erenumab 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
human origin	5284	1582205-90-0

Description:

Molecule	Description
Molfile Synonyms: erenumab erenumab-aooe aimovig AMG 334 AMG-334 erenumab (genetical recombination)	Erenumab-aooe is a human monoclonal antibody that binds to the calcitonin gene-related peptide (CGRP) receptor and antagonizes CGRP receptor function. Molecular weight: Formula: CLOGP: LIPINSKI: None HAC: None HDO: None TPSA: ALOGS: ROTB: None

Molecule

Description

Molfile

Synonyms:

erenumab
erenumab-aooe
aimovig
AMG 334
AMG-334
erenumab (genetical recombination)

Erenumab-aooe is a human monoclonal antibody that binds to the calcitonin gene-related peptide (CGRP) receptor and antagonizes CGRP receptor function.

Molecular weight:
Formula:
CLOGP:
LIPINSKI: None
HAC: None
HDO: None
TPSA:
ALOGS:
ROTB: None

Drug dosage:

Dose	Unit	Route
2.50	mg	P

ADMET properties:

None

Approvals:

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Date	Agency	Company
July 26, 2018	EMA	NOVARTIS EUROPHARM LIMITED
June 23, 2021	PMDA	AMGEN K.K.
May 17, 2018	FDA	AMGEN INC

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FDA Adverse Event Reporting System (Female)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Accidental exposure to product	15147.05	23.01	3548	40762	23857	63420855
Wrong technique in product usage process	13260.81	23.01	3771	40539	58569	63386143
Device difficult to use	8339.54	23.01	1901	42409	10895	63433817
Drug dose omission by device	3410.33	23.01	767	43543	4034	63440678
Device issue	2472.72	23.01	838	43472	22943	63421769
Injection site pain	1781.44	23.01	1113	43197	128687	63316025
Incorrect dose administered by device	1547.60	23.01	398	43912	3950	63440762
Product storage error	1502.25	23.01	514	43796	14442	63430270
Device use error	1455.02	23.01	402	43908	5359	63439353
Constipation	1371.13	23.01	1181	43129	223762	63220950

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FDA Adverse Event Reporting System (Male)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Accidental exposure to product	3067.39	49.06	631	4608	12171	34939521
Wrong technique in product usage process	1887.28	49.06	520	4719	35466	34916226
Device difficult to use	1142.72	49.06	218	5021	2679	34949013
Device issue	447.16	49.06	128	5111	9649	34942043
Drug dose omission by device	431.24	49.06	93	5146	2146	34949546
Occupational exposure to product	386.86	49.06	64	5175	311	34951381
Incorrect dose administered by device	334.32	49.06	73	5166	1785	34949907
Product storage error	312.28	49.06	93	5146	8029	34943663
Injection site haemorrhage	258.29	49.06	84	5155	9684	34942008
Migraine	238.80	49.06	92	5147	17386	34934306

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FDA Adverse Event Reporting System (Geriatric)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Accidental exposure to product	16392.16	27.89	3675	38119	27647	79674947
Wrong technique in product usage process	15125.66	27.89	4072	37722	69803	79632791
Device difficult to use	8838.70	27.89	1908	39886	11477	79691117
Drug dose omission by device	3686.77	27.89	814	40980	5436	79697158
Device issue	2915.93	27.89	914	40880	26194	79676400
Injection site pain	1955.46	27.89	1069	40725	128769	79573825
Incorrect dose administered by device	1845.89	27.89	445	41349	4544	79698050
Device use error	1618.24	27.89	430	41364	6671	79695923
Injection site haemorrhage	1566.36	27.89	578	41216	27292	79675302
Product storage error	1499.56	27.89	488	41306	15738	79686856

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FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

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Source	Code	Description
ATC	N02CD01	NERVOUS SYSTEM ANALGESICS ANTIMIGRAINE PREPARATIONS Calcitonin gene-related peptide (CGRP) antagonists
MeSH PA	D000700	Analgesics
MeSH PA	D000077221	Calcitonin Gene-Related Peptide Receptor Antagonists
MeSH PA	D002491	Central Nervous System Agents
MeSH PA	D018373	Peripheral Nervous System Agents
MeSH PA	D018689	Sensory System Agents

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Drug Use | Suggest Off label Use Form| |View source of the data|

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Disease	Relation	SNOMED_ID	DOID
Migraine	indication	37796009	DOID:6364
Prevention of migraine attacks	indication	408381007

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🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Calcitonin-gene-related peptide receptor	GPCR	O60894 Q16602	RAMP1_HUMAN CALRL_HUMAN	ANTIBODY BINDING	Ki	10.70		SCIENTIFIC LITERATURE	DRUG LABEL

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External reference:

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ID	Source
017547	NDDF
10296	INN_ID
2045613	RXNORM
279240	MMSL
34247	MMSL
34248	MMSL
4037572	VANDF
771590007	SNOMEDCT_US
771675000	SNOMEDCT_US
9250	IUPHAR_LIGAND_ID

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Pharmaceutical products:

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Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
AIMOVIG	HUMAN PRESCRIPTION DRUG LABEL	1	55513-840	INJECTION	70 mg	SUBCUTANEOUS	BLA	30 sections
AIMOVIG	HUMAN PRESCRIPTION DRUG LABEL	1	55513-840	INJECTION	70 mg	SUBCUTANEOUS	BLA	30 sections
AIMOVIG	HUMAN PRESCRIPTION DRUG LABEL	1	55513-840	INJECTION	70 mg	SUBCUTANEOUS	BLA	30 sections
AIMOVIG	HUMAN PRESCRIPTION DRUG LABEL	1	55513-840	INJECTION	70 mg	SUBCUTANEOUS	BLA	30 sections
AIMOVIG	HUMAN PRESCRIPTION DRUG LABEL	1	55513-841	INJECTION	70 mg	SUBCUTANEOUS	BLA	30 sections
AIMOVIG	HUMAN PRESCRIPTION DRUG LABEL	1	55513-841	INJECTION	70 mg	SUBCUTANEOUS	BLA	30 sections
AIMOVIG	HUMAN PRESCRIPTION DRUG LABEL	1	55513-841	INJECTION	70 mg	SUBCUTANEOUS	BLA	30 sections
AIMOVIG	HUMAN PRESCRIPTION DRUG LABEL	1	55513-841	INJECTION	70 mg	SUBCUTANEOUS	BLA	30 sections
AIMOVIG	HUMAN PRESCRIPTION DRUG LABEL	1	55513-842	INJECTION, SOLUTION	140 mg	SUBCUTANEOUS	BLA	30 sections
AIMOVIG	HUMAN PRESCRIPTION DRUG LABEL	1	55513-842	INJECTION, SOLUTION	140 mg	SUBCUTANEOUS	BLA	30 sections

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