asunaprevir Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
Hepatitis Virus C (HVC) protease inhibitors 4889 630420-16-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • asunaprevir
  • BMS-650032
  • sunvepra
an NS3 protease inhibitor against hepatitis C virus
  • Molecular weight: 748.29
  • Formula: C35H46ClN5O9S
  • CLOGP: 6.31
  • LIPINSKI: 3
  • HAC: 14
  • HDO: 3
  • TPSA: 182.33
  • ALOGS: -5.40
  • ROTB: 13

Drug dosage:

DoseUnitRoute
0.20 g O

ADMET properties:

PropertyValueReference
Vd (Volume of distribution) 2.77 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 11.78 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.01 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 20 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
July 4, 2014 PMDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Liver injury 88.59 49.20 23 517 15978 46669544
Alanine aminotransferase increased 76.62 49.20 31 509 88420 46597102

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Liver injury 63.71 57.80 16 259 12384 29939819

Pharmacologic Action:

SourceCodeDescription
ATC J05AP06 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIVIRALS FOR SYSTEMIC USE
DIRECT ACTING ANTIVIRALS
Antivirals for treatment of HCV infections
ATC J05AP58 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIVIRALS FOR SYSTEMIC USE
DIRECT ACTING ANTIVIRALS
Antivirals for treatment of HCV infections
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D011480 Protease Inhibitors

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Chronic hepatitis C indication 128302006

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 4.1 acidic
pKa2 1.15 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Genome polyprotein Polyprotein INHIBITOR Ki 9.40 SCIENTIFIC LITERATURE SCIENTIFIC LITERATURE

External reference:

IDSource
S9X0KRJ00S UNII
D10093 KEGG_DRUG
C3491974 UMLSCUI
CHEBI:134723 CHEBI
2R9 PDB_CHEM_ID
CHEMBL2105735 ChEMBL_ID
DB11586 DRUGBANK_ID
16076883 PUBCHEM_CID
9472 INN_ID
C571889 MESH_SUPPLEMENTAL_RECORD_UI
10882 IUPHAR_LIGAND_ID
1652103 RXNORM
016060 NDDF
715390003 SNOMEDCT_US

Pharmaceutical products:

None