Stem definition | Drug id | CAS RN |
---|---|---|
antibiotics, cefalosporanic acid derivatives | 527 | 34444-01-4 |
Dose | Unit | Route |
---|---|---|
6 | g | P |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 3 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 333 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 96 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 334.50 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 96 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Vd (Volume of distribution) | 0.16 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 3.60 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.25 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 0.75 hours | Lombardo F, Berellini G, Obach RS |
None
None
None
None
None
Source | Code | Description |
---|---|---|
ATC | J01DC03 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIBACTERIALS FOR SYSTEMIC USE OTHER BETA-LACTAM ANTIBACTERIALS Second-generation cephalosporins |
CHEBI has role | CHEBI:36047 | antibacterial drugs |
MeSH PA | D000900 | Anti-Bacterial Agents |
MeSH PA | D000890 | Anti-Infective Agents |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Septicemia due to Escherichia coli | indication | 9323009 | |
Bacterial septicemia | indication | 10001005 | DOID:0040085 |
Infection of skin AND/OR subcutaneous tissue | indication | 19824006 | |
Staphylococcal pneumonia | indication | 22754005 | |
Streptococcal septicemia | indication | 29577008 | |
Pneumonia due to Streptococcus | indication | 34020007 | |
Peritonitis | indication | 48661000 | |
Lower respiratory tract infection | indication | 50417007 | |
Pneumonia due to Escherichia coli | indication | 51530003 | |
Klebsiella cystitis | indication | 60867007 | |
Urinary tract infectious disease | indication | 68566005 | |
Haemophilus influenzae pneumonia | indication | 70036007 | |
Infection due to Escherichia coli | indication | 71057007 | |
Infection of bone | indication | 111253001 | |
Staphylococcal septicemia | indication | 111821004 | |
Infectious disease of abdomen | indication | 128070006 | |
Infection due to Enterobacteriaceae | indication | 128945009 | |
Bacterial infection due to Klebsiella pneumoniae | indication | 186435004 | |
Proteus pneumonia | indication | 195888009 | |
Bacterial peritonitis | indication | 197171003 | |
Pneumonia | indication | 233604007 | DOID:552 |
Escherichia coli urinary tract infection | indication | 301011002 | |
Proteus urinary tract infection | indication | 301012009 | |
Streptococcus pyogenes infection | indication | 302809008 | |
Bacterial urinary infection | indication | 312124009 | |
Infectious disorder of joint | indication | 363162000 | |
Infection due to Staphylococcus aureus | indication | 406602003 | |
Osteomyelitis due to Staphylococcus aureus | indication | 428783003 | |
Enterococcus Urinary Tract Infection | indication | ||
Haemophilus Septicemia | indication | ||
Skin and Skin Structure Proteus Infection | indication | ||
Staphylococcus Epidermidis Urinary Tract Infection | indication | ||
Staphylococcus Aureus Joint Infection | indication | ||
E. Coli Peritonitis | indication | ||
Prevention of Perioperative Infection | indication | ||
Alcoholism | contraindication | 7200002 | |
Blood coagulation disorder | contraindication | 64779008 | DOID:1247 |
Factor II deficiency | contraindication | 73975000 | |
Kidney disease | contraindication | 90708001 | DOID:557 |
Pseudomembranous enterocolitis | contraindication | 397683000 |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 2.63 | acidic |
pKa2 | 11.72 | acidic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Solute carrier family 15 member 1 | Transporter | Ki | 2.09 | WOMBAT-PK |
ID | Source |
---|---|
4019658 | VUID |
N0000147750 | NUI |
D02344 | KEGG_DRUG |
2178 | RXNORM |
C0007541 | UMLSCUI |
CHEBI:3480 | CHEBI |
CHEMBL1146 | ChEMBL_ID |
D002435 | MESH_DESCRIPTOR_UI |
DB01326 | DRUGBANK_ID |
12210 | IUPHAR_LIGAND_ID |
3329 | INN_ID |
5CKP8C2LLI | UNII |
456255 | PUBCHEM_CID |
d00062 | MMSL |
372801003 | SNOMEDCT_US |
61651006 | SNOMEDCT_US |
SMX | PDB_CHEM_ID |
XD2 | PDB_CHEM_ID |
4019658 | VANDF |
004844 | NDDF |
None