | 52004 | 638 | 64446079 |
| Haematuria | 22.94 | 21.42 | 10 | 52005 | 60461 | 64386256 |
| Injection site granuloma | 22.78 | 21.42 | 6 | 52009 | 56 | 64446661 |
| Blood pressure systolic increased | 22.53 | 21.42 | 6 | 52009 | 49447 | 64397270 |
| Muscle atrophy | 22.18 | 21.42 | 33 | 51982 | 9725 | 64436992 |
| Pancreatitis acute | 21.94 | 21.42 | 4 | 52011 | 42851 | 64403866 |
| White blood cell count increased | 21.93 | 21.42 | 13 | 52002 | 66001 | 64380716 |
| Gastrointestinal disorder | 21.89 | 21.42 | 24 | 51991 | 89685 | 64357032 |
| Gamma-glutamyltransferase increased | 21.88 | 21.42 | 6 | 52009 | 48504 | 64398213 |
| Vestibular migraine | 21.71 | 21.42 | 7 | 52008 | 139 | 64446578 |
| Serotonin syndrome | 21.62 | 21.42 | 3 | 52012 | 39279 | 64407438 |
| Pericardial effusion | 21.60 | 21.42 | 3 | 52012 | 39251 | 64407466 |
| Cutis laxa | 21.57 | 21.42 | 7 | 52008 | 142 | 64446575 |
| Dysarthria | 21.52 | 21.42 | 100 | 51915 | 59306 | 64387411 |
None
| Source | Code | Description |
|---|---|---|
| MeSH PA | D065087 | Acetylcholine Release Inhibitors |
| MeSH PA | D018678 | Cholinergic Agents |
| MeSH PA | D049990 | Membrane Transport Modulators |
| MeSH PA | D009465 | Neuromuscular Agents |
| MeSH PA | D009498 | Neurotoxins |
| MeSH PA | D018377 | Neurotransmitter Agents |
| MeSH PA | D009676 | Noxae |
| MeSH PA | D018373 | Peripheral Nervous System Agents |
| FDA PE | N0000175731 | Neuromuscular Blockade |
| FDA MoA | N0000175770 | Acetylcholine Release Inhibitors |
| FDA EPC | N0000175771 | Acetylcholine Release Inhibitor |
| FDA EPC | N0000193962 | Neuromuscular Blocker |
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Rhytidectomy of glabellar frown lines | indication | 14667004 | |
| Urge urinary incontinence | indication | 87557004 | |
| Urinary frequency | indication | 162116003 | |
| Lower limb spasticity | indication | 394679006 | |
| Upper limb spasticity | indication | 394680009 | |
| Neurogenic bladder | indication | 398064005 | |
| Overactive bladder | indication | 786457000 |
None
None
None
None
None
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Synaptosomal-associated protein 25 | Cytosolic other | BLOCKER | SCIENTIFIC LITERATURE | SCIENTIFIC LITERATURE |
| ID | Source |
|---|---|
| CHEBI:3160 | CHEBI |
| CHEMBL4297862 | ChEMBL_ID |
| D00783 | KEGG_DRUG |
| C545476 | MESH_SUPPLEMENTAL_RECORD_UI |
| 93384-43-1 | SECONDARY_CAS_RN |
| DB00083 | DRUGBANK_ID |
| E211KPY694 | UNII |
| 1000104 | RXNORM |
| 27317 | MMSL |
| 4295 | MMSL |
| d01227 | MMSL |
| d07669 | MMSL |
| 108890005 | SNOMEDCT_US |
| 427412002 | SNOMEDCT_US |
| 703368006 | SNOMEDCT_US |
| 772950004 | SNOMEDCT_US |
| 4020561 | VANDF |
| 4030130 | VANDF |
| C0006050 | UMLSCUI |
| CHEMBL2108035 | ChEMBL_ID |
| 013287 | NDDF |
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| BOTOX | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0023-1145 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 100 [USPU] | INTRADERMAL | BLA | 30 sections |
| BOTOX Cosmetic | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0023-3919 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 50 [USPU] | INTRAMUSCULAR | BLA | 30 sections |
| BOTOX | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0023-3921 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 200 [USPU] | INTRADERMAL | BLA | 30 sections |
| BOTOX Cosmetic | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0023-9232 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 100 [USPU] | INTRAMUSCULAR | BLA | 30 sections |
| Xeomin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0259-1605 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 50 [USPU] | INTRAMUSCULAR | BLA | 31 sections |
| Xeomin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0259-1610 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 100 [USPU] | INTRAMUSCULAR | BLA | 31 sections |
| Xeomin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0259-1620 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 200 [USPU] | INTRAMUSCULAR | BLA | 31 sections |
| Xeomin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0259-4110 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 100 [USPU] | INTRAMUSCULAR | BLA | 31 sections |
| Xeomin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0259-4150 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 50 [USPU] | INTRAMUSCULAR | BLA | 31 sections |
| Dysport | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0299-5962 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 300 U | INTRAMUSCULAR | BLA | 33 sections |
| Dysport | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0299-5962 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 300 U | INTRAMUSCULAR | BLA | 33 sections |
| Dysport | HUMAN PRESCRIPTION DRUG LABEL | 1 | 15054-0500 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 500 U | INTRAMUSCULAR | BLA | 31 sections |
| Dysport | HUMAN PRESCRIPTION DRUG LABEL | 1 | 15054-0530 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 300 U | INTRAMUSCULAR | BLA | 31 sections |
| Xeomin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 46783-160 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 100 [USPU] | INTRAMUSCULAR | BLA | 31 sections |
| Xeomin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 46783-161 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 50 [USPU] | INTRAMUSCULAR | BLA | 31 sections |
| Xeomin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 46783-165 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 50 [USPU] | INTRAMUSCULAR | BLA | 31 sections |
| Jeuveau | HUMAN PRESCRIPTION DRUG LABEL | 1 | 72301-595 | POWDER | 100 [USPU] | INTRAMUSCULAR | BLA | 28 sections |