vibegron Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
beta3-adrenoreceptor agonists 5311 1190389-15-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • vibegron
  • beova
  • MK-4618
  • RVT-901
  • KRP-114V
Vibegron is selectively binds to the beta 3 adrenergic receptor (beta3 AR) in bladder smooth muscle, resulting in relaxation of the detrusor muscle.
  • Molecular weight: 444.54
  • Formula: C26H28N4O3
  • CLOGP: 1.87
  • LIPINSKI: 0
  • HAC: 7
  • HDO: 3
  • TPSA: 94.03
  • ALOGS: -4.05
  • ROTB: 6

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Sept. 21, 2018 PMDA Kyorin Pharmaceutical Co., Ltd.

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
CHEBI has role CHEBI:35522 beta-adrenergic agonist

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Bladder muscle dysfunction - overactive indication 236633002

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 13.78 acidic
pKa2 8.94 Basic
pKa3 2.54 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Beta-3 adrenergic receptor GPCR AGONIST EC50 8.96 SCIENTIFIC LITERATURE SCIENTIFIC LITERATURE

External reference:

IDSource
44472635 PUBCHEM_CID
CHEBI:142418 CHEBI
M5TSE03W5U UNII
9676 INN_ID
D10433 KEGG_DRUG
DB14895 DRUGBANK_ID
CHEMBL2107826 ChEMBL_ID
10100 IUPHAR_LIGAND_ID
C000608232 MESH_SUPPLEMENTAL_RECORD_UI

Pharmaceutical products:

None