erenumab 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
human origin 5284 1582205-90-0

Description:

MoleculeDescription

Molfile

Synonyms:

  • erenumab
  • erenumab-aooe
  • aimovig
  • AMG 334
  • AMG-334
  • erenumab (genetical recombination)
Erenumab-aooe is a human monoclonal antibody that binds to the calcitonin gene-related peptide (CGRP) receptor and antagonizes CGRP receptor function.
  • Molecular weight:
  • Formula:
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA:
  • ALOGS:
  • ROTB: None

Drug dosage:

DoseUnitRoute
2.50 mg P

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

None

Approvals:

DateAgencyCompanyOrphan
June 23, 2021 PMDA AMGEN K.K.
May 17, 2018 FDA AMGEN INC
July 26, 2018 EMA NOVARTIS EUROPHARM LIMITED

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Accidental exposure to product 12179.88 27.36 3887 133481 38479 90452600
Wrong technique in product usage process 11197.47 27.36 4165 133203 67406 90423673
Device difficult to use 9840.04 27.36 2702 134666 14823 90476256
Drug dose omission by device 5308.18 27.36 1484 135884 8747 90482332
Device issue 1640.53 27.36 830 136538 28707 90462372
Incorrect dose administered by device 1327.40 27.36 448 136920 5289 90485790
Product storage error 1242.72 27.36 609 136759 19632 90471447
Device use error 1156.40 27.36 429 136939 6792 90484287
Injection site haemorrhage 932.59 27.36 564 136804 27754 90463325
Blepharospasm 929.32 27.36 728 136640 54717 90436362
Injection site pain 877.59 27.36 1194 136174 172505 90318574
Occupational exposure to product 869.90 27.36 267 137101 2264 90488815
Taste disorder 757.35 27.36 676 136692 60870 90430209
Nail disorder 745.18 27.36 658 136710 58409 90432670
Epilepsy 740.30 27.36 760 136608 81446 90409633
Back injury 639.82 27.36 545 136823 46077 90445002
Onychomadesis 607.42 27.36 526 136842 45472 90445607
Breast cancer stage III 599.89 27.36 689 136679 83758 90407321
Incorrect disposal of product 581.27 27.36 158 137210 820 90490259
Injury associated with device 570.38 27.36 225 137143 4239 90486840
Underdose 566.96 27.36 543 136825 53474 90437605
Gastrooesophageal reflux disease 535.09 27.36 928 136440 165409 90325670
Product label confusion 499.21 27.36 352 137016 22498 90468581
Constipation 491.70 27.36 1218 136150 279177 90211902
Device malfunction 476.59 27.36 331 137037 20646 90470433
Bursitis 466.43 27.36 767 136601 130887 90360192
Anaemia 456.68 27.36 18 137350 352784 90138295
Therapeutic product effect incomplete 456.52 27.36 947 136421 192949 90298130
Wound infection 450.70 27.36 673 136695 105729 90385350
Finger deformity 444.04 27.36 381 136987 32516 90458563
Facet joint syndrome 443.72 27.36 641 136727 97748 90393331
Intercepted product administration error 436.90 27.36 124 137244 774 90490305
Acute kidney injury 430.03 27.36 12 137356 320375 90170704
Product quality issue 416.34 27.36 556 136812 78769 90412310
Adverse reaction 415.10 27.36 351 137017 29361 90461718
Product communication issue 410.42 27.36 133 137235 1368 90489711
Peripheral venous disease 408.34 27.36 567 136801 83354 90407725
Onychomycosis 394.56 27.36 377 136991 36999 90454080
Hypercholesterolaemia 387.63 27.36 610 136758 100282 90390797
Lip dry 362.66 27.36 592 136776 100363 90390716
Neck pain 362.59 27.36 633 136735 113330 90377749
Liver function test increased 361.12 27.36 538 136830 84317 90406762
Wrong technique in device usage process 353.34 27.36 174 137194 5661 90485418
Pyrexia 338.97 27.36 302 137066 660183 89830896
Live birth 334.39 27.36 500 136868 78607 90412472
Coeliac disease 333.65 27.36 374 136994 44236 90446843
Toxicity to various agents 326.58 27.36 30 137338 287816 90203263
Therapeutic response shortened 325.18 27.36 273 137095 22606 90468473
Obesity 321.37 27.36 575 136793 104932 90386147
Neutropenia 319.53 27.36 4 137364 224900 90266179
Folliculitis 290.97 27.36 822 136546 203531 90287548
Urinary tract infection 289.54 27.36 56 137312 305576 90185503
Grip strength decreased 281.24 27.36 504 136864 92072 90399007
Memory impairment 280.42 27.36 793 136575 196451 90294628
Gait inability 279.65 27.36 658 136710 145798 90345281
Joint range of motion decreased 279.49 27.36 628 136740 135015 90356064
Incorrect dose administered 275.54 27.36 457 136911 78473 90412606
Hypoaesthesia 273.67 27.36 1070 136298 313140 90177939
Night sweats 269.60 27.36 600 136768 128166 90362913
Muscle spasms 269.35 27.36 917 136451 250966 90240113
Thrombocytopenia 268.76 27.36 11 137357 208714 90282365
Migraine 257.60 27.36 752 136616 189640 90301439
Back pain 233.88 27.36 94 137274 317081 90173998
Injection site reaction 230.97 27.36 462 136906 91618 90399461
Inflammation 225.09 27.36 688 136680 177904 90313175
Hypotension 223.25 27.36 107 137261 325290 90165789
Paraesthesia 222.34 27.36 858 136510 249468 90241611
Drug interaction 220.66 27.36 72 137296 276381 90214698
Injection site bruising 220.11 27.36 330 137038 51977 90439102
Cough 217.79 27.36 146 137222 368816 90122263
Type 2 diabetes mellitus 215.49 27.36 738 136630 202506 90288573
Injection site indentation 214.67 27.36 57 137311 266 90490813
Psoriatic arthropathy 207.99 27.36 789 136579 227546 90263533
C-reactive protein increased 207.69 27.36 676 136692 180713 90310366
Dry mouth 206.31 27.36 681 136687 183378 90307701
Lung disorder 205.55 27.36 595 136773 149288 90341791
Dyspepsia 201.78 27.36 710 136658 197450 90293629
Hepatitis 198.25 27.36 372 136996 70367 90420712
Sepsis 197.95 27.36 21 137347 179793 90311286
Completed suicide 196.12 27.36 5 137363 145053 90346026
White blood cell count decreased 190.57 27.36 17 137351 167092 90323987
Dehydration 189.72 27.36 33 137335 194414 90296665
Osteoarthritis 189.64 27.36 690 136678 195040 90296039
Fibromyalgia 188.86 27.36 714 136654 205555 90285524
Irritable bowel syndrome 184.11 27.36 711 136657 206737 90284342
Infusion site reaction 183.96 27.36 183 137185 18856 90472223
Hyponatraemia 182.86 27.36 4 137364 133534 90357545
Death 174.27 27.36 264 137104 456287 90034792
Muscle injury 171.32 27.36 623 136745 176031 90315048
Renal failure 165.01 27.36 8 137360 130999 90360080
Device defective 164.83 27.36 88 137280 3398 90487681
Intentional product use issue 164.42 27.36 708 136660 216184 90274895
Abdominal distension 157.87 27.36 496 136872 130105 90360974
Blood cholesterol increased 157.65 27.36 679 136689 207333 90283746
Needle issue 157.45 27.36 146 137222 13788 90477291
Dyspnoea 154.51 27.36 749 136619 880206 89610873
Alanine aminotransferase increased 153.09 27.36 6 137362 118332 90372747
Pruritus 151.99 27.36 376 136992 541149 89949930
Infection 151.47 27.36 196 137172 361898 90129181
Atrial fibrillation 151.24 27.36 14 137354 133597 90357482
Diarrhoea 149.26 27.36 826 136542 938364 89552715
Pleural effusion 147.22 27.36 5 137363 111986 90379093
Cardiac failure 143.55 27.36 5 137363 109491 90381588
Renal impairment 141.13 27.36 4 137364 105417 90385662
Pericarditis 138.50 27.36 789 136579 269362 90221717
Drug-induced liver injury 137.98 27.36 373 136995 89945 90401134
Erythema 137.50 27.36 89 137279 229157 90261922
Aspartate aminotransferase increased 137.45 27.36 4 137364 102933 90388146
Liver injury 137.17 27.36 567 136801 170000 90321079
Respiratory failure 135.13 27.36 12 137356 118406 90372673
Musculoskeletal pain 132.04 27.36 562 136806 170689 90320390
Helicobacter infection 130.70 27.36 684 136684 226166 90264913
Incorrect route of product administration 130.49 27.36 257 137111 50369 90440710
Fatigue 129.53 27.36 1124 136244 1152899 89338180
Sinusitis 128.33 27.36 201 137167 342887 90148192
Intentional overdose 127.72 27.36 3 137365 93831 90397248
Duodenal ulcer perforation 127.33 27.36 667 136701 220621 90270458
Hypokalaemia 126.25 27.36 23 137345 131093 90359986
Neuropathy peripheral 125.65 27.36 27 137341 136943 90354136
Oxygen saturation decreased 125.09 27.36 10 137358 107473 90383606
Rheumatic fever 124.68 27.36 511 136857 152610 90338469
Wheezing 122.44 27.36 696 136672 237384 90253695
Blood creatinine increased 122.11 27.36 8 137360 101378 90389701
Hypocholesterolaemia 121.82 27.36 91 137277 6358 90484721
Injury 117.79 27.36 601 136767 196748 90294331
Anti-cyclic citrullinated peptide antibody positive 117.54 27.36 685 136683 235748 90255331
Product use in unapproved indication 114.68 27.36 887 136481 335349 90155730
Cardiac arrest 113.58 27.36 13 137355 104922 90386157
Weight decreased 113.50 27.36 255 137113 379655 90111424
Depression 112.13 27.36 810 136558 299791 90191288
Injection site swelling 112.09 27.36 267 137101 59572 90431507
Normal newborn 107.83 27.36 154 137214 23208 90467871
Drug abuse 107.11 27.36 4 137364 82343 90408736
Cellulitis 104.90 27.36 9 137359 91328 90399751
Septic shock 103.28 27.36 6 137362 84154 90406925
Arthritis 103 27.36 63 137305 167252 90323827
Neovascularisation 102.86 27.36 50 137318 1580 90489499
Oedema peripheral 102.34 27.36 145 137223 257770 90233309
Pulmonary embolism 100.96 27.36 36 137332 130784 90360295
Gastrointestinal haemorrhage 100.69 27.36 10 137358 90238 90400841
Dysphagia 97.31 27.36 25 137343 112253 90378826
Muscular weakness 96.44 27.36 589 136779 206077 90285002
Incorrect dose administered by product 95.08 27.36 29 137339 240 90490839
Therapeutic product effect decreased 93.91 27.36 731 136637 276840 90214239
Abdominal pain upper 93.34 27.36 840 136528 331834 90159245
Hypoxia 92.53 27.36 4 137364 72395 90418684
Impaired healing 92.50 27.36 640 136728 233559 90257520
Blood glucose increased 91.06 27.36 17 137351 95229 90395850
Blister 90.98 27.36 680 136688 254318 90236761
Mobility decreased 90.24 27.36 670 136698 250064 90241015
Multiple organ dysfunction syndrome 89.99 27.36 3 137365 68333 90422746
Coma 89.67 27.36 5 137363 72627 90418452
Tachycardia 89.47 27.36 65 137303 157608 90333471
Pemphigus 88.99 27.36 820 136548 326044 90165035
Maternal exposure during pregnancy 86.58 27.36 880 136488 359183 90131896
Chills 86.52 27.36 46 137322 131935 90359144
Deep vein thrombosis 86.22 27.36 17 137351 91603 90399476
Bradycardia 84.50 27.36 13 137355 83834 90407245
Leukopenia 84.31 27.36 24 137344 100686 90390393
Dyspnoea exertional 83.35 27.36 7 137361 72281 90418798
Suicide attempt 82.45 27.36 9 137359 75390 90415689
Product administered at inappropriate site 81.61 27.36 60 137308 4091 90486988
Influenza 80.87 27.36 56 137312 139208 90351871
Hepatic enzyme 80.57 27.36 66 137302 5278 90485801
Epistaxis 79.67 27.36 16 137352 85109 90405970
Glossodynia 79.06 27.36 790 136578 320989 90170090
Hand deformity 78.90 27.36 740 136628 295622 90195457
Sleep disorder 78.08 27.36 541 136827 197489 90293590
Somnolence 77.64 27.36 123 137245 208961 90282118
Cataract 75.40 27.36 10 137358 72082 90418997
Productive cough 75.30 27.36 13 137355 77050 90414029
Overlap syndrome 74.99 27.36 78 137290 8470 90482609
Mucosal inflammation 74.26 27.36 3 137365 57622 90433457
COVID-19 74.08 27.36 88 137280 168755 90322324
Hypoglycaemia 72.31 27.36 10 137358 69838 90421241
Synovitis 72.24 27.36 791 136577 328961 90162118
Dry skin 71.87 27.36 22 137346 88051 90403028
Urticaria 71.68 27.36 757 136611 311977 90179102
Wound 71.61 27.36 738 136630 302242 90188837
C-reactive protein abnormal 71.11 27.36 381 136987 127048 90364031
Cystitis 70.39 27.36 9 137359 66709 90424370
Upper respiratory tract infection 70.10 27.36 55 137313 128263 90362816
Cardiac failure congestive 69.85 27.36 31 137337 98663 90392416
Agitation 68.54 27.36 10 137358 67088 90423991
Bronchitis 67.84 27.36 79 137289 152848 90338231
Rhinorrhoea 66.96 27.36 25 137343 88291 90402788
Injection site urticaria 66.48 27.36 107 137261 17904 90473175
Lower respiratory tract infection 66.25 27.36 625 136743 250034 90241045
Skin ulcer 63.23 27.36 3 137365 50072 90441007
Haematochezia 62.98 27.36 15 137353 70898 90420181
Chronic obstructive pulmonary disease 62.90 27.36 17 137351 73812 90417267
Circumstance or information capable of leading to medication error 61.91 27.36 55 137313 4912 90486167
Chronic kidney disease 60.31 27.36 4 137364 50187 90440892
Colitis 59.79 27.36 16 137352 69926 90421153
Gait disturbance 59.63 27.36 199 137169 260297 90230782
Sleep disorder due to general medical condition, insomnia type 58.70 27.36 65 137303 128629 90362450
Blood alkaline phosphatase increased 57.28 27.36 4 137364 48075 90443004
Diabetes mellitus 57.07 27.36 14 137354 64861 90426218
Blood pressure systolic increased 56.66 27.36 10 137358 58335 90432744
Blood pressure increased 55.92 27.36 136 137232 197081 90293998
Liver function test abnormal 55.77 27.36 6 137362 50839 90440240
Nausea 55.75 27.36 1271 136097 1109045 89382034
Pain 55.37 27.36 1122 136246 995219 89495860
Multiple sclerosis relapse 55.31 27.36 7 137361 52298 90438781
Thrombosis 55.09 27.36 21 137347 73230 90417849
Alopecia 54.83 27.36 1054 136314 494017 89997062
Hallucination 54.68 27.36 16 137352 65943 90425136
Femur fracture 54.42 27.36 4 137364 46078 90445001
Chest discomfort 53.66 27.36 79 137289 138286 90352793
Skin exfoliation 53.58 27.36 18 137350 67895 90423184
Drug intolerance 53.39 27.36 964 136404 446627 90044452
Bone pain 53.32 27.36 14 137354 61969 90429110
Syncope 53.17 27.36 74 137294 132589 90358490
Foetal exposure during pregnancy 52.92 27.36 3 137365 42972 90448107
Drug reaction with eosinophilia and systemic symptoms 52.61 27.36 3 137365 42755 90448324
Herpes zoster 52.41 27.36 40 137328 94604 90396475
Red blood cell count decreased 52.06 27.36 5 137363 46346 90444733
Haemorrhage 51.98 27.36 20 137348 69349 90421730
Systemic lupus erythematosus 51.42 27.36 802 136566 361094 90129985
Blood pressure fluctuation 50.86 27.36 9 137359 52404 90438675
Injection site erythema 50.59 27.36 288 137080 98214 90392865
Injection site extravasation 50.03 27.36 65 137303 8954 90482125
Pulmonary hypertension 49.35 27.36 4 137364 42519 90448560
Seizure 49.23 27.36 98 137270 152531 90338548
Cholelithiasis 48.86 27.36 10 137358 52496 90438583
Mouth ulceration 48.59 27.36 3 137365 39971 90451108
Orthostatic hypotension 48.36 27.36 4 137364 41823 90449256
Paradoxical drug reaction 47.71 27.36 51 137317 5715 90485364
Osteonecrosis of jaw 47.33 27.36 3 137365 39100 90451979
Eczema 47.31 27.36 11 137357 52859 90438220
Haematoma 47.25 27.36 3 137365 39045 90452034
Plasma cell myeloma 46.94 27.36 4 137364 40824 90450255
Migraine with aura 46.77 27.36 39 137329 3197 90487882
Abdominal pain 46.54 27.36 380 136988 395341 90095738
Angioedema 46.50 27.36 20 137348 64856 90426223
Heart rate decreased 46.19 27.36 12 137356 53493 90437586
Pneumonia 45.81 27.36 686 136682 637373 89853706
Oropharyngeal pain 44.43 27.36 66 137302 115121 90375958
Balance disorder 44.30 27.36 49 137319 97031 90394048
Pericardial effusion 44.07 27.36 3 137365 36830 90454249
Premature delivery 44.02 27.36 4 137364 38758 90452321
Nasal congestion 44.00 27.36 37 137331 83377 90407702
Prescribed underdose 43.68 27.36 227 137141 74792 90416287
Heart rate increased 43.25 27.36 65 137303 112837 90378242
Libido increased 43.11 27.36 29 137339 1715 90489364
Stomatitis 42.58 27.36 618 136750 274080 90216999
Blood potassium decreased 42.57 27.36 10 137358 47717 90443362
Blood pressure decreased 42.31 27.36 31 137337 74864 90416215
Muscle spasticity 41.90 27.36 3 137365 35319 90455760
Staphylococcal infection 41.55 27.36 11 137357 48428 90442651
Haematuria 41.35 27.36 3 137365 34934 90456145
General physical health deterioration 40.97 27.36 761 136607 354354 90136725
Electrocardiogram QT prolonged 40.92 27.36 30 137338 72426 90418653
Rubber sensitivity 40.61 27.36 34 137334 2803 90488276
Soft tissue injury 40.59 27.36 30 137338 2062 90489017
Mental status changes 40.57 27.36 9 137359 44670 90446409
Chest pain 40.34 27.36 301 137067 319344 90171735
Fungal infection 39.96 27.36 8 137360 42653 90448426
Post-traumatic neck syndrome 39.91 27.36 32 137336 2482 90488597
Myalgia 39.91 27.36 134 137234 174991 90316088
Breast cancer stage II 39.75 27.36 131 137237 35203 90455876
Respiratory tract infection 39.58 27.36 20 137348 59058 90432021
Rash erythematous 39.38 27.36 25 137343 65079 90426000
Haemoptysis 39.04 27.36 3 137365 33317 90457762
Respiratory arrest 39.03 27.36 3 137365 33308 90457771
Hypothyroidism 38.69 27.36 16 137352 53111 90437968
Hyperhidrosis 38.62 27.36 94 137274 136211 90354868
Dysphonia 38.46 27.36 24 137344 63060 90428019
Drug ineffective for unapproved indication 38.35 27.36 201 137167 66443 90424636
Joint injury 38.11 27.36 3 137365 32661 90458418
Rash maculo-papular 37.67 27.36 8 137360 40925 90450154
Hypercalcaemia 37.66 27.36 4 137364 34236 90456843
Hypophagia 37.54 27.36 5 137363 35932 90455147
Lethargy 37.16 27.36 25 137343 63114 90427965
Oral candidiasis 36.88 27.36 5 137363 35450 90455629
Drug eruption 36.81 27.36 5 137363 35402 90455677
Hostility 36.23 27.36 29 137339 2244 90488835
Emotional distress 36.22 27.36 6 137362 36656 90454423
Unresponsive to stimuli 36.02 27.36 7 137361 38114 90452965
Tooth disorder 35.87 27.36 3 137365 31087 90459992
Gamma-glutamyltransferase increased 35.79 27.36 7 137361 37945 90453134
Injection site injury 35.74 27.36 21 137347 978 90490101
Clostridium difficile infection 35.66 27.36 6 137362 36239 90454840
Vascular malformation 35.60 27.36 19 137349 733 90490346
Disease recurrence 35.39 27.36 7 137361 37646 90453433
Ill-defined disorder 35.28 27.36 432 136936 184459 90306620
Respiratory distress 35.05 27.36 8 137360 38938 90452141
Loss of consciousness 34.98 27.36 103 137265 140135 90350944
Blood creatine phosphokinase increased 34.91 27.36 5 137363 34018 90457061
Asthma 34.52 27.36 220 137148 241940 90249139
Hepatic steatosis 34.45 27.36 7 137361 36938 90454141
Paranasal cyst 34.28 27.36 19 137349 791 90490288
Rheumatoid arthritis 33.84 27.36 753 136615 361861 90129218
Dysuria 33.70 27.36 9 137359 39392 90451687
Ulcer 33.35 27.36 5 137363 32877 90458202
Anaphylactic reaction 32.93 27.36 51 137317 87473 90403606
Vision blurred 32.90 27.36 74 137294 110219 90380860
Product packaging issue 32.89 27.36 24 137344 1617 90489462
Pallor 32.86 27.36 6 137362 34159 90456920
Pulmonary mass 32.59 27.36 3 137365 28769 90462310
Medication overuse headache 32.49 27.36 23 137345 1478 90489601
Haematemesis 32.27 27.36 6 137362 33720 90457359
Sinus tachycardia 32.22 27.36 3 137365 28510 90462569
Sternal fracture 32.13 27.36 30 137338 2857 90488222
Skin disorder 32.13 27.36 8 137360 36698 90454381
Localised infection 32.05 27.36 6 137362 33556 90457523
Abdominal pain lower 32 27.36 4 137364 30173 90460906
Procedural pain 31.78 27.36 6 137362 33354 90457725
Knee arthroplasty 31.75 27.36 48 137320 83134 90407945
Myocardial infarction 31.69 27.36 71 137297 105901 90385178
Urinary retention 31.57 27.36 9 137359 37735 90453344
Dry eye 31.42 27.36 25 137343 57906 90433173
Pollakiuria 31.31 27.36 6 137362 32999 90458080
Product supply issue 31.22 27.36 30 137338 2962 90488117
Device failure 31.14 27.36 45 137323 6852 90484227
Pain in jaw 31.03 27.36 17 137351 47968 90443111
Ulcer haemorrhage 30.89 27.36 99 137269 26222 90464857
Depressed level of consciousness 30.79 27.36 39 137329 72745 90418334
Candida infection 30.64 27.36 7 137361 34050 90457029
Unevaluable event 30.59 27.36 23 137345 54825 90436254
Blood pressure measurement 30.36 27.36 14 137354 392 90490687
Acute respiratory distress syndrome 29.94 27.36 4 137364 28682 90462397
Headache 29.78 27.36 1595 135773 861151 89629928
Cognitive disorder 29.56 27.36 37 137331 69370 90421709
Oral pain 28.85 27.36 7 137361 32676 90458403
Rheumatoid factor positive 28.73 27.36 148 137220 171502 90319577
Eye irritation 28.61 27.36 8 137360 33970 90457109
Psoriasis 28.50 27.36 121 137247 147633 90343446
Device related infection 28.39 27.36 3 137365 25783 90465296
Fall 28.33 27.36 537 136831 481273 90009806
Mastoiditis 28.10 27.36 22 137346 1648 90489431
Arthralgia 28.10 27.36 933 136435 777589 89713490
Oral herpes 28.03 27.36 8 137360 33516 90457563
Incorrect product administration duration 27.70 27.36 78 137290 19244 90471835
Skin lesion 27.62 27.36 11 137357 37354 90453725

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Accidental exposure to product 3073.51 44.41 681 5425 19712 42595517
Wrong technique in product usage process 2006.94 44.41 561 5545 42074 42573155
Device difficult to use 1556.97 44.41 302 5804 4294 42610935
Drug dose omission by device 692.80 44.41 162 5944 5724 42609505
Occupational exposure to product 435.91 44.41 72 6034 365 42614864
Product storage error 418.58 44.41 124 5982 11016 42604213
Device issue 407.58 44.41 127 5979 13382 42601847
Incorrect dose administered by device 345.82 44.41 80 6026 2676 42612553
Injection site haemorrhage 274.55 44.41 91 6015 11645 42603584
Migraine 235.70 44.41 100 6006 25314 42589915
Device use error 213.86 44.41 56 6050 3141 42612088
Constipation 185.24 44.41 166 5940 162125 42453104
Injury associated with device 182.89 44.41 42 6064 1355 42613874
Therapeutic product effect incomplete 179.99 44.41 117 5989 70822 42544407
Injection site pain 170.76 44.41 105 6001 57693 42557536
Intercepted product administration error 148.15 44.41 30 6076 525 42614704
Underdose 142.60 44.41 62 6044 16604 42598625
Incorrect disposal of product 119.72 44.41 24 6082 398 42614831
Therapeutic response shortened 111.31 44.41 49 6057 13505 42601724
Headache 106.76 44.41 150 5956 239219 42376010
Therapeutic product effect decreased 97.70 44.41 64 6042 39086 42576143
Incorrect dose administered 84.62 44.41 66 6040 52908 42562321
Device malfunction 83.58 44.41 39 6067 12288 42602941
Injection site indentation 73.42 44.41 12 6094 56 42615173
Post concussion syndrome 61.89 44.41 12 6094 166 42615063
Wrong technique in device usage process 51.17 44.41 18 6088 2739 42612490
Injection site bruising 47.37 44.41 26 6080 11499 42603730
Product communication issue 44.43 44.41 13 6093 1096 42614133

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Accidental exposure to product 12880.94 35.97 3995 129218 46013 110410073
Wrong technique in product usage process 12541.83 35.97 4490 128723 82858 110373228
Device difficult to use 10401.99 35.97 2730 130483 16075 110440011
Drug dose omission by device 5481.52 35.97 1562 131651 12954 110443132
Device issue 1923.57 35.97 904 132309 33631 110422455
Incorrect dose administered by device 1563.87 35.97 500 132713 6314 110449772
Device use error 1282.44 35.97 463 132750 8626 110447460
Product storage error 1152.06 35.97 550 132663 21178 110434908
Injection site haemorrhage 1101.77 35.97 612 132601 32416 110423670
Injection site pain 994.62 35.97 1147 132066 176775 110279311
Blepharospasm 984.50 35.97 685 132528 54166 110401920
Nail disorder 903.00 35.97 664 132549 57271 110398815
Taste disorder 784.96 35.97 642 132571 64745 110391341
Breast cancer stage III 731.24 35.97 669 132544 78448 110377638
Back injury 729.02 35.97 539 132674 46860 110409226
Onychomadesis 726.55 35.97 530 132683 45133 110410953
Epilepsy 705.86 35.97 730 132483 99479 110356607
Acute kidney injury 701.57 35.97 13 133200 635417 109820669
Underdose 700.59 35.97 594 132619 62960 110393126
Injury associated with device 650.79 35.97 232 132981 4157 110451929
Wound infection 638.81 35.97 680 132533 95785 110360301
Incorrect disposal of product 610.95 35.97 167 133046 1161 110454925
Bursitis 579.96 35.97 748 132465 129170 110326916
Product label confusion 578.04 35.97 353 132860 22324 110433762
Gastrooesophageal reflux disease 572.71 35.97 881 132332 179095 110276991
Anaemia 570.64 35.97 20 133193 547066 109909020
Facet joint syndrome 553.61 35.97 632 132581 96196 110359890
Hypercholesterolaemia 548.51 35.97 610 132603 90227 110365859
Finger deformity 532.97 35.97 387 132826 32705 110423381
Device malfunction 531.97 35.97 350 132863 25208 110430878
Folliculitis 528.23 35.97 817 132396 166836 110289250
Product quality issue 510.11 35.97 544 132669 76755 110379331
Peripheral venous disease 496.07 35.97 558 132655 83559 110372527
Therapeutic product effect incomplete 484.16 35.97 923 132290 222882 110233204
Adverse reaction 483.22 35.97 349 132864 29245 110426841
Onychomycosis 478.49 35.97 386 132827 38145 110417941
Lip dry 457.21 35.97 583 132630 99500 110356586
Toxicity to various agents 455.34 35.97 32 133181 480523 109975563
Live birth 454.94 35.97 487 132726 68997 110387089
Pyrexia 445.32 35.97 266 132947 897999 109558087
Neck pain 434.75 35.97 633 132580 122497 110333589
Liver function test increased 423.83 35.97 528 132685 88020 110368066
Coeliac disease 422.10 35.97 377 132836 42810 110413276
Neutropenia 420.08 35.97 6 133207 374614 110081472
Grip strength decreased 419.33 35.97 500 132713 79674 110376412
Joint range of motion decreased 416.66 35.97 617 132596 121215 110334871
Gait inability 400.95 35.97 644 132569 135732 110320354
Obesity 400.56 35.97 583 132630 112768 110343318
Product communication issue 392.58 35.97 138 133075 2368 110453718
Type 2 diabetes mellitus 388.18 35.97 735 132478 176497 110279589
Wrong technique in device usage process 388.12 35.97 182 133031 6719 110449367
Psoriatic arthropathy 386.05 35.97 779 132434 195982 110260104
Pemphigus 377.15 35.97 812 132401 213758 110242328
Hypoaesthesia 376.21 35.97 1025 132188 313198 110142888
Memory impairment 374.86 35.97 770 132443 196174 110259912
Drug interaction 370.20 35.97 76 133137 500107 109955979
Thrombocytopenia 366.21 35.97 12 133201 348873 110107213
Irritable bowel syndrome 365.80 35.97 686 132527 163529 110292557
Muscle injury 360.54 35.97 625 132588 140182 110315904
Fibromyalgia 359.79 35.97 697 132516 170212 110285874
Night sweats 344.72 35.97 596 132617 133387 110322699
Migraine 337.15 35.97 680 132533 170972 110285114
Glossodynia 332.01 35.97 788 132425 221216 110234870
Osteoarthritis 328.80 35.97 698 132515 181925 110274161
Hypotension 326.40 35.97 112 133101 523737 109932349
Pericarditis 325.79 35.97 776 132437 218338 110237748
Helicobacter infection 318.07 35.97 687 132526 181190 110274896
Sepsis 315.21 35.97 20 133193 327326 110128760
Incorrect dose administered 313.60 35.97 496 132717 103145 110352941
Anti-cyclic citrullinated peptide antibody positive 310.94 35.97 681 132532 181303 110274783
Duodenal ulcer perforation 296.84 35.97 659 132554 177041 110279045
Maternal exposure during pregnancy 295.54 35.97 822 132391 254061 110202025
Dyspepsia 295.48 35.97 687 132526 190278 110265808
Injection site indentation 289.89 35.97 68 133145 226 110455860
Death 289.63 35.97 250 132963 698619 109757467
Hand deformity 289.01 35.97 740 132473 217766 110238320
Occupational exposure to product 288.34 35.97 84 133129 755 110455331
Muscle spasms 285.81 35.97 859 132354 277298 110178788
Intercepted product administration error 285.14 35.97 84 133129 788 110455298
Inflammation 283.59 35.97 681 132532 192557 110263529
Haemoglobin decreased 278.67 35.97 4 133209 248723 110207363
Systemic lupus erythematosus 273.22 35.97 798 132415 253540 110202546
Blood cholesterol increased 267.70 35.97 648 132565 184137 110271949
Injection site reaction 264.95 35.97 423 132790 88647 110367439
Rheumatic fever 264.12 35.97 505 132708 122074 110334012
Liver injury 262.75 35.97 568 132645 149845 110306241
Completed suicide 259.16 35.97 7 133206 242374 110213712
Platelet count decreased 256.91 35.97 4 133209 230439 110225647
Dry mouth 254.97 35.97 668 132545 199280 110256806
Wound 253.16 35.97 737 132476 233700 110222386
Injection site bruising 252.16 35.97 310 132903 50953 110405133
Urinary tract infection 248.80 35.97 46 133167 326236 110129850
Therapeutic response shortened 247.84 35.97 237 132976 29346 110426740
Paraesthesia 244.62 35.97 811 132402 275710 110180376
Hyponatraemia 241.70 35.97 4 133209 217649 110238437
Renal failure 240.55 35.97 7 133206 226567 110229519
Cough 236.37 35.97 131 133082 461510 109994576
Impaired healing 231.47 35.97 638 132575 196079 110260007
Dehydration 229.73 35.97 32 133181 279479 110176607
Synovitis 226.70 35.97 786 132427 273306 110182780
Injury 225.75 35.97 592 132621 176673 110279413
Atrial fibrillation 221.11 35.97 14 133199 229628 110226458
Lung disorder 218.87 35.97 591 132622 179456 110276630
White blood cell count decreased 217.87 35.97 15 133198 229375 110226711
Constipation 217.20 35.97 930 132283 356856 110099230
Back pain 213.15 35.97 90 133123 370906 110085180
C-reactive protein increased 211.61 35.97 660 132553 217259 110238827
Respiratory failure 207.70 35.97 13 133200 215319 110240767
Cardiac failure 206.06 35.97 4 133209 187622 110268464
Hepatitis 202.63 35.97 378 132835 89676 110366410
Infusion site reaction 202.42 35.97 169 133044 17513 110438573
Intentional product use issue 200.72 35.97 706 132507 247200 110208886
Therapeutic product effect decreased 198.86 35.97 697 132516 243619 110212467
Pleural effusion 198.43 35.97 3 133210 177706 110278380
Musculoskeletal pain 194.28 35.97 572 132641 182451 110273635
Alanine aminotransferase increased 193.89 35.97 6 133207 183767 110272319
Mobility decreased 192.08 35.97 676 132537 236746 110219340
Alopecia 191.32 35.97 908 132305 363845 110092241
Cardiac arrest 189.40 35.97 12 133201 196741 110259345
Blister 188.79 35.97 653 132560 226723 110229363
Device defective 188.16 35.97 92 133121 3730 110452356
Drug abuse 186.43 35.97 6 133207 177405 110278681
Blood creatinine increased 185.95 35.97 8 133205 182881 110273205
Wheezing 184.80 35.97 701 132512 254529 110201557
Dyspnoea 178.64 35.97 708 132505 1106164 109349922
Aspartate aminotransferase increased 169.53 35.97 5 133208 159931 110296155
Needle issue 163.01 35.97 150 133063 17690 110438396
Multiple organ dysfunction syndrome 159.87 35.97 5 133208 151705 110304381
Septic shock 159.78 35.97 7 133206 157521 110298565
Depression 159.15 35.97 780 132433 316555 110139531
Pulmonary embolism 157.63 35.97 33 133180 214441 110241645
Gastrointestinal haemorrhage 156.64 35.97 11 133202 165507 110290579
Drug intolerance 155.02 35.97 927 132286 405585 110050501
Erythema 151.55 35.97 81 133132 291366 110164720
Oxygen saturation decreased 149.82 35.97 10 133203 156972 110299114
Rheumatoid arthritis 149.20 35.97 735 132478 298878 110157208
Hypokalaemia 147.29 35.97 22 133191 182426 110273660
Neuropathy peripheral 146.15 35.97 21 133192 179256 110276830
Diarrhoea 142.51 35.97 799 132414 1138706 109317380
Normal newborn 142.41 35.97 153 133060 21743 110434343
Sleep disorder 141.60 35.97 543 132670 198101 110257985
Lower respiratory tract infection 141.33 35.97 624 132589 242482 110213604
Hypocholesterolaemia 141.09 35.97 91 133122 6330 110449756
Abdominal pain upper 135.55 35.97 800 132413 348311 110107775
Contraindicated product administered 134.42 35.97 624 132589 247643 110208443
Drug-induced liver injury 130.95 35.97 379 132834 119688 110336398
Abdominal distension 129.21 35.97 484 132729 174619 110281467
Arthropathy 126.21 35.97 681 132532 286841 110169245
C-reactive protein abnormal 124.14 35.97 391 132822 129304 110326782
Incorrect dose administered by product 123.80 35.97 34 133179 241 110455845
COVID-19 121.79 35.97 72 133141 244988 110211098
Urticaria 118.85 35.97 723 132490 318134 110137952
Tachycardia 117.80 35.97 63 133150 226582 110229504
Cellulitis 117.44 35.97 9 133204 126007 110330079
Coma 117.07 35.97 6 133207 117863 110338223
Bradycardia 116.19 35.97 23 133190 155494 110300592
Weight decreased 115.83 35.97 244 132969 467813 109988273
Somnolence 115.13 35.97 113 133100 297336 110158750
Deep vein thrombosis 114.92 35.97 16 133197 139871 110316215
Chills 114.67 35.97 43 133170 190537 110265549
Hypoglycaemia 111.96 35.97 7 133206 116097 110339989
Neovascularisation 110.79 35.97 50 133163 1687 110454399
Incorrect route of product administration 110.73 35.97 241 132972 63820 110392266
Muscular weakness 110.04 35.97 590 132623 247878 110208208
Leukopenia 109.10 35.97 23 133190 148768 110307318
Oedema peripheral 108.54 35.97 142 133071 328518 110127568
Dysphagia 108.10 35.97 26 133187 153574 110302512
Blood glucose increased 106.88 35.97 16 133197 132480 110323606
Ill-defined disorder 106.25 35.97 422 132791 156431 110299655
Agitation 105.56 35.97 8 133205 113043 110343043
Pruritus 104.68 35.97 355 132858 581205 109874881
Stomatitis 102.73 35.97 616 132597 269626 110186460
Epistaxis 102.32 35.97 17 133196 130355 110325731
Suicide attempt 100.40 35.97 6 133207 103388 110352698
Infection 99.87 35.97 177 133036 362023 110094063
Hepatic enzyme increased 99.64 35.97 695 132518 320197 110135889
Hepatic enzyme 98.50 35.97 67 133146 5096 110450990
Swelling 98.48 35.97 742 132471 350299 110105787
Mucosal inflammation 98.39 35.97 4 133209 96137 110359949
Syncope 97.16 35.97 62 133151 202474 110253612
Cardiac failure congestive 94.37 35.97 32 133181 150968 110305118
Haematochezia 93.06 35.97 14 133199 115510 110340576
Seizure 92.75 35.97 78 133135 221107 110234979
Injection site swelling 91.86 35.97 219 132994 61571 110394515
Dyspnoea exertional 90.11 35.97 10 133203 104050 110352036
Exposure during pregnancy 89.97 35.97 420 132793 167004 110289082
Headache 89.96 35.97 1527 131686 880850 109575236
Productive cough 89.49 35.97 15 133198 114290 110341796
Hyperglycaemia 88.94 35.97 3 133210 85087 110370999
Overlap syndrome 88.32 35.97 79 133134 8980 110447106
International normalised ratio increased 87.51 35.97 4 133209 86768 110369318
Haematuria 86.50 35.97 3 133210 83002 110373084
Pneumonia 86.42 35.97 660 132553 876054 109580032
Chronic obstructive pulmonary disease 86.18 35.97 14 133199 109144 110346942
Drug reaction with eosinophilia and systemic symptoms 85.44 35.97 3 133210 82092 110373994
Diabetes mellitus 84.93 35.97 10 133203 99371 110356715
Pneumonia aspiration 84.43 35.97 3 133210 81230 110374856
Myocardial infarction 83.95 35.97 65 133148 192018 110264068
Colitis 83.35 35.97 12 133201 102311 110353775
Product use in unapproved indication 82.67 35.97 863 132350 446514 110009572
Product administered at inappropriate site 82.13 35.97 61 133152 5332 110450754
Encephalopathy 80.89 35.97 4 133209 81051 110375035
Thrombosis 79.24 35.97 17 133196 108645 110347441
Influenza 78.09 35.97 54 133159 169047 110287039
Hallucination 77.90 35.97 14 133199 101418 110354668
Abdominal discomfort 75.72 35.97 766 132447 393092 110062994
Chronic kidney disease 75.39 35.97 4 133209 76287 110379799
Dry skin 74.23 35.97 19 133194 107634 110348452
Haemorrhage 73.24 35.97 19 133194 106673 110349413
Haemoptysis 72.91 35.97 3 133210 71351 110384735
Coronary artery disease 70.09 35.97 4 133209 71686 110384400
Blood pressure systolic increased 69.33 35.97 9 133204 82982 110373104
Blood alkaline phosphatase increased 69.23 35.97 4 133209 70931 110385155
Blood creatine phosphokinase increased 68.71 35.97 5 133208 73072 110383014
Blood pressure increased 67.86 35.97 130 133083 258243 110197843
Product use issue 67.67 35.97 622 132591 311073 110145013
Fatigue 67.20 35.97 1046 132167 1214912 109241174
Infusion related reaction 66.98 35.97 728 132485 380434 110075652
Mental status changes 64.21 35.97 8 133205 76114 110379972
Skin ulcer 63.96 35.97 3 133210 63642 110392444
Rhinorrhoea 63.72 35.97 22 133191 102644 110353442
Red blood cell count decreased 63.48 35.97 4 133209 65919 110390167
Cataract 63.18 35.97 10 133203 79475 110376611
Gastrointestinal disorder 63.12 35.97 503 132710 241449 110214637
Angioedema 63.08 35.97 20 133193 98480 110357606
Arthritis 62.15 35.97 66 133147 167520 110288566
Weight increased 61.95 35.97 775 132438 418869 110037217
Chest discomfort 61.69 35.97 71 133142 173777 110282309
Skin exfoliation 61.34 35.97 15 133198 87636 110368450
Herpes zoster 61.04 35.97 27 133186 108352 110347734
Blood pressure fluctuation 60.42 35.97 9 133204 74815 110381271
Blood pressure decreased 59.76 35.97 32 133181 115059 110341027
Abdominal pain 59.44 35.97 368 132845 512621 109943465
Liver function test abnormal 58.76 35.97 7 133206 68943 110387143
Prescribed underdose 58.26 35.97 192 133021 64982 110391104
Lethargy 58.17 35.97 20 133193 93556 110362530
Haematoma 57.99 35.97 3 133210 58473 110397613
Injection site erythema 57.92 35.97 246 132967 93930 110362156
Sinusitis 57.55 35.97 175 133038 296513 110159573
Rash maculo-papular 57.52 35.97 10 133203 74212 110381874
Urinary retention 57.16 35.97 8 133205 69675 110386411
Pancreatitis acute 57.03 35.97 4 133209 60270 110395816
Heart rate decreased 56.30 35.97 15 133198 82741 110373345
Respiratory distress 56.27 35.97 8 133205 68866 110387220
Electrocardiogram QT prolonged 55.55 35.97 31 133182 108929 110347157
Eczema 55.46 35.97 10 133203 72283 110383803
Gamma-glutamyltransferase increased 55.41 35.97 5 133208 61304 110394782
Loss of consciousness 54.91 35.97 95 133118 196211 110259875
Hyperhidrosis 54.83 35.97 88 133125 187210 110268876
Injection site extravasation 54.08 35.97 64 133149 10105 110445981
Cerebrovascular accident 53.24 35.97 85 133128 181199 110274887
Unresponsive to stimuli 53.09 35.97 7 133206 63783 110392303
Aggression 53.05 35.97 5 133208 59205 110396881
Staphylococcal infection 52.96 35.97 10 133203 69934 110386152
Injection site urticaria 52.87 35.97 83 133130 17132 110438954
General physical health deterioration 52.28 35.97 760 132453 424535 110031551
Acute respiratory distress syndrome 51.91 35.97 3 133210 53195 110402891
Pulmonary hypertension 51.29 35.97 4 133209 55216 110400870
Peripheral swelling 51.25 35.97 726 132487 403308 110052778
Cystitis 50.95 35.97 9 133204 66027 110390059
Heart rate increased 50.75 35.97 59 133154 143775 110312311
Clostridium difficile infection 50.68 35.97 3 133210 52126 110403960
Bronchitis 50.63 35.97 69 133144 156963 110299123
Nasopharyngitis 50.57 35.97 710 132503 393651 110062435
Haematemesis 50.37 35.97 6 133207 59102 110396984
Cholelithiasis 50.36 35.97 8 133205 63414 110392672
Acute myocardial infarction 50.21 35.97 19 133194 83758 110372328
Pallor 49.98 35.97 5 133208 56462 110399624
Treatment failure 49.83 35.97 532 132681 276702 110179384
Disease recurrence 49.80 35.97 7 133206 60777 110395309
Anaphylactic reaction 49.53 35.97 39 133174 114261 110341825
Dysuria 49.20 35.97 7 133206 60224 110395862
Ventricular tachycardia 48.25 35.97 3 133210 50006 110406080
Dislocation of vertebra 47.63 35.97 138 133075 43583 110412503
Chest pain 47.29 35.97 263 132950 376112 110079974
Drug eruption 46.85 35.97 5 133208 53654 110402432
Psychotic disorder 46.45 35.97 4 133209 50933 110405153
Hypothyroidism 46.33 35.97 15 133198 72884 110383202
Cerebral haemorrhage 45.69 35.97 11 133202 64957 110391129
Multiple sclerosis relapse 45.66 35.97 4 133209 50236 110405850
Post-traumatic neck syndrome 45.56 35.97 32 133181 2563 110453523
Upper respiratory tract infection 45.13 35.97 55 133158 131273 110324813
Nasal congestion 44.55 35.97 32 133181 98250 110357836
Soft tissue injury 44.52 35.97 30 133183 2246 110453840
Vascular malformation 44.33 35.97 21 133192 793 110455293
Depressed level of consciousness 44.16 35.97 42 133171 112236 110343850
Oropharyngeal pain 44.05 35.97 59 133154 135217 110320869
Fungal infection 43.69 35.97 5 133208 50801 110405285
Rash erythematous 43.60 35.97 22 133191 81810 110374276
Rectal haemorrhage 43.53 35.97 48 133165 119785 110336301
Hypophagia 43.26 35.97 6 133207 52620 110403466
Hypertension 43.15 35.97 858 132355 509226 109946860
Device failure 42.77 35.97 48 133165 7159 110448927
Cerebral infarction 42.40 35.97 6 133207 51832 110404254
Bone pain 42.11 35.97 13 133200 65120 110390966
Gait disturbance 42.10 35.97 182 133031 278026 110178060
Breast cancer stage II 41.73 35.97 98 133115 27277 110428809
Respiratory tract infection 41.67 35.97 17 133196 71600 110384486
Concussion 41.66 35.97 60 133153 11478 110444608
Hypercalcaemia 41.64 35.97 4 133209 46653 110409433
Bacterial infection 40.95 35.97 4 133209 46032 110410054
Prescribed overdose 40.80 35.97 211 133002 87370 110368716
Mouth ulceration 40.74 35.97 5 133208 48133 110407953
Myalgia 40.43 35.97 135 133078 222246 110233840
Product packaging issue 40.00 35.97 25 133188 1646 110454440
Balance disorder 39.85 35.97 49 133164 116511 110339575
Paranasal cyst 39.30 35.97 20 133193 884 110455202
Libido increased 39.29 35.97 29 133184 2510 110453576
Migraine with aura 39.19 35.97 33 133180 3459 110452627
Dysarthria 38.64 35.97 27 133186 84094 110371992
Transaminases increased 38.62 35.97 14 133199 63376 110392710
Treatment noncompliance 38.33 35.97 20 133193 72970 110383116
Drug dependence 38.20 35.97 7 133206 50013 110406073
Ulcer haemorrhage 37.96 35.97 84 133129 22487 110433599
Coagulopathy 37.89 35.97 3 133210 40908 110415178
Skin lesion 37.80 35.97 8 133205 51623 110404463
Hostility 37.74 35.97 29 133184 2667 110453419
Femur fracture 36.72 35.97 5 133208 44464 110411622
Arrhythmia 36.63 35.97 19 133194 69556 110386530
Blood potassium decreased 36.45 35.97 10 133203 54104 110401982
Musculoskeletal stiffness 36.33 35.97 505 132708 279317 110176769
Device related infection 36.32 35.97 3 133210 39516 110416570
Disorientation 36.18 35.97 20 133193 70651 110385435

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC N02CD01 NERVOUS SYSTEM
ANALGESICS
ANTIMIGRAINE PREPARATIONS
Calcitonin gene-related peptide (CGRP) antagonists
MeSH PA D000077221 Calcitonin Gene-Related Peptide Receptor Antagonists
MeSH PA D000700 Analgesics
MeSH PA D002491 Central Nervous System Agents
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D018689 Sensory System Agents
CHEBI has role CHEBI:35554 cardiovascular drug

Related Drugs by ATC class:

N02CD Calcitonin gene-related peptide (CGRP) antagonists 7 drugs
atogepanteptinezumabfremanezumabgalcanezumabrimegepantubrogepantzavegepant

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Migraine indication 37796009 DOID:6364
Prevention of migraine attacks indication 408381007




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Calcitonin-gene-related peptide receptor GPCR ANTIBODY BINDING Ki 10.70 SCIENTIFIC LITERATURE DRUG LABEL

External reference:

IDSource
I5I8VB78VT UNII
4037572 VANDF
C4542165 UMLSCUI
CHEBI:755924 CHEBI
CHEMBL3833329 ChEMBL_ID
DB14039 DRUGBANK_ID
D10928 KEGG_DRUG
10296 INN_ID
C000605816 MESH_SUPPLEMENTAL_RECORD_UI
9250 IUPHAR_LIGAND_ID
771590007 SNOMEDCT_US
771675000 SNOMEDCT_US
279240 MMSL
34247 MMSL
34248 MMSL
d08796 MMSL
017547 NDDF
2045613 RXNORM

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
AIMOVIG HUMAN PRESCRIPTION DRUG LABEL 1 55513-840 INJECTION 70 mg SUBCUTANEOUS BLA 30 sections
AIMOVIG HUMAN PRESCRIPTION DRUG LABEL 1 55513-841 INJECTION 70 mg SUBCUTANEOUS BLA 30 sections
AIMOVIG HUMAN PRESCRIPTION DRUG LABEL 1 55513-842 INJECTION, SOLUTION 140 mg SUBCUTANEOUS BLA 30 sections
AIMOVIG HUMAN PRESCRIPTION DRUG LABEL 1 55513-843 INJECTION, SOLUTION 140 mg SUBCUTANEOUS BLA 30 sections