cefamandole nafate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
antibiotics, cefalosporanic acid derivatives	528	42540-40-9

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

cefamandole nafate
cefamandole formate sodium
cephamandole nafate
kefadol
kefandol
lampomandol
neocefal

Molecular weight: 490.51
Formula: C19H18N6O6S2
CLOGP: 0.24
LIPINSKI: 1
HAC: 12
HDO: 2
TPSA: 156.61
ALOGS: -3.33
ROTB: 9

Status: OFM

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

None

ADMET properties:

Property	Value	Reference
S (Water solubility)	100 mg/mL	Bocci G, Oprea TI, Benet LZ
BDDCS (Biopharmaceutical Drug Disposition Classification System)	3	Bocci G, Oprea TI, Benet LZ

Approvals:

Date	Agency	Company	Orphan
Sept. 27, 1978	FDA	LILLY

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
CHEBI has role	CHEBI:36047	antibacterial drugs
CHEBI has role	CHEBI:50266	Prodrugs
MeSH PA	D000900	Anti-Bacterial Agents
MeSH PA	D000890	Anti-Infective Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	2.63	acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Bacterial penicillin-binding protein	Enzyme		PBPA_ECOLI PBPB_ECOLI DACC_ECOLI PBP2_ECOLI FTSI_ECOLI DACA_ECOLI DACB_ECOLI	INHIBITOR				CHEMBL	CHEMBL

External reference:

ID	Source
4017539	VUID
N0000179072	NUI
D00909	KEGG_DRUG
203480	RXNORM
C0054995	UMLSCUI
CHEBI:3481	CHEBI
CHEMBL1201218	ChEMBL_ID
CHEMBL1618	ChEMBL_ID
DB14725	DRUGBANK_ID
C012810	MESH_SUPPLEMENTAL_RECORD_UI
8HDO7941DO	UNII
23665731	PUBCHEM_CID
4370	MMSL
8100	MMSL
48172009	SNOMEDCT_US
4017539	VANDF
002725	NDDF

Pharmaceutical products:

None