Stem definition | Drug id | CAS RN |
---|---|---|
antivirals | 2373 | 36791-04-5 |
Dose | Unit | Route |
---|---|---|
6 | g | Inhal.solution |
1 | g | O |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 142 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 17 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 35.10 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 60 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Vd (Volume of distribution) | 14 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 5.20 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 1 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 45 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
Dec. 31, 1985 | FDA | VALEANT PHARM INTL | |
Nov. 21, 2001 | PMDA | Schering-Plough |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Anaemia | 3410.27 | 13.14 | 2687 | 61055 | 249769 | 50291613 |
Haemoglobin decreased | 1000.58 | 13.14 | 1002 | 62740 | 126214 | 50415168 |
White blood cell count decreased | 902.26 | 13.14 | 911 | 62831 | 115811 | 50425571 |
Hepatitis C | 771.12 | 13.14 | 274 | 63468 | 4643 | 50536739 |
Platelet count decreased | 741.35 | 13.14 | 766 | 62976 | 99960 | 50441422 |
Hepatocellular carcinoma | 704.16 | 13.14 | 206 | 63536 | 1793 | 50539589 |
Neutrophil count decreased | 452.94 | 13.14 | 411 | 63331 | 45615 | 50495767 |
Decreased appetite | 349.83 | 13.14 | 777 | 62965 | 200146 | 50341236 |
Jaundice | 347.91 | 13.14 | 279 | 63463 | 26150 | 50515232 |
Blood bilirubin increased | 338.69 | 13.14 | 298 | 63444 | 31740 | 50509642 |
Rash | 334.62 | 13.14 | 1257 | 62485 | 436214 | 50105168 |
Ascites | 328.97 | 13.14 | 308 | 63434 | 35553 | 50505829 |
Hyperbilirubinaemia | 310.82 | 13.14 | 177 | 63565 | 9393 | 50531989 |
Anal pruritus | 301.86 | 13.14 | 81 | 63661 | 494 | 50540888 |
Hepatic cirrhosis | 300.74 | 13.14 | 217 | 63525 | 17360 | 50524022 |
Hepatic encephalopathy | 299.00 | 13.14 | 173 | 63569 | 9463 | 50531919 |
Dysgeusia | 298.45 | 13.14 | 303 | 63439 | 38613 | 50502769 |
Influenza like illness | 285.74 | 13.14 | 357 | 63385 | 57102 | 50484280 |
Depression | 263.57 | 13.14 | 618 | 63124 | 164805 | 50376577 |
Hepatic failure | 263.43 | 13.14 | 260 | 63482 | 32023 | 50509359 |
Anorectal discomfort | 260.65 | 13.14 | 99 | 63643 | 2038 | 50539344 |
Haemolytic anaemia | 257.31 | 13.14 | 155 | 63587 | 9137 | 50532245 |
Leukopenia | 249.40 | 13.14 | 363 | 63379 | 67165 | 50474217 |
Viral load increased | 245.54 | 13.14 | 81 | 63661 | 1082 | 50540300 |
Nausea | 243.36 | 13.14 | 1616 | 62126 | 703782 | 49837600 |
Fatigue | 241.07 | 13.14 | 1616 | 62126 | 705985 | 49835397 |
Asthenia | 236.85 | 13.14 | 909 | 62833 | 318133 | 50223249 |
Retinopathy | 217.76 | 13.14 | 93 | 63649 | 2619 | 50538763 |
Pruritus | 217.00 | 13.14 | 816 | 62926 | 282752 | 50258630 |
Insomnia | 202.85 | 13.14 | 580 | 63162 | 174285 | 50367097 |
Drug hypersensitivity | 202.57 | 13.14 | 36 | 63706 | 250974 | 50290408 |
Red blood cell count decreased | 202.32 | 13.14 | 231 | 63511 | 33604 | 50507778 |
Joint swelling | 181.72 | 13.14 | 43 | 63699 | 245243 | 50296139 |
Pancytopenia | 180.94 | 13.14 | 355 | 63387 | 83675 | 50457707 |
Thrombocytopenia | 166.32 | 13.14 | 442 | 63300 | 127231 | 50414151 |
Hyperuricaemia | 164.00 | 13.14 | 91 | 63651 | 4589 | 50536793 |
Contraindicated product administered | 161.23 | 13.14 | 6 | 63736 | 148952 | 50392430 |
Rheumatoid arthritis | 159.19 | 13.14 | 31 | 63711 | 202519 | 50338863 |
Toxicity to various agents | 152.04 | 13.14 | 40 | 63702 | 212459 | 50328923 |
Drug intolerance | 146.20 | 13.14 | 47 | 63695 | 219057 | 50322325 |
Vomiting | 144.00 | 13.14 | 1032 | 62710 | 459726 | 50081656 |
Therapeutic product effect decreased | 139.06 | 13.14 | 8 | 63734 | 136042 | 50405340 |
Completed suicide | 137.16 | 13.14 | 7 | 63735 | 131882 | 50409500 |
Hepatitis C RNA increased | 136.25 | 13.14 | 32 | 63710 | 101 | 50541281 |
Hepatitis C RNA positive | 135.46 | 13.14 | 28 | 63714 | 37 | 50541345 |
Arthropathy | 133.21 | 13.14 | 20 | 63722 | 157886 | 50383496 |
Product use issue | 133.07 | 13.14 | 16 | 63726 | 149459 | 50391923 |
Proctalgia | 127.10 | 13.14 | 79 | 63663 | 4924 | 50536458 |
Peripheral swelling | 124.17 | 13.14 | 52 | 63690 | 205884 | 50335498 |
Pyrexia | 120.59 | 13.14 | 855 | 62887 | 379348 | 50162034 |
Wound | 119.01 | 13.14 | 3 | 63739 | 105791 | 50435591 |
Systemic lupus erythematosus | 118.17 | 13.14 | 18 | 63724 | 140604 | 50400778 |
Off label use | 114.73 | 13.14 | 269 | 63473 | 474157 | 50067225 |
Hypersensitivity | 109.32 | 13.14 | 68 | 63674 | 215093 | 50326289 |
Cryoglobulinaemia | 106.45 | 13.14 | 34 | 63708 | 407 | 50540975 |
Dry skin | 105.94 | 13.14 | 193 | 63549 | 42998 | 50498384 |
Neutropenia | 102.40 | 13.14 | 413 | 63329 | 147552 | 50393830 |
Autoimmune hepatitis | 102.36 | 13.14 | 81 | 63661 | 7438 | 50533944 |
Chills | 101.70 | 13.14 | 310 | 63432 | 96377 | 50445005 |
Vogt-Koyanagi-Harada disease | 101.65 | 13.14 | 25 | 63717 | 101 | 50541281 |
Condition aggravated | 99.97 | 13.14 | 137 | 63605 | 296921 | 50244461 |
Weight decreased | 95.77 | 13.14 | 539 | 63203 | 220706 | 50320676 |
Pain | 88.65 | 13.14 | 402 | 63340 | 578501 | 49962881 |
Hyperthyroidism | 88.21 | 13.14 | 92 | 63650 | 12083 | 50529299 |
Irritability | 86.79 | 13.14 | 140 | 63602 | 28286 | 50513096 |
Oesophageal varices haemorrhage | 84.94 | 13.14 | 36 | 63706 | 994 | 50540388 |
Fall | 84.81 | 13.14 | 185 | 63557 | 334747 | 50206635 |
Hepatitis B reactivation | 82.62 | 13.14 | 44 | 63698 | 2043 | 50539339 |
Nasopharyngitis | 82.44 | 13.14 | 73 | 63669 | 192854 | 50348528 |
Hepatic cancer | 81.39 | 13.14 | 51 | 63691 | 3224 | 50538158 |
Genotype drug resistance test positive | 81.02 | 13.14 | 25 | 63717 | 265 | 50541117 |
Infection | 78.13 | 13.14 | 62 | 63680 | 172892 | 50368490 |
Portal vein thrombosis | 77.47 | 13.14 | 43 | 63699 | 2169 | 50539213 |
Retinal exudates | 77.20 | 13.14 | 30 | 63712 | 658 | 50540724 |
Porphyria non-acute | 76.25 | 13.14 | 24 | 63718 | 273 | 50541109 |
Death | 75.72 | 13.14 | 188 | 63554 | 325191 | 50216191 |
Swelling | 75.52 | 13.14 | 85 | 63657 | 200787 | 50340595 |
Cutaneous sarcoidosis | 74.27 | 13.14 | 24 | 63718 | 299 | 50541083 |
Malignant neoplasm progression | 72.80 | 13.14 | 3 | 63739 | 68121 | 50473261 |
Product use in unapproved indication | 71.78 | 13.14 | 28 | 63714 | 115791 | 50425591 |
Sinusitis | 69.94 | 13.14 | 67 | 63675 | 170491 | 50370891 |
Haemorrhoids | 68.19 | 13.14 | 101 | 63641 | 18952 | 50522430 |
Sarcoidosis | 68.19 | 13.14 | 54 | 63688 | 4963 | 50536419 |
Drug ineffective | 66.82 | 13.14 | 686 | 63056 | 818647 | 49722735 |
Hepatic enzyme increased | 66.23 | 13.14 | 46 | 63696 | 137334 | 50404048 |
Retinal haemorrhage | 65.92 | 13.14 | 51 | 63691 | 4530 | 50536852 |
Therapeutic product effect incomplete | 65.81 | 13.14 | 17 | 63725 | 91498 | 50449884 |
Blood uric acid increased | 64.79 | 13.14 | 47 | 63695 | 3787 | 50537595 |
Musculoskeletal stiffness | 64.66 | 13.14 | 41 | 63701 | 128440 | 50412942 |
Virologic failure | 61.99 | 13.14 | 33 | 63709 | 1531 | 50539851 |
Maternal exposure during pregnancy | 60.71 | 13.14 | 67 | 63675 | 159711 | 50381671 |
Abdominal discomfort | 58.52 | 13.14 | 128 | 63614 | 231513 | 50309869 |
Impaired healing | 58.44 | 13.14 | 9 | 63733 | 69777 | 50471605 |
Varices oesophageal | 58.40 | 13.14 | 39 | 63703 | 2750 | 50538632 |
Arthralgia | 58.20 | 13.14 | 320 | 63422 | 438382 | 50103000 |
Headache | 57.24 | 13.14 | 925 | 62817 | 505610 | 50035772 |
Renal impairment | 56.15 | 13.14 | 216 | 63526 | 75445 | 50465937 |
Erythema multiforme | 56.12 | 13.14 | 63 | 63679 | 8987 | 50532395 |
Oxygen saturation decreased | 55.84 | 13.14 | 12 | 63730 | 73236 | 50468146 |
Discomfort | 55.34 | 13.14 | 34 | 63708 | 108346 | 50433036 |
Disease progression | 54.90 | 13.14 | 26 | 63716 | 95840 | 50445542 |
Dehydration | 54.76 | 13.14 | 354 | 63388 | 152095 | 50389287 |
Osteoarthritis | 52.79 | 13.14 | 11 | 63731 | 68595 | 50472787 |
Pericarditis | 52.20 | 13.14 | 17 | 63725 | 78672 | 50462710 |
Transfusion | 51.43 | 13.14 | 72 | 63670 | 12833 | 50528549 |
Injection site pain | 51.12 | 13.14 | 39 | 63703 | 110985 | 50430397 |
Autoimmune thyroiditis | 50.41 | 13.14 | 38 | 63704 | 3247 | 50538135 |
Malaise | 50.27 | 13.14 | 644 | 63098 | 334888 | 50206494 |
Glossodynia | 50.22 | 13.14 | 43 | 63699 | 115526 | 50425856 |
Drug eruption | 49.85 | 13.14 | 99 | 63643 | 23507 | 50517875 |
Lower respiratory tract infection | 49.82 | 13.14 | 29 | 63713 | 95172 | 50446210 |
Blood cholesterol increased | 48.88 | 13.14 | 6 | 63736 | 55209 | 50486173 |
Mobility decreased | 48.43 | 13.14 | 20 | 63722 | 79928 | 50461454 |
Exposure via body fluid | 47.94 | 13.14 | 19 | 63723 | 440 | 50540942 |
Anger | 47.83 | 13.14 | 65 | 63677 | 11268 | 50530114 |
Rheumatoid factor positive | 47.82 | 13.14 | 4 | 63738 | 49855 | 50491527 |
Hypertension | 47.54 | 13.14 | 124 | 63618 | 211079 | 50330303 |
Intentional product use issue | 46.98 | 13.14 | 19 | 63723 | 76899 | 50464483 |
Intentional overdose | 46.12 | 13.14 | 11 | 63731 | 62493 | 50478889 |
Dry mouth | 45.53 | 13.14 | 165 | 63577 | 56013 | 50485369 |
Toxic skin eruption | 45.18 | 13.14 | 63 | 63679 | 11188 | 50530194 |
Drug reaction with eosinophilia and systemic symptoms | 44.90 | 13.14 | 106 | 63636 | 28318 | 50513064 |
Hepatic cancer recurrent | 44.58 | 13.14 | 10 | 63732 | 24 | 50541358 |
Basedow's disease | 44.16 | 13.14 | 16 | 63726 | 287 | 50541095 |
Pain in extremity | 43.07 | 13.14 | 187 | 63555 | 272678 | 50268704 |
Peritonitis bacterial | 42.63 | 13.14 | 40 | 63702 | 4621 | 50536761 |
Depressive symptom | 42.54 | 13.14 | 34 | 63708 | 3166 | 50538216 |
Exposure via father | 42.25 | 13.14 | 15 | 63727 | 253 | 50541129 |
Weight increased | 42.10 | 13.14 | 123 | 63619 | 201768 | 50339614 |
Liver transplant rejection | 41.91 | 13.14 | 24 | 63718 | 1286 | 50540096 |
Psoriatic arthropathy | 41.90 | 13.14 | 5 | 63737 | 47027 | 50494355 |
Hypothyroidism | 41.20 | 13.14 | 115 | 63627 | 34010 | 50507372 |
Febrile neutropenia | 40.44 | 13.14 | 38 | 63704 | 97629 | 50443753 |
Liver transplant | 40.33 | 13.14 | 28 | 63714 | 2104 | 50539278 |
Helicobacter infection | 40.29 | 13.14 | 7 | 63735 | 49695 | 50491687 |
Flushing | 40.21 | 13.14 | 17 | 63725 | 66998 | 50474384 |
Irritable bowel syndrome | 40.09 | 13.14 | 8 | 63734 | 51433 | 50489949 |
Rash pruritic | 40.02 | 13.14 | 142 | 63600 | 47704 | 50493678 |
Exposure via direct contact | 39.52 | 13.14 | 12 | 63730 | 120 | 50541262 |
Loss of personal independence in daily activities | 38.59 | 13.14 | 20 | 63722 | 70030 | 50471352 |
Child-Pugh-Turcotte score increased | 38.11 | 13.14 | 8 | 63734 | 12 | 50541370 |
Hepatorenal syndrome | 38.01 | 13.14 | 25 | 63717 | 1718 | 50539664 |
Drug abuse | 37.84 | 13.14 | 14 | 63728 | 59832 | 50481550 |
Tongue pigmentation | 36.66 | 13.14 | 8 | 63734 | 16 | 50541366 |
Urticaria | 35.74 | 13.14 | 68 | 63674 | 129493 | 50411889 |
Exposure via partner | 35.70 | 13.14 | 11 | 63731 | 116 | 50541266 |
Arthritis | 35.60 | 13.14 | 34 | 63708 | 86687 | 50454695 |
Hypotension | 35.56 | 13.14 | 164 | 63578 | 235305 | 50306077 |
Myalgia | 35.44 | 13.14 | 273 | 63469 | 124046 | 50417336 |
Hospitalisation | 35.10 | 13.14 | 21 | 63721 | 67916 | 50473466 |
Type 1 diabetes mellitus | 34.97 | 13.14 | 30 | 63712 | 3083 | 50538299 |
Bilirubin conjugated increased | 34.83 | 13.14 | 27 | 63715 | 2405 | 50538977 |
Yellow skin | 34.57 | 13.14 | 25 | 63717 | 2004 | 50539378 |
Hepatic fibrosis | 34.24 | 13.14 | 30 | 63712 | 3172 | 50538210 |
Blood pressure increased | 34.05 | 13.14 | 73 | 63669 | 133059 | 50408323 |
Blood pressure fluctuation | 34.00 | 13.14 | 3 | 63739 | 35820 | 50505562 |
C-reactive protein increased | 33.72 | 13.14 | 21 | 63721 | 66453 | 50474929 |
Injury | 33.46 | 13.14 | 10 | 63732 | 48915 | 50492467 |
Hepatitis C virus test positive | 33.39 | 13.14 | 10 | 63732 | 95 | 50541287 |
Thirst | 33.25 | 13.14 | 53 | 63689 | 10597 | 50530785 |
Intentional product misuse | 32.98 | 13.14 | 9 | 63733 | 46725 | 50494657 |
Angiotensin converting enzyme increased | 32.98 | 13.14 | 9 | 63733 | 59 | 50541323 |
Face oedema | 32.03 | 13.14 | 70 | 63672 | 17769 | 50523613 |
Electrocardiogram QT prolonged | 31.38 | 13.14 | 13 | 63729 | 51873 | 50489509 |
Aplastic anaemia | 30.73 | 13.14 | 43 | 63699 | 7660 | 50533722 |
Ammonia increased | 30.63 | 13.14 | 32 | 63710 | 4209 | 50537173 |
Nasal congestion | 30.61 | 13.14 | 13 | 63729 | 51107 | 50490275 |
Thyroiditis | 30.03 | 13.14 | 22 | 63720 | 1800 | 50539582 |
Encephalopathy | 29.88 | 13.14 | 102 | 63640 | 33609 | 50507773 |
Anorectal disorder | 29.42 | 13.14 | 20 | 63722 | 1452 | 50539930 |
Paternal drugs affecting foetus | 29.37 | 13.14 | 8 | 63734 | 52 | 50541330 |
Haemolysis | 29.26 | 13.14 | 37 | 63705 | 5979 | 50535403 |
Neuropathy peripheral | 29.19 | 13.14 | 48 | 63694 | 96709 | 50444673 |
Pregnancy of partner | 28.72 | 13.14 | 7 | 63735 | 27 | 50541355 |
Gastrointestinal disorder | 28.37 | 13.14 | 47 | 63695 | 94409 | 50446973 |
Wheezing | 28.29 | 13.14 | 22 | 63720 | 62025 | 50479357 |
Cardiac failure congestive | 28.22 | 13.14 | 39 | 63703 | 84343 | 50457039 |
Disturbance in attention | 28.20 | 13.14 | 95 | 63647 | 31091 | 50510291 |
Mood swings | 27.96 | 13.14 | 62 | 63680 | 15892 | 50525490 |
Viral mutation identified | 27.59 | 13.14 | 20 | 63722 | 1609 | 50539773 |
Osteoporosis | 27.54 | 13.14 | 11 | 63731 | 44868 | 50496514 |
Urate nephropathy | 27.43 | 13.14 | 9 | 63733 | 118 | 50541264 |
Complications of transplanted liver | 27.39 | 13.14 | 12 | 63730 | 360 | 50541022 |
Injection site rash | 27.38 | 13.14 | 62 | 63680 | 16115 | 50525267 |
Rash papular | 26.78 | 13.14 | 53 | 63689 | 12551 | 50528831 |
Gait disturbance | 26.67 | 13.14 | 98 | 63644 | 149907 | 50391475 |
Cardiac arrest | 26.66 | 13.14 | 40 | 63702 | 83611 | 50457771 |
Blood pressure systolic increased | 26.62 | 13.14 | 6 | 63736 | 35443 | 50505939 |
Ocular icterus | 26.51 | 13.14 | 27 | 63715 | 3448 | 50537934 |
Anaphylactic reaction | 26.16 | 13.14 | 18 | 63724 | 54037 | 50487345 |
Glomerulonephritis | 26.09 | 13.14 | 19 | 63723 | 1540 | 50539842 |
Pulmonary embolism | 25.81 | 13.14 | 56 | 63686 | 101648 | 50439734 |
Hypersplenism | 25.58 | 13.14 | 10 | 63732 | 223 | 50541159 |
Disease recurrence | 25.55 | 13.14 | 69 | 63673 | 20012 | 50521370 |
Alcoholism | 25.44 | 13.14 | 19 | 63723 | 1601 | 50539781 |
Therapy non-responder | 25.18 | 13.14 | 129 | 63613 | 50893 | 50490489 |
Liver transplant failure | 24.86 | 13.14 | 6 | 63736 | 22 | 50541360 |
Splenomegaly | 24.73 | 13.14 | 44 | 63698 | 9616 | 50531766 |
Glomerulonephritis membranoproliferative | 24.66 | 13.14 | 9 | 63733 | 165 | 50541217 |
Full blood count abnormal | 24.56 | 13.14 | 75 | 63667 | 23313 | 50518069 |
Coronary artery disease | 24.51 | 13.14 | 4 | 63738 | 29722 | 50511660 |
Hepatitis C virus test | 24.46 | 13.14 | 5 | 63737 | 6 | 50541376 |
Aplasia pure red cell | 23.87 | 13.14 | 28 | 63714 | 4187 | 50537195 |
Subarachnoid haemorrhage | 23.73 | 13.14 | 46 | 63696 | 10730 | 50530652 |
Memory impairment | 23.01 | 13.14 | 175 | 63567 | 79185 | 50462197 |
Pancreas transplant rejection | 22.81 | 13.14 | 8 | 63734 | 130 | 50541252 |
Erythema nodosum | 22.22 | 13.14 | 26 | 63716 | 3877 | 50537505 |
Crying | 21.94 | 13.14 | 66 | 63676 | 20350 | 50521032 |
Alanine aminotransferase increased | 21.90 | 13.14 | 188 | 63554 | 88171 | 50453211 |
Feeling cold | 21.80 | 13.14 | 64 | 63678 | 19467 | 50521915 |
Ill-defined disorder | 21.76 | 13.14 | 22 | 63720 | 54632 | 50486750 |
Hepatic hydrothorax | 21.73 | 13.14 | 5 | 63737 | 14 | 50541368 |
Deep vein thrombosis | 21.52 | 13.14 | 37 | 63705 | 73267 | 50468115 |
Inflammation | 21.44 | 13.14 | 24 | 63718 | 56888 | 50484494 |
Extradural abscess | 21.19 | 13.14 | 13 | 63729 | 791 | 50540591 |
Adverse drug reaction | 21.12 | 13.14 | 23 | 63719 | 55199 | 50486183 |
Pain in jaw | 21.12 | 13.14 | 11 | 63731 | 38417 | 50502965 |
Serotonin syndrome | 21.12 | 13.14 | 3 | 63739 | 24710 | 50516672 |
Surgery | 20.97 | 13.14 | 6 | 63736 | 30199 | 50511183 |
Chronic kidney disease | 20.96 | 13.14 | 12 | 63730 | 39759 | 50501623 |
Oral mucosal blistering | 20.91 | 13.14 | 28 | 63714 | 4784 | 50536598 |
Skin disorder | 20.68 | 13.14 | 72 | 63670 | 23958 | 50517424 |
Hepatitis E | 20.62 | 13.14 | 15 | 63727 | 1214 | 50540168 |
Haematocrit decreased | 20.56 | 13.14 | 93 | 63649 | 34883 | 50506499 |
Maternal exposure before pregnancy | 20.50 | 13.14 | 30 | 63712 | 5567 | 50535815 |
Chest discomfort | 20.40 | 13.14 | 55 | 63687 | 92667 | 50448715 |
Plasma cell myeloma | 20.36 | 13.14 | 7 | 63735 | 31315 | 50510067 |
Sleep apnoea syndrome | 20.16 | 13.14 | 3 | 63739 | 23865 | 50517517 |
Hypervolaemia | 19.79 | 13.14 | 4 | 63738 | 25495 | 50515887 |
Muscular weakness | 19.70 | 13.14 | 58 | 63684 | 94955 | 50446427 |
Emotional disorder | 19.63 | 13.14 | 45 | 63697 | 11791 | 50529591 |
Renal failure | 19.58 | 13.14 | 213 | 63529 | 106420 | 50434962 |
Suicidal ideation | 19.48 | 13.14 | 128 | 63614 | 55257 | 50486125 |
Viral load decreased | 19.30 | 13.14 | 5 | 63737 | 26 | 50541356 |
Intentional self-injury | 19.30 | 13.14 | 3 | 63739 | 23109 | 50518273 |
Hepatorenal failure | 19.16 | 13.14 | 11 | 63731 | 592 | 50540790 |
Hepatopulmonary syndrome | 19.06 | 13.14 | 4 | 63738 | 6 | 50541376 |
Blood disorder | 19.04 | 13.14 | 29 | 63713 | 5576 | 50535806 |
Contusion | 18.83 | 13.14 | 75 | 63667 | 112108 | 50429274 |
Injection site swelling | 18.80 | 13.14 | 15 | 63727 | 41758 | 50499624 |
Constipation | 18.69 | 13.14 | 147 | 63595 | 185561 | 50355821 |
Type 2 diabetes mellitus | 18.65 | 13.14 | 10 | 63732 | 34365 | 50507017 |
Chromaturia | 18.43 | 13.14 | 50 | 63692 | 14540 | 50526842 |
Aspartate aminotransferase increased | 18.31 | 13.14 | 164 | 63578 | 77834 | 50463548 |
Dermatitis | 18.16 | 13.14 | 49 | 63693 | 14202 | 50527180 |
Mental disorder | 18.15 | 13.14 | 65 | 63677 | 21926 | 50519456 |
Retinal detachment | 18.08 | 13.14 | 27 | 63715 | 5102 | 50536280 |
Liver function test increased | 17.94 | 13.14 | 5 | 63737 | 25601 | 50515781 |
Alopecia | 17.82 | 13.14 | 419 | 63323 | 244628 | 50296754 |
Overgrowth fungal | 17.55 | 13.14 | 6 | 63736 | 90 | 50541292 |
Anti-erythropoietin antibody positive | 17.51 | 13.14 | 9 | 63733 | 388 | 50540994 |
Hypophagia | 17.26 | 13.14 | 75 | 63667 | 27653 | 50513729 |
Hepatitis cholestatic | 17.15 | 13.14 | 29 | 63713 | 6088 | 50535294 |
Rhinorrhoea | 17.09 | 13.14 | 24 | 63718 | 51559 | 50489823 |
Hepatitis virus-associated nephropathy | 17.04 | 13.14 | 3 | 63739 | 0 | 50541382 |
Miscarriage of partner | 17.04 | 13.14 | 3 | 63739 | 0 | 50541382 |
Ocular sarcoidosis | 17.04 | 13.14 | 5 | 63737 | 44 | 50541338 |
Hashitoxicosis | 17.04 | 13.14 | 3 | 63739 | 0 | 50541382 |
Hepatitis C RNA decreased | 17.04 | 13.14 | 3 | 63739 | 0 | 50541382 |
Lymphocyte count decreased | 16.89 | 13.14 | 6 | 63736 | 26301 | 50515081 |
Product prescribing error | 16.88 | 13.14 | 3 | 63739 | 20958 | 50520424 |
Pneumonia aspiration | 16.85 | 13.14 | 9 | 63733 | 30995 | 50510387 |
Gastric varices haemorrhage | 16.75 | 13.14 | 6 | 63736 | 104 | 50541278 |
Cerebrovascular accident | 16.73 | 13.14 | 62 | 63680 | 94618 | 50446764 |
Facial paralysis | 16.49 | 13.14 | 44 | 63698 | 12671 | 50528711 |
Blood bilirubin unconjugated increased | 16.38 | 13.14 | 8 | 63734 | 309 | 50541073 |
Hepatitis B | 16.35 | 13.14 | 21 | 63721 | 3445 | 50537937 |
Epistaxis | 16.33 | 13.14 | 137 | 63605 | 63817 | 50477565 |
Herpes zoster | 16.33 | 13.14 | 41 | 63701 | 70745 | 50470637 |
Guillain-Barre syndrome | 16.30 | 13.14 | 21 | 63721 | 3456 | 50537926 |
Rhinocerebral mucormycosis | 16.29 | 13.14 | 7 | 63735 | 200 | 50541182 |
Paraesthesia | 16.26 | 13.14 | 87 | 63655 | 120156 | 50421226 |
Eczema | 16.17 | 13.14 | 64 | 63678 | 22638 | 50518744 |
Bursitis | 16.12 | 13.14 | 4 | 63738 | 22131 | 50519251 |
Retinal disorder | 16.12 | 13.14 | 14 | 63728 | 1463 | 50539919 |
Emotional distress | 16.05 | 13.14 | 8 | 63734 | 28655 | 50512727 |
Bronchitis | 16.02 | 13.14 | 72 | 63670 | 104087 | 50437295 |
Abortion induced | 16.02 | 13.14 | 36 | 63706 | 9308 | 50532074 |
Clostridium difficile infection | 16.00 | 13.14 | 6 | 63736 | 25433 | 50515949 |
Anaphylactic shock | 15.98 | 13.14 | 3 | 63739 | 20152 | 50521230 |
Respiratory arrest | 15.89 | 13.14 | 9 | 63733 | 30000 | 50511382 |
Hemiparesis | 15.87 | 13.14 | 3 | 63739 | 20045 | 50521337 |
Device issue | 15.78 | 13.14 | 3 | 63739 | 19969 | 50521413 |
VIIIth nerve lesion | 15.57 | 13.14 | 4 | 63738 | 20 | 50541362 |
Gingival bleeding | 15.45 | 13.14 | 40 | 63702 | 11313 | 50530069 |
Depressed mood | 15.40 | 13.14 | 84 | 63658 | 33939 | 50507443 |
Bleeding varicose vein | 15.38 | 13.14 | 7 | 63735 | 230 | 50541152 |
Upper respiratory tract infection | 15.33 | 13.14 | 38 | 63704 | 65860 | 50475522 |
Portal hypertension | 15.15 | 13.14 | 20 | 63722 | 3372 | 50538010 |
Psoriasis | 15.12 | 13.14 | 41 | 63701 | 68959 | 50472423 |
Mucosal inflammation | 15.04 | 13.14 | 17 | 63725 | 40125 | 50501257 |
Cerebral arteriovenous malformation haemorrhagic | 14.96 | 13.14 | 3 | 63739 | 3 | 50541379 |
Limb discomfort | 14.89 | 13.14 | 6 | 63736 | 24351 | 50517031 |
Oral candidiasis | 14.83 | 13.14 | 51 | 63691 | 16864 | 50524518 |
Hypoxia | 14.83 | 13.14 | 26 | 63716 | 51097 | 50490285 |
Blood bilirubin abnormal | 14.71 | 13.14 | 10 | 63732 | 726 | 50540656 |
Paranoia | 14.64 | 13.14 | 37 | 63705 | 10311 | 50531071 |
Immune thrombocytopenia | 14.64 | 13.14 | 34 | 63708 | 8983 | 50532399 |
Blood potassium decreased | 14.62 | 13.14 | 88 | 63654 | 36857 | 50504525 |
Congenital tongue anomaly | 14.50 | 13.14 | 3 | 63739 | 4 | 50541378 |
Disseminated intravascular coagulation | 14.45 | 13.14 | 51 | 63691 | 17084 | 50524298 |
Injection site eczema | 14.43 | 13.14 | 4 | 63738 | 28 | 50541354 |
Alopecia universalis | 14.33 | 13.14 | 5 | 63737 | 80 | 50541302 |
Joint range of motion decreased | 14.17 | 13.14 | 3 | 63739 | 18509 | 50522873 |
Hepatic neoplasm | 14.14 | 13.14 | 14 | 63728 | 1728 | 50539654 |
Myocardial infarction | 14.02 | 13.14 | 61 | 63681 | 88966 | 50452416 |
Femur fracture | 13.89 | 13.14 | 16 | 63726 | 37448 | 50503934 |
Fibromyalgia | 13.85 | 13.14 | 22 | 63720 | 44956 | 50496426 |
Syncope | 13.82 | 13.14 | 194 | 63548 | 102808 | 50438574 |
Liver injury | 13.78 | 13.14 | 7 | 63735 | 24799 | 50516583 |
Oedema due to hepatic disease | 13.75 | 13.14 | 3 | 63739 | 6 | 50541376 |
Bronchopulmonary disease | 13.75 | 13.14 | 3 | 63739 | 6 | 50541376 |
Psychotic disorder | 13.58 | 13.14 | 59 | 63683 | 21753 | 50519629 |
Joint stiffness | 13.49 | 13.14 | 11 | 63731 | 30297 | 50511085 |
Blood albumin decreased | 13.48 | 13.14 | 42 | 63700 | 13194 | 50528188 |
Throat irritation | 13.43 | 13.14 | 11 | 63731 | 30228 | 50511154 |
Portal hypertensive gastropathy | 13.27 | 13.14 | 9 | 63733 | 651 | 50540731 |
Chronic hepatic failure | 13.25 | 13.14 | 8 | 63734 | 473 | 50540909 |
Cholangitis | 13.22 | 13.14 | 22 | 63720 | 4557 | 50536825 |
Lethargy | 13.21 | 13.14 | 107 | 63635 | 49325 | 50492057 |
Breast cancer | 13.19 | 13.14 | 21 | 63721 | 42869 | 50498513 |
Hypoglycaemia | 13.18 | 13.14 | 30 | 63712 | 53551 | 50487831 |
Non-neutralising antibodies positive | 13.15 | 13.14 | 3 | 63739 | 8 | 50541374 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Anaemia | 2466.63 | 12.13 | 2933 | 81265 | 198018 | 29292311 |
Hepatitis C | 1771.07 | 12.13 | 736 | 83462 | 8174 | 29482155 |
Hepatocellular carcinoma | 1760.52 | 12.13 | 686 | 83512 | 6352 | 29483977 |
Rash | 987.34 | 12.13 | 1858 | 82340 | 187961 | 29302368 |
White blood cell count decreased | 720.03 | 12.13 | 1028 | 83170 | 82334 | 29407995 |
Hepatic cirrhosis | 705.05 | 12.13 | 465 | 83733 | 13979 | 29476350 |
Fatigue | 698.38 | 12.13 | 2227 | 81971 | 314594 | 29175735 |
Haemoglobin decreased | 633.82 | 12.13 | 1118 | 83080 | 107257 | 29383072 |
Influenza like illness | 560.18 | 12.13 | 502 | 83696 | 23968 | 29466361 |
Pruritus | 538.51 | 12.13 | 1089 | 83109 | 115760 | 29374569 |
Treatment failure | 518.57 | 12.13 | 581 | 83617 | 36358 | 29453971 |
Ascites | 514.13 | 12.13 | 576 | 83622 | 36043 | 29454286 |
Insomnia | 448.17 | 12.13 | 860 | 83338 | 87901 | 29402428 |
Platelet count decreased | 423.10 | 12.13 | 925 | 83273 | 103747 | 29386582 |
Hepatic encephalopathy | 420.01 | 12.13 | 326 | 83872 | 12709 | 29477620 |
Genotype drug resistance test positive | 401.32 | 12.13 | 139 | 84059 | 884 | 29489445 |
Blood bilirubin increased | 395.51 | 12.13 | 485 | 83713 | 33408 | 29456921 |
Depression | 386.32 | 12.13 | 789 | 83409 | 84358 | 29405971 |
Anorectal discomfort | 377.12 | 12.13 | 150 | 84048 | 1469 | 29488860 |
Retinopathy | 348.67 | 12.13 | 146 | 84052 | 1649 | 29488680 |
Anal pruritus | 337.59 | 12.13 | 93 | 84105 | 229 | 29490100 |
Dysgeusia | 322.06 | 12.13 | 359 | 83839 | 22315 | 29468014 |
Hepatic failure | 304.86 | 12.13 | 411 | 83787 | 31101 | 29459228 |
Irritability | 294.65 | 12.13 | 339 | 83859 | 21813 | 29468516 |
Death | 290.35 | 12.13 | 329 | 83869 | 341755 | 29148574 |
Toxicity to various agents | 286.69 | 12.13 | 71 | 84127 | 173590 | 29316739 |
Neutrophil count decreased | 286.23 | 12.13 | 474 | 83724 | 43093 | 29447236 |
Hyperbilirubinaemia | 275.64 | 12.13 | 272 | 83926 | 14662 | 29475667 |
Hepatic cancer | 274.69 | 12.13 | 191 | 84007 | 6265 | 29484064 |
Liver transplant | 261.29 | 12.13 | 129 | 84069 | 2187 | 29488142 |
Hyperuricaemia | 261.25 | 12.13 | 190 | 84008 | 6699 | 29483630 |
Jaundice | 248.86 | 12.13 | 359 | 83839 | 28937 | 29461392 |
Oesophageal varices haemorrhage | 236.88 | 12.13 | 127 | 84071 | 2575 | 29487754 |
Viral load increased | 236.74 | 12.13 | 116 | 84082 | 1933 | 29488396 |
Headache | 232.96 | 12.13 | 1046 | 83152 | 172961 | 29317368 |
Decreased appetite | 212.20 | 12.13 | 897 | 83301 | 144445 | 29345884 |
Nausea | 195.63 | 12.13 | 1449 | 82749 | 287806 | 29202523 |
Febrile neutropenia | 184.83 | 12.13 | 46 | 84152 | 112194 | 29378135 |
Virologic failure | 179.84 | 12.13 | 108 | 84090 | 2739 | 29487590 |
Malignant neoplasm progression | 179.70 | 12.13 | 7 | 84191 | 73852 | 29416477 |
Leukopenia | 178.95 | 12.13 | 448 | 83750 | 54755 | 29435574 |
Hypotension | 176.57 | 12.13 | 176 | 84022 | 194178 | 29296151 |
Hepatitis C RNA positive | 154.68 | 12.13 | 44 | 84154 | 127 | 29490202 |
Hepatitis C RNA increased | 152.94 | 12.13 | 49 | 84149 | 235 | 29490094 |
Retinal exudates | 152.30 | 12.13 | 61 | 84137 | 609 | 29489720 |
Drug abuse | 149.70 | 12.13 | 24 | 84174 | 79859 | 29410470 |
Proctalgia | 147.29 | 12.13 | 111 | 84087 | 4134 | 29486195 |
Fall | 140.61 | 12.13 | 179 | 84019 | 176999 | 29313330 |
Dry skin | 132.52 | 12.13 | 238 | 83960 | 23069 | 29467260 |
Completed suicide | 130.35 | 12.13 | 47 | 84151 | 90199 | 29400130 |
Haemolytic anaemia | 123.26 | 12.13 | 143 | 84055 | 9276 | 29481053 |
Haemorrhoids | 121.83 | 12.13 | 158 | 84040 | 11499 | 29478830 |
Disease progression | 121.16 | 12.13 | 41 | 84157 | 81875 | 29408454 |
Varices oesophageal | 117.52 | 12.13 | 86 | 84112 | 3060 | 29487269 |
Peritonitis bacterial | 113.98 | 12.13 | 109 | 84089 | 5647 | 29484682 |
Cardiac failure congestive | 112.09 | 12.13 | 39 | 84159 | 76542 | 29413787 |
Infusion related reaction | 110.84 | 12.13 | 3 | 84195 | 43883 | 29446446 |
Product use in unapproved indication | 108.37 | 12.13 | 56 | 84142 | 86819 | 29403510 |
Mood swings | 106.67 | 12.13 | 117 | 84081 | 7134 | 29483195 |
Cryoglobulinaemia | 105.39 | 12.13 | 38 | 84160 | 276 | 29490053 |
Drug hypersensitivity | 105.12 | 12.13 | 32 | 84166 | 68374 | 29421955 |
Acute kidney injury | 104.98 | 12.13 | 395 | 83803 | 264872 | 29225457 |
Porphyria non-acute | 104.89 | 12.13 | 42 | 84156 | 419 | 29489910 |
Viral mutation identified | 104.40 | 12.13 | 73 | 84125 | 2415 | 29487914 |
Off label use | 104.07 | 12.13 | 472 | 83726 | 300328 | 29190001 |
Red blood cell count decreased | 102.77 | 12.13 | 226 | 83972 | 25376 | 29464953 |
Depressed mood | 101.32 | 12.13 | 174 | 84024 | 16274 | 29474055 |
Hepatic cancer recurrent | 99.31 | 12.13 | 36 | 84162 | 266 | 29490063 |
Pancytopenia | 96.33 | 12.13 | 480 | 83718 | 82688 | 29407641 |
Drug ineffective | 95.28 | 12.13 | 1505 | 82693 | 361665 | 29128664 |
Rash pruritic | 92.71 | 12.13 | 200 | 83998 | 22163 | 29468166 |
Oxygen saturation decreased | 87.62 | 12.13 | 12 | 84186 | 44925 | 29445404 |
Retinal haemorrhage | 86.74 | 12.13 | 84 | 84114 | 4420 | 29485909 |
Drug eruption | 85.17 | 12.13 | 163 | 84035 | 16578 | 29473751 |
Weight decreased | 83.46 | 12.13 | 723 | 83475 | 150182 | 29340147 |
Thrombocytopenia | 80.40 | 12.13 | 657 | 83541 | 134166 | 29356163 |
Plasma cell myeloma | 79.72 | 12.13 | 7 | 84191 | 37108 | 29453221 |
Atrial fibrillation | 79.34 | 12.13 | 111 | 84087 | 105535 | 29384794 |
Asthenia | 78.65 | 12.13 | 947 | 83251 | 214303 | 29276026 |
Vogt-Koyanagi-Harada disease | 78.51 | 12.13 | 22 | 84176 | 59 | 29490270 |
Blood pressure increased | 77.60 | 12.13 | 58 | 84140 | 73745 | 29416584 |
Injection site rash | 77.30 | 12.13 | 71 | 84127 | 3493 | 29486836 |
Hepatorenal syndrome | 77.13 | 12.13 | 59 | 84139 | 2247 | 29488082 |
Portal hypertension | 76.69 | 12.13 | 70 | 84128 | 3416 | 29486913 |
Pneumonia | 76.05 | 12.13 | 567 | 83631 | 319605 | 29170724 |
Hepatitis C virus test positive | 74.18 | 12.13 | 29 | 84169 | 270 | 29490059 |
Hepatic hydrothorax | 70.75 | 12.13 | 18 | 84180 | 28 | 29490301 |
Erythema multiforme | 70.54 | 12.13 | 98 | 84100 | 7619 | 29482710 |
Renal impairment | 69.82 | 12.13 | 433 | 83765 | 80900 | 29409429 |
Electrocardiogram QT prolonged | 69.62 | 12.13 | 10 | 84188 | 36127 | 29454202 |
Therapeutic product effect incomplete | 68.86 | 12.13 | 14 | 84184 | 39291 | 29451038 |
Myocardial infarction | 68.69 | 12.13 | 131 | 84067 | 110165 | 29380164 |
Hospitalisation | 68.00 | 12.13 | 23 | 84175 | 45965 | 29444364 |
Mucosal inflammation | 67.75 | 12.13 | 6 | 84192 | 31589 | 29458740 |
Blood uric acid increased | 66.31 | 12.13 | 82 | 84116 | 5686 | 29484643 |
Portal vein thrombosis | 66.15 | 12.13 | 63 | 84135 | 3246 | 29487083 |
Hepatitis B reactivation | 63.65 | 12.13 | 61 | 84137 | 3168 | 29487161 |
General physical health deterioration | 62.45 | 12.13 | 124 | 84074 | 102733 | 29387596 |
Coronary artery disease | 62.11 | 12.13 | 24 | 84174 | 44166 | 29446163 |
Intentional product misuse | 61.44 | 12.13 | 12 | 84186 | 34649 | 29455680 |
Cardiac arrest | 61.23 | 12.13 | 93 | 84105 | 85498 | 29404831 |
Bradycardia | 61.09 | 12.13 | 58 | 84140 | 65571 | 29424758 |
Peripheral swelling | 59.72 | 12.13 | 56 | 84142 | 63683 | 29426646 |
Intentional overdose | 59.21 | 12.13 | 18 | 84180 | 38510 | 29451819 |
Injection site erythema | 59.20 | 12.13 | 126 | 84072 | 13830 | 29476499 |
Tachycardia | 57.47 | 12.13 | 73 | 84125 | 72337 | 29417992 |
Hyperkalaemia | 57.44 | 12.13 | 54 | 84144 | 61338 | 29428991 |
Therapy non-responder | 56.44 | 12.13 | 205 | 83993 | 30706 | 29459623 |
Foetal exposure during pregnancy | 55.44 | 12.13 | 14 | 84184 | 33853 | 29456476 |
Anger | 55.35 | 12.13 | 106 | 84092 | 10784 | 29479545 |
Weight increased | 55.13 | 12.13 | 83 | 84115 | 76584 | 29413745 |
Liver transplant rejection | 54.25 | 12.13 | 45 | 84153 | 1929 | 29488400 |
Suicidal ideation | 54.16 | 12.13 | 219 | 83979 | 34497 | 29455832 |
Hypertension | 53.93 | 12.13 | 162 | 84036 | 116452 | 29373877 |
Flushing | 53.63 | 12.13 | 9 | 84189 | 28983 | 29461346 |
Dry mouth | 52.77 | 12.13 | 159 | 84039 | 21625 | 29468704 |
Respiratory failure | 51.62 | 12.13 | 126 | 84072 | 97005 | 29393324 |
Hepatitis C RNA | 50.60 | 12.13 | 12 | 84186 | 11 | 29490318 |
Cardio-respiratory arrest | 50.35 | 12.13 | 42 | 84156 | 50559 | 29439770 |
Intentional product use issue | 49.21 | 12.13 | 30 | 84168 | 42468 | 29447861 |
Condition aggravated | 48.95 | 12.13 | 232 | 83966 | 146063 | 29344266 |
C-reactive protein increased | 47.53 | 12.13 | 34 | 84164 | 44229 | 29446100 |
Hepatic pain | 46.92 | 12.13 | 34 | 84164 | 1191 | 29489138 |
Pneumonia aspiration | 46.79 | 12.13 | 23 | 84175 | 36714 | 29453615 |
Hypoxia | 46.32 | 12.13 | 40 | 84158 | 47339 | 29442990 |
Rheumatoid arthritis | 45.95 | 12.13 | 17 | 84181 | 32135 | 29458194 |
Prostate cancer | 44.90 | 12.13 | 9 | 84189 | 25518 | 29464811 |
Anaphylactic reaction | 43.99 | 12.13 | 12 | 84186 | 27561 | 29462768 |
Neuropathy peripheral | 42.77 | 12.13 | 86 | 84112 | 70941 | 29419388 |
Blood bilirubin unconjugated increased | 42.72 | 12.13 | 24 | 84174 | 535 | 29489794 |
Malaise | 42.53 | 12.13 | 664 | 83534 | 158938 | 29331391 |
Alopecia | 42.24 | 12.13 | 135 | 84063 | 18949 | 29471380 |
Blood pressure fluctuation | 42.05 | 12.13 | 4 | 84194 | 19890 | 29470439 |
Bleeding varicose vein | 41.86 | 12.13 | 19 | 84179 | 264 | 29490065 |
Gastric varices haemorrhage | 41.50 | 12.13 | 18 | 84180 | 223 | 29490106 |
Pulmonary embolism | 40.88 | 12.13 | 99 | 84099 | 76435 | 29413894 |
Cerebrovascular accident | 40.67 | 12.13 | 100 | 84098 | 76811 | 29413518 |
Asthma | 40.45 | 12.13 | 23 | 84175 | 33826 | 29456503 |
Viral load | 40.44 | 12.13 | 12 | 84186 | 42 | 29490287 |
Pregnancy of partner | 39.63 | 12.13 | 19 | 84179 | 301 | 29490028 |
Child-Pugh-Turcotte score increased | 39.52 | 12.13 | 10 | 84188 | 15 | 29490314 |
Heart rate decreased | 39.44 | 12.13 | 11 | 84187 | 24901 | 29465428 |
Hypersensitivity | 39.26 | 12.13 | 56 | 84142 | 52847 | 29437482 |
Yellow skin | 39.26 | 12.13 | 37 | 84161 | 1881 | 29488448 |
Focal segmental glomerulosclerosis | 39.19 | 12.13 | 36 | 84162 | 1771 | 29488558 |
Joint swelling | 38.37 | 12.13 | 51 | 84147 | 49579 | 29440750 |
Cardiac failure | 38.19 | 12.13 | 108 | 84090 | 79179 | 29411150 |
Therapeutic product effect decreased | 38.18 | 12.13 | 18 | 84180 | 29433 | 29460896 |
Basedow's disease | 38.07 | 12.13 | 12 | 84186 | 54 | 29490275 |
Wrong technique in product usage process | 38.07 | 12.13 | 21 | 84177 | 31407 | 29458922 |
Contraindicated product administered | 37.76 | 12.13 | 4 | 84194 | 18262 | 29472067 |
Skin disorder | 37.28 | 12.13 | 94 | 84104 | 11524 | 29478805 |
Disturbance in attention | 36.53 | 12.13 | 139 | 84059 | 21285 | 29469044 |
Hyponatraemia | 36.50 | 12.13 | 87 | 84111 | 67546 | 29422783 |
Encephalopathy | 36.47 | 12.13 | 180 | 84018 | 30863 | 29459466 |
Wheezing | 36.38 | 12.13 | 25 | 84173 | 33215 | 29457114 |
Angioedema | 36.29 | 12.13 | 23 | 84175 | 31892 | 29458437 |
Osteonecrosis of jaw | 35.76 | 12.13 | 3 | 84195 | 16507 | 29473822 |
Sedation | 35.50 | 12.13 | 4 | 84194 | 17401 | 29472928 |
Cardiogenic shock | 35.39 | 12.13 | 6 | 84192 | 19184 | 29471145 |
Chronic obstructive pulmonary disease | 34.92 | 12.13 | 39 | 84159 | 40916 | 29449413 |
Neuroleptic malignant syndrome | 34.80 | 12.13 | 3 | 84195 | 16145 | 29474184 |
Abortion spontaneous | 34.63 | 12.13 | 11 | 84187 | 51 | 29490278 |
Vomiting | 34.56 | 12.13 | 819 | 83379 | 211441 | 29278888 |
Facial paralysis | 34.19 | 12.13 | 81 | 84117 | 9548 | 29480781 |
Hypoglycaemia | 34.10 | 12.13 | 53 | 84145 | 48293 | 29442036 |
Cardiac disorder | 33.43 | 12.13 | 34 | 84164 | 37229 | 29453100 |
Neutropenia | 33.19 | 12.13 | 543 | 83655 | 131168 | 29359161 |
Mental disorder | 32.97 | 12.13 | 96 | 84102 | 12809 | 29477520 |
Glomerulonephritis membranoproliferative | 32.58 | 12.13 | 18 | 84180 | 388 | 29489941 |
Chronic hepatitis C | 32.45 | 12.13 | 17 | 84181 | 328 | 29490001 |
Biliary colic | 32.42 | 12.13 | 24 | 84174 | 869 | 29489460 |
Hepatic fibrosis | 32.30 | 12.13 | 43 | 84155 | 3209 | 29487120 |
Alopecia universalis | 32.29 | 12.13 | 11 | 84187 | 66 | 29490263 |
Gastrointestinal haemorrhage | 32.25 | 12.13 | 117 | 84081 | 79416 | 29410913 |
Haemolysis | 32.07 | 12.13 | 65 | 84133 | 6891 | 29483438 |
Drug reaction with eosinophilia and systemic symptoms | 31.95 | 12.13 | 161 | 84037 | 27831 | 29462498 |
Pain in extremity | 31.93 | 12.13 | 184 | 84014 | 110249 | 29380080 |
Myalgia | 31.58 | 12.13 | 336 | 83862 | 73683 | 29416646 |
Hepatitis C RNA fluctuation | 31.56 | 12.13 | 7 | 84191 | 3 | 29490326 |
Haematuria | 31.50 | 12.13 | 48 | 84150 | 44091 | 29446238 |
Pneumocystis jirovecii pneumonia | 31.50 | 12.13 | 5 | 84193 | 16774 | 29473555 |
Sarcoidosis | 31.10 | 12.13 | 38 | 84160 | 2602 | 29487727 |
Pulmonary oedema | 30.96 | 12.13 | 46 | 84152 | 42689 | 29447640 |
Affect lability | 30.79 | 12.13 | 43 | 84155 | 3359 | 29486970 |
Constipation | 30.49 | 12.13 | 195 | 84003 | 113965 | 29376364 |
Muscular weakness | 30.27 | 12.13 | 84 | 84114 | 61968 | 29428361 |
Product prescribing error | 30.26 | 12.13 | 7 | 84191 | 17969 | 29472360 |
Optic ischaemic neuropathy | 29.94 | 12.13 | 32 | 84166 | 1894 | 29488435 |
Transfusion | 29.92 | 12.13 | 65 | 84133 | 7233 | 29483096 |
Rhabdomyolysis | 29.89 | 12.13 | 82 | 84116 | 60726 | 29429603 |
Clostridium difficile infection | 29.87 | 12.13 | 5 | 84193 | 16136 | 29474193 |
Ocular icterus | 29.78 | 12.13 | 37 | 84161 | 2578 | 29487751 |
Mood altered | 29.63 | 12.13 | 69 | 84129 | 8042 | 29482287 |
Hepatitis C virus test | 29.36 | 12.13 | 10 | 84188 | 60 | 29490269 |
Pyrexia | 29.25 | 12.13 | 1046 | 83152 | 286576 | 29203753 |
Acute on chronic liver failure | 28.96 | 12.13 | 11 | 84187 | 94 | 29490235 |
Product use issue | 28.70 | 12.13 | 65 | 84133 | 51379 | 29438950 |
Injection site ulcer | 28.42 | 12.13 | 14 | 84184 | 236 | 29490093 |
Psychotic disorder | 28.31 | 12.13 | 124 | 84074 | 20230 | 29470099 |
Blood pressure decreased | 28.28 | 12.13 | 54 | 84144 | 45423 | 29444906 |
Retinal detachment | 28.10 | 12.13 | 49 | 84149 | 4637 | 29485692 |
Metabolic acidosis | 27.81 | 12.13 | 40 | 84158 | 37622 | 29452707 |
Respiratory arrest | 27.52 | 12.13 | 20 | 84178 | 25813 | 29464516 |
Musculoskeletal stiffness | 27.45 | 12.13 | 40 | 84158 | 37418 | 29452911 |
International normalised ratio increased | 27.32 | 12.13 | 53 | 84145 | 44319 | 29446010 |
Bilirubin conjugated increased | 27.10 | 12.13 | 38 | 84160 | 2979 | 29487350 |
Arthropathy | 26.69 | 12.13 | 14 | 84184 | 21540 | 29468789 |
Ammonia increased | 26.62 | 12.13 | 44 | 84154 | 3987 | 29486342 |
Device related infection | 26.50 | 12.13 | 6 | 84192 | 15630 | 29474699 |
Injection site reaction | 26.47 | 12.13 | 81 | 84117 | 11107 | 29479222 |
Anorectal disorder | 26.36 | 12.13 | 22 | 84176 | 951 | 29489378 |
Eczema | 26.34 | 12.13 | 93 | 84105 | 13733 | 29476596 |
Hypocalcaemia | 26.22 | 12.13 | 13 | 84185 | 20652 | 29469677 |
Chills | 26.04 | 12.13 | 314 | 83884 | 70986 | 29419343 |
Therapeutic embolisation | 25.88 | 12.13 | 14 | 84184 | 289 | 29490040 |
Renal disorder | 25.81 | 12.13 | 130 | 84068 | 22465 | 29467864 |
Sleep apnoea syndrome | 25.66 | 12.13 | 9 | 84189 | 17590 | 29472739 |
Sepsis | 25.63 | 12.13 | 271 | 83927 | 142411 | 29347918 |
Acute myocardial infarction | 25.58 | 12.13 | 63 | 84135 | 48375 | 29441954 |
Acute stress disorder | 25.38 | 12.13 | 11 | 84187 | 136 | 29490193 |
Testicular germ cell tumour mixed | 25.19 | 12.13 | 7 | 84191 | 18 | 29490311 |
Injection site pruritus | 25.02 | 12.13 | 53 | 84145 | 5796 | 29484533 |
Acute myeloid leukaemia | 24.85 | 12.13 | 8 | 84190 | 16505 | 29473824 |
Orthostatic hypotension | 24.79 | 12.13 | 17 | 84181 | 22612 | 29467717 |
Haemophilic arthropathy | 24.78 | 12.13 | 10 | 84188 | 102 | 29490227 |
Homicidal ideation | 24.50 | 12.13 | 33 | 84165 | 2491 | 29487838 |
Blood cholesterol increased | 24.48 | 12.13 | 7 | 84191 | 15588 | 29474741 |
Urinary retention | 24.43 | 12.13 | 33 | 84165 | 31865 | 29458464 |
Heart rate irregular | 24.42 | 12.13 | 4 | 84194 | 13113 | 29477216 |
Labelled drug-drug interaction medication error | 24.29 | 12.13 | 3 | 84195 | 12156 | 29478173 |
Exposure via body fluid | 23.87 | 12.13 | 10 | 84188 | 113 | 29490216 |
Depressed level of consciousness | 23.74 | 12.13 | 43 | 84155 | 36899 | 29453430 |
Ejection fraction decreased | 23.59 | 12.13 | 8 | 84190 | 15970 | 29474359 |
Thrombosis | 23.51 | 12.13 | 55 | 84143 | 42990 | 29447339 |
Coma hepatic | 23.43 | 12.13 | 15 | 84183 | 427 | 29489902 |
Genital herpes simplex | 23.41 | 12.13 | 10 | 84188 | 119 | 29490210 |
Complications of transplanted liver | 23.41 | 12.13 | 12 | 84186 | 221 | 29490108 |
Nasopharyngitis | 23.38 | 12.13 | 89 | 84109 | 59576 | 29430753 |
Ventricular tachycardia | 23.37 | 12.13 | 18 | 84180 | 22556 | 29467773 |
Herpes zoster | 23.10 | 12.13 | 31 | 84167 | 30021 | 29460308 |
Type 1 diabetes mellitus | 23.02 | 12.13 | 39 | 84159 | 3605 | 29486724 |
Alpha 1 foetoprotein increased | 23.00 | 12.13 | 17 | 84181 | 614 | 29489715 |
Acute respiratory failure | 22.66 | 12.13 | 25 | 84173 | 26377 | 29463952 |
Mobility decreased | 22.58 | 12.13 | 24 | 84174 | 25756 | 29464573 |
Basal cell carcinoma | 22.44 | 12.13 | 10 | 84188 | 16900 | 29473429 |
Seizure | 22.41 | 12.13 | 164 | 84034 | 92959 | 29397370 |
Psoriatic arthropathy | 22.32 | 12.13 | 7 | 84191 | 14684 | 29475645 |
Exposure via direct contact | 22.30 | 12.13 | 7 | 84191 | 31 | 29490298 |
Neurotoxicity | 22.13 | 12.13 | 7 | 84191 | 14606 | 29475723 |
Osteoarthritis | 22.06 | 12.13 | 12 | 84186 | 18091 | 29472238 |
Pleural effusion | 21.75 | 12.13 | 118 | 84080 | 71790 | 29418539 |
Toxic skin eruption | 21.57 | 12.13 | 69 | 84129 | 9688 | 29480641 |
Emotional disorder | 21.46 | 12.13 | 45 | 84153 | 4886 | 29485443 |
Somnolence | 21.41 | 12.13 | 168 | 84030 | 93787 | 29396542 |
Ammonia abnormal | 21.31 | 12.13 | 8 | 84190 | 66 | 29490263 |
Porphyria | 21.29 | 12.13 | 7 | 84191 | 37 | 29490292 |
Upper respiratory tract infection | 21.24 | 12.13 | 28 | 84170 | 27321 | 29463008 |
Diverticulitis | 21.19 | 12.13 | 12 | 84186 | 17692 | 29472637 |
Urticaria | 21.11 | 12.13 | 82 | 84116 | 54578 | 29435751 |
Synovitis | 21.00 | 12.13 | 3 | 84195 | 10887 | 29479442 |
Respiratory distress | 20.96 | 12.13 | 37 | 84161 | 32069 | 29458260 |
Hepatic neoplasm | 20.94 | 12.13 | 26 | 84172 | 1810 | 29488519 |
Toxic epidermal necrolysis | 20.75 | 12.13 | 13 | 84185 | 18140 | 29472189 |
Autoimmune hepatitis | 20.74 | 12.13 | 37 | 84161 | 3565 | 29486764 |
Alanine aminotransferase increased | 20.72 | 12.13 | 300 | 83898 | 70644 | 29419685 |
Injection site pain | 20.64 | 12.13 | 38 | 84160 | 32408 | 29457921 |
Normal newborn | 20.55 | 12.13 | 10 | 84188 | 164 | 29490165 |
Facial paresis | 20.44 | 12.13 | 31 | 84167 | 2610 | 29487719 |
Asterixis | 20.29 | 12.13 | 20 | 84178 | 1075 | 29489254 |
Premature baby | 20.27 | 12.13 | 12 | 84186 | 17268 | 29473061 |
Memory impairment | 20.22 | 12.13 | 175 | 84023 | 36295 | 29454034 |
Genital herpes | 20.20 | 12.13 | 15 | 84183 | 546 | 29489783 |
Lethargy | 20.14 | 12.13 | 179 | 84019 | 37401 | 29452928 |
Myelodysplastic syndrome | 19.99 | 12.13 | 13 | 84185 | 17781 | 29472548 |
Product quality issue | 19.98 | 12.13 | 94 | 84104 | 15801 | 29474528 |
Liver disorder | 19.71 | 12.13 | 141 | 84057 | 27608 | 29462721 |
Tubulointerstitial nephritis | 19.67 | 12.13 | 13 | 84185 | 17630 | 29472699 |
Anticoagulation drug level below therapeutic | 19.63 | 12.13 | 16 | 84182 | 669 | 29489660 |
Hypervolaemia | 19.46 | 12.13 | 13 | 84185 | 17532 | 29472797 |
Fat intolerance | 19.46 | 12.13 | 4 | 84194 | 0 | 29490329 |
Pregnancy | 19.39 | 12.13 | 11 | 84187 | 250 | 29490079 |
Squamous cell carcinoma | 19.36 | 12.13 | 3 | 84195 | 10248 | 29480081 |
Palmar-plantar erythrodysaesthesia syndrome | 19.16 | 12.13 | 9 | 84189 | 14750 | 29475579 |
Liver transplant failure | 19.05 | 12.13 | 8 | 84190 | 91 | 29490238 |
Overdose | 18.99 | 12.13 | 141 | 84057 | 79678 | 29410651 |
Sopor | 18.93 | 12.13 | 4 | 84194 | 10930 | 29479399 |
Ischaemic stroke | 18.88 | 12.13 | 11 | 84187 | 15966 | 29474363 |
Photophobia | 18.71 | 12.13 | 48 | 84150 | 5947 | 29484382 |
Poisoning | 18.71 | 12.13 | 3 | 84195 | 9990 | 29480339 |
Ventricular fibrillation | 18.57 | 12.13 | 11 | 84187 | 15822 | 29474507 |
Sudden visual loss | 18.54 | 12.13 | 5 | 84193 | 11 | 29490318 |
Chest discomfort | 18.40 | 12.13 | 68 | 84130 | 45915 | 29444414 |
Angina pectoris | 18.27 | 12.13 | 32 | 84166 | 27818 | 29462511 |
Mitochondrial toxicity | 18.23 | 12.13 | 28 | 84170 | 2383 | 29487946 |
Diabetic hyperglycaemic coma | 18.20 | 12.13 | 6 | 84192 | 32 | 29490297 |
Coma | 18.07 | 12.13 | 55 | 84143 | 39395 | 29450934 |
Blood pressure systolic increased | 18.00 | 12.13 | 13 | 84185 | 16832 | 29473497 |
Circulatory collapse | 17.96 | 12.13 | 16 | 84182 | 18657 | 29471672 |
Sinusitis | 17.88 | 12.13 | 45 | 84153 | 34305 | 29456024 |
Productive cough | 17.83 | 12.13 | 39 | 84159 | 31220 | 29459109 |
Hip fracture | 17.83 | 12.13 | 4 | 84194 | 10488 | 29479841 |
Oral lichen planus | 17.74 | 12.13 | 9 | 84189 | 162 | 29490167 |
Gastric varices | 17.73 | 12.13 | 12 | 84186 | 376 | 29489953 |
Alpha 1 foetoprotein abnormal | 17.69 | 12.13 | 5 | 84193 | 14 | 29490315 |
Hepatic lesion | 17.68 | 12.13 | 32 | 84166 | 3118 | 29487211 |
Feeling cold | 17.66 | 12.13 | 62 | 84136 | 9129 | 29481200 |
Cholelithiasis | 17.65 | 12.13 | 102 | 84096 | 18570 | 29471759 |
Anaphylactic shock | 17.51 | 12.13 | 8 | 84190 | 13328 | 29477001 |
Blood iron increased | 17.45 | 12.13 | 16 | 84182 | 785 | 29489544 |
Hyperlipidaemia | 17.42 | 12.13 | 7 | 84191 | 12583 | 29477746 |
Photosensitivity reaction | 17.40 | 12.13 | 62 | 84136 | 9196 | 29481133 |
Thirst | 17.27 | 12.13 | 49 | 84149 | 6442 | 29483887 |
Bacterascites | 17.23 | 12.13 | 4 | 84194 | 3 | 29490326 |
Neutropenic sepsis | 17.09 | 12.13 | 6 | 84192 | 11721 | 29478608 |
Disease recurrence | 17.09 | 12.13 | 90 | 84108 | 15824 | 29474505 |
Paraesthesia | 17.04 | 12.13 | 87 | 84111 | 53758 | 29436571 |
Thought blocking | 16.90 | 12.13 | 8 | 84190 | 123 | 29490206 |
Blood disorder | 16.84 | 12.13 | 30 | 84168 | 2887 | 29487442 |
Portal hypertensive gastropathy | 16.84 | 12.13 | 13 | 84185 | 502 | 29489827 |
Haematemesis | 16.83 | 12.13 | 124 | 84074 | 24502 | 29465827 |
Intestinal obstruction | 16.82 | 12.13 | 18 | 84180 | 19259 | 29471070 |
Parosmia | 16.79 | 12.13 | 21 | 84177 | 1473 | 29488856 |
Drug interaction | 16.71 | 12.13 | 431 | 83767 | 196954 | 29293375 |
Pityriasis | 16.70 | 12.13 | 4 | 84194 | 4 | 29490325 |
Chronic kidney disease | 16.51 | 12.13 | 51 | 84147 | 36365 | 29453964 |
Hepatitis E | 16.42 | 12.13 | 22 | 84176 | 1652 | 29488677 |
Unresponsive to stimuli | 16.36 | 12.13 | 29 | 84169 | 25097 | 29465232 |
Papilloedema | 16.23 | 12.13 | 26 | 84172 | 2294 | 29488035 |
Feeling abnormal | 16.20 | 12.13 | 231 | 83967 | 54214 | 29436115 |
Dyskinesia | 16.14 | 12.13 | 20 | 84178 | 20041 | 29470288 |
Haemorrhoidal haemorrhage | 16.03 | 12.13 | 30 | 84168 | 2999 | 29487330 |
Pneumonitis | 15.99 | 12.13 | 35 | 84163 | 28009 | 29462320 |
Oral herpes | 15.95 | 12.13 | 38 | 84160 | 4494 | 29485835 |
Mitral valve incompetence | 15.92 | 12.13 | 9 | 84189 | 13284 | 29477045 |
Deafness congenital | 15.84 | 12.13 | 7 | 84191 | 91 | 29490238 |
Emotional distress | 15.81 | 12.13 | 10 | 84188 | 13885 | 29476444 |
Optic neuropathy | 15.80 | 12.13 | 22 | 84176 | 1713 | 29488616 |
Cutaneous sarcoidosis | 15.72 | 12.13 | 8 | 84190 | 145 | 29490184 |
Tachypnoea | 15.71 | 12.13 | 12 | 84186 | 15103 | 29475226 |
Interstitial lung disease | 15.70 | 12.13 | 98 | 84100 | 57620 | 29432709 |
Adrenal insufficiency | 15.67 | 12.13 | 6 | 84192 | 11108 | 29479221 |
Injection site necrosis | 15.62 | 12.13 | 11 | 84187 | 368 | 29489961 |
Hypomagnesaemia | 15.59 | 12.13 | 16 | 84182 | 17452 | 29472877 |
Limb discomfort | 15.57 | 12.13 | 4 | 84194 | 9564 | 29480765 |
Hydrocholecystis | 15.55 | 12.13 | 10 | 84188 | 287 | 29490042 |
Nephritic syndrome | 15.33 | 12.13 | 6 | 84192 | 56 | 29490273 |
Mouth ulceration | 15.10 | 12.13 | 64 | 84134 | 10291 | 29480038 |
Bronchitis | 15.09 | 12.13 | 54 | 84144 | 36814 | 29453515 |
Extrapyramidal disorder | 15.02 | 12.13 | 6 | 84192 | 10825 | 29479504 |
Nasal congestion | 15.00 | 12.13 | 19 | 84179 | 18860 | 29471469 |
Status epilepticus | 14.93 | 12.13 | 6 | 84192 | 10788 | 29479541 |
Skin cancer | 14.86 | 12.13 | 3 | 84195 | 8465 | 29481864 |
Hepatic amoebiasis | 14.80 | 12.13 | 6 | 84192 | 62 | 29490267 |
Injection site dermatitis | 14.77 | 12.13 | 4 | 84194 | 9 | 29490320 |
Body temperature decreased | 14.64 | 12.13 | 6 | 84192 | 10658 | 29479671 |
Viral load undetectable | 14.59 | 12.13 | 3 | 84195 | 0 | 29490329 |
Ear injury | 14.54 | 12.13 | 5 | 84193 | 31 | 29490298 |
Therapy responder | 14.50 | 12.13 | 8 | 84190 | 172 | 29490157 |
Aspergillus infection | 14.45 | 12.13 | 6 | 84192 | 10575 | 29479754 |
Myopathy | 14.34 | 12.13 | 6 | 84192 | 10527 | 29479802 |
Borderline personality disorder | 14.32 | 12.13 | 10 | 84188 | 330 | 29489999 |
Loss of personal independence in daily activities | 14.30 | 12.13 | 32 | 84166 | 25408 | 29464921 |
Nephrotic syndrome | 14.21 | 12.13 | 45 | 84153 | 6283 | 29484046 |
Gait disturbance | 14.11 | 12.13 | 137 | 84061 | 73212 | 29417117 |
Fungal infection | 14.05 | 12.13 | 11 | 84187 | 13674 | 29476655 |
Infective spondylitis | 14.05 | 12.13 | 8 | 84190 | 183 | 29490146 |
Dysphagia | 14.05 | 12.13 | 95 | 84103 | 54831 | 29435498 |
Left ventricular dysfunction | 13.96 | 12.13 | 4 | 84194 | 8898 | 29481431 |
Gene mutation identification test positive | 13.95 | 12.13 | 7 | 84191 | 123 | 29490206 |
Procalcitonin | 13.95 | 12.13 | 4 | 84194 | 12 | 29490317 |
Pulmonary tuberculosis | 13.93 | 12.13 | 35 | 84163 | 4280 | 29486049 |
Bronchospasm | 13.86 | 12.13 | 5 | 84193 | 9604 | 29480725 |
Osteonecrosis | 13.72 | 12.13 | 11 | 84187 | 13508 | 29476821 |
Oedema due to hepatic disease | 13.71 | 12.13 | 4 | 84194 | 13 | 29490316 |
Fundoscopy abnormal | 13.71 | 12.13 | 4 | 84194 | 13 | 29490316 |
Lymphocyte count decreased | 13.70 | 12.13 | 21 | 84177 | 19250 | 29471079 |
Sudden hearing loss | 13.70 | 12.13 | 14 | 84184 | 786 | 29489543 |
COVID-19 pneumonia | 13.66 | 12.13 | 5 | 84193 | 9517 | 29480812 |
Oesophageal variceal ligation | 13.64 | 12.13 | 6 | 84192 | 77 | 29490252 |
Urinary tract infection | 13.56 | 12.13 | 136 | 84062 | 72218 | 29418111 |
Retinal vein thrombosis | 13.51 | 12.13 | 10 | 84188 | 362 | 29489967 |
Impaired work ability | 13.50 | 12.13 | 41 | 84157 | 5599 | 29484730 |
Generalised tonic-clonic seizure | 13.47 | 12.13 | 21 | 84177 | 19118 | 29471211 |
Delirium | 13.42 | 12.13 | 62 | 84136 | 39335 | 29450994 |
Gallbladder cancer | 13.31 | 12.13 | 8 | 84190 | 203 | 29490126 |
Inflammation | 13.26 | 12.13 | 28 | 84170 | 22700 | 29467629 |
Atrial flutter | 13.25 | 12.13 | 12 | 84186 | 13882 | 29476447 |
Hepatitis chronic active | 13.24 | 12.13 | 5 | 84193 | 42 | 29490287 |
Skin irritation | 13.18 | 12.13 | 35 | 84163 | 4426 | 29485903 |
Exposure during pregnancy | 13.13 | 12.13 | 4 | 84194 | 8550 | 29481779 |
Hallucination, visual | 13.13 | 12.13 | 14 | 84184 | 15001 | 29475328 |
Anxiety | 13.12 | 12.13 | 327 | 83871 | 85038 | 29405291 |
Clostridium difficile colitis | 13.09 | 12.13 | 11 | 84187 | 13201 | 29477128 |
Depressive symptom | 13.07 | 12.13 | 20 | 84178 | 1697 | 29488632 |
Oesophagitis | 13.00 | 12.13 | 9 | 84189 | 11914 | 29478415 |
Neutralising antibodies positive | 12.99 | 12.13 | 6 | 84192 | 87 | 29490242 |
Mesenteric vein thrombosis | 12.96 | 12.13 | 11 | 84187 | 487 | 29489842 |
Tongue ulceration | 12.92 | 12.13 | 16 | 84182 | 1111 | 29489218 |
Ventricular extrasystoles | 12.91 | 12.13 | 7 | 84191 | 10575 | 29479754 |
Infection | 12.88 | 12.13 | 148 | 84050 | 76603 | 29413726 |
Drug level increased | 12.86 | 12.13 | 21 | 84177 | 18766 | 29471563 |
Anti-erythropoietin antibody positive | 12.86 | 12.13 | 14 | 84184 | 846 | 29489483 |
Hot flush | 12.85 | 12.13 | 14 | 84184 | 14856 | 29475473 |
White blood cell count increased | 12.81 | 12.13 | 59 | 84139 | 37457 | 29452872 |
Chromaturia | 12.80 | 12.13 | 71 | 84127 | 12731 | 29477598 |
Hypokalaemia | 12.76 | 12.13 | 87 | 84111 | 50116 | 29440213 |
Liver function test abnormal | 12.76 | 12.13 | 41 | 84157 | 28877 | 29461452 |
Lung disorder | 12.74 | 12.13 | 44 | 84154 | 30318 | 29460011 |
Granulocyte count decreased | 12.70 | 12.13 | 12 | 84186 | 612 | 29489717 |
Hepatopulmonary syndrome | 12.69 | 12.13 | 4 | 84194 | 18 | 29490311 |
Urinary incontinence | 12.67 | 12.13 | 17 | 84181 | 16464 | 29473865 |
Pemphigoid | 12.67 | 12.13 | 3 | 84195 | 7578 | 29482751 |
Aphasia | 12.64 | 12.13 | 22 | 84176 | 19176 | 29471153 |
Bronchopulmonary aspergillosis | 12.58 | 12.13 | 10 | 84188 | 12334 | 29477995 |
Vision blurred | 12.57 | 12.13 | 172 | 84026 | 40004 | 29450325 |
Transaminases decreased | 12.52 | 12.13 | 3 | 84195 | 3 | 29490326 |
Hypercatabolism | 12.52 | 12.13 | 3 | 84195 | 3 | 29490326 |
Delusional disorder, erotomanic type | 12.52 | 12.13 | 3 | 84195 | 3 | 29490326 |
Rales | 12.49 | 12.13 | 3 | 84195 | 7507 | 29482822 |
Neoplasm malignant | 12.47 | 12.13 | 18 | 84180 | 16907 | 29473422 |
Remission not achieved | 12.46 | 12.13 | 6 | 84192 | 96 | 29490233 |
Post procedural haemorrhage | 12.45 | 12.13 | 3 | 84195 | 7488 | 29482841 |
Alcoholism | 12.43 | 12.13 | 25 | 84173 | 2636 | 29487693 |
Glossodynia | 12.30 | 12.13 | 28 | 84170 | 3215 | 29487114 |
Aplasia pure red cell | 12.29 | 12.13 | 39 | 84159 | 5452 | 29484877 |
Hypernatraemia | 12.19 | 12.13 | 3 | 84195 | 7383 | 29482946 |
Respiratory tract infection | 12.18 | 12.13 | 16 | 84182 | 15635 | 29474694 |
Rhinorrhoea | 12.15 | 12.13 | 27 | 84171 | 21492 | 29468837 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Anaemia | 5001.81 | 11.09 | 4686 | 114228 | 373994 | 64005824 |
Hepatocellular carcinoma | 2345.88 | 11.09 | 793 | 118121 | 7610 | 64372208 |
Hepatitis C | 2298.76 | 11.09 | 837 | 118077 | 10178 | 64369640 |
Haemoglobin decreased | 1388.42 | 11.09 | 1751 | 117163 | 193312 | 64186506 |
White blood cell count decreased | 1382.66 | 11.09 | 1575 | 117339 | 156262 | 64223556 |
Platelet count decreased | 1051.43 | 11.09 | 1415 | 117499 | 166296 | 64213522 |
Hepatic cirrhosis | 884.33 | 11.09 | 570 | 118344 | 25728 | 64354090 |
Rash | 849.26 | 11.09 | 2293 | 116621 | 456256 | 63923562 |
Ascites | 836.01 | 11.09 | 781 | 118133 | 61220 | 64318598 |
Neutrophil count decreased | 774.34 | 11.09 | 828 | 118086 | 76368 | 64303450 |
Blood bilirubin increased | 694.41 | 11.09 | 682 | 118232 | 56871 | 64322947 |
Hepatic encephalopathy | 660.27 | 11.09 | 437 | 118477 | 20629 | 64359189 |
Fatigue | 640.02 | 11.09 | 2896 | 116018 | 745834 | 63633984 |
Hyperbilirubinaemia | 616.90 | 11.09 | 420 | 118494 | 20785 | 64359033 |
Jaundice | 570.53 | 11.09 | 567 | 118347 | 47945 | 64331873 |
Insomnia | 560.02 | 11.09 | 1169 | 117745 | 196667 | 64183151 |
Retinopathy | 553.66 | 11.09 | 215 | 118699 | 3150 | 64376668 |
Influenza like illness | 524.18 | 11.09 | 607 | 118307 | 61095 | 64318723 |
Hepatic failure | 523.49 | 11.09 | 576 | 118338 | 54818 | 64325000 |
Depression | 494.22 | 11.09 | 1062 | 117852 | 182229 | 64197589 |
Pruritus | 485.76 | 11.09 | 1469 | 117445 | 310931 | 64068887 |
Hyperuricaemia | 479.35 | 11.09 | 274 | 118640 | 9917 | 64369901 |
Decreased appetite | 466.97 | 11.09 | 1354 | 117560 | 279935 | 64099883 |
Anal pruritus | 442.41 | 11.09 | 123 | 118791 | 557 | 64379261 |
Genotype drug resistance test positive | 402.85 | 11.09 | 126 | 118788 | 918 | 64378900 |
Leukopenia | 401.16 | 11.09 | 691 | 118223 | 100551 | 64279267 |
Toxicity to various agents | 389.04 | 11.09 | 96 | 118818 | 363417 | 64016401 |
Anorectal discomfort | 369.73 | 11.09 | 154 | 118760 | 2731 | 64377087 |
Dysgeusia | 363.40 | 11.09 | 441 | 118473 | 46606 | 64333212 |
Hepatic cancer | 360.36 | 11.09 | 204 | 118710 | 7244 | 64372574 |
Oesophageal varices haemorrhage | 338.90 | 11.09 | 155 | 118759 | 3474 | 64376344 |
Irritability | 319.51 | 11.09 | 366 | 118548 | 36380 | 64343438 |
Viral load increased | 316.17 | 11.09 | 132 | 118782 | 2355 | 64377463 |
Haemolytic anaemia | 308.99 | 11.09 | 248 | 118666 | 15805 | 64364013 |
Infusion related reaction | 286.75 | 11.09 | 3 | 118911 | 164464 | 64215354 |
Drug hypersensitivity | 282.71 | 11.09 | 49 | 118865 | 237766 | 64142052 |
Pancytopenia | 277.02 | 11.09 | 730 | 118184 | 142579 | 64237239 |
Completed suicide | 265.08 | 11.09 | 47 | 118867 | 224367 | 64155451 |
Hepatitis C RNA positive | 258.73 | 11.09 | 65 | 118849 | 179 | 64379639 |
Thrombocytopenia | 256.93 | 11.09 | 951 | 117963 | 222850 | 64156968 |
Nausea | 245.87 | 11.09 | 2364 | 116550 | 783436 | 63596382 |
Liver transplant | 239.18 | 11.09 | 127 | 118787 | 3965 | 64375853 |
Proctalgia | 222.82 | 11.09 | 151 | 118763 | 7408 | 64372410 |
Asthenia | 218.22 | 11.09 | 1442 | 117472 | 426602 | 63953216 |
Fall | 213.98 | 11.09 | 273 | 118641 | 416553 | 63963265 |
Virologic failure | 212.32 | 11.09 | 111 | 118803 | 3355 | 64376463 |
Joint swelling | 206.05 | 11.09 | 70 | 118844 | 215312 | 64164506 |
Hepatitis C RNA increased | 200.29 | 11.09 | 59 | 118855 | 341 | 64379477 |
Dry skin | 195.69 | 11.09 | 344 | 118570 | 50817 | 64329001 |
Cryoglobulinaemia | 191.98 | 11.09 | 65 | 118849 | 625 | 64379193 |
Renal impairment | 188.93 | 11.09 | 613 | 118301 | 134404 | 64245414 |
Rheumatoid arthritis | 186.32 | 11.09 | 38 | 118876 | 164256 | 64215562 |
Varices oesophageal | 181.78 | 11.09 | 115 | 118799 | 5015 | 64374803 |
Retinal exudates | 176.93 | 11.09 | 70 | 118844 | 1080 | 64378738 |
Death | 174.32 | 11.09 | 396 | 118518 | 482309 | 63897509 |
Treatment failure | 172.19 | 11.09 | 540 | 118374 | 116276 | 64263542 |
Malignant neoplasm progression | 171.00 | 11.09 | 9 | 118905 | 112862 | 64266956 |
Vogt-Koyanagi-Harada disease | 169.61 | 11.09 | 45 | 118869 | 164 | 64379654 |
Hypotension | 169.35 | 11.09 | 276 | 118638 | 380698 | 63999120 |
Contraindicated product administered | 168.53 | 11.09 | 7 | 118907 | 107822 | 64271996 |
Peripheral swelling | 167.96 | 11.09 | 88 | 118826 | 209065 | 64170753 |
Retinal haemorrhage | 161.19 | 11.09 | 123 | 118791 | 7275 | 64372543 |
Synovitis | 159.83 | 11.09 | 5 | 118909 | 99085 | 64280733 |
Red blood cell count decreased | 159.35 | 11.09 | 305 | 118609 | 48081 | 64331737 |
Porphyria non-acute | 158.57 | 11.09 | 57 | 118857 | 664 | 64379154 |
Drug abuse | 157.81 | 11.09 | 27 | 118887 | 132347 | 64247471 |
Febrile neutropenia | 156.62 | 11.09 | 75 | 118839 | 187582 | 64192236 |
Arthropathy | 154.97 | 11.09 | 20 | 118894 | 120947 | 64258871 |
Peritonitis bacterial | 153.72 | 11.09 | 130 | 118784 | 8913 | 64370905 |
Hypersensitivity | 152.86 | 11.09 | 86 | 118828 | 196366 | 64183452 |
Hepatitis B reactivation | 149.69 | 11.09 | 100 | 118814 | 4789 | 64375029 |
Hepatic cancer recurrent | 149.50 | 11.09 | 42 | 118872 | 199 | 64379619 |
Off label use | 144.18 | 11.09 | 639 | 118275 | 632167 | 63747651 |
Portal vein thrombosis | 143.06 | 11.09 | 98 | 118816 | 4893 | 64374925 |
Drug eruption | 142.11 | 11.09 | 246 | 118668 | 35890 | 64343928 |
Haemorrhoids | 137.08 | 11.09 | 194 | 118720 | 23807 | 64356011 |
Erythema multiforme | 135.78 | 11.09 | 156 | 118758 | 15545 | 64364273 |
Therapeutic product effect decreased | 132.17 | 11.09 | 26 | 118888 | 115325 | 64264493 |
Oxygen saturation decreased | 131.92 | 11.09 | 20 | 118894 | 107156 | 64272662 |
Condition aggravated | 127.54 | 11.09 | 314 | 118600 | 372112 | 64007706 |
Product use in unapproved indication | 125.37 | 11.09 | 86 | 118828 | 176532 | 64203286 |
Headache | 124.77 | 11.09 | 1507 | 117407 | 527960 | 63851858 |
Viral mutation identified | 123.56 | 11.09 | 77 | 118837 | 3269 | 64376549 |
Pain | 122.33 | 11.09 | 565 | 118349 | 552946 | 63826872 |
Disease progression | 120.70 | 11.09 | 55 | 118859 | 141625 | 64238193 |
Neutropenia | 117.95 | 11.09 | 801 | 118113 | 238823 | 64140995 |
Hepatorenal syndrome | 115.60 | 11.09 | 77 | 118837 | 3669 | 64376149 |
Drug intolerance | 115.26 | 11.09 | 106 | 118808 | 187886 | 64191932 |
Therapeutic product effect incomplete | 113.08 | 11.09 | 26 | 118888 | 103456 | 64276362 |
Product use issue | 112.93 | 11.09 | 70 | 118844 | 151645 | 64228173 |
Blood uric acid increased | 110.19 | 11.09 | 103 | 118811 | 8060 | 64371758 |
COVID-19 | 106.09 | 11.09 | 3 | 118911 | 65137 | 64314681 |
Cardiac failure congestive | 103.22 | 11.09 | 56 | 118858 | 130524 | 64249294 |
Liver transplant rejection | 103.20 | 11.09 | 66 | 118848 | 2933 | 64376885 |
Blood pressure increased | 102.60 | 11.09 | 100 | 118814 | 172452 | 64207366 |
Hand deformity | 101.82 | 11.09 | 3 | 118911 | 62768 | 64317050 |
Pyrexia | 101.77 | 11.09 | 1518 | 117396 | 557126 | 63822692 |
Weight decreased | 98.85 | 11.09 | 880 | 118034 | 284859 | 64094959 |
Weight increased | 98.02 | 11.09 | 151 | 118763 | 213197 | 64166621 |
Nasopharyngitis | 97.75 | 11.09 | 131 | 118783 | 195942 | 64183876 |
Autoimmune hepatitis | 97.14 | 11.09 | 106 | 118808 | 9978 | 64369840 |
Wound | 97.08 | 11.09 | 13 | 118901 | 76464 | 64303354 |
Musculoskeletal stiffness | 94.27 | 11.09 | 55 | 118859 | 123151 | 64256667 |
Portal hypertension | 92.78 | 11.09 | 83 | 118831 | 6136 | 64373682 |
Intentional overdose | 91.74 | 11.09 | 26 | 118888 | 89918 | 64289900 |
Hepatic hydrothorax | 91.49 | 11.09 | 22 | 118892 | 47 | 64379771 |
Flushing | 87.45 | 11.09 | 19 | 118895 | 78629 | 64301189 |
Electrocardiogram QT prolonged | 86.72 | 11.09 | 20 | 118894 | 79428 | 64300390 |
Mood swings | 83.65 | 11.09 | 130 | 118784 | 17338 | 64362480 |
Cutaneous sarcoidosis | 83.59 | 11.09 | 31 | 118883 | 397 | 64379421 |
Basedow's disease | 82.94 | 11.09 | 27 | 118887 | 227 | 64379591 |
Sinusitis | 81.72 | 11.09 | 89 | 118825 | 145839 | 64233979 |
Intentional product misuse | 81.34 | 11.09 | 17 | 118897 | 72278 | 64307540 |
Injection site pain | 79.35 | 11.09 | 54 | 118860 | 111354 | 64268464 |
Depressed mood | 79.18 | 11.09 | 209 | 118705 | 40803 | 64339015 |
Pain in extremity | 78.23 | 11.09 | 291 | 118623 | 302794 | 64077024 |
Anger | 76.57 | 11.09 | 118 | 118796 | 15623 | 64364195 |
Maternal exposure during pregnancy | 75.94 | 11.09 | 41 | 118873 | 95843 | 64283975 |
Hypertension | 75.68 | 11.09 | 236 | 118678 | 259025 | 64120793 |
Blood pressure fluctuation | 73.05 | 11.09 | 6 | 118908 | 51865 | 64327953 |
Systemic lupus erythematosus | 72.81 | 11.09 | 26 | 118888 | 77586 | 64302232 |
Intentional product use issue | 72.34 | 11.09 | 43 | 118871 | 95321 | 64284497 |
Yellow skin | 70.78 | 11.09 | 53 | 118861 | 3046 | 64376772 |
Sarcoidosis | 70.64 | 11.09 | 71 | 118843 | 6075 | 64373743 |
Glomerulonephritis membranoproliferative | 70.36 | 11.09 | 29 | 118885 | 500 | 64379318 |
Child-Pugh-Turcotte score increased | 68.63 | 11.09 | 16 | 118898 | 28 | 64379790 |
Vomiting | 68.38 | 11.09 | 1409 | 117505 | 549708 | 63830110 |
Rash pruritic | 67.41 | 11.09 | 246 | 118668 | 57158 | 64322660 |
Haemolysis | 67.17 | 11.09 | 92 | 118822 | 10947 | 64368871 |
Swelling | 65.63 | 11.09 | 122 | 118792 | 160096 | 64219722 |
Cardiac arrest | 65.18 | 11.09 | 115 | 118799 | 153949 | 64225869 |
Osteoarthritis | 65.15 | 11.09 | 18 | 118896 | 63318 | 64316500 |
Mobility decreased | 64.69 | 11.09 | 39 | 118875 | 85801 | 64294017 |
Infection | 63.86 | 11.09 | 155 | 118759 | 184725 | 64195093 |
Sedation | 63.75 | 11.09 | 3 | 118911 | 41459 | 64338359 |
C-reactive protein increased | 63.68 | 11.09 | 49 | 118865 | 94860 | 64284958 |
Hospitalisation | 62.78 | 11.09 | 30 | 118884 | 75177 | 64304641 |
Anaphylactic reaction | 62.73 | 11.09 | 24 | 118890 | 68640 | 64311178 |
Wheezing | 61.59 | 11.09 | 36 | 118878 | 80543 | 64299275 |
Toxic skin eruption | 61.56 | 11.09 | 120 | 118794 | 19164 | 64360654 |
Urticaria | 61.39 | 11.09 | 111 | 118803 | 147206 | 64232612 |
Chills | 61.10 | 11.09 | 448 | 118466 | 136816 | 64243002 |
Mucosal inflammation | 60.37 | 11.09 | 20 | 118894 | 62564 | 64317254 |
Bilirubin conjugated increased | 58.22 | 11.09 | 58 | 118856 | 4910 | 64374908 |
Blood cholesterol increased | 57.93 | 11.09 | 11 | 118903 | 50055 | 64329763 |
Encephalopathy | 57.59 | 11.09 | 238 | 118676 | 58581 | 64321237 |
Type 1 diabetes mellitus | 56.75 | 11.09 | 61 | 118853 | 5644 | 64374174 |
Gastric varices haemorrhage | 56.72 | 11.09 | 22 | 118892 | 321 | 64379497 |
Renal disorder | 56.26 | 11.09 | 168 | 118746 | 35197 | 64344621 |
Arthralgia | 56.12 | 11.09 | 533 | 118381 | 441727 | 63938091 |
Suicidal ideation | 55.81 | 11.09 | 257 | 118657 | 66285 | 64313533 |
Plasma cell myeloma | 55.77 | 11.09 | 9 | 118905 | 46066 | 64333752 |
Complications of transplanted liver | 55.51 | 11.09 | 22 | 118892 | 341 | 64379477 |
Autoimmune thyroiditis | 54.45 | 11.09 | 48 | 118866 | 3480 | 64376338 |
Hepatitis C virus test | 54.29 | 11.09 | 15 | 118899 | 66 | 64379752 |
Serotonin syndrome | 54.08 | 11.09 | 5 | 118909 | 39277 | 64340541 |
Hepatic enzyme increased | 54.06 | 11.09 | 98 | 118816 | 129845 | 64249973 |
Coronary artery disease | 53.76 | 11.09 | 22 | 118892 | 60411 | 64319407 |
Hyperthyroidism | 53.09 | 11.09 | 109 | 118805 | 18070 | 64361748 |
Psychotic disorder | 52.88 | 11.09 | 162 | 118752 | 34416 | 64345402 |
Disturbance in attention | 52.49 | 11.09 | 181 | 118733 | 40893 | 64338925 |
Hepatic fibrosis | 51.12 | 11.09 | 57 | 118857 | 5495 | 64374323 |
Pulmonary embolism | 51.08 | 11.09 | 122 | 118792 | 146234 | 64233584 |
Hepatitis C virus test positive | 50.17 | 11.09 | 20 | 118894 | 315 | 64379503 |
Depressive symptom | 49.96 | 11.09 | 51 | 118863 | 4445 | 64375373 |
Facial paralysis | 49.92 | 11.09 | 109 | 118805 | 18857 | 64360961 |
Optic ischaemic neuropathy | 49.87 | 11.09 | 40 | 118874 | 2545 | 64377273 |
Therapy non-responder | 49.81 | 11.09 | 247 | 118667 | 65652 | 64314166 |
Myalgia | 49.45 | 11.09 | 478 | 118436 | 158139 | 64221679 |
Neuropathy peripheral | 49.45 | 11.09 | 88 | 118826 | 117437 | 64262381 |
Blood pressure systolic increased | 49.13 | 11.09 | 15 | 118899 | 49438 | 64330380 |
Psoriatic arthropathy | 49.05 | 11.09 | 10 | 118904 | 43271 | 64336547 |
Injury | 48.82 | 11.09 | 21 | 118893 | 55971 | 64323847 |
Alanine aminotransferase increased | 48.39 | 11.09 | 429 | 118485 | 138602 | 64241216 |
Arthritis | 48.15 | 11.09 | 50 | 118864 | 83764 | 64296054 |
Ocular icterus | 48.08 | 11.09 | 53 | 118861 | 5045 | 64374773 |
Malaise | 48.03 | 11.09 | 1010 | 117904 | 395237 | 63984581 |
Hepatitis C RNA | 47.65 | 11.09 | 11 | 118903 | 18 | 64379800 |
Myocardial infarction | 47.60 | 11.09 | 152 | 118762 | 165669 | 64214149 |
Rheumatoid factor positive | 46.65 | 11.09 | 5 | 118909 | 34933 | 64344885 |
Nasal congestion | 46.52 | 11.09 | 26 | 118888 | 59632 | 64320186 |
Alopecia universalis | 46.00 | 11.09 | 16 | 118898 | 168 | 64379650 |
Gait disturbance | 45.87 | 11.09 | 163 | 118751 | 171992 | 64207826 |
Dry mouth | 45.34 | 11.09 | 226 | 118688 | 60192 | 64319626 |
Helicobacter infection | 45.31 | 11.09 | 8 | 118906 | 38354 | 64341464 |
Eczema | 45.22 | 11.09 | 139 | 118775 | 29581 | 64350237 |
Injection site rash | 44.34 | 11.09 | 93 | 118821 | 15649 | 64364169 |
Hypoxia | 43.78 | 11.09 | 59 | 118855 | 88090 | 64291728 |
Acute kidney injury | 43.68 | 11.09 | 575 | 118339 | 448665 | 63931153 |
Duodenal ulcer perforation | 43.66 | 11.09 | 6 | 118908 | 34619 | 64345199 |
Liver transplant failure | 43.51 | 11.09 | 14 | 118900 | 113 | 64379705 |
Retinal detachment | 43.38 | 11.09 | 63 | 118851 | 7913 | 64371905 |
Pneumonia aspiration | 43.18 | 11.09 | 28 | 118886 | 59243 | 64320575 |
Heart rate decreased | 42.94 | 11.09 | 24 | 118890 | 55043 | 64324775 |
Ammonia increased | 42.22 | 11.09 | 58 | 118856 | 6919 | 64372899 |
Asthma | 42.17 | 11.09 | 69 | 118845 | 95156 | 64284662 |
Cardio-respiratory arrest | 42.00 | 11.09 | 73 | 118841 | 98320 | 64281498 |
Aplasia pure red cell | 41.99 | 11.09 | 58 | 118856 | 6956 | 64372862 |
C-reactive protein abnormal | 41.92 | 11.09 | 3 | 118911 | 29044 | 64350774 |
Loss of personal independence in daily activities | 41.88 | 11.09 | 43 | 118871 | 72411 | 64307407 |
Cerebrovascular accident | 41.70 | 11.09 | 123 | 118791 | 137460 | 64242358 |
Bradycardia | 41.68 | 11.09 | 98 | 118816 | 118121 | 64261697 |
Tachycardia | 41.62 | 11.09 | 139 | 118775 | 149440 | 64230378 |
Focal segmental glomerulosclerosis | 41.38 | 11.09 | 38 | 118876 | 2906 | 64376912 |
Atrial fibrillation | 41.06 | 11.09 | 169 | 118745 | 170920 | 64208898 |
Chronic hepatitis C | 40.90 | 11.09 | 20 | 118894 | 523 | 64379295 |
Splenomegaly | 40.38 | 11.09 | 97 | 118817 | 17864 | 64361954 |
Pneumonia | 39.72 | 11.09 | 760 | 118154 | 558816 | 63821002 |
Clostridium difficile infection | 39.66 | 11.09 | 9 | 118905 | 36154 | 64343664 |
Lower respiratory tract infection | 39.66 | 11.09 | 71 | 118843 | 94543 | 64285275 |
Chest discomfort | 39.55 | 11.09 | 98 | 118816 | 116008 | 64263810 |
Lethargy | 39.48 | 11.09 | 249 | 118665 | 72345 | 64307473 |
Discomfort | 39.29 | 11.09 | 55 | 118859 | 80823 | 64298995 |
Angiotensin converting enzyme increased | 38.77 | 11.09 | 13 | 118901 | 121 | 64379697 |
Blood bilirubin unconjugated increased | 38.73 | 11.09 | 23 | 118891 | 894 | 64378924 |
Somnolence | 38.50 | 11.09 | 219 | 118695 | 203426 | 64176392 |
Knee arthroplasty | 38.36 | 11.09 | 3 | 118911 | 26996 | 64352822 |
Product prescribing error | 38.24 | 11.09 | 9 | 118905 | 35260 | 64344558 |
Hepatic neoplasm | 38.06 | 11.09 | 37 | 118877 | 3040 | 64376778 |
Upper respiratory tract infection | 37.92 | 11.09 | 47 | 118867 | 72738 | 64307080 |
Sopor | 37.74 | 11.09 | 5 | 118909 | 29656 | 64350162 |
Pregnancy of partner | 37.70 | 11.09 | 15 | 118899 | 235 | 64379583 |
Impaired healing | 37.14 | 11.09 | 34 | 118880 | 60439 | 64319379 |
Hyperkalaemia | 37.14 | 11.09 | 82 | 118832 | 101047 | 64278771 |
Transfusion | 37.09 | 11.09 | 94 | 118820 | 17900 | 64361918 |
Alcoholism | 36.59 | 11.09 | 38 | 118876 | 3379 | 64376439 |
Angioedema | 36.51 | 11.09 | 36 | 118878 | 61785 | 64318033 |
Osteoporosis | 36.34 | 11.09 | 16 | 118898 | 42064 | 64337754 |
Respiratory arrest | 35.99 | 11.09 | 27 | 118887 | 52958 | 64326860 |
Pain in jaw | 35.98 | 11.09 | 15 | 118899 | 40740 | 64339078 |
Skin disorder | 35.38 | 11.09 | 122 | 118792 | 27558 | 64352260 |
Anorectal disorder | 35.29 | 11.09 | 29 | 118885 | 1910 | 64377908 |
Basal cell carcinoma | 35.20 | 11.09 | 7 | 118907 | 30831 | 64348987 |
Contusion | 35.18 | 11.09 | 101 | 118813 | 113864 | 64265954 |
Overdose | 35.01 | 11.09 | 163 | 118751 | 159403 | 64220415 |
Muscular weakness | 34.97 | 11.09 | 119 | 118795 | 127219 | 64252599 |
Neuroleptic malignant syndrome | 34.90 | 11.09 | 3 | 118911 | 24993 | 64354825 |
Device related infection | 34.86 | 11.09 | 7 | 118907 | 30619 | 64349199 |
Muscle injury | 34.75 | 11.09 | 4 | 118910 | 26433 | 64353385 |
Therapeutic embolisation | 34.43 | 11.09 | 17 | 118897 | 454 | 64379364 |
Irritable bowel syndrome | 34.23 | 11.09 | 13 | 118901 | 37356 | 64342462 |
Coma | 33.88 | 11.09 | 69 | 118845 | 87546 | 64292272 |
Hypoglycaemia | 33.74 | 11.09 | 72 | 118842 | 89820 | 64289998 |
Nephrotic syndrome | 33.58 | 11.09 | 62 | 118852 | 9505 | 64370313 |
Sleep apnoea syndrome | 33.58 | 11.09 | 7 | 118907 | 29825 | 64349993 |
Hyponatraemia | 33.46 | 11.09 | 150 | 118764 | 148189 | 64231629 |
Hepatitis E | 33.44 | 11.09 | 31 | 118883 | 2400 | 64377418 |
Emotional distress | 32.25 | 11.09 | 13 | 118901 | 36025 | 64343793 |
Respiratory depression | 32.23 | 11.09 | 3 | 118911 | 23440 | 64356378 |
Pneumocystis jirovecii pneumonia | 32.12 | 11.09 | 6 | 118908 | 27628 | 64352190 |
Aspartate aminotransferase increased | 32.08 | 11.09 | 350 | 118564 | 119438 | 64260380 |
Acute respiratory failure | 31.96 | 11.09 | 27 | 118887 | 49907 | 64329911 |
Cardiogenic shock | 31.91 | 11.09 | 10 | 118904 | 32417 | 64347401 |
Injection site ulcer | 31.54 | 11.09 | 18 | 118896 | 649 | 64379169 |
Diverticulitis | 31.33 | 11.09 | 16 | 118898 | 38602 | 64341216 |
Hip fracture | 31.25 | 11.09 | 6 | 118908 | 27093 | 64352725 |
General physical health deterioration | 30.97 | 11.09 | 235 | 118679 | 204190 | 64175628 |
Viral load | 30.86 | 11.09 | 8 | 118906 | 26 | 64379792 |
Hypervolaemia | 30.85 | 11.09 | 16 | 118898 | 38269 | 64341549 |
Wrong technique in product usage process | 30.76 | 11.09 | 45 | 118869 | 64929 | 64314889 |
Drug reaction with eosinophilia and systemic symptoms | 30.75 | 11.09 | 188 | 118726 | 54029 | 64325789 |
Exposure via body fluid | 30.53 | 11.09 | 13 | 118901 | 244 | 64379574 |
Glossodynia | 30.44 | 11.09 | 45 | 118869 | 64651 | 64315167 |
Paraesthesia | 30.35 | 11.09 | 136 | 118778 | 134386 | 64245432 |
Respiratory failure | 30.10 | 11.09 | 174 | 118740 | 161009 | 64218809 |
Hepatopulmonary syndrome | 29.97 | 11.09 | 8 | 118906 | 30 | 64379788 |
Labelled drug-drug interaction medication error | 29.86 | 11.09 | 3 | 118911 | 22059 | 64357759 |
Hepatitis C RNA fluctuation | 29.36 | 11.09 | 6 | 118908 | 3 | 64379815 |
Herpes zoster | 29.24 | 11.09 | 64 | 118850 | 79123 | 64300695 |
International normalised ratio increased | 29.22 | 11.09 | 64 | 118850 | 79103 | 64300715 |
Bronchospasm | 29.21 | 11.09 | 3 | 118911 | 21679 | 64358139 |
Testicular germ cell tumour mixed | 29.10 | 11.09 | 7 | 118907 | 15 | 64379803 |
Surgery | 29.05 | 11.09 | 8 | 118906 | 28205 | 64351613 |
Orthostatic hypotension | 29.03 | 11.09 | 26 | 118888 | 46712 | 64333106 |
Throat irritation | 28.94 | 11.09 | 12 | 118902 | 32699 | 64347119 |
Tongue pigmentation | 28.81 | 11.09 | 8 | 118906 | 36 | 64379782 |
Glomerulonephritis | 28.59 | 11.09 | 31 | 118883 | 2897 | 64376921 |
Chronic obstructive pulmonary disease | 28.29 | 11.09 | 55 | 118859 | 70993 | 64308825 |
Palmar-plantar erythrodysaesthesia syndrome | 28.16 | 11.09 | 9 | 118905 | 28810 | 64351008 |
Oedema due to hepatic disease | 27.94 | 11.09 | 7 | 118907 | 19 | 64379799 |
Homicidal ideation | 27.55 | 11.09 | 32 | 118882 | 3225 | 64376593 |
Limb discomfort | 27.43 | 11.09 | 8 | 118906 | 27167 | 64352651 |
Mood altered | 27.42 | 11.09 | 78 | 118836 | 15901 | 64363917 |
Dermatitis | 27.13 | 11.09 | 84 | 118830 | 17945 | 64361873 |
Constipation | 27.09 | 11.09 | 281 | 118633 | 229056 | 64150762 |
Anaphylactic shock | 27.04 | 11.09 | 11 | 118903 | 30317 | 64349501 |
Gastric varices | 26.95 | 11.09 | 15 | 118899 | 515 | 64379303 |
Injection site swelling | 26.91 | 11.09 | 22 | 118892 | 41331 | 64338487 |
Unresponsive to stimuli | 26.82 | 11.09 | 32 | 118882 | 50361 | 64329457 |
Ill-defined disorder | 26.77 | 11.09 | 25 | 118889 | 44027 | 64335791 |
Portal hypertensive gastropathy | 26.67 | 11.09 | 20 | 118894 | 1152 | 64378666 |
Affect lability | 26.36 | 11.09 | 54 | 118860 | 8936 | 64370882 |
Pulmonary oedema | 26.33 | 11.09 | 67 | 118847 | 78607 | 64301211 |
Hip arthroplasty | 26.22 | 11.09 | 4 | 118910 | 21347 | 64358471 |
Device issue | 26.15 | 11.09 | 5 | 118909 | 22643 | 64357175 |
Pericarditis | 26.12 | 11.09 | 47 | 118867 | 62469 | 64317349 |
Rhinorrhoea | 26.04 | 11.09 | 44 | 118870 | 59925 | 64319893 |
Liver disorder | 25.97 | 11.09 | 178 | 118736 | 53173 | 64326645 |
Aplastic anaemia | 25.91 | 11.09 | 70 | 118844 | 13850 | 64365968 |
Sudden hearing loss | 25.86 | 11.09 | 23 | 118891 | 1687 | 64378131 |
Urate nephropathy | 25.78 | 11.09 | 10 | 118904 | 146 | 64379672 |
Hepatic pain | 25.64 | 11.09 | 32 | 118882 | 3476 | 64376342 |
Inflammation | 25.61 | 11.09 | 51 | 118863 | 65249 | 64314569 |
Erythema nodosum | 25.31 | 11.09 | 34 | 118880 | 3970 | 64375848 |
Disease recurrence | 25.16 | 11.09 | 120 | 118794 | 31390 | 64348428 |
Acute stress disorder | 24.95 | 11.09 | 13 | 118901 | 390 | 64379428 |
Photosensitivity reaction | 24.91 | 11.09 | 82 | 118832 | 18091 | 64361727 |
Lymphocyte count decreased | 24.85 | 11.09 | 23 | 118891 | 40676 | 64339142 |
Asterixis | 24.81 | 11.09 | 26 | 118888 | 2337 | 64377481 |
Sudden visual loss | 24.77 | 11.09 | 7 | 118907 | 34 | 64379784 |
Hypothyroidism | 24.68 | 11.09 | 143 | 118771 | 40314 | 64339504 |
Exposure during pregnancy | 24.59 | 11.09 | 68 | 118846 | 77607 | 64302211 |
Bronchitis | 24.49 | 11.09 | 110 | 118804 | 108633 | 64271185 |
Pulmonary tuberculosis | 24.25 | 11.09 | 46 | 118868 | 7198 | 64372620 |
Blood creatinine increased | 24.18 | 11.09 | 368 | 118546 | 135414 | 64244404 |
Inappropriate schedule of product administration | 24.15 | 11.09 | 88 | 118826 | 92198 | 64287620 |
Emotional disorder | 24.07 | 11.09 | 64 | 118850 | 12543 | 64367275 |
Pancreatitis acute | 23.92 | 11.09 | 148 | 118766 | 42707 | 64337111 |
Ocular sarcoidosis | 23.76 | 11.09 | 6 | 118908 | 17 | 64379801 |
Folliculitis | 23.60 | 11.09 | 13 | 118901 | 30064 | 64349754 |
Injection site dermatitis | 23.50 | 11.09 | 6 | 118908 | 18 | 64379800 |
Oral lichen planus | 23.46 | 11.09 | 15 | 118899 | 666 | 64379152 |
Immune thrombocytopenia | 23.42 | 11.09 | 71 | 118843 | 14995 | 64364823 |
Anti-erythropoietin antibody positive | 23.26 | 11.09 | 15 | 118899 | 676 | 64379142 |
Rash papular | 23.26 | 11.09 | 77 | 118837 | 17036 | 64362782 |
Depressed level of consciousness | 23.11 | 11.09 | 75 | 118839 | 81361 | 64298457 |
Abdominal discomfort | 22.94 | 11.09 | 220 | 118694 | 182102 | 64197716 |
Biliary colic | 22.94 | 11.09 | 30 | 118884 | 3414 | 64376404 |
Poisoning | 22.91 | 11.09 | 6 | 118908 | 21873 | 64357945 |
Optic neuropathy | 22.86 | 11.09 | 28 | 118886 | 2983 | 64376835 |
Acute on chronic liver failure | 22.76 | 11.09 | 11 | 118903 | 280 | 64379538 |
Neurotoxicity | 22.76 | 11.09 | 11 | 118903 | 27393 | 64352425 |
Urinary retention | 22.39 | 11.09 | 35 | 118879 | 49166 | 64330652 |
Tendonitis | 22.34 | 11.09 | 5 | 118909 | 20277 | 64359541 |
Thirst | 22.33 | 11.09 | 67 | 118847 | 14070 | 64365748 |
Alpha 1 foetoprotein increased | 22.33 | 11.09 | 15 | 118899 | 725 | 64379093 |
Thrombosis | 22.24 | 11.09 | 62 | 118852 | 70580 | 64309238 |
Genital herpes simplex | 22.07 | 11.09 | 11 | 118903 | 300 | 64379518 |
Mental disorder | 22.06 | 11.09 | 102 | 118812 | 26343 | 64353475 |
Colitis | 22.01 | 11.09 | 47 | 118867 | 58627 | 64321191 |
Intervertebral discitis | 21.76 | 11.09 | 31 | 118883 | 3826 | 64375992 |
Chromaturia | 21.74 | 11.09 | 91 | 118823 | 22520 | 64357298 |
Blood pressure diastolic decreased | 21.73 | 11.09 | 7 | 118907 | 22294 | 64357524 |
Neutropenic sepsis | 21.47 | 11.09 | 8 | 118906 | 23264 | 64356554 |
Acute myeloid leukaemia | 21.36 | 11.09 | 12 | 118902 | 27451 | 64352367 |
Haemorrhoidal haemorrhage | 21.26 | 11.09 | 38 | 118876 | 5681 | 64374137 |
Haematemesis | 21.23 | 11.09 | 154 | 118760 | 46845 | 64332973 |
Hypersplenism | 21.22 | 11.09 | 12 | 118902 | 425 | 64379393 |
Hepatitis virus-associated nephropathy | 21.19 | 11.09 | 4 | 118910 | 0 | 64379818 |
Femur fracture | 21.19 | 11.09 | 19 | 118895 | 34116 | 64345702 |
Injection site eczema | 21.09 | 11.09 | 6 | 118908 | 30 | 64379788 |
Productive cough | 21.06 | 11.09 | 67 | 118847 | 73136 | 64306682 |
Osteonecrosis | 21.02 | 11.09 | 13 | 118901 | 28216 | 64351602 |
Musculoskeletal pain | 20.96 | 11.09 | 78 | 118836 | 81216 | 64298602 |
Breast cancer | 20.92 | 11.09 | 14 | 118900 | 29134 | 64350684 |
Fibromyalgia | 20.88 | 11.09 | 21 | 118893 | 35710 | 64344108 |
Muscle spasticity | 20.76 | 11.09 | 3 | 118911 | 16666 | 64363152 |
Body temperature decreased | 20.65 | 11.09 | 11 | 118903 | 25917 | 64353901 |
Neutralising antibodies positive | 20.61 | 11.09 | 10 | 118904 | 257 | 64379561 |
Fluid retention | 20.53 | 11.09 | 50 | 118864 | 59556 | 64320262 |
Liver function test abnormal | 20.33 | 11.09 | 50 | 118864 | 59351 | 64320467 |
Ejection fraction decreased | 20.32 | 11.09 | 14 | 118900 | 28693 | 64351125 |
Thought blocking | 20.21 | 11.09 | 9 | 118905 | 189 | 64379629 |
Anaemia macrocytic | 20.04 | 11.09 | 32 | 118882 | 4366 | 64375452 |
Extradural abscess | 19.99 | 11.09 | 17 | 118897 | 1174 | 64378644 |
Visual acuity reduced | 19.98 | 11.09 | 101 | 118813 | 27040 | 64352778 |
Bleeding varicose vein | 19.92 | 11.09 | 12 | 118902 | 479 | 64379339 |
Heart rate irregular | 19.90 | 11.09 | 13 | 118901 | 27400 | 64352418 |
Blood disorder | 19.88 | 11.09 | 41 | 118873 | 6816 | 64373002 |
Retinal vein occlusion | 19.86 | 11.09 | 26 | 118888 | 2962 | 64376856 |
Torsade de pointes | 19.70 | 11.09 | 4 | 118910 | 17359 | 64362459 |
Blood bilirubin abnormal | 19.66 | 11.09 | 16 | 118898 | 1039 | 64378779 |
Blood albumin decreased | 19.63 | 11.09 | 84 | 118830 | 20989 | 64358829 |
Blood pressure decreased | 19.53 | 11.09 | 87 | 118827 | 86112 | 64293706 |
Myoclonus | 19.50 | 11.09 | 11 | 118903 | 25107 | 64354711 |
Back pain | 19.50 | 11.09 | 334 | 118580 | 249837 | 64129981 |
Toxic epidermal necrolysis | 19.35 | 11.09 | 24 | 118890 | 37142 | 64342676 |
Status epilepticus | 19.08 | 11.09 | 8 | 118906 | 21655 | 64358163 |
Granulocyte count decreased | 18.98 | 11.09 | 17 | 118897 | 1259 | 64378559 |
Gastrointestinal disorder | 18.87 | 11.09 | 93 | 118821 | 89616 | 64290202 |
Balance disorder | 18.83 | 11.09 | 85 | 118829 | 83841 | 64295977 |
Myelodysplastic syndrome | 18.80 | 11.09 | 14 | 118900 | 27565 | 64352253 |
Feeling cold | 18.78 | 11.09 | 90 | 118824 | 23588 | 64356230 |
Hypocalcaemia | 18.72 | 11.09 | 30 | 118884 | 41723 | 64338095 |
Limb injury | 18.68 | 11.09 | 10 | 118904 | 23495 | 64356323 |
Anticoagulation drug level below therapeutic | 18.57 | 11.09 | 17 | 118897 | 1295 | 64378523 |
Ammonia abnormal | 18.46 | 11.09 | 8 | 118906 | 157 | 64379661 |
Lip swelling | 18.36 | 11.09 | 19 | 118895 | 31888 | 64347930 |
Subarachnoid haemorrhage | 18.35 | 11.09 | 75 | 118839 | 18363 | 64361455 |
Metabolic acidosis | 18.35 | 11.09 | 68 | 118846 | 70890 | 64308928 |
Cardiac disorder | 18.31 | 11.09 | 48 | 118866 | 55768 | 64324050 |
Paranoia | 18.29 | 11.09 | 69 | 118845 | 16283 | 64363535 |
Dystonia | 18.24 | 11.09 | 6 | 118908 | 18859 | 64360959 |
Throat tightness | 18.19 | 11.09 | 10 | 118904 | 23150 | 64356668 |
Chronic hepatic failure | 18.09 | 11.09 | 14 | 118900 | 845 | 64378973 |
Hydrocholecystis | 18.00 | 11.09 | 10 | 118904 | 342 | 64379476 |
Haemophilic arthropathy | 17.99 | 11.09 | 7 | 118907 | 103 | 64379715 |
Alpha 1 foetoprotein abnormal | 17.97 | 11.09 | 6 | 118908 | 55 | 64379763 |
Product quality issue | 17.96 | 11.09 | 105 | 118809 | 29694 | 64350124 |
Fungal infection | 17.96 | 11.09 | 22 | 118892 | 34229 | 64345589 |
Neck pain | 17.93 | 11.09 | 56 | 118858 | 61477 | 64318341 |
Remission not achieved | 17.89 | 11.09 | 10 | 118904 | 346 | 64379472 |
Lung disorder | 17.85 | 11.09 | 55 | 118859 | 60645 | 64319173 |
Eczema asteatotic | 17.78 | 11.09 | 11 | 118903 | 461 | 64379357 |
Hypercalcaemia | 17.75 | 11.09 | 19 | 118895 | 31397 | 64348421 |
Hepatitis cholestatic | 17.70 | 11.09 | 56 | 118858 | 12099 | 64367719 |
Stress | 17.70 | 11.09 | 55 | 118859 | 60479 | 64319339 |
Hypoalbuminaemia | 17.67 | 11.09 | 72 | 118842 | 17602 | 64362216 |
Joint stiffness | 17.61 | 11.09 | 18 | 118896 | 30386 | 64349432 |
Extrapyramidal disorder | 17.58 | 11.09 | 7 | 118907 | 19545 | 64360273 |
Oral mucosal blistering | 17.22 | 11.09 | 33 | 118881 | 5204 | 64374614 |
Pityriasis | 17.16 | 11.09 | 4 | 118910 | 7 | 64379811 |
Clostridium difficile colitis | 17.08 | 11.09 | 15 | 118899 | 27208 | 64352610 |
Peritoneal tuberculosis | 17.07 | 11.09 | 11 | 118903 | 495 | 64379323 |
Dyskinesia | 17.01 | 11.09 | 29 | 118885 | 39359 | 64340459 |
Incorrect route of product administration | 16.97 | 11.09 | 11 | 118903 | 23287 | 64356531 |
Ventricular tachycardia | 16.94 | 11.09 | 23 | 118891 | 34242 | 64345576 |
Cataract | 16.88 | 11.09 | 44 | 118870 | 51218 | 64328600 |
Skin irritation | 16.88 | 11.09 | 46 | 118868 | 9148 | 64370670 |
Lymph node tuberculosis | 16.78 | 11.09 | 14 | 118900 | 942 | 64378876 |
Genital herpes | 16.67 | 11.09 | 19 | 118895 | 1876 | 64377942 |
Pulmonary hypertension | 16.65 | 11.09 | 34 | 118880 | 43105 | 64336713 |
Adverse drug reaction | 16.57 | 11.09 | 37 | 118877 | 45427 | 64334391 |
COVID-19 pneumonia | 16.40 | 11.09 | 5 | 118909 | 16499 | 64363319 |
Infective spondylitis | 16.36 | 11.09 | 10 | 118904 | 410 | 64379408 |
Prostate cancer | 16.36 | 11.09 | 8 | 118906 | 19787 | 64360031 |
Lower gastrointestinal haemorrhage | 16.26 | 11.09 | 3 | 118911 | 13936 | 64365882 |
Bacterascites | 16.20 | 11.09 | 4 | 118910 | 10 | 64379808 |
Gene mutation identification test positive | 16.19 | 11.09 | 8 | 118906 | 214 | 64379604 |
Angina pectoris | 16.18 | 11.09 | 37 | 118877 | 45044 | 64334774 |
Premature delivery | 16.16 | 11.09 | 7 | 118907 | 18582 | 64361236 |
Muscle rigidity | 16.13 | 11.09 | 6 | 118908 | 17467 | 64362351 |
Liver function test increased | 16.12 | 11.09 | 20 | 118894 | 30950 | 64348868 |
Coma hepatic | 16.08 | 11.09 | 14 | 118900 | 998 | 64378820 |
Face oedema | 16.08 | 11.09 | 89 | 118825 | 24672 | 64355146 |
Gingival bleeding | 16.05 | 11.09 | 62 | 118852 | 14792 | 64365026 |
Hepatic lesion | 15.93 | 11.09 | 34 | 118880 | 5790 | 64374028 |
Model for end stage liver disease score | 15.89 | 11.09 | 3 | 118911 | 0 | 64379818 |
Congenital uterine anomaly | 15.89 | 11.09 | 3 | 118911 | 0 | 64379818 |
Vision blurred | 15.77 | 11.09 | 244 | 118670 | 90072 | 64289746 |
Procalcitonin | 15.67 | 11.09 | 4 | 118910 | 12 | 64379806 |
Seizure | 15.66 | 11.09 | 215 | 118699 | 166677 | 64213141 |
Mitochondrial toxicity | 15.63 | 11.09 | 22 | 118892 | 2684 | 64377134 |
Acute myocardial infarction | 15.41 | 11.09 | 71 | 118843 | 69647 | 64310171 |
Decubitus ulcer | 15.35 | 11.09 | 3 | 118911 | 13376 | 64366442 |
Hepatic amoebiasis | 15.20 | 11.09 | 6 | 118908 | 92 | 64379726 |
Transaminases increased | 15.19 | 11.09 | 137 | 118777 | 44457 | 64335361 |
Dyspnoea | 15.11 | 11.09 | 1131 | 117783 | 717543 | 63662275 |
Hair disorder | 15.09 | 11.09 | 13 | 118901 | 914 | 64378904 |
Tubulointerstitial nephritis | 15.03 | 11.09 | 21 | 118893 | 30888 | 64348930 |
Overgrowth fungal | 15.02 | 11.09 | 6 | 118908 | 95 | 64379723 |
Parosmia | 14.96 | 11.09 | 29 | 118885 | 4611 | 64375207 |
Full blood count abnormal | 14.91 | 11.09 | 100 | 118814 | 29657 | 64350161 |
Cheilitis | 14.89 | 11.09 | 29 | 118885 | 4627 | 64375191 |
Procedural pain | 14.88 | 11.09 | 5 | 118909 | 15503 | 64364315 |
Intentional self-injury | 14.87 | 11.09 | 19 | 118895 | 29025 | 64350793 |
Unevaluable event | 14.67 | 11.09 | 46 | 118868 | 50443 | 64329375 |
Injection site haemorrhage | 14.49 | 11.09 | 14 | 118900 | 24264 | 64355554 |
Drug ineffective for unapproved indication | 14.31 | 11.09 | 22 | 118892 | 31111 | 64348707 |
Lacrimation increased | 14.29 | 11.09 | 8 | 118906 | 18338 | 64361480 |
Joint range of motion decreased | 14.27 | 11.09 | 9 | 118905 | 19334 | 64360484 |
Incorrect product administration duration | 14.25 | 11.09 | 45 | 118869 | 9713 | 64370105 |
Hot flush | 14.24 | 11.09 | 41 | 118873 | 46194 | 64333624 |
Injection site mass | 14.24 | 11.09 | 7 | 118907 | 17263 | 64362555 |
Complication associated with device | 14.23 | 11.09 | 5 | 118909 | 15075 | 64364743 |
Serum ferritin increased | 14.20 | 11.09 | 41 | 118873 | 8427 | 64371391 |
Heart rate increased | 14.20 | 11.09 | 115 | 118799 | 98560 | 64281258 |
Immunodeficiency | 14.13 | 11.09 | 6 | 118908 | 16118 | 64363700 |
Cardiac failure | 14.10 | 11.09 | 166 | 118748 | 132207 | 64247611 |
Exposure via partner | 14.06 | 11.09 | 4 | 118910 | 20 | 64379798 |
Hyperlipidaemia | 14.01 | 11.09 | 13 | 118901 | 22963 | 64356855 |
General physical condition abnormal | 13.85 | 11.09 | 31 | 118883 | 5451 | 64374367 |
Granulomatous liver disease | 13.83 | 11.09 | 14 | 118900 | 1208 | 64378610 |
Cerebral arteriovenous malformation haemorrhagic | 13.82 | 11.09 | 3 | 118911 | 3 | 64379815 |
Hashitoxicosis | 13.82 | 11.09 | 3 | 118911 | 3 | 64379815 |
Tinnitus | 13.82 | 11.09 | 109 | 118805 | 34024 | 64345794 |
Left ventricular dysfunction | 13.79 | 11.09 | 7 | 118907 | 16947 | 64362871 |
Pancreas transplant rejection | 13.78 | 11.09 | 8 | 118906 | 298 | 64379520 |
Oesophageal variceal ligation | 13.70 | 11.09 | 6 | 118908 | 121 | 64379697 |
Ankle fracture | 13.67 | 11.09 | 5 | 118909 | 14705 | 64365113 |
Intestinal obstruction | 13.66 | 11.09 | 29 | 118885 | 36257 | 64343561 |
Syncope | 13.65 | 11.09 | 384 | 118530 | 157251 | 64222567 |
VIIIth nerve lesion | 13.60 | 11.09 | 4 | 118910 | 23 | 64379795 |
Injection site warmth | 13.52 | 11.09 | 4 | 118910 | 13458 | 64366360 |
Bone disorder | 13.51 | 11.09 | 7 | 118907 | 16752 | 64363066 |
Haemorrhoids thrombosed | 13.50 | 11.09 | 7 | 118907 | 208 | 64379610 |
Red blood cell sedimentation rate increased | 13.48 | 11.09 | 23 | 118891 | 31212 | 64348606 |
Therapy responder | 13.45 | 11.09 | 9 | 118905 | 432 | 64379386 |
Disability | 13.41 | 11.09 | 3 | 118911 | 12169 | 64367649 |
Chronic hepatitis | 13.40 | 11.09 | 14 | 118900 | 1254 | 64378564 |
Chronic kidney disease | 13.39 | 11.09 | 58 | 118856 | 57861 | 64321957 |
Hepatic mass | 13.37 | 11.09 | 18 | 118896 | 2106 | 64377712 |
Rotator cuff syndrome | 13.30 | 11.09 | 3 | 118911 | 12104 | 64367714 |
Deafness | 13.29 | 11.09 | 68 | 118846 | 18291 | 64361527 |
Hypokinesia | 13.28 | 11.09 | 7 | 118907 | 16589 | 64363229 |
Pneumonitis | 13.19 | 11.09 | 48 | 118866 | 50317 | 64329501 |
Hypomagnesaemia | 13.15 | 11.09 | 31 | 118883 | 37345 | 64342473 |
Sinus congestion | 13.13 | 11.09 | 6 | 118908 | 15433 | 64364385 |
Aspergillus infection | 12.97 | 11.09 | 7 | 118907 | 16372 | 64363446 |
Haematocrit decreased | 12.96 | 11.09 | 156 | 118758 | 54499 | 64325319 |
Intestinal perforation | 12.94 | 11.09 | 6 | 118908 | 15307 | 64364511 |
Injection site bruising | 12.93 | 11.09 | 30 | 118884 | 36343 | 64343475 |
Pulmonary sarcoidosis | 12.88 | 11.09 | 13 | 118901 | 1118 | 64378700 |
Mononeuropathy multiplex | 12.85 | 11.09 | 8 | 118906 | 339 | 64379479 |
Joint injury | 12.83 | 11.09 | 14 | 118900 | 22933 | 64356885 |
Rales | 12.82 | 11.09 | 6 | 118908 | 15223 | 64364595 |
Pemphigoid | 12.79 | 11.09 | 4 | 118910 | 12982 | 64366836 |
Portopulmonary hypertension | 12.78 | 11.09 | 6 | 118908 | 143 | 64379675 |
Hypoaesthesia | 12.76 | 11.09 | 180 | 118734 | 138928 | 64240890 |
Spinal fracture | 12.74 | 11.09 | 6 | 118908 | 15168 | 64364650 |
Accidental exposure to product | 12.73 | 11.09 | 18 | 118896 | 26346 | 64353472 |
Bipolar I disorder | 12.69 | 11.09 | 16 | 118898 | 1755 | 64378063 |
Drug withdrawal syndrome | 12.65 | 11.09 | 24 | 118890 | 31267 | 64348551 |
Exposure via direct contact | 12.65 | 11.09 | 5 | 118909 | 77 | 64379741 |
Hepatocellular injury | 12.60 | 11.09 | 42 | 118872 | 45193 | 64334625 |
Fat intolerance | 12.57 | 11.09 | 4 | 118910 | 31 | 64379787 |
Xerosis | 12.56 | 11.09 | 12 | 118902 | 965 | 64378853 |
Retinal disorder | 12.52 | 11.09 | 16 | 118898 | 1780 | 64378038 |
Hepatorenal failure | 12.49 | 11.09 | 13 | 118901 | 1159 | 64378659 |
Multiple sclerosis | 12.42 | 11.09 | 10 | 118904 | 18931 | 64360887 |
Squamous cell carcinoma | 12.41 | 11.09 | 5 | 118909 | 13864 | 64365954 |
Influenza | 12.37 | 11.09 | 131 | 118783 | 106400 | 64273418 |
Portal vein flow decreased | 12.35 | 11.09 | 4 | 118910 | 33 | 64379785 |
Upper limb fracture | 12.30 | 11.09 | 6 | 118908 | 14860 | 64364958 |
Smooth muscle antibody positive | 12.20 | 11.09 | 6 | 118908 | 159 | 64379659 |
Bursitis | 12.13 | 11.09 | 13 | 118901 | 21472 | 64358346 |
Thyroiditis | 12.11 | 11.09 | 23 | 118891 | 3601 | 64376217 |
Lichen planus | 12.10 | 11.09 | 18 | 118896 | 2310 | 64377508 |
Prurigo | 12.08 | 11.09 | 13 | 118901 | 1204 | 64378614 |
Deafness unilateral | 12.03 | 11.09 | 23 | 118891 | 3619 | 64376199 |
Myopathy | 12.02 | 11.09 | 9 | 118905 | 17671 | 64362147 |
Pulmonary mass | 12.00 | 11.09 | 16 | 118898 | 24000 | 64355818 |
Febrile bone marrow aplasia | 11.95 | 11.09 | 3 | 118911 | 11252 | 64368566 |
Hemiparesis | 11.95 | 11.09 | 23 | 118891 | 29804 | 64350014 |
Acne | 11.92 | 11.09 | 15 | 118899 | 23066 | 64356752 |
Live birth | 11.87 | 11.09 | 3 | 118911 | 11201 | 64368617 |
Gallbladder cancer | 11.86 | 11.09 | 8 | 118906 | 389 | 64379429 |
Acquired porphyria | 11.86 | 11.09 | 4 | 118910 | 38 | 64379780 |
Disseminated intravascular coagulation | 11.85 | 11.09 | 101 | 118813 | 32247 | 64347571 |
Granuloma annulare | 11.84 | 11.09 | 9 | 118905 | 529 | 64379289 |
Posterior reversible encephalopathy syndrome | 11.76 | 11.09 | 15 | 118899 | 22931 | 64356887 |
Oral tuberculosis | 11.75 | 11.09 | 3 | 118911 | 9 | 64379809 |
Renal failure | 11.66 | 11.09 | 427 | 118487 | 181261 | 64198557 |
Papilloedema | 11.60 | 11.09 | 29 | 118885 | 5476 | 64374342 |
Haemochromatosis | 11.59 | 11.09 | 13 | 118901 | 1261 | 64378557 |
Hyperalbuminaemia | 11.59 | 11.09 | 4 | 118910 | 41 | 64379777 |
Antimitochondrial antibody positive | 11.54 | 11.09 | 5 | 118909 | 98 | 64379720 |
Psoriasis | 11.53 | 11.09 | 81 | 118833 | 71622 | 64308196 |
Miosis | 11.52 | 11.09 | 5 | 118909 | 13261 | 64366557 |
Hepatectomy | 11.52 | 11.09 | 6 | 118908 | 180 | 64379638 |
Choroiditis | 11.48 | 11.09 | 12 | 118902 | 1075 | 64378743 |
Cytomegalovirus infection | 11.45 | 11.09 | 33 | 118881 | 37166 | 64342652 |
Aphasia | 11.38 | 11.09 | 38 | 118876 | 40868 | 64338950 |
Hyperhidrosis | 11.33 | 11.09 | 162 | 118752 | 124758 | 64255060 |
Cholelithiasis | 11.28 | 11.09 | 131 | 118783 | 45375 | 64334443 |
Cytomegalovirus viraemia | 11.28 | 11.09 | 3 | 118911 | 10825 | 64368993 |
Gastrointestinal haemorrhage | 11.17 | 11.09 | 174 | 118740 | 132138 | 64247680 |
Deep vein thrombosis | 11.16 | 11.09 | 132 | 118782 | 105050 | 64274768 |
Lung abscess | 11.15 | 11.09 | 22 | 118892 | 3544 | 64376274 |
Ischaemic stroke | 11.11 | 11.09 | 23 | 118891 | 29012 | 64350806 |
Generalised tonic-clonic seizure | 11.10 | 11.09 | 37 | 118877 | 39820 | 64339998 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Exposure via body fluid | 61.35 | 39.91 | 10 | 47 | 3 | 84618 |
Source | Code | Description |
---|---|---|
ATC | J05AP01 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIVIRALS FOR SYSTEMIC USE DIRECT ACTING ANTIVIRALS Antivirals for treatment of HCV infections |
FDA EXT | N0000175459 | Nucleoside Analog |
FDA EPC | N0000175466 | Nucleoside Analog Antiviral |
MeSH PA | D000890 | Anti-Infective Agents |
MeSH PA | D000963 | Antimetabolites |
MeSH PA | D000998 | Antiviral Agents |
MeSH PA | D009676 | Noxae |
CHEBI has role | CHEBI:22587 | antiviral agents |
CHEBI has role | CHEBI:35221 | antimetabolite |
CHEBI has role | CHEBI:35441 | antiinfective agents |
CHEBI has role | CHEBI:59897 | reverse transcriptase inhibitors |
CHEBI has role | CHEBI:149553 | anticoronaviral drug |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Respiratory syncytial virus infection | indication | 55735004 | DOID:1273 |
Chronic hepatitis C | indication | 128302006 | |
Compensated cirrhosis | indication | 371139006 | |
Lassa fever | off-label use | 19065005 | DOID:9537 |
Influenza due to Influenza virus, type B | off-label use | 24662006 | |
Congo-Crimean hemorrhagic fever | off-label use | 43489008 | DOID:12287 |
Hemorrhagic nephroso-nephritis | off-label use | 102455002 | |
Coronavirus infection | off-label use | 186747009 | |
Rift valley fever | off-label use | 402917003 | DOID:1328 |
Influenza due to Influenza A virus | off-label use | 442438000 | |
Chronic obstructive lung disease | contraindication | 13645005 | DOID:3083 |
Cirrhosis of liver | contraindication | 19943007 | DOID:5082 |
Myocardial infarction | contraindication | 22298006 | DOID:5844 |
Constitutional aplastic anemia | contraindication | 28975000 | DOID:1342 |
Sarcoidosis | contraindication | 31541009 | DOID:11335 |
Thalassemia | contraindication | 40108008 | DOID:10241 |
Periodontitis | contraindication | 41565005 | DOID:824 |
Coronary arteriosclerosis | contraindication | 53741008 | DOID:3393 |
Hemolytic anemia | contraindication | 61261009 | DOID:583 |
Interstitial pneumonia | contraindication | 64667001 | |
Pancreatitis | contraindication | 75694006 | DOID:4989 |
Pancytopenia | contraindication | 127034005 | DOID:12450 |
Hb SS disease | contraindication | 127040003 | DOID:10923 |
Asthma | contraindication | 195967001 | DOID:2841 |
Impaired renal function disorder | contraindication | 197663003 | |
Anemia | contraindication | 271737000 | DOID:2355 |
Pregnancy, function | contraindication | 289908002 | |
Bone marrow depression | contraindication | 307762000 | |
Autoimmune hepatitis | contraindication | 408335007 | |
Breastfeeding (mother) | contraindication | 413712001 | |
Myocardial ischemia | contraindication | 414795007 | DOID:3393 |
Pulmonary Infiltrates | contraindication |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 11.65 | acidic |
pKa2 | 12.27 | acidic |
pKa3 | 13.44 | acidic |
pKa4 | 0.35 | Basic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Inosine-5'-monophosphate dehydrogenase 1 | Enzyme | INHIBITOR | IC50 | 6 | IUPHAR | CHEMBL | |||
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 | Enzyme | WOMBAT-PK | |||||||
Cytosolic purine 5'-nucleotidase | Enzyme | WOMBAT-PK | |||||||
Inosine-5'-monophosphate dehydrogenase 2 | Enzyme | INHIBITOR | IC50 | 6 | IUPHAR | ||||
DNA topoisomerase 1 | Enzyme | IC50 | 4.18 | CHEMBL | |||||
Adenosine receptor A1 | GPCR | Ki | 5.13 | CHEMBL | |||||
Adenosine kinase | Kinase | WOMBAT-PK | |||||||
NS5B protein | Enzyme | INHIBITOR | CHEMBL | CHEMBL | |||||
NS5 | Unclassified | EC50 | 4.68 | CHEMBL | |||||
Adenosine receptor A1 | GPCR | Ki | 5.35 | CHEMBL |
ID | Source |
---|---|
4019299 | VUID |
N0000147496 | NUI |
D00423 | KEGG_DRUG |
4019299 | VANDF |
C0035525 | UMLSCUI |
CHEBI:63580 | CHEBI |
RBV | PDB_CHEM_ID |
CHEMBL1643 | ChEMBL_ID |
DB00811 | DRUGBANK_ID |
D012254 | MESH_DESCRIPTOR_UI |
37542 | PUBCHEM_CID |
6842 | IUPHAR_LIGAND_ID |
3543 | INN_ID |
49717AWG6K | UNII |
9344 | RXNORM |
43465 | MMSL |
5421 | MMSL |
d00085 | MMSL |
003018 | NDDF |
35063004 | SNOMEDCT_US |
387188005 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
REBETOL | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0085-1194 | CAPSULE | 200 mg | ORAL | NDA | 31 sections |
REBETOL | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0085-1194 | CAPSULE | 200 mg | ORAL | NDA | 31 sections |
REBETOL | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0085-1318 | LIQUID | 40 mg | ORAL | NDA | 31 sections |
REBETOL | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0085-1318 | LIQUID | 40 mg | ORAL | NDA | 31 sections |
REBETOL | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0085-1351 | CAPSULE | 200 mg | ORAL | NDA | 31 sections |
REBETOL | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0085-1351 | CAPSULE | 200 mg | ORAL | NDA | 31 sections |
REBETOL | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0085-1385 | CAPSULE | 200 mg | ORAL | NDA | 31 sections |
REBETOL | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0085-1385 | CAPSULE | 200 mg | ORAL | NDA | 31 sections |
Virazole | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0187-0007 | POWDER, FOR SOLUTION | 6 g | RESPIRATORY (INHALATION) | NDA | 21 sections |
Ribavirin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 42494-423 | POWDER, FOR SOLUTION | 6 g | RESPIRATORY (INHALATION) | NDA | 23 sections |
Ribavirin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 53808-0781 | CAPSULE | 200 mg | ORAL | ANDA | 21 sections |
Ribavirin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 53808-0782 | TABLET, FILM COATED | 200 mg | ORAL | ANDA | 16 sections |
Ribavirin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 63629-2149 | POWDER, FOR SOLUTION | 6 g | RESPIRATORY (INHALATION) | NDA | 22 sections |
Ribavirin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 63629-2149 | POWDER, FOR SOLUTION | 6 g | RESPIRATORY (INHALATION) | NDA | 22 sections |
Ribavirin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 65841-046 | TABLET, FILM COATED | 200 mg | ORAL | ANDA | 1 sections |
Ribavirin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 65841-129 | TABLET, FILM COATED | 600 mg | ORAL | ANDA | 1 sections |
Ribavirin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 65841-260 | CAPSULE | 200 mg | ORAL | ANDA | 1 sections |
Ribavirin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 65841-603 | TABLET, FILM COATED | 400 mg | ORAL | ANDA | 1 sections |
Ribavirin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 65841-632 | TABLET, FILM COATED | 500 mg | ORAL | ANDA | 1 sections |
Ribavirin | Human Prescription Drug Label | 1 | 65862-207 | TABLET, FILM COATED | 200 mg | ORAL | ANDA | 28 sections |
Ribavirin | Human Prescription Drug Label | 1 | 65862-207 | TABLET, FILM COATED | 200 mg | ORAL | ANDA | 28 sections |
Ribavirin | Human Prescription Drug Label | 1 | 65862-290 | CAPSULE | 200 mg | ORAL | ANDA | 28 sections |
Ribavirin | Human Prescription Drug Label | 1 | 65862-290 | CAPSULE | 200 mg | ORAL | ANDA | 28 sections |
Ribavirin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 68382-046 | TABLET, FILM COATED | 200 mg | ORAL | ANDA | 29 sections |
Ribavirin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 68382-127 | TABLET, FILM COATED | 400 mg | ORAL | ANDA | 29 sections |
Ribavirin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 68382-128 | TABLET, FILM COATED | 500 mg | ORAL | ANDA | 29 sections |
Ribavirin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 68382-129 | TABLET, FILM COATED | 600 mg | ORAL | ANDA | 29 sections |
Ribavirin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 68382-260 | CAPSULE | 200 mg | ORAL | ANDA | 28 sections |
RIBAVIRIN | HUMAN PRESCRIPTION DRUG LABEL | 1 | 68382-395 | POWDER, FOR SOLUTION | 6 g | RESPIRATORY (INHALATION) | ANDA | 19 sections |
RIBAVIRIN | HUMAN PRESCRIPTION DRUG LABEL | 1 | 68475-003 | POWDER, FOR SOLUTION | 6 g | RESPIRATORY (INHALATION) | ANDA | 19 sections |