sotagliflozin Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
sodium glucose co-transporter inhibitors, phlorizin derivatives 5339 1018899-04-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • sotagliflozin
  • zynquista
  • LP-802034
  • LX4211
  • LX-4211
Sotagliflozin is a dual inhibitor of sodium glucose cotransporter type 1 (SGLT1) and SGLT2. Local intestinal inhibition of SGLT1, the major transporter for glucose absorption, delays and reduces glucose absorption in the proximal intestine, resulting in a blunting and delay of postprandial hyperglycaemia. SGLT2 is the predominant transporter responsible for reabsorption of glucose from the glomerular filtrate back into the circulation. By inhibiting SGLT2, sotagliflozin reduces renal reabsorption of filtered glucose and lowers the renal threshold for glucose, and thereby increases urinary glucose excretion
  • Molecular weight: 424.94
  • Formula: C21H25ClO5S
  • CLOGP: 3.66
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 3
  • TPSA: 79.15
  • ALOGS: -4.01
  • ROTB: 6

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
April 26, 2019 EMA SANOFI-AVENTIS GROUPE

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
ATC A10BK06 ALIMENTARY TRACT AND METABOLISM
DRUGS USED IN DIABETES
BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS
Sodium-glucose co-transporter 2 (SGLT2) inhibitors
MeSH PA D007004 Hypoglycemic Agents
MeSH PA D000077203 Sodium-Glucose Transporter 2 Inhibitors

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Diabetes mellitus type 1 indication 46635009 DOID:9744

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 12.45 acidic
pKa2 13.37 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Sodium/glucose cotransporter 1 Transporter INHIBITOR IC50 7.44 SCIENTIFIC LITERATURE DRUG LABEL
Sodium/glucose cotransporter 2 Transporter INHIBITOR IC50 8.74 SCIENTIFIC LITERATURE DRUG LABEL

External reference:

IDSource
C3502472 UMLSCUI
CHEMBL3039507 ChEMBL_ID
D10669 KEGG_DRUG
C575681 MESH_SUPPLEMENTAL_RECORD_UI
8312 IUPHAR_LIGAND_ID
9824 INN_ID
DB12713 DRUGBANK_ID
6B4ZBS263Y UNII
24831714 PUBCHEM_CID

Pharmaceutical products:

None