cytisine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 5217 | 485-35-8 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
RN given refers to (R)-isomer; structure
|
Drug dosage:
None
ADMET properties:
None
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| None | Health Canada |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| CHEBI has role | CHEBI:38231 | phytotoxins |
| CHEBI has role | CHEBI:47958 | muscarinic agonists |
| CHEBI has role | CHEBI:76924 | plant metabolites |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Smoking cessation assistance | indication | 384742004 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 8.18 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Neuronal acetylcholine receptor subunit alpha-7 | Ion channel | Ki | 5.85 | CHEMBL | |||||
| Acetylcholine receptor subunit delta | Ion channel | EC50 | 4 | CHEMBL | |||||
| Neuronal acetylcholine receptor subunit alpha-4 | Ion channel | Ki | 9.47 | CHEMBL | |||||
| Neuronal acetylcholine receptor subunit alpha-7 | Ion channel | Ki | 9.05 | CHEMBL | |||||
| Acetylcholine receptor subunit alpha | Ion channel | IC50 | 5.45 | CHEMBL | |||||
| Nicotinic acetylcholine receptor alpha 5 subunit | Ion channel | Ki | 5.91 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| C0056913 | UMLSCUI |
| CHEBI:4055 | CHEBI |
| C5E | PDB_CHEM_ID |
| CHEMBL497939 | ChEMBL_ID |
| 10235 | PUBCHEM_CID |
| DB09028 | DRUGBANK_ID |
| D07770 | KEGG_DRUG |
| 5347 | IUPHAR_LIGAND_ID |
| 76283008 | SNOMEDCT_US |
| 11015 | INN_ID |
| 1723152 | RXNORM |
| C004712 | MESH_SUPPLEMENTAL_RECORD_UI |
| 1ZI8CA9FWW | UNII |
| 53S5U404NU | UNII |
| P2U1EM4JMV | UNII |
Pharmaceutical products:
None