cefepime 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
antibiotics, cefalosporanic acid derivatives 535 88040-23-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • cefepime dihydrochloride hydrate
  • cefepime
  • cefepime hydrochloride
  • cefimen
  • tsefepim
  • cefepime HCl
A fourth-generation cephalosporin antibacterial agent that is used in the treatment of infections, including those of the abdomen, urinary tract, respiratory tract, and skin. It is effective against PSEUDOMONAS AERUGINOSA and may also be used in the empiric treatment of FEBRILE NEUTROPENIA.
  • Molecular weight: 480.56
  • Formula: C19H24N6O5S2
  • CLOGP: -4.87
  • LIPINSKI: 1
  • HAC: 11
  • HDO: 2
  • TPSA: 150.04
  • ALOGS: -4.49
  • ROTB: 7

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
4 g P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 3 Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 85 % Benet LZ, Broccatelli F, Oprea TI
BA (Bioavailability) 99 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 0.28 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 2.20 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.78 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 1.90 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Jan. 18, 1996 FDA HOSPIRA INC

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Encephalopathy 462.19 18.80 217 16214 38403 63434188
Acute kidney injury 337.13 18.80 376 16055 263039 63209552
Febrile neutropenia 294.20 18.80 244 16187 118205 63354386
Neurotoxicity 239.25 18.80 107 16324 16883 63455708
Drug reaction with eosinophilia and systemic symptoms 219.15 18.80 126 16305 33710 63438881
Status epilepticus 208.31 18.80 94 16337 15139 63457452
Multiple organ dysfunction syndrome 172.95 18.80 132 16299 56620 63415971
Cytokine release syndrome 160.51 18.80 77 16354 14237 63458354
Myoclonus 144.22 18.80 74 16357 15794 63456797
Sepsis 143.44 18.80 187 16244 152936 63319655
Acute generalised exanthematous pustulosis 140.74 18.80 65 16366 11034 63461557
Pyrexia 137.61 18.80 345 16086 470133 63002458
Septic shock 132.32 18.80 121 16310 66508 63406083
Thrombocytopenia 131.41 18.80 178 16253 150979 63321612
Mental status changes 107.37 18.80 86 16345 39513 63433078
Pain 103.18 18.80 32 16399 740596 62731995
Respiratory failure 100.94 18.80 128 16303 101730 63370861
Toxic encephalopathy 91.19 18.80 41 16390 6538 63466053
Tubulointerstitial nephritis 87.67 18.80 58 16373 19845 63452746
Neutropenia 85.10 18.80 158 16273 174847 63297744
Arthralgia 80.34 18.80 24 16407 569686 62902905
Clostridium difficile colitis 76.51 18.80 54 16377 20515 63452076
Immune effector cell-associated neurotoxicity syndrome 73.07 18.80 26 16405 2251 63470340
Fatigue 72.71 18.80 74 16357 887954 62584637
Klebsiella infection 69.40 18.80 37 16394 8529 63464062
Neutrophil count decreased 67.44 18.80 78 16353 56328 63416263
Pneumonia 66.17 18.80 263 16168 456504 63016087
Shock 65.81 18.80 52 16379 23411 63449180
Abdominal discomfort 64.18 18.80 5 16426 320880 63151711
Platelet count decreased 62.98 18.80 110 16321 116012 63356579
Alopecia 62.88 18.80 7 16424 337529 63135062
Hypoxia 62.15 18.80 77 16354 59715 63412876
Drug resistance 60.43 18.80 49 16382 22884 63449707
Bacteraemia 58.69 18.80 43 16388 17305 63455286
Pathogen resistance 58.59 18.80 30 16401 6368 63466223
Renal tubular necrosis 55.69 18.80 36 16395 11842 63460749
Mixed liver injury 54.67 18.80 26 16405 4709 63467882
Nasopharyngitis 53.66 18.80 3 16428 254254 63218337
Drug intolerance 53.63 18.80 8 16423 308653 63163938
Acute respiratory distress syndrome 53.15 18.80 46 16385 23488 63449103
Pancytopenia 50.19 18.80 90 16341 96843 63375748
Headache 49.20 18.80 55 16376 633186 62839405
Rheumatoid arthritis 47.92 18.80 5 16426 253814 63218777
Fungaemia 46.60 18.80 19 16412 2384 63470207
Aspartate aminotransferase increased 45.69 18.80 83 16348 90194 63382397
Cytomegalovirus test positive 45.65 18.80 20 16411 2998 63469593
Hypotension 45.16 18.80 164 16267 272440 63200151
Malaise 43.51 18.80 27 16404 415927 63056664
Eosinophilia 42.56 18.80 40 16391 22716 63449875
Clostridium difficile infection 41.98 18.80 45 16386 29877 63442714
Cholestatic liver injury 41.77 18.80 18 16413 2592 63469999
Dizziness 40.85 18.80 31 16400 429894 63042697
Systemic lupus erythematosus 39.73 18.80 4 16427 208914 63263677
Trichosporon infection 38.93 18.80 10 16421 282 63472309
Drug ineffective for unapproved indication 38.86 18.80 46 16385 34017 63438574
Renal impairment 38.23 18.80 76 16355 88279 63384312
Respiratory distress 37.33 18.80 45 16386 33906 63438685
Enterococcal infection 37.31 18.80 24 16407 7824 63464767
Renal failure 37.02 18.80 89 16342 117563 63355028
Mucormycosis 36.97 18.80 17 16414 2854 63469737
Swelling 36.25 18.80 13 16418 275365 63197226
Blood creatinine increased 36.15 18.80 74 16357 87770 63384821
Peripheral swelling 35.96 18.80 12 16419 265930 63206661
Therapeutic product effect decreased 35.96 18.80 4 16427 193183 63279408
Stenotrophomonas infection 35.83 18.80 15 16416 2012 63470579
Agranulocytosis 35.61 18.80 38 16393 25096 63447495
Nephropathy toxic 35.51 18.80 25 16406 9454 63463137
Bronchopulmonary aspergillosis 35.22 18.80 24 16407 8611 63463980
Weight decreased 34.88 18.80 14 16417 276784 63195807
Rash maculo-papular 34.62 18.80 42 16389 31854 63440737
Product dose omission issue 34.55 18.80 9 16422 234304 63238287
White blood cell count decreased 34.27 18.80 96 16335 139008 63333583
Alanine aminotransferase increased 34.27 18.80 80 16351 103690 63368901
Pseudomonas infection 33.93 18.80 26 16405 11187 63461404
Acute respiratory failure 33.57 18.80 43 16388 34442 63438149
Metabolic encephalopathy 33.27 18.80 20 16411 5789 63466802
Differentiation syndrome 33.15 18.80 12 16419 1091 63471500
Hepatic function abnormal 32.58 18.80 44 16387 37098 63435493
Antibiotic level above therapeutic 31.89 18.80 9 16422 365 63472226
Anaemia 31.72 18.80 155 16276 293275 63179316
Leukopenia 31.67 18.80 65 16366 77225 63395366
Nephritis allergic 31.51 18.80 8 16423 215 63472376
Sinusitis 31.04 18.80 10 16421 226643 63245948
Encephalitis Japanese B 30.73 18.80 6 16425 45 63472546
Toxic epidermal necrolysis 30.20 18.80 35 16396 25299 63447292
Hypertensive heart disease 29.95 18.80 14 16417 2438 63470153
Enterococcal bacteraemia 29.89 18.80 12 16419 1447 63471144
Pulmonary trichosporonosis 29.56 18.80 6 16425 56 63472535
Musculoskeletal stiffness 29.38 18.80 6 16425 184612 63287979
Toxic skin eruption 28.71 18.80 25 16406 12860 63459731
Confusional state 28.56 18.80 129 16302 236251 63236340
Eosinophilic pneumonia 28.18 18.80 13 16418 2198 63470393
Graft versus host disease 28.07 18.80 19 16412 6744 63465847
Acute myeloid leukaemia 28.03 18.80 28 16403 17119 63455472
Leukocytosis 27.90 18.80 34 16397 25901 63446690
Dysbiosis 27.77 18.80 10 16421 896 63471695
Staphylococcal infection 27.61 18.80 43 16388 41213 63431378
Hyperbilirubinaemia 27.35 18.80 23 16408 11291 63461300
Off label use 26.74 18.80 279 16152 674183 62798408
Pneumonia fungal 26.72 18.80 17 16414 5438 63467153
Product use issue 26.42 18.80 12 16419 220508 63252083
Weight increased 25.78 18.80 18 16413 260774 63211817
Hypoaesthesia 25.73 18.80 6 16425 168387 63304204
Disseminated intravascular coagulation 25.58 18.80 28 16403 19023 63453568
Acute graft versus host disease in skin 25.42 18.80 14 16417 3438 63469153
Hypersensitivity 25.42 18.80 23 16408 292662 63179929
Tumour lysis syndrome 25.36 18.80 20 16411 8970 63463621
Gait disturbance 25.22 18.80 8 16423 183170 63289421
Klebsiella bacteraemia 24.99 18.80 11 16420 1667 63470924
Tonsillitis bacterial 24.96 18.80 6 16425 128 63472463
Chemotherapeutic drug level increased 24.65 18.80 6 16425 135 63472456
Cholestasis 24.50 18.80 34 16397 29400 63443191
Aphasia 24.36 18.80 36 16395 32964 63439627
Neutropenic colitis 24.04 18.80 13 16418 3082 63469509
Candida infection 23.97 18.80 33 16398 28318 63444273
Pericarditis 23.79 18.80 3 16428 131576 63341015
Metabolic acidosis 23.50 18.80 42 16389 45027 63427564
Fall 23.47 18.80 41 16390 392293 63080298
Engraft failure 23.22 18.80 7 16424 359 63472232
Hyperoxaluria 23.10 18.80 6 16425 177 63472414
Stress cardiomyopathy 22.41 18.80 19 16412 9431 63463160
Neutrophilia 22.25 18.80 14 16417 4392 63468199
Eosinophilic pneumonia acute 22.17 18.80 7 16424 419 63472172
Cytomegalovirus viraemia 21.39 18.80 15 16416 5634 63466957
Pseudomembranous colitis 21.23 18.80 12 16419 3100 63469491
Muscle spasms 21.17 18.80 7 16424 156143 63316448
Blood bilirubin increased 21.17 18.80 36 16395 37104 63435487
Venoocclusive liver disease 21.06 18.80 14 16417 4821 63467770
Altered state of consciousness 20.78 18.80 29 16402 25201 63447390
Asthma 20.60 18.80 4 16427 127557 63345034
Thrombotic microangiopathy 20.58 18.80 19 16412 10542 63462049
Meningitis bacterial 20.48 18.80 9 16422 1358 63471233
Seizure 20.41 18.80 78 16353 132556 63340035
Ileus 20.39 18.80 22 16409 14703 63457888
Pulmonary haemorrhage 20.31 18.80 16 16415 7165 63465426
Enterococcal sepsis 20.17 18.80 9 16422 1409 63471182
Respiratory alkalosis 20.02 18.80 11 16420 2690 63469901
Pleural effusion 19.76 18.80 61 16370 93149 63379442
Small intestinal obstruction 19.66 18.80 24 16407 18313 63454278
Lower respiratory tract infection 19.65 18.80 5 16426 132302 63340289
Laryngeal inflammation 19.57 18.80 5 16426 138 63472453
Pain in extremity 19.49 18.80 35 16396 331451 63141140
Angiokeratoma 19.33 18.80 5 16426 145 63472446
Electrocardiogram T wave alternans 19.28 18.80 4 16427 42 63472549
Delirium 18.95 18.80 41 16390 50500 63422091

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Encephalopathy 248.14 16.07 191 21117 35128 34900495
Acute kidney injury 247.87 16.07 561 20747 304427 34631196
Neurotoxicity 192.78 16.07 126 21182 17884 34917739
Cytokine release syndrome 178.97 16.07 132 21176 22745 34912878
Febrile neutropenia 172.39 16.07 303 21005 136546 34799077
Drug reaction with eosinophilia and systemic symptoms 163.83 16.07 146 21162 32866 34902757
Septic shock 131.68 16.07 189 21119 71645 34863978
Respiratory failure 102.67 16.07 213 21095 108359 34827264
Multiple organ dysfunction syndrome 102.03 16.07 174 21134 76392 34859231
Pyrexia 89.49 16.07 420 20888 332593 34603030
Fatigue 87.03 16.07 60 21248 370593 34565030
Hypoxia 78.40 16.07 129 21179 54966 34880657
Immune effector cell-associated neurotoxicity syndrome 77.18 16.07 40 21268 3673 34931950
Renal tubular necrosis 77.04 16.07 69 21239 15611 34920012
Pathogen resistance 77.01 16.07 56 21252 9426 34926197
Clostridium difficile colitis 74.88 16.07 68 21240 15662 34919961
Acute generalised exanthematous pustulosis 73.91 16.07 48 21260 6728 34928895
Sepsis 73.73 16.07 246 21062 166315 34769308
Mental status changes 69.40 16.07 100 21208 37983 34897640
Myoclonus 68.81 16.07 63 21245 14662 34920961
Tubulointerstitial nephritis 68.66 16.07 74 21234 20950 34914673
Neutrophil count decreased 66.52 16.07 115 21193 50989 34884634
Dizziness 61.79 16.07 28 21280 218493 34717130
Methaemoglobinaemia 56.13 16.07 32 21276 3549 34932074
Product dose omission issue 54.68 16.07 5 21303 119706 34815917
Enterococcal infection 53.91 16.07 45 21263 9261 34926362
Death 49.29 16.07 106 21202 397943 34537680
Neutropenia 48.85 16.07 207 21101 156571 34779052
Bacteraemia 46.95 16.07 59 21249 19658 34915965
Disseminated intravascular coagulation 46.80 16.07 62 21246 21754 34913869
Pseudomonas infection 46.54 16.07 47 21261 12335 34923288
Bronchopulmonary aspergillosis 43.36 16.07 49 21259 14610 34921013
Meningitis candida 43.16 16.07 10 21298 71 34935552
Brain herniation 42.75 16.07 28 21280 3980 34931643
Status epilepticus 42.23 16.07 45 21263 12569 34923054
Haemodialysis 41.49 16.07 41 21267 10485 34925138
Immune thrombocytopenia 40.51 16.07 38 21270 9114 34926509
Myocardial infarction 40.10 16.07 12 21296 121073 34814550
Septic embolus 39.48 16.07 18 21290 1247 34934376
Nephropathy toxic 38.81 16.07 43 21265 12545 34923078
Aspergillus infection 38.03 16.07 42 21266 12212 34923411
Platelet count decreased 37.98 16.07 159 21149 119558 34816065
Arthralgia 37.84 16.07 29 21279 170012 34765611
Drug resistance 37.24 16.07 61 21247 25866 34909757
Acute respiratory distress syndrome 37.17 16.07 61 21247 25908 34909715
Fall 36.47 16.07 42 21266 202843 34732780
Botulism 35.74 16.07 10 21298 161 34935462
Thrombocytopenia 34.61 16.07 187 21121 156060 34779563
Confusional state 34.31 16.07 176 21132 143984 34791639
Blood culture positive 33.82 16.07 26 21282 4757 34930866
White blood cell count decreased 33.63 16.07 131 21177 95314 34840309
Aspartate aminotransferase increased 33.41 16.07 104 21204 67679 34867944
Depression 33.29 16.07 9 21299 97089 34838534
Glomerulosclerosis 32.95 16.07 14 21294 819 34934804
Systemic candida 32.53 16.07 23 21285 3703 34931920
Clostridium difficile infection 32.06 16.07 48 21260 18850 34916773
Pain 32.02 16.07 47 21261 204628 34730995
Antibiotic level above therapeutic 31.95 16.07 10 21298 241 34935382
Drug ineffective for unapproved indication 31.66 16.07 54 21254 23661 34911962
Cholestasis 31.64 16.07 58 21250 26890 34908733
Eosinophilia 30.23 16.07 56 21252 26166 34909457
Insomnia 29.81 16.07 13 21295 103894 34831729
Toxic encephalopathy 29.61 16.07 25 21283 5224 34930399
Haemophagocytic lymphohistiocytosis 29.58 16.07 38 21270 12935 34922688
Klebsiella infection 29.56 16.07 31 21277 8500 34927123
Cytomegalovirus viraemia 29.39 16.07 29 21279 7401 34928222
Uraemic encephalopathy 29.09 16.07 10 21298 326 34935297
Weight decreased 29.04 16.07 39 21269 176262 34759361
Mucormycosis 28.88 16.07 26 21282 5916 34929707
Cytomegalovirus enterocolitis 27.47 16.07 13 21295 981 34934642
Candida infection 27.24 16.07 43 21265 17672 34917951
Toxic epidermal necrolysis 27.21 16.07 48 21260 21598 34914025
Gait disturbance 27.17 16.07 9 21299 85131 34850492
Burkholderia test positive 27.11 16.07 13 21295 1010 34934613
Blood pressure increased 26.94 16.07 10 21298 88092 34847531
Drug ineffective 25.96 16.07 406 20902 456345 34479278
Dyspnoea 25.92 16.07 130 21178 376652 34558971
Enterocolitis 25.75 16.07 28 21280 7998 34927625
Metabolic encephalopathy 25.36 16.07 21 21287 4271 34931352
Cytokine storm 25.03 16.07 11 21297 699 34934924
Anxiety 24.71 16.07 15 21293 99413 34836210
Off label use 24.62 16.07 375 20933 419149 34516474
Alanine aminotransferase increased 24.57 16.07 106 21202 80709 34854914
Disseminated mucormycosis 24.47 16.07 10 21298 530 34935093
Headache 24.26 16.07 54 21254 200581 34735042
Pleural effusion 24.06 16.07 106 21202 81440 34854183
Respiratory distress 23.71 16.07 61 21247 35604 34900019
Joint swelling 23.69 16.07 4 21304 59886 34875737
Feeling abnormal 23.36 16.07 5 21303 63230 34872393
Bacterial toxaemia 23.32 16.07 7 21301 146 34935477
Malaise 23.31 16.07 49 21259 185776 34749847
Asthenia 22.89 16.07 75 21233 245176 34690447
Peripheral swelling 22.88 16.07 9 21299 76532 34859091
Inappropriate schedule of product administration 22.86 16.07 5 21303 62291 34873332
Acute respiratory failure 22.77 16.07 55 21253 30873 34904750
Acute myeloid leukaemia recurrent 22.75 16.07 15 21293 2155 34933468
Choluria 22.64 16.07 7 21301 162 34935461
Rash morbilliform 22.31 16.07 17 21291 3070 34932553
Transaminases increased 22.27 16.07 50 21258 26773 34908850
Delirium 22.13 16.07 68 21240 43923 34891700
Renal failure 21.68 16.07 145 21163 130412 34805211
Trichosporon infection 21.52 16.07 10 21298 724 34934899
Blood creatinine increased 21.21 16.07 114 21194 94862 34840761
Hypersensitivity vasculitis 21.14 16.07 17 21291 3318 34932305
Acute myeloid leukaemia 21.04 16.07 39 21269 18231 34917392
Drug-induced liver injury 20.94 16.07 51 21257 28781 34906842
Fungal infection 20.89 16.07 36 21272 15899 34919724
Leukoerythroblastosis 20.43 16.07 5 21303 46 34935577
Cerebral aspergillosis 20.33 16.07 12 21296 1420 34934203
Kidney fibrosis 20.02 16.07 14 21294 2214 34933409
Corynebacterium infection 19.84 16.07 9 21299 616 34935007
Drug intolerance 19.53 16.07 6 21302 59564 34876059
Systemic mycosis 19.29 16.07 12 21296 1561 34934062
Aphasia 18.95 16.07 41 21267 21413 34914210
Musculoskeletal stiffness 18.72 16.07 3 21305 46677 34888946
Lactobacillus infection 18.56 16.07 7 21301 299 34935324
Pneumonia bacterial 18.50 16.07 29 21279 11843 34923780
Vanishing bile duct syndrome 18.42 16.07 10 21298 1008 34934615
Agranulocytosis 18.22 16.07 43 21265 23778 34911845
Acute lymphocytic leukaemia recurrent 18.21 16.07 15 21293 3029 34932594
Nasopharyngitis 18.17 16.07 10 21298 69958 34865665
Procalcitonin increased 18.11 16.07 12 21296 1739 34933884
Disseminated cryptococcosis 18.08 16.07 11 21297 1375 34934248
Sputum culture positive 17.88 16.07 12 21296 1776 34933847
Hypotension 17.86 16.07 210 21098 221439 34714184
Flavobacterium infection 17.84 16.07 5 21303 81 34935542
Pancytopenia 17.83 16.07 109 21199 95048 34840575
Differentiation syndrome 17.71 16.07 11 21297 1427 34934196
Organising pneumonia 17.70 16.07 20 21288 5959 34929664
Muscle spasms 17.69 16.07 12 21296 74989 34860634
Pneumonia 17.48 16.07 314 20994 362313 34573310
Enterococcal bacteraemia 17.24 16.07 12 21296 1885 34933738
Pulmonary haemorrhage 17.23 16.07 26 21282 10278 34925345
Unresponsive to stimuli 17.15 16.07 46 21262 27523 34908100
Eye infection fungal 17.09 16.07 7 21301 373 34935250
Pain in extremity 17.02 16.07 32 21276 126481 34809142
Retinal ischaemia 16.97 16.07 7 21301 380 34935243
Dialysis 16.95 16.07 27 21281 11181 34924442
Memory impairment 16.89 16.07 3 21305 43315 34892308
Enterobacter infection 16.72 16.07 13 21295 2417 34933206
Tumour lysis syndrome 16.69 16.07 34 21274 17025 34918598
Staphylococcal sepsis 16.69 16.07 25 21283 9819 34925804
Adenoviral haemorrhagic cystitis 16.51 16.07 7 21301 407 34935216
Drug eruption 16.41 16.07 37 21271 19861 34915762
Hepatosplenic candidiasis 16.29 16.07 6 21302 240 34935383
Nausea 16.27 16.07 131 21177 339777 34595846

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Encephalopathy 641.01 15.98 390 35219 67007 79641772
Acute kidney injury 540.85 15.98 887 34722 518517 79190262
Neurotoxicity 415.02 15.98 228 35381 32290 79676489
Febrile neutropenia 393.00 15.98 499 35110 230500 79478279
Drug reaction with eosinophilia and systemic symptoms 351.41 15.98 264 35345 63980 79644799
Cytokine release syndrome 336.01 15.98 206 35403 35792 79672987
Septic shock 238.65 15.98 284 35325 122517 79586262
Multiple organ dysfunction syndrome 213.98 15.98 266 35343 119980 79588799
Status epilepticus 210.19 15.98 134 35475 24907 79683872
Myoclonus 190.90 15.98 131 35478 27529 79681250
Pyrexia 185.39 15.98 693 34916 678016 79030763
Sepsis 182.95 15.98 384 35225 269044 79439735
Respiratory failure 180.36 15.98 304 35305 180607 79528172
Mental status changes 173.34 15.98 180 35429 66779 79642000
Thrombocytopenia 151.70 15.98 353 35256 264906 79443873
Immune effector cell-associated neurotoxicity syndrome 149.83 15.98 66 35543 5782 79702997
Acute generalised exanthematous pustulosis 146.45 15.98 93 35516 17161 79691618
Tubulointerstitial nephritis 145.09 15.98 127 35482 38108 79670671
Fatigue 144.97 15.98 122 35487 929605 78779174
Renal tubular necrosis 137.01 15.98 103 35506 24936 79683843
Pain 137.01 15.98 72 35537 703730 79005049
Hypoxia 129.75 15.98 193 35416 103050 79605729
Arthralgia 127.71 15.98 48 35561 571755 79137024
Clostridium difficile colitis 126.05 15.98 109 35500 32174 79676605
Neutrophil count decreased 124.36 15.98 180 35429 93779 79615000
Neutropenia 120.98 15.98 341 35268 287369 79421410
Pathogen resistance 118.48 15.98 76 35533 14266 79694513
Dizziness 109.73 15.98 49 35560 526392 79182387
Platelet count decreased 106.76 15.98 255 35354 194409 79514370
Joint swelling 104.70 15.98 6 35603 288640 79420139
Drug resistance 101.24 15.98 109 35500 42104 79666675
Toxic encephalopathy 100.43 15.98 63 35546 11377 79697402
Bacteraemia 89.90 15.98 91 35518 32733 79676046
Headache 88.60 15.98 97 35512 653675 79055104
Enterococcal infection 86.96 15.98 65 35544 15595 79693184
Klebsiella infection 84.52 15.98 64 35545 15656 79693123
Drug intolerance 81.01 15.98 11 35598 264108 79444671
Product dose omission issue 79.11 15.98 9 35600 247528 79461251
Acute respiratory distress syndrome 77.50 15.98 97 35512 43970 79664809
Malaise 73.99 15.98 66 35543 489803 79218976
Rheumatoid arthritis 73.58 15.98 5 35604 208465 79500314
Nasopharyngitis 72.36 15.98 13 35596 253868 79454911
Pneumonia 71.77 15.98 522 35087 659724 79049055
Bronchopulmonary aspergillosis 70.74 15.98 67 35542 22227 79686552
Nephropathy toxic 69.87 15.98 64 35545 20355 79688424
Pseudomonas infection 68.59 15.98 64 35545 20839 79687940
Disseminated intravascular coagulation 68.04 15.98 82 35527 35760 79673019
Alopecia 67.79 15.98 11 35598 231344 79477435
Aspartate aminotransferase increased 66.86 15.98 173 35436 138468 79570311
Peripheral swelling 66.46 15.98 19 35590 269598 79439181
Eosinophilia 66.07 15.98 91 35518 45254 79663525
White blood cell count decreased 64.70 15.98 208 35401 188080 79520699
Clostridium difficile infection 64.22 15.98 87 35522 42598 79666181
Pancytopenia 63.33 15.98 190 35419 165555 79543224
Arthropathy 63.23 15.98 4 35605 177107 79531672
Abdominal discomfort 63.04 15.98 17 35592 250710 79458069
Mucormycosis 62.92 15.98 42 35567 8427 79700352
Fall 60.98 15.98 77 35532 487552 79221227
Therapeutic product effect decreased 60.66 15.98 3 35606 163860 79544919
Drug ineffective for unapproved indication 60.37 15.98 93 35516 51145 79657634
Renal failure 59.34 15.98 211 35398 200757 79508022
Blood creatinine increased 57.59 15.98 176 35433 154881 79553898
Methaemoglobinaemia 57.49 15.98 34 35575 5523 79703256
Weight decreased 57.10 15.98 45 35564 355153 79353626
Trichosporon infection 56.34 15.98 20 35589 988 79707791
Brain herniation 55.41 15.98 37 35572 7426 79701353
Confusional state 55.14 15.98 284 35325 317713 79391066
Cholestasis 55.07 15.98 90 35519 52019 79656760
Antibiotic level above therapeutic 54.29 15.98 18 35591 722 79708057
Metabolic encephalopathy 53.10 15.98 39 35570 9108 79699671
Haemodialysis 52.75 15.98 52 35557 18116 79690663
Toxic epidermal necrolysis 51.23 15.98 80 35529 44501 79664278
Acute respiratory failure 50.10 15.98 93 35516 59448 79649331
Shock 49.84 15.98 78 35531 43470 79665309
Musculoskeletal stiffness 49.76 15.98 9 35600 174999 79533780
Agranulocytosis 49.26 15.98 79 35530 44951 79663828
Septic embolus 48.86 15.98 22 35587 2029 79706750
Gait disturbance 48.64 15.98 16 35593 207490 79501289
Off label use 48.33 15.98 617 34992 906598 78802181
Alanine aminotransferase increased 48.24 15.98 171 35438 162399 79546380
Haemophagocytic lymphohistiocytosis 48.21 15.98 54 35555 21783 79686996
Hypotension 48.21 15.98 349 35260 439968 79268811
Fungaemia 47.26 15.98 28 35581 4563 79704216
Pleural effusion 46.76 15.98 157 35452 145105 79563674
Respiratory distress 46.45 15.98 89 35520 58250 79650529
Pain in extremity 46.13 15.98 57 35552 364481 79344298
Dyspnoea 45.89 15.98 212 35397 856813 78851966
Differentiation syndrome 44.51 15.98 22 35587 2502 79706277
Neutropenic colitis 44.08 15.98 29 35580 5678 79703101
Depression 43.79 15.98 21 35588 216769 79492010
Cytomegalovirus viraemia 43.50 15.98 40 35569 12781 79695998
Nausea 43.25 15.98 251 35358 956945 78751834
Candida infection 43.11 15.98 68 35541 38146 79670633
Cholestatic liver injury 42.84 15.98 27 35582 4914 79703865
Insomnia 42.05 15.98 29 35580 245141 79463638
Acute myeloid leukaemia 42.04 15.98 60 35549 30825 79677954
Blood pressure increased 41.90 15.98 21 35588 211339 79497440
Myocardial infarction 41.76 15.98 15 35594 184114 79524665
Weight increased 41.07 15.98 38 35571 277348 79431431
Tumour lysis syndrome 40.98 15.98 52 35557 23887 79684892
Meningitis candida 40.53 15.98 10 35599 134 79708645
Delirium 40.16 15.98 105 35504 84522 79624257
Hypoaesthesia 40.02 15.98 15 35594 179337 79529442
Systemic candida 39.85 15.98 29 35580 6677 79702102
Staphylococcal infection 39.32 15.98 83 35526 58212 79650567
Enterocolitis 39.30 15.98 40 35569 14472 79694307
Immune thrombocytopenia 39.25 15.98 44 35565 17761 79691018
Pulmonary haemorrhage 38.83 15.98 40 35569 14677 79694102
Blood bilirubin increased 38.68 15.98 89 35520 66143 79642636
Asthma 38.29 15.98 7 35602 135088 79573691
Aspergillus infection 38.28 15.98 45 35564 19116 79689663
Drug-induced liver injury 36.59 15.98 87 35522 66030 79642749
Renal impairment 36.20 15.98 153 35456 157630 79551149
Aphasia 35.62 15.98 70 35539 46662 79662117
Enterococcal bacteraemia 34.99 15.98 20 35589 3048 79705731
Arthritis 34.69 15.98 5 35604 114875 79593904
Discomfort 34.56 15.98 7 35602 125610 79583169
Feeling abnormal 34.39 15.98 14 35595 159185 79549594
Pneumonia fungal 34.25 15.98 33 35576 11177 79697602
Lower respiratory tract infection 33.93 15.98 8 35601 129212 79579567
Sinusitis 33.68 15.98 23 35586 195478 79513301
Muscle spasms 33.68 15.98 18 35591 174712 79534067
Swelling 32.89 15.98 29 35580 216682 79492097
Systemic lupus erythematosus 32.82 15.98 7 35602 121142 79587637
Mixed liver injury 32.47 15.98 27 35582 7551 79701228
Injection site pain 32.25 15.98 9 35600 129829 79578950
Drug level increased 32.19 15.98 61 35548 39590 79669189
Blood culture positive 31.96 15.98 28 35581 8401 79700378
Liver abscess 31.12 15.98 24 35585 6030 79702749
Pulmonary trichosporonosis 31.01 15.98 7 35602 62 79708717
Hepatic function abnormal 30.97 15.98 87 35522 73020 79635759
Cytomegalovirus enterocolitis 30.90 15.98 15 35594 1640 79707139
Rash morbilliform 30.78 15.98 24 35585 6126 79702653
Botulism 30.66 15.98 10 35599 381 79708398
Leukocytosis 30.62 15.98 63 35546 43392 79665387
Balance disorder 30.56 15.98 4 35605 98853 79609926
Anxiety 30.23 15.98 40 35569 248472 79460307
Rash maculo-papular 30.18 15.98 73 35536 56005 79652774
Paraesthesia 30.03 15.98 21 35588 176302 79532477
Leukopenia 29.90 15.98 117 35492 116396 79592383
Glomerulosclerosis 29.83 15.98 13 35596 1109 79707670
Cytomegalovirus test positive 29.32 15.98 23 35586 5924 79702855
Enterococcal sepsis 29.04 15.98 17 35592 2709 79706070
Uraemic encephalopathy 28.68 15.98 11 35598 676 79708103
Back pain 28.56 15.98 58 35551 304122 79404657
Pneumonia bacterial 28.46 15.98 39 35570 19292 79689487
Gastrooesophageal reflux disease 28.28 15.98 6 35603 104240 79604539
Contusion 27.69 15.98 16 35593 148760 79560019
Drug ineffective 27.14 15.98 652 34957 1080261 78628518
Engraftment syndrome 27.00 15.98 13 35596 1396 79707383
Blood cholesterol increased 26.83 15.98 3 35606 83717 79625062
Graft versus host disease 26.29 15.98 33 35576 14993 79693786
Dry mouth 26.18 15.98 4 35605 88015 79620764
Dyspepsia 26.13 15.98 8 35601 108679 79600100
Venoocclusive liver disease 25.79 15.98 29 35580 11742 79697037
Drug eruption 25.60 15.98 59 35550 43876 79664903
Chest pain 25.51 15.98 55 35554 282249 79426530
Asthenia 25.31 15.98 130 35479 511559 79197220
Cardiac arrest 25.26 15.98 147 35462 171949 79536830
Abdominal pain upper 25.25 15.98 38 35571 223781 79484998
Encephalitis Japanese B 25.24 15.98 6 35603 68 79708711
Unresponsive to stimuli 25.22 15.98 68 35541 55720 79653059
Bacterial toxaemia 25.04 15.98 7 35602 156 79708623
Procalcitonin increased 25.00 15.98 16 35593 2990 79705789
Nephritis allergic 24.56 15.98 10 35599 720 79708059
Activated partial thromboplastin time prolonged 24.50 15.98 31 35578 14197 79694582
Pericarditis 24.48 15.98 8 35601 104228 79604551
Disseminated mucormycosis 24.33 15.98 10 35599 738 79708041
Systemic mycosis 24.20 15.98 15 35594 2651 79706128
Loss of personal independence in daily activities 23.87 15.98 8 35601 102572 79606207
Meningitis bacterial 23.86 15.98 15 35594 2717 79706062
Memory impairment 23.84 15.98 10 35599 111724 79597055
Disseminated cryptococcosis 23.76 15.98 13 35596 1821 79706958
Osteoarthritis 23.73 15.98 5 35604 87304 79621475
Blood urea increased 23.61 15.98 61 35548 48729 79660050
Small intestinal obstruction 23.44 15.98 43 35566 27229 79681550
Transaminases increased 23.32 15.98 63 35546 51680 79657099
Enterobacter infection 23.26 15.98 18 35591 4544 79704235
Burkholderia test positive 23.12 15.98 9 35600 576 79708203
Hypersensitivity 22.95 15.98 52 35557 262187 79446592
Intentional product misuse 22.89 15.98 7 35602 95158 79613621
Serum ferritin increased 22.85 15.98 25 35584 9822 79698957
Hyperbilirubinaemia 22.79 15.98 40 35569 24478 79684301
Pseudomembranous colitis 22.72 15.98 19 35590 5355 79703424
Acute lymphocytic leukaemia recurrent 22.70 15.98 18 35591 4706 79704073
Inappropriate schedule of product administration 22.64 15.98 16 35593 133612 79575167
Device related infection 22.17 15.98 48 35561 34246 79674533
Lung infiltration 22.10 15.98 38 35571 22874 79685905
Clostridial infection 21.70 15.98 19 35590 5695 79703084
Corynebacterium infection 21.64 15.98 11 35598 1327 79707452
Chest discomfort 21.51 15.98 18 35591 138026 79570753
Vanishing bile duct syndrome 21.38 15.98 12 35597 1766 79707013
Systemic inflammatory response syndrome 21.38 15.98 26 35583 11439 79697340
Escherichia bacteraemia 21.35 15.98 20 35589 6542 79702237
Cerebral aspergillosis 21.27 15.98 12 35597 1784 79706995
Cytokine storm 21.11 15.98 10 35599 1036 79707743
Acidosis 20.69 15.98 34 35575 19728 79689051
Eosinophilic pneumonia acute 20.65 15.98 10 35599 1088 79707691
COVID-19 pneumonia 20.53 15.98 42 35567 28807 79679972
Device related sepsis 20.26 15.98 19 35590 6221 79702558
Tonsillitis bacterial 20.16 15.98 6 35603 168 79708611
Klebsiella bacteraemia 20.15 15.98 14 35595 2996 79705783
Product use in unapproved indication 20.05 15.98 185 35424 250174 79458605
Pulseless electrical activity 19.99 15.98 28 35581 14132 79694647
Respiratory alkalosis 19.81 15.98 16 35593 4295 79704484
Heparin-induced thrombocytopenia 19.77 15.98 23 35586 9659 79699120
Mediastinitis 19.73 15.98 9 35600 855 79707924
Staphylococcus test positive 19.65 15.98 19 35590 6462 79702317
Dialysis 19.65 15.98 32 35577 18430 79690349
Chemotherapeutic drug level increased 19.64 15.98 7 35602 350 79708429
Stenotrophomonas infection 19.48 15.98 15 35594 3758 79705021
Vomiting 19.38 15.98 197 35412 665631 79043148
Hypervolaemia 19.26 15.98 52 35557 42638 79666141
Therapeutic product effect incomplete 19.12 15.98 21 35588 141624 79567155
Organising pneumonia 19.10 15.98 24 35585 10915 79697864
Laryngeal inflammation 19.02 15.98 6 35603 205 79708574
Product contamination microbial 18.95 15.98 9 35600 937 79707842
Choluria 18.76 15.98 7 35602 399 79708380
Vertigo 18.69 15.98 4 35605 69078 79639701
Vascular device infection 18.67 15.98 23 35586 10253 79698526
Tachypnoea 18.62 15.98 43 35566 32020 79676759
Flavobacterium infection 18.49 15.98 5 35604 98 79708681
Coagulopathy 18.45 15.98 46 35563 35960 79672819
Injection site erythema 18.36 15.98 6 35603 78191 79630588
Hypertensive heart disease 18.05 15.98 15 35594 4191 79704588
Blastomycosis 18.05 15.98 8 35601 711 79708068
Palpitations 17.96 15.98 18 35591 126592 79582187
Adverse drug reaction 17.64 15.98 4 35605 66388 79642391
Cerebral haemorrhage 17.37 15.98 61 35548 57612 79651167
Pulmonary mucormycosis 17.18 15.98 9 35600 1156 79707623
Pneumonitis 17.16 15.98 63 35546 60797 79647982
Flushing 17.14 15.98 9 35600 88259 79620520
Blood lactate dehydrogenase increased 16.96 15.98 47 35562 39123 79669656
Eye infection fungal 16.96 15.98 7 35602 522 79708257
Impaired healing 16.93 15.98 9 35600 87646 79621133
Anaemia 16.60 15.98 285 35324 444730 79264049
Acute myeloid leukaemia recurrent 16.49 15.98 13 35596 3370 79705409
Product use issue 16.47 15.98 44 35565 209778 79499001
Liver disorder 16.42 15.98 70 35539 72347 79636432
Hypoalbuminaemia 16.35 15.98 32 35577 21265 79687514
Vision blurred 16.26 15.98 14 35595 105884 79602895
Hepatosplenic candidiasis 16.25 15.98 7 35602 581 79708198
Hypercapnia 16.23 15.98 20 35589 8915 79699864
Lymphatic disorder 16.21 15.98 6 35603 334 79708445
Posterior reversible encephalopathy syndrome 16.10 15.98 36 35573 26245 79682534
Arteritis coronary 16.05 15.98 4 35605 56 79708723
Rectal haemorrhage 16.00 15.98 7 35602 76293 79632486
Kidney fibrosis 15.99 15.98 13 35596 3522 79705257

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC J01DE01 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIBACTERIALS FOR SYSTEMIC USE
OTHER BETA-LACTAM ANTIBACTERIALS
Fourth-generation cephalosporins
ATC J01RA06 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIBACTERIALS FOR SYSTEMIC USE
COMBINATIONS OF ANTIBACTERIALS
Combinations of antibacterials
FDA CS M0003827 Cephalosporins
FDA EPC N0000175488 Cephalosporin Antibacterial
MeSH PA D000900 Anti-Bacterial Agents
MeSH PA D000890 Anti-Infective Agents
CHEBI has role CHEBI:36047 antibacterial drugs

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Infection due to Pseudomonas aeruginosa indication 11218009
Pneumonia due to Streptococcus indication 34020007
Pneumonia due to Pseudomonas indication 41381004
Bacterial pneumonia indication 53084003 DOID:874
Klebsiella cystitis indication 60867007
Infectious disease of abdomen indication 128070006
Bacterial infection due to Klebsiella pneumoniae indication 186435004
Bacterial peritonitis indication 197171003
Pneumococcal pneumonia indication 233607000
Escherichia coli urinary tract infection indication 301011002
Proteus urinary tract infection indication 301012009
Streptococcus pyogenes infection indication 302809008
Bacterial urinary infection indication 312124009
Infection due to Staphylococcus aureus indication 406602003
Urinary tract infection caused by Klebsiella indication 369001000119100
Complicated Proteus UTI indication
E. Coli Pyelonephritis indication
Complicated Urinary Tract Infections indication
Complicated Bacteroides Peritonitis indication
Complicated Streptococcus Peritonitis indication
Klebsiella Pyelonephritis indication
Complicated E. Coli Peritonitis indication
Enterobacter Pneumonia indication
Complicated Klebsiella Peritonitis indication
Proteus Pyelonephritis indication
Myoclonus contraindication 17450006
Colitis contraindication 64226004 DOID:0060180
Blood coagulation disorder contraindication 64779008 DOID:1247
Factor II deficiency contraindication 73975000
Disorder of brain contraindication 81308009 DOID:936
Seizure disorder contraindication 128613002
Impaired renal function disorder contraindication 197663003
Pseudomembranous enterocolitis contraindication 397683000




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 2.32 acidic
pKa2 13.31 acidic
pKa3 3.1 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Bacterial penicillin-binding protein Enzyme INHIBITOR CHEMBL CHEMBL

External reference:

IDSource
4024049 VUID
N0000022054 NUI
D01157 KEGG_DRUG
123171-59-5 SECONDARY_CAS_RN
20481 RXNORM
C0055003 UMLSCUI
CHEBI:478164 CHEBI
9WT PDB_CHEM_ID
CHEMBL186 ChEMBL_ID
CHEMBL1200962 ChEMBL_ID
D000077723 MESH_DESCRIPTOR_UI
DB01413 DRUGBANK_ID
10772 IUPHAR_LIGAND_ID
6092 INN_ID
807PW4VQE3 UNII
5479537 PUBCHEM_CID
116681 MMSL
4373 MMSL
d03882 MMSL
370370003 SNOMEDCT_US
370371004 SNOMEDCT_US
96048006 SNOMEDCT_US
4020908 VANDF
4024049 VANDF
004974 NDDF
004975 NDDF

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
CEFEPIME HYDROCHLORIDE AND DEXTROSE HUMAN PRESCRIPTION DRUG LABEL 1 0264-3193 INJECTION, SOLUTION 1 g INTRAVENOUS NDA 30 sections
CEFEPIME HYDROCHLORIDE AND DEXTROSE HUMAN PRESCRIPTION DRUG LABEL 1 0264-3193 INJECTION, SOLUTION 1 g INTRAVENOUS NDA 30 sections
CEFEPIME HYDROCHLORIDE AND DEXTROSE HUMAN PRESCRIPTION DRUG LABEL 1 0264-3195 INJECTION, SOLUTION 2 g INTRAVENOUS NDA 30 sections
CEFEPIME HYDROCHLORIDE AND DEXTROSE HUMAN PRESCRIPTION DRUG LABEL 1 0264-3195 INJECTION, SOLUTION 2 g INTRAVENOUS NDA 30 sections
Cefepime HUMAN PRESCRIPTION DRUG LABEL 1 0338-1301 INJECTION, SOLUTION 1 g INTRAVENOUS NDA 28 sections
Cefepime HUMAN PRESCRIPTION DRUG LABEL 1 0338-1301 INJECTION, SOLUTION 1 g INTRAVENOUS NDA 28 sections
Cefepime HUMAN PRESCRIPTION DRUG LABEL 1 0338-1301 INJECTION, SOLUTION 1 g INTRAVENOUS NDA 28 sections
Cefepime HUMAN PRESCRIPTION DRUG LABEL 1 0338-1301 INJECTION, SOLUTION 1 g INTRAVENOUS NDA 28 sections
Cefepime HUMAN PRESCRIPTION DRUG LABEL 1 0409-9566 INJECTION, POWDER, FOR SOLUTION 1 g INTRAVENOUS ANDA 27 sections
Cefepime HUMAN PRESCRIPTION DRUG LABEL 1 0409-9566 INJECTION, POWDER, FOR SOLUTION 1 g INTRAVENOUS ANDA 27 sections
Cefepime HUMAN PRESCRIPTION DRUG LABEL 1 0409-9735 INJECTION, POWDER, FOR SOLUTION 2 g INTRAVENOUS ANDA 27 sections
Cefepime HUMAN PRESCRIPTION DRUG LABEL 1 0409-9735 INJECTION, POWDER, FOR SOLUTION 2 g INTRAVENOUS ANDA 27 sections
Cefepime Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0781-3222 INJECTION, POWDER, FOR SOLUTION 1 g INTRAVENOUS ANDA 27 sections
Cefepime Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0781-3223 INJECTION, POWDER, FOR SOLUTION 2 g INTRAVENOUS ANDA 27 sections
cefepime HUMAN PRESCRIPTION DRUG LABEL 1 25021-121 INJECTION, POWDER, FOR SOLUTION 1 g INTRAVENOUS ANDA 29 sections
cefepime HUMAN PRESCRIPTION DRUG LABEL 1 25021-121 INJECTION, POWDER, FOR SOLUTION 1 g INTRAVENOUS ANDA 29 sections
cefepime HUMAN PRESCRIPTION DRUG LABEL 1 25021-121 INJECTION, POWDER, FOR SOLUTION 1 g INTRAVENOUS ANDA 29 sections
cefepime HUMAN PRESCRIPTION DRUG LABEL 1 25021-121 INJECTION, POWDER, FOR SOLUTION 1 g INTRAVENOUS ANDA 29 sections
cefepime HUMAN PRESCRIPTION DRUG LABEL 1 25021-122 INJECTION, POWDER, FOR SOLUTION 2 g INTRAVENOUS ANDA 29 sections
cefepime HUMAN PRESCRIPTION DRUG LABEL 1 25021-122 INJECTION, POWDER, FOR SOLUTION 2 g INTRAVENOUS ANDA 29 sections
cefepime HUMAN PRESCRIPTION DRUG LABEL 1 25021-122 INJECTION, POWDER, FOR SOLUTION 2 g INTRAVENOUS ANDA 29 sections
cefepime HUMAN PRESCRIPTION DRUG LABEL 1 25021-122 INJECTION, POWDER, FOR SOLUTION 2 g INTRAVENOUS ANDA 29 sections
Cefepime HUMAN PRESCRIPTION DRUG LABEL 1 44567-130 INJECTION, POWDER, FOR SOLUTION 1 g INTRAVENOUS ANDA 26 sections
Cefepime HUMAN PRESCRIPTION DRUG LABEL 1 44567-131 INJECTION, POWDER, FOR SOLUTION 2 g INTRAVENOUS ANDA 26 sections
Cefepime HUMAN PRESCRIPTION DRUG LABEL 1 44567-240 INJECTION, POWDER, FOR SOLUTION 1 g INTRAVENOUS ANDA 26 sections
Cefepime HUMAN PRESCRIPTION DRUG LABEL 1 44567-241 INJECTION, POWDER, FOR SOLUTION 2 g INTRAVENOUS ANDA 26 sections
Cefepime HUMAN PRESCRIPTION DRUG LABEL 1 60505-6144 INJECTION, POWDER, FOR SOLUTION 1 g INTRAVENOUS ANDA 28 sections
Cefepime HUMAN PRESCRIPTION DRUG LABEL 1 60505-6144 INJECTION, POWDER, FOR SOLUTION 1 g INTRAVENOUS ANDA 28 sections
Cefepime HUMAN PRESCRIPTION DRUG LABEL 1 60505-6144 INJECTION, POWDER, FOR SOLUTION 1 g INTRAVENOUS ANDA 28 sections
Cefepime HUMAN PRESCRIPTION DRUG LABEL 1 60505-6145 INJECTION, POWDER, FOR SOLUTION 2 g INTRAVENOUS ANDA 28 sections