lonoctocog alfa 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
blood factor VIII 5265 1388129-63-2

Description:

MoleculeDescription

Synonyms:

  • lonoctocog alfa
  • afstyla
Lonoctocog alfa is a recombinant human protein that replaces the missing coagulation factor VIII needed for effective hemostasis. Lonoctocog alfa is a single polypeptide chain with a truncated B-domain that allows for a covalent bridge to link the factor VIII heavy and light chains. Lonoctocog alfa has demonstrated a higher VWF affinity relative to full-length rFVIII. VWF stabilizes factor VIII and protects it from degradation. Activated Lonoctocog alfa has an amino acid sequence identical to endogenous FVIIIa.
  • Molecular weight:
  • Formula:
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA:
  • ALOGS:
  • ROTB: None

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Jan. 4, 2017 EMA CSL Behring GmbH
Sept. 27, 2017 PMDA CSL Behring KK

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

None

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Hereditary factor VIII deficiency disease indication 28293008 DOID:12134




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
VQ723R7O8R UNII
C4257011 UMLSCUI
CHEMBL4594603 ChEMBL_ID
DB13998 DRUGBANK_ID
D10818 KEGG_DRUG
9834 INN_ID
242309 MMSL
016883 NDDF
1012961000168107 SNOMEDCT_US
1796377 RXNORM

Pharmaceutical products:

None