Stem definition | Drug id | CAS RN |
---|---|---|
growth hormone release-stimulating peptides | 5271 | 381231-18-1 |
None
None
Date | Agency | Company | Orphan |
---|---|---|---|
Jan. 11, 2019 | EMA | AETERNA ZENTARIS GMBH | |
Dec. 20, 2017 | FDA | AETERNA ZENTARIS GMBH |
None
None
None
None
Source | Code | Description |
---|---|---|
ATC | V04CD06 | VARIOUS DIAGNOSTIC AGENTS OTHER DIAGNOSTIC AGENTS Tests for pituitary function |
FDA EPC | N0000193785 | Growth Hormone Secretagogue Receptor Agonist |
FDA MoA | N0000193786 | Growth Hormone Secretagogue Receptor Agonists |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Adult growth hormone deficiency | diagnosis | 421684006 |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 12.35 | acidic |
pKa2 | 13.06 | acidic |
pKa3 | 13.84 | acidic |
pKa4 | 7.93 | Basic |
Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Patent number | Patent expiration date | Patent use |
---|---|---|---|---|---|---|---|---|---|---|
EQ 60MG BASE/POUCH | MACRILEN | NOVO | N205598 | Dec. 20, 2017 | DISCN | FOR SOLUTION | ORAL | 8192719 | Oct. 12, 2027 | A METHOD FOR THE DIAGNOSIS OF ADULT GROWTH HORMONE DEFICIENCY BY MEASURING THE LEVEL OF GROWTH HORMONE AFTER ORAL ADMINISTRATION OF MACIMORELIN |
Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Exclusivity date | Description |
---|---|---|---|---|---|---|---|---|---|
EQ 60MG BASE/POUCH | MACRILEN | NOVO | N205598 | Dec. 20, 2017 | DISCN | FOR SOLUTION | ORAL | Dec. 20, 2024 | FOR THE DIAGNOSIS OF ADULT GROWTH HORMONE DEFICIENCY (AGHD) |
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Growth hormone secretagogue receptor type 1 | GPCR | AGONIST | IC50 | 7.81 | IUPHAR | DRUG LABEL |
ID | Source |
---|---|
8680B21W73 | UNII |
945212-59-9 | SECONDARY_CAS_RN |
C2986922 | UMLSCUI |
CHEMBL278623 | ChEMBL_ID |
9804938 | PUBCHEM_CID |
DB13074 | DRUGBANK_ID |
CHEMBL2364617 | ChEMBL_ID |
D10563 | KEGG_DRUG |
9073 | INN_ID |
9745 | IUPHAR_LIGAND_ID |
33368 | MMSL |
d08694 | MMSL |
017443 | NDDF |
017444 | NDDF |
781246008 | SNOMEDCT_US |
781247004 | SNOMEDCT_US |
781266004 | SNOMEDCT_US |
4037714 | VANDF |
1999419 | RXNORM |
C582727 | MESH_SUPPLEMENTAL_RECORD_UI |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Macrilen | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0169-1401 | GRANULE, FOR SOLUTION | 60 mg | ORAL | NDA | 25 sections |
Macrilen | HUMAN PRESCRIPTION DRUG LABEL | 1 | 71090-002 | GRANULE, FOR SOLUTION | 60 mg | ORAL | NDA | 25 sections |