| Stem definition | Drug id | CAS RN |
|---|---|---|
| humanized origin | 5223 | 637334-45-3 |
| Molecule | Description |
|---|---|
|
Synonyms:
|
The precise mechanism by which ocrelizumab exerts its therapeutic effects in multiple sclerosis is unknown, but is presumed to involve binding to CD20, a cell surface antigen present on pre-B and mature B lymphocytes. Following cell surface binding to B lymphocytes, ocrelizumab results in antibody-dependent cellular cytolysis and complement-mediated lysis.
|
| Dose | Unit | Route |
|---|---|---|
| 3.29 | mg | P |
None
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Aug. 1, 2018 | EMA | Roche Registration GmbH | |
| March 28, 2017 | FDA | GENENTECH INC |
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| COVID-19 | 5639.69 | 16.26 | 2165 | 32873 | 110938 | 63343046 |
| Multiple sclerosis relapse | 875.08 | 16.26 | 459 | 34579 | 48019 | 63405965 |
| Throat irritation | 779.28 | 16.26 | 391 | 34647 | 37256 | 63416728 |
| Urinary tract infection | 623.35 | 16.26 | 747 | 34291 | 263937 | 63190047 |
| Infusion related reaction | 542.11 | 16.26 | 671 | 34367 | 244850 | 63209134 |
| Multiple sclerosis | 509.56 | 16.26 | 255 | 34783 | 24117 | 63429867 |
| SARS-CoV-2 test positive | 468.93 | 16.26 | 174 | 34864 | 7882 | 63446102 |
| Herpes zoster | 431.48 | 16.26 | 360 | 34678 | 82102 | 63371882 |
| COVID-19 pneumonia | 348.92 | 16.26 | 166 | 34872 | 14043 | 63439941 |
| Oral herpes | 320.31 | 16.26 | 192 | 34846 | 25882 | 63428102 |
| JC polyomavirus test positive | 307.64 | 16.26 | 84 | 34954 | 1369 | 63452615 |
| B-lymphocyte count decreased | 263.39 | 16.26 | 70 | 34968 | 1024 | 63452960 |
| Coronavirus infection | 254.80 | 16.26 | 94 | 34944 | 4184 | 63449800 |
| Ear pruritus | 217.42 | 16.26 | 82 | 34956 | 3883 | 63450101 |
| Maternal exposure before pregnancy | 202.58 | 16.26 | 94 | 34944 | 7509 | 63446475 |
| Breast cancer | 198.22 | 16.26 | 184 | 34854 | 48199 | 63405785 |
| No adverse event | 192.31 | 16.26 | 169 | 34869 | 41236 | 63412748 |
| Influenza | 180.35 | 16.26 | 259 | 34779 | 108463 | 63345521 |
| SARS-CoV-2 antibody test negative | 162.87 | 16.26 | 34 | 35004 | 155 | 63453829 |
| Muscle spasticity | 159.08 | 16.26 | 116 | 34922 | 21678 | 63432306 |
| Nasopharyngitis | 146.81 | 16.26 | 387 | 34651 | 253870 | 63200114 |
| Gait disturbance | 129.08 | 16.26 | 301 | 34737 | 182877 | 63271107 |
| Drug ineffective | 128.75 | 16.26 | 239 | 34799 | 1044526 | 62409458 |
| Herpes virus infection | 127.53 | 16.26 | 62 | 34976 | 5494 | 63448490 |
| Rheumatoid arthritis | 122.12 | 16.26 | 4 | 35034 | 253815 | 63200169 |
| Toxicity to various agents | 118.58 | 16.26 | 4 | 35034 | 247246 | 63206738 |
| Fatigue | 116.27 | 16.26 | 861 | 34177 | 887167 | 62566817 |
| Joint swelling | 114.98 | 16.26 | 21 | 35017 | 327645 | 63126339 |
| Oropharyngeal pain | 113.32 | 16.26 | 194 | 34844 | 94293 | 63359691 |
| Relapsing multiple sclerosis | 111.70 | 16.26 | 25 | 35013 | 167 | 63453817 |
| Muscular weakness | 108.90 | 16.26 | 221 | 34817 | 122132 | 63331852 |
| Lymphopenia | 108.27 | 16.26 | 86 | 34952 | 18241 | 63435743 |
| Hypoaesthesia | 103.94 | 16.26 | 263 | 34775 | 168130 | 63285854 |
| Magnetic resonance imaging abnormal | 100.82 | 16.26 | 44 | 34994 | 3041 | 63450943 |
| Optic neuritis | 93 | 16.26 | 58 | 34980 | 8377 | 63445607 |
| Genital herpes | 91.60 | 16.26 | 35 | 35003 | 1717 | 63452267 |
| Throat tightness | 91.13 | 16.26 | 89 | 34949 | 24798 | 63429186 |
| Product use issue | 86.89 | 16.26 | 10 | 35028 | 220510 | 63233474 |
| Systemic lupus erythematosus | 86.12 | 16.26 | 8 | 35030 | 208910 | 63245074 |
| Glossodynia | 85.37 | 16.26 | 3 | 35035 | 178873 | 63275111 |
| Pregnancy | 82.94 | 16.26 | 102 | 34936 | 36734 | 63417250 |
| Invasive ductal breast carcinoma | 82.20 | 16.26 | 50 | 34988 | 6908 | 63447076 |
| Acute kidney injury | 76.57 | 16.26 | 25 | 35013 | 263390 | 63190594 |
| Blood immunoglobulin M decreased | 75.03 | 16.26 | 26 | 35012 | 962 | 63453022 |
| Abdominal discomfort | 73.48 | 16.26 | 43 | 34995 | 320842 | 63133142 |
| Exposure during pregnancy | 72.88 | 16.26 | 3 | 35035 | 155544 | 63298440 |
| Cystitis noninfective | 70.82 | 16.26 | 25 | 35013 | 978 | 63453006 |
| Arthropathy | 70.53 | 16.26 | 21 | 35017 | 234771 | 63219213 |
| Neuralgia | 70.35 | 16.26 | 79 | 34959 | 25847 | 63428137 |
| Product dose omission issue | 70.31 | 16.26 | 21 | 35017 | 234292 | 63219692 |
| Cystitis | 66.00 | 16.26 | 113 | 34925 | 54878 | 63399106 |
| Condition aggravated | 64.82 | 16.26 | 76 | 34962 | 402141 | 63051843 |
| Diarrhoea | 64.26 | 16.26 | 193 | 34845 | 715173 | 62738811 |
| Treatment failure | 63.15 | 16.26 | 16 | 35022 | 199027 | 63254957 |
| Balance disorder | 62.97 | 16.26 | 142 | 34896 | 84280 | 63369704 |
| Papilloma viral infection | 59.93 | 16.26 | 25 | 35013 | 1545 | 63452439 |
| Injection site pain | 56.16 | 16.26 | 4 | 35034 | 129796 | 63324188 |
| Swelling | 56.13 | 16.26 | 42 | 34996 | 275336 | 63178648 |
| Cough | 55.89 | 16.26 | 313 | 34725 | 292430 | 63161554 |
| Anaemia | 54.55 | 16.26 | 49 | 34989 | 293381 | 63160603 |
| Memory impairment | 54.30 | 16.26 | 153 | 34885 | 104105 | 63349879 |
| Drug interaction | 53.43 | 16.26 | 30 | 35008 | 229101 | 63224883 |
| Hepatic enzyme increased | 52.43 | 16.26 | 23 | 35015 | 202305 | 63251679 |
| Drug intolerance | 52.23 | 16.26 | 56 | 34982 | 308605 | 63145379 |
| Blood immunoglobulin G decreased | 52.15 | 16.26 | 26 | 35012 | 2432 | 63451552 |
| Asthenia | 52.07 | 16.26 | 376 | 34662 | 383228 | 63070756 |
| Hemiparesis | 51.65 | 16.26 | 64 | 34974 | 23218 | 63430766 |
| Paraesthesia | 50.84 | 16.26 | 196 | 34842 | 156770 | 63297214 |
| Thrombocytopenia | 50.21 | 16.26 | 11 | 35027 | 151146 | 63302838 |
| Wound | 50.12 | 16.26 | 14 | 35024 | 163249 | 63290735 |
| Lymphocyte count decreased | 49.96 | 16.26 | 72 | 34966 | 30185 | 63423799 |
| Urinary incontinence | 49.71 | 16.26 | 74 | 34964 | 31940 | 63422044 |
| Pericarditis | 49.30 | 16.26 | 7 | 35031 | 131572 | 63322412 |
| Flushing | 49.12 | 16.26 | 120 | 34918 | 74967 | 63379017 |
| Sensory disturbance | 48.38 | 16.26 | 48 | 34990 | 13624 | 63440360 |
| Pruritus | 47.15 | 16.26 | 351 | 34687 | 361102 | 63092882 |
| Product use in unapproved indication | 46.97 | 16.26 | 20 | 35018 | 179060 | 63274924 |
| General physical health deterioration | 46.04 | 16.26 | 27 | 35011 | 201375 | 63252609 |
| Abdominal pain | 45.59 | 16.26 | 57 | 34981 | 293399 | 63160585 |
| Therapeutic product effect decreased | 42.62 | 16.26 | 27 | 35011 | 193160 | 63260824 |
| Suspected COVID-19 | 42.57 | 16.26 | 23 | 35015 | 2539 | 63451445 |
| Headache | 42.37 | 16.26 | 534 | 34504 | 632707 | 62821277 |
| Decreased vibratory sense | 42.32 | 16.26 | 13 | 35025 | 326 | 63453658 |
| Haemoglobin decreased | 41.90 | 16.26 | 14 | 35024 | 145471 | 63308513 |
| Therapeutic product effect incomplete | 41.73 | 16.26 | 9 | 35029 | 125047 | 63328937 |
| Drug hypersensitivity | 41.66 | 16.26 | 67 | 34971 | 310620 | 63143364 |
| Maternal exposure timing unspecified | 39.18 | 16.26 | 32 | 35006 | 7055 | 63446929 |
| Feeling hot | 38.99 | 16.26 | 86 | 34952 | 50268 | 63403716 |
| Demyelination | 37.74 | 16.26 | 31 | 35007 | 6889 | 63447095 |
| Pharyngeal swelling | 37.71 | 16.26 | 30 | 35008 | 6374 | 63447610 |
| Blood creatinine increased | 37.16 | 16.26 | 3 | 35035 | 87841 | 63366143 |
| Vomiting | 37.02 | 16.26 | 171 | 34867 | 559446 | 62894538 |
| Pyelonephritis | 36.46 | 16.26 | 47 | 34991 | 17731 | 63436253 |
| Psoriatic arthropathy | 36.40 | 16.26 | 4 | 35034 | 91516 | 63362468 |
| Arthralgia | 35.99 | 16.26 | 177 | 34861 | 569533 | 62884451 |
| Upper respiratory tract infection | 35.69 | 16.26 | 113 | 34925 | 81934 | 63372050 |
| Platelet count decreased | 35.55 | 16.26 | 10 | 35028 | 116112 | 63337872 |
| Muscle spasms | 35.26 | 16.26 | 175 | 34863 | 155975 | 63298009 |
| B-lymphocyte count increased | 35.13 | 16.26 | 9 | 35029 | 113 | 63453871 |
| Helicobacter infection | 34.60 | 16.26 | 5 | 35033 | 92780 | 63361204 |
| Rhinorrhoea | 33.90 | 16.26 | 96 | 34942 | 65481 | 63388503 |
| Hypokalaemia | 33.57 | 16.26 | 8 | 35030 | 103796 | 63350188 |
| Varicella virus test positive | 32.76 | 16.26 | 9 | 35029 | 150 | 63453834 |
| Renal impairment | 32.40 | 16.26 | 5 | 35033 | 88350 | 63365634 |
| Intentional product use issue | 32.25 | 16.26 | 148 | 34890 | 127744 | 63326240 |
| Cardiac failure congestive | 32.20 | 16.26 | 6 | 35032 | 92427 | 63361557 |
| Injection site erythema | 32.17 | 16.26 | 4 | 35034 | 83170 | 63370814 |
| Tandem gait test abnormal | 31.78 | 16.26 | 7 | 35031 | 43 | 63453941 |
| Immunodeficiency | 31.70 | 16.26 | 47 | 34991 | 20207 | 63433777 |
| Overdose | 31.55 | 16.26 | 12 | 35026 | 115066 | 63338918 |
| Oedema peripheral | 31.34 | 16.26 | 35 | 35003 | 189476 | 63264508 |
| Gastrointestinal haemorrhage | 31.16 | 16.26 | 4 | 35034 | 81172 | 63372812 |
| Oral pruritus | 31.07 | 16.26 | 18 | 35020 | 2273 | 63451711 |
| Ataxia | 30.89 | 16.26 | 40 | 34998 | 15155 | 63438829 |
| Hypogammaglobulinaemia | 30.80 | 16.26 | 28 | 35010 | 7127 | 63446857 |
| Vitamin D deficiency | 30.51 | 16.26 | 38 | 35000 | 13854 | 63440130 |
| Hyponatraemia | 30.13 | 16.26 | 12 | 35026 | 111888 | 63342096 |
| Influenza like illness | 29.95 | 16.26 | 93 | 34945 | 66731 | 63387253 |
| Neurogenic bladder | 29.83 | 16.26 | 20 | 35018 | 3265 | 63450719 |
| Hepatitis B virus test positive | 29.79 | 16.26 | 9 | 35029 | 213 | 63453771 |
| Vaginal infection | 29.62 | 16.26 | 28 | 35010 | 7490 | 63446494 |
| Illness | 29.55 | 16.26 | 76 | 34962 | 48983 | 63405001 |
| Abortion spontaneous | 29.35 | 16.26 | 74 | 34964 | 47121 | 63406863 |
| Peroneal nerve palsy | 29.22 | 16.26 | 23 | 35015 | 4812 | 63449172 |
| Limb discomfort | 29.20 | 16.26 | 56 | 34982 | 29660 | 63424324 |
| Lobular breast carcinoma in situ | 28.96 | 16.26 | 7 | 35031 | 68 | 63453916 |
| Trigeminal neuralgia | 28.59 | 16.26 | 20 | 35018 | 3499 | 63450485 |
| Human papilloma virus test positive | 28.32 | 16.26 | 11 | 35027 | 564 | 63453420 |
| Gastrointestinal infection | 28.16 | 16.26 | 30 | 35008 | 9251 | 63444733 |
| Severe acute respiratory syndrome | 28.12 | 16.26 | 6 | 35032 | 31 | 63453953 |
| Magnetic resonance imaging head abnormal | 27.79 | 16.26 | 16 | 35022 | 1997 | 63451987 |
| Dehydration | 27.60 | 16.26 | 33 | 35005 | 173321 | 63280663 |
| Micturition urgency | 27.29 | 16.26 | 30 | 35008 | 9581 | 63444403 |
| Arthritis | 27.25 | 16.26 | 15 | 35023 | 115906 | 63338078 |
| Perinatal stroke | 27.03 | 16.26 | 5 | 35033 | 10 | 63453974 |
| Urticaria | 26.90 | 16.26 | 170 | 34868 | 165632 | 63288352 |
| Hospitalisation | 26.65 | 16.26 | 7 | 35031 | 85074 | 63368910 |
| Infection susceptibility increased | 26.27 | 16.26 | 19 | 35019 | 3502 | 63450482 |
| Appendicitis | 25.68 | 16.26 | 27 | 35011 | 8202 | 63445782 |
| Immunoglobulins decreased | 25.46 | 16.26 | 13 | 35025 | 1279 | 63452705 |
| Renal failure | 25.18 | 16.26 | 17 | 35021 | 117635 | 63336349 |
| Blister | 24.91 | 16.26 | 21 | 35017 | 129793 | 63324191 |
| Stomatitis | 24.76 | 16.26 | 24 | 35014 | 138701 | 63315283 |
| Fibromyalgia | 24.47 | 16.26 | 7 | 35031 | 80413 | 63373571 |
| Discomfort | 24.44 | 16.26 | 34 | 35004 | 167340 | 63286644 |
| Peripheral swelling | 24.29 | 16.26 | 71 | 34967 | 265871 | 63188113 |
| Nausea | 24.06 | 16.26 | 330 | 34708 | 854141 | 62599843 |
| Therapeutic response shortened | 23.71 | 16.26 | 31 | 35007 | 11857 | 63442127 |
| Malignant melanoma | 23.25 | 16.26 | 30 | 35008 | 11326 | 63442658 |
| Cervical dysplasia | 23.20 | 16.26 | 17 | 35021 | 3197 | 63450787 |
| Liver injury | 23.18 | 16.26 | 3 | 35035 | 60517 | 63393467 |
| Decreased appetite | 22.95 | 16.26 | 67 | 34971 | 250985 | 63202999 |
| Pneumonia | 22.74 | 16.26 | 366 | 34672 | 456401 | 62997583 |
| Neuropathy peripheral | 22.29 | 16.26 | 18 | 35020 | 113649 | 63340335 |
| Anogenital warts | 22.28 | 16.26 | 9 | 35029 | 512 | 63453472 |
| Ophthalmic herpes zoster | 22.21 | 16.26 | 14 | 35024 | 2059 | 63451925 |
| Bladder disorder | 22.14 | 16.26 | 26 | 35012 | 8920 | 63445064 |
| Cervix carcinoma | 21.78 | 16.26 | 16 | 35022 | 3021 | 63450963 |
| Cardiac failure | 21.74 | 16.26 | 11 | 35027 | 89131 | 63364853 |
| Impaired healing | 21.70 | 16.26 | 15 | 35023 | 102527 | 63351457 |
| Central nervous system lesion | 21.63 | 16.26 | 28 | 35010 | 10607 | 63443377 |
| Magnetic resonance imaging spinal abnormal | 21.35 | 16.26 | 7 | 35031 | 218 | 63453766 |
| Sepsis | 21.22 | 16.26 | 151 | 34887 | 152972 | 63301012 |
| Injury | 21.17 | 16.26 | 7 | 35031 | 73240 | 63380744 |
| Urosepsis | 20.83 | 16.26 | 37 | 35001 | 18487 | 63435497 |
| Immunosuppression | 20.79 | 16.26 | 25 | 35013 | 8789 | 63445195 |
| Kidney infection | 20.74 | 16.26 | 42 | 34996 | 23134 | 63430850 |
| Agranulocytosis | 20.68 | 16.26 | 44 | 34994 | 25090 | 63428894 |
| Cardio-respiratory arrest | 20.65 | 16.26 | 4 | 35034 | 59955 | 63394029 |
| Irritable bowel syndrome | 20.35 | 16.26 | 10 | 35028 | 82402 | 63371582 |
| Pharyngeal disorder | 20.33 | 16.26 | 13 | 35025 | 1960 | 63452024 |
| Nasal herpes | 20.19 | 16.26 | 8 | 35030 | 433 | 63453551 |
| Invasive breast carcinoma | 20.11 | 16.26 | 9 | 35029 | 660 | 63453324 |
| Acquired diaphragmatic eventration | 19.99 | 16.26 | 8 | 35030 | 444 | 63453540 |
| Migraine | 19.99 | 16.26 | 111 | 34927 | 103235 | 63350749 |
| Injection site reaction | 19.96 | 16.26 | 4 | 35034 | 58520 | 63395464 |
| Feeling abnormal | 19.79 | 16.26 | 145 | 34893 | 148247 | 63305737 |
| Liver disorder | 19.77 | 16.26 | 3 | 35035 | 53684 | 63400300 |
| Colitis | 19.44 | 16.26 | 65 | 34973 | 48463 | 63405521 |
| Lipoedema | 19.42 | 16.26 | 7 | 35031 | 291 | 63453693 |
| Pleural effusion | 19.24 | 16.26 | 14 | 35024 | 93196 | 63360788 |
| T-lymphocyte count decreased | 19.02 | 16.26 | 7 | 35031 | 309 | 63453675 |
| Infrapatellar fat pad inflammation | 18.94 | 16.26 | 6 | 35032 | 167 | 63453817 |
| Diplopia | 18.90 | 16.26 | 41 | 34997 | 23687 | 63430297 |
| Respiratory tract infection | 18.83 | 16.26 | 58 | 34980 | 41425 | 63412559 |
| Secondary progressive multiple sclerosis | 18.79 | 16.26 | 11 | 35027 | 1416 | 63452568 |
| Atrial fibrillation | 18.78 | 16.26 | 22 | 35016 | 116614 | 63337370 |
| Vulvovaginal mycotic infection | 18.70 | 16.26 | 19 | 35019 | 5547 | 63448437 |
| Unevaluable event | 18.63 | 16.26 | 3 | 35035 | 51383 | 63402601 |
| Loss of personal independence in daily activities | 18.34 | 16.26 | 16 | 35022 | 97274 | 63356710 |
| Cognitive disorder | 18.29 | 16.26 | 70 | 34968 | 55745 | 63398239 |
| Intercepted product storage error | 18.22 | 16.26 | 5 | 35033 | 83 | 63453901 |
| Candida infection | 18.20 | 16.26 | 45 | 34993 | 28306 | 63425678 |
| Cerebral disorder | 18.10 | 16.26 | 17 | 35021 | 4509 | 63449475 |
| Fungal infection | 18.10 | 16.26 | 53 | 34985 | 36821 | 63417163 |
| B-lymphocyte abnormalities | 18.05 | 16.26 | 5 | 35033 | 86 | 63453898 |
| Ear discomfort | 17.96 | 16.26 | 22 | 35016 | 7884 | 63446100 |
| Intraductal proliferative breast lesion | 17.78 | 16.26 | 14 | 35024 | 2931 | 63451053 |
| Oropharyngeal discomfort | 17.75 | 16.26 | 18 | 35020 | 5242 | 63448742 |
| Invasive lobular breast carcinoma | 17.62 | 16.26 | 9 | 35029 | 886 | 63453098 |
| Product temperature excursion issue | 17.58 | 16.26 | 6 | 35032 | 212 | 63453772 |
| West Nile viral infection | 17.40 | 16.26 | 7 | 35031 | 394 | 63453590 |
| Progressive multifocal leukoencephalopathy | 17.35 | 16.26 | 28 | 35010 | 12943 | 63441041 |
| Automatic bladder | 17.21 | 16.26 | 5 | 35033 | 103 | 63453881 |
| Liver function test abnormal | 17.05 | 16.26 | 3 | 35035 | 48178 | 63405806 |
| Hypotension | 16.98 | 16.26 | 85 | 34953 | 272519 | 63181465 |
| Hypoglycaemia | 16.90 | 16.26 | 6 | 35032 | 60059 | 63393925 |
| Disease progression | 16.87 | 16.26 | 26 | 35012 | 122732 | 63331252 |
| Vulvovaginal candidiasis | 16.85 | 16.26 | 14 | 35024 | 3161 | 63450823 |
| Speech disorder | 16.79 | 16.26 | 55 | 34983 | 40574 | 63413410 |
| Blood pressure systolic increased | 16.67 | 16.26 | 3 | 35035 | 47394 | 63406590 |
| Folliculitis | 16.67 | 16.26 | 9 | 35029 | 70308 | 63383676 |
| Breast abscess | 16.58 | 16.26 | 11 | 35027 | 1765 | 63452219 |
| Borrelia infection | 16.52 | 16.26 | 6 | 35032 | 255 | 63453729 |
| Confusional state | 16.31 | 16.26 | 71 | 34967 | 236309 | 63217675 |
| Pulmonary oedema | 16.29 | 16.26 | 5 | 35033 | 54868 | 63399116 |
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| COVID-19 | 2700.94 | 21.28 | 998 | 10826 | 76552 | 34868555 |
| Multiple sclerosis relapse | 529.52 | 21.28 | 190 | 11634 | 12943 | 34932164 |
| Multiple sclerosis | 380.19 | 21.28 | 125 | 11699 | 6520 | 34938587 |
| Urinary tract infection | 368.60 | 21.28 | 270 | 11554 | 83811 | 34861296 |
| JC polyomavirus test positive | 223.56 | 21.28 | 51 | 11773 | 646 | 34944461 |
| SARS-CoV-2 test positive | 220.80 | 21.28 | 81 | 11743 | 5852 | 34939255 |
| Infusion related reaction | 211.05 | 21.28 | 161 | 11663 | 52896 | 34892211 |
| COVID-19 pneumonia | 183.35 | 21.28 | 97 | 11727 | 16870 | 34928237 |
| Herpes zoster | 153.68 | 21.28 | 112 | 11712 | 34287 | 34910820 |
| Throat irritation | 144.87 | 21.28 | 71 | 11753 | 10514 | 34934593 |
| Nasopharyngitis | 115.60 | 21.28 | 130 | 11694 | 69838 | 34875269 |
| Influenza | 111.99 | 21.28 | 109 | 11715 | 49557 | 34895550 |
| Muscular weakness | 107.92 | 21.28 | 128 | 11696 | 72769 | 34872338 |
| Gait disturbance | 92.16 | 21.28 | 128 | 11696 | 85012 | 34860095 |
| SARS-CoV-2 antibody test negative | 82.20 | 21.28 | 14 | 11810 | 29 | 34945078 |
| Urosepsis | 81.69 | 21.28 | 52 | 11772 | 12747 | 34932360 |
| Magnetic resonance imaging abnormal | 78.23 | 21.28 | 27 | 11797 | 1629 | 34943478 |
| Balance disorder | 66.14 | 21.28 | 75 | 11749 | 40579 | 34904528 |
| Acute kidney injury | 65.70 | 21.28 | 12 | 11812 | 304976 | 34640131 |
| Pruritus | 63.65 | 21.28 | 145 | 11679 | 141836 | 34803271 |
| Blood immunoglobulin M decreased | 62.10 | 21.28 | 17 | 11807 | 467 | 34944640 |
| B-lymphocyte count decreased | 61.72 | 21.28 | 18 | 11806 | 625 | 34944482 |
| Coronavirus infection | 59.23 | 21.28 | 29 | 11795 | 4278 | 34940829 |
| Ear pruritus | 56.73 | 21.28 | 15 | 11809 | 360 | 34944747 |
| No adverse event | 56.71 | 21.28 | 53 | 11771 | 22874 | 34922233 |
| Toxicity to various agents | 55.60 | 21.28 | 3 | 11821 | 200359 | 34744748 |
| Blood immunoglobulin G decreased | 54.36 | 21.28 | 20 | 11804 | 1453 | 34943654 |
| Lymphopenia | 52.88 | 21.28 | 44 | 11780 | 16291 | 34928816 |
| Muscle spasticity | 50.70 | 21.28 | 29 | 11795 | 5859 | 34939248 |
| Oral herpes | 49.59 | 21.28 | 28 | 11796 | 5519 | 34939588 |
| Cystitis | 46.30 | 21.28 | 33 | 11791 | 9732 | 34935375 |
| Anaemia | 44.51 | 21.28 | 12 | 11812 | 233323 | 34711784 |
| Fatigue | 44.45 | 21.28 | 244 | 11580 | 370409 | 34574698 |
| Drug interaction | 44.28 | 21.28 | 11 | 11813 | 225935 | 34719172 |
| Hypoaesthesia | 39.61 | 21.28 | 73 | 11751 | 61371 | 34883736 |
| Diarrhoea | 37.75 | 21.28 | 46 | 11778 | 389866 | 34555241 |
| Breast cancer | 36.38 | 21.28 | 10 | 11814 | 279 | 34944828 |
| Infection | 35.41 | 21.28 | 88 | 11736 | 90827 | 34854280 |
| Antibody test negative | 35.04 | 21.28 | 6 | 11818 | 13 | 34945094 |
| Urinary incontinence | 34.44 | 21.28 | 37 | 11787 | 18837 | 34926270 |
| Cellulitis | 32.98 | 21.28 | 62 | 11762 | 52889 | 34892218 |
| Urticaria | 32.77 | 21.28 | 68 | 11756 | 62309 | 34882798 |
| Sensory disturbance | 31.90 | 21.28 | 22 | 11802 | 6155 | 34938952 |
| B-lymphocyte count increased | 30.44 | 21.28 | 6 | 11818 | 35 | 34945072 |
| Asthenia | 30.33 | 21.28 | 163 | 11661 | 245088 | 34700019 |
| Memory impairment | 29.86 | 21.28 | 53 | 11771 | 43265 | 34901842 |
| Thrombocytopenia | 29.83 | 21.28 | 8 | 11816 | 156239 | 34788868 |
| Vaccination failure | 29.59 | 21.28 | 12 | 11812 | 1134 | 34943973 |
| Mobility decreased | 29.15 | 21.28 | 43 | 11781 | 30085 | 34915022 |
| Relapsing multiple sclerosis | 27.97 | 21.28 | 4 | 11820 | 0 | 34945107 |
| Progressive multiple sclerosis | 27.96 | 21.28 | 8 | 11816 | 259 | 34944848 |
| Haemoglobin decreased | 27.61 | 21.28 | 4 | 11820 | 120768 | 34824339 |
| Disability | 27.06 | 21.28 | 18 | 11806 | 4747 | 34940360 |
| Product use in unapproved indication | 26.61 | 21.28 | 4 | 11820 | 117495 | 34827612 |
| Fall | 26.54 | 21.28 | 137 | 11687 | 202748 | 34742359 |
| Decreased appetite | 25.82 | 21.28 | 12 | 11812 | 166380 | 34778727 |
| Demyelination | 25.43 | 21.28 | 15 | 11809 | 3206 | 34941901 |
| Migraine | 24.66 | 21.28 | 30 | 11794 | 17448 | 34927659 |
| Oropharyngeal pain | 23.92 | 21.28 | 43 | 11781 | 35442 | 34909665 |
| Hemiparesis | 23.77 | 21.28 | 28 | 11796 | 15750 | 34929357 |
| Rectal polyp | 23.75 | 21.28 | 9 | 11815 | 710 | 34944397 |
| Intentional product use issue | 23.38 | 21.28 | 58 | 11766 | 59758 | 34885349 |
| Immunoglobulins decreased | 23.18 | 21.28 | 9 | 11815 | 758 | 34944349 |
| Product dose omission issue | 23.09 | 21.28 | 6 | 11818 | 119705 | 34825402 |
| Neuralgia | 23.07 | 21.28 | 27 | 11797 | 15086 | 34930021 |
| Magnetic resonance imaging spinal abnormal | 22.81 | 21.28 | 6 | 11818 | 141 | 34944966 |
| Dehydration | 22.39 | 21.28 | 8 | 11816 | 129961 | 34815146 |
| Expanded disability status scale score increased | 21.94 | 21.28 | 7 | 11817 | 330 | 34944777 |
| Muscle spasms | 21.59 | 21.28 | 65 | 11759 | 74936 | 34870171 |
| Optic neuritis | 21.51 | 21.28 | 14 | 11810 | 3560 | 34941547 |
| Neurogenic bladder | 21.37 | 21.28 | 11 | 11813 | 1802 | 34943305 |
| Hypogammaglobulinaemia | 21.29 | 21.28 | 19 | 11805 | 7721 | 34937386 |
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| COVID-19 | 5929.81 | 16.60 | 2310 | 32784 | 155364 | 79553930 |
| Multiple sclerosis relapse | 920.36 | 16.60 | 436 | 34658 | 46097 | 79663197 |
| Infusion related reaction | 751.62 | 16.60 | 696 | 34398 | 229541 | 79479753 |
| Throat irritation | 690.06 | 16.60 | 344 | 34750 | 40602 | 79668692 |
| Urinary tract infection | 637.79 | 16.60 | 690 | 34404 | 273822 | 79435472 |
| Multiple sclerosis | 599.62 | 16.60 | 259 | 34835 | 22023 | 79687271 |
| SARS-CoV-2 test positive | 429.80 | 16.60 | 170 | 34924 | 11546 | 79697748 |
| COVID-19 pneumonia | 426.55 | 16.60 | 222 | 34872 | 28627 | 79680667 |
| Herpes zoster | 371.65 | 16.60 | 316 | 34778 | 92767 | 79616527 |
| Coronavirus infection | 296.87 | 16.60 | 115 | 34979 | 7382 | 79701912 |
| Nasopharyngitis | 262.70 | 16.60 | 430 | 34664 | 253451 | 79455843 |
| Oral herpes | 252.89 | 16.60 | 155 | 34939 | 27299 | 79681995 |
| JC polyomavirus test positive | 252.64 | 16.60 | 70 | 35024 | 1532 | 79707762 |
| B-lymphocyte count decreased | 223.97 | 16.60 | 62 | 35032 | 1352 | 79707942 |
| Influenza | 210.59 | 16.60 | 272 | 34822 | 129334 | 79579960 |
| Ear pruritus | 198.74 | 16.60 | 73 | 35021 | 4042 | 79705252 |
| SARS-CoV-2 antibody test negative | 197.93 | 16.60 | 40 | 35054 | 198 | 79709096 |
| Fatigue | 177.53 | 16.60 | 842 | 34252 | 928885 | 78780409 |
| Muscle spasticity | 169.58 | 16.60 | 110 | 34984 | 21365 | 79687929 |
| Gait disturbance | 168.32 | 16.60 | 316 | 34778 | 207190 | 79502104 |
| Maternal exposure before pregnancy | 165.76 | 16.60 | 65 | 35029 | 4308 | 79704986 |
| Breast cancer | 160.47 | 16.60 | 127 | 34967 | 33654 | 79675640 |
| Toxicity to various agents | 156.03 | 16.60 | 7 | 35087 | 421533 | 79287761 |
| Oropharyngeal pain | 144.95 | 16.60 | 208 | 34886 | 109145 | 79600149 |
| Muscular weakness | 139.37 | 16.60 | 252 | 34842 | 160477 | 79548817 |
| Hypoaesthesia | 132.96 | 16.60 | 263 | 34831 | 179089 | 79530205 |
| Acute kidney injury | 132.26 | 16.60 | 33 | 35061 | 519371 | 79189923 |
| Lymphopenia | 110.19 | 16.60 | 98 | 34996 | 30459 | 79678835 |
| Magnetic resonance imaging abnormal | 102.21 | 16.60 | 43 | 35051 | 3416 | 79705878 |
| Herpes virus infection | 94.92 | 16.60 | 51 | 35043 | 6998 | 79702296 |
| Optic neuritis | 90.84 | 16.60 | 55 | 35039 | 9465 | 79699829 |
| Throat tightness | 89.86 | 16.60 | 84 | 35010 | 27823 | 79681471 |
| Drug interaction | 88.54 | 16.60 | 36 | 35058 | 415147 | 79294147 |
| Completed suicide | 87.94 | 16.60 | 5 | 35089 | 245762 | 79463532 |
| Balance disorder | 85.62 | 16.60 | 155 | 34939 | 98702 | 79610592 |
| Relapsing multiple sclerosis | 84.00 | 16.60 | 18 | 35076 | 124 | 79709170 |
| Anaemia | 83.53 | 16.60 | 46 | 35048 | 444969 | 79264325 |
| Drug ineffective | 82.39 | 16.60 | 226 | 34868 | 1080687 | 78628607 |
| Headache | 81.11 | 16.60 | 528 | 34566 | 653244 | 79056050 |
| Sensory disturbance | 81.01 | 16.60 | 61 | 35033 | 15016 | 79694278 |
| Thrombocytopenia | 79.91 | 16.60 | 11 | 35083 | 265248 | 79444046 |
| Condition aggravated | 78.96 | 16.60 | 63 | 35031 | 501061 | 79208233 |
| Pruritus | 77.32 | 16.60 | 361 | 34733 | 394287 | 79315007 |
| Rheumatoid arthritis | 75.32 | 16.60 | 4 | 35090 | 208466 | 79500828 |
| Invasive ductal breast carcinoma | 74.81 | 16.60 | 41 | 35053 | 5851 | 79703443 |
| Memory impairment | 74.60 | 16.60 | 157 | 34937 | 111577 | 79597717 |
| Cystitis | 73.80 | 16.60 | 103 | 34991 | 52629 | 79656665 |
| Genital herpes | 72.09 | 16.60 | 29 | 35065 | 2055 | 79707239 |
| Product dose omission issue | 70.60 | 16.60 | 12 | 35082 | 247525 | 79461769 |
| Blood immunoglobulin M decreased | 69.85 | 16.60 | 25 | 35069 | 1284 | 79708010 |
| Cystitis noninfective | 69.27 | 16.60 | 25 | 35069 | 1315 | 79707979 |
| Diarrhoea | 66.30 | 16.60 | 185 | 34909 | 880304 | 78828990 |
| Neuralgia | 65.30 | 16.60 | 77 | 35017 | 33307 | 79675987 |
| Joint swelling | 64.88 | 16.60 | 23 | 35071 | 288623 | 79420671 |
| Product use issue | 64.87 | 16.60 | 8 | 35086 | 209814 | 79499480 |
| Asthenia | 63.19 | 16.60 | 413 | 34681 | 511276 | 79198018 |
| Product use in unapproved indication | 61.53 | 16.60 | 17 | 35077 | 250342 | 79458952 |
| Haemoglobin decreased | 60.69 | 16.60 | 12 | 35082 | 222107 | 79487187 |
| Urinary incontinence | 60.39 | 16.60 | 82 | 35012 | 40827 | 79668467 |
| Urosepsis | 60.11 | 16.60 | 66 | 35028 | 26429 | 79682865 |
| Cough | 58.03 | 16.60 | 316 | 34778 | 366473 | 79342821 |
| Paraesthesia | 54.37 | 16.60 | 186 | 34908 | 176137 | 79533157 |
| Influenza like illness | 54.07 | 16.60 | 106 | 34988 | 71601 | 79637693 |
| Treatment failure | 53.94 | 16.60 | 6 | 35088 | 170480 | 79538814 |
| Upper respiratory tract infection | 53.90 | 16.60 | 122 | 34972 | 91046 | 79618248 |
| Oedema peripheral | 53.53 | 16.60 | 22 | 35072 | 252266 | 79457028 |
| Papilloma viral infection | 52.72 | 16.60 | 22 | 35072 | 1712 | 79707582 |
| Renal impairment | 51.34 | 16.60 | 5 | 35089 | 157778 | 79551516 |
| Blood immunoglobulin G decreased | 49.67 | 16.60 | 26 | 35068 | 3383 | 79705911 |
| Muscle spasms | 48.44 | 16.60 | 178 | 34916 | 174552 | 79534742 |
| Platelet count decreased | 48.23 | 16.60 | 13 | 35081 | 194651 | 79514643 |
| Rhinorrhoea | 47.43 | 16.60 | 104 | 34990 | 75970 | 79633324 |
| Therapeutic product effect incomplete | 47.40 | 16.60 | 4 | 35090 | 141641 | 79567653 |
| Gastrointestinal haemorrhage | 47.23 | 16.60 | 5 | 35089 | 147714 | 79561580 |
| Abdominal pain | 45.54 | 16.60 | 63 | 35031 | 389506 | 79319788 |
| General physical health deterioration | 44.04 | 16.60 | 34 | 35060 | 275204 | 79434090 |
| Injection site pain | 42.54 | 16.60 | 4 | 35090 | 129834 | 79579460 |
| Lymphocyte count decreased | 42.00 | 16.60 | 75 | 35019 | 47214 | 79662080 |
| Drug intolerance | 41.78 | 16.60 | 33 | 35061 | 264086 | 79445208 |
| Feeling hot | 41.09 | 16.60 | 85 | 35009 | 59649 | 79649645 |
| Blood creatinine increased | 41.06 | 16.60 | 9 | 35085 | 155048 | 79554246 |
| Cardiac failure congestive | 40.37 | 16.60 | 7 | 35087 | 142395 | 79566899 |
| Illness | 40.33 | 16.60 | 73 | 35021 | 46438 | 79662856 |
| Hyponatraemia | 40.23 | 16.60 | 14 | 35080 | 177834 | 79531460 |
| Limb discomfort | 39.88 | 16.60 | 60 | 35034 | 32790 | 79676504 |
| Overdose | 39.16 | 16.60 | 16 | 35078 | 184190 | 79525104 |
| Systemic lupus erythematosus | 38.99 | 16.60 | 4 | 35090 | 121145 | 79588149 |
| Immunodeficiency | 38.96 | 16.60 | 48 | 35046 | 21720 | 79687574 |
| Flushing | 38.32 | 16.60 | 105 | 34989 | 88163 | 79621131 |
| Arthropathy | 38.28 | 16.60 | 15 | 35079 | 177096 | 79532198 |
| Hypogammaglobulinaemia | 37.92 | 16.60 | 37 | 35057 | 12914 | 79696380 |
| Migraine | 37.90 | 16.60 | 104 | 34990 | 87389 | 79621905 |
| Trigeminal neuralgia | 37.42 | 16.60 | 22 | 35072 | 3587 | 79705707 |
| Hepatic enzyme increased | 37.01 | 16.60 | 17 | 35077 | 182593 | 79526701 |
| Hypokalaemia | 36.86 | 16.60 | 9 | 35085 | 144031 | 79565263 |
| Vaginal infection | 36.59 | 16.60 | 26 | 35068 | 5854 | 79703440 |
| Hemiparesis | 34.56 | 16.60 | 57 | 35037 | 33676 | 79675618 |
| Dehydration | 34.47 | 16.60 | 35 | 35059 | 248152 | 79461142 |
| Hyperkalaemia | 33.83 | 16.60 | 5 | 35089 | 114393 | 79594901 |
| Oral pruritus | 33.77 | 16.60 | 18 | 35076 | 2430 | 79706864 |
| Decreased appetite | 33.74 | 16.60 | 62 | 35032 | 342356 | 79366938 |
| Peroneal nerve palsy | 33.69 | 16.60 | 25 | 35069 | 6017 | 79703277 |
| Decreased vibratory sense | 32.72 | 16.60 | 12 | 35082 | 661 | 79708633 |
| Visual impairment | 32.70 | 16.60 | 102 | 34992 | 92029 | 79617265 |
| Pharyngeal swelling | 32.38 | 16.60 | 27 | 35067 | 7692 | 79701602 |
| Ophthalmic herpes zoster | 32.22 | 16.60 | 18 | 35076 | 2666 | 79706628 |
| Gastrointestinal infection | 32.18 | 16.60 | 32 | 35062 | 11429 | 79697865 |
| Lobular breast carcinoma in situ | 31.97 | 16.60 | 7 | 35087 | 54 | 79709240 |
| No adverse event | 31.77 | 16.60 | 58 | 35036 | 37134 | 79672160 |
| Cardio-respiratory arrest | 31.50 | 16.60 | 5 | 35089 | 108505 | 79600789 |
| Feeling abnormal | 30.61 | 16.60 | 145 | 34949 | 159054 | 79550240 |
| Malignant melanoma | 30.49 | 16.60 | 35 | 35059 | 14706 | 79694588 |
| Urticaria | 30.20 | 16.60 | 161 | 34933 | 185040 | 79524254 |
| Progressive multifocal leukoencephalopathy | 29.95 | 16.60 | 41 | 35053 | 20559 | 79688735 |
| Fall | 29.91 | 16.60 | 337 | 34757 | 487292 | 79222002 |
| Vaccination failure | 29.50 | 16.60 | 15 | 35079 | 1838 | 79707456 |
| Renal failure | 29.46 | 16.60 | 27 | 35067 | 200941 | 79508353 |
| Neurogenic bladder | 29.43 | 16.60 | 20 | 35074 | 4192 | 79705102 |
| Hypoxia | 29.42 | 16.60 | 5 | 35089 | 103238 | 79606056 |
| Progressive multiple sclerosis | 29.00 | 16.60 | 13 | 35081 | 1204 | 79708090 |
| Therapeutic response shortened | 28.42 | 16.60 | 35 | 35059 | 15828 | 79693466 |
| Immunisation reaction | 28.35 | 16.60 | 10 | 35084 | 492 | 79708802 |
| Death | 28.12 | 16.60 | 141 | 34953 | 566373 | 79142921 |
| Vomiting | 27.50 | 16.60 | 176 | 34918 | 665652 | 79043642 |
| Pyelonephritis | 27.29 | 16.60 | 39 | 35055 | 20349 | 79688945 |
| Secondary progressive multiple sclerosis | 27.29 | 16.60 | 13 | 35081 | 1384 | 79707910 |
| Rhabdomyolysis | 27.27 | 16.60 | 6 | 35088 | 103125 | 79606169 |
| Suspected COVID-19 | 27.09 | 16.60 | 17 | 35077 | 3116 | 79706178 |
| Disease progression | 26.75 | 16.60 | 25 | 35069 | 184337 | 79524957 |
| Intentional product use issue | 26.70 | 16.60 | 135 | 34959 | 151977 | 79557317 |
| Hypoglycaemia | 26.68 | 16.60 | 6 | 35088 | 101588 | 79607706 |
| Magnetic resonance imaging head abnormal | 26.65 | 16.60 | 16 | 35078 | 2710 | 79706584 |
| Abortion spontaneous | 26.46 | 16.60 | 47 | 35047 | 29460 | 79679834 |
| Aspartate aminotransferase increased | 26.44 | 16.60 | 14 | 35080 | 138627 | 79570667 |
| Paraparesis | 26.43 | 16.60 | 18 | 35076 | 3785 | 79705509 |
| Vitamin D deficiency | 26.38 | 16.60 | 32 | 35062 | 14247 | 79695047 |
| Multiple organ dysfunction syndrome | 26.28 | 16.60 | 10 | 35084 | 120236 | 79589058 |
| Atrial fibrillation | 26.25 | 16.60 | 29 | 35065 | 197857 | 79511437 |
| Immunoglobulins decreased | 25.92 | 16.60 | 13 | 35081 | 1547 | 79707747 |
| Severe acute respiratory syndrome | 25.85 | 16.60 | 7 | 35087 | 140 | 79709154 |
| Immunosuppression | 25.81 | 16.60 | 30 | 35064 | 12773 | 79696521 |
| Hypotension | 25.80 | 16.60 | 103 | 34991 | 440214 | 79269080 |
| Cardiac failure | 24.91 | 16.60 | 19 | 35075 | 154823 | 79554471 |
| Bladder disorder | 24.65 | 16.60 | 25 | 35069 | 9140 | 79700154 |
| Depression | 24.27 | 16.60 | 171 | 34923 | 216619 | 79492675 |
| Cervix carcinoma | 24.06 | 16.60 | 14 | 35080 | 2239 | 79707055 |
| Psoriatic arthropathy | 24.03 | 16.60 | 3 | 35091 | 77996 | 79631298 |
| Hospitalisation | 23.89 | 16.60 | 6 | 35088 | 94230 | 79615064 |
| Ascites | 23.05 | 16.60 | 3 | 35091 | 75559 | 79633735 |
| Lipoedema | 23.00 | 16.60 | 7 | 35087 | 215 | 79709079 |
| Drug hypersensitivity | 22.98 | 16.60 | 62 | 35032 | 298854 | 79410440 |
| Vaccination complication | 22.98 | 16.60 | 10 | 35084 | 863 | 79708431 |
| Bronchitis | 22.96 | 16.60 | 116 | 34978 | 130528 | 79578766 |
| Magnetic resonance imaging spinal abnormal | 22.64 | 16.60 | 7 | 35087 | 227 | 79709067 |
| Febrile neutropenia | 22.58 | 16.60 | 42 | 35052 | 230957 | 79478337 |
| Heart rate increased | 22.50 | 16.60 | 109 | 34985 | 120615 | 79588679 |
| Abdominal discomfort | 22.44 | 16.60 | 48 | 35046 | 250679 | 79458615 |
| Borrelia infection | 21.99 | 16.60 | 7 | 35087 | 250 | 79709044 |
| Cervical dysplasia | 21.95 | 16.60 | 13 | 35081 | 2148 | 79707146 |
| Pleural effusion | 21.90 | 16.60 | 19 | 35075 | 145243 | 79564051 |
| Oxygen saturation decreased | 21.85 | 16.60 | 15 | 35079 | 129032 | 79580262 |
| Injection site erythema | 21.82 | 16.60 | 4 | 35090 | 78193 | 79631101 |
| Burning sensation | 21.81 | 16.60 | 66 | 35028 | 58566 | 79650728 |
| Pneumonia | 21.60 | 16.60 | 409 | 34685 | 659837 | 79049457 |
| Alanine aminotransferase increased | 21.36 | 16.60 | 24 | 35070 | 162546 | 79546748 |
| Depressed level of consciousness | 21.19 | 16.60 | 8 | 35086 | 96644 | 79612650 |
| B-lymphocyte count increased | 21.09 | 16.60 | 6 | 35088 | 145 | 79709149 |
| Breast abscess | 20.84 | 16.60 | 11 | 35083 | 1455 | 79707839 |
| Initial insomnia | 20.65 | 16.60 | 20 | 35074 | 6918 | 79702376 |
| Sensory loss | 20.64 | 16.60 | 27 | 35067 | 12964 | 79696330 |
| Infrapatellar fat pad inflammation | 20.28 | 16.60 | 6 | 35088 | 167 | 79709127 |
| Selective IgG subclass deficiency | 20.11 | 16.60 | 4 | 35090 | 18 | 79709276 |
| Central nervous system lesion | 20.03 | 16.60 | 27 | 35067 | 13341 | 79695953 |
| Demyelination | 19.98 | 16.60 | 21 | 35073 | 8002 | 79701292 |
| Hepatic function abnormal | 19.85 | 16.60 | 4 | 35090 | 73103 | 79636191 |
| Swelling | 19.80 | 16.60 | 41 | 35053 | 216670 | 79492624 |
| Liver disorder | 19.58 | 16.60 | 4 | 35090 | 72413 | 79636881 |
| Salpingitis | 19.57 | 16.60 | 6 | 35088 | 189 | 79709105 |
| Anogenital warts | 19.19 | 16.60 | 9 | 35085 | 925 | 79708369 |
| Varicella virus test positive | 19.13 | 16.60 | 6 | 35088 | 204 | 79709090 |
| Electrocardiogram QT prolonged | 18.96 | 16.60 | 8 | 35086 | 90378 | 79618916 |
| Cardiac arrest | 18.93 | 16.60 | 29 | 35065 | 172067 | 79537227 |
| Acquired diaphragmatic eventration | 18.84 | 16.60 | 8 | 35086 | 650 | 79708644 |
| Oedema | 18.82 | 16.60 | 15 | 35079 | 119565 | 79589729 |
| Appendicitis | 18.49 | 16.60 | 33 | 35061 | 20761 | 79688533 |
| Micturition urgency | 18.14 | 16.60 | 25 | 35069 | 12616 | 79696678 |
| Acne pustular | 18.06 | 16.60 | 6 | 35088 | 246 | 79709048 |
| Dyspnoea exertional | 17.80 | 16.60 | 8 | 35086 | 87065 | 79622229 |
| Pericarditis | 17.80 | 16.60 | 12 | 35082 | 104224 | 79605070 |
| Occipital neuralgia | 17.77 | 16.60 | 7 | 35087 | 469 | 79708825 |
| Infection susceptibility increased | 17.68 | 16.60 | 14 | 35080 | 3707 | 79705587 |
| Ataxia | 17.65 | 16.60 | 36 | 35058 | 25003 | 79684291 |
| Hyperpathia | 17.65 | 16.60 | 3 | 35091 | 4 | 79709290 |
| Disability | 17.63 | 16.60 | 29 | 35065 | 17091 | 79692203 |
| Neuropathy peripheral | 17.35 | 16.60 | 22 | 35072 | 141283 | 79568011 |
| Vulvovaginal mycotic infection | 17.17 | 16.60 | 15 | 35079 | 4551 | 79704743 |
| Invasive breast carcinoma | 16.92 | 16.60 | 7 | 35087 | 533 | 79708761 |
| Middle ear inflammation | 16.91 | 16.60 | 4 | 35090 | 45 | 79709249 |
| Respiratory failure | 16.72 | 16.60 | 34 | 35060 | 180877 | 79528417 |
| Interstitial lung disease | 16.65 | 16.60 | 15 | 35079 | 112585 | 79596709 |
| Coma | 16.64 | 16.60 | 12 | 35082 | 100637 | 79608657 |
| Helicobacter infection | 16.62 | 16.60 | 5 | 35089 | 69699 | 79639595 |
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Perinatal stroke | 26.42 | 20.71 | 4 | 10 | 11 | 89767 |
| Source | Code | Description |
|---|---|---|
| ATC | L04AA36 | ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS IMMUNOSUPPRESSANTS IMMUNOSUPPRESSANTS Selective immunosuppressants |
| FDA CS | M0001357 | Antibodies, Monoclonal |
| FDA CS | M0556300 | Antibodies, Monoclonal, Humanized |
| FDA MoA | N0000175078 | CD20-directed Antibody Interactions |
| MeSH PA | D007155 | Immunologic Factors |
| FDA EPC | N0000175657 | CD20-directed Cytolytic Antibody |
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Primary progressive multiple sclerosis | indication | 428700003 | DOID:0050784 |
None
None
None
None
None
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| B-lymphocyte antigen CD20 | Surface antigen | ANTIBODY BINDING | Kd | 9.08 | IUPHAR | DRUG LABEL |
| ID | Source |
|---|---|
| A10SJL62JY | UNII |
| 4036552 | VANDF |
| C1882138 | UMLSCUI |
| CHEMBL2108041 | ChEMBL_ID |
| DB11988 | DRUGBANK_ID |
| D05218 | KEGG_DRUG |
| 8636 | INN_ID |
| 7580 | IUPHAR_LIGAND_ID |
| 254931 | MMSL |
| 32532 | MMSL |
| d08538 | MMSL |
| 017151 | NDDF |
| 733464008 | SNOMEDCT_US |
| 763559000 | SNOMEDCT_US |
| 1876366 | RXNORM |
| C533411 | MESH_SUPPLEMENTAL_RECORD_UI |
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| OCREVUS | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50242-150 | INJECTION | 300 mg | INTRAVENOUS | BLA | 29 sections |
| OCREVUS | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50242-150 | INJECTION | 300 mg | INTRAVENOUS | BLA | 29 sections |
| OCREVUS | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50242-150 | INJECTION | 300 mg | INTRAVENOUS | BLA | 29 sections |