beclabuvir 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
antivirals RNA polymerase (NS5B) inhibitors 5215 958002-33-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • beclabuvir
  • beclabuvir hydrochloride
  • beclabuvir HCl
  • BMS-791325
  • BMS 791325
an NS5B inhibitor and antiviral agent
  • Molecular weight: 659.85
  • Formula: C36H45N5O5S
  • CLOGP: 6.20
  • LIPINSKI: 2
  • HAC: 10
  • HDO: 1
  • TPSA: 104.19
  • ALOGS: -5.19
  • ROTB: 4

Drug dosage:

None

ADMET properties:

PropertyValueReference
Vd (Volume of distribution) 0.50 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 1.33 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.01 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 5.38 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Dec. 19, 2016 PMDA Bristol-Myers Squibb

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC J05AP58 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIVIRALS FOR SYSTEMIC USE
DIRECT ACTING ANTIVIRALS
Antivirals for treatment of HCV infections

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Chronic hepatitis C indication 128302006




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 3.9 acidic
pKa2 8.35 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Potassium voltage-gated channel subfamily H member 2 Ion channel IC50 4.61 CHEMBL
NS5B protein Enzyme IC50 6.72 CHEMBL
RNA-directed RNA polymerase Unclassified IC50 6.72 CHEMBL

External reference:

IDSource
MYW1X5CO9S UNII
958002-36-3 SECONDARY_CAS_RN
C4045497 UMLSCUI
CHEMBL3126842 ChEMBL_ID
56934415 PUBCHEM_CID
DB12225 DRUGBANK_ID
D10611 KEGG_DRUG
CHEMBL3137325 ChEMBL_ID
9899 INN_ID
C587012 MESH_SUPPLEMENTAL_RECORD_UI

Pharmaceutical products:

None