cefacetrile 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| antibiotics, cefalosporanic acid derivatives | 524 | 10206-21-0 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A derivative of 7-aminocephalosporanic acid.
|
Drug dosage:
None
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| MRTD (Maximum Recommended Therapeutic Daily Dose) | 505.20 µM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
| BA (Bioavailability) | 0 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
| Vd (Volume of distribution) | 0.49 L/kg | Lombardo F, Berellini G, Obach RS |
| CL (Clearance) | 3.69 mL/min/kg | Lombardo F, Berellini G, Obach RS |
| t_half (Half-life) | 2.02 hours | Lombardo F, Berellini G, Obach RS |
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | J01DB10 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIBACTERIALS FOR SYSTEMIC USE OTHER BETA-LACTAM ANTIBACTERIALS First-generation cephalosporins |
| MeSH PA | D000900 | Anti-Bacterial Agents |
| MeSH PA | D000890 | Anti-Infective Agents |
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 2.39 | acidic |
| pKa2 | 12.47 | acidic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Penicillin-binding protein 1A | Enzyme | WOMBAT-PK |
External reference:
| ID | Source |
|---|---|
| D01262 | KEGG_DRUG |
| C0007714 | UMLSCUI |
| CHEBI:31364 | CHEBI |
| CHEMBL2110602 | ChEMBL_ID |
| CHEMBL2104099 | ChEMBL_ID |
| DB01414 | DRUGBANK_ID |
| 91562 | PUBCHEM_CID |
| 12192 | IUPHAR_LIGAND_ID |
| D002505 | MESH_DESCRIPTOR_UI |
| 3007 | INN_ID |
| FDM21QQ344 | UNII |
| 005968 | NDDF |
Pharmaceutical products:
None