calaspargase pegol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
enzymes	5321	941577-06-6

Description:

Molecule	Description
Synonyms: calaspargase pegol asparlas EZN-2285	L-asparaginase is an enzyme that catalyzes the conversion of the amino acid L-asparagine into aspartic acid and ammonia. The pharmacological effect of ASPARLAS is thought to be based on selective killing of leukemic cells due to depletion of plasma L-asparagine. Leukemic cells with low expression of asparagine synthetase have a reduced ability to synthesize L-asparagine, and therefore depend on an exogenous source of L-asparagine for survival. Molecular weight: Formula: CLOGP: LIPINSKI: None HAC: None HDO: None TPSA: ALOGS: ROTB: None

Molecule

Description

Synonyms:

calaspargase pegol
asparlas
EZN-2285

L-asparaginase is an enzyme that catalyzes the conversion of the amino acid L-asparagine into aspartic acid and ammonia. The pharmacological effect of ASPARLAS is thought to be based on selective killing of leukemic cells due to depletion of plasma L-asparagine. Leukemic cells with low expression of asparagine synthetase have a reduced ability to synthesize L-asparagine, and therefore depend on an exogenous source of L-asparagine for survival.

Molecular weight:
Formula:
CLOGP:
LIPINSKI: None
HAC: None
HDO: None
TPSA:
ALOGS:
ROTB: None

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
Dec. 20, 2018	FDA	SERVIER PHARMA LLC

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
FDA CS	M0001815	Asparaginase
FDA EPC	N0000175669	Asparagine-specific Enzyme

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Acute lymphoblastic leukemia	indication	413440007

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

ID	Source
T9FVH03HMZ	UNII
C2699709	UMLSCUI
CHEMBL2108728	ChEMBL_ID
DB14730	DRUGBANK_ID
D10096	KEGG_DRUG
9250	INN_ID
783683008	SNOMEDCT_US
783687009	SNOMEDCT_US
2121416	RXNORM
303899	MMSL
35900	MMSL
d09115	MMSL
C000595188	MESH_SUPPLEMENTAL_RECORD_UI

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
asparlas	HUMAN PRESCRIPTION DRUG LABEL	1	72694-515	INJECTION, SOLUTION	750 U	INTRAVENOUS	BLA	27 sections
asparlas	HUMAN PRESCRIPTION DRUG LABEL	1	72694-515	INJECTION, SOLUTION	750 U	INTRAVENOUS	BLA	27 sections