elapegademase 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
enzymes	5318	1709806-75-6

Description:

Molecule	Description
Synonyms: elapegademase revcovi EZN-2279 elapegademase-lvlr	Elapegademase-lvlr provides an exogenous source of ADA enzyme that is associated with a decrease in toxic adenosine and deoxyadenosine nucleotides levels as well as an increase in lymphocyte number. Molecular weight: Formula: CLOGP: LIPINSKI: None HAC: None HDO: None TPSA: ALOGS: ROTB: None

Molecule

Description

Synonyms:

elapegademase
revcovi
EZN-2279
elapegademase-lvlr

Elapegademase-lvlr provides an exogenous source of ADA enzyme that is associated with a decrease in toxic adenosine and deoxyadenosine nucleotides levels as well as an increase in lymphocyte number.

Molecular weight:
Formula:
CLOGP:
LIPINSKI: None
HAC: None
HDO: None
TPSA:
ALOGS:
ROTB: None

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
Oct. 5, 2018	FDA	LEADIANT BIOSCI INC
March 26, 2019	PMDA	TEIJIN PHARMA LIMITED

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	L03AX21	ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS IMMUNOSTIMULANTS IMMUNOSTIMULANTS Other immunostimulants
MeSH PA	D058892	Adenosine Deaminase Inhibitors
MeSH PA	D004791	Enzyme Inhibitors

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
SCID due to absent adenosine deaminase	indication	36980009
Adenosine deaminase deficiency	indication	44940001	DOID:5810

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

ID	Source
9R3D3Y0UHS	UNII
C4731737	UMLSCUI
CHEMBL3990026	ChEMBL_ID
121488177	PUBCHEM_CID
DB14712	DRUGBANK_ID
D11017	KEGG_DRUG
10378	INN_ID
017797	NDDF
782147005	SNOMEDCT_US
782152000	SNOMEDCT_US
4038007	VANDF
4038008	VANDF
2059218	RXNORM
294366	MMSL
35316	MMSL
35317	MMSL
d09011	MMSL
C000645732	MESH_SUPPLEMENTAL_RECORD_UI

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Revcovi	HUMAN PRESCRIPTION DRUG LABEL	1	10122-502	INJECTION	1.60 mg	INTRAMUSCULAR	BLA	27 sections
Revcovi	HUMAN PRESCRIPTION DRUG LABEL	1	10122-502	INJECTION	1.60 mg	INTRAMUSCULAR	BLA	27 sections
Revcovi	HUMAN PRESCRIPTION DRUG LABEL	1	57665-002	INJECTION	1.60 mg	INTRAMUSCULAR	BLA	27 sections
Revcovi	HUMAN PRESCRIPTION DRUG LABEL	1	57665-002	INJECTION	1.60 mg	INTRAMUSCULAR	BLA	27 sections