pegademase 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
enzymes	5206	130167-68-9

Description:

Molecule	Description
Synonyms: pegademase pegademase bovine adagen	Pegademase bovine is a modified enzyme used for enzyme replacement therapy for the treatment of severe combined immunodeficiency disease (SCID) associated with a deficiency of adenosine deaminase. In the absence of the ADA enzyme, the purine substrates adenosine and 2'-deoxyadenosine accumulate, causing metabolic abnormalities that are directly toxic to lymphocytes. Molecular weight: Formula: CLOGP: LIPINSKI: None HAC: None HDO: None TPSA: ALOGS: ROTB: None

Molecule

Description

Synonyms:

pegademase
pegademase bovine
adagen

Pegademase bovine is a modified enzyme used for enzyme replacement therapy for the treatment of severe combined immunodeficiency disease (SCID) associated with a deficiency of adenosine deaminase. In the absence of the ADA enzyme, the purine substrates adenosine and 2'-deoxyadenosine accumulate, causing metabolic abnormalities that are directly toxic to lymphocytes.

Molecular weight:
Formula:
CLOGP:
LIPINSKI: None
HAC: None
HDO: None
TPSA:
ALOGS:
ROTB: None

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
March 21, 1990	FDA	SIGMA TAU

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Dermatofibrosarcoma protuberans	93.82	44.38	7	4	36	79744341

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	L03AX04	ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS IMMUNOSTIMULANTS IMMUNOSTIMULANTS Other immunostimulants
FDA CS	M0000379	Adenosine Deaminase
FDA EPC	N0000175471	Bovine Intestinal Adenosine Deaminase

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Adenosine deaminase deficiency	indication	44940001	DOID:5810

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

ID	Source
4020328	VANDF
C0164674	UMLSCUI
CHEMBL1201703	ChEMBL_ID
DB00061	DRUGBANK_ID
D05384	KEGG_DRUG
CHEMBL1201514	ChEMBL_ID
C051409	MESH_SUPPLEMENTAL_RECORD_UI
5238	MMSL
996	MMSL
d01180	MMSL
003552	NDDF
108743002	SNOMEDCT_US
411097008	SNOMEDCT_US
215019	RXNORM
HW3H7D91F6	UNII

Pharmaceutical products:

None