All FDA-approved EMA-approved PMDA-approved
Target Card Uniprot Example: P23975

erenumab 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
human origin	5284	1582205-90-0

Description:

Molecule	Description
Molfile Synonyms: erenumab erenumab-aooe aimovig AMG 334 AMG-334 erenumab (genetical recombination)	Erenumab-aooe is a human monoclonal antibody that binds to the calcitonin gene-related peptide (CGRP) receptor and antagonizes CGRP receptor function. Molecular weight: Formula: CLOGP: LIPINSKI: None HAC: None HDO: None TPSA: ALOGS: ROTB: None

Drug dosage:

Dose	Unit	Route
2.50	mg	P

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
July 26, 2018	EMA	NOVARTIS EUROPHARM LIMITED
May 17, 2018	FDA	AMGEN INC
June 23, 2021	PMDA	AMGEN K.K.

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Accidental exposure to product	15147.05	23.01	3548	40762	23857	63420855
Wrong technique in product usage process	13260.81	23.01	3771	40539	58569	63386143
Device difficult to use	8339.54	23.01	1901	42409	10895	63433817
Drug dose omission by device	3410.33	23.01	767	43543	4034	63440678
Device issue	2472.72	23.01	838	43472	22943	63421769
Injection site pain	1781.44	23.01	1113	43197	128687	63316025
Incorrect dose administered by device	1547.60	23.01	398	43912	3950	63440762
Product storage error	1502.25	23.01	514	43796	14442	63430270
Device use error	1455.02	23.01	402	43908	5359	63439353
Constipation	1371.13	23.01	1181	43129	223762	63220950
Injection site haemorrhage	1320.85	23.01	532	43778	23782	63420930
Occupational exposure to product	901.90	23.01	223	44087	1855	63442857
Migraine	787.17	23.01	619	43691	102727	63341985
Underdose	766.81	23.01	377	43933	27079	63417633
Device malfunction	745.15	23.01	324	43986	17533	63427179
Injury associated with device	687.89	23.01	203	44107	3463	63441249
Incorrect disposal of product	662.77	23.01	141	44169	538	63444174
Incorrect dose administered	657.77	23.01	448	43862	59520	63385192
Therapeutic response shortened	634.33	23.01	257	44053	11631	63433081
Therapeutic product effect incomplete	614.23	23.01	583	43727	124473	63320239
Wrong technique in device usage process	482.67	23.01	154	44156	3444	63441268
Injection site bruising	447.23	23.01	308	44002	41602	63403110
Needle issue	279.13	23.01	139	44171	10237	63434475
Injection site swelling	278.38	23.01	245	44065	47327	63397385
Device defective	275.64	23.01	87	44223	1875	63442837
Intercepted product administration error	274.88	23.01	62	44248	328	63444384
Product communication issue	260.33	23.01	66	44244	613	63444099
Injection site indentation	237.38	23.01	49	44261	155	63444557
Injection site erythema	205.13	23.01	271	44039	82903	63361809
Blepharospasm	193.50	23.01	91	44219	5905	63438807
Headache	153.12	23.01	855	43455	632386	62812326
Condition aggravated	152.14	23.01	46	44264	402171	63042541
Anaemia	145.88	23.01	17	44293	293413	63151299
Acute kidney injury	145.07	23.01	10	44300	263405	63181307
Toxicity to various agents	143.44	23.01	7	44303	247243	63197469
Injection site urticaria	141.97	23.01	100	44210	13973	63430739
Pneumonia	140.35	23.01	72	44238	456695	62988017
Taste disorder	123.90	23.01	91	44219	13571	63431141
Muscle spasms	110.14	23.01	297	44013	155853	63288859
Joint swelling	109.29	23.01	46	44264	327620	63117092
Incorrect dose administered by product	109.29	23.01	26	44284	180	63444532
Diarrhoea	108.35	23.01	210	44100	715156	62729556
Neutropenia	108.18	23.01	3	44307	175002	63269710
Arthropathy	106.35	23.01	18	44292	234774	63209938
Pyrexia	105.36	23.01	104	44206	470374	62974338
Product administered at inappropriate site	105.34	23.01	49	44261	3100	63441612
Product dose omission issue	104.47	23.01	380	43930	233933	63210779
Infusion related reaction	102.41	23.01	23	44287	245498	63199214
Neovascularisation	101.89	23.01	36	44274	1109	63443603
General physical health deterioration	96.80	23.01	13	44297	201389	63243323
Infection	96.53	23.01	21	44289	229152	63215560
Injection site extravasation	94.26	23.01	65	44245	8776	63435936
Pemphigus	92.87	23.01	10	44300	183716	63260996
Synovitis	92.41	23.01	11	44299	186907	63257805
Epilepsy	90.67	23.01	103	44207	26962	63417750
Inappropriate schedule of product administration	84.88	23.01	209	44101	103756	63340956
Rheumatoid arthritis	84.01	23.01	36	44274	253783	63190929
Therapy non-responder	83.70	23.01	172	44138	75729	63368983
Injection site rash	83.25	23.01	83	44227	18726	63425986
Completed suicide	81.71	23.01	5	44305	145668	63299044
Oedema peripheral	80.54	23.01	17	44293	189494	63255218
Exposure during pregnancy	79.81	23.01	8	44302	155539	63289173
Injection site pruritus	78.93	23.01	125	44185	44991	63399721
Systemic lupus erythematosus	78.67	23.01	24	44286	208894	63235818
Glossodynia	78.19	23.01	15	44295	178861	63265851
Swelling	77.84	23.01	48	44262	275330	63169382
Urinary tract infection	77.83	23.01	44	44266	264640	63180072
Hand deformity	74.95	23.01	11	44299	159446	63285266
Drug ineffective for unapproved indication	71.86	23.01	103	44207	33960	63410752
Wound	70.70	23.01	14	44296	163249	63281463
Migraine with aura	68.67	23.01	35	44275	2705	63442007
Device failure	65.99	23.01	45	44265	5966	63438746
Fall	64.72	23.01	109	44201	392225	63052487
Dyspnoea	64.50	23.01	241	44069	661072	62783640
White blood cell count decreased	64.44	23.01	10	44300	139094	63305618
Product supply issue	64.00	23.01	29	44281	1726	63442986
Hyponatraemia	62.27	23.01	4	44306	111896	63332816
Hepatic enzyme increased	61.84	23.01	32	44278	202296	63242416
Incorrect route of product administration	60.85	23.01	85	44225	27367	63417345
Abdominal discomfort	60.81	23.01	81	44229	320804	63123908
Paradoxical drug reaction	60.15	23.01	37	44273	4115	63440597
Death	59.93	23.01	106	44204	374275	63070437
Stomatitis	59.85	23.01	12	44298	138713	63305999
Pericarditis	59.73	23.01	10	44300	131569	63313143
Drug hypersensitivity	59.30	23.01	78	44232	310609	63134103
Hypotension	58.93	23.01	62	44248	272542	63172170
Drug interaction	58.01	23.01	45	44265	229086	63215626
Renal failure	57.94	23.01	7	44303	117645	63327067
Product packaging issue	57.26	23.01	24	44286	1182	63443530
Sepsis	56.89	23.01	18	44292	153105	63291607
Rubber sensitivity	56.17	23.01	29	44281	2302	63442410
Dehydration	55.11	23.01	26	44284	173328	63271384
Feeling abnormal	54.88	23.01	227	44083	148165	63296547
Product dispensing error	54.17	23.01	50	44260	10255	63434457
Hypokalaemia	54.13	23.01	5	44305	103799	63340913
Alanine aminotransferase increased	54.11	23.01	5	44305	103765	63340947
Overdose	53.92	23.01	8	44302	115070	63329642
Fear of injection	52.40	23.01	42	44268	7122	63437590
Contraindicated product administered	52.28	23.01	45	44265	217603	63227109
Injection site injury	51.97	23.01	19	44291	647	63444065
Therapeutic product effect decreased	51.83	23.01	269	44041	192918	63251794
Aspartate aminotransferase increased	50.91	23.01	3	44307	90274	63354438
Confusional state	50.81	23.01	54	44256	236326	63208386
Arthralgia	50.80	23.01	215	44095	569495	62875217
Atrial fibrillation	50.49	23.01	10	44300	116626	63328086
Injection site reaction	50.24	23.01	120	44190	58404	63386308
Renal impairment	49.63	23.01	3	44307	88352	63356360
Injection site mass	49.38	23.01	63	44247	18593	63426119
Anti-cyclic citrullinated peptide antibody positive	48.19	23.01	11	44299	116201	63328511
Liquid product physical issue	47.81	23.01	21	44289	1161	63443551
Rheumatoid factor positive	47.01	23.01	3	44307	84403	63360309
Lower respiratory tract infection	46.64	23.01	17	44293	132290	63312422
Asthenia	46.24	23.01	127	44183	383477	63061235
Cardiac failure	44.65	23.01	5	44305	89137	63355575
Memory impairment	44.60	23.01	167	44143	104091	63340621
Paraesthesia	44.49	23.01	222	44088	156744	63287968
Blood creatinine increased	43.81	23.01	5	44305	87839	63356873
Respiratory failure	43.53	23.01	9	44301	101849	63342863
Injection site discolouration	43.05	23.01	39	44271	7809	63436903
Intentional product use issue	42.49	23.01	18	44292	127874	63316838
Rash	41.06	23.01	227	44083	560644	62884068
Musculoskeletal stiffness	40.99	23.01	41	44269	184577	63260135
Blood pressure measurement	40.84	23.01	13	44297	288	63444424
Pain	40.58	23.01	327	43983	740301	62704411
Blister	40.44	23.01	20	44290	129794	63314918
Intentional overdose	40.24	23.01	3	44307	74149	63370563
Circumstance or information capable of leading to medication error	40.19	23.01	28	44282	3842	63440870
Helicobacter infection	40.06	23.01	8	44302	92777	63351935
Leukopenia	39.56	23.01	4	44306	77286	63367426
Hemiplegic migraine	39.52	23.01	10	44300	92	63444620
Hypoaesthesia	39.44	23.01	226	44084	168167	63276545
Post-traumatic neck syndrome	39.32	23.01	22	44288	2052	63442660
Libido increased	39.09	23.01	19	44291	1326	63443386
Treatment failure	38.95	23.01	49	44261	198994	63245718
Device delivery system issue	38.86	23.01	16	44294	753	63443959
Injection site discomfort	37.88	23.01	29	44281	4601	63440111
Concussion	37.63	23.01	39	44271	9205	63435507
Duodenal ulcer perforation	36.66	23.01	8	44302	87201	63357511
Drug abuse	36.48	23.01	4	44306	72514	63372198
Cellulitis	35.52	23.01	7	44303	81951	63362761
Oxygen saturation decreased	35.51	23.01	9	44301	88576	63356136
C-reactive protein increased	35.41	23.01	11	44299	94696	63350016
Soft tissue injury	35.40	23.01	19	44291	1633	63443079
Peripheral swelling	35.13	23.01	84	44226	265858	63178854
Product preparation error	34.85	23.01	31	44279	6061	63438651
Back pain	34.44	23.01	84	44226	264061	63180651
Decreased appetite	34.20	23.01	78	44232	250974	63193738
Hostility	33.18	23.01	19	44291	1853	63442859
Gastrointestinal haemorrhage	33.02	23.01	8	44302	81168	63363544
Cardiac arrest	32.42	23.01	12	44298	92533	63352179
Myocardial oedema	32.28	23.01	10	44300	202	63444510
Heart rate	31.98	23.01	8	44302	70	63444642
Head discomfort	31.93	23.01	43	44267	13372	63431340
Alopecia	31.48	23.01	367	43943	337169	63107543
Therapeutic product effect delayed	31.35	23.01	20	44290	2371	63442341
Coma	31.27	23.01	4	44306	64360	63380352
Medication overuse headache	31.14	23.01	14	44296	818	63443894
Gait disturbance	30.97	23.01	50	44260	183128	63261584
Hypoxia	30.85	23.01	3	44307	59789	63384923
Vertigo	30.84	23.01	102	44208	59785	63384927
Device leakage	30.82	23.01	31	44279	7065	63437647
Septic shock	30.37	23.01	5	44305	66624	63378088
Impaired healing	30.16	23.01	17	44293	102525	63342187
Sternal fracture	29.91	23.01	19	44291	2235	63442477
Gastrointestinal disorder	29.29	23.01	29	44281	131210	63313502
Cardiac failure congestive	29.15	23.01	14	44296	92419	63352293
Oedema	28.98	23.01	16	44294	97606	63347106
Multiple organ dysfunction syndrome	28.88	23.01	3	44307	56749	63387963
Hypersensitivity	28.84	23.01	106	44204	292579	63152133
Sinusitis	28.82	23.01	73	44237	226580	63218132
Gastrooesophageal reflux disease	28.32	23.01	137	44173	95502	63349210
Discomfort	28.00	23.01	46	44264	167328	63277384
Mobility decreased	27.93	23.01	26	44284	121133	63323579
Neuropathy peripheral	27.89	23.01	23	44287	113644	63331068
Osteoarthritis	27.77	23.01	16	44294	95327	63349385
Therapeutic response unexpected	27.47	23.01	48	44262	18711	63426001
Reversible cerebral vasoconstriction syndrome	27.06	23.01	19	44291	2639	63442073
Osteoporosis	26.82	23.01	4	44306	57334	63387378
Drug ineffective	26.63	23.01	933	43377	1043832	62400880
Injury	26.51	23.01	9	44301	73238	63371474
Bradycardia	26.50	23.01	9	44301	73218	63371494
Dyspnoea exertional	26.45	23.01	5	44305	60297	63384415
Injection site warmth	26.42	23.01	42	44268	15153	63429559
Cough	26.30	23.01	110	44200	292633	63152079
Pain in extremity	25.96	23.01	131	44179	331355	63113357
Influenza like illness	25.28	23.01	103	44207	66721	63377991
Product use issue	25.06	23.01	75	44235	220445	63224267
Mastoiditis	25.06	23.01	13	44297	1042	63443670
Folliculitis	24.83	23.01	9	44301	70308	63374404
Lack of injection site rotation	24.79	23.01	10	44300	446	63444266
Blood cholesterol increased	24.37	23.01	18	44292	94014	63350698
Hypoglycaemia	24.27	23.01	6	44304	60059	63384653
Injection site hypoaesthesia	23.96	23.01	10	44300	487	63444225
Anuria	23.65	23.01	36	44274	12515	63432197
Multiple sclerosis relapse	23.58	23.01	3	44307	48475	63396237
Extrapyramidal disorder	23.49	23.01	37	44273	13247	63431465
Tachycardia	23.19	23.01	29	44281	118127	63326585
Deep vein thrombosis	23.10	23.01	15	44295	83785	63360927
Hip arthroplasty	23.05	23.01	3	44307	47643	63397069

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Accidental exposure to product	3067.39	49.06	631	4608	12171	34939521
Wrong technique in product usage process	1887.28	49.06	520	4719	35466	34916226
Device difficult to use	1142.72	49.06	218	5021	2679	34949013
Device issue	447.16	49.06	128	5111	9649	34942043
Drug dose omission by device	431.24	49.06	93	5146	2146	34949546
Occupational exposure to product	386.86	49.06	64	5175	311	34951381
Incorrect dose administered by device	334.32	49.06	73	5166	1785	34949907
Product storage error	312.28	49.06	93	5146	8029	34943663
Injection site haemorrhage	258.29	49.06	84	5155	9684	34942008
Migraine	238.80	49.06	92	5147	17386	34934306
Therapeutic product effect incomplete	209.25	49.06	116	5123	50425	34901267
Device use error	202.81	49.06	51	5188	2324	34949368
Constipation	193.02	49.06	161	5078	136821	34814871
Injection site pain	179.30	49.06	96	5143	38909	34912783
Injury associated with device	157.45	49.06	36	5203	1087	34950605
Underdose	151.33	49.06	62	5177	13718	34937974
Therapeutic response shortened	134.14	49.06	48	5191	7356	34944336
Incorrect disposal of product	116.82	49.06	23	5216	330	34951362
Incorrect dose administered	95.50	49.06	65	5174	40450	34911242
Headache	94.34	49.06	132	5107	200503	34751189
Therapeutic product effect decreased	87.28	49.06	58	5181	34685	34917007
Device malfunction	81.79	49.06	37	5202	10384	34941308
Injection site indentation	67.09	49.06	10	5229	20	34951672
Therapy non-responder	52.69	49.06	45	5194	39101	34912591
Wrong technique in device usage process	52.37	49.06	16	5223	1496	34950196

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Accidental exposure to product	16392.16	27.89	3675	38119	27647	79674947
Wrong technique in product usage process	15125.66	27.89	4072	37722	69803	79632791
Device difficult to use	8838.70	27.89	1908	39886	11477	79691117
Drug dose omission by device	3686.77	27.89	814	40980	5436	79697158
Device issue	2915.93	27.89	914	40880	26194	79676400
Injection site pain	1955.46	27.89	1069	40725	128769	79573825
Incorrect dose administered by device	1845.89	27.89	445	41349	4544	79698050
Device use error	1618.24	27.89	430	41364	6671	79695923
Injection site haemorrhage	1566.36	27.89	578	41216	27292	79675302
Product storage error	1499.56	27.89	488	41306	15738	79686856
Underdose	949.93	27.89	424	41370	32727	79669867
Migraine	895.44	27.89	562	41232	86931	79615663
Constipation	870.46	27.89	896	40898	282154	79420440
Device malfunction	845.42	27.89	344	41450	21104	79681490
Injury associated with device	792.23	27.89	211	41583	3295	79699299
Incorrect dose administered	770.80	27.89	487	41307	76143	79626451
Therapeutic product effect incomplete	693.81	27.89	582	41212	141063	79561531
Incorrect disposal of product	690.22	27.89	148	41646	837	79701757
Wrong technique in device usage process	534.89	27.89	160	41634	3868	79698726
Therapeutic response shortened	522.67	27.89	224	41570	15639	79686955
Injection site bruising	468.86	27.89	283	41511	40719	79661875
Device defective	320.02	27.89	91	41703	1829	79700765
Injection site indentation	310.83	27.89	58	41736	134	79702460
Needle issue	307.77	27.89	146	41648	12922	79689672
Occupational exposure to product	287.54	27.89	68	41726	632	79701962
Product communication issue	254.14	27.89	67	41727	1002	79701592
Injection site swelling	243.36	27.89	200	41594	46932	79655662
Acute kidney injury	226.74	27.89	11	41783	519393	79183201
Headache	219.24	27.89	795	40999	652977	79049617
Injection site erythema	209.88	27.89	231	41563	77966	79624628
Toxicity to various agents	190.32	27.89	7	41787	421533	79281061
Pneumonia	180.14	27.89	61	41733	660185	79042409
Product dose omission issue	177.62	27.89	397	41397	247140	79455454
Anaemia	169.68	27.89	18	41776	444997	79257597
Intercepted product administration error	166.85	27.89	40	41754	396	79702198
Blepharospasm	145.85	27.89	68	41726	5783	79696811
Pyrexia	140.13	27.89	92	41702	678617	79023977
Incorrect dose administered by product	136.97	27.89	30	41764	190	79702404
Condition aggravated	135.33	27.89	47	41747	501077	79201517
Neutropenia	132.53	27.89	4	41790	287706	79414888
Injection site urticaria	117.54	27.89	77	41717	12749	79689845
Neovascularisation	109.04	27.89	36	41758	1209	79701385
Product administered at inappropriate site	107.96	27.89	49	41745	3916	79698678
Therapeutic product effect decreased	104.40	27.89	251	41543	163612	79538982
Injection site extravasation	103.42	27.89	64	41730	9605	79692989
Inappropriate schedule of product administration	103.28	27.89	221	41573	133407	79569187
General physical health deterioration	102.62	27.89	12	41782	275226	79427368
Haemoglobin decreased	102.59	27.89	3	41791	222116	79480478
Therapy non-responder	102.47	27.89	178	41616	92127	79610467
Diarrhoea	101.97	27.89	192	41602	880297	78822297
Completed suicide	101.60	27.89	7	41787	245760	79456834
Drug interaction	97.39	27.89	48	41746	415135	79287459
Death	91.88	27.89	97	41697	566417	79136177
Drug ineffective	90.69	27.89	913	40881	1080000	78622594
Sepsis	90.55	27.89	16	41778	269412	79433182
Platelet count decreased	88.56	27.89	3	41791	194661	79507933
Muscle spasms	86.98	27.89	244	41550	174486	79528108
Oedema peripheral	86.96	27.89	14	41780	252274	79450320
Taste disorder	85.53	27.89	69	41725	15754	79686840
Device failure	84.09	27.89	48	41746	6213	79696381
Hypotension	83.74	27.89	65	41729	440252	79262342
Renal failure	79.47	27.89	7	41787	200961	79501633
Hyponatraemia	76.71	27.89	4	41790	177844	79524750
Infusion related reaction	76.65	27.89	14	41780	230223	79472371
White blood cell count decreased	75.98	27.89	6	41788	188282	79514312
Infection	73.70	27.89	18	41776	241694	79460900
Dyspnoea	72.06	27.89	221	41573	856804	78845790
Feeling abnormal	71.21	27.89	214	41580	158985	79543609
Alanine aminotransferase increased	69.05	27.89	4	41790	162566	79540028
Atrial fibrillation	68.13	27.89	11	41783	197875	79504719
Drug ineffective for unapproved indication	66.47	27.89	106	41688	51132	79651462
Cardiac failure	65.18	27.89	4	41790	154838	79547756
Dehydration	63.98	27.89	25	41769	248162	79454432
Incorrect route of product administration	63.87	27.89	85	41709	34844	79667750
Injection site mass	63.63	27.89	65	41729	20119	79682475
Drug abuse	63.42	27.89	6	41788	162685	79539909
Product packaging issue	63.41	27.89	24	41770	1209	79701385
Urinary tract infection	62.43	27.89	33	41761	274479	79428115
Blood creatinine increased	62.39	27.89	5	41789	155052	79547542
Overdose	61.74	27.89	11	41783	184195	79518399
Liquid product physical issue	60.91	27.89	23	41771	1151	79701443
Respiratory failure	60.21	27.89	11	41783	180900	79521694
Aspartate aminotransferase increased	60.16	27.89	3	41791	138638	79563956
Migraine with aura	59.96	27.89	29	41765	2676	79699918
Hypokalaemia	59.80	27.89	4	41790	144036	79558558
Injection site pruritus	59.76	27.89	91	41703	42192	79660402
Injection site rash	58.75	27.89	59	41735	17895	79684699
Fall	58.34	27.89	104	41690	487525	79215069
Product supply issue	57.95	27.89	26	41768	2022	79700572
Cardiac arrest	54.06	27.89	12	41782	172084	79530510
Epilepsy	53.64	27.89	85	41709	40775	79661819
Joint swelling	53.08	27.89	44	41750	288602	79413992
Asthenia	52.75	27.89	119	41675	511570	79191024
Injection site discomfort	52.23	27.89	33	41761	5133	79697461
Paradoxical drug reaction	51.32	27.89	37	41757	7148	79695446
Multiple organ dysfunction syndrome	50.93	27.89	3	41791	120243	79582351
Memory impairment	50.69	27.89	151	41643	111583	79591011
Synovitis	50.51	27.89	9	41785	150725	79551869
Concussion	50.43	27.89	41	41753	9462	79693132
Product dispensing error	49.80	27.89	47	41747	13216	79689378
Injection site discolouration	49.40	27.89	37	41757	7577	79695017
Gastrointestinal haemorrhage	49.11	27.89	9	41785	147710	79554884
Fear of injection	47.78	27.89	36	41758	7438	79695156
Confusional state	47.58	27.89	58	41736	317939	79384655
Arthropathy	47.04	27.89	17	41777	177094	79525500
Septic shock	46.63	27.89	5	41789	122796	79579798
Product preparation error	46.41	27.89	32	41762	5761	79696833
Leukopenia	46.20	27.89	4	41790	116509	79586085
Rheumatoid arthritis	46.02	27.89	26	41768	208444	79494150
Rubber sensitivity	45.68	27.89	21	41773	1728	79700866
Therapeutic product effect delayed	45.38	27.89	25	41769	3021	79699573
Post-traumatic neck syndrome	45.06	27.89	22	41772	2072	79700522
Stomatitis	44.57	27.89	11	41783	146746	79555848
Device delivery system issue	44.10	27.89	16	41778	715	79701879
Injection site injury	43.55	27.89	16	41778	741	79701853
Intentional product use issue	43.20	27.89	13	41781	152099	79550495
Decreased appetite	40.93	27.89	73	41721	342345	79360249
Hypoaesthesia	40.69	27.89	194	41600	179158	79523436
Oxygen saturation decreased	40.52	27.89	9	41785	129038	79573556
Swelling	39.87	27.89	33	41761	216678	79485916
Blood pressure measurement	39.28	27.89	13	41781	440	79702154
Soft tissue injury	39.19	27.89	19	41775	1762	79700832
Drug hypersensitivity	37.30	27.89	62	41732	298854	79403740
Cardiac failure congestive	37.25	27.89	14	41780	142388	79560206
Libido increased	37.09	27.89	19	41775	1982	79700612
Alopecia	36.73	27.89	227	41567	231128	79471466
Hypoglycaemia	36.45	27.89	5	41789	101589	79601005
Hepatic enzyme increased	35.88	27.89	26	41768	182584	79520010
Head discomfort	35.71	27.89	41	41753	14461	79688133
Cellulitis	35.49	27.89	7	41787	109053	79593541
Hostility	34.53	27.89	19	41775	2291	79700303
Exposure during pregnancy	33.96	27.89	6	41788	101126	79601468
Rash	33.87	27.89	172	41622	578186	79124408
Coma	33.73	27.89	6	41788	100643	79601951
Neuropathy peripheral	33.58	27.89	16	41778	141289	79561305
Paraesthesia	33.18	27.89	181	41613	176142	79526452
Sternal fracture	32.91	27.89	19	41775	2511	79700083
Tachycardia	32.78	27.89	27	41767	177741	79524853
Hemiplegic migraine	32.12	27.89	8	41786	94	79702500
C-reactive protein increased	31.61	27.89	14	41780	129013	79573581
Heart rate	31.24	27.89	8	41786	106	79702488
Vertigo	30.98	27.89	93	41701	68989	79633605
Oedema	30.87	27.89	12	41782	119568	79583026
International normalised ratio increased	30.79	27.89	4	41790	84717	79617877
Injection site reaction	30.72	27.89	80	41714	54705	79647889
Medication overuse headache	30.42	27.89	13	41781	899	79701695
Lower respiratory tract infection	30.15	27.89	15	41779	129205	79573389
Deep vein thrombosis	29.81	27.89	13	41781	120906	79581688
Influenza like illness	29.80	27.89	94	41700	71613	79630981
Therapeutic response unexpected	29.71	27.89	44	41750	19902	79682692
Wound	29.43	27.89	12	41782	116167	79586427
Hand deformity	29.29	27.89	9	41785	103910	79598684
Agitation	29.27	27.89	8	41786	99707	79602887
Pemphigus	29.21	27.89	8	41786	99574	79603020
Vascular malformation	28.91	27.89	10	41784	388	79702206
Mucosal inflammation	28.89	27.89	3	41791	75577	79627017
Bradycardia	28.37	27.89	18	41776	135539	79567055

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	N02CD01	NERVOUS SYSTEM ANALGESICS ANTIMIGRAINE PREPARATIONS Calcitonin gene-related peptide (CGRP) antagonists
MeSH PA	D000700	Analgesics
MeSH PA	D000077221	Calcitonin Gene-Related Peptide Receptor Antagonists
MeSH PA	D002491	Central Nervous System Agents
MeSH PA	D018373	Peripheral Nervous System Agents
MeSH PA	D018689	Sensory System Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Migraine	indication	37796009	DOID:6364
Prevention of migraine attacks	indication	408381007

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Calcitonin-gene-related peptide receptor	GPCR	O60894 Q16602	RAMP1_HUMAN CALRL_HUMAN	ANTIBODY BINDING	Ki	10.70		SCIENTIFIC LITERATURE	DRUG LABEL

External reference:

ID	Source
I5I8VB78VT	UNII
C4542165	UMLSCUI
CHEMBL3833329	ChEMBL_ID
DB14039	DRUGBANK_ID
D10928	KEGG_DRUG
10296	INN_ID
9250	IUPHAR_LIGAND_ID
279240	MMSL
34247	MMSL
34248	MMSL
d08796	MMSL
017547	NDDF
771590007	SNOMEDCT_US
771675000	SNOMEDCT_US
4037572	VANDF
2045613	RXNORM
C000605816	MESH_SUPPLEMENTAL_RECORD_UI

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
AIMOVIG	HUMAN PRESCRIPTION DRUG LABEL	1	55513-840	INJECTION	70 mg	SUBCUTANEOUS	BLA	30 sections
AIMOVIG	HUMAN PRESCRIPTION DRUG LABEL	1	55513-840	INJECTION	70 mg	SUBCUTANEOUS	BLA	30 sections
AIMOVIG	HUMAN PRESCRIPTION DRUG LABEL	1	55513-840	INJECTION	70 mg	SUBCUTANEOUS	BLA	30 sections
AIMOVIG	HUMAN PRESCRIPTION DRUG LABEL	1	55513-840	INJECTION	70 mg	SUBCUTANEOUS	BLA	30 sections
AIMOVIG	HUMAN PRESCRIPTION DRUG LABEL	1	55513-841	INJECTION	70 mg	SUBCUTANEOUS	BLA	30 sections
AIMOVIG	HUMAN PRESCRIPTION DRUG LABEL	1	55513-841	INJECTION	70 mg	SUBCUTANEOUS	BLA	30 sections
AIMOVIG	HUMAN PRESCRIPTION DRUG LABEL	1	55513-841	INJECTION	70 mg	SUBCUTANEOUS	BLA	30 sections
AIMOVIG	HUMAN PRESCRIPTION DRUG LABEL	1	55513-841	INJECTION	70 mg	SUBCUTANEOUS	BLA	30 sections
AIMOVIG	HUMAN PRESCRIPTION DRUG LABEL	1	55513-842	INJECTION, SOLUTION	140 mg	SUBCUTANEOUS	BLA	30 sections
AIMOVIG	HUMAN PRESCRIPTION DRUG LABEL	1	55513-842	INJECTION, SOLUTION	140 mg	SUBCUTANEOUS	BLA	30 sections
AIMOVIG	HUMAN PRESCRIPTION DRUG LABEL	1	55513-842	INJECTION, SOLUTION	140 mg	SUBCUTANEOUS	BLA	30 sections
AIMOVIG	HUMAN PRESCRIPTION DRUG LABEL	1	55513-842	INJECTION, SOLUTION	140 mg	SUBCUTANEOUS	BLA	30 sections
AIMOVIG	HUMAN PRESCRIPTION DRUG LABEL	1	55513-843	INJECTION, SOLUTION	140 mg	SUBCUTANEOUS	BLA	30 sections
AIMOVIG	HUMAN PRESCRIPTION DRUG LABEL	1	55513-843	INJECTION, SOLUTION	140 mg	SUBCUTANEOUS	BLA	30 sections
AIMOVIG	HUMAN PRESCRIPTION DRUG LABEL	1	55513-843	INJECTION, SOLUTION	140 mg	SUBCUTANEOUS	BLA	30 sections
AIMOVIG	HUMAN PRESCRIPTION DRUG LABEL	1	55513-843	INJECTION, SOLUTION	140 mg	SUBCUTANEOUS	BLA	30 sections