Molfile
Inchi
Smiles
Synonyms:
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tecovirimat
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tpoxx
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siga-246
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ST-246
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tecovirimat monohydrate
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Tecovirimat targets and inhibits the activity of the orthopoxvirus VP37 protein (encoded by and highly conserved in all members of the orthopoxvirus genus) and blocks its interaction with cellular Rab9 GTPase and TIP47, which prevents the formation of egress-competent enveloped virions necessary for cell-to-cell and long-range dissemination of virus.
- Molecular weight: 376.34
- Formula: C19H15F3N2O3
- CLOGP: 2.94
- LIPINSKI: 0
- HAC: 5
- HDO: 1
- TPSA: 66.48
- ALOGS: -4.25
- ROTB: 3
- Status: ONP
Legend: OFP - off patent OFM - off market ONP - on patent
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