Stem definition | Drug id | CAS RN |
---|---|---|
antibiotics, cefalosporanic acid derivatives | 535 | 88040-23-7 |
Dose | Unit | Route |
---|---|---|
4 | g | P |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 3 | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 85 % | Benet LZ, Broccatelli F, Oprea TI |
BA (Bioavailability) | 99 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Vd (Volume of distribution) | 0.28 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 2.20 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.78 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 1.90 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
Jan. 18, 1996 | FDA | HOSPIRA INC |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Encephalopathy | 462.19 | 18.80 | 217 | 16214 | 38403 | 63434188 |
Acute kidney injury | 337.13 | 18.80 | 376 | 16055 | 263039 | 63209552 |
Febrile neutropenia | 294.20 | 18.80 | 244 | 16187 | 118205 | 63354386 |
Neurotoxicity | 239.25 | 18.80 | 107 | 16324 | 16883 | 63455708 |
Drug reaction with eosinophilia and systemic symptoms | 219.15 | 18.80 | 126 | 16305 | 33710 | 63438881 |
Status epilepticus | 208.31 | 18.80 | 94 | 16337 | 15139 | 63457452 |
Multiple organ dysfunction syndrome | 172.95 | 18.80 | 132 | 16299 | 56620 | 63415971 |
Cytokine release syndrome | 160.51 | 18.80 | 77 | 16354 | 14237 | 63458354 |
Myoclonus | 144.22 | 18.80 | 74 | 16357 | 15794 | 63456797 |
Sepsis | 143.44 | 18.80 | 187 | 16244 | 152936 | 63319655 |
Acute generalised exanthematous pustulosis | 140.74 | 18.80 | 65 | 16366 | 11034 | 63461557 |
Pyrexia | 137.61 | 18.80 | 345 | 16086 | 470133 | 63002458 |
Septic shock | 132.32 | 18.80 | 121 | 16310 | 66508 | 63406083 |
Thrombocytopenia | 131.41 | 18.80 | 178 | 16253 | 150979 | 63321612 |
Mental status changes | 107.37 | 18.80 | 86 | 16345 | 39513 | 63433078 |
Pain | 103.18 | 18.80 | 32 | 16399 | 740596 | 62731995 |
Respiratory failure | 100.94 | 18.80 | 128 | 16303 | 101730 | 63370861 |
Toxic encephalopathy | 91.19 | 18.80 | 41 | 16390 | 6538 | 63466053 |
Tubulointerstitial nephritis | 87.67 | 18.80 | 58 | 16373 | 19845 | 63452746 |
Neutropenia | 85.10 | 18.80 | 158 | 16273 | 174847 | 63297744 |
Arthralgia | 80.34 | 18.80 | 24 | 16407 | 569686 | 62902905 |
Clostridium difficile colitis | 76.51 | 18.80 | 54 | 16377 | 20515 | 63452076 |
Immune effector cell-associated neurotoxicity syndrome | 73.07 | 18.80 | 26 | 16405 | 2251 | 63470340 |
Fatigue | 72.71 | 18.80 | 74 | 16357 | 887954 | 62584637 |
Klebsiella infection | 69.40 | 18.80 | 37 | 16394 | 8529 | 63464062 |
Neutrophil count decreased | 67.44 | 18.80 | 78 | 16353 | 56328 | 63416263 |
Pneumonia | 66.17 | 18.80 | 263 | 16168 | 456504 | 63016087 |
Shock | 65.81 | 18.80 | 52 | 16379 | 23411 | 63449180 |
Abdominal discomfort | 64.18 | 18.80 | 5 | 16426 | 320880 | 63151711 |
Platelet count decreased | 62.98 | 18.80 | 110 | 16321 | 116012 | 63356579 |
Alopecia | 62.88 | 18.80 | 7 | 16424 | 337529 | 63135062 |
Hypoxia | 62.15 | 18.80 | 77 | 16354 | 59715 | 63412876 |
Drug resistance | 60.43 | 18.80 | 49 | 16382 | 22884 | 63449707 |
Bacteraemia | 58.69 | 18.80 | 43 | 16388 | 17305 | 63455286 |
Pathogen resistance | 58.59 | 18.80 | 30 | 16401 | 6368 | 63466223 |
Renal tubular necrosis | 55.69 | 18.80 | 36 | 16395 | 11842 | 63460749 |
Mixed liver injury | 54.67 | 18.80 | 26 | 16405 | 4709 | 63467882 |
Nasopharyngitis | 53.66 | 18.80 | 3 | 16428 | 254254 | 63218337 |
Drug intolerance | 53.63 | 18.80 | 8 | 16423 | 308653 | 63163938 |
Acute respiratory distress syndrome | 53.15 | 18.80 | 46 | 16385 | 23488 | 63449103 |
Pancytopenia | 50.19 | 18.80 | 90 | 16341 | 96843 | 63375748 |
Headache | 49.20 | 18.80 | 55 | 16376 | 633186 | 62839405 |
Rheumatoid arthritis | 47.92 | 18.80 | 5 | 16426 | 253814 | 63218777 |
Fungaemia | 46.60 | 18.80 | 19 | 16412 | 2384 | 63470207 |
Aspartate aminotransferase increased | 45.69 | 18.80 | 83 | 16348 | 90194 | 63382397 |
Cytomegalovirus test positive | 45.65 | 18.80 | 20 | 16411 | 2998 | 63469593 |
Hypotension | 45.16 | 18.80 | 164 | 16267 | 272440 | 63200151 |
Malaise | 43.51 | 18.80 | 27 | 16404 | 415927 | 63056664 |
Eosinophilia | 42.56 | 18.80 | 40 | 16391 | 22716 | 63449875 |
Clostridium difficile infection | 41.98 | 18.80 | 45 | 16386 | 29877 | 63442714 |
Cholestatic liver injury | 41.77 | 18.80 | 18 | 16413 | 2592 | 63469999 |
Dizziness | 40.85 | 18.80 | 31 | 16400 | 429894 | 63042697 |
Systemic lupus erythematosus | 39.73 | 18.80 | 4 | 16427 | 208914 | 63263677 |
Trichosporon infection | 38.93 | 18.80 | 10 | 16421 | 282 | 63472309 |
Drug ineffective for unapproved indication | 38.86 | 18.80 | 46 | 16385 | 34017 | 63438574 |
Renal impairment | 38.23 | 18.80 | 76 | 16355 | 88279 | 63384312 |
Respiratory distress | 37.33 | 18.80 | 45 | 16386 | 33906 | 63438685 |
Enterococcal infection | 37.31 | 18.80 | 24 | 16407 | 7824 | 63464767 |
Renal failure | 37.02 | 18.80 | 89 | 16342 | 117563 | 63355028 |
Mucormycosis | 36.97 | 18.80 | 17 | 16414 | 2854 | 63469737 |
Swelling | 36.25 | 18.80 | 13 | 16418 | 275365 | 63197226 |
Blood creatinine increased | 36.15 | 18.80 | 74 | 16357 | 87770 | 63384821 |
Peripheral swelling | 35.96 | 18.80 | 12 | 16419 | 265930 | 63206661 |
Therapeutic product effect decreased | 35.96 | 18.80 | 4 | 16427 | 193183 | 63279408 |
Stenotrophomonas infection | 35.83 | 18.80 | 15 | 16416 | 2012 | 63470579 |
Agranulocytosis | 35.61 | 18.80 | 38 | 16393 | 25096 | 63447495 |
Nephropathy toxic | 35.51 | 18.80 | 25 | 16406 | 9454 | 63463137 |
Bronchopulmonary aspergillosis | 35.22 | 18.80 | 24 | 16407 | 8611 | 63463980 |
Weight decreased | 34.88 | 18.80 | 14 | 16417 | 276784 | 63195807 |
Rash maculo-papular | 34.62 | 18.80 | 42 | 16389 | 31854 | 63440737 |
Product dose omission issue | 34.55 | 18.80 | 9 | 16422 | 234304 | 63238287 |
White blood cell count decreased | 34.27 | 18.80 | 96 | 16335 | 139008 | 63333583 |
Alanine aminotransferase increased | 34.27 | 18.80 | 80 | 16351 | 103690 | 63368901 |
Pseudomonas infection | 33.93 | 18.80 | 26 | 16405 | 11187 | 63461404 |
Acute respiratory failure | 33.57 | 18.80 | 43 | 16388 | 34442 | 63438149 |
Metabolic encephalopathy | 33.27 | 18.80 | 20 | 16411 | 5789 | 63466802 |
Differentiation syndrome | 33.15 | 18.80 | 12 | 16419 | 1091 | 63471500 |
Hepatic function abnormal | 32.58 | 18.80 | 44 | 16387 | 37098 | 63435493 |
Antibiotic level above therapeutic | 31.89 | 18.80 | 9 | 16422 | 365 | 63472226 |
Anaemia | 31.72 | 18.80 | 155 | 16276 | 293275 | 63179316 |
Leukopenia | 31.67 | 18.80 | 65 | 16366 | 77225 | 63395366 |
Nephritis allergic | 31.51 | 18.80 | 8 | 16423 | 215 | 63472376 |
Sinusitis | 31.04 | 18.80 | 10 | 16421 | 226643 | 63245948 |
Encephalitis Japanese B | 30.73 | 18.80 | 6 | 16425 | 45 | 63472546 |
Toxic epidermal necrolysis | 30.20 | 18.80 | 35 | 16396 | 25299 | 63447292 |
Hypertensive heart disease | 29.95 | 18.80 | 14 | 16417 | 2438 | 63470153 |
Enterococcal bacteraemia | 29.89 | 18.80 | 12 | 16419 | 1447 | 63471144 |
Pulmonary trichosporonosis | 29.56 | 18.80 | 6 | 16425 | 56 | 63472535 |
Musculoskeletal stiffness | 29.38 | 18.80 | 6 | 16425 | 184612 | 63287979 |
Toxic skin eruption | 28.71 | 18.80 | 25 | 16406 | 12860 | 63459731 |
Confusional state | 28.56 | 18.80 | 129 | 16302 | 236251 | 63236340 |
Eosinophilic pneumonia | 28.18 | 18.80 | 13 | 16418 | 2198 | 63470393 |
Graft versus host disease | 28.07 | 18.80 | 19 | 16412 | 6744 | 63465847 |
Acute myeloid leukaemia | 28.03 | 18.80 | 28 | 16403 | 17119 | 63455472 |
Leukocytosis | 27.90 | 18.80 | 34 | 16397 | 25901 | 63446690 |
Dysbiosis | 27.77 | 18.80 | 10 | 16421 | 896 | 63471695 |
Staphylococcal infection | 27.61 | 18.80 | 43 | 16388 | 41213 | 63431378 |
Hyperbilirubinaemia | 27.35 | 18.80 | 23 | 16408 | 11291 | 63461300 |
Off label use | 26.74 | 18.80 | 279 | 16152 | 674183 | 62798408 |
Pneumonia fungal | 26.72 | 18.80 | 17 | 16414 | 5438 | 63467153 |
Product use issue | 26.42 | 18.80 | 12 | 16419 | 220508 | 63252083 |
Weight increased | 25.78 | 18.80 | 18 | 16413 | 260774 | 63211817 |
Hypoaesthesia | 25.73 | 18.80 | 6 | 16425 | 168387 | 63304204 |
Disseminated intravascular coagulation | 25.58 | 18.80 | 28 | 16403 | 19023 | 63453568 |
Acute graft versus host disease in skin | 25.42 | 18.80 | 14 | 16417 | 3438 | 63469153 |
Hypersensitivity | 25.42 | 18.80 | 23 | 16408 | 292662 | 63179929 |
Tumour lysis syndrome | 25.36 | 18.80 | 20 | 16411 | 8970 | 63463621 |
Gait disturbance | 25.22 | 18.80 | 8 | 16423 | 183170 | 63289421 |
Klebsiella bacteraemia | 24.99 | 18.80 | 11 | 16420 | 1667 | 63470924 |
Tonsillitis bacterial | 24.96 | 18.80 | 6 | 16425 | 128 | 63472463 |
Chemotherapeutic drug level increased | 24.65 | 18.80 | 6 | 16425 | 135 | 63472456 |
Cholestasis | 24.50 | 18.80 | 34 | 16397 | 29400 | 63443191 |
Aphasia | 24.36 | 18.80 | 36 | 16395 | 32964 | 63439627 |
Neutropenic colitis | 24.04 | 18.80 | 13 | 16418 | 3082 | 63469509 |
Candida infection | 23.97 | 18.80 | 33 | 16398 | 28318 | 63444273 |
Pericarditis | 23.79 | 18.80 | 3 | 16428 | 131576 | 63341015 |
Metabolic acidosis | 23.50 | 18.80 | 42 | 16389 | 45027 | 63427564 |
Fall | 23.47 | 18.80 | 41 | 16390 | 392293 | 63080298 |
Engraft failure | 23.22 | 18.80 | 7 | 16424 | 359 | 63472232 |
Hyperoxaluria | 23.10 | 18.80 | 6 | 16425 | 177 | 63472414 |
Stress cardiomyopathy | 22.41 | 18.80 | 19 | 16412 | 9431 | 63463160 |
Neutrophilia | 22.25 | 18.80 | 14 | 16417 | 4392 | 63468199 |
Eosinophilic pneumonia acute | 22.17 | 18.80 | 7 | 16424 | 419 | 63472172 |
Cytomegalovirus viraemia | 21.39 | 18.80 | 15 | 16416 | 5634 | 63466957 |
Pseudomembranous colitis | 21.23 | 18.80 | 12 | 16419 | 3100 | 63469491 |
Muscle spasms | 21.17 | 18.80 | 7 | 16424 | 156143 | 63316448 |
Blood bilirubin increased | 21.17 | 18.80 | 36 | 16395 | 37104 | 63435487 |
Venoocclusive liver disease | 21.06 | 18.80 | 14 | 16417 | 4821 | 63467770 |
Altered state of consciousness | 20.78 | 18.80 | 29 | 16402 | 25201 | 63447390 |
Asthma | 20.60 | 18.80 | 4 | 16427 | 127557 | 63345034 |
Thrombotic microangiopathy | 20.58 | 18.80 | 19 | 16412 | 10542 | 63462049 |
Meningitis bacterial | 20.48 | 18.80 | 9 | 16422 | 1358 | 63471233 |
Seizure | 20.41 | 18.80 | 78 | 16353 | 132556 | 63340035 |
Ileus | 20.39 | 18.80 | 22 | 16409 | 14703 | 63457888 |
Pulmonary haemorrhage | 20.31 | 18.80 | 16 | 16415 | 7165 | 63465426 |
Enterococcal sepsis | 20.17 | 18.80 | 9 | 16422 | 1409 | 63471182 |
Respiratory alkalosis | 20.02 | 18.80 | 11 | 16420 | 2690 | 63469901 |
Pleural effusion | 19.76 | 18.80 | 61 | 16370 | 93149 | 63379442 |
Small intestinal obstruction | 19.66 | 18.80 | 24 | 16407 | 18313 | 63454278 |
Lower respiratory tract infection | 19.65 | 18.80 | 5 | 16426 | 132302 | 63340289 |
Laryngeal inflammation | 19.57 | 18.80 | 5 | 16426 | 138 | 63472453 |
Pain in extremity | 19.49 | 18.80 | 35 | 16396 | 331451 | 63141140 |
Angiokeratoma | 19.33 | 18.80 | 5 | 16426 | 145 | 63472446 |
Electrocardiogram T wave alternans | 19.28 | 18.80 | 4 | 16427 | 42 | 63472549 |
Delirium | 18.95 | 18.80 | 41 | 16390 | 50500 | 63422091 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Encephalopathy | 248.14 | 16.07 | 191 | 21117 | 35128 | 34900495 |
Acute kidney injury | 247.87 | 16.07 | 561 | 20747 | 304427 | 34631196 |
Neurotoxicity | 192.78 | 16.07 | 126 | 21182 | 17884 | 34917739 |
Cytokine release syndrome | 178.97 | 16.07 | 132 | 21176 | 22745 | 34912878 |
Febrile neutropenia | 172.39 | 16.07 | 303 | 21005 | 136546 | 34799077 |
Drug reaction with eosinophilia and systemic symptoms | 163.83 | 16.07 | 146 | 21162 | 32866 | 34902757 |
Septic shock | 131.68 | 16.07 | 189 | 21119 | 71645 | 34863978 |
Respiratory failure | 102.67 | 16.07 | 213 | 21095 | 108359 | 34827264 |
Multiple organ dysfunction syndrome | 102.03 | 16.07 | 174 | 21134 | 76392 | 34859231 |
Pyrexia | 89.49 | 16.07 | 420 | 20888 | 332593 | 34603030 |
Fatigue | 87.03 | 16.07 | 60 | 21248 | 370593 | 34565030 |
Hypoxia | 78.40 | 16.07 | 129 | 21179 | 54966 | 34880657 |
Immune effector cell-associated neurotoxicity syndrome | 77.18 | 16.07 | 40 | 21268 | 3673 | 34931950 |
Renal tubular necrosis | 77.04 | 16.07 | 69 | 21239 | 15611 | 34920012 |
Pathogen resistance | 77.01 | 16.07 | 56 | 21252 | 9426 | 34926197 |
Clostridium difficile colitis | 74.88 | 16.07 | 68 | 21240 | 15662 | 34919961 |
Acute generalised exanthematous pustulosis | 73.91 | 16.07 | 48 | 21260 | 6728 | 34928895 |
Sepsis | 73.73 | 16.07 | 246 | 21062 | 166315 | 34769308 |
Mental status changes | 69.40 | 16.07 | 100 | 21208 | 37983 | 34897640 |
Myoclonus | 68.81 | 16.07 | 63 | 21245 | 14662 | 34920961 |
Tubulointerstitial nephritis | 68.66 | 16.07 | 74 | 21234 | 20950 | 34914673 |
Neutrophil count decreased | 66.52 | 16.07 | 115 | 21193 | 50989 | 34884634 |
Dizziness | 61.79 | 16.07 | 28 | 21280 | 218493 | 34717130 |
Methaemoglobinaemia | 56.13 | 16.07 | 32 | 21276 | 3549 | 34932074 |
Product dose omission issue | 54.68 | 16.07 | 5 | 21303 | 119706 | 34815917 |
Enterococcal infection | 53.91 | 16.07 | 45 | 21263 | 9261 | 34926362 |
Death | 49.29 | 16.07 | 106 | 21202 | 397943 | 34537680 |
Neutropenia | 48.85 | 16.07 | 207 | 21101 | 156571 | 34779052 |
Bacteraemia | 46.95 | 16.07 | 59 | 21249 | 19658 | 34915965 |
Disseminated intravascular coagulation | 46.80 | 16.07 | 62 | 21246 | 21754 | 34913869 |
Pseudomonas infection | 46.54 | 16.07 | 47 | 21261 | 12335 | 34923288 |
Bronchopulmonary aspergillosis | 43.36 | 16.07 | 49 | 21259 | 14610 | 34921013 |
Meningitis candida | 43.16 | 16.07 | 10 | 21298 | 71 | 34935552 |
Brain herniation | 42.75 | 16.07 | 28 | 21280 | 3980 | 34931643 |
Status epilepticus | 42.23 | 16.07 | 45 | 21263 | 12569 | 34923054 |
Haemodialysis | 41.49 | 16.07 | 41 | 21267 | 10485 | 34925138 |
Immune thrombocytopenia | 40.51 | 16.07 | 38 | 21270 | 9114 | 34926509 |
Myocardial infarction | 40.10 | 16.07 | 12 | 21296 | 121073 | 34814550 |
Septic embolus | 39.48 | 16.07 | 18 | 21290 | 1247 | 34934376 |
Nephropathy toxic | 38.81 | 16.07 | 43 | 21265 | 12545 | 34923078 |
Aspergillus infection | 38.03 | 16.07 | 42 | 21266 | 12212 | 34923411 |
Platelet count decreased | 37.98 | 16.07 | 159 | 21149 | 119558 | 34816065 |
Arthralgia | 37.84 | 16.07 | 29 | 21279 | 170012 | 34765611 |
Drug resistance | 37.24 | 16.07 | 61 | 21247 | 25866 | 34909757 |
Acute respiratory distress syndrome | 37.17 | 16.07 | 61 | 21247 | 25908 | 34909715 |
Fall | 36.47 | 16.07 | 42 | 21266 | 202843 | 34732780 |
Botulism | 35.74 | 16.07 | 10 | 21298 | 161 | 34935462 |
Thrombocytopenia | 34.61 | 16.07 | 187 | 21121 | 156060 | 34779563 |
Confusional state | 34.31 | 16.07 | 176 | 21132 | 143984 | 34791639 |
Blood culture positive | 33.82 | 16.07 | 26 | 21282 | 4757 | 34930866 |
White blood cell count decreased | 33.63 | 16.07 | 131 | 21177 | 95314 | 34840309 |
Aspartate aminotransferase increased | 33.41 | 16.07 | 104 | 21204 | 67679 | 34867944 |
Depression | 33.29 | 16.07 | 9 | 21299 | 97089 | 34838534 |
Glomerulosclerosis | 32.95 | 16.07 | 14 | 21294 | 819 | 34934804 |
Systemic candida | 32.53 | 16.07 | 23 | 21285 | 3703 | 34931920 |
Clostridium difficile infection | 32.06 | 16.07 | 48 | 21260 | 18850 | 34916773 |
Pain | 32.02 | 16.07 | 47 | 21261 | 204628 | 34730995 |
Antibiotic level above therapeutic | 31.95 | 16.07 | 10 | 21298 | 241 | 34935382 |
Drug ineffective for unapproved indication | 31.66 | 16.07 | 54 | 21254 | 23661 | 34911962 |
Cholestasis | 31.64 | 16.07 | 58 | 21250 | 26890 | 34908733 |
Eosinophilia | 30.23 | 16.07 | 56 | 21252 | 26166 | 34909457 |
Insomnia | 29.81 | 16.07 | 13 | 21295 | 103894 | 34831729 |
Toxic encephalopathy | 29.61 | 16.07 | 25 | 21283 | 5224 | 34930399 |
Haemophagocytic lymphohistiocytosis | 29.58 | 16.07 | 38 | 21270 | 12935 | 34922688 |
Klebsiella infection | 29.56 | 16.07 | 31 | 21277 | 8500 | 34927123 |
Cytomegalovirus viraemia | 29.39 | 16.07 | 29 | 21279 | 7401 | 34928222 |
Uraemic encephalopathy | 29.09 | 16.07 | 10 | 21298 | 326 | 34935297 |
Weight decreased | 29.04 | 16.07 | 39 | 21269 | 176262 | 34759361 |
Mucormycosis | 28.88 | 16.07 | 26 | 21282 | 5916 | 34929707 |
Cytomegalovirus enterocolitis | 27.47 | 16.07 | 13 | 21295 | 981 | 34934642 |
Candida infection | 27.24 | 16.07 | 43 | 21265 | 17672 | 34917951 |
Toxic epidermal necrolysis | 27.21 | 16.07 | 48 | 21260 | 21598 | 34914025 |
Gait disturbance | 27.17 | 16.07 | 9 | 21299 | 85131 | 34850492 |
Burkholderia test positive | 27.11 | 16.07 | 13 | 21295 | 1010 | 34934613 |
Blood pressure increased | 26.94 | 16.07 | 10 | 21298 | 88092 | 34847531 |
Drug ineffective | 25.96 | 16.07 | 406 | 20902 | 456345 | 34479278 |
Dyspnoea | 25.92 | 16.07 | 130 | 21178 | 376652 | 34558971 |
Enterocolitis | 25.75 | 16.07 | 28 | 21280 | 7998 | 34927625 |
Metabolic encephalopathy | 25.36 | 16.07 | 21 | 21287 | 4271 | 34931352 |
Cytokine storm | 25.03 | 16.07 | 11 | 21297 | 699 | 34934924 |
Anxiety | 24.71 | 16.07 | 15 | 21293 | 99413 | 34836210 |
Off label use | 24.62 | 16.07 | 375 | 20933 | 419149 | 34516474 |
Alanine aminotransferase increased | 24.57 | 16.07 | 106 | 21202 | 80709 | 34854914 |
Disseminated mucormycosis | 24.47 | 16.07 | 10 | 21298 | 530 | 34935093 |
Headache | 24.26 | 16.07 | 54 | 21254 | 200581 | 34735042 |
Pleural effusion | 24.06 | 16.07 | 106 | 21202 | 81440 | 34854183 |
Respiratory distress | 23.71 | 16.07 | 61 | 21247 | 35604 | 34900019 |
Joint swelling | 23.69 | 16.07 | 4 | 21304 | 59886 | 34875737 |
Feeling abnormal | 23.36 | 16.07 | 5 | 21303 | 63230 | 34872393 |
Bacterial toxaemia | 23.32 | 16.07 | 7 | 21301 | 146 | 34935477 |
Malaise | 23.31 | 16.07 | 49 | 21259 | 185776 | 34749847 |
Asthenia | 22.89 | 16.07 | 75 | 21233 | 245176 | 34690447 |
Peripheral swelling | 22.88 | 16.07 | 9 | 21299 | 76532 | 34859091 |
Inappropriate schedule of product administration | 22.86 | 16.07 | 5 | 21303 | 62291 | 34873332 |
Acute respiratory failure | 22.77 | 16.07 | 55 | 21253 | 30873 | 34904750 |
Acute myeloid leukaemia recurrent | 22.75 | 16.07 | 15 | 21293 | 2155 | 34933468 |
Choluria | 22.64 | 16.07 | 7 | 21301 | 162 | 34935461 |
Rash morbilliform | 22.31 | 16.07 | 17 | 21291 | 3070 | 34932553 |
Transaminases increased | 22.27 | 16.07 | 50 | 21258 | 26773 | 34908850 |
Delirium | 22.13 | 16.07 | 68 | 21240 | 43923 | 34891700 |
Renal failure | 21.68 | 16.07 | 145 | 21163 | 130412 | 34805211 |
Trichosporon infection | 21.52 | 16.07 | 10 | 21298 | 724 | 34934899 |
Blood creatinine increased | 21.21 | 16.07 | 114 | 21194 | 94862 | 34840761 |
Hypersensitivity vasculitis | 21.14 | 16.07 | 17 | 21291 | 3318 | 34932305 |
Acute myeloid leukaemia | 21.04 | 16.07 | 39 | 21269 | 18231 | 34917392 |
Drug-induced liver injury | 20.94 | 16.07 | 51 | 21257 | 28781 | 34906842 |
Fungal infection | 20.89 | 16.07 | 36 | 21272 | 15899 | 34919724 |
Leukoerythroblastosis | 20.43 | 16.07 | 5 | 21303 | 46 | 34935577 |
Cerebral aspergillosis | 20.33 | 16.07 | 12 | 21296 | 1420 | 34934203 |
Kidney fibrosis | 20.02 | 16.07 | 14 | 21294 | 2214 | 34933409 |
Corynebacterium infection | 19.84 | 16.07 | 9 | 21299 | 616 | 34935007 |
Drug intolerance | 19.53 | 16.07 | 6 | 21302 | 59564 | 34876059 |
Systemic mycosis | 19.29 | 16.07 | 12 | 21296 | 1561 | 34934062 |
Aphasia | 18.95 | 16.07 | 41 | 21267 | 21413 | 34914210 |
Musculoskeletal stiffness | 18.72 | 16.07 | 3 | 21305 | 46677 | 34888946 |
Lactobacillus infection | 18.56 | 16.07 | 7 | 21301 | 299 | 34935324 |
Pneumonia bacterial | 18.50 | 16.07 | 29 | 21279 | 11843 | 34923780 |
Vanishing bile duct syndrome | 18.42 | 16.07 | 10 | 21298 | 1008 | 34934615 |
Agranulocytosis | 18.22 | 16.07 | 43 | 21265 | 23778 | 34911845 |
Acute lymphocytic leukaemia recurrent | 18.21 | 16.07 | 15 | 21293 | 3029 | 34932594 |
Nasopharyngitis | 18.17 | 16.07 | 10 | 21298 | 69958 | 34865665 |
Procalcitonin increased | 18.11 | 16.07 | 12 | 21296 | 1739 | 34933884 |
Disseminated cryptococcosis | 18.08 | 16.07 | 11 | 21297 | 1375 | 34934248 |
Sputum culture positive | 17.88 | 16.07 | 12 | 21296 | 1776 | 34933847 |
Hypotension | 17.86 | 16.07 | 210 | 21098 | 221439 | 34714184 |
Flavobacterium infection | 17.84 | 16.07 | 5 | 21303 | 81 | 34935542 |
Pancytopenia | 17.83 | 16.07 | 109 | 21199 | 95048 | 34840575 |
Differentiation syndrome | 17.71 | 16.07 | 11 | 21297 | 1427 | 34934196 |
Organising pneumonia | 17.70 | 16.07 | 20 | 21288 | 5959 | 34929664 |
Muscle spasms | 17.69 | 16.07 | 12 | 21296 | 74989 | 34860634 |
Pneumonia | 17.48 | 16.07 | 314 | 20994 | 362313 | 34573310 |
Enterococcal bacteraemia | 17.24 | 16.07 | 12 | 21296 | 1885 | 34933738 |
Pulmonary haemorrhage | 17.23 | 16.07 | 26 | 21282 | 10278 | 34925345 |
Unresponsive to stimuli | 17.15 | 16.07 | 46 | 21262 | 27523 | 34908100 |
Eye infection fungal | 17.09 | 16.07 | 7 | 21301 | 373 | 34935250 |
Pain in extremity | 17.02 | 16.07 | 32 | 21276 | 126481 | 34809142 |
Retinal ischaemia | 16.97 | 16.07 | 7 | 21301 | 380 | 34935243 |
Dialysis | 16.95 | 16.07 | 27 | 21281 | 11181 | 34924442 |
Memory impairment | 16.89 | 16.07 | 3 | 21305 | 43315 | 34892308 |
Enterobacter infection | 16.72 | 16.07 | 13 | 21295 | 2417 | 34933206 |
Tumour lysis syndrome | 16.69 | 16.07 | 34 | 21274 | 17025 | 34918598 |
Staphylococcal sepsis | 16.69 | 16.07 | 25 | 21283 | 9819 | 34925804 |
Adenoviral haemorrhagic cystitis | 16.51 | 16.07 | 7 | 21301 | 407 | 34935216 |
Drug eruption | 16.41 | 16.07 | 37 | 21271 | 19861 | 34915762 |
Hepatosplenic candidiasis | 16.29 | 16.07 | 6 | 21302 | 240 | 34935383 |
Nausea | 16.27 | 16.07 | 131 | 21177 | 339777 | 34595846 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Encephalopathy | 641.01 | 15.98 | 390 | 35219 | 67007 | 79641772 |
Acute kidney injury | 540.85 | 15.98 | 887 | 34722 | 518517 | 79190262 |
Neurotoxicity | 415.02 | 15.98 | 228 | 35381 | 32290 | 79676489 |
Febrile neutropenia | 393.00 | 15.98 | 499 | 35110 | 230500 | 79478279 |
Drug reaction with eosinophilia and systemic symptoms | 351.41 | 15.98 | 264 | 35345 | 63980 | 79644799 |
Cytokine release syndrome | 336.01 | 15.98 | 206 | 35403 | 35792 | 79672987 |
Septic shock | 238.65 | 15.98 | 284 | 35325 | 122517 | 79586262 |
Multiple organ dysfunction syndrome | 213.98 | 15.98 | 266 | 35343 | 119980 | 79588799 |
Status epilepticus | 210.19 | 15.98 | 134 | 35475 | 24907 | 79683872 |
Myoclonus | 190.90 | 15.98 | 131 | 35478 | 27529 | 79681250 |
Pyrexia | 185.39 | 15.98 | 693 | 34916 | 678016 | 79030763 |
Sepsis | 182.95 | 15.98 | 384 | 35225 | 269044 | 79439735 |
Respiratory failure | 180.36 | 15.98 | 304 | 35305 | 180607 | 79528172 |
Mental status changes | 173.34 | 15.98 | 180 | 35429 | 66779 | 79642000 |
Thrombocytopenia | 151.70 | 15.98 | 353 | 35256 | 264906 | 79443873 |
Immune effector cell-associated neurotoxicity syndrome | 149.83 | 15.98 | 66 | 35543 | 5782 | 79702997 |
Acute generalised exanthematous pustulosis | 146.45 | 15.98 | 93 | 35516 | 17161 | 79691618 |
Tubulointerstitial nephritis | 145.09 | 15.98 | 127 | 35482 | 38108 | 79670671 |
Fatigue | 144.97 | 15.98 | 122 | 35487 | 929605 | 78779174 |
Renal tubular necrosis | 137.01 | 15.98 | 103 | 35506 | 24936 | 79683843 |
Pain | 137.01 | 15.98 | 72 | 35537 | 703730 | 79005049 |
Hypoxia | 129.75 | 15.98 | 193 | 35416 | 103050 | 79605729 |
Arthralgia | 127.71 | 15.98 | 48 | 35561 | 571755 | 79137024 |
Clostridium difficile colitis | 126.05 | 15.98 | 109 | 35500 | 32174 | 79676605 |
Neutrophil count decreased | 124.36 | 15.98 | 180 | 35429 | 93779 | 79615000 |
Neutropenia | 120.98 | 15.98 | 341 | 35268 | 287369 | 79421410 |
Pathogen resistance | 118.48 | 15.98 | 76 | 35533 | 14266 | 79694513 |
Dizziness | 109.73 | 15.98 | 49 | 35560 | 526392 | 79182387 |
Platelet count decreased | 106.76 | 15.98 | 255 | 35354 | 194409 | 79514370 |
Joint swelling | 104.70 | 15.98 | 6 | 35603 | 288640 | 79420139 |
Drug resistance | 101.24 | 15.98 | 109 | 35500 | 42104 | 79666675 |
Toxic encephalopathy | 100.43 | 15.98 | 63 | 35546 | 11377 | 79697402 |
Bacteraemia | 89.90 | 15.98 | 91 | 35518 | 32733 | 79676046 |
Headache | 88.60 | 15.98 | 97 | 35512 | 653675 | 79055104 |
Enterococcal infection | 86.96 | 15.98 | 65 | 35544 | 15595 | 79693184 |
Klebsiella infection | 84.52 | 15.98 | 64 | 35545 | 15656 | 79693123 |
Drug intolerance | 81.01 | 15.98 | 11 | 35598 | 264108 | 79444671 |
Product dose omission issue | 79.11 | 15.98 | 9 | 35600 | 247528 | 79461251 |
Acute respiratory distress syndrome | 77.50 | 15.98 | 97 | 35512 | 43970 | 79664809 |
Malaise | 73.99 | 15.98 | 66 | 35543 | 489803 | 79218976 |
Rheumatoid arthritis | 73.58 | 15.98 | 5 | 35604 | 208465 | 79500314 |
Nasopharyngitis | 72.36 | 15.98 | 13 | 35596 | 253868 | 79454911 |
Pneumonia | 71.77 | 15.98 | 522 | 35087 | 659724 | 79049055 |
Bronchopulmonary aspergillosis | 70.74 | 15.98 | 67 | 35542 | 22227 | 79686552 |
Nephropathy toxic | 69.87 | 15.98 | 64 | 35545 | 20355 | 79688424 |
Pseudomonas infection | 68.59 | 15.98 | 64 | 35545 | 20839 | 79687940 |
Disseminated intravascular coagulation | 68.04 | 15.98 | 82 | 35527 | 35760 | 79673019 |
Alopecia | 67.79 | 15.98 | 11 | 35598 | 231344 | 79477435 |
Aspartate aminotransferase increased | 66.86 | 15.98 | 173 | 35436 | 138468 | 79570311 |
Peripheral swelling | 66.46 | 15.98 | 19 | 35590 | 269598 | 79439181 |
Eosinophilia | 66.07 | 15.98 | 91 | 35518 | 45254 | 79663525 |
White blood cell count decreased | 64.70 | 15.98 | 208 | 35401 | 188080 | 79520699 |
Clostridium difficile infection | 64.22 | 15.98 | 87 | 35522 | 42598 | 79666181 |
Pancytopenia | 63.33 | 15.98 | 190 | 35419 | 165555 | 79543224 |
Arthropathy | 63.23 | 15.98 | 4 | 35605 | 177107 | 79531672 |
Abdominal discomfort | 63.04 | 15.98 | 17 | 35592 | 250710 | 79458069 |
Mucormycosis | 62.92 | 15.98 | 42 | 35567 | 8427 | 79700352 |
Fall | 60.98 | 15.98 | 77 | 35532 | 487552 | 79221227 |
Therapeutic product effect decreased | 60.66 | 15.98 | 3 | 35606 | 163860 | 79544919 |
Drug ineffective for unapproved indication | 60.37 | 15.98 | 93 | 35516 | 51145 | 79657634 |
Renal failure | 59.34 | 15.98 | 211 | 35398 | 200757 | 79508022 |
Blood creatinine increased | 57.59 | 15.98 | 176 | 35433 | 154881 | 79553898 |
Methaemoglobinaemia | 57.49 | 15.98 | 34 | 35575 | 5523 | 79703256 |
Weight decreased | 57.10 | 15.98 | 45 | 35564 | 355153 | 79353626 |
Trichosporon infection | 56.34 | 15.98 | 20 | 35589 | 988 | 79707791 |
Brain herniation | 55.41 | 15.98 | 37 | 35572 | 7426 | 79701353 |
Confusional state | 55.14 | 15.98 | 284 | 35325 | 317713 | 79391066 |
Cholestasis | 55.07 | 15.98 | 90 | 35519 | 52019 | 79656760 |
Antibiotic level above therapeutic | 54.29 | 15.98 | 18 | 35591 | 722 | 79708057 |
Metabolic encephalopathy | 53.10 | 15.98 | 39 | 35570 | 9108 | 79699671 |
Haemodialysis | 52.75 | 15.98 | 52 | 35557 | 18116 | 79690663 |
Toxic epidermal necrolysis | 51.23 | 15.98 | 80 | 35529 | 44501 | 79664278 |
Acute respiratory failure | 50.10 | 15.98 | 93 | 35516 | 59448 | 79649331 |
Shock | 49.84 | 15.98 | 78 | 35531 | 43470 | 79665309 |
Musculoskeletal stiffness | 49.76 | 15.98 | 9 | 35600 | 174999 | 79533780 |
Agranulocytosis | 49.26 | 15.98 | 79 | 35530 | 44951 | 79663828 |
Septic embolus | 48.86 | 15.98 | 22 | 35587 | 2029 | 79706750 |
Gait disturbance | 48.64 | 15.98 | 16 | 35593 | 207490 | 79501289 |
Off label use | 48.33 | 15.98 | 617 | 34992 | 906598 | 78802181 |
Alanine aminotransferase increased | 48.24 | 15.98 | 171 | 35438 | 162399 | 79546380 |
Haemophagocytic lymphohistiocytosis | 48.21 | 15.98 | 54 | 35555 | 21783 | 79686996 |
Hypotension | 48.21 | 15.98 | 349 | 35260 | 439968 | 79268811 |
Fungaemia | 47.26 | 15.98 | 28 | 35581 | 4563 | 79704216 |
Pleural effusion | 46.76 | 15.98 | 157 | 35452 | 145105 | 79563674 |
Respiratory distress | 46.45 | 15.98 | 89 | 35520 | 58250 | 79650529 |
Pain in extremity | 46.13 | 15.98 | 57 | 35552 | 364481 | 79344298 |
Dyspnoea | 45.89 | 15.98 | 212 | 35397 | 856813 | 78851966 |
Differentiation syndrome | 44.51 | 15.98 | 22 | 35587 | 2502 | 79706277 |
Neutropenic colitis | 44.08 | 15.98 | 29 | 35580 | 5678 | 79703101 |
Depression | 43.79 | 15.98 | 21 | 35588 | 216769 | 79492010 |
Cytomegalovirus viraemia | 43.50 | 15.98 | 40 | 35569 | 12781 | 79695998 |
Nausea | 43.25 | 15.98 | 251 | 35358 | 956945 | 78751834 |
Candida infection | 43.11 | 15.98 | 68 | 35541 | 38146 | 79670633 |
Cholestatic liver injury | 42.84 | 15.98 | 27 | 35582 | 4914 | 79703865 |
Insomnia | 42.05 | 15.98 | 29 | 35580 | 245141 | 79463638 |
Acute myeloid leukaemia | 42.04 | 15.98 | 60 | 35549 | 30825 | 79677954 |
Blood pressure increased | 41.90 | 15.98 | 21 | 35588 | 211339 | 79497440 |
Myocardial infarction | 41.76 | 15.98 | 15 | 35594 | 184114 | 79524665 |
Weight increased | 41.07 | 15.98 | 38 | 35571 | 277348 | 79431431 |
Tumour lysis syndrome | 40.98 | 15.98 | 52 | 35557 | 23887 | 79684892 |
Meningitis candida | 40.53 | 15.98 | 10 | 35599 | 134 | 79708645 |
Delirium | 40.16 | 15.98 | 105 | 35504 | 84522 | 79624257 |
Hypoaesthesia | 40.02 | 15.98 | 15 | 35594 | 179337 | 79529442 |
Systemic candida | 39.85 | 15.98 | 29 | 35580 | 6677 | 79702102 |
Staphylococcal infection | 39.32 | 15.98 | 83 | 35526 | 58212 | 79650567 |
Enterocolitis | 39.30 | 15.98 | 40 | 35569 | 14472 | 79694307 |
Immune thrombocytopenia | 39.25 | 15.98 | 44 | 35565 | 17761 | 79691018 |
Pulmonary haemorrhage | 38.83 | 15.98 | 40 | 35569 | 14677 | 79694102 |
Blood bilirubin increased | 38.68 | 15.98 | 89 | 35520 | 66143 | 79642636 |
Asthma | 38.29 | 15.98 | 7 | 35602 | 135088 | 79573691 |
Aspergillus infection | 38.28 | 15.98 | 45 | 35564 | 19116 | 79689663 |
Drug-induced liver injury | 36.59 | 15.98 | 87 | 35522 | 66030 | 79642749 |
Renal impairment | 36.20 | 15.98 | 153 | 35456 | 157630 | 79551149 |
Aphasia | 35.62 | 15.98 | 70 | 35539 | 46662 | 79662117 |
Enterococcal bacteraemia | 34.99 | 15.98 | 20 | 35589 | 3048 | 79705731 |
Arthritis | 34.69 | 15.98 | 5 | 35604 | 114875 | 79593904 |
Discomfort | 34.56 | 15.98 | 7 | 35602 | 125610 | 79583169 |
Feeling abnormal | 34.39 | 15.98 | 14 | 35595 | 159185 | 79549594 |
Pneumonia fungal | 34.25 | 15.98 | 33 | 35576 | 11177 | 79697602 |
Lower respiratory tract infection | 33.93 | 15.98 | 8 | 35601 | 129212 | 79579567 |
Sinusitis | 33.68 | 15.98 | 23 | 35586 | 195478 | 79513301 |
Muscle spasms | 33.68 | 15.98 | 18 | 35591 | 174712 | 79534067 |
Swelling | 32.89 | 15.98 | 29 | 35580 | 216682 | 79492097 |
Systemic lupus erythematosus | 32.82 | 15.98 | 7 | 35602 | 121142 | 79587637 |
Mixed liver injury | 32.47 | 15.98 | 27 | 35582 | 7551 | 79701228 |
Injection site pain | 32.25 | 15.98 | 9 | 35600 | 129829 | 79578950 |
Drug level increased | 32.19 | 15.98 | 61 | 35548 | 39590 | 79669189 |
Blood culture positive | 31.96 | 15.98 | 28 | 35581 | 8401 | 79700378 |
Liver abscess | 31.12 | 15.98 | 24 | 35585 | 6030 | 79702749 |
Pulmonary trichosporonosis | 31.01 | 15.98 | 7 | 35602 | 62 | 79708717 |
Hepatic function abnormal | 30.97 | 15.98 | 87 | 35522 | 73020 | 79635759 |
Cytomegalovirus enterocolitis | 30.90 | 15.98 | 15 | 35594 | 1640 | 79707139 |
Rash morbilliform | 30.78 | 15.98 | 24 | 35585 | 6126 | 79702653 |
Botulism | 30.66 | 15.98 | 10 | 35599 | 381 | 79708398 |
Leukocytosis | 30.62 | 15.98 | 63 | 35546 | 43392 | 79665387 |
Balance disorder | 30.56 | 15.98 | 4 | 35605 | 98853 | 79609926 |
Anxiety | 30.23 | 15.98 | 40 | 35569 | 248472 | 79460307 |
Rash maculo-papular | 30.18 | 15.98 | 73 | 35536 | 56005 | 79652774 |
Paraesthesia | 30.03 | 15.98 | 21 | 35588 | 176302 | 79532477 |
Leukopenia | 29.90 | 15.98 | 117 | 35492 | 116396 | 79592383 |
Glomerulosclerosis | 29.83 | 15.98 | 13 | 35596 | 1109 | 79707670 |
Cytomegalovirus test positive | 29.32 | 15.98 | 23 | 35586 | 5924 | 79702855 |
Enterococcal sepsis | 29.04 | 15.98 | 17 | 35592 | 2709 | 79706070 |
Uraemic encephalopathy | 28.68 | 15.98 | 11 | 35598 | 676 | 79708103 |
Back pain | 28.56 | 15.98 | 58 | 35551 | 304122 | 79404657 |
Pneumonia bacterial | 28.46 | 15.98 | 39 | 35570 | 19292 | 79689487 |
Gastrooesophageal reflux disease | 28.28 | 15.98 | 6 | 35603 | 104240 | 79604539 |
Contusion | 27.69 | 15.98 | 16 | 35593 | 148760 | 79560019 |
Drug ineffective | 27.14 | 15.98 | 652 | 34957 | 1080261 | 78628518 |
Engraftment syndrome | 27.00 | 15.98 | 13 | 35596 | 1396 | 79707383 |
Blood cholesterol increased | 26.83 | 15.98 | 3 | 35606 | 83717 | 79625062 |
Graft versus host disease | 26.29 | 15.98 | 33 | 35576 | 14993 | 79693786 |
Dry mouth | 26.18 | 15.98 | 4 | 35605 | 88015 | 79620764 |
Dyspepsia | 26.13 | 15.98 | 8 | 35601 | 108679 | 79600100 |
Venoocclusive liver disease | 25.79 | 15.98 | 29 | 35580 | 11742 | 79697037 |
Drug eruption | 25.60 | 15.98 | 59 | 35550 | 43876 | 79664903 |
Chest pain | 25.51 | 15.98 | 55 | 35554 | 282249 | 79426530 |
Asthenia | 25.31 | 15.98 | 130 | 35479 | 511559 | 79197220 |
Cardiac arrest | 25.26 | 15.98 | 147 | 35462 | 171949 | 79536830 |
Abdominal pain upper | 25.25 | 15.98 | 38 | 35571 | 223781 | 79484998 |
Encephalitis Japanese B | 25.24 | 15.98 | 6 | 35603 | 68 | 79708711 |
Unresponsive to stimuli | 25.22 | 15.98 | 68 | 35541 | 55720 | 79653059 |
Bacterial toxaemia | 25.04 | 15.98 | 7 | 35602 | 156 | 79708623 |
Procalcitonin increased | 25.00 | 15.98 | 16 | 35593 | 2990 | 79705789 |
Nephritis allergic | 24.56 | 15.98 | 10 | 35599 | 720 | 79708059 |
Activated partial thromboplastin time prolonged | 24.50 | 15.98 | 31 | 35578 | 14197 | 79694582 |
Pericarditis | 24.48 | 15.98 | 8 | 35601 | 104228 | 79604551 |
Disseminated mucormycosis | 24.33 | 15.98 | 10 | 35599 | 738 | 79708041 |
Systemic mycosis | 24.20 | 15.98 | 15 | 35594 | 2651 | 79706128 |
Loss of personal independence in daily activities | 23.87 | 15.98 | 8 | 35601 | 102572 | 79606207 |
Meningitis bacterial | 23.86 | 15.98 | 15 | 35594 | 2717 | 79706062 |
Memory impairment | 23.84 | 15.98 | 10 | 35599 | 111724 | 79597055 |
Disseminated cryptococcosis | 23.76 | 15.98 | 13 | 35596 | 1821 | 79706958 |
Osteoarthritis | 23.73 | 15.98 | 5 | 35604 | 87304 | 79621475 |
Blood urea increased | 23.61 | 15.98 | 61 | 35548 | 48729 | 79660050 |
Small intestinal obstruction | 23.44 | 15.98 | 43 | 35566 | 27229 | 79681550 |
Transaminases increased | 23.32 | 15.98 | 63 | 35546 | 51680 | 79657099 |
Enterobacter infection | 23.26 | 15.98 | 18 | 35591 | 4544 | 79704235 |
Burkholderia test positive | 23.12 | 15.98 | 9 | 35600 | 576 | 79708203 |
Hypersensitivity | 22.95 | 15.98 | 52 | 35557 | 262187 | 79446592 |
Intentional product misuse | 22.89 | 15.98 | 7 | 35602 | 95158 | 79613621 |
Serum ferritin increased | 22.85 | 15.98 | 25 | 35584 | 9822 | 79698957 |
Hyperbilirubinaemia | 22.79 | 15.98 | 40 | 35569 | 24478 | 79684301 |
Pseudomembranous colitis | 22.72 | 15.98 | 19 | 35590 | 5355 | 79703424 |
Acute lymphocytic leukaemia recurrent | 22.70 | 15.98 | 18 | 35591 | 4706 | 79704073 |
Inappropriate schedule of product administration | 22.64 | 15.98 | 16 | 35593 | 133612 | 79575167 |
Device related infection | 22.17 | 15.98 | 48 | 35561 | 34246 | 79674533 |
Lung infiltration | 22.10 | 15.98 | 38 | 35571 | 22874 | 79685905 |
Clostridial infection | 21.70 | 15.98 | 19 | 35590 | 5695 | 79703084 |
Corynebacterium infection | 21.64 | 15.98 | 11 | 35598 | 1327 | 79707452 |
Chest discomfort | 21.51 | 15.98 | 18 | 35591 | 138026 | 79570753 |
Vanishing bile duct syndrome | 21.38 | 15.98 | 12 | 35597 | 1766 | 79707013 |
Systemic inflammatory response syndrome | 21.38 | 15.98 | 26 | 35583 | 11439 | 79697340 |
Escherichia bacteraemia | 21.35 | 15.98 | 20 | 35589 | 6542 | 79702237 |
Cerebral aspergillosis | 21.27 | 15.98 | 12 | 35597 | 1784 | 79706995 |
Cytokine storm | 21.11 | 15.98 | 10 | 35599 | 1036 | 79707743 |
Acidosis | 20.69 | 15.98 | 34 | 35575 | 19728 | 79689051 |
Eosinophilic pneumonia acute | 20.65 | 15.98 | 10 | 35599 | 1088 | 79707691 |
COVID-19 pneumonia | 20.53 | 15.98 | 42 | 35567 | 28807 | 79679972 |
Device related sepsis | 20.26 | 15.98 | 19 | 35590 | 6221 | 79702558 |
Tonsillitis bacterial | 20.16 | 15.98 | 6 | 35603 | 168 | 79708611 |
Klebsiella bacteraemia | 20.15 | 15.98 | 14 | 35595 | 2996 | 79705783 |
Product use in unapproved indication | 20.05 | 15.98 | 185 | 35424 | 250174 | 79458605 |
Pulseless electrical activity | 19.99 | 15.98 | 28 | 35581 | 14132 | 79694647 |
Respiratory alkalosis | 19.81 | 15.98 | 16 | 35593 | 4295 | 79704484 |
Heparin-induced thrombocytopenia | 19.77 | 15.98 | 23 | 35586 | 9659 | 79699120 |
Mediastinitis | 19.73 | 15.98 | 9 | 35600 | 855 | 79707924 |
Staphylococcus test positive | 19.65 | 15.98 | 19 | 35590 | 6462 | 79702317 |
Dialysis | 19.65 | 15.98 | 32 | 35577 | 18430 | 79690349 |
Chemotherapeutic drug level increased | 19.64 | 15.98 | 7 | 35602 | 350 | 79708429 |
Stenotrophomonas infection | 19.48 | 15.98 | 15 | 35594 | 3758 | 79705021 |
Vomiting | 19.38 | 15.98 | 197 | 35412 | 665631 | 79043148 |
Hypervolaemia | 19.26 | 15.98 | 52 | 35557 | 42638 | 79666141 |
Therapeutic product effect incomplete | 19.12 | 15.98 | 21 | 35588 | 141624 | 79567155 |
Organising pneumonia | 19.10 | 15.98 | 24 | 35585 | 10915 | 79697864 |
Laryngeal inflammation | 19.02 | 15.98 | 6 | 35603 | 205 | 79708574 |
Product contamination microbial | 18.95 | 15.98 | 9 | 35600 | 937 | 79707842 |
Choluria | 18.76 | 15.98 | 7 | 35602 | 399 | 79708380 |
Vertigo | 18.69 | 15.98 | 4 | 35605 | 69078 | 79639701 |
Vascular device infection | 18.67 | 15.98 | 23 | 35586 | 10253 | 79698526 |
Tachypnoea | 18.62 | 15.98 | 43 | 35566 | 32020 | 79676759 |
Flavobacterium infection | 18.49 | 15.98 | 5 | 35604 | 98 | 79708681 |
Coagulopathy | 18.45 | 15.98 | 46 | 35563 | 35960 | 79672819 |
Injection site erythema | 18.36 | 15.98 | 6 | 35603 | 78191 | 79630588 |
Hypertensive heart disease | 18.05 | 15.98 | 15 | 35594 | 4191 | 79704588 |
Blastomycosis | 18.05 | 15.98 | 8 | 35601 | 711 | 79708068 |
Palpitations | 17.96 | 15.98 | 18 | 35591 | 126592 | 79582187 |
Adverse drug reaction | 17.64 | 15.98 | 4 | 35605 | 66388 | 79642391 |
Cerebral haemorrhage | 17.37 | 15.98 | 61 | 35548 | 57612 | 79651167 |
Pulmonary mucormycosis | 17.18 | 15.98 | 9 | 35600 | 1156 | 79707623 |
Pneumonitis | 17.16 | 15.98 | 63 | 35546 | 60797 | 79647982 |
Flushing | 17.14 | 15.98 | 9 | 35600 | 88259 | 79620520 |
Blood lactate dehydrogenase increased | 16.96 | 15.98 | 47 | 35562 | 39123 | 79669656 |
Eye infection fungal | 16.96 | 15.98 | 7 | 35602 | 522 | 79708257 |
Impaired healing | 16.93 | 15.98 | 9 | 35600 | 87646 | 79621133 |
Anaemia | 16.60 | 15.98 | 285 | 35324 | 444730 | 79264049 |
Acute myeloid leukaemia recurrent | 16.49 | 15.98 | 13 | 35596 | 3370 | 79705409 |
Product use issue | 16.47 | 15.98 | 44 | 35565 | 209778 | 79499001 |
Liver disorder | 16.42 | 15.98 | 70 | 35539 | 72347 | 79636432 |
Hypoalbuminaemia | 16.35 | 15.98 | 32 | 35577 | 21265 | 79687514 |
Vision blurred | 16.26 | 15.98 | 14 | 35595 | 105884 | 79602895 |
Hepatosplenic candidiasis | 16.25 | 15.98 | 7 | 35602 | 581 | 79708198 |
Hypercapnia | 16.23 | 15.98 | 20 | 35589 | 8915 | 79699864 |
Lymphatic disorder | 16.21 | 15.98 | 6 | 35603 | 334 | 79708445 |
Posterior reversible encephalopathy syndrome | 16.10 | 15.98 | 36 | 35573 | 26245 | 79682534 |
Arteritis coronary | 16.05 | 15.98 | 4 | 35605 | 56 | 79708723 |
Rectal haemorrhage | 16.00 | 15.98 | 7 | 35602 | 76293 | 79632486 |
Kidney fibrosis | 15.99 | 15.98 | 13 | 35596 | 3522 | 79705257 |
None
Source | Code | Description |
---|---|---|
ATC | J01DE01 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIBACTERIALS FOR SYSTEMIC USE OTHER BETA-LACTAM ANTIBACTERIALS Fourth-generation cephalosporins |
ATC | J01RA06 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIBACTERIALS FOR SYSTEMIC USE COMBINATIONS OF ANTIBACTERIALS Combinations of antibacterials |
FDA CS | M0003827 | Cephalosporins |
FDA EPC | N0000175488 | Cephalosporin Antibacterial |
MeSH PA | D000900 | Anti-Bacterial Agents |
MeSH PA | D000890 | Anti-Infective Agents |
CHEBI has role | CHEBI:36047 | antibacterial drugs |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Infection due to Pseudomonas aeruginosa | indication | 11218009 | |
Pneumonia due to Streptococcus | indication | 34020007 | |
Pneumonia due to Pseudomonas | indication | 41381004 | |
Bacterial pneumonia | indication | 53084003 | DOID:874 |
Klebsiella cystitis | indication | 60867007 | |
Infectious disease of abdomen | indication | 128070006 | |
Bacterial infection due to Klebsiella pneumoniae | indication | 186435004 | |
Bacterial peritonitis | indication | 197171003 | |
Pneumococcal pneumonia | indication | 233607000 | |
Escherichia coli urinary tract infection | indication | 301011002 | |
Proteus urinary tract infection | indication | 301012009 | |
Streptococcus pyogenes infection | indication | 302809008 | |
Bacterial urinary infection | indication | 312124009 | |
Infection due to Staphylococcus aureus | indication | 406602003 | |
Urinary tract infection caused by Klebsiella | indication | 369001000119100 | |
Complicated Proteus UTI | indication | ||
E. Coli Pyelonephritis | indication | ||
Complicated Urinary Tract Infections | indication | ||
Complicated Bacteroides Peritonitis | indication | ||
Complicated Streptococcus Peritonitis | indication | ||
Klebsiella Pyelonephritis | indication | ||
Complicated E. Coli Peritonitis | indication | ||
Enterobacter Pneumonia | indication | ||
Complicated Klebsiella Peritonitis | indication | ||
Proteus Pyelonephritis | indication | ||
Myoclonus | contraindication | 17450006 | |
Colitis | contraindication | 64226004 | DOID:0060180 |
Blood coagulation disorder | contraindication | 64779008 | DOID:1247 |
Factor II deficiency | contraindication | 73975000 | |
Disorder of brain | contraindication | 81308009 | DOID:936 |
Seizure disorder | contraindication | 128613002 | |
Impaired renal function disorder | contraindication | 197663003 | |
Pseudomembranous enterocolitis | contraindication | 397683000 |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 2.32 | acidic |
pKa2 | 13.31 | acidic |
pKa3 | 3.1 | Basic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Bacterial penicillin-binding protein | Enzyme | INHIBITOR | CHEMBL | CHEMBL |
ID | Source |
---|---|
4024049 | VUID |
N0000022054 | NUI |
D01157 | KEGG_DRUG |
123171-59-5 | SECONDARY_CAS_RN |
20481 | RXNORM |
C0055003 | UMLSCUI |
CHEBI:478164 | CHEBI |
9WT | PDB_CHEM_ID |
CHEMBL186 | ChEMBL_ID |
CHEMBL1200962 | ChEMBL_ID |
D000077723 | MESH_DESCRIPTOR_UI |
DB01413 | DRUGBANK_ID |
10772 | IUPHAR_LIGAND_ID |
6092 | INN_ID |
807PW4VQE3 | UNII |
5479537 | PUBCHEM_CID |
116681 | MMSL |
4373 | MMSL |
d03882 | MMSL |
370370003 | SNOMEDCT_US |
370371004 | SNOMEDCT_US |
96048006 | SNOMEDCT_US |
4020908 | VANDF |
4024049 | VANDF |
004974 | NDDF |
004975 | NDDF |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
CEFEPIME HYDROCHLORIDE AND DEXTROSE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0264-3193 | INJECTION, SOLUTION | 1 g | INTRAVENOUS | NDA | 30 sections |
CEFEPIME HYDROCHLORIDE AND DEXTROSE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0264-3193 | INJECTION, SOLUTION | 1 g | INTRAVENOUS | NDA | 30 sections |
CEFEPIME HYDROCHLORIDE AND DEXTROSE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0264-3195 | INJECTION, SOLUTION | 2 g | INTRAVENOUS | NDA | 30 sections |
CEFEPIME HYDROCHLORIDE AND DEXTROSE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0264-3195 | INJECTION, SOLUTION | 2 g | INTRAVENOUS | NDA | 30 sections |
Cefepime | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0338-1301 | INJECTION, SOLUTION | 1 g | INTRAVENOUS | NDA | 28 sections |
Cefepime | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0338-1301 | INJECTION, SOLUTION | 1 g | INTRAVENOUS | NDA | 28 sections |
Cefepime | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0338-1301 | INJECTION, SOLUTION | 1 g | INTRAVENOUS | NDA | 28 sections |
Cefepime | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0338-1301 | INJECTION, SOLUTION | 1 g | INTRAVENOUS | NDA | 28 sections |
Cefepime | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-9566 | INJECTION, POWDER, FOR SOLUTION | 1 g | INTRAVENOUS | ANDA | 27 sections |
Cefepime | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-9566 | INJECTION, POWDER, FOR SOLUTION | 1 g | INTRAVENOUS | ANDA | 27 sections |
Cefepime | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-9735 | INJECTION, POWDER, FOR SOLUTION | 2 g | INTRAVENOUS | ANDA | 27 sections |
Cefepime | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-9735 | INJECTION, POWDER, FOR SOLUTION | 2 g | INTRAVENOUS | ANDA | 27 sections |
Cefepime Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0781-3222 | INJECTION, POWDER, FOR SOLUTION | 1 g | INTRAVENOUS | ANDA | 27 sections |
Cefepime Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0781-3223 | INJECTION, POWDER, FOR SOLUTION | 2 g | INTRAVENOUS | ANDA | 27 sections |
cefepime | HUMAN PRESCRIPTION DRUG LABEL | 1 | 25021-121 | INJECTION, POWDER, FOR SOLUTION | 1 g | INTRAVENOUS | ANDA | 29 sections |
cefepime | HUMAN PRESCRIPTION DRUG LABEL | 1 | 25021-121 | INJECTION, POWDER, FOR SOLUTION | 1 g | INTRAVENOUS | ANDA | 29 sections |
cefepime | HUMAN PRESCRIPTION DRUG LABEL | 1 | 25021-121 | INJECTION, POWDER, FOR SOLUTION | 1 g | INTRAVENOUS | ANDA | 29 sections |
cefepime | HUMAN PRESCRIPTION DRUG LABEL | 1 | 25021-121 | INJECTION, POWDER, FOR SOLUTION | 1 g | INTRAVENOUS | ANDA | 29 sections |
cefepime | HUMAN PRESCRIPTION DRUG LABEL | 1 | 25021-122 | INJECTION, POWDER, FOR SOLUTION | 2 g | INTRAVENOUS | ANDA | 29 sections |
cefepime | HUMAN PRESCRIPTION DRUG LABEL | 1 | 25021-122 | INJECTION, POWDER, FOR SOLUTION | 2 g | INTRAVENOUS | ANDA | 29 sections |
cefepime | HUMAN PRESCRIPTION DRUG LABEL | 1 | 25021-122 | INJECTION, POWDER, FOR SOLUTION | 2 g | INTRAVENOUS | ANDA | 29 sections |
cefepime | HUMAN PRESCRIPTION DRUG LABEL | 1 | 25021-122 | INJECTION, POWDER, FOR SOLUTION | 2 g | INTRAVENOUS | ANDA | 29 sections |
Cefepime | HUMAN PRESCRIPTION DRUG LABEL | 1 | 44567-130 | INJECTION, POWDER, FOR SOLUTION | 1 g | INTRAVENOUS | ANDA | 26 sections |
Cefepime | HUMAN PRESCRIPTION DRUG LABEL | 1 | 44567-131 | INJECTION, POWDER, FOR SOLUTION | 2 g | INTRAVENOUS | ANDA | 26 sections |
Cefepime | HUMAN PRESCRIPTION DRUG LABEL | 1 | 44567-240 | INJECTION, POWDER, FOR SOLUTION | 1 g | INTRAVENOUS | ANDA | 26 sections |
Cefepime | HUMAN PRESCRIPTION DRUG LABEL | 1 | 44567-241 | INJECTION, POWDER, FOR SOLUTION | 2 g | INTRAVENOUS | ANDA | 26 sections |
Cefepime | HUMAN PRESCRIPTION DRUG LABEL | 1 | 60505-6144 | INJECTION, POWDER, FOR SOLUTION | 1 g | INTRAVENOUS | ANDA | 28 sections |
Cefepime | HUMAN PRESCRIPTION DRUG LABEL | 1 | 60505-6144 | INJECTION, POWDER, FOR SOLUTION | 1 g | INTRAVENOUS | ANDA | 28 sections |
Cefepime | HUMAN PRESCRIPTION DRUG LABEL | 1 | 60505-6144 | INJECTION, POWDER, FOR SOLUTION | 1 g | INTRAVENOUS | ANDA | 28 sections |
Cefepime | HUMAN PRESCRIPTION DRUG LABEL | 1 | 60505-6145 | INJECTION, POWDER, FOR SOLUTION | 2 g | INTRAVENOUS | ANDA | 28 sections |