ribavirin ๐Ÿถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
antivirals 2373 36791-04-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • ribavirin
  • ribamide
  • ribamidil
  • ribavarin
  • tribavirin
A nucleoside antimetabolite antiviral agent that blocks nucleic acid synthesis and is used against both RNA and DNA viruses.
  • Molecular weight: 244.21
  • Formula: C8H12N4O5
  • CLOGP: -2.57
  • LIPINSKI: 0
  • HAC: 9
  • HDO: 4
  • TPSA: 143.72
  • ALOGS: -0.87
  • ROTB: 3

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
6 g Inhal.solution
1 g O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 142 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 17 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 35.10 ยตM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 60 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 14 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 5.20 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 1 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 45 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Dec. 31, 1985 FDA VALEANT PHARM INTL
Nov. 21, 2001 PMDA Schering-Plough

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Anaemia 3410.27 13.14 2687 61055 249769 50291613
Haemoglobin decreased 1000.58 13.14 1002 62740 126214 50415168
White blood cell count decreased 902.26 13.14 911 62831 115811 50425571
Hepatitis C 771.12 13.14 274 63468 4643 50536739
Platelet count decreased 741.35 13.14 766 62976 99960 50441422
Hepatocellular carcinoma 704.16 13.14 206 63536 1793 50539589
Neutrophil count decreased 452.94 13.14 411 63331 45615 50495767
Decreased appetite 349.83 13.14 777 62965 200146 50341236
Jaundice 347.91 13.14 279 63463 26150 50515232
Blood bilirubin increased 338.69 13.14 298 63444 31740 50509642
Rash 334.62 13.14 1257 62485 436214 50105168
Ascites 328.97 13.14 308 63434 35553 50505829
Hyperbilirubinaemia 310.82 13.14 177 63565 9393 50531989
Anal pruritus 301.86 13.14 81 63661 494 50540888
Hepatic cirrhosis 300.74 13.14 217 63525 17360 50524022
Hepatic encephalopathy 299.00 13.14 173 63569 9463 50531919
Dysgeusia 298.45 13.14 303 63439 38613 50502769
Influenza like illness 285.74 13.14 357 63385 57102 50484280
Depression 263.57 13.14 618 63124 164805 50376577
Hepatic failure 263.43 13.14 260 63482 32023 50509359
Anorectal discomfort 260.65 13.14 99 63643 2038 50539344
Haemolytic anaemia 257.31 13.14 155 63587 9137 50532245
Leukopenia 249.40 13.14 363 63379 67165 50474217
Viral load increased 245.54 13.14 81 63661 1082 50540300
Nausea 243.36 13.14 1616 62126 703782 49837600
Fatigue 241.07 13.14 1616 62126 705985 49835397
Asthenia 236.85 13.14 909 62833 318133 50223249
Retinopathy 217.76 13.14 93 63649 2619 50538763
Pruritus 217.00 13.14 816 62926 282752 50258630
Insomnia 202.85 13.14 580 63162 174285 50367097
Drug hypersensitivity 202.57 13.14 36 63706 250974 50290408
Red blood cell count decreased 202.32 13.14 231 63511 33604 50507778
Joint swelling 181.72 13.14 43 63699 245243 50296139
Pancytopenia 180.94 13.14 355 63387 83675 50457707
Thrombocytopenia 166.32 13.14 442 63300 127231 50414151
Hyperuricaemia 164.00 13.14 91 63651 4589 50536793
Contraindicated product administered 161.23 13.14 6 63736 148952 50392430
Rheumatoid arthritis 159.19 13.14 31 63711 202519 50338863
Toxicity to various agents 152.04 13.14 40 63702 212459 50328923
Drug intolerance 146.20 13.14 47 63695 219057 50322325
Vomiting 144.00 13.14 1032 62710 459726 50081656
Therapeutic product effect decreased 139.06 13.14 8 63734 136042 50405340
Completed suicide 137.16 13.14 7 63735 131882 50409500
Hepatitis C RNA increased 136.25 13.14 32 63710 101 50541281
Hepatitis C RNA positive 135.46 13.14 28 63714 37 50541345
Arthropathy 133.21 13.14 20 63722 157886 50383496
Product use issue 133.07 13.14 16 63726 149459 50391923
Proctalgia 127.10 13.14 79 63663 4924 50536458
Peripheral swelling 124.17 13.14 52 63690 205884 50335498
Pyrexia 120.59 13.14 855 62887 379348 50162034
Wound 119.01 13.14 3 63739 105791 50435591
Systemic lupus erythematosus 118.17 13.14 18 63724 140604 50400778
Off label use 114.73 13.14 269 63473 474157 50067225
Hypersensitivity 109.32 13.14 68 63674 215093 50326289
Cryoglobulinaemia 106.45 13.14 34 63708 407 50540975
Dry skin 105.94 13.14 193 63549 42998 50498384
Neutropenia 102.40 13.14 413 63329 147552 50393830
Autoimmune hepatitis 102.36 13.14 81 63661 7438 50533944
Chills 101.70 13.14 310 63432 96377 50445005
Vogt-Koyanagi-Harada disease 101.65 13.14 25 63717 101 50541281
Condition aggravated 99.97 13.14 137 63605 296921 50244461
Weight decreased 95.77 13.14 539 63203 220706 50320676
Pain 88.65 13.14 402 63340 578501 49962881
Hyperthyroidism 88.21 13.14 92 63650 12083 50529299
Irritability 86.79 13.14 140 63602 28286 50513096
Oesophageal varices haemorrhage 84.94 13.14 36 63706 994 50540388
Fall 84.81 13.14 185 63557 334747 50206635
Hepatitis B reactivation 82.62 13.14 44 63698 2043 50539339
Nasopharyngitis 82.44 13.14 73 63669 192854 50348528
Hepatic cancer 81.39 13.14 51 63691 3224 50538158
Genotype drug resistance test positive 81.02 13.14 25 63717 265 50541117
Infection 78.13 13.14 62 63680 172892 50368490
Portal vein thrombosis 77.47 13.14 43 63699 2169 50539213
Retinal exudates 77.20 13.14 30 63712 658 50540724
Porphyria non-acute 76.25 13.14 24 63718 273 50541109
Death 75.72 13.14 188 63554 325191 50216191
Swelling 75.52 13.14 85 63657 200787 50340595
Cutaneous sarcoidosis 74.27 13.14 24 63718 299 50541083
Malignant neoplasm progression 72.80 13.14 3 63739 68121 50473261
Product use in unapproved indication 71.78 13.14 28 63714 115791 50425591
Sinusitis 69.94 13.14 67 63675 170491 50370891
Haemorrhoids 68.19 13.14 101 63641 18952 50522430
Sarcoidosis 68.19 13.14 54 63688 4963 50536419
Drug ineffective 66.82 13.14 686 63056 818647 49722735
Hepatic enzyme increased 66.23 13.14 46 63696 137334 50404048
Retinal haemorrhage 65.92 13.14 51 63691 4530 50536852
Therapeutic product effect incomplete 65.81 13.14 17 63725 91498 50449884
Blood uric acid increased 64.79 13.14 47 63695 3787 50537595
Musculoskeletal stiffness 64.66 13.14 41 63701 128440 50412942
Virologic failure 61.99 13.14 33 63709 1531 50539851
Maternal exposure during pregnancy 60.71 13.14 67 63675 159711 50381671
Abdominal discomfort 58.52 13.14 128 63614 231513 50309869
Impaired healing 58.44 13.14 9 63733 69777 50471605
Varices oesophageal 58.40 13.14 39 63703 2750 50538632
Arthralgia 58.20 13.14 320 63422 438382 50103000
Headache 57.24 13.14 925 62817 505610 50035772
Renal impairment 56.15 13.14 216 63526 75445 50465937
Erythema multiforme 56.12 13.14 63 63679 8987 50532395
Oxygen saturation decreased 55.84 13.14 12 63730 73236 50468146
Discomfort 55.34 13.14 34 63708 108346 50433036
Disease progression 54.90 13.14 26 63716 95840 50445542
Dehydration 54.76 13.14 354 63388 152095 50389287
Osteoarthritis 52.79 13.14 11 63731 68595 50472787
Pericarditis 52.20 13.14 17 63725 78672 50462710
Transfusion 51.43 13.14 72 63670 12833 50528549
Injection site pain 51.12 13.14 39 63703 110985 50430397
Autoimmune thyroiditis 50.41 13.14 38 63704 3247 50538135
Malaise 50.27 13.14 644 63098 334888 50206494
Glossodynia 50.22 13.14 43 63699 115526 50425856
Drug eruption 49.85 13.14 99 63643 23507 50517875
Lower respiratory tract infection 49.82 13.14 29 63713 95172 50446210
Blood cholesterol increased 48.88 13.14 6 63736 55209 50486173
Mobility decreased 48.43 13.14 20 63722 79928 50461454
Exposure via body fluid 47.94 13.14 19 63723 440 50540942
Anger 47.83 13.14 65 63677 11268 50530114
Rheumatoid factor positive 47.82 13.14 4 63738 49855 50491527
Hypertension 47.54 13.14 124 63618 211079 50330303
Intentional product use issue 46.98 13.14 19 63723 76899 50464483
Intentional overdose 46.12 13.14 11 63731 62493 50478889
Dry mouth 45.53 13.14 165 63577 56013 50485369
Toxic skin eruption 45.18 13.14 63 63679 11188 50530194
Drug reaction with eosinophilia and systemic symptoms 44.90 13.14 106 63636 28318 50513064
Hepatic cancer recurrent 44.58 13.14 10 63732 24 50541358
Basedow's disease 44.16 13.14 16 63726 287 50541095
Pain in extremity 43.07 13.14 187 63555 272678 50268704
Peritonitis bacterial 42.63 13.14 40 63702 4621 50536761
Depressive symptom 42.54 13.14 34 63708 3166 50538216
Exposure via father 42.25 13.14 15 63727 253 50541129
Weight increased 42.10 13.14 123 63619 201768 50339614
Liver transplant rejection 41.91 13.14 24 63718 1286 50540096
Psoriatic arthropathy 41.90 13.14 5 63737 47027 50494355
Hypothyroidism 41.20 13.14 115 63627 34010 50507372
Febrile neutropenia 40.44 13.14 38 63704 97629 50443753
Liver transplant 40.33 13.14 28 63714 2104 50539278
Helicobacter infection 40.29 13.14 7 63735 49695 50491687
Flushing 40.21 13.14 17 63725 66998 50474384
Irritable bowel syndrome 40.09 13.14 8 63734 51433 50489949
Rash pruritic 40.02 13.14 142 63600 47704 50493678
Exposure via direct contact 39.52 13.14 12 63730 120 50541262
Loss of personal independence in daily activities 38.59 13.14 20 63722 70030 50471352
Child-Pugh-Turcotte score increased 38.11 13.14 8 63734 12 50541370
Hepatorenal syndrome 38.01 13.14 25 63717 1718 50539664
Drug abuse 37.84 13.14 14 63728 59832 50481550
Tongue pigmentation 36.66 13.14 8 63734 16 50541366
Urticaria 35.74 13.14 68 63674 129493 50411889
Exposure via partner 35.70 13.14 11 63731 116 50541266
Arthritis 35.60 13.14 34 63708 86687 50454695
Hypotension 35.56 13.14 164 63578 235305 50306077
Myalgia 35.44 13.14 273 63469 124046 50417336
Hospitalisation 35.10 13.14 21 63721 67916 50473466
Type 1 diabetes mellitus 34.97 13.14 30 63712 3083 50538299
Bilirubin conjugated increased 34.83 13.14 27 63715 2405 50538977
Yellow skin 34.57 13.14 25 63717 2004 50539378
Hepatic fibrosis 34.24 13.14 30 63712 3172 50538210
Blood pressure increased 34.05 13.14 73 63669 133059 50408323
Blood pressure fluctuation 34.00 13.14 3 63739 35820 50505562
C-reactive protein increased 33.72 13.14 21 63721 66453 50474929
Injury 33.46 13.14 10 63732 48915 50492467
Hepatitis C virus test positive 33.39 13.14 10 63732 95 50541287
Thirst 33.25 13.14 53 63689 10597 50530785
Intentional product misuse 32.98 13.14 9 63733 46725 50494657
Angiotensin converting enzyme increased 32.98 13.14 9 63733 59 50541323
Face oedema 32.03 13.14 70 63672 17769 50523613
Electrocardiogram QT prolonged 31.38 13.14 13 63729 51873 50489509
Aplastic anaemia 30.73 13.14 43 63699 7660 50533722
Ammonia increased 30.63 13.14 32 63710 4209 50537173
Nasal congestion 30.61 13.14 13 63729 51107 50490275
Thyroiditis 30.03 13.14 22 63720 1800 50539582
Encephalopathy 29.88 13.14 102 63640 33609 50507773
Anorectal disorder 29.42 13.14 20 63722 1452 50539930
Paternal drugs affecting foetus 29.37 13.14 8 63734 52 50541330
Haemolysis 29.26 13.14 37 63705 5979 50535403
Neuropathy peripheral 29.19 13.14 48 63694 96709 50444673
Pregnancy of partner 28.72 13.14 7 63735 27 50541355
Gastrointestinal disorder 28.37 13.14 47 63695 94409 50446973
Wheezing 28.29 13.14 22 63720 62025 50479357
Cardiac failure congestive 28.22 13.14 39 63703 84343 50457039
Disturbance in attention 28.20 13.14 95 63647 31091 50510291
Mood swings 27.96 13.14 62 63680 15892 50525490
Viral mutation identified 27.59 13.14 20 63722 1609 50539773
Osteoporosis 27.54 13.14 11 63731 44868 50496514
Urate nephropathy 27.43 13.14 9 63733 118 50541264
Complications of transplanted liver 27.39 13.14 12 63730 360 50541022
Injection site rash 27.38 13.14 62 63680 16115 50525267
Rash papular 26.78 13.14 53 63689 12551 50528831
Gait disturbance 26.67 13.14 98 63644 149907 50391475
Cardiac arrest 26.66 13.14 40 63702 83611 50457771
Blood pressure systolic increased 26.62 13.14 6 63736 35443 50505939
Ocular icterus 26.51 13.14 27 63715 3448 50537934
Anaphylactic reaction 26.16 13.14 18 63724 54037 50487345
Glomerulonephritis 26.09 13.14 19 63723 1540 50539842
Pulmonary embolism 25.81 13.14 56 63686 101648 50439734
Hypersplenism 25.58 13.14 10 63732 223 50541159
Disease recurrence 25.55 13.14 69 63673 20012 50521370
Alcoholism 25.44 13.14 19 63723 1601 50539781
Therapy non-responder 25.18 13.14 129 63613 50893 50490489
Liver transplant failure 24.86 13.14 6 63736 22 50541360
Splenomegaly 24.73 13.14 44 63698 9616 50531766
Glomerulonephritis membranoproliferative 24.66 13.14 9 63733 165 50541217
Full blood count abnormal 24.56 13.14 75 63667 23313 50518069
Coronary artery disease 24.51 13.14 4 63738 29722 50511660
Hepatitis C virus test 24.46 13.14 5 63737 6 50541376
Aplasia pure red cell 23.87 13.14 28 63714 4187 50537195
Subarachnoid haemorrhage 23.73 13.14 46 63696 10730 50530652
Memory impairment 23.01 13.14 175 63567 79185 50462197
Pancreas transplant rejection 22.81 13.14 8 63734 130 50541252
Erythema nodosum 22.22 13.14 26 63716 3877 50537505
Crying 21.94 13.14 66 63676 20350 50521032
Alanine aminotransferase increased 21.90 13.14 188 63554 88171 50453211
Feeling cold 21.80 13.14 64 63678 19467 50521915
Ill-defined disorder 21.76 13.14 22 63720 54632 50486750
Hepatic hydrothorax 21.73 13.14 5 63737 14 50541368
Deep vein thrombosis 21.52 13.14 37 63705 73267 50468115
Inflammation 21.44 13.14 24 63718 56888 50484494
Extradural abscess 21.19 13.14 13 63729 791 50540591
Adverse drug reaction 21.12 13.14 23 63719 55199 50486183
Serotonin syndrome 21.12 13.14 3 63739 24710 50516672
Pain in jaw 21.12 13.14 11 63731 38417 50502965
Surgery 20.97 13.14 6 63736 30199 50511183
Chronic kidney disease 20.96 13.14 12 63730 39759 50501623
Oral mucosal blistering 20.91 13.14 28 63714 4784 50536598
Skin disorder 20.68 13.14 72 63670 23958 50517424
Hepatitis E 20.62 13.14 15 63727 1214 50540168
Haematocrit decreased 20.56 13.14 93 63649 34883 50506499
Maternal exposure before pregnancy 20.50 13.14 30 63712 5567 50535815
Chest discomfort 20.40 13.14 55 63687 92667 50448715
Plasma cell myeloma 20.36 13.14 7 63735 31315 50510067
Sleep apnoea syndrome 20.16 13.14 3 63739 23865 50517517
Hypervolaemia 19.79 13.14 4 63738 25495 50515887
Muscular weakness 19.70 13.14 58 63684 94955 50446427
Emotional disorder 19.63 13.14 45 63697 11791 50529591
Renal failure 19.58 13.14 213 63529 106420 50434962
Suicidal ideation 19.48 13.14 128 63614 55257 50486125
Viral load decreased 19.30 13.14 5 63737 26 50541356
Intentional self-injury 19.30 13.14 3 63739 23109 50518273
Hepatorenal failure 19.16 13.14 11 63731 592 50540790
Hepatopulmonary syndrome 19.06 13.14 4 63738 6 50541376
Blood disorder 19.04 13.14 29 63713 5576 50535806
Contusion 18.83 13.14 75 63667 112108 50429274
Injection site swelling 18.80 13.14 15 63727 41758 50499624
Constipation 18.69 13.14 147 63595 185561 50355821
Type 2 diabetes mellitus 18.65 13.14 10 63732 34365 50507017
Chromaturia 18.43 13.14 50 63692 14540 50526842
Aspartate aminotransferase increased 18.31 13.14 164 63578 77834 50463548
Dermatitis 18.16 13.14 49 63693 14202 50527180
Mental disorder 18.15 13.14 65 63677 21926 50519456
Retinal detachment 18.08 13.14 27 63715 5102 50536280
Liver function test increased 17.94 13.14 5 63737 25601 50515781
Alopecia 17.82 13.14 419 63323 244628 50296754
Overgrowth fungal 17.55 13.14 6 63736 90 50541292
Anti-erythropoietin antibody positive 17.51 13.14 9 63733 388 50540994
Hypophagia 17.26 13.14 75 63667 27653 50513729
Hepatitis cholestatic 17.15 13.14 29 63713 6088 50535294
Rhinorrhoea 17.09 13.14 24 63718 51559 50489823
Hepatitis C RNA decreased 17.04 13.14 3 63739 0 50541382
Hashitoxicosis 17.04 13.14 3 63739 0 50541382
Hepatitis virus-associated nephropathy 17.04 13.14 3 63739 0 50541382
Ocular sarcoidosis 17.04 13.14 5 63737 44 50541338
Miscarriage of partner 17.04 13.14 3 63739 0 50541382
Lymphocyte count decreased 16.89 13.14 6 63736 26301 50515081
Product prescribing error 16.88 13.14 3 63739 20958 50520424
Pneumonia aspiration 16.85 13.14 9 63733 30995 50510387
Gastric varices haemorrhage 16.75 13.14 6 63736 104 50541278
Cerebrovascular accident 16.73 13.14 62 63680 94618 50446764
Facial paralysis 16.49 13.14 44 63698 12671 50528711
Blood bilirubin unconjugated increased 16.38 13.14 8 63734 309 50541073
Hepatitis B 16.35 13.14 21 63721 3445 50537937
Epistaxis 16.33 13.14 137 63605 63817 50477565
Herpes zoster 16.33 13.14 41 63701 70745 50470637
Guillain-Barre syndrome 16.30 13.14 21 63721 3456 50537926
Rhinocerebral mucormycosis 16.29 13.14 7 63735 200 50541182
Paraesthesia 16.26 13.14 87 63655 120156 50421226
Eczema 16.17 13.14 64 63678 22638 50518744
Bursitis 16.12 13.14 4 63738 22131 50519251
Retinal disorder 16.12 13.14 14 63728 1463 50539919
Emotional distress 16.05 13.14 8 63734 28655 50512727
Bronchitis 16.02 13.14 72 63670 104087 50437295
Abortion induced 16.02 13.14 36 63706 9308 50532074
Clostridium difficile infection 16.00 13.14 6 63736 25433 50515949
Anaphylactic shock 15.98 13.14 3 63739 20152 50521230
Respiratory arrest 15.89 13.14 9 63733 30000 50511382
Hemiparesis 15.87 13.14 3 63739 20045 50521337
Device issue 15.78 13.14 3 63739 19969 50521413
VIIIth nerve lesion 15.57 13.14 4 63738 20 50541362
Gingival bleeding 15.45 13.14 40 63702 11313 50530069
Depressed mood 15.40 13.14 84 63658 33939 50507443
Bleeding varicose vein 15.38 13.14 7 63735 230 50541152
Upper respiratory tract infection 15.33 13.14 38 63704 65860 50475522
Portal hypertension 15.15 13.14 20 63722 3372 50538010
Psoriasis 15.12 13.14 41 63701 68959 50472423
Mucosal inflammation 15.04 13.14 17 63725 40125 50501257
Cerebral arteriovenous malformation haemorrhagic 14.96 13.14 3 63739 3 50541379
Limb discomfort 14.89 13.14 6 63736 24351 50517031
Oral candidiasis 14.83 13.14 51 63691 16864 50524518
Hypoxia 14.83 13.14 26 63716 51097 50490285
Blood bilirubin abnormal 14.71 13.14 10 63732 726 50540656
Paranoia 14.64 13.14 37 63705 10311 50531071
Immune thrombocytopenia 14.64 13.14 34 63708 8983 50532399
Blood potassium decreased 14.62 13.14 88 63654 36857 50504525
Congenital tongue anomaly 14.50 13.14 3 63739 4 50541378
Disseminated intravascular coagulation 14.45 13.14 51 63691 17084 50524298
Injection site eczema 14.43 13.14 4 63738 28 50541354
Alopecia universalis 14.33 13.14 5 63737 80 50541302
Joint range of motion decreased 14.17 13.14 3 63739 18509 50522873
Hepatic neoplasm 14.14 13.14 14 63728 1728 50539654
Myocardial infarction 14.02 13.14 61 63681 88966 50452416
Femur fracture 13.89 13.14 16 63726 37448 50503934
Fibromyalgia 13.85 13.14 22 63720 44956 50496426
Syncope 13.82 13.14 194 63548 102808 50438574
Liver injury 13.78 13.14 7 63735 24799 50516583
Oedema due to hepatic disease 13.75 13.14 3 63739 6 50541376
Bronchopulmonary disease 13.75 13.14 3 63739 6 50541376
Psychotic disorder 13.58 13.14 59 63683 21753 50519629
Joint stiffness 13.49 13.14 11 63731 30297 50511085
Blood albumin decreased 13.48 13.14 42 63700 13194 50528188
Throat irritation 13.43 13.14 11 63731 30228 50511154
Portal hypertensive gastropathy 13.27 13.14 9 63733 651 50540731
Chronic hepatic failure 13.25 13.14 8 63734 473 50540909
Cholangitis 13.22 13.14 22 63720 4557 50536825
Lethargy 13.21 13.14 107 63635 49325 50492057
Breast cancer 13.19 13.14 21 63721 42869 50498513
Hypoglycaemia 13.18 13.14 30 63712 53551 50487831
Non-neutralising antibodies positive 13.15 13.14 3 63739 8 50541374

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Anaemia 2466.63 12.13 2933 81265 198018 29292311
Hepatitis C 1771.07 12.13 736 83462 8174 29482155
Hepatocellular carcinoma 1760.52 12.13 686 83512 6352 29483977
Rash 987.34 12.13 1858 82340 187961 29302368
White blood cell count decreased 720.03 12.13 1028 83170 82334 29407995
Hepatic cirrhosis 705.05 12.13 465 83733 13979 29476350
Fatigue 698.38 12.13 2227 81971 314594 29175735
Haemoglobin decreased 633.82 12.13 1118 83080 107257 29383072
Influenza like illness 560.18 12.13 502 83696 23968 29466361
Pruritus 538.51 12.13 1089 83109 115760 29374569
Treatment failure 518.57 12.13 581 83617 36358 29453971
Ascites 514.13 12.13 576 83622 36043 29454286
Insomnia 448.17 12.13 860 83338 87901 29402428
Platelet count decreased 423.10 12.13 925 83273 103747 29386582
Hepatic encephalopathy 420.01 12.13 326 83872 12709 29477620
Genotype drug resistance test positive 401.32 12.13 139 84059 884 29489445
Blood bilirubin increased 395.51 12.13 485 83713 33408 29456921
Depression 386.32 12.13 789 83409 84358 29405971
Anorectal discomfort 377.12 12.13 150 84048 1469 29488860
Retinopathy 348.67 12.13 146 84052 1649 29488680
Anal pruritus 337.59 12.13 93 84105 229 29490100
Dysgeusia 322.06 12.13 359 83839 22315 29468014
Hepatic failure 304.86 12.13 411 83787 31101 29459228
Irritability 294.65 12.13 339 83859 21813 29468516
Death 290.35 12.13 329 83869 341755 29148574
Toxicity to various agents 286.69 12.13 71 84127 173590 29316739
Neutrophil count decreased 286.23 12.13 474 83724 43093 29447236
Hyperbilirubinaemia 275.64 12.13 272 83926 14662 29475667
Hepatic cancer 274.69 12.13 191 84007 6265 29484064
Liver transplant 261.29 12.13 129 84069 2187 29488142
Hyperuricaemia 261.25 12.13 190 84008 6699 29483630
Jaundice 248.86 12.13 359 83839 28937 29461392
Oesophageal varices haemorrhage 236.88 12.13 127 84071 2575 29487754
Viral load increased 236.74 12.13 116 84082 1933 29488396
Headache 232.96 12.13 1046 83152 172961 29317368
Decreased appetite 212.20 12.13 897 83301 144445 29345884
Nausea 195.63 12.13 1449 82749 287806 29202523
Febrile neutropenia 184.83 12.13 46 84152 112194 29378135
Virologic failure 179.84 12.13 108 84090 2739 29487590
Malignant neoplasm progression 179.70 12.13 7 84191 73852 29416477
Leukopenia 178.95 12.13 448 83750 54755 29435574
Hypotension 176.57 12.13 176 84022 194178 29296151
Hepatitis C RNA positive 154.68 12.13 44 84154 127 29490202
Hepatitis C RNA increased 152.94 12.13 49 84149 235 29490094
Retinal exudates 152.30 12.13 61 84137 609 29489720
Drug abuse 149.70 12.13 24 84174 79859 29410470
Proctalgia 147.29 12.13 111 84087 4134 29486195
Fall 140.61 12.13 179 84019 176999 29313330
Dry skin 132.52 12.13 238 83960 23069 29467260
Completed suicide 130.35 12.13 47 84151 90199 29400130
Haemolytic anaemia 123.26 12.13 143 84055 9276 29481053
Haemorrhoids 121.83 12.13 158 84040 11499 29478830
Disease progression 121.16 12.13 41 84157 81875 29408454
Varices oesophageal 117.52 12.13 86 84112 3060 29487269
Peritonitis bacterial 113.98 12.13 109 84089 5647 29484682
Cardiac failure congestive 112.09 12.13 39 84159 76542 29413787
Infusion related reaction 110.84 12.13 3 84195 43883 29446446
Product use in unapproved indication 108.37 12.13 56 84142 86819 29403510
Mood swings 106.67 12.13 117 84081 7134 29483195
Cryoglobulinaemia 105.39 12.13 38 84160 276 29490053
Drug hypersensitivity 105.12 12.13 32 84166 68374 29421955
Acute kidney injury 104.98 12.13 395 83803 264872 29225457
Porphyria non-acute 104.89 12.13 42 84156 419 29489910
Viral mutation identified 104.40 12.13 73 84125 2415 29487914
Off label use 104.07 12.13 472 83726 300328 29190001
Red blood cell count decreased 102.77 12.13 226 83972 25376 29464953
Depressed mood 101.32 12.13 174 84024 16274 29474055
Hepatic cancer recurrent 99.31 12.13 36 84162 266 29490063
Pancytopenia 96.33 12.13 480 83718 82688 29407641
Drug ineffective 95.28 12.13 1505 82693 361665 29128664
Rash pruritic 92.71 12.13 200 83998 22163 29468166
Oxygen saturation decreased 87.62 12.13 12 84186 44925 29445404
Retinal haemorrhage 86.74 12.13 84 84114 4420 29485909
Drug eruption 85.17 12.13 163 84035 16578 29473751
Weight decreased 83.46 12.13 723 83475 150182 29340147
Thrombocytopenia 80.40 12.13 657 83541 134166 29356163
Plasma cell myeloma 79.72 12.13 7 84191 37108 29453221
Atrial fibrillation 79.34 12.13 111 84087 105535 29384794
Asthenia 78.65 12.13 947 83251 214303 29276026
Vogt-Koyanagi-Harada disease 78.51 12.13 22 84176 59 29490270
Blood pressure increased 77.60 12.13 58 84140 73745 29416584
Injection site rash 77.30 12.13 71 84127 3493 29486836
Hepatorenal syndrome 77.13 12.13 59 84139 2247 29488082
Portal hypertension 76.69 12.13 70 84128 3416 29486913
Pneumonia 76.05 12.13 567 83631 319605 29170724
Hepatitis C virus test positive 74.18 12.13 29 84169 270 29490059
Hepatic hydrothorax 70.75 12.13 18 84180 28 29490301
Erythema multiforme 70.54 12.13 98 84100 7619 29482710
Renal impairment 69.82 12.13 433 83765 80900 29409429
Electrocardiogram QT prolonged 69.62 12.13 10 84188 36127 29454202
Therapeutic product effect incomplete 68.86 12.13 14 84184 39291 29451038
Myocardial infarction 68.69 12.13 131 84067 110165 29380164
Hospitalisation 68.00 12.13 23 84175 45965 29444364
Mucosal inflammation 67.75 12.13 6 84192 31589 29458740
Blood uric acid increased 66.31 12.13 82 84116 5686 29484643
Portal vein thrombosis 66.15 12.13 63 84135 3246 29487083
Hepatitis B reactivation 63.65 12.13 61 84137 3168 29487161
General physical health deterioration 62.45 12.13 124 84074 102733 29387596
Coronary artery disease 62.11 12.13 24 84174 44166 29446163
Intentional product misuse 61.44 12.13 12 84186 34649 29455680
Cardiac arrest 61.23 12.13 93 84105 85498 29404831
Bradycardia 61.09 12.13 58 84140 65571 29424758
Peripheral swelling 59.72 12.13 56 84142 63683 29426646
Intentional overdose 59.21 12.13 18 84180 38510 29451819
Injection site erythema 59.20 12.13 126 84072 13830 29476499
Tachycardia 57.47 12.13 73 84125 72337 29417992
Hyperkalaemia 57.44 12.13 54 84144 61338 29428991
Therapy non-responder 56.44 12.13 205 83993 30706 29459623
Foetal exposure during pregnancy 55.44 12.13 14 84184 33853 29456476
Anger 55.35 12.13 106 84092 10784 29479545
Weight increased 55.13 12.13 83 84115 76584 29413745
Liver transplant rejection 54.25 12.13 45 84153 1929 29488400
Suicidal ideation 54.16 12.13 219 83979 34497 29455832
Hypertension 53.93 12.13 162 84036 116452 29373877
Flushing 53.63 12.13 9 84189 28983 29461346
Dry mouth 52.77 12.13 159 84039 21625 29468704
Respiratory failure 51.62 12.13 126 84072 97005 29393324
Hepatitis C RNA 50.60 12.13 12 84186 11 29490318
Cardio-respiratory arrest 50.35 12.13 42 84156 50559 29439770
Intentional product use issue 49.21 12.13 30 84168 42468 29447861
Condition aggravated 48.95 12.13 232 83966 146063 29344266
C-reactive protein increased 47.53 12.13 34 84164 44229 29446100
Hepatic pain 46.92 12.13 34 84164 1191 29489138
Pneumonia aspiration 46.79 12.13 23 84175 36714 29453615
Hypoxia 46.32 12.13 40 84158 47339 29442990
Rheumatoid arthritis 45.95 12.13 17 84181 32135 29458194
Prostate cancer 44.90 12.13 9 84189 25518 29464811
Anaphylactic reaction 43.99 12.13 12 84186 27561 29462768
Neuropathy peripheral 42.77 12.13 86 84112 70941 29419388
Blood bilirubin unconjugated increased 42.72 12.13 24 84174 535 29489794
Malaise 42.53 12.13 664 83534 158938 29331391
Alopecia 42.24 12.13 135 84063 18949 29471380
Blood pressure fluctuation 42.05 12.13 4 84194 19890 29470439
Bleeding varicose vein 41.86 12.13 19 84179 264 29490065
Gastric varices haemorrhage 41.50 12.13 18 84180 223 29490106
Pulmonary embolism 40.88 12.13 99 84099 76435 29413894
Cerebrovascular accident 40.67 12.13 100 84098 76811 29413518
Asthma 40.45 12.13 23 84175 33826 29456503
Viral load 40.44 12.13 12 84186 42 29490287
Pregnancy of partner 39.63 12.13 19 84179 301 29490028
Child-Pugh-Turcotte score increased 39.52 12.13 10 84188 15 29490314
Heart rate decreased 39.44 12.13 11 84187 24901 29465428
Hypersensitivity 39.26 12.13 56 84142 52847 29437482
Yellow skin 39.26 12.13 37 84161 1881 29488448
Focal segmental glomerulosclerosis 39.19 12.13 36 84162 1771 29488558
Joint swelling 38.37 12.13 51 84147 49579 29440750
Cardiac failure 38.19 12.13 108 84090 79179 29411150
Therapeutic product effect decreased 38.18 12.13 18 84180 29433 29460896
Basedow's disease 38.07 12.13 12 84186 54 29490275
Wrong technique in product usage process 38.07 12.13 21 84177 31407 29458922
Contraindicated product administered 37.76 12.13 4 84194 18262 29472067
Skin disorder 37.28 12.13 94 84104 11524 29478805
Disturbance in attention 36.53 12.13 139 84059 21285 29469044
Hyponatraemia 36.50 12.13 87 84111 67546 29422783
Encephalopathy 36.47 12.13 180 84018 30863 29459466
Wheezing 36.38 12.13 25 84173 33215 29457114
Angioedema 36.29 12.13 23 84175 31892 29458437
Osteonecrosis of jaw 35.76 12.13 3 84195 16507 29473822
Sedation 35.50 12.13 4 84194 17401 29472928
Cardiogenic shock 35.39 12.13 6 84192 19184 29471145
Chronic obstructive pulmonary disease 34.92 12.13 39 84159 40916 29449413
Neuroleptic malignant syndrome 34.80 12.13 3 84195 16145 29474184
Abortion spontaneous 34.63 12.13 11 84187 51 29490278
Vomiting 34.56 12.13 819 83379 211441 29278888
Facial paralysis 34.19 12.13 81 84117 9548 29480781
Hypoglycaemia 34.10 12.13 53 84145 48293 29442036
Cardiac disorder 33.43 12.13 34 84164 37229 29453100
Neutropenia 33.19 12.13 543 83655 131168 29359161
Mental disorder 32.97 12.13 96 84102 12809 29477520
Glomerulonephritis membranoproliferative 32.58 12.13 18 84180 388 29489941
Chronic hepatitis C 32.45 12.13 17 84181 328 29490001
Biliary colic 32.42 12.13 24 84174 869 29489460
Hepatic fibrosis 32.30 12.13 43 84155 3209 29487120
Alopecia universalis 32.29 12.13 11 84187 66 29490263
Gastrointestinal haemorrhage 32.25 12.13 117 84081 79416 29410913
Haemolysis 32.07 12.13 65 84133 6891 29483438
Drug reaction with eosinophilia and systemic symptoms 31.95 12.13 161 84037 27831 29462498
Pain in extremity 31.93 12.13 184 84014 110249 29380080
Myalgia 31.58 12.13 336 83862 73683 29416646
Hepatitis C RNA fluctuation 31.56 12.13 7 84191 3 29490326
Haematuria 31.50 12.13 48 84150 44091 29446238
Pneumocystis jirovecii pneumonia 31.50 12.13 5 84193 16774 29473555
Sarcoidosis 31.10 12.13 38 84160 2602 29487727
Pulmonary oedema 30.96 12.13 46 84152 42689 29447640
Affect lability 30.79 12.13 43 84155 3359 29486970
Constipation 30.49 12.13 195 84003 113965 29376364
Muscular weakness 30.27 12.13 84 84114 61968 29428361
Product prescribing error 30.26 12.13 7 84191 17969 29472360
Optic ischaemic neuropathy 29.94 12.13 32 84166 1894 29488435
Transfusion 29.92 12.13 65 84133 7233 29483096
Rhabdomyolysis 29.89 12.13 82 84116 60726 29429603
Clostridium difficile infection 29.87 12.13 5 84193 16136 29474193
Ocular icterus 29.78 12.13 37 84161 2578 29487751
Mood altered 29.63 12.13 69 84129 8042 29482287
Hepatitis C virus test 29.36 12.13 10 84188 60 29490269
Pyrexia 29.25 12.13 1046 83152 286576 29203753
Acute on chronic liver failure 28.96 12.13 11 84187 94 29490235
Product use issue 28.70 12.13 65 84133 51379 29438950
Injection site ulcer 28.42 12.13 14 84184 236 29490093
Psychotic disorder 28.31 12.13 124 84074 20230 29470099
Blood pressure decreased 28.28 12.13 54 84144 45423 29444906
Retinal detachment 28.10 12.13 49 84149 4637 29485692
Metabolic acidosis 27.81 12.13 40 84158 37622 29452707
Respiratory arrest 27.52 12.13 20 84178 25813 29464516
Musculoskeletal stiffness 27.45 12.13 40 84158 37418 29452911
International normalised ratio increased 27.32 12.13 53 84145 44319 29446010
Bilirubin conjugated increased 27.10 12.13 38 84160 2979 29487350
Arthropathy 26.69 12.13 14 84184 21540 29468789
Ammonia increased 26.62 12.13 44 84154 3987 29486342
Device related infection 26.50 12.13 6 84192 15630 29474699
Injection site reaction 26.47 12.13 81 84117 11107 29479222
Anorectal disorder 26.36 12.13 22 84176 951 29489378
Eczema 26.34 12.13 93 84105 13733 29476596
Hypocalcaemia 26.22 12.13 13 84185 20652 29469677
Chills 26.04 12.13 314 83884 70986 29419343
Therapeutic embolisation 25.88 12.13 14 84184 289 29490040
Renal disorder 25.81 12.13 130 84068 22465 29467864
Sleep apnoea syndrome 25.66 12.13 9 84189 17590 29472739
Sepsis 25.63 12.13 271 83927 142411 29347918
Acute myocardial infarction 25.58 12.13 63 84135 48375 29441954
Acute stress disorder 25.38 12.13 11 84187 136 29490193
Testicular germ cell tumour mixed 25.19 12.13 7 84191 18 29490311
Injection site pruritus 25.02 12.13 53 84145 5796 29484533
Acute myeloid leukaemia 24.85 12.13 8 84190 16505 29473824
Orthostatic hypotension 24.79 12.13 17 84181 22612 29467717
Haemophilic arthropathy 24.78 12.13 10 84188 102 29490227
Homicidal ideation 24.50 12.13 33 84165 2491 29487838
Blood cholesterol increased 24.48 12.13 7 84191 15588 29474741
Urinary retention 24.43 12.13 33 84165 31865 29458464
Heart rate irregular 24.42 12.13 4 84194 13113 29477216
Labelled drug-drug interaction medication error 24.29 12.13 3 84195 12156 29478173
Exposure via body fluid 23.87 12.13 10 84188 113 29490216
Depressed level of consciousness 23.74 12.13 43 84155 36899 29453430
Ejection fraction decreased 23.59 12.13 8 84190 15970 29474359
Thrombosis 23.51 12.13 55 84143 42990 29447339
Coma hepatic 23.43 12.13 15 84183 427 29489902
Genital herpes simplex 23.41 12.13 10 84188 119 29490210
Complications of transplanted liver 23.41 12.13 12 84186 221 29490108
Nasopharyngitis 23.38 12.13 89 84109 59576 29430753
Ventricular tachycardia 23.37 12.13 18 84180 22556 29467773
Herpes zoster 23.10 12.13 31 84167 30021 29460308
Type 1 diabetes mellitus 23.02 12.13 39 84159 3605 29486724
Alpha 1 foetoprotein increased 23.00 12.13 17 84181 614 29489715
Acute respiratory failure 22.66 12.13 25 84173 26377 29463952
Mobility decreased 22.58 12.13 24 84174 25756 29464573
Basal cell carcinoma 22.44 12.13 10 84188 16900 29473429
Seizure 22.41 12.13 164 84034 92959 29397370
Psoriatic arthropathy 22.32 12.13 7 84191 14684 29475645
Exposure via direct contact 22.30 12.13 7 84191 31 29490298
Neurotoxicity 22.13 12.13 7 84191 14606 29475723
Osteoarthritis 22.06 12.13 12 84186 18091 29472238
Pleural effusion 21.75 12.13 118 84080 71790 29418539
Toxic skin eruption 21.57 12.13 69 84129 9688 29480641
Emotional disorder 21.46 12.13 45 84153 4886 29485443
Somnolence 21.41 12.13 168 84030 93787 29396542
Ammonia abnormal 21.31 12.13 8 84190 66 29490263
Porphyria 21.29 12.13 7 84191 37 29490292
Upper respiratory tract infection 21.24 12.13 28 84170 27321 29463008
Diverticulitis 21.19 12.13 12 84186 17692 29472637
Urticaria 21.11 12.13 82 84116 54578 29435751
Synovitis 21.00 12.13 3 84195 10887 29479442
Respiratory distress 20.96 12.13 37 84161 32069 29458260
Hepatic neoplasm 20.94 12.13 26 84172 1810 29488519
Toxic epidermal necrolysis 20.75 12.13 13 84185 18140 29472189
Autoimmune hepatitis 20.74 12.13 37 84161 3565 29486764
Alanine aminotransferase increased 20.72 12.13 300 83898 70644 29419685
Injection site pain 20.64 12.13 38 84160 32408 29457921
Normal newborn 20.55 12.13 10 84188 164 29490165
Facial paresis 20.44 12.13 31 84167 2610 29487719
Asterixis 20.29 12.13 20 84178 1075 29489254
Premature baby 20.27 12.13 12 84186 17268 29473061
Memory impairment 20.22 12.13 175 84023 36295 29454034
Genital herpes 20.20 12.13 15 84183 546 29489783
Lethargy 20.14 12.13 179 84019 37401 29452928
Myelodysplastic syndrome 19.99 12.13 13 84185 17781 29472548
Product quality issue 19.98 12.13 94 84104 15801 29474528
Liver disorder 19.71 12.13 141 84057 27608 29462721
Tubulointerstitial nephritis 19.67 12.13 13 84185 17630 29472699
Anticoagulation drug level below therapeutic 19.63 12.13 16 84182 669 29489660
Hypervolaemia 19.46 12.13 13 84185 17532 29472797
Fat intolerance 19.46 12.13 4 84194 0 29490329
Pregnancy 19.39 12.13 11 84187 250 29490079
Squamous cell carcinoma 19.36 12.13 3 84195 10248 29480081
Palmar-plantar erythrodysaesthesia syndrome 19.16 12.13 9 84189 14750 29475579
Liver transplant failure 19.05 12.13 8 84190 91 29490238
Overdose 18.99 12.13 141 84057 79678 29410651
Sopor 18.93 12.13 4 84194 10930 29479399
Ischaemic stroke 18.88 12.13 11 84187 15966 29474363
Photophobia 18.71 12.13 48 84150 5947 29484382
Poisoning 18.71 12.13 3 84195 9990 29480339
Ventricular fibrillation 18.57 12.13 11 84187 15822 29474507
Sudden visual loss 18.54 12.13 5 84193 11 29490318
Chest discomfort 18.40 12.13 68 84130 45915 29444414
Angina pectoris 18.27 12.13 32 84166 27818 29462511
Mitochondrial toxicity 18.23 12.13 28 84170 2383 29487946
Diabetic hyperglycaemic coma 18.20 12.13 6 84192 32 29490297
Coma 18.07 12.13 55 84143 39395 29450934
Blood pressure systolic increased 18.00 12.13 13 84185 16832 29473497
Circulatory collapse 17.96 12.13 16 84182 18657 29471672
Sinusitis 17.88 12.13 45 84153 34305 29456024
Productive cough 17.83 12.13 39 84159 31220 29459109
Hip fracture 17.83 12.13 4 84194 10488 29479841
Oral lichen planus 17.74 12.13 9 84189 162 29490167
Gastric varices 17.73 12.13 12 84186 376 29489953
Alpha 1 foetoprotein abnormal 17.69 12.13 5 84193 14 29490315
Hepatic lesion 17.68 12.13 32 84166 3118 29487211
Feeling cold 17.66 12.13 62 84136 9129 29481200
Cholelithiasis 17.65 12.13 102 84096 18570 29471759
Anaphylactic shock 17.51 12.13 8 84190 13328 29477001
Blood iron increased 17.45 12.13 16 84182 785 29489544
Hyperlipidaemia 17.42 12.13 7 84191 12583 29477746
Photosensitivity reaction 17.40 12.13 62 84136 9196 29481133
Thirst 17.27 12.13 49 84149 6442 29483887
Bacterascites 17.23 12.13 4 84194 3 29490326
Neutropenic sepsis 17.09 12.13 6 84192 11721 29478608
Disease recurrence 17.09 12.13 90 84108 15824 29474505
Paraesthesia 17.04 12.13 87 84111 53758 29436571
Thought blocking 16.90 12.13 8 84190 123 29490206
Blood disorder 16.84 12.13 30 84168 2887 29487442
Portal hypertensive gastropathy 16.84 12.13 13 84185 502 29489827
Haematemesis 16.83 12.13 124 84074 24502 29465827
Intestinal obstruction 16.82 12.13 18 84180 19259 29471070
Parosmia 16.79 12.13 21 84177 1473 29488856
Drug interaction 16.71 12.13 431 83767 196954 29293375
Pityriasis 16.70 12.13 4 84194 4 29490325
Chronic kidney disease 16.51 12.13 51 84147 36365 29453964
Hepatitis E 16.42 12.13 22 84176 1652 29488677
Unresponsive to stimuli 16.36 12.13 29 84169 25097 29465232
Papilloedema 16.23 12.13 26 84172 2294 29488035
Feeling abnormal 16.20 12.13 231 83967 54214 29436115
Dyskinesia 16.14 12.13 20 84178 20041 29470288
Haemorrhoidal haemorrhage 16.03 12.13 30 84168 2999 29487330
Pneumonitis 15.99 12.13 35 84163 28009 29462320
Oral herpes 15.95 12.13 38 84160 4494 29485835
Mitral valve incompetence 15.92 12.13 9 84189 13284 29477045
Deafness congenital 15.84 12.13 7 84191 91 29490238
Emotional distress 15.81 12.13 10 84188 13885 29476444
Optic neuropathy 15.80 12.13 22 84176 1713 29488616
Cutaneous sarcoidosis 15.72 12.13 8 84190 145 29490184
Tachypnoea 15.71 12.13 12 84186 15103 29475226
Interstitial lung disease 15.70 12.13 98 84100 57620 29432709
Adrenal insufficiency 15.67 12.13 6 84192 11108 29479221
Injection site necrosis 15.62 12.13 11 84187 368 29489961
Hypomagnesaemia 15.59 12.13 16 84182 17452 29472877
Limb discomfort 15.57 12.13 4 84194 9564 29480765
Hydrocholecystis 15.55 12.13 10 84188 287 29490042
Nephritic syndrome 15.33 12.13 6 84192 56 29490273
Mouth ulceration 15.10 12.13 64 84134 10291 29480038
Bronchitis 15.09 12.13 54 84144 36814 29453515
Extrapyramidal disorder 15.02 12.13 6 84192 10825 29479504
Nasal congestion 15.00 12.13 19 84179 18860 29471469
Status epilepticus 14.93 12.13 6 84192 10788 29479541
Skin cancer 14.86 12.13 3 84195 8465 29481864
Hepatic amoebiasis 14.80 12.13 6 84192 62 29490267
Injection site dermatitis 14.77 12.13 4 84194 9 29490320
Body temperature decreased 14.64 12.13 6 84192 10658 29479671
Viral load undetectable 14.59 12.13 3 84195 0 29490329
Ear injury 14.54 12.13 5 84193 31 29490298
Therapy responder 14.50 12.13 8 84190 172 29490157
Aspergillus infection 14.45 12.13 6 84192 10575 29479754
Myopathy 14.34 12.13 6 84192 10527 29479802
Borderline personality disorder 14.32 12.13 10 84188 330 29489999
Loss of personal independence in daily activities 14.30 12.13 32 84166 25408 29464921
Nephrotic syndrome 14.21 12.13 45 84153 6283 29484046
Gait disturbance 14.11 12.13 137 84061 73212 29417117
Fungal infection 14.05 12.13 11 84187 13674 29476655
Infective spondylitis 14.05 12.13 8 84190 183 29490146
Dysphagia 14.05 12.13 95 84103 54831 29435498
Left ventricular dysfunction 13.96 12.13 4 84194 8898 29481431
Gene mutation identification test positive 13.95 12.13 7 84191 123 29490206
Procalcitonin 13.95 12.13 4 84194 12 29490317
Pulmonary tuberculosis 13.93 12.13 35 84163 4280 29486049
Bronchospasm 13.86 12.13 5 84193 9604 29480725
Osteonecrosis 13.72 12.13 11 84187 13508 29476821
Oedema due to hepatic disease 13.71 12.13 4 84194 13 29490316
Fundoscopy abnormal 13.71 12.13 4 84194 13 29490316
Lymphocyte count decreased 13.70 12.13 21 84177 19250 29471079
Sudden hearing loss 13.70 12.13 14 84184 786 29489543
COVID-19 pneumonia 13.66 12.13 5 84193 9517 29480812
Oesophageal variceal ligation 13.64 12.13 6 84192 77 29490252
Urinary tract infection 13.56 12.13 136 84062 72218 29418111
Retinal vein thrombosis 13.51 12.13 10 84188 362 29489967
Impaired work ability 13.50 12.13 41 84157 5599 29484730
Generalised tonic-clonic seizure 13.47 12.13 21 84177 19118 29471211
Delirium 13.42 12.13 62 84136 39335 29450994
Gallbladder cancer 13.31 12.13 8 84190 203 29490126
Inflammation 13.26 12.13 28 84170 22700 29467629
Atrial flutter 13.25 12.13 12 84186 13882 29476447
Hepatitis chronic active 13.24 12.13 5 84193 42 29490287
Skin irritation 13.18 12.13 35 84163 4426 29485903
Exposure during pregnancy 13.13 12.13 4 84194 8550 29481779
Hallucination, visual 13.13 12.13 14 84184 15001 29475328
Anxiety 13.12 12.13 327 83871 85038 29405291
Clostridium difficile colitis 13.09 12.13 11 84187 13201 29477128
Depressive symptom 13.07 12.13 20 84178 1697 29488632
Oesophagitis 13.00 12.13 9 84189 11914 29478415
Neutralising antibodies positive 12.99 12.13 6 84192 87 29490242
Mesenteric vein thrombosis 12.96 12.13 11 84187 487 29489842
Tongue ulceration 12.92 12.13 16 84182 1111 29489218
Ventricular extrasystoles 12.91 12.13 7 84191 10575 29479754
Infection 12.88 12.13 148 84050 76603 29413726
Drug level increased 12.86 12.13 21 84177 18766 29471563
Anti-erythropoietin antibody positive 12.86 12.13 14 84184 846 29489483
Hot flush 12.85 12.13 14 84184 14856 29475473
White blood cell count increased 12.81 12.13 59 84139 37457 29452872
Chromaturia 12.80 12.13 71 84127 12731 29477598
Hypokalaemia 12.76 12.13 87 84111 50116 29440213
Liver function test abnormal 12.76 12.13 41 84157 28877 29461452
Lung disorder 12.74 12.13 44 84154 30318 29460011
Granulocyte count decreased 12.70 12.13 12 84186 612 29489717
Hepatopulmonary syndrome 12.69 12.13 4 84194 18 29490311
Urinary incontinence 12.67 12.13 17 84181 16464 29473865
Pemphigoid 12.67 12.13 3 84195 7578 29482751
Aphasia 12.64 12.13 22 84176 19176 29471153
Bronchopulmonary aspergillosis 12.58 12.13 10 84188 12334 29477995
Vision blurred 12.57 12.13 172 84026 40004 29450325
Transaminases decreased 12.52 12.13 3 84195 3 29490326
Hypercatabolism 12.52 12.13 3 84195 3 29490326
Delusional disorder, erotomanic type 12.52 12.13 3 84195 3 29490326
Rales 12.49 12.13 3 84195 7507 29482822
Neoplasm malignant 12.47 12.13 18 84180 16907 29473422
Remission not achieved 12.46 12.13 6 84192 96 29490233
Post procedural haemorrhage 12.45 12.13 3 84195 7488 29482841
Alcoholism 12.43 12.13 25 84173 2636 29487693
Glossodynia 12.30 12.13 28 84170 3215 29487114
Aplasia pure red cell 12.29 12.13 39 84159 5452 29484877
Hypernatraemia 12.19 12.13 3 84195 7383 29482946
Respiratory tract infection 12.18 12.13 16 84182 15635 29474694
Rhinorrhoea 12.15 12.13 27 84171 21492 29468837

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Anaemia 5001.81 11.09 4686 114228 373994 64005824
Hepatocellular carcinoma 2345.88 11.09 793 118121 7610 64372208
Hepatitis C 2298.76 11.09 837 118077 10178 64369640
Haemoglobin decreased 1388.42 11.09 1751 117163 193312 64186506
White blood cell count decreased 1382.66 11.09 1575 117339 156262 64223556
Platelet count decreased 1051.43 11.09 1415 117499 166296 64213522
Hepatic cirrhosis 884.33 11.09 570 118344 25728 64354090
Rash 849.26 11.09 2293 116621 456256 63923562
Ascites 836.01 11.09 781 118133 61220 64318598
Neutrophil count decreased 774.34 11.09 828 118086 76368 64303450
Blood bilirubin increased 694.41 11.09 682 118232 56871 64322947
Hepatic encephalopathy 660.27 11.09 437 118477 20629 64359189
Fatigue 640.02 11.09 2896 116018 745834 63633984
Hyperbilirubinaemia 616.90 11.09 420 118494 20785 64359033
Jaundice 570.53 11.09 567 118347 47945 64331873
Insomnia 560.02 11.09 1169 117745 196667 64183151
Retinopathy 553.66 11.09 215 118699 3150 64376668
Influenza like illness 524.18 11.09 607 118307 61095 64318723
Hepatic failure 523.49 11.09 576 118338 54818 64325000
Depression 494.22 11.09 1062 117852 182229 64197589
Pruritus 485.76 11.09 1469 117445 310931 64068887
Hyperuricaemia 479.35 11.09 274 118640 9917 64369901
Decreased appetite 466.97 11.09 1354 117560 279935 64099883
Anal pruritus 442.41 11.09 123 118791 557 64379261
Genotype drug resistance test positive 402.85 11.09 126 118788 918 64378900
Leukopenia 401.16 11.09 691 118223 100551 64279267
Toxicity to various agents 389.04 11.09 96 118818 363417 64016401
Anorectal discomfort 369.73 11.09 154 118760 2731 64377087
Dysgeusia 363.40 11.09 441 118473 46606 64333212
Hepatic cancer 360.36 11.09 204 118710 7244 64372574
Oesophageal varices haemorrhage 338.90 11.09 155 118759 3474 64376344
Irritability 319.51 11.09 366 118548 36380 64343438
Viral load increased 316.17 11.09 132 118782 2355 64377463
Haemolytic anaemia 308.99 11.09 248 118666 15805 64364013
Infusion related reaction 286.75 11.09 3 118911 164464 64215354
Drug hypersensitivity 282.71 11.09 49 118865 237766 64142052
Pancytopenia 277.02 11.09 730 118184 142579 64237239
Completed suicide 265.08 11.09 47 118867 224367 64155451
Hepatitis C RNA positive 258.73 11.09 65 118849 179 64379639
Thrombocytopenia 256.93 11.09 951 117963 222850 64156968
Nausea 245.87 11.09 2364 116550 783436 63596382
Liver transplant 239.18 11.09 127 118787 3965 64375853
Proctalgia 222.82 11.09 151 118763 7408 64372410
Asthenia 218.22 11.09 1442 117472 426602 63953216
Fall 213.98 11.09 273 118641 416553 63963265
Virologic failure 212.32 11.09 111 118803 3355 64376463
Joint swelling 206.05 11.09 70 118844 215312 64164506
Hepatitis C RNA increased 200.29 11.09 59 118855 341 64379477
Dry skin 195.69 11.09 344 118570 50817 64329001
Cryoglobulinaemia 191.98 11.09 65 118849 625 64379193
Renal impairment 188.93 11.09 613 118301 134404 64245414
Rheumatoid arthritis 186.32 11.09 38 118876 164256 64215562
Varices oesophageal 181.78 11.09 115 118799 5015 64374803
Retinal exudates 176.93 11.09 70 118844 1080 64378738
Death 174.32 11.09 396 118518 482309 63897509
Treatment failure 172.19 11.09 540 118374 116276 64263542
Malignant neoplasm progression 171.00 11.09 9 118905 112862 64266956
Vogt-Koyanagi-Harada disease 169.61 11.09 45 118869 164 64379654
Hypotension 169.35 11.09 276 118638 380698 63999120
Contraindicated product administered 168.53 11.09 7 118907 107822 64271996
Peripheral swelling 167.96 11.09 88 118826 209065 64170753
Retinal haemorrhage 161.19 11.09 123 118791 7275 64372543
Synovitis 159.83 11.09 5 118909 99085 64280733
Red blood cell count decreased 159.35 11.09 305 118609 48081 64331737
Porphyria non-acute 158.57 11.09 57 118857 664 64379154
Drug abuse 157.81 11.09 27 118887 132347 64247471
Febrile neutropenia 156.62 11.09 75 118839 187582 64192236
Arthropathy 154.97 11.09 20 118894 120947 64258871
Peritonitis bacterial 153.72 11.09 130 118784 8913 64370905
Hypersensitivity 152.86 11.09 86 118828 196366 64183452
Hepatitis B reactivation 149.69 11.09 100 118814 4789 64375029
Hepatic cancer recurrent 149.50 11.09 42 118872 199 64379619
Off label use 144.18 11.09 639 118275 632167 63747651
Portal vein thrombosis 143.06 11.09 98 118816 4893 64374925
Drug eruption 142.11 11.09 246 118668 35890 64343928
Haemorrhoids 137.08 11.09 194 118720 23807 64356011
Erythema multiforme 135.78 11.09 156 118758 15545 64364273
Therapeutic product effect decreased 132.17 11.09 26 118888 115325 64264493
Oxygen saturation decreased 131.92 11.09 20 118894 107156 64272662
Condition aggravated 127.54 11.09 314 118600 372112 64007706
Product use in unapproved indication 125.37 11.09 86 118828 176532 64203286
Headache 124.77 11.09 1507 117407 527960 63851858
Viral mutation identified 123.56 11.09 77 118837 3269 64376549
Pain 122.33 11.09 565 118349 552946 63826872
Disease progression 120.70 11.09 55 118859 141625 64238193
Neutropenia 117.95 11.09 801 118113 238823 64140995
Hepatorenal syndrome 115.60 11.09 77 118837 3669 64376149
Drug intolerance 115.26 11.09 106 118808 187886 64191932
Therapeutic product effect incomplete 113.08 11.09 26 118888 103456 64276362
Product use issue 112.93 11.09 70 118844 151645 64228173
Blood uric acid increased 110.19 11.09 103 118811 8060 64371758
COVID-19 106.09 11.09 3 118911 65137 64314681
Cardiac failure congestive 103.22 11.09 56 118858 130524 64249294
Liver transplant rejection 103.20 11.09 66 118848 2933 64376885
Blood pressure increased 102.60 11.09 100 118814 172452 64207366
Hand deformity 101.82 11.09 3 118911 62768 64317050
Pyrexia 101.77 11.09 1518 117396 557126 63822692
Weight decreased 98.85 11.09 880 118034 284859 64094959
Weight increased 98.02 11.09 151 118763 213197 64166621
Nasopharyngitis 97.75 11.09 131 118783 195942 64183876
Autoimmune hepatitis 97.14 11.09 106 118808 9978 64369840
Wound 97.08 11.09 13 118901 76464 64303354
Musculoskeletal stiffness 94.27 11.09 55 118859 123151 64256667
Portal hypertension 92.78 11.09 83 118831 6136 64373682
Intentional overdose 91.74 11.09 26 118888 89918 64289900
Hepatic hydrothorax 91.49 11.09 22 118892 47 64379771
Flushing 87.45 11.09 19 118895 78629 64301189
Electrocardiogram QT prolonged 86.72 11.09 20 118894 79428 64300390
Mood swings 83.65 11.09 130 118784 17338 64362480
Cutaneous sarcoidosis 83.59 11.09 31 118883 397 64379421
Basedow's disease 82.94 11.09 27 118887 227 64379591
Sinusitis 81.72 11.09 89 118825 145839 64233979
Intentional product misuse 81.34 11.09 17 118897 72278 64307540
Injection site pain 79.35 11.09 54 118860 111354 64268464
Depressed mood 79.18 11.09 209 118705 40803 64339015
Pain in extremity 78.23 11.09 291 118623 302794 64077024
Anger 76.57 11.09 118 118796 15623 64364195
Maternal exposure during pregnancy 75.94 11.09 41 118873 95843 64283975
Hypertension 75.68 11.09 236 118678 259025 64120793
Blood pressure fluctuation 73.05 11.09 6 118908 51865 64327953
Systemic lupus erythematosus 72.81 11.09 26 118888 77586 64302232
Intentional product use issue 72.34 11.09 43 118871 95321 64284497
Yellow skin 70.78 11.09 53 118861 3046 64376772
Sarcoidosis 70.64 11.09 71 118843 6075 64373743
Glomerulonephritis membranoproliferative 70.36 11.09 29 118885 500 64379318
Child-Pugh-Turcotte score increased 68.63 11.09 16 118898 28 64379790
Vomiting 68.38 11.09 1409 117505 549708 63830110
Rash pruritic 67.41 11.09 246 118668 57158 64322660
Haemolysis 67.17 11.09 92 118822 10947 64368871
Swelling 65.63 11.09 122 118792 160096 64219722
Cardiac arrest 65.18 11.09 115 118799 153949 64225869
Osteoarthritis 65.15 11.09 18 118896 63318 64316500
Mobility decreased 64.69 11.09 39 118875 85801 64294017
Infection 63.86 11.09 155 118759 184725 64195093
Sedation 63.75 11.09 3 118911 41459 64338359
C-reactive protein increased 63.68 11.09 49 118865 94860 64284958
Hospitalisation 62.78 11.09 30 118884 75177 64304641
Anaphylactic reaction 62.73 11.09 24 118890 68640 64311178
Wheezing 61.59 11.09 36 118878 80543 64299275
Toxic skin eruption 61.56 11.09 120 118794 19164 64360654
Urticaria 61.39 11.09 111 118803 147206 64232612
Chills 61.10 11.09 448 118466 136816 64243002
Mucosal inflammation 60.37 11.09 20 118894 62564 64317254
Bilirubin conjugated increased 58.22 11.09 58 118856 4910 64374908
Blood cholesterol increased 57.93 11.09 11 118903 50055 64329763
Encephalopathy 57.59 11.09 238 118676 58581 64321237
Type 1 diabetes mellitus 56.75 11.09 61 118853 5644 64374174
Gastric varices haemorrhage 56.72 11.09 22 118892 321 64379497
Renal disorder 56.26 11.09 168 118746 35197 64344621
Arthralgia 56.12 11.09 533 118381 441727 63938091
Suicidal ideation 55.81 11.09 257 118657 66285 64313533
Plasma cell myeloma 55.77 11.09 9 118905 46066 64333752
Complications of transplanted liver 55.51 11.09 22 118892 341 64379477
Autoimmune thyroiditis 54.45 11.09 48 118866 3480 64376338
Hepatitis C virus test 54.29 11.09 15 118899 66 64379752
Serotonin syndrome 54.08 11.09 5 118909 39277 64340541
Hepatic enzyme increased 54.06 11.09 98 118816 129845 64249973
Coronary artery disease 53.76 11.09 22 118892 60411 64319407
Hyperthyroidism 53.09 11.09 109 118805 18070 64361748
Psychotic disorder 52.88 11.09 162 118752 34416 64345402
Disturbance in attention 52.49 11.09 181 118733 40893 64338925
Hepatic fibrosis 51.12 11.09 57 118857 5495 64374323
Pulmonary embolism 51.08 11.09 122 118792 146234 64233584
Hepatitis C virus test positive 50.17 11.09 20 118894 315 64379503
Depressive symptom 49.96 11.09 51 118863 4445 64375373
Facial paralysis 49.92 11.09 109 118805 18857 64360961
Optic ischaemic neuropathy 49.87 11.09 40 118874 2545 64377273
Therapy non-responder 49.81 11.09 247 118667 65652 64314166
Myalgia 49.45 11.09 478 118436 158139 64221679
Neuropathy peripheral 49.45 11.09 88 118826 117437 64262381
Blood pressure systolic increased 49.13 11.09 15 118899 49438 64330380
Psoriatic arthropathy 49.05 11.09 10 118904 43271 64336547
Injury 48.82 11.09 21 118893 55971 64323847
Alanine aminotransferase increased 48.39 11.09 429 118485 138602 64241216
Arthritis 48.15 11.09 50 118864 83764 64296054
Ocular icterus 48.08 11.09 53 118861 5045 64374773
Malaise 48.03 11.09 1010 117904 395237 63984581
Hepatitis C RNA 47.65 11.09 11 118903 18 64379800
Myocardial infarction 47.60 11.09 152 118762 165669 64214149
Rheumatoid factor positive 46.65 11.09 5 118909 34933 64344885
Nasal congestion 46.52 11.09 26 118888 59632 64320186
Alopecia universalis 46.00 11.09 16 118898 168 64379650
Gait disturbance 45.87 11.09 163 118751 171992 64207826
Dry mouth 45.34 11.09 226 118688 60192 64319626
Helicobacter infection 45.31 11.09 8 118906 38354 64341464
Eczema 45.22 11.09 139 118775 29581 64350237
Injection site rash 44.34 11.09 93 118821 15649 64364169
Hypoxia 43.78 11.09 59 118855 88090 64291728
Acute kidney injury 43.68 11.09 575 118339 448665 63931153
Duodenal ulcer perforation 43.66 11.09 6 118908 34619 64345199
Liver transplant failure 43.51 11.09 14 118900 113 64379705
Retinal detachment 43.38 11.09 63 118851 7913 64371905
Pneumonia aspiration 43.18 11.09 28 118886 59243 64320575
Heart rate decreased 42.94 11.09 24 118890 55043 64324775
Ammonia increased 42.22 11.09 58 118856 6919 64372899
Asthma 42.17 11.09 69 118845 95156 64284662
Cardio-respiratory arrest 42.00 11.09 73 118841 98320 64281498
Aplasia pure red cell 41.99 11.09 58 118856 6956 64372862
C-reactive protein abnormal 41.92 11.09 3 118911 29044 64350774
Loss of personal independence in daily activities 41.88 11.09 43 118871 72411 64307407
Cerebrovascular accident 41.70 11.09 123 118791 137460 64242358
Bradycardia 41.68 11.09 98 118816 118121 64261697
Tachycardia 41.62 11.09 139 118775 149440 64230378
Focal segmental glomerulosclerosis 41.38 11.09 38 118876 2906 64376912
Atrial fibrillation 41.06 11.09 169 118745 170920 64208898
Chronic hepatitis C 40.90 11.09 20 118894 523 64379295
Splenomegaly 40.38 11.09 97 118817 17864 64361954
Pneumonia 39.72 11.09 760 118154 558816 63821002
Clostridium difficile infection 39.66 11.09 9 118905 36154 64343664
Lower respiratory tract infection 39.66 11.09 71 118843 94543 64285275
Chest discomfort 39.55 11.09 98 118816 116008 64263810
Lethargy 39.48 11.09 249 118665 72345 64307473
Discomfort 39.29 11.09 55 118859 80823 64298995
Angiotensin converting enzyme increased 38.77 11.09 13 118901 121 64379697
Blood bilirubin unconjugated increased 38.73 11.09 23 118891 894 64378924
Somnolence 38.50 11.09 219 118695 203426 64176392
Knee arthroplasty 38.36 11.09 3 118911 26996 64352822
Product prescribing error 38.24 11.09 9 118905 35260 64344558
Hepatic neoplasm 38.06 11.09 37 118877 3040 64376778
Upper respiratory tract infection 37.92 11.09 47 118867 72738 64307080
Sopor 37.74 11.09 5 118909 29656 64350162
Pregnancy of partner 37.70 11.09 15 118899 235 64379583
Impaired healing 37.14 11.09 34 118880 60439 64319379
Hyperkalaemia 37.14 11.09 82 118832 101047 64278771
Transfusion 37.09 11.09 94 118820 17900 64361918
Alcoholism 36.59 11.09 38 118876 3379 64376439
Angioedema 36.51 11.09 36 118878 61785 64318033
Osteoporosis 36.34 11.09 16 118898 42064 64337754
Respiratory arrest 35.99 11.09 27 118887 52958 64326860
Pain in jaw 35.98 11.09 15 118899 40740 64339078
Skin disorder 35.38 11.09 122 118792 27558 64352260
Anorectal disorder 35.29 11.09 29 118885 1910 64377908
Basal cell carcinoma 35.20 11.09 7 118907 30831 64348987
Contusion 35.18 11.09 101 118813 113864 64265954
Overdose 35.01 11.09 163 118751 159403 64220415
Muscular weakness 34.97 11.09 119 118795 127219 64252599
Neuroleptic malignant syndrome 34.90 11.09 3 118911 24993 64354825
Device related infection 34.86 11.09 7 118907 30619 64349199
Muscle injury 34.75 11.09 4 118910 26433 64353385
Therapeutic embolisation 34.43 11.09 17 118897 454 64379364
Irritable bowel syndrome 34.23 11.09 13 118901 37356 64342462
Coma 33.88 11.09 69 118845 87546 64292272
Hypoglycaemia 33.74 11.09 72 118842 89820 64289998
Nephrotic syndrome 33.58 11.09 62 118852 9505 64370313
Sleep apnoea syndrome 33.58 11.09 7 118907 29825 64349993
Hyponatraemia 33.46 11.09 150 118764 148189 64231629
Hepatitis E 33.44 11.09 31 118883 2400 64377418
Emotional distress 32.25 11.09 13 118901 36025 64343793
Respiratory depression 32.23 11.09 3 118911 23440 64356378
Pneumocystis jirovecii pneumonia 32.12 11.09 6 118908 27628 64352190
Aspartate aminotransferase increased 32.08 11.09 350 118564 119438 64260380
Acute respiratory failure 31.96 11.09 27 118887 49907 64329911
Cardiogenic shock 31.91 11.09 10 118904 32417 64347401
Injection site ulcer 31.54 11.09 18 118896 649 64379169
Diverticulitis 31.33 11.09 16 118898 38602 64341216
Hip fracture 31.25 11.09 6 118908 27093 64352725
General physical health deterioration 30.97 11.09 235 118679 204190 64175628
Viral load 30.86 11.09 8 118906 26 64379792
Hypervolaemia 30.85 11.09 16 118898 38269 64341549
Wrong technique in product usage process 30.76 11.09 45 118869 64929 64314889
Drug reaction with eosinophilia and systemic symptoms 30.75 11.09 188 118726 54029 64325789
Exposure via body fluid 30.53 11.09 13 118901 244 64379574
Glossodynia 30.44 11.09 45 118869 64651 64315167
Paraesthesia 30.35 11.09 136 118778 134386 64245432
Respiratory failure 30.10 11.09 174 118740 161009 64218809
Hepatopulmonary syndrome 29.97 11.09 8 118906 30 64379788
Labelled drug-drug interaction medication error 29.86 11.09 3 118911 22059 64357759
Hepatitis C RNA fluctuation 29.36 11.09 6 118908 3 64379815
Herpes zoster 29.24 11.09 64 118850 79123 64300695
International normalised ratio increased 29.22 11.09 64 118850 79103 64300715
Bronchospasm 29.21 11.09 3 118911 21679 64358139
Testicular germ cell tumour mixed 29.10 11.09 7 118907 15 64379803
Surgery 29.05 11.09 8 118906 28205 64351613
Orthostatic hypotension 29.03 11.09 26 118888 46712 64333106
Throat irritation 28.94 11.09 12 118902 32699 64347119
Tongue pigmentation 28.81 11.09 8 118906 36 64379782
Glomerulonephritis 28.59 11.09 31 118883 2897 64376921
Chronic obstructive pulmonary disease 28.29 11.09 55 118859 70993 64308825
Palmar-plantar erythrodysaesthesia syndrome 28.16 11.09 9 118905 28810 64351008
Oedema due to hepatic disease 27.94 11.09 7 118907 19 64379799
Homicidal ideation 27.55 11.09 32 118882 3225 64376593
Limb discomfort 27.43 11.09 8 118906 27167 64352651
Mood altered 27.42 11.09 78 118836 15901 64363917
Dermatitis 27.13 11.09 84 118830 17945 64361873
Constipation 27.09 11.09 281 118633 229056 64150762
Anaphylactic shock 27.04 11.09 11 118903 30317 64349501
Gastric varices 26.95 11.09 15 118899 515 64379303
Injection site swelling 26.91 11.09 22 118892 41331 64338487
Unresponsive to stimuli 26.82 11.09 32 118882 50361 64329457
Ill-defined disorder 26.77 11.09 25 118889 44027 64335791
Portal hypertensive gastropathy 26.67 11.09 20 118894 1152 64378666
Affect lability 26.36 11.09 54 118860 8936 64370882
Pulmonary oedema 26.33 11.09 67 118847 78607 64301211
Hip arthroplasty 26.22 11.09 4 118910 21347 64358471
Device issue 26.15 11.09 5 118909 22643 64357175
Pericarditis 26.12 11.09 47 118867 62469 64317349
Rhinorrhoea 26.04 11.09 44 118870 59925 64319893
Liver disorder 25.97 11.09 178 118736 53173 64326645
Aplastic anaemia 25.91 11.09 70 118844 13850 64365968
Sudden hearing loss 25.86 11.09 23 118891 1687 64378131
Urate nephropathy 25.78 11.09 10 118904 146 64379672
Hepatic pain 25.64 11.09 32 118882 3476 64376342
Inflammation 25.61 11.09 51 118863 65249 64314569
Erythema nodosum 25.31 11.09 34 118880 3970 64375848
Disease recurrence 25.16 11.09 120 118794 31390 64348428
Acute stress disorder 24.95 11.09 13 118901 390 64379428
Photosensitivity reaction 24.91 11.09 82 118832 18091 64361727
Lymphocyte count decreased 24.85 11.09 23 118891 40676 64339142
Asterixis 24.81 11.09 26 118888 2337 64377481
Sudden visual loss 24.77 11.09 7 118907 34 64379784
Hypothyroidism 24.68 11.09 143 118771 40314 64339504
Exposure during pregnancy 24.59 11.09 68 118846 77607 64302211
Bronchitis 24.49 11.09 110 118804 108633 64271185
Pulmonary tuberculosis 24.25 11.09 46 118868 7198 64372620
Blood creatinine increased 24.18 11.09 368 118546 135414 64244404
Inappropriate schedule of product administration 24.15 11.09 88 118826 92198 64287620
Emotional disorder 24.07 11.09 64 118850 12543 64367275
Pancreatitis acute 23.92 11.09 148 118766 42707 64337111
Ocular sarcoidosis 23.76 11.09 6 118908 17 64379801
Folliculitis 23.60 11.09 13 118901 30064 64349754
Injection site dermatitis 23.50 11.09 6 118908 18 64379800
Oral lichen planus 23.46 11.09 15 118899 666 64379152
Immune thrombocytopenia 23.42 11.09 71 118843 14995 64364823
Anti-erythropoietin antibody positive 23.26 11.09 15 118899 676 64379142
Rash papular 23.26 11.09 77 118837 17036 64362782
Depressed level of consciousness 23.11 11.09 75 118839 81361 64298457
Abdominal discomfort 22.94 11.09 220 118694 182102 64197716
Biliary colic 22.94 11.09 30 118884 3414 64376404
Poisoning 22.91 11.09 6 118908 21873 64357945
Optic neuropathy 22.86 11.09 28 118886 2983 64376835
Acute on chronic liver failure 22.76 11.09 11 118903 280 64379538
Neurotoxicity 22.76 11.09 11 118903 27393 64352425
Urinary retention 22.39 11.09 35 118879 49166 64330652
Tendonitis 22.34 11.09 5 118909 20277 64359541
Thirst 22.33 11.09 67 118847 14070 64365748
Alpha 1 foetoprotein increased 22.33 11.09 15 118899 725 64379093
Thrombosis 22.24 11.09 62 118852 70580 64309238
Genital herpes simplex 22.07 11.09 11 118903 300 64379518
Mental disorder 22.06 11.09 102 118812 26343 64353475
Colitis 22.01 11.09 47 118867 58627 64321191
Intervertebral discitis 21.76 11.09 31 118883 3826 64375992
Chromaturia 21.74 11.09 91 118823 22520 64357298
Blood pressure diastolic decreased 21.73 11.09 7 118907 22294 64357524
Neutropenic sepsis 21.47 11.09 8 118906 23264 64356554
Acute myeloid leukaemia 21.36 11.09 12 118902 27451 64352367
Haemorrhoidal haemorrhage 21.26 11.09 38 118876 5681 64374137
Haematemesis 21.23 11.09 154 118760 46845 64332973
Hypersplenism 21.22 11.09 12 118902 425 64379393
Hepatitis virus-associated nephropathy 21.19 11.09 4 118910 0 64379818
Femur fracture 21.19 11.09 19 118895 34116 64345702
Injection site eczema 21.09 11.09 6 118908 30 64379788
Productive cough 21.06 11.09 67 118847 73136 64306682
Osteonecrosis 21.02 11.09 13 118901 28216 64351602
Musculoskeletal pain 20.96 11.09 78 118836 81216 64298602
Breast cancer 20.92 11.09 14 118900 29134 64350684
Fibromyalgia 20.88 11.09 21 118893 35710 64344108
Muscle spasticity 20.76 11.09 3 118911 16666 64363152
Body temperature decreased 20.65 11.09 11 118903 25917 64353901
Neutralising antibodies positive 20.61 11.09 10 118904 257 64379561
Fluid retention 20.53 11.09 50 118864 59556 64320262
Liver function test abnormal 20.33 11.09 50 118864 59351 64320467
Ejection fraction decreased 20.32 11.09 14 118900 28693 64351125
Thought blocking 20.21 11.09 9 118905 189 64379629
Anaemia macrocytic 20.04 11.09 32 118882 4366 64375452
Extradural abscess 19.99 11.09 17 118897 1174 64378644
Visual acuity reduced 19.98 11.09 101 118813 27040 64352778
Bleeding varicose vein 19.92 11.09 12 118902 479 64379339
Heart rate irregular 19.90 11.09 13 118901 27400 64352418
Blood disorder 19.88 11.09 41 118873 6816 64373002
Retinal vein occlusion 19.86 11.09 26 118888 2962 64376856
Torsade de pointes 19.70 11.09 4 118910 17359 64362459
Blood bilirubin abnormal 19.66 11.09 16 118898 1039 64378779
Blood albumin decreased 19.63 11.09 84 118830 20989 64358829
Blood pressure decreased 19.53 11.09 87 118827 86112 64293706
Myoclonus 19.50 11.09 11 118903 25107 64354711
Back pain 19.50 11.09 334 118580 249837 64129981
Toxic epidermal necrolysis 19.35 11.09 24 118890 37142 64342676
Status epilepticus 19.08 11.09 8 118906 21655 64358163
Granulocyte count decreased 18.98 11.09 17 118897 1259 64378559
Gastrointestinal disorder 18.87 11.09 93 118821 89616 64290202
Balance disorder 18.83 11.09 85 118829 83841 64295977
Myelodysplastic syndrome 18.80 11.09 14 118900 27565 64352253
Feeling cold 18.78 11.09 90 118824 23588 64356230
Hypocalcaemia 18.72 11.09 30 118884 41723 64338095
Limb injury 18.68 11.09 10 118904 23495 64356323
Anticoagulation drug level below therapeutic 18.57 11.09 17 118897 1295 64378523
Ammonia abnormal 18.46 11.09 8 118906 157 64379661
Lip swelling 18.36 11.09 19 118895 31888 64347930
Subarachnoid haemorrhage 18.35 11.09 75 118839 18363 64361455
Metabolic acidosis 18.35 11.09 68 118846 70890 64308928
Cardiac disorder 18.31 11.09 48 118866 55768 64324050
Paranoia 18.29 11.09 69 118845 16283 64363535
Dystonia 18.24 11.09 6 118908 18859 64360959
Throat tightness 18.19 11.09 10 118904 23150 64356668
Chronic hepatic failure 18.09 11.09 14 118900 845 64378973
Hydrocholecystis 18.00 11.09 10 118904 342 64379476
Haemophilic arthropathy 17.99 11.09 7 118907 103 64379715
Alpha 1 foetoprotein abnormal 17.97 11.09 6 118908 55 64379763
Product quality issue 17.96 11.09 105 118809 29694 64350124
Fungal infection 17.96 11.09 22 118892 34229 64345589
Neck pain 17.93 11.09 56 118858 61477 64318341
Remission not achieved 17.89 11.09 10 118904 346 64379472
Lung disorder 17.85 11.09 55 118859 60645 64319173
Eczema asteatotic 17.78 11.09 11 118903 461 64379357
Hypercalcaemia 17.75 11.09 19 118895 31397 64348421
Hepatitis cholestatic 17.70 11.09 56 118858 12099 64367719
Stress 17.70 11.09 55 118859 60479 64319339
Hypoalbuminaemia 17.67 11.09 72 118842 17602 64362216
Joint stiffness 17.61 11.09 18 118896 30386 64349432
Extrapyramidal disorder 17.58 11.09 7 118907 19545 64360273
Oral mucosal blistering 17.22 11.09 33 118881 5204 64374614
Pityriasis 17.16 11.09 4 118910 7 64379811
Clostridium difficile colitis 17.08 11.09 15 118899 27208 64352610
Peritoneal tuberculosis 17.07 11.09 11 118903 495 64379323
Dyskinesia 17.01 11.09 29 118885 39359 64340459
Incorrect route of product administration 16.97 11.09 11 118903 23287 64356531
Ventricular tachycardia 16.94 11.09 23 118891 34242 64345576
Cataract 16.88 11.09 44 118870 51218 64328600
Skin irritation 16.88 11.09 46 118868 9148 64370670
Lymph node tuberculosis 16.78 11.09 14 118900 942 64378876
Genital herpes 16.67 11.09 19 118895 1876 64377942
Pulmonary hypertension 16.65 11.09 34 118880 43105 64336713
Adverse drug reaction 16.57 11.09 37 118877 45427 64334391
COVID-19 pneumonia 16.40 11.09 5 118909 16499 64363319
Infective spondylitis 16.36 11.09 10 118904 410 64379408
Prostate cancer 16.36 11.09 8 118906 19787 64360031
Lower gastrointestinal haemorrhage 16.26 11.09 3 118911 13936 64365882
Bacterascites 16.20 11.09 4 118910 10 64379808
Gene mutation identification test positive 16.19 11.09 8 118906 214 64379604
Angina pectoris 16.18 11.09 37 118877 45044 64334774
Premature delivery 16.16 11.09 7 118907 18582 64361236
Muscle rigidity 16.13 11.09 6 118908 17467 64362351
Liver function test increased 16.12 11.09 20 118894 30950 64348868
Coma hepatic 16.08 11.09 14 118900 998 64378820
Face oedema 16.08 11.09 89 118825 24672 64355146
Gingival bleeding 16.05 11.09 62 118852 14792 64365026
Hepatic lesion 15.93 11.09 34 118880 5790 64374028
Model for end stage liver disease score 15.89 11.09 3 118911 0 64379818
Congenital uterine anomaly 15.89 11.09 3 118911 0 64379818
Vision blurred 15.77 11.09 244 118670 90072 64289746
Procalcitonin 15.67 11.09 4 118910 12 64379806
Seizure 15.66 11.09 215 118699 166677 64213141
Mitochondrial toxicity 15.63 11.09 22 118892 2684 64377134
Acute myocardial infarction 15.41 11.09 71 118843 69647 64310171
Decubitus ulcer 15.35 11.09 3 118911 13376 64366442
Hepatic amoebiasis 15.20 11.09 6 118908 92 64379726
Transaminases increased 15.19 11.09 137 118777 44457 64335361
Dyspnoea 15.11 11.09 1131 117783 717543 63662275
Hair disorder 15.09 11.09 13 118901 914 64378904
Tubulointerstitial nephritis 15.03 11.09 21 118893 30888 64348930
Overgrowth fungal 15.02 11.09 6 118908 95 64379723
Parosmia 14.96 11.09 29 118885 4611 64375207
Full blood count abnormal 14.91 11.09 100 118814 29657 64350161
Cheilitis 14.89 11.09 29 118885 4627 64375191
Procedural pain 14.88 11.09 5 118909 15503 64364315
Intentional self-injury 14.87 11.09 19 118895 29025 64350793
Unevaluable event 14.67 11.09 46 118868 50443 64329375
Injection site haemorrhage 14.49 11.09 14 118900 24264 64355554
Drug ineffective for unapproved indication 14.31 11.09 22 118892 31111 64348707
Lacrimation increased 14.29 11.09 8 118906 18338 64361480
Joint range of motion decreased 14.27 11.09 9 118905 19334 64360484
Incorrect product administration duration 14.25 11.09 45 118869 9713 64370105
Hot flush 14.24 11.09 41 118873 46194 64333624
Injection site mass 14.24 11.09 7 118907 17263 64362555
Complication associated with device 14.23 11.09 5 118909 15075 64364743
Serum ferritin increased 14.20 11.09 41 118873 8427 64371391
Heart rate increased 14.20 11.09 115 118799 98560 64281258
Immunodeficiency 14.13 11.09 6 118908 16118 64363700
Cardiac failure 14.10 11.09 166 118748 132207 64247611
Exposure via partner 14.06 11.09 4 118910 20 64379798
Hyperlipidaemia 14.01 11.09 13 118901 22963 64356855
General physical condition abnormal 13.85 11.09 31 118883 5451 64374367
Granulomatous liver disease 13.83 11.09 14 118900 1208 64378610
Cerebral arteriovenous malformation haemorrhagic 13.82 11.09 3 118911 3 64379815
Hashitoxicosis 13.82 11.09 3 118911 3 64379815
Tinnitus 13.82 11.09 109 118805 34024 64345794
Left ventricular dysfunction 13.79 11.09 7 118907 16947 64362871
Pancreas transplant rejection 13.78 11.09 8 118906 298 64379520
Oesophageal variceal ligation 13.70 11.09 6 118908 121 64379697
Ankle fracture 13.67 11.09 5 118909 14705 64365113
Intestinal obstruction 13.66 11.09 29 118885 36257 64343561
Syncope 13.65 11.09 384 118530 157251 64222567
VIIIth nerve lesion 13.60 11.09 4 118910 23 64379795
Injection site warmth 13.52 11.09 4 118910 13458 64366360
Bone disorder 13.51 11.09 7 118907 16752 64363066
Haemorrhoids thrombosed 13.50 11.09 7 118907 208 64379610
Red blood cell sedimentation rate increased 13.48 11.09 23 118891 31212 64348606
Therapy responder 13.45 11.09 9 118905 432 64379386
Disability 13.41 11.09 3 118911 12169 64367649
Chronic hepatitis 13.40 11.09 14 118900 1254 64378564
Chronic kidney disease 13.39 11.09 58 118856 57861 64321957
Hepatic mass 13.37 11.09 18 118896 2106 64377712
Rotator cuff syndrome 13.30 11.09 3 118911 12104 64367714
Deafness 13.29 11.09 68 118846 18291 64361527
Hypokinesia 13.28 11.09 7 118907 16589 64363229
Pneumonitis 13.19 11.09 48 118866 50317 64329501
Hypomagnesaemia 13.15 11.09 31 118883 37345 64342473
Sinus congestion 13.13 11.09 6 118908 15433 64364385
Aspergillus infection 12.97 11.09 7 118907 16372 64363446
Haematocrit decreased 12.96 11.09 156 118758 54499 64325319
Intestinal perforation 12.94 11.09 6 118908 15307 64364511
Injection site bruising 12.93 11.09 30 118884 36343 64343475
Pulmonary sarcoidosis 12.88 11.09 13 118901 1118 64378700
Mononeuropathy multiplex 12.85 11.09 8 118906 339 64379479
Joint injury 12.83 11.09 14 118900 22933 64356885
Rales 12.82 11.09 6 118908 15223 64364595
Pemphigoid 12.79 11.09 4 118910 12982 64366836
Portopulmonary hypertension 12.78 11.09 6 118908 143 64379675
Hypoaesthesia 12.76 11.09 180 118734 138928 64240890
Spinal fracture 12.74 11.09 6 118908 15168 64364650
Accidental exposure to product 12.73 11.09 18 118896 26346 64353472
Bipolar I disorder 12.69 11.09 16 118898 1755 64378063
Drug withdrawal syndrome 12.65 11.09 24 118890 31267 64348551
Exposure via direct contact 12.65 11.09 5 118909 77 64379741
Hepatocellular injury 12.60 11.09 42 118872 45193 64334625
Fat intolerance 12.57 11.09 4 118910 31 64379787
Xerosis 12.56 11.09 12 118902 965 64378853
Retinal disorder 12.52 11.09 16 118898 1780 64378038
Hepatorenal failure 12.49 11.09 13 118901 1159 64378659
Multiple sclerosis 12.42 11.09 10 118904 18931 64360887
Squamous cell carcinoma 12.41 11.09 5 118909 13864 64365954
Influenza 12.37 11.09 131 118783 106400 64273418
Portal vein flow decreased 12.35 11.09 4 118910 33 64379785
Upper limb fracture 12.30 11.09 6 118908 14860 64364958
Smooth muscle antibody positive 12.20 11.09 6 118908 159 64379659
Bursitis 12.13 11.09 13 118901 21472 64358346
Thyroiditis 12.11 11.09 23 118891 3601 64376217
Lichen planus 12.10 11.09 18 118896 2310 64377508
Prurigo 12.08 11.09 13 118901 1204 64378614
Deafness unilateral 12.03 11.09 23 118891 3619 64376199
Myopathy 12.02 11.09 9 118905 17671 64362147
Pulmonary mass 12.00 11.09 16 118898 24000 64355818
Febrile bone marrow aplasia 11.95 11.09 3 118911 11252 64368566
Hemiparesis 11.95 11.09 23 118891 29804 64350014
Acne 11.92 11.09 15 118899 23066 64356752
Live birth 11.87 11.09 3 118911 11201 64368617
Gallbladder cancer 11.86 11.09 8 118906 389 64379429
Acquired porphyria 11.86 11.09 4 118910 38 64379780
Disseminated intravascular coagulation 11.85 11.09 101 118813 32247 64347571
Granuloma annulare 11.84 11.09 9 118905 529 64379289
Posterior reversible encephalopathy syndrome 11.76 11.09 15 118899 22931 64356887
Oral tuberculosis 11.75 11.09 3 118911 9 64379809
Renal failure 11.66 11.09 427 118487 181261 64198557
Papilloedema 11.60 11.09 29 118885 5476 64374342
Haemochromatosis 11.59 11.09 13 118901 1261 64378557
Hyperalbuminaemia 11.59 11.09 4 118910 41 64379777
Antimitochondrial antibody positive 11.54 11.09 5 118909 98 64379720
Psoriasis 11.53 11.09 81 118833 71622 64308196
Miosis 11.52 11.09 5 118909 13261 64366557
Hepatectomy 11.52 11.09 6 118908 180 64379638
Choroiditis 11.48 11.09 12 118902 1075 64378743
Cytomegalovirus infection 11.45 11.09 33 118881 37166 64342652
Aphasia 11.38 11.09 38 118876 40868 64338950
Hyperhidrosis 11.33 11.09 162 118752 124758 64255060
Cholelithiasis 11.28 11.09 131 118783 45375 64334443
Cytomegalovirus viraemia 11.28 11.09 3 118911 10825 64368993
Gastrointestinal haemorrhage 11.17 11.09 174 118740 132138 64247680
Deep vein thrombosis 11.16 11.09 132 118782 105050 64274768
Lung abscess 11.15 11.09 22 118892 3544 64376274
Ischaemic stroke 11.11 11.09 23 118891 29012 64350806
Generalised tonic-clonic seizure 11.10 11.09 37 118877 39820 64339998

FDA Adverse Event Reporting System (Pediatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Exposure via body fluid 61.35 39.91 10 47 3 84618

Pharmacologic Action:

SourceCodeDescription
ATC J05AP01 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIVIRALS FOR SYSTEMIC USE
DIRECT ACTING ANTIVIRALS
Antivirals for treatment of HCV infections
FDA EXT N0000175459 Nucleoside Analog
FDA EPC N0000175466 Nucleoside Analog Antiviral
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000963 Antimetabolites
MeSH PA D000998 Antiviral Agents
MeSH PA D009676 Noxae
CHEBI has role CHEBI:22587 antiviral agents
CHEBI has role CHEBI:35221 antimetabolite
CHEBI has role CHEBI:35441 antiinfective agents
CHEBI has role CHEBI:59897 reverse transcriptase inhibitors
CHEBI has role CHEBI:149553 anticoronaviral drug

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Respiratory syncytial virus infection indication 55735004 DOID:1273
Chronic hepatitis C indication 128302006
Compensated cirrhosis indication 371139006
Lassa fever off-label use 19065005 DOID:9537
Influenza due to Influenza virus, type B off-label use 24662006
Congo-Crimean hemorrhagic fever off-label use 43489008 DOID:12287
Hemorrhagic nephroso-nephritis off-label use 102455002
Coronavirus infection off-label use 186747009
Rift valley fever off-label use 402917003 DOID:1328
Influenza due to Influenza A virus off-label use 442438000
Chronic obstructive lung disease contraindication 13645005 DOID:3083
Cirrhosis of liver contraindication 19943007 DOID:5082
Myocardial infarction contraindication 22298006 DOID:5844
Constitutional aplastic anemia contraindication 28975000 DOID:1342
Sarcoidosis contraindication 31541009 DOID:11335
Thalassemia contraindication 40108008 DOID:10241
Periodontitis contraindication 41565005 DOID:824
Coronary arteriosclerosis contraindication 53741008 DOID:3393
Hemolytic anemia contraindication 61261009 DOID:583
Interstitial pneumonia contraindication 64667001
Pancreatitis contraindication 75694006 DOID:4989
Pancytopenia contraindication 127034005 DOID:12450
Hb SS disease contraindication 127040003 DOID:10923
Asthma contraindication 195967001 DOID:2841
Impaired renal function disorder contraindication 197663003
Anemia contraindication 271737000 DOID:2355
Pregnancy, function contraindication 289908002
Bone marrow depression contraindication 307762000
Autoimmune hepatitis contraindication 408335007
Breastfeeding (mother) contraindication 413712001
Myocardial ischemia contraindication 414795007 DOID:3393
Pulmonary Infiltrates contraindication




๐Ÿถ Veterinary Drug Use

None

๐Ÿถ Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 11.65 acidic
pKa2 12.27 acidic
pKa3 13.44 acidic
pKa4 0.35 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Inosine-5'-monophosphate dehydrogenase 1 Enzyme INHIBITOR IC50 6 IUPHAR CHEMBL
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 Enzyme WOMBAT-PK
Cytosolic purine 5'-nucleotidase Enzyme WOMBAT-PK
Inosine-5'-monophosphate dehydrogenase 2 Enzyme INHIBITOR IC50 6 IUPHAR
DNA topoisomerase 1 Enzyme IC50 4.18 CHEMBL
Adenosine receptor A1 GPCR Ki 5.13 CHEMBL
Adenosine kinase Kinase WOMBAT-PK
NS5B protein Enzyme INHIBITOR CHEMBL CHEMBL
NS5 Unclassified EC50 4.68 CHEMBL
Adenosine receptor A1 GPCR Ki 5.35 CHEMBL

External reference:

IDSource
4019299 VUID
N0000147496 NUI
D00423 KEGG_DRUG
4019299 VANDF
C0035525 UMLSCUI
CHEBI:63580 CHEBI
RBV PDB_CHEM_ID
CHEMBL1643 ChEMBL_ID
DB00811 DRUGBANK_ID
D012254 MESH_DESCRIPTOR_UI
37542 PUBCHEM_CID
6842 IUPHAR_LIGAND_ID
3543 INN_ID
49717AWG6K UNII
9344 RXNORM
43465 MMSL
5421 MMSL
d00085 MMSL
003018 NDDF
35063004 SNOMEDCT_US
387188005 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
REBETOL HUMAN PRESCRIPTION DRUG LABEL 1 0085-1194 CAPSULE 200 mg ORAL NDA 31 sections
REBETOL HUMAN PRESCRIPTION DRUG LABEL 1 0085-1194 CAPSULE 200 mg ORAL NDA 31 sections
REBETOL HUMAN PRESCRIPTION DRUG LABEL 1 0085-1318 LIQUID 40 mg ORAL NDA 31 sections
REBETOL HUMAN PRESCRIPTION DRUG LABEL 1 0085-1318 LIQUID 40 mg ORAL NDA 31 sections
REBETOL HUMAN PRESCRIPTION DRUG LABEL 1 0085-1351 CAPSULE 200 mg ORAL NDA 31 sections
REBETOL HUMAN PRESCRIPTION DRUG LABEL 1 0085-1351 CAPSULE 200 mg ORAL NDA 31 sections
REBETOL HUMAN PRESCRIPTION DRUG LABEL 1 0085-1385 CAPSULE 200 mg ORAL NDA 31 sections
REBETOL HUMAN PRESCRIPTION DRUG LABEL 1 0085-1385 CAPSULE 200 mg ORAL NDA 31 sections
Virazole HUMAN PRESCRIPTION DRUG LABEL 1 0187-0007 POWDER, FOR SOLUTION 6 g RESPIRATORY (INHALATION) NDA 21 sections
Ribavirin HUMAN PRESCRIPTION DRUG LABEL 1 42494-423 POWDER, FOR SOLUTION 6 g RESPIRATORY (INHALATION) NDA 23 sections
Ribavirin HUMAN PRESCRIPTION DRUG LABEL 1 53808-0781 CAPSULE 200 mg ORAL ANDA 21 sections
Ribavirin HUMAN PRESCRIPTION DRUG LABEL 1 53808-0782 TABLET, FILM COATED 200 mg ORAL ANDA 16 sections
Ribavirin HUMAN PRESCRIPTION DRUG LABEL 1 63629-2149 POWDER, FOR SOLUTION 6 g RESPIRATORY (INHALATION) NDA 22 sections
Ribavirin HUMAN PRESCRIPTION DRUG LABEL 1 63629-2149 POWDER, FOR SOLUTION 6 g RESPIRATORY (INHALATION) NDA 22 sections
Ribavirin HUMAN PRESCRIPTION DRUG LABEL 1 65841-046 TABLET, FILM COATED 200 mg ORAL ANDA 1 sections
Ribavirin HUMAN PRESCRIPTION DRUG LABEL 1 65841-129 TABLET, FILM COATED 600 mg ORAL ANDA 1 sections
Ribavirin HUMAN PRESCRIPTION DRUG LABEL 1 65841-260 CAPSULE 200 mg ORAL ANDA 1 sections
Ribavirin HUMAN PRESCRIPTION DRUG LABEL 1 65841-603 TABLET, FILM COATED 400 mg ORAL ANDA 1 sections
Ribavirin HUMAN PRESCRIPTION DRUG LABEL 1 65841-632 TABLET, FILM COATED 500 mg ORAL ANDA 1 sections
Ribavirin Human Prescription Drug Label 1 65862-207 TABLET, FILM COATED 200 mg ORAL ANDA 28 sections
Ribavirin Human Prescription Drug Label 1 65862-207 TABLET, FILM COATED 200 mg ORAL ANDA 28 sections
Ribavirin Human Prescription Drug Label 1 65862-290 CAPSULE 200 mg ORAL ANDA 28 sections
Ribavirin Human Prescription Drug Label 1 65862-290 CAPSULE 200 mg ORAL ANDA 28 sections
Ribavirin HUMAN PRESCRIPTION DRUG LABEL 1 68382-046 TABLET, FILM COATED 200 mg ORAL ANDA 29 sections
Ribavirin HUMAN PRESCRIPTION DRUG LABEL 1 68382-127 TABLET, FILM COATED 400 mg ORAL ANDA 29 sections
Ribavirin HUMAN PRESCRIPTION DRUG LABEL 1 68382-128 TABLET, FILM COATED 500 mg ORAL ANDA 29 sections
Ribavirin HUMAN PRESCRIPTION DRUG LABEL 1 68382-129 TABLET, FILM COATED 600 mg ORAL ANDA 29 sections
Ribavirin HUMAN PRESCRIPTION DRUG LABEL 1 68382-260 CAPSULE 200 mg ORAL ANDA 28 sections
RIBAVIRIN HUMAN PRESCRIPTION DRUG LABEL 1 68382-395 POWDER, FOR SOLUTION 6 g RESPIRATORY (INHALATION) ANDA 19 sections
RIBAVIRIN HUMAN PRESCRIPTION DRUG LABEL 1 68475-003 POWDER, FOR SOLUTION 6 g RESPIRATORY (INHALATION) ANDA 19 sections