moxidectin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
antiparasitics, ivermectin derivatives 5286 113507-06-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • moxidectin
The mechanism by which moxidectin exhibits its effect against O. volvulus is not known. Studies with other nematodes suggest that moxidectin binds to glutamate-gated chloride channels (GluCl), gamma-aminobutyric acid (GABA) receptors and/or ATP-binding cassette (ABC) transporters. This leads to increased permeability, influx of chloride ions, hyperpolarization and muscle paralysis. Additionally, there is a reduction in motility of all stages of the parasite, excretion of immunomodulatory proteins, and the fertility of both male and female adult worms.
  • Molecular weight: 639.83
  • Formula: C37H53NO8
  • CLOGP: 6
  • LIPINSKI: 2
  • HAC: 9
  • HDO: 2
  • TPSA: 116.04
  • ALOGS: -5.09
  • ROTB: 3

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

PropertyValueReference
S (Water solubility) 0.00 mg/mL Bocci G, Oprea TI, Benet LZ
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Bocci G, Oprea TI, Benet LZ

Approvals:

DateAgencyCompanyOrphan
June 13, 2018 FDA MDGH

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC P02CX03 ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTS
ANTHELMINTICS
ANTINEMATODAL AGENTS
Other antinematodals
MeSH PA D000871 Anthelmintics
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000969 Antinematodal Agents
MeSH PA D000977 Antiparasitic Agents
MeSH PA D007306 Insecticides
MeSH PA D010575 Pesticides

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Infection by Onchocerca volvulus indication 38539003 DOID:11678




🐶 Veterinary Drug Use

SpeciesUseRelation
Cats Prevention of heartworm disease caused by Dirofilaria immitis Indication
Cats Ear mite infestations with Otodectes cynotis Indication
Cats Treatment and control of intestinal roundworms, Toxocara cati Indication
Cats Treatment and control of hookworms, Ancylostoma tubaeforme Indication
Cattle Treatment and control of gastrointestinal roundworms, Ostertagia ostertagi (adult and L4, including inhibited larvae) Indication
Cattle Treatment and control of gastrointestinal roundworms, Haemonchus placei (adult and L4) Indication
Cattle Treatment and control of gastrointestinal roundworms, Trichostrongylus axei (adult and L4) Indication
Cattle Treatment and control of gastrointestinal roundworms, T colubriformis (adult and L4) Indication
Cattle Treatment and control of gastrointestinal roundworms, Cooperia oncophora (adult and L4) Indication
Cattle Treatment and control of gastrointestinal roundworms, C pectinata (adult) Indication
Cattle Treatment and control of gastrointestinal roundworms, C punctata (adult and L4) Indication
Cattle Treatment and control of gastrointestinal roundworms, C spatulata (adult) Indication
Cattle Treatment and control of gastrointestinal roundworms, C surnabada (adult and L4) Indication
Cattle Treatment and control of gastrointestinal roundworms, Bunostomum phlebotomum (adult) Indication
Cattle Treatment and control of gastrointestinal roundworms, Oesophagostomum radiatum (adult and L4) Indication
Cattle Treatment and control of gastrointestinal roundworms, Nematodirus helvetianus (adult and L4) Indication
Cattle Treatment and control of lungworms, Dictyocaulus viviparus, (adult and L4) Indication
Cattle Treatment and control of grubs, Hypoderma bovis Indication
Cattle Treatment and control of mites, Chorioptes bovis Indication
Cattle Treatment and control of mites, Psoroptes ovis (P communis var bovis)) Indication
Cattle Treatment and control of lice, Linognathus vituli Indication
Cattle Treatment and control of lice, Haematopinus eurysternus Indication
Cattle Treatment and control of lice, Solenopotes capillatus Indication
Cattle Treatment and control of lice, Bovicola bovis Indication
Cattle Treatment and control of horn flies, Haematobia irritans Indication
Cattle Protection (14 days) from reinfection with H placei Indication
Cattle Protection (28 days) from reinfection with O radiatum Indication
Cattle Protection (42 days) from reinfection with D viviparus Indication
Cattle Protection (28 days) from reinfection with O ostertagi Indication
Cattle Treatment and control of grubs, H lineatum Indication
Dogs Treatment of infections with hookworm, Ancylostoma caninum Indication
Dogs Prevents infection by heartworm Dirofilaria immitis Indication
Dogs Treatment of infections with hookworm, Unicinaria stenocephala Indication
Ferrets Prevention of heartworm disease caused by Dirofilaria immitis Indication
Horses Treatment and control of Large Strongyles, Strongylus vulgaris (adults and L4 / L5 arterial stages) Indication
Horses Treatment and control of Large Strongyles, Strongylus edentatus (adults and tissue stages) Indication
Horses Treatment and control of Large Strongyles, Triodontophorus brevicauda (adults) Indication
Horses Treatment and control of Large Strongyles,Triodontophorus serratus (adults) Indication
Horses Treatment and control of Small Strongyles, Cyathostomum catinatum Indication
Horses Treatment and control of Small Strongyles, Cyathostomum pateratum Indication
Horses Treatment and control of Small Strongyles, Cylicostephanus calicatus Indication
Horses Treatment and control of Small Strongyles, Cylicostephanus goldi Indication
Horses Treatment and control of Small Strongyles, Cylicostephanus longibursatus Indication
Horses Treatment and control of Small Strongyles, Cylicostephanus minutus Indication
Horses Treatment and control of Small Strongyles, including Cylicocyclus insigne Indication
Horses Treatment and control of Small Strongyles, Cylicocyclus leptostomum Indication
Horses Treatment and control of Small Strongyles, Cylicocyclus nassatus Indication
Horses Treatment and control of Small Strongyles, Cylicocyclus radiatusm Indication
Horses Treatment and control of Small Strongyles, Coronocyclus coronatus Indication
Horses Treatment and control of Small Strongyles, Coronocyclus labiatus Indication
Horses Treatment and control of Small Strongyles, Coronocyclus labratus Indication
Horses Treatment and control of Small Strongyles, Gyalocephalus capitatus Indication
Horses Treatment and control of Small Strongyles, Petrovinema poculatus Indication
Horses Treatment and control of Small Strongyles, undifferentiated lumenal larvae Indication
Horses Treatment and control of Encysted cyathostomes (Late L3 and L4, mucosal cyathostome larvae) Indication
Horses Treatment and control of Ascarids Parascaris equorum (adults and L4 larval stages) Indication
Horses Treatment and control of Pinworms, Oxyuris equi (adults and L4 larval stages) Indication
Horses Treatment and control of Hairworms, Trichostrongylus axei (adults) Indication
Horses Treatment and control of Large-mouth stomach worms, Habronema muscae (adults) Indication
Horses Treatment and control of Stomach bots, Gasterophilus intestinalis (2nd and 3rd instars) Indication
Horses Treatment and control of Gasterophilus nasalis (3rd instars) Indication
Horses Suppresses strongyle egg production Indication
Sheep Treatment and control of the adult and L4 larval stages of Haemonchus contortus Indication
Sheep Treatment and control of the adult and L4 larval stages of Teladorsagia circumcincta Indication
Sheep Treatment and control of the adult and L4 larval stages of T trifurcate Indication
Sheep Treatment and control of the gastrointestinal roundworms, Trichostrongylus axei (Adults and fourth-stage larvae) Indication
Sheep Treatment and control of the adult and L4 larval stages of T colubriformis Indication
Sheep Treatment and control of the adult and L4 larval stages of T vitrines Indication
Sheep Treatment and control of the adult and L4 larval stages of Cooperia curticei Indication
Sheep Treatment and control of the adult and L4 larval stages of C oncophora Indication
Sheep Treatment and control of the adult and L4 larval stages of Oesophagostomum columbianum Indication
Sheep Treatment and control of the adult and L4 larval stages of O venulosum Indication
Sheep Treatment and control of the adult and L4 larval stages of Nematodirus battus Indication
Sheep Treatment and control of the adult and L4 larval stages of N filicollis Indication
Sheep Treatment and control of the adult and L4 larval stages of N spathiger Indication

🐶 Veterinary products

ProductApplicantIngredients
ProHeart Zoetis Inc. 1
Quest Gel Zoetis Inc. 1
Cydectin (moxidectin) Pour-On for Beef and Dairy Cattle Elanco US Inc. 1
ProHeart 6 Zoetis Inc. 1
Quest Plus Gel Zoetis Inc. 2
Cydectin Elanco US Inc. 1
Cydectin Oral Drench for Sheep Elanco US Inc. 1
Advantage Multi for Dogs Elanco US Inc. 2
Advantage Multi for Cats Elanco US Inc. 2
CORAXIS Elanco US Inc. 1
BRAVECTO PLUS Intervet Inc. 2
ProHeart 12 Zoetis Inc. 1
Simparica Trio Zoetis Inc. 3
IMOXI Topical Solution for Dogs Vetoquinol USA Inc. 2
IMOXI Topical Solution for Cats Vetoquinol USA Inc. 2
PARASEDGE Multi for Dogs Chanelle Pharmaceuticals Manufacturing Ltd. 2
PARASEDGE Multi for Cats Chanelle Pharmaceuticals Manufacturing Ltd. 2
Barrier for cats Aurora Pharmaceutical Inc. 2
Midamox for Dogs Norbrook Laboratories, Ltd. 2
Barrier for dogs Aurora Pharmaceutical Inc. 2
Midamox for Cats Norbrook Laboratories, Ltd. 2

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 12.24 acidic
pKa2 13.33 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRouteExclusivity dateDescription
2MG MOXIDECTIN MDGH N210867 June 13, 2018 RX TABLET ORAL June 13, 2023 NEW CHEMICAL ENTITY
2MG MOXIDECTIN MDGH N210867 June 13, 2018 RX TABLET ORAL June 13, 2025 INDICATED FOR THE TREATMENT OF ONCHOCERCIASIS DUE TO ONCHOCERCA VOLVULUS IN PATIENTS AGED 12 YEARS AND OLDER

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Glutamate-gated chloride channel Ion channel INHIBITOR UNKNOWN SCIENTIFIC LITERATURE

External reference:

IDSource
NGU5H31YO9 UNII
C0163557 UMLSCUI
CHEMBL2104415 ChEMBL_ID
9832912 PUBCHEM_CID
DB11431 DRUGBANK_ID
D05084 KEGG_DRUG
6400 INN_ID
017593 NDDF
781257003 SNOMEDCT_US
781277005 SNOMEDCT_US
1047072 RXNORM
C027837 MESH_SUPPLEMENTAL_RECORD_UI

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Moxidectin HUMAN PRESCRIPTION DRUG LABEL 1 71705-050 TABLET 2 mg ORAL NDA 26 sections