latanoprostene bunod 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
nitrogen monoxide (nitric oxide, NO) donors 5261 860005-21-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • latanoprostene bunod
  • NCX 116
  • BOL-303259-X
  • PF-3187207
  • vyzulta
Latanoprostene bunod is thought to lower intraocular pressure by increasing outflow of aqueous humor through both the trabecular meshwork and uveoscleral routes. Intraocular pressure is a major modifiable risk factor for glaucoma progression. Reduction of intraocular pressure reduces risk of glaucomatous visual field loss.
  • Molecular weight: 507.62
  • Formula: C27H41NO8
  • CLOGP: 3.70
  • LIPINSKI: 1
  • HAC: 9
  • HDO: 3
  • TPSA: 139.36
  • ALOGS: -5.20
  • ROTB: 19
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

FDA Adverse Event Reporting System (Female)

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Drug Use | Suggest Off label Use Form| |View source of the data|




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

External reference:

Pharmaceutical products:

latanoprostene bunod