Stem definition | Drug id | CAS RN |
---|---|---|
orexin receptor antagonists | 5360 | 1369764-02-2 |
None
Property | Value | Reference |
---|---|---|
S (Water solubility) | 0.03 mg/mL | Bocci G, Oprea TI, Benet LZ |
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 2 | Bocci G, Oprea TI, Benet LZ |
Date | Agency | Company | Orphan |
---|---|---|---|
Dec. 20, 2019 | FDA | EISAI INC | |
Jan. 23, 2020 | PMDA | Eisai Co., Ltd |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Sleep paralysis | 279.06 | 41.21 | 36 | 530 | 624 | 63487832 |
Nightmare | 57.00 | 41.21 | 16 | 550 | 19178 | 63469278 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Sleep paralysis | 108.79 | 34.75 | 14 | 406 | 170 | 34956341 |
Nightmare | 70.89 | 34.75 | 19 | 401 | 14372 | 34942139 |
Abnormal dreams | 51.79 | 34.75 | 13 | 407 | 7565 | 34948946 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Sleep paralysis | 154.77 | 28.88 | 22 | 880 | 616 | 79742870 |
Nightmare | 56.62 | 28.88 | 18 | 884 | 25843 | 79717643 |
Pneumonia aspiration | 33.69 | 28.88 | 16 | 886 | 66951 | 79676535 |
Altered state of consciousness | 33.37 | 28.88 | 14 | 888 | 43808 | 79699678 |
Abnormal dreams | 29.37 | 28.88 | 9 | 893 | 11403 | 79732083 |
None
Source | Code | Description |
---|---|---|
ATC | N05CM21 | NERVOUS SYSTEM PSYCHOLEPTICS HYPNOTICS AND SEDATIVES Other hypnotics and sedatives |
MeSH PA | D002491 | Central Nervous System Agents |
MeSH PA | D002492 | Central Nervous System Depressants |
MeSH PA | D006993 | Hypnotics and Sedatives |
MeSH PA | D018377 | Neurotransmitter Agents |
MeSH PA | D000068796 | Orexin Receptor Antagonists |
MeSH PA | D000068776 | Sleep Aids, Pharmaceutical |
FDA MoA | N0000187064 | Cytochrome P450 2B6 Inducers |
FDA MoA | N0000190998 | Orexin Receptor Antagonists |
FDA EPC | N0000191000 | Orexin Receptor Antagonist |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Insomnia | indication | 193462001 | |
Narcolepsy | contraindication | 60380001 | DOID:8986 |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 10.22 | acidic |
pKa2 | 4.56 | Basic |
pKa3 | 1.71 | Basic |
Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Patent number | Patent expiration date | Patent use |
---|---|---|---|---|---|---|---|---|---|---|
10MG | DAYVIGO | EISAI INC | N212028 | April 7, 2020 | RX | TABLET | ORAL | 8268848 | Sept. 20, 2031 | TREATMENT OF ADULT PATIENTS WITH INSOMNIA, CHARACTERIZED BY DIFFICULTIES WITH SLEEP ONSET AND/OR SLEEP MAINTENANCE |
5MG | DAYVIGO | EISAI INC | N212028 | April 7, 2020 | RX | TABLET | ORAL | 8268848 | Sept. 20, 2031 | TREATMENT OF ADULT PATIENTS WITH INSOMNIA, CHARACTERIZED BY DIFFICULTIES WITH SLEEP ONSET AND/OR SLEEP MAINTENANCE |
10MG | DAYVIGO | EISAI INC | N212028 | April 7, 2020 | RX | TABLET | ORAL | 10188652 | Oct. 21, 2035 | TREATMENT OF ADULT PATIENTS WITH INSOMNIA, CHARACTERIZED BY DIFFICULTIES WITH SLEEP ONSET AND/OR SLEEP MAINTENANCE |
5MG | DAYVIGO | EISAI INC | N212028 | April 7, 2020 | RX | TABLET | ORAL | 10188652 | Oct. 21, 2035 | TREATMENT OF ADULT PATIENTS WITH INSOMNIA, CHARACTERIZED BY DIFFICULTIES WITH SLEEP ONSET AND/OR SLEEP MAINTENANCE |
Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Exclusivity date | Description |
---|---|---|---|---|---|---|---|---|---|
10MG | DAYVIGO | EISAI INC | N212028 | April 7, 2020 | RX | TABLET | ORAL | April 7, 2025 | NEW CHEMICAL ENTITY |
5MG | DAYVIGO | EISAI INC | N212028 | April 7, 2020 | RX | TABLET | ORAL | April 7, 2025 | NEW CHEMICAL ENTITY |
10MG | DAYVIGO | EISAI INC | N212028 | April 7, 2020 | RX | TABLET | ORAL | April 20, 2026 | REVISIONS TO THE LABELING TO INCLUDE RESULTS FROM CLINICAL STUDY E2006-A001-113 |
5MG | DAYVIGO | EISAI INC | N212028 | April 7, 2020 | RX | TABLET | ORAL | April 20, 2026 | REVISIONS TO THE LABELING TO INCLUDE RESULTS FROM CLINICAL STUDY E2006-A001-113 |
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Orexin receptor type 1 | GPCR | ANTAGONIST | Ki | 8.22 | DRUG LABEL | DRUG LABEL | |||
Orexin receptor type 2 | GPCR | ANTAGONIST | Ki | 8.52 | DRUG LABEL | DRUG LABEL | |||
Potassium voltage-gated channel subfamily H member 2 | Ion channel | IC50 | 5.21 | CHEMBL |
ID | Source |
---|---|
NRK | PDB_CHEM_ID |
CHEMBL3545367 | ChEMBL_ID |
D11022 | KEGG_DRUG |
C000634104 | MESH_SUPPLEMENTAL_RECORD_UI |
9302 | IUPHAR_LIGAND_ID |
DB11951 | DRUGBANK_ID |
018242 | NDDF |
838465007 | SNOMEDCT_US |
838492001 | SNOMEDCT_US |
4039370 | VANDF |
C4519269 | UMLSCUI |
9988 | INN_ID |
56944144 | PUBCHEM_CID |
2272403 | RXNORM |
334297 | MMSL |
38462 | MMSL |
d09561 | MMSL |
0K5743G68X | UNII |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
DAYVIGO | HUMAN PRESCRIPTION DRUG LABEL | 1 | 62856-405 | TABLET, FILM COATED | 5 mg | ORAL | NDA | 36 sections |
DAYVIGO | HUMAN PRESCRIPTION DRUG LABEL | 1 | 62856-405 | TABLET, FILM COATED | 5 mg | ORAL | NDA | 36 sections |
DAYVIGO | HUMAN PRESCRIPTION DRUG LABEL | 1 | 62856-405 | TABLET, FILM COATED | 5 mg | ORAL | NDA | 36 sections |
DAYVIGO | HUMAN PRESCRIPTION DRUG LABEL | 1 | 62856-410 | TABLET, FILM COATED | 10 mg | ORAL | NDA | 36 sections |
DAYVIGO | HUMAN PRESCRIPTION DRUG LABEL | 1 | 62856-410 | TABLET, FILM COATED | 10 mg | ORAL | NDA | 36 sections |
DAYVIGO | HUMAN PRESCRIPTION DRUG LABEL | 1 | 62856-410 | TABLET, FILM COATED | 10 mg | ORAL | NDA | 36 sections |
DAYVIGO | HUMAN PRESCRIPTION DRUG LABEL | 1 | 62856-455 | TABLET, FILM COATED | 5 mg | ORAL | NDA | 36 sections |
DAYVIGO | HUMAN PRESCRIPTION DRUG LABEL | 1 | 62856-455 | TABLET, FILM COATED | 5 mg | ORAL | NDA | 36 sections |
DAYVIGO | HUMAN PRESCRIPTION DRUG LABEL | 1 | 62856-455 | TABLET, FILM COATED | 5 mg | ORAL | NDA | 36 sections |