imrecoxib 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
selective cyclo-oxygenase inhibitors 5250 395683-14-4

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • imrecoxib
  • BAP-909
Imrecoxib is a selective cyclooxygenase-2 (COX-2) inhibitor indicated for treatment of osteoarthritis.
  • Molecular weight: 369.48
  • Formula: C21H23NO3S
  • CLOGP: 2.71
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 0
  • TPSA: 54.45
  • ALOGS: -4.84
  • ROTB: 5

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
May 20, 2011 China Food and Drug Administration (CFDA) HengRui

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

None

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Osteoarthritis indication 396275006




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Prostaglandin G/H synthase 2 Enzyme INHIBITOR IC50 7.82 SCIENTIFIC LITERATURE SCIENTIFIC LITERATURE
Prostaglandin G/H synthase 2 Enzyme IC50 7.75 CHEMBL
Prostaglandin G/H synthase 1 Enzyme IC50 6.94 CHEMBL

External reference:

IDSource
SGW6W5758V UNII
C1505698 UMLSCUI
CHEMBL504535 ChEMBL_ID
11682175 PUBCHEM_CID
DB12354 DRUGBANK_ID
C488833 MESH_SUPPLEMENTAL_RECORD_UI

Pharmaceutical products:

None