elobixibat 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
ileal bile acid transporter (IBAT) inhibitors, bile acid reabsorption inhibitors 5277 439087-18-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • elobixibat
  • elobixibat hydrate
  • A3309
  • AZD7806
  • AJG533
  • goofice
Elobixibat is an IBAT inhibitor approved in Japan for the treatment of chronic constipation. IBAT is the bile acid/sodium symporter responsible for the reuptake of bile acids in the ileum which is the initial step in the enterohepatic circulation. By inhibiting the uptake of bile acids, elobixibat increases the bile acid concentration in the gut, and this accelerates intestinal passage and softens the stool.
  • Molecular weight: 695.89
  • Formula: C36H45N3O7S2
  • CLOGP: 7.71
  • LIPINSKI: 2
  • HAC: 10
  • HDO: 3
  • TPSA: 142.11
  • ALOGS: -6.37
  • ROTB: 16

Drug dosage:

None

ADMET properties:

None

Approvals:

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

FDA Adverse Event Reporting System (Geriatric)

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Drug Use | Suggest Off label Use Form| |View source of the data|




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

External reference:

Pharmaceutical products:

None

elobixibat