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ribavirin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| antivirals | 2373 | 36791-04-5 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A nucleoside antimetabolite antiviral agent that blocks nucleic acid synthesis and is used against both RNA and DNA viruses.
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 6 | g | Inhal.solution |
| 1 | g | O |
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Benet LZ, Broccatelli F, Oprea TI |
| S (Water solubility) | 142 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
| EoM (Fraction excreted unchanged in urine) | 17 % | Benet LZ, Broccatelli F, Oprea TI |
| MRTD (Maximum Recommended Therapeutic Daily Dose) | 35.10 µM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
| BA (Bioavailability) | 60 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
| Vd (Volume of distribution) | 14 L/kg | Lombardo F, Berellini G, Obach RS |
| CL (Clearance) | 5.20 mL/min/kg | Lombardo F, Berellini G, Obach RS |
| fu (Fraction unbound in plasma) | 1 % | Lombardo F, Berellini G, Obach RS |
| t_half (Half-life) | 45 hours | Lombardo F, Berellini G, Obach RS |
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| azlogd74 | LogD at pH 7.4 | -1.424 | High | 1 | |
| caco2-efflux | Caco-2 efflux ratio (BA/AB) | 23.714 | High | 1 | |
| caco2-intrinsic-papp | Caco-2 intrinsic apparent permeability | 1.321 | 10^-6 cm/s | High | 1 |
| dh-clint | Dog hepatocyte intrinsic clearance | 1.026 | uL/min/10^6 cells | High | 1 |
| dppb | Dog plasma protein binding (% unbound) | 86.850 | % | High | 1 |
| fcs-ppb | Fetal calf serum protein binding (% unbound) | 92.900 | % | High | 1 |
| herg | hERG pIC50 | 3.432 | pIC50 | High | 1 |
| hh-clint | Human hepatocyte intrinsic clearance | 0.728 | uL/min/10^6 cells | High | 1 |
| hlm-clint | Human liver microsomal intrinsic clearance | 3.258 | uL/min/mg protein | High | 1 |
| hppb | Human plasma protein binding (% unbound) | 75.680 | % | High | 1 |
| kinase-safety-class | ACVR2B,AXL,BRAF,CAMK2D,CDK5,CDK9,DYRK1B,EIF2AK3,ERBB2,GRK2,ITK,MAP2K6,MAP3K21,MAPK7,NTRK1,NTRK2,PDK1,PDK2,PRKDC,TEK | 20 | |||
| kinase-selectivity-class | MAP2K6,PDK1 | 2 | |||
| mdck-mdr1-bcrp-efflux | MDCK-MDR1-BCRP efflux ratio | 0.624 | High | 1 | |
| mdck-mdr1-efflux | MDCK-MDR1 efflux ratio | 4.592 | High | 1 | |
| mh-clint | Mouse hepatocyte intrinsic clearance | 0.294 | High | 1 | |
| mppb | Mouse plasma protein binding (% unbound) | 92.060 | High | 1 | |
| nih-mdck-mdr1-efflux | NIH MDCK-MDR1 efflux ratio | 2.742 | High | 1 | |
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 | |||
| pld-class | Phospholipidosis risk class (1 = positive, 0 = negative) | 0 | High | 1 | |
| pppb | Pig plasma protein binding (% unbound) | 94.800 | % | High | 1 |
| rat-kpuu-brain | Rat brain Kpuu | 0.013 | % | High | 1 |
| rh-clint | Rat hepatocyte intrinsic clearance | 1.660 | uL/min/10^6 cells | High | 1 |
| rh-fuinc | Rat hepatocyte fraction unbound in incubation | 96.880 | % | High | 1 |
| rppb | Rat plasma protein binding (% unbound) | 89.640 | % | High | 1 |
| solubility-dd | Solubility at pH 7.4 in DMSO | 877.001 | uM | High | 1 |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Nov. 21, 2001 | PMDA | Schering-Plough | |
| Dec. 31, 1985 | FDA | VALEANT PHARM INTL |
FDA Adverse Event Reporting System (Female)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Anaemia | 3551.88 | 16.08 | 2296 | 49063 | 350506 | 90226582 |
| Haemoglobin decreased | 1002.81 | 16.08 | 788 | 50571 | 161168 | 90415920 |
| Hepatitis C | 966.42 | 16.08 | 278 | 51081 | 5382 | 90571706 |
| Hepatocellular carcinoma | 857.75 | 16.08 | 212 | 51147 | 2216 | 90574872 |
| Platelet count decreased | 786.65 | 16.08 | 638 | 50721 | 136331 | 90440757 |
| White blood cell count decreased | 750.67 | 16.08 | 676 | 50683 | 166433 | 90410655 |
| Jaundice | 465.83 | 16.08 | 267 | 51092 | 32250 | 90544838 |
| Blood bilirubin increased | 442.99 | 16.08 | 287 | 51072 | 43183 | 90533905 |
| Ascites | 437.55 | 16.08 | 295 | 51064 | 47445 | 90529643 |
| Hepatic failure | 391.83 | 16.08 | 257 | 51102 | 39471 | 90537617 |
| Hyperbilirubinaemia | 390.94 | 16.08 | 180 | 51179 | 13756 | 90563332 |
| Neutrophil count decreased | 363.94 | 16.08 | 311 | 51048 | 71221 | 90505867 |
| Hepatic encephalopathy | 346.50 | 16.08 | 165 | 51194 | 13607 | 90563481 |
| Haemolytic anaemia | 337.26 | 16.08 | 154 | 51205 | 11543 | 90565545 |
| Rash | 318.69 | 16.08 | 1081 | 50278 | 795019 | 89782069 |
| Anal pruritus | 304.39 | 16.08 | 77 | 51282 | 890 | 90576198 |
| Nausea | 297.25 | 16.08 | 1327 | 50032 | 1108989 | 89468099 |
| Leukopenia | 268.91 | 16.08 | 308 | 51051 | 100402 | 90476686 |
| Anorectal discomfort | 260.11 | 16.08 | 88 | 51271 | 2946 | 90574142 |
| Fatigue | 258.30 | 16.08 | 1310 | 50049 | 1152713 | 89424375 |
| Pancytopenia | 228.32 | 16.08 | 310 | 51049 | 119953 | 90457135 |
| Viral load increased | 211.14 | 16.08 | 64 | 51295 | 1492 | 90575596 |
| Thrombocytopenia | 205.19 | 16.08 | 399 | 50960 | 208326 | 90368762 |
| Asthenia | 194.78 | 16.08 | 704 | 50655 | 533047 | 90044041 |
| Influenza like illness | 192.66 | 16.08 | 233 | 51126 | 80378 | 90496710 |
| Pruritus | 185.63 | 16.08 | 700 | 50659 | 540825 | 90036263 |
| Dysgeusia | 179.24 | 16.08 | 183 | 51176 | 52377 | 90524711 |
| Hepatic cirrhosis | 178.21 | 16.08 | 199 | 51160 | 63054 | 90514034 |
| Decreased appetite | 177.68 | 16.08 | 542 | 50817 | 375998 | 90201090 |
| Drug hypersensitivity | 174.84 | 16.08 | 27 | 51332 | 463582 | 90113506 |
| Red blood cell count decreased | 173.94 | 16.08 | 170 | 51189 | 46181 | 90530907 |
| Joint swelling | 169.21 | 16.08 | 39 | 51320 | 503261 | 90073827 |
| Systemic lupus erythematosus | 159.39 | 16.08 | 12 | 51347 | 361884 | 90215204 |
| Depression | 159.22 | 16.08 | 451 | 50908 | 300150 | 90276938 |
| Retinopathy | 156.30 | 16.08 | 63 | 51296 | 3471 | 90573617 |
| Contraindicated product administered | 155.27 | 16.08 | 6 | 51353 | 320133 | 90256955 |
| Arthropathy | 153.50 | 16.08 | 15 | 51344 | 366227 | 90210861 |
| Neutropenia | 149.16 | 16.08 | 367 | 50992 | 224537 | 90352551 |
| Hepatitis C RNA positive | 148.41 | 16.08 | 27 | 51332 | 45 | 90577043 |
| Drug intolerance | 140.21 | 16.08 | 40 | 51319 | 447551 | 90129537 |
| Insomnia | 131.82 | 16.08 | 452 | 50907 | 333022 | 90244066 |
| Vomiting | 131.72 | 16.08 | 829 | 50530 | 787464 | 89789624 |
| Proctalgia | 130.02 | 16.08 | 72 | 51287 | 8126 | 90568962 |
| Therapeutic product effect decreased | 128.73 | 16.08 | 7 | 51352 | 277564 | 90299524 |
| Rheumatoid arthritis | 128.15 | 16.08 | 25 | 51334 | 362589 | 90214499 |
| Product use issue | 122.53 | 16.08 | 20 | 51339 | 329899 | 90247189 |
| Hepatitis C RNA increased | 122.21 | 16.08 | 26 | 51333 | 128 | 90576960 |
| Hyperuricaemia | 114.83 | 16.08 | 62 | 51297 | 6657 | 90570431 |
| Condition aggravated | 112.79 | 16.08 | 103 | 51256 | 595442 | 89981646 |
| Cryoglobulinaemia | 108.55 | 16.08 | 33 | 51326 | 777 | 90576311 |
| Psoriatic arthropathy | 108.28 | 16.08 | 5 | 51354 | 228330 | 90348758 |
| Hypersensitivity | 106.30 | 16.08 | 63 | 51296 | 454614 | 90122474 |
| Pyrexia | 106.08 | 16.08 | 688 | 50671 | 659797 | 89917291 |
| Impaired healing | 105.28 | 16.08 | 7 | 51352 | 234192 | 90342896 |
| Peripheral swelling | 104.20 | 16.08 | 52 | 51307 | 413054 | 90164034 |
| Blood cholesterol increased | 104.00 | 16.08 | 3 | 51356 | 208009 | 90369079 |
| Helicobacter infection | 101.33 | 16.08 | 7 | 51352 | 226843 | 90350245 |
| Pericarditis | 101.14 | 16.08 | 16 | 51343 | 270135 | 90306953 |
| Oesophageal varices haemorrhage | 99.91 | 16.08 | 36 | 51323 | 1456 | 90575632 |
| Off label use | 99.85 | 16.08 | 308 | 51051 | 1101944 | 89475144 |
| Nasopharyngitis | 98.59 | 16.08 | 54 | 51305 | 407050 | 90170038 |
| Hepatic enzyme increased | 97.82 | 16.08 | 41 | 51318 | 360695 | 90216393 |
| Autoimmune hepatitis | 97.24 | 16.08 | 65 | 51294 | 10286 | 90566802 |
| Irritable bowel syndrome | 96.90 | 16.08 | 5 | 51354 | 207443 | 90369645 |
| Musculoskeletal stiffness | 95.61 | 16.08 | 25 | 51334 | 296507 | 90280581 |
| Product use in unapproved indication | 91.50 | 16.08 | 38 | 51321 | 336198 | 90240890 |
| Glossodynia | 91.46 | 16.08 | 34 | 51325 | 321745 | 90255343 |
| Mobility decreased | 91.30 | 16.08 | 16 | 51343 | 250718 | 90326370 |
| Pain | 90.46 | 16.08 | 278 | 51081 | 996063 | 89581025 |
| Chills | 90.20 | 16.08 | 218 | 51141 | 131763 | 90445325 |
| Irritability | 89.95 | 16.08 | 106 | 51253 | 35556 | 90541532 |
| Genotype drug resistance test positive | 89.95 | 16.08 | 25 | 51334 | 424 | 90576664 |
| Virologic failure | 89.32 | 16.08 | 37 | 51322 | 2187 | 90574901 |
| Haemorrhoids | 89.25 | 16.08 | 92 | 51267 | 26610 | 90550478 |
| Hepatitis B reactivation | 89.05 | 16.08 | 44 | 51315 | 3930 | 90573158 |
| Type 2 diabetes mellitus | 88.69 | 16.08 | 7 | 51352 | 203237 | 90373851 |
| Injury | 88.40 | 16.08 | 6 | 51353 | 197343 | 90379745 |
| Dehydration | 86.96 | 16.08 | 275 | 51084 | 194172 | 90382916 |
| Portal vein thrombosis | 86.32 | 16.08 | 40 | 51319 | 3098 | 90573990 |
| Infection | 86.26 | 16.08 | 49 | 51310 | 362045 | 90215043 |
| Porphyria non-acute | 84.94 | 16.08 | 22 | 51337 | 281 | 90576807 |
| Wheezing | 82.84 | 16.08 | 17 | 51342 | 238063 | 90339025 |
| Swelling | 82.24 | 16.08 | 70 | 51289 | 418988 | 90158100 |
| Toxicity to various agents | 80.82 | 16.08 | 31 | 51328 | 287815 | 90289273 |
| Hepatic cancer | 80.52 | 16.08 | 44 | 51315 | 4837 | 90572251 |
| Retinal exudates | 79.13 | 16.08 | 25 | 51334 | 671 | 90576417 |
| COVID-19 | 79.07 | 16.08 | 4 | 51355 | 168839 | 90408249 |
| Osteoarthritis | 76.96 | 16.08 | 10 | 51349 | 195720 | 90381368 |
| Sinusitis | 76.73 | 16.08 | 50 | 51309 | 343038 | 90234050 |
| Discomfort | 76.26 | 16.08 | 30 | 51329 | 274305 | 90302783 |
| Fibromyalgia | 75.45 | 16.08 | 13 | 51346 | 206256 | 90370832 |
| Dry skin | 74.10 | 16.08 | 158 | 51201 | 87915 | 90489173 |
| Vogt-Koyanagi-Harada disease | 73.62 | 16.08 | 21 | 51338 | 393 | 90576695 |
| Liver injury | 71.36 | 16.08 | 7 | 51352 | 170560 | 90406528 |
| Renal impairment | 70.81 | 16.08 | 173 | 51186 | 105248 | 90471840 |
| Varices oesophageal | 70.58 | 16.08 | 37 | 51322 | 3742 | 90573346 |
| Intentional product use issue | 68.54 | 16.08 | 19 | 51340 | 216873 | 90360215 |
| Gastrointestinal disorder | 68.23 | 16.08 | 30 | 51329 | 256657 | 90320431 |
| Abdominal discomfort | 67.36 | 16.08 | 104 | 51255 | 477224 | 90099864 |
| Lower respiratory tract infection | 67.10 | 16.08 | 29 | 51330 | 250630 | 90326458 |
| Cutaneous sarcoidosis | 66.86 | 16.08 | 20 | 51339 | 445 | 90576643 |
| Renal failure | 66.73 | 16.08 | 194 | 51165 | 130813 | 90446275 |
| Hypertension | 65.22 | 16.08 | 99 | 51260 | 457433 | 90119655 |
| Bursitis | 62.02 | 16.08 | 3 | 51356 | 131651 | 90445437 |
| Maternal exposure during pregnancy | 61.51 | 16.08 | 68 | 51291 | 359995 | 90217093 |
| C-reactive protein increased | 60.96 | 16.08 | 14 | 51345 | 181375 | 90395713 |
| Drug reaction with eosinophilia and systemic symptoms | 60.45 | 16.08 | 96 | 51263 | 42662 | 90534426 |
| Urticaria | 60.40 | 16.08 | 53 | 51306 | 312681 | 90264407 |
| Peritonitis bacterial | 59.77 | 16.08 | 37 | 51322 | 5134 | 90571954 |
| Hyperthyroidism | 59.23 | 16.08 | 62 | 51297 | 18248 | 90558840 |
| Weight increased | 59.00 | 16.08 | 91 | 51268 | 417836 | 90159252 |
| Completed suicide | 58.02 | 16.08 | 7 | 51352 | 145051 | 90432037 |
| Therapeutic product effect incomplete | 57.62 | 16.08 | 19 | 51340 | 193877 | 90383211 |
| Liver transplant | 55.95 | 16.08 | 27 | 51332 | 2290 | 90574798 |
| Inflammation | 55.77 | 16.08 | 16 | 51343 | 178576 | 90398512 |
| Ill-defined disorder | 53.41 | 16.08 | 19 | 51340 | 184872 | 90392216 |
| Viral mutation identified | 50.12 | 16.08 | 24 | 51335 | 2001 | 90575087 |
| Rash pruritic | 50.06 | 16.08 | 130 | 51229 | 82084 | 90495004 |
| Hepatorenal syndrome | 49.87 | 16.08 | 24 | 51335 | 2024 | 90575064 |
| Arthralgia | 49.54 | 16.08 | 250 | 51109 | 778272 | 89798816 |
| Sarcoidosis | 49.38 | 16.08 | 44 | 51315 | 10629 | 90566459 |
| Retinal haemorrhage | 48.93 | 16.08 | 34 | 51325 | 5730 | 90571358 |
| Alanine aminotransferase increased | 48.92 | 16.08 | 163 | 51196 | 118175 | 90458913 |
| Exposure via direct contact | 48.74 | 16.08 | 12 | 51347 | 123 | 90576965 |
| Encephalopathy | 48.25 | 16.08 | 91 | 51268 | 46353 | 90530735 |
| Exposure via father | 48.02 | 16.08 | 14 | 51345 | 284 | 90576804 |
| Weight decreased | 46.43 | 16.08 | 371 | 50988 | 379539 | 90197549 |
| Obesity | 45.00 | 16.08 | 4 | 51355 | 105503 | 90471585 |
| Liver transplant rejection | 44.36 | 16.08 | 21 | 51338 | 1707 | 90575381 |
| Exposure via partner | 44.23 | 16.08 | 11 | 51348 | 118 | 90576970 |
| Yellow skin | 43.76 | 16.08 | 24 | 51335 | 2657 | 90574431 |
| Ammonia increased | 43.71 | 16.08 | 30 | 51329 | 4956 | 90572132 |
| Autoimmune thyroiditis | 43.66 | 16.08 | 32 | 51327 | 5861 | 90571227 |
| Child-Pugh-Turcotte score increased | 43.37 | 16.08 | 8 | 51351 | 15 | 90577073 |
| Headache | 43.15 | 16.08 | 707 | 50652 | 862039 | 89715049 |
| Bilirubin conjugated increased | 42.92 | 16.08 | 25 | 51334 | 3105 | 90573983 |
| Aspartate aminotransferase increased | 42.73 | 16.08 | 142 | 51217 | 102795 | 90474293 |
| Myalgia | 41.62 | 16.08 | 203 | 51156 | 174922 | 90402166 |
| Loss of personal independence in daily activities | 41.02 | 16.08 | 13 | 51346 | 136092 | 90440996 |
| Tongue pigmentation | 40.99 | 16.08 | 8 | 51351 | 23 | 90577065 |
| Sciatica | 40.27 | 16.08 | 5 | 51354 | 101377 | 90475711 |
| Toxic skin eruption | 39.96 | 16.08 | 47 | 51312 | 15727 | 90561361 |
| Arthritis | 39.29 | 16.08 | 23 | 51336 | 167292 | 90409796 |
| Haemolysis | 39.20 | 16.08 | 35 | 51324 | 8475 | 90568613 |
| Lung disorder | 39.05 | 16.08 | 18 | 51341 | 149865 | 90427223 |
| Hepatitis cholestatic | 39.02 | 16.08 | 35 | 51324 | 8526 | 90568562 |
| Anorectal disorder | 38.26 | 16.08 | 20 | 51339 | 2011 | 90575077 |
| Face oedema | 38.10 | 16.08 | 56 | 51303 | 23262 | 90553826 |
| Aplasia pure red cell | 38.02 | 16.08 | 28 | 51331 | 5166 | 90571922 |
| Injection site pain | 37.87 | 16.08 | 26 | 51333 | 173673 | 90403415 |
| Exposure via body fluid | 37.86 | 16.08 | 14 | 51345 | 610 | 90576478 |
| Lethargy | 37.57 | 16.08 | 99 | 51260 | 63040 | 90514048 |
| Ocular icterus | 37.40 | 16.08 | 25 | 51334 | 3955 | 90573133 |
| Wound infection | 36.17 | 16.08 | 8 | 51351 | 106394 | 90470694 |
| Syncope | 36.10 | 16.08 | 160 | 51199 | 132503 | 90444585 |
| Aplastic anaemia | 36.07 | 16.08 | 41 | 51318 | 13228 | 90563860 |
| Basedow's disease | 35.56 | 16.08 | 11 | 51348 | 275 | 90576813 |
| Anger | 34.95 | 16.08 | 41 | 51318 | 13679 | 90563409 |
| Mood swings | 34.23 | 16.08 | 50 | 51309 | 20652 | 90556436 |
| Hypoaesthesia | 34.15 | 16.08 | 80 | 51279 | 314130 | 90262958 |
| Hepatic fibrosis | 33.98 | 16.08 | 24 | 51335 | 4151 | 90572937 |
| Hepatitis E | 33.78 | 16.08 | 18 | 51341 | 1881 | 90575207 |
| Fall | 33.34 | 16.08 | 150 | 51209 | 481660 | 90095428 |
| Osteoporosis | 33.33 | 16.08 | 7 | 51352 | 96524 | 90480564 |
| Malaise | 32.95 | 16.08 | 490 | 50869 | 585496 | 89991592 |
| Haematocrit decreased | 32.84 | 16.08 | 73 | 51286 | 41759 | 90535329 |
| Overgrowth fungal | 32.75 | 16.08 | 9 | 51350 | 146 | 90576942 |
| Blister | 32.73 | 16.08 | 59 | 51300 | 254939 | 90322149 |
| Hypothyroidism | 32.32 | 16.08 | 84 | 51275 | 53043 | 90524045 |
| Epistaxis | 32.32 | 16.08 | 114 | 51245 | 85011 | 90492077 |
| Disease progression | 32.12 | 16.08 | 25 | 51334 | 156590 | 90420498 |
| Asthma | 32.01 | 16.08 | 55 | 51304 | 242105 | 90334983 |
| Intentional product misuse | 31.98 | 16.08 | 6 | 51353 | 89598 | 90487490 |
| Liver function test increased | 31.79 | 16.08 | 5 | 51354 | 84850 | 90492238 |
| Angiotensin converting enzyme increased | 31.74 | 16.08 | 8 | 51351 | 91 | 90576997 |
| Live birth | 31.18 | 16.08 | 4 | 51355 | 79103 | 90497985 |
| Hepatic cancer recurrent | 31.18 | 16.08 | 9 | 51350 | 176 | 90576912 |
| Oxygen saturation decreased | 31.11 | 16.08 | 11 | 51348 | 107472 | 90469616 |
| Rash papular | 30.57 | 16.08 | 47 | 51312 | 20308 | 90556780 |
| Splenomegaly | 30.26 | 16.08 | 37 | 51322 | 12887 | 90564201 |
| Muscular weakness | 30.09 | 16.08 | 44 | 51315 | 206622 | 90370466 |
| Lip dry | 29.79 | 16.08 | 10 | 51349 | 100945 | 90476143 |
| Contusion | 29.73 | 16.08 | 61 | 51298 | 251155 | 90325933 |
| Hypersplenism | 28.78 | 16.08 | 10 | 51349 | 363 | 90576725 |
| Erythema multiforme | 28.58 | 16.08 | 35 | 51324 | 12211 | 90564877 |
| Intentional overdose | 28.21 | 16.08 | 9 | 51350 | 93825 | 90483263 |
| Urate nephropathy | 28.08 | 16.08 | 8 | 51351 | 149 | 90576939 |
| Abortion induced | 27.78 | 16.08 | 34 | 51325 | 11854 | 90565234 |
| Pancreas transplant rejection | 27.41 | 16.08 | 8 | 51351 | 163 | 90576925 |
| Liver transplant failure | 27.20 | 16.08 | 6 | 51353 | 36 | 90577052 |
| Disturbance in attention | 27.15 | 16.08 | 73 | 51286 | 47036 | 90530052 |
| Oral mucosal blistering | 27.10 | 16.08 | 26 | 51333 | 6898 | 90570190 |
| Pregnancy of partner | 27.06 | 16.08 | 6 | 51353 | 37 | 90577051 |
| Chromaturia | 27.00 | 16.08 | 43 | 51316 | 19144 | 90557944 |
| Depressive symptom | 26.89 | 16.08 | 23 | 51336 | 5262 | 90571826 |
| Hospitalisation | 26.84 | 16.08 | 20 | 51339 | 128080 | 90449008 |
| Sepsis | 26.70 | 16.08 | 184 | 51175 | 179630 | 90397458 |
| Pain in extremity | 26.18 | 16.08 | 149 | 51210 | 450380 | 90126708 |
| Hepatorenal failure | 25.99 | 16.08 | 11 | 51348 | 686 | 90576402 |
| Inappropriate schedule of product administration | 25.92 | 16.08 | 28 | 51331 | 149905 | 90427183 |
| Transfusion | 25.73 | 16.08 | 40 | 51319 | 17448 | 90559640 |
| Hepatitis C virus test positive | 25.45 | 16.08 | 7 | 51352 | 114 | 90576974 |
| Gait disturbance | 25.45 | 16.08 | 70 | 51289 | 260426 | 90316662 |
| Pathogen resistance | 25.40 | 16.08 | 27 | 51332 | 8088 | 90569000 |
| Erythema nodosum | 25.30 | 16.08 | 23 | 51336 | 5701 | 90571387 |
| Disorientation | 25.06 | 16.08 | 68 | 51291 | 44046 | 90533042 |
| Extradural abscess | 25.02 | 16.08 | 13 | 51346 | 1291 | 90575797 |
| Dermatitis | 24.91 | 16.08 | 45 | 51314 | 22175 | 90554913 |
| Anti-erythropoietin antibody positive | 24.67 | 16.08 | 9 | 51350 | 377 | 90576711 |
| Emotional disorder | 24.48 | 16.08 | 36 | 51323 | 14961 | 90562127 |
| Blood creatinine increased | 24.41 | 16.08 | 118 | 51241 | 101268 | 90475820 |
| Glomerulonephritis | 24.38 | 16.08 | 16 | 51343 | 2454 | 90574634 |
| Alcoholism | 23.69 | 16.08 | 14 | 51345 | 1786 | 90575302 |
| Blood potassium decreased | 23.63 | 16.08 | 70 | 51289 | 47657 | 90529431 |
| General physical health deterioration | 23.10 | 16.08 | 113 | 51246 | 355002 | 90222086 |
| Thyroiditis | 23.07 | 16.08 | 18 | 51341 | 3619 | 90573469 |
| Red blood cell sedimentation rate increased | 22.98 | 16.08 | 9 | 51350 | 82586 | 90494502 |
| Drug ineffective | 22.89 | 16.08 | 604 | 50755 | 1383694 | 89193394 |
| Blood pressure systolic increased | 22.87 | 16.08 | 3 | 51356 | 58342 | 90518746 |
| Paranoia | 22.55 | 16.08 | 32 | 51327 | 12876 | 90564212 |
| Musculoskeletal pain | 22.53 | 16.08 | 39 | 51320 | 171212 | 90405876 |
| Gait inability | 22.50 | 16.08 | 30 | 51329 | 146426 | 90430662 |
| Road traffic accident | 22.29 | 16.08 | 17 | 51342 | 107609 | 90469479 |
| Facial paralysis | 22.12 | 16.08 | 35 | 51324 | 15499 | 90561589 |
| Hypophagia | 22.04 | 16.08 | 57 | 51302 | 35880 | 90541208 |
| Nasal congestion | 21.75 | 16.08 | 10 | 51349 | 83404 | 90493684 |
| Suicidal ideation | 21.56 | 16.08 | 91 | 51268 | 73764 | 90503324 |
| Depressed mood | 21.48 | 16.08 | 70 | 51289 | 50152 | 90526936 |
| Blood albumin decreased | 21.41 | 16.08 | 36 | 51323 | 16767 | 90560321 |
| Full blood count abnormal | 21.38 | 16.08 | 57 | 51302 | 36540 | 90540548 |
| Guillain-Barre syndrome | 21.31 | 16.08 | 19 | 51340 | 4593 | 90572495 |
| Drug abuse | 21.28 | 16.08 | 10 | 51349 | 82337 | 90494751 |
| Rhinocerebral mucormycosis | 21.25 | 16.08 | 10 | 51349 | 802 | 90576286 |
| Night sweats | 21.21 | 16.08 | 25 | 51334 | 128741 | 90448347 |
| Injection site rash | 21.05 | 16.08 | 44 | 51315 | 24129 | 90552959 |
| Type 1 diabetes mellitus | 20.61 | 16.08 | 19 | 51340 | 4793 | 90572295 |
| Complications of transplanted liver | 20.53 | 16.08 | 8 | 51351 | 403 | 90576685 |
| Blood bilirubin unconjugated increased | 20.41 | 16.08 | 8 | 51351 | 409 | 90576679 |
| Paraesthesia | 20.41 | 16.08 | 73 | 51286 | 250253 | 90326835 |
| Autoimmune disorder | 20.32 | 16.08 | 9 | 51350 | 76735 | 90500353 |
| Septic shock | 20.30 | 16.08 | 98 | 51261 | 84062 | 90493026 |
| Paternal drugs affecting foetus | 20.24 | 16.08 | 5 | 51354 | 52 | 90577036 |
| Abortion spontaneous | 20.18 | 16.08 | 72 | 51287 | 53984 | 90523104 |
| Hepatic hydrothorax | 20.16 | 16.08 | 5 | 51354 | 53 | 90577035 |
| Blood pressure fluctuation | 19.83 | 16.08 | 3 | 51356 | 52410 | 90524678 |
| Hepatitis B | 19.66 | 16.08 | 18 | 51341 | 4501 | 90572587 |
| Colitis ulcerative | 19.55 | 16.08 | 5 | 51354 | 60261 | 90516827 |
| Drug eruption | 19.54 | 16.08 | 54 | 51305 | 35353 | 90541735 |
| Vision blurred | 19.52 | 16.08 | 118 | 51241 | 110175 | 90466913 |
| Sleep disorder | 19.50 | 16.08 | 53 | 51306 | 197977 | 90379111 |
| Oral candidiasis | 19.49 | 16.08 | 54 | 51305 | 35401 | 90541687 |
| Miscarriage of partner | 19.43 | 16.08 | 3 | 51356 | 0 | 90577088 |
| Cerebral arteriovenous malformation haemorrhagic | 19.43 | 16.08 | 3 | 51356 | 0 | 90577088 |
| Hepatitis virus-associated nephropathy | 19.43 | 16.08 | 3 | 51356 | 0 | 90577088 |
| Joint stiffness | 19.37 | 16.08 | 10 | 51349 | 78032 | 90499056 |
| VIIIth nerve lesion | 19.28 | 16.08 | 4 | 51355 | 17 | 90577071 |
| Gingival bleeding | 19.08 | 16.08 | 32 | 51327 | 14871 | 90562217 |
| Portal hypertension | 19.06 | 16.08 | 18 | 51341 | 4683 | 90572405 |
| Multiple organ dysfunction syndrome | 19.02 | 16.08 | 83 | 51276 | 68253 | 90508835 |
| Adverse drug reaction | 18.86 | 16.08 | 23 | 51336 | 116678 | 90460410 |
| Gastric varices haemorrhage | 18.82 | 16.08 | 6 | 51353 | 166 | 90576922 |
| Pulmonary fibrosis | 18.66 | 16.08 | 20 | 51339 | 107483 | 90469605 |
| Therapy responder | 18.46 | 16.08 | 7 | 51352 | 327 | 90576761 |
| Excessive dynamic airway collapse | 18.43 | 16.08 | 4 | 51355 | 22 | 90577066 |
| Disease recurrence | 18.43 | 16.08 | 55 | 51304 | 37598 | 90539490 |
| Epilepsy | 18.32 | 16.08 | 12 | 51347 | 82194 | 90494894 |
| Flushing | 18.30 | 16.08 | 14 | 51345 | 88477 | 90488611 |
| Crying | 18.19 | 16.08 | 43 | 51316 | 25602 | 90551486 |
| Hypertrichosis | 18.16 | 16.08 | 11 | 51348 | 1468 | 90575620 |
| Glomerulonephritis membranoproliferative | 18.13 | 16.08 | 7 | 51352 | 344 | 90576744 |
| Retinal disorder | 17.90 | 16.08 | 12 | 51347 | 1907 | 90575181 |
| Bleeding varicose vein | 17.75 | 16.08 | 7 | 51352 | 364 | 90576724 |
| Ocular sarcoidosis | 17.71 | 16.08 | 5 | 51354 | 90 | 90576998 |
| Cholecystitis acute | 17.45 | 16.08 | 24 | 51335 | 9380 | 90567708 |
| Febrile neutropenia | 17.44 | 16.08 | 40 | 51319 | 158309 | 90418779 |
| Psoriasis | 17.37 | 16.08 | 36 | 51323 | 147718 | 90429370 |
| Vertigo | 17.35 | 16.08 | 82 | 51277 | 69729 | 90507359 |
| Maternal exposure before pregnancy | 16.99 | 16.08 | 26 | 51333 | 11187 | 90565901 |
| Congenital tongue anomaly | 16.89 | 16.08 | 3 | 51356 | 4 | 90577084 |
| Retinal detachment | 16.74 | 16.08 | 20 | 51339 | 6802 | 90570286 |
| Prothrombin time prolonged | 16.74 | 16.08 | 24 | 51335 | 9748 | 90567340 |
| Hepatic function abnormal | 16.72 | 16.08 | 61 | 51298 | 46227 | 90530861 |
| Mental disorder | 16.57 | 16.08 | 48 | 51311 | 32270 | 90544818 |
| Visual acuity reduced | 16.33 | 16.08 | 39 | 51320 | 23371 | 90553717 |
| Cheilitis | 16.28 | 16.08 | 17 | 51342 | 4990 | 90572098 |
| Oral pain | 16.24 | 16.08 | 48 | 51311 | 32635 | 90544453 |
| Acute hepatic failure | 16.19 | 16.08 | 38 | 51321 | 22523 | 90554565 |
| Frequent bowel movements | 16.18 | 16.08 | 6 | 51353 | 56929 | 90520159 |
| Hepatitis C virus test | 16.14 | 16.08 | 3 | 51356 | 6 | 90577082 |
| Oedema due to hepatic disease | 16.14 | 16.08 | 3 | 51356 | 6 | 90577082 |
FDA Adverse Event Reporting System (Male)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Anaemia | 2280.48 | 13.59 | 2535 | 67494 | 277743 | 42273563 |
| Hepatitis C | 2107.22 | 13.59 | 745 | 69284 | 9388 | 42541918 |
| Hepatocellular carcinoma | 2066.79 | 13.59 | 696 | 69333 | 7498 | 42543808 |
| Rash | 875.01 | 13.59 | 1599 | 68430 | 275355 | 42275951 |
| Hepatic cirrhosis | 713.11 | 13.59 | 429 | 69600 | 19273 | 42532033 |
| Fatigue | 692.76 | 13.59 | 1912 | 68117 | 433729 | 42117577 |
| Haemoglobin decreased | 581.46 | 13.59 | 888 | 69141 | 131583 | 42419723 |
| Treatment failure | 562.60 | 13.59 | 600 | 69429 | 62024 | 42489282 |
| White blood cell count decreased | 557.94 | 13.59 | 791 | 69238 | 109605 | 42441701 |
| Ascites | 491.37 | 13.59 | 533 | 69496 | 56145 | 42495161 |
| Blood bilirubin increased | 482.28 | 13.59 | 461 | 69568 | 41791 | 42509515 |
| Genotype drug resistance test positive | 462.70 | 13.59 | 141 | 69888 | 1063 | 42550243 |
| Insomnia | 447.36 | 13.59 | 741 | 69288 | 117512 | 42433794 |
| Hepatic encephalopathy | 440.15 | 13.59 | 296 | 69733 | 16146 | 42535160 |
| Pruritus | 429.90 | 13.59 | 953 | 69076 | 187818 | 42363488 |
| Influenza like illness | 426.58 | 13.59 | 380 | 69649 | 31460 | 42519846 |
| Platelet count decreased | 389.41 | 13.59 | 763 | 69266 | 137818 | 42413488 |
| Anorectal discomfort | 372.31 | 13.59 | 140 | 69889 | 2115 | 42549191 |
| Hepatic failure | 359.61 | 13.59 | 375 | 69654 | 37725 | 42513581 |
| Depression | 357.22 | 13.59 | 649 | 69380 | 110714 | 42440592 |
| Anal pruritus | 334.14 | 13.59 | 87 | 69942 | 335 | 42550971 |
| Hyperbilirubinaemia | 320.37 | 13.59 | 268 | 69761 | 20367 | 42530939 |
| Jaundice | 302.56 | 13.59 | 327 | 69702 | 34262 | 42517044 |
| Hepatic cancer | 274.39 | 13.59 | 172 | 69857 | 8308 | 42542998 |
| Liver transplant | 274.05 | 13.59 | 118 | 69911 | 2573 | 42548733 |
| Retinopathy | 252.10 | 13.59 | 106 | 69923 | 2175 | 42549131 |
| Irritability | 244.36 | 13.59 | 265 | 69764 | 27863 | 42523443 |
| Oesophageal varices haemorrhage | 240.98 | 13.59 | 118 | 69911 | 3489 | 42547817 |
| Virologic failure | 229.59 | 13.59 | 118 | 69911 | 3876 | 42547430 |
| Headache | 205.34 | 13.59 | 857 | 69172 | 238512 | 42312794 |
| Toxicity to various agents | 205.18 | 13.59 | 61 | 69968 | 229075 | 42322231 |
| Nausea | 203.24 | 13.59 | 1227 | 68802 | 395572 | 42155734 |
| Viral load increased | 203.08 | 13.59 | 99 | 69930 | 2898 | 42548408 |
| Neutrophil count decreased | 196.01 | 13.59 | 364 | 69665 | 63051 | 42488255 |
| Leukopenia | 187.46 | 13.59 | 393 | 69636 | 74353 | 42476953 |
| Febrile neutropenia | 178.35 | 13.59 | 43 | 69986 | 185660 | 42365646 |
| Death | 175.64 | 13.59 | 317 | 69712 | 470868 | 42080438 |
| Off label use | 171.02 | 13.59 | 513 | 69516 | 637822 | 41913484 |
| Hepatitis C RNA positive | 158.17 | 13.59 | 40 | 69989 | 133 | 42551173 |
| Dysgeusia | 157.72 | 13.59 | 235 | 69794 | 33954 | 42517352 |
| Hepatitis C RNA increased | 153.28 | 13.59 | 44 | 69985 | 262 | 42551044 |
| Malignant neoplasm progression | 151.98 | 13.59 | 6 | 70023 | 108394 | 42442912 |
| Haemolytic anaemia | 141.40 | 13.59 | 134 | 69895 | 11993 | 42539313 |
| Decreased appetite | 137.09 | 13.59 | 654 | 69375 | 192483 | 42358823 |
| Product use in unapproved indication | 135.35 | 13.59 | 67 | 69962 | 184389 | 42366917 |
| Retinal exudates | 134.67 | 13.59 | 51 | 69978 | 786 | 42550520 |
| Peritonitis bacterial | 133.28 | 13.59 | 102 | 69927 | 6813 | 42544493 |
| Disease progression | 125.31 | 13.59 | 40 | 69989 | 143616 | 42407690 |
| Proctalgia | 124.52 | 13.59 | 99 | 69930 | 6994 | 42544312 |
| Haemorrhoids | 124.47 | 13.59 | 147 | 69882 | 16950 | 42534356 |
| Viral mutation identified | 124.22 | 13.59 | 74 | 69955 | 3257 | 42548049 |
| Porphyria non-acute | 120.64 | 13.59 | 41 | 69988 | 453 | 42550853 |
| Hypotension | 119.26 | 13.59 | 149 | 69880 | 257482 | 42293824 |
| Varices oesophageal | 117.75 | 13.59 | 79 | 69950 | 4286 | 42547020 |
| Drug hypersensitivity | 112.65 | 13.59 | 15 | 70014 | 99374 | 42451932 |
| Fall | 108.14 | 13.59 | 136 | 69893 | 234384 | 42316922 |
| Drug abuse | 105.05 | 13.59 | 22 | 70007 | 104749 | 42446557 |
| Thrombocytopenia | 103.05 | 13.59 | 598 | 69431 | 189681 | 42361625 |
| Pancytopenia | 102.54 | 13.59 | 424 | 69605 | 117319 | 42433987 |
| Cryoglobulinaemia | 100.61 | 13.59 | 37 | 69992 | 523 | 42550783 |
| Depressed mood | 99.72 | 13.59 | 155 | 69874 | 23229 | 42528077 |
| Hyperuricaemia | 96.52 | 13.59 | 97 | 69932 | 9327 | 42541979 |
| Hepatic cancer recurrent | 95.54 | 13.59 | 31 | 69998 | 293 | 42551013 |
| Mood swings | 92.52 | 13.59 | 92 | 69937 | 8734 | 42542572 |
| Asthenia | 88.01 | 13.59 | 773 | 69256 | 280020 | 42271286 |
| Condition aggravated | 84.35 | 13.59 | 190 | 69839 | 260564 | 42290742 |
| Hepatorenal syndrome | 82.67 | 13.59 | 54 | 69975 | 2800 | 42548506 |
| Hepatic hydrothorax | 80.59 | 13.59 | 18 | 70011 | 28 | 42551278 |
| Rash pruritic | 77.62 | 13.59 | 171 | 69858 | 33432 | 42517874 |
| Therapeutic product effect incomplete | 77.35 | 13.59 | 12 | 70017 | 70927 | 42480379 |
| Haemolysis | 75.75 | 13.59 | 86 | 69943 | 9503 | 42541803 |
| Hepatitis B reactivation | 74.22 | 13.59 | 61 | 69968 | 4517 | 42546789 |
| Completed suicide | 73.83 | 13.59 | 33 | 69996 | 96432 | 42454874 |
| Oxygen saturation decreased | 72.72 | 13.59 | 10 | 70019 | 64677 | 42486629 |
| Portal vein thrombosis | 72.47 | 13.59 | 60 | 69969 | 4489 | 42546817 |
| Portal hypertension | 69.80 | 13.59 | 60 | 69969 | 4727 | 42546579 |
| Dry skin | 67.98 | 13.59 | 204 | 69825 | 48134 | 42503172 |
| Renal impairment | 67.29 | 13.59 | 358 | 69671 | 109870 | 42441436 |
| Blood pressure increased | 64.77 | 13.59 | 44 | 69985 | 101884 | 42449422 |
| Hepatitis C virus test positive | 64.43 | 13.59 | 23 | 70006 | 297 | 42551009 |
| Hospitalisation | 64.23 | 13.59 | 21 | 70008 | 74309 | 42476997 |
| Intentional product misuse | 64.12 | 13.59 | 12 | 70017 | 61888 | 42489418 |
| Mucosal inflammation | 62.23 | 13.59 | 5 | 70024 | 49369 | 42501937 |
| Acute kidney injury | 62.21 | 13.59 | 352 | 69677 | 366985 | 42184321 |
| Cardiac failure congestive | 61.36 | 13.59 | 32 | 69997 | 85570 | 42465736 |
| Red blood cell count decreased | 60.87 | 13.59 | 153 | 69876 | 32562 | 42518744 |
| General physical health deterioration | 60.42 | 13.59 | 97 | 69932 | 151149 | 42400157 |
| Drug ineffective | 60.25 | 13.59 | 1405 | 68624 | 628792 | 41922514 |
| Anger | 59.31 | 13.59 | 89 | 69940 | 12929 | 42538377 |
| Liver transplant rejection | 54.97 | 13.59 | 40 | 69989 | 2473 | 42548833 |
| Focal segmental glomerulosclerosis | 54.48 | 13.59 | 40 | 69989 | 2508 | 42548798 |
| Vogt-Koyanagi-Harada disease | 54.39 | 13.59 | 18 | 70011 | 182 | 42551124 |
| Encephalopathy | 53.06 | 13.59 | 169 | 69860 | 41164 | 42510142 |
| Suicidal ideation | 52.18 | 13.59 | 186 | 69843 | 47975 | 42503331 |
| Plasma cell myeloma | 51.97 | 13.59 | 8 | 70021 | 47570 | 42503736 |
| Hypertension | 51.45 | 13.59 | 125 | 69904 | 167079 | 42384227 |
| Asthma | 51.43 | 13.59 | 19 | 70010 | 62295 | 42489011 |
| Retinal haemorrhage | 51.19 | 13.59 | 55 | 69974 | 5715 | 42545591 |
| Hepatitis C RNA | 49.42 | 13.59 | 12 | 70017 | 32 | 42551274 |
| Pulmonary embolism | 49.39 | 13.59 | 75 | 69954 | 119537 | 42431769 |
| Gastric varices haemorrhage | 48.34 | 13.59 | 18 | 70011 | 264 | 42551042 |
| Weight increased | 48.26 | 13.59 | 64 | 69965 | 107919 | 42443387 |
| C-reactive protein increased | 48.22 | 13.59 | 22 | 70007 | 63538 | 42487768 |
| Injection site rash | 48.15 | 13.59 | 53 | 69976 | 5659 | 42545647 |
| Weight decreased | 47.30 | 13.59 | 536 | 69493 | 207412 | 42343894 |
| Blood bilirubin unconjugated increased | 47.21 | 13.59 | 23 | 70006 | 672 | 42550634 |
| Bleeding varicose vein | 47.01 | 13.59 | 19 | 70010 | 351 | 42550955 |
| Yellow skin | 45.97 | 13.59 | 35 | 69994 | 2319 | 42548987 |
| Hypoxia | 45.85 | 13.59 | 29 | 70000 | 69757 | 42481549 |
| Atrial fibrillation | 45.64 | 13.59 | 101 | 69928 | 139492 | 42411814 |
| Prostate cancer | 45.50 | 13.59 | 9 | 70020 | 44634 | 42506672 |
| Intentional overdose | 45.41 | 13.59 | 14 | 70015 | 51442 | 42499864 |
| Tachycardia | 45.08 | 13.59 | 60 | 69969 | 101027 | 42450279 |
| Lethargy | 44.87 | 13.59 | 174 | 69855 | 46716 | 42504590 |
| Injection site pain | 43.85 | 13.59 | 20 | 70009 | 57778 | 42493528 |
| Inappropriate schedule of product administration | 42.69 | 13.59 | 57 | 69972 | 95845 | 42455461 |
| Child-Pugh-Turcotte score increased | 42.23 | 13.59 | 10 | 70019 | 23 | 42551283 |
| Viral load | 41.31 | 13.59 | 12 | 70017 | 75 | 42551231 |
| Cardiogenic shock | 41.28 | 13.59 | 5 | 70024 | 35635 | 42515671 |
| Pregnancy of partner | 40.79 | 13.59 | 18 | 70011 | 417 | 42550889 |
| Electrocardiogram QT prolonged | 40.62 | 13.59 | 14 | 70015 | 47931 | 42503375 |
| Heart rate decreased | 40.23 | 13.59 | 6 | 70023 | 36526 | 42514780 |
| Hyperkalaemia | 39.85 | 13.59 | 44 | 69985 | 80414 | 42470892 |
| Ocular icterus | 39.49 | 13.59 | 36 | 69993 | 3065 | 42548241 |
| Anaphylactic reaction | 38.86 | 13.59 | 11 | 70018 | 42732 | 42508574 |
| Coronary artery disease | 38.61 | 13.59 | 20 | 70009 | 53700 | 42497606 |
| Wheezing | 38.48 | 13.59 | 21 | 70008 | 54760 | 42496546 |
| Intentional product use issue | 38.15 | 13.59 | 37 | 69992 | 71796 | 42479510 |
| Foetal exposure during pregnancy | 38.08 | 13.59 | 15 | 70014 | 47296 | 42504010 |
| Peripheral swelling | 37.84 | 13.59 | 56 | 69973 | 90214 | 42461092 |
| Cardiac failure | 37.71 | 13.59 | 74 | 69955 | 106782 | 42444524 |
| Facial paralysis | 37.37 | 13.59 | 71 | 69958 | 12492 | 42538814 |
| Pneumonia aspiration | 36.95 | 13.59 | 18 | 70011 | 50060 | 42501246 |
| Erythema multiforme | 36.89 | 13.59 | 62 | 69967 | 9915 | 42541391 |
| Flushing | 36.63 | 13.59 | 8 | 70021 | 37020 | 42514286 |
| Drug reaction with eosinophilia and systemic symptoms | 36.15 | 13.59 | 151 | 69878 | 41924 | 42509382 |
| Biliary colic | 36.12 | 13.59 | 23 | 70006 | 1141 | 42550165 |
| Bilirubin conjugated increased | 36.10 | 13.59 | 37 | 69992 | 3640 | 42547666 |
| Sedation | 35.98 | 13.59 | 4 | 70025 | 30471 | 42520835 |
| Vomiting | 35.65 | 13.59 | 671 | 69358 | 289052 | 42262254 |
| Glomerulonephritis membranoproliferative | 34.39 | 13.59 | 17 | 70012 | 513 | 42550793 |
| Chronic hepatitis C | 34.12 | 13.59 | 17 | 70012 | 522 | 42550784 |
| Chronic obstructive pulmonary disease | 34.11 | 13.59 | 32 | 69997 | 63082 | 42488224 |
| Acute on chronic liver failure | 33.71 | 13.59 | 11 | 70018 | 106 | 42551200 |
| Cardiac arrest | 33.39 | 13.59 | 82 | 69947 | 109238 | 42442068 |
| Alanine aminotransferase increased | 33.29 | 13.59 | 254 | 69775 | 88152 | 42463154 |
| Affect lability | 33.19 | 13.59 | 37 | 69992 | 4007 | 42547299 |
| Hepatic cytolysis | 33.05 | 13.59 | 3 | 70026 | 26841 | 42524465 |
| Bradycardia | 33.01 | 13.59 | 56 | 69973 | 85428 | 42465878 |
| Blood cholesterol increased | 32.90 | 13.59 | 3 | 70026 | 26738 | 42524568 |
| Hepatic fibrosis | 32.37 | 13.59 | 40 | 69989 | 4832 | 42546474 |
| Therapy non-responder | 32.31 | 13.59 | 173 | 69856 | 53186 | 42498120 |
| Pneumonia | 31.91 | 13.59 | 495 | 69534 | 421654 | 42129652 |
| Neutropenia | 31.86 | 13.59 | 482 | 69547 | 198949 | 42352357 |
| Hepatic pain | 31.71 | 13.59 | 24 | 70005 | 1576 | 42549730 |
| Cardio-respiratory arrest | 31.37 | 13.59 | 30 | 69999 | 58606 | 42492700 |
| Hypersensitivity | 31.21 | 13.59 | 44 | 69985 | 72326 | 42478980 |
| Respiratory failure | 31.19 | 13.59 | 107 | 69922 | 128025 | 42423281 |
| Neuropathy peripheral | 30.63 | 13.59 | 77 | 69952 | 101776 | 42449530 |
| Blood pressure fluctuation | 30.61 | 13.59 | 4 | 70025 | 26904 | 42524402 |
| Disturbance in attention | 30.36 | 13.59 | 113 | 69916 | 29753 | 42521553 |
| Somnolence | 30.33 | 13.59 | 124 | 69905 | 140981 | 42410325 |
| Hyponatraemia | 30.29 | 13.59 | 77 | 69952 | 101385 | 42449921 |
| Drug eruption | 30.20 | 13.59 | 95 | 69934 | 22980 | 42528326 |
| Hepatitis C RNA fluctuation | 30.05 | 13.59 | 6 | 70023 | 3 | 42551303 |
| Mood altered | 29.96 | 13.59 | 59 | 69970 | 10659 | 42540647 |
| Cholelithiasis | 29.54 | 13.59 | 95 | 69934 | 23251 | 42528055 |
| Alpha 1 foetoprotein increased | 29.02 | 13.59 | 17 | 70012 | 725 | 42550581 |
| Wrong technique in product usage process | 29.00 | 13.59 | 17 | 70012 | 42618 | 42508688 |
| Ventricular fibrillation | 28.82 | 13.59 | 7 | 70022 | 30116 | 42521190 |
| Acute stress disorder | 28.72 | 13.59 | 11 | 70018 | 175 | 42551131 |
| Genital herpes simplex | 28.60 | 13.59 | 10 | 70019 | 121 | 42551185 |
| Pain in extremity | 28.37 | 13.59 | 139 | 69890 | 150465 | 42400841 |
| Contraindicated product administered | 28.17 | 13.59 | 4 | 70025 | 25268 | 42526038 |
| Myalgia | 28.17 | 13.59 | 261 | 69768 | 95819 | 42455487 |
| Pneumocystis jirovecii pneumonia | 28.04 | 13.59 | 4 | 70025 | 25177 | 42526129 |
| Hepatitis E | 28.02 | 13.59 | 30 | 69999 | 3104 | 42548202 |
| Psoriatic arthropathy | 27.72 | 13.59 | 4 | 70025 | 24963 | 42526343 |
| Depressed level of consciousness | 27.51 | 13.59 | 23 | 70006 | 47947 | 42503359 |
| Therapeutic product effect decreased | 27.50 | 13.59 | 15 | 70014 | 39135 | 42512171 |
| Ammonia increased | 27.40 | 13.59 | 36 | 69993 | 4623 | 42546683 |
| Anorectal disorder | 27.39 | 13.59 | 20 | 70009 | 1243 | 42550063 |
| Rheumatoid arthritis | 27.37 | 13.59 | 18 | 70011 | 42422 | 42508884 |
| Testicular germ cell tumour mixed | 27.29 | 13.59 | 7 | 70022 | 25 | 42551281 |
| Haematemesis | 27.22 | 13.59 | 110 | 69919 | 30089 | 42521217 |
| Facial paresis | 27.12 | 13.59 | 30 | 69999 | 3220 | 42548086 |
| Musculoskeletal stiffness | 27.08 | 13.59 | 33 | 69996 | 57732 | 42493574 |
| Hepatic neoplasm | 27.05 | 13.59 | 25 | 70004 | 2166 | 42549140 |
| Alopecia universalis | 26.35 | 13.59 | 10 | 70019 | 155 | 42551151 |
| Therapeutic embolisation | 26.13 | 13.59 | 12 | 70017 | 306 | 42551000 |
| Angioedema | 26.09 | 13.59 | 19 | 70010 | 42458 | 42508848 |
| Muscular weakness | 25.99 | 13.59 | 62 | 69967 | 83436 | 42467870 |
| Joint swelling | 25.86 | 13.59 | 45 | 69984 | 67977 | 42483329 |
| Cerebrovascular accident | 25.82 | 13.59 | 78 | 69951 | 97082 | 42454224 |
| Blood pressure systolic increased | 25.79 | 13.59 | 7 | 70022 | 27961 | 42523345 |
| Homicidal ideation | 25.43 | 13.59 | 27 | 70002 | 2767 | 42548539 |
| Drug ineffective for unapproved indication | 25.42 | 13.59 | 23 | 70006 | 46140 | 42505166 |
| Mental disorder | 25.25 | 13.59 | 76 | 69953 | 17953 | 42533353 |
| Haemophilic arthropathy | 25.24 | 13.59 | 11 | 70018 | 247 | 42551059 |
| Psychotic disorder | 25.23 | 13.59 | 105 | 69924 | 29103 | 42522203 |
| Coma hepatic | 25.20 | 13.59 | 13 | 70016 | 430 | 42550876 |
| Exposure via direct contact | 25.08 | 13.59 | 7 | 70022 | 37 | 42551269 |
| Hyperlipidaemia | 24.96 | 13.59 | 3 | 70026 | 21513 | 42529793 |
| Pregnancy | 24.84 | 13.59 | 11 | 70018 | 257 | 42551049 |
| Basedow's disease | 24.78 | 13.59 | 7 | 70022 | 39 | 42551267 |
| Incorrect route of product administration | 24.55 | 13.59 | 5 | 70024 | 24300 | 42527006 |
| Pulmonary oedema | 24.37 | 13.59 | 31 | 69998 | 53241 | 42498065 |
| Skin disorder | 24.27 | 13.59 | 72 | 69957 | 16872 | 42534434 |
| Cardiac disorder | 23.96 | 13.59 | 27 | 70002 | 48905 | 42502401 |
| Lung disorder | 23.95 | 13.59 | 26 | 70003 | 47897 | 42503409 |
| Optic ischaemic neuropathy | 23.83 | 13.59 | 26 | 70003 | 2749 | 42548557 |
| Blood pressure decreased | 23.65 | 13.59 | 37 | 69992 | 58295 | 42493011 |
| Genital herpes | 23.50 | 13.59 | 15 | 70014 | 747 | 42550559 |
| Retinal detachment | 23.39 | 13.59 | 40 | 69989 | 6485 | 42544821 |
| Ammonia abnormal | 23.33 | 13.59 | 8 | 70021 | 91 | 42551215 |
| Upper respiratory tract infection | 23.24 | 13.59 | 21 | 70008 | 42152 | 42509154 |
| Product prescribing error | 23.22 | 13.59 | 7 | 70022 | 26105 | 42525201 |
| Myocardial infarction | 23.03 | 13.59 | 115 | 69914 | 123894 | 42427412 |
| Constipation | 23.01 | 13.59 | 164 | 69865 | 162127 | 42389179 |
| Malaise | 22.91 | 13.59 | 482 | 69547 | 211674 | 42339632 |
| Loss of personal independence in daily activities | 22.78 | 13.59 | 29 | 70000 | 49787 | 42501519 |
| Hepatitis C virus test | 22.49 | 13.59 | 7 | 70022 | 57 | 42551249 |
| Liver transplant failure | 22.02 | 13.59 | 8 | 70021 | 109 | 42551197 |
| Anticoagulation drug level below therapeutic | 21.69 | 13.59 | 16 | 70013 | 1010 | 42550296 |
| Neurotoxicity | 21.66 | 13.59 | 6 | 70023 | 23645 | 42527661 |
| Myelosuppression | 21.29 | 13.59 | 21 | 70008 | 40440 | 42510866 |
| Troponin increased | 21.29 | 13.59 | 3 | 70026 | 19059 | 42532247 |
| Haematuria | 21.28 | 13.59 | 39 | 69990 | 57760 | 42493546 |
| Osteonecrosis of jaw | 21.27 | 13.59 | 3 | 70026 | 19046 | 42532260 |
| Thrombosis | 21.22 | 13.59 | 51 | 69978 | 68460 | 42482846 |
| Photosensitivity reaction | 21.15 | 13.59 | 57 | 69972 | 12645 | 42538661 |
| Stress | 20.99 | 13.59 | 25 | 70004 | 44187 | 42507119 |
| Hepatic lesion | 20.86 | 13.59 | 31 | 69998 | 4463 | 42546843 |
| Pyrexia | 20.70 | 13.59 | 817 | 69212 | 393225 | 42158081 |
| Hypocalcaemia | 20.56 | 13.59 | 12 | 70017 | 30161 | 42521145 |
| Abortion spontaneous | 20.55 | 13.59 | 11 | 70018 | 393 | 42550913 |
| Nasopharyngitis | 20.53 | 13.59 | 70 | 69959 | 83926 | 42467380 |
| Diabetic hyperglycaemic coma | 20.45 | 13.59 | 6 | 70023 | 39 | 42551267 |
| Myelodysplastic syndrome | 20.40 | 13.59 | 6 | 70023 | 22739 | 42528567 |
| Alpha 1 foetoprotein abnormal | 20.16 | 13.59 | 5 | 70024 | 15 | 42551291 |
| Metabolic acidosis | 19.99 | 13.59 | 34 | 69995 | 51824 | 42499482 |
| Thought blocking | 19.98 | 13.59 | 8 | 70021 | 144 | 42551162 |
| Arthropathy | 19.85 | 13.59 | 12 | 70017 | 29585 | 42521721 |
| Syncope | 19.81 | 13.59 | 250 | 69779 | 99156 | 42452150 |
| Hypoglycaemia | 19.79 | 13.59 | 43 | 69986 | 59811 | 42491495 |
| Rhabdomyolysis | 19.76 | 13.59 | 64 | 69965 | 77955 | 42473351 |
| Bronchiectasis | 19.74 | 13.59 | 3 | 70026 | 18016 | 42533290 |
| Anaphylactic shock | 19.69 | 13.59 | 7 | 70022 | 23510 | 42527796 |
| Orthostatic hypotension | 19.67 | 13.59 | 13 | 70016 | 30557 | 42520749 |
| Tubulointerstitial nephritis | 19.52 | 13.59 | 14 | 70015 | 31534 | 42519772 |
| Fat intolerance | 19.42 | 13.59 | 4 | 70025 | 3 | 42551303 |
| Bacterascites | 19.42 | 13.59 | 4 | 70025 | 3 | 42551303 |
| Ventricular tachycardia | 19.17 | 13.59 | 13 | 70016 | 30147 | 42521159 |
| Toxic epidermal necrolysis | 19.16 | 13.59 | 10 | 70019 | 26740 | 42524566 |
| Infection in an immunocompromised host | 19.08 | 13.59 | 15 | 70014 | 1042 | 42550264 |
| Adrenal insufficiency | 18.90 | 13.59 | 4 | 70025 | 18920 | 42532386 |
| Device related infection | 18.84 | 13.59 | 5 | 70024 | 20274 | 42531032 |
| Normal newborn | 18.64 | 13.59 | 10 | 70019 | 359 | 42550947 |
| Liver disorder | 18.48 | 13.59 | 120 | 69909 | 39524 | 42511782 |
| Inflammation | 18.48 | 13.59 | 17 | 70012 | 33830 | 42517476 |
| Mitochondrial toxicity | 18.23 | 13.59 | 22 | 70007 | 2593 | 42548713 |
| Pleural effusion | 18.10 | 13.59 | 90 | 69939 | 97076 | 42454230 |
| Exposure via body fluid | 18.02 | 13.59 | 7 | 70022 | 116 | 42551190 |
| Sarcoidosis | 17.96 | 13.59 | 26 | 70003 | 3656 | 42547650 |
| Productive cough | 17.93 | 13.59 | 36 | 69993 | 51531 | 42499775 |
| Urticaria | 17.88 | 13.59 | 62 | 69967 | 73974 | 42477332 |
| Sudden visual loss | 17.83 | 13.59 | 5 | 70024 | 27 | 42551279 |
| Ejection fraction decreased | 17.78 | 13.59 | 7 | 70022 | 22080 | 42529226 |
| Portal hypertensive gastropathy | 17.78 | 13.59 | 13 | 70016 | 810 | 42550496 |
| Asterixis | 17.56 | 13.59 | 16 | 70013 | 1361 | 42549945 |
| Respiratory distress | 17.46 | 13.59 | 26 | 70003 | 41794 | 42509512 |
| Gastric varices | 17.45 | 13.59 | 12 | 70017 | 678 | 42550628 |
| Acute respiratory failure | 17.38 | 13.59 | 23 | 70006 | 38835 | 42512471 |
| Retinal vein thrombosis | 17.34 | 13.59 | 10 | 70019 | 414 | 42550892 |
| COVID-19 pneumonia | 17.15 | 13.59 | 7 | 70022 | 21606 | 42529700 |
| Diverticulitis | 17.08 | 13.59 | 8 | 70021 | 22765 | 42528541 |
| Drug intolerance | 17.06 | 13.59 | 71 | 69958 | 80353 | 42470953 |
| Borderline personality disorder | 17.02 | 13.59 | 10 | 70019 | 429 | 42550877 |
| Sepsis | 17.01 | 13.59 | 228 | 69801 | 199106 | 42352200 |
| Anti-erythropoietin antibody positive | 16.97 | 13.59 | 13 | 70016 | 869 | 42550437 |
| Oral herpes | 16.97 | 13.59 | 38 | 69991 | 7506 | 42543800 |
| Nightmare | 16.97 | 13.59 | 10 | 70019 | 25002 | 42526304 |
| Clostridium difficile infection | 16.94 | 13.59 | 8 | 70021 | 22651 | 42528655 |
| Urinary retention | 16.90 | 13.59 | 27 | 70002 | 42187 | 42509119 |
| Heart rate irregular | 16.85 | 13.59 | 3 | 70026 | 16047 | 42535259 |
| Haemorrhoidal haemorrhage | 16.80 | 13.59 | 27 | 70002 | 4161 | 42547145 |
| Arthritis | 16.75 | 13.59 | 27 | 70002 | 42038 | 42509268 |
| Emotional disorder | 16.74 | 13.59 | 34 | 69995 | 6280 | 42545026 |
| Hepatitis chronic active | 16.57 | 13.59 | 6 | 70023 | 81 | 42551225 |
| Coma | 16.47 | 13.59 | 40 | 69989 | 53514 | 42497792 |
| Alopecia | 16.43 | 13.59 | 93 | 69936 | 29183 | 42522123 |
| Acute myeloid leukaemia | 16.42 | 13.59 | 8 | 70021 | 22248 | 42529058 |
| Hypophosphataemia | 16.27 | 13.59 | 7 | 70022 | 20938 | 42530368 |
| Viral load undetectable | 16.24 | 13.59 | 3 | 70026 | 0 | 42551306 |
| Labelled drug-drug interaction medication error | 16.17 | 13.59 | 3 | 70026 | 15579 | 42535727 |
| Synovitis | 16.15 | 13.59 | 3 | 70026 | 15564 | 42535742 |
| Cutaneous sarcoidosis | 16.07 | 13.59 | 7 | 70022 | 157 | 42551149 |
| Ear injury | 16.04 | 13.59 | 5 | 70024 | 41 | 42551265 |
| Aplasia pure red cell | 16.01 | 13.59 | 36 | 69993 | 7130 | 42544176 |
| Nasal congestion | 15.89 | 13.59 | 15 | 70014 | 29486 | 42521820 |
| Respiratory arrest | 15.84 | 13.59 | 14 | 70015 | 28410 | 42522896 |
| Dry mouth | 15.80 | 13.59 | 116 | 69913 | 39763 | 42511543 |
| Skin irritation | 15.77 | 13.59 | 37 | 69992 | 7537 | 42543769 |
| Sleep apnoea syndrome | 15.59 | 13.59 | 8 | 70021 | 21600 | 42529706 |
| Accidental exposure to product | 15.55 | 13.59 | 7 | 70022 | 20386 | 42530920 |
| Mouth ulceration | 15.53 | 13.59 | 57 | 69972 | 14906 | 42536400 |
| Gallbladder cancer | 15.25 | 13.59 | 8 | 70021 | 274 | 42551032 |
| Oesophageal variceal ligation | 15.25 | 13.59 | 6 | 70023 | 103 | 42551203 |
| Tongue ulceration | 15.20 | 13.59 | 15 | 70014 | 1410 | 42549896 |
| Lymphocyte count decreased | 15.14 | 13.59 | 14 | 70015 | 27795 | 42523511 |
| Photophobia | 15.12 | 13.59 | 38 | 69991 | 8081 | 42543225 |
| Therapy responder | 15.08 | 13.59 | 7 | 70022 | 183 | 42551123 |
| Deafness congenital | 15.04 | 13.59 | 6 | 70023 | 107 | 42551199 |
| Mobility decreased | 14.69 | 13.59 | 22 | 70007 | 35284 | 42516022 |
| Neutropenic sepsis | 14.69 | 13.59 | 4 | 70025 | 15942 | 42535364 |
| Fungal infection | 14.68 | 13.59 | 7 | 70022 | 19715 | 42531591 |
| Pneumonitis | 14.61 | 13.59 | 29 | 70000 | 41689 | 42509617 |
| Oral lichen planus | 14.54 | 13.59 | 7 | 70022 | 199 | 42551107 |
| Feeling abnormal | 14.54 | 13.59 | 177 | 69852 | 69609 | 42481697 |
| Aspergillus infection | 14.53 | 13.59 | 4 | 70025 | 15833 | 42535473 |
| Body temperature decreased | 14.49 | 13.59 | 3 | 70026 | 14410 | 42536896 |
| Chemical burn of skin | 14.36 | 13.59 | 4 | 70025 | 21 | 42551285 |
| Product use issue | 14.34 | 13.59 | 71 | 69958 | 76680 | 42474626 |
| Dysphagia | 14.33 | 13.59 | 66 | 69963 | 72653 | 42478653 |
| Neutralising antibodies positive | 14.32 | 13.59 | 6 | 70023 | 122 | 42551184 |
| Blood uric acid increased | 14.30 | 13.59 | 57 | 69972 | 15490 | 42535816 |
| Chronic hepatitis | 14.26 | 13.59 | 11 | 70018 | 743 | 42550563 |
| Tachypnoea | 14.22 | 13.59 | 9 | 70020 | 21653 | 42529653 |
| Fibrosis | 14.21 | 13.59 | 21 | 70008 | 3009 | 42548297 |
| Basal cell carcinoma | 14.18 | 13.59 | 10 | 70019 | 22723 | 42528583 |
| Transaminases decreased | 14.16 | 13.59 | 3 | 70026 | 3 | 42551303 |
| Delusional disorder, erotomanic type | 14.16 | 13.59 | 3 | 70026 | 3 | 42551303 |
| Back pain | 14.04 | 13.59 | 157 | 69872 | 141619 | 42409687 |
| Suspected transmission of an infectious agent via product | 13.99 | 13.59 | 12 | 70017 | 942 | 42550364 |
| Injection site erythema | 13.98 | 13.59 | 68 | 69961 | 20127 | 42531179 |
| Hepatic amoebiasis | 13.98 | 13.59 | 5 | 70024 | 65 | 42551241 |
| Gene mutation identification test positive | 13.87 | 13.59 | 7 | 70022 | 221 | 42551085 |
| Pulmonary tuberculosis | 13.85 | 13.59 | 29 | 70000 | 5472 | 42545834 |
| Seizure | 13.79 | 13.59 | 129 | 69900 | 120432 | 42430874 |
| Hypomagnesaemia | 13.64 | 13.59 | 16 | 70013 | 28472 | 42522834 |
| Therapy partial responder | 13.59 | 13.59 | 8 | 70021 | 20013 | 42531293 |
FDA Adverse Event Reporting System (Geriatric)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Anaemia | 5044.09 | 12.97 | 4043 | 95002 | 543043 | 109947211 |
| Hepatitis C | 2848.83 | 12.97 | 852 | 98193 | 11721 | 110478533 |
| Hepatocellular carcinoma | 2833.56 | 12.97 | 804 | 98241 | 9076 | 110481178 |
| Haemoglobin decreased | 1349.83 | 12.97 | 1371 | 97674 | 247356 | 110242898 |
| White blood cell count decreased | 1133.68 | 12.97 | 1203 | 97842 | 228187 | 110262067 |
| Platelet count decreased | 1079.79 | 12.97 | 1175 | 97870 | 229268 | 110260986 |
| Ascites | 972.00 | 12.97 | 744 | 98301 | 92064 | 110398190 |
| Blood bilirubin increased | 886.71 | 12.97 | 650 | 98395 | 75322 | 110414932 |
| Hyperbilirubinaemia | 750.94 | 12.97 | 419 | 98626 | 30252 | 110460002 |
| Hepatic encephalopathy | 741.26 | 12.97 | 404 | 98641 | 27852 | 110462402 |
| Jaundice | 737.14 | 12.97 | 527 | 98518 | 58709 | 110431545 |
| Fatigue | 730.83 | 12.97 | 2563 | 96482 | 1213395 | 109276859 |
| Hepatic failure | 701.87 | 12.97 | 543 | 98502 | 68196 | 110422058 |
| Rash | 699.69 | 12.97 | 1955 | 97090 | 819009 | 109671245 |
| Hepatic cirrhosis | 672.64 | 12.97 | 526 | 98519 | 67100 | 110423154 |
| Neutrophil count decreased | 585.39 | 12.97 | 628 | 98417 | 120313 | 110369941 |
| Insomnia | 470.41 | 12.97 | 1013 | 98032 | 359577 | 110130677 |
| Leukopenia | 463.04 | 12.97 | 617 | 98428 | 148174 | 110342080 |
| Genotype drug resistance test positive | 460.28 | 12.97 | 127 | 98918 | 1279 | 110488975 |
| Anal pruritus | 446.51 | 12.97 | 117 | 98928 | 950 | 110489304 |
| Influenza like illness | 438.12 | 12.97 | 465 | 98580 | 87947 | 110402307 |
| Pruritus | 435.36 | 12.97 | 1324 | 97721 | 580236 | 109910018 |
| Anorectal discomfort | 394.57 | 12.97 | 146 | 98899 | 3980 | 110486274 |
| Haemolytic anaemia | 388.48 | 12.97 | 239 | 98806 | 20681 | 110469573 |
| Retinopathy | 388.11 | 12.97 | 147 | 98898 | 4282 | 110485972 |
| Oesophageal varices haemorrhage | 372.37 | 12.97 | 147 | 98898 | 4798 | 110485456 |
| Depression | 362.64 | 12.97 | 846 | 98199 | 316489 | 110173765 |
| Hepatic cancer | 362.18 | 12.97 | 184 | 98861 | 10972 | 110479282 |
| Thrombocytopenia | 334.92 | 12.97 | 870 | 98175 | 348015 | 110142239 |
| Pancytopenia | 330.01 | 12.97 | 637 | 98408 | 208976 | 110281278 |
| Infusion related reaction | 324.75 | 12.97 | 3 | 99042 | 381159 | 110109095 |
| Irritability | 317.49 | 12.97 | 295 | 98750 | 47514 | 110442740 |
| Nausea | 316.28 | 12.97 | 2036 | 97009 | 1233654 | 109256600 |
| Drug hypersensitivity | 304.49 | 12.97 | 28 | 99017 | 454062 | 110036192 |
| Viral load increased | 298.80 | 12.97 | 113 | 98932 | 3277 | 110486977 |
| Virologic failure | 293.52 | 12.97 | 124 | 98921 | 4828 | 110485426 |
| Liver transplant | 289.07 | 12.97 | 120 | 98925 | 4469 | 110485785 |
| Decreased appetite | 287.66 | 12.97 | 1008 | 98037 | 474838 | 110015416 |
| Hepatitis C RNA positive | 280.81 | 12.97 | 61 | 98984 | 191 | 110490063 |
| Hyperuricaemia | 234.70 | 12.97 | 152 | 98893 | 14379 | 110475875 |
| Joint swelling | 221.99 | 12.97 | 61 | 98984 | 442784 | 110047470 |
| Synovitis | 221.30 | 12.97 | 5 | 99040 | 274087 | 110216167 |
| Dysgeusia | 220.25 | 12.97 | 292 | 98753 | 69693 | 110420561 |
| Toxicity to various agents | 218.09 | 12.97 | 79 | 98966 | 480476 | 110009778 |
| Renal impairment | 208.01 | 12.97 | 496 | 98549 | 187949 | 110302305 |
| Hepatitis C RNA increased | 207.31 | 12.97 | 53 | 98992 | 386 | 110489868 |
| Arthropathy | 205.99 | 12.97 | 13 | 99032 | 287509 | 110202745 |
| Asthenia | 204.31 | 12.97 | 1181 | 97864 | 687818 | 109802436 |
| Proctalgia | 200.61 | 12.97 | 133 | 98912 | 13089 | 110477165 |
| Varices oesophageal | 197.05 | 12.97 | 106 | 98939 | 7109 | 110483145 |
| COVID-19 | 195.80 | 12.97 | 5 | 99040 | 245055 | 110245199 |
| Peritonitis bacterial | 194.68 | 12.97 | 120 | 98925 | 10413 | 110479841 |
| Contraindicated product administered | 191.38 | 12.97 | 7 | 99038 | 248260 | 110241994 |
| Porphyria non-acute | 187.47 | 12.97 | 55 | 98990 | 702 | 110489552 |
| Cryoglobulinaemia | 186.63 | 12.97 | 62 | 98983 | 1217 | 110489037 |
| Off label use | 182.77 | 12.97 | 710 | 98335 | 1499475 | 108990779 |
| Hepatitis B reactivation | 177.01 | 12.97 | 100 | 98945 | 7384 | 110482870 |
| Condition aggravated | 173.89 | 12.97 | 243 | 98802 | 734593 | 109755661 |
| Hypersensitivity | 172.40 | 12.97 | 73 | 98972 | 403925 | 110086329 |
| Retinal exudates | 170.57 | 12.97 | 58 | 98987 | 1226 | 110489028 |
| Viral mutation identified | 170.54 | 12.97 | 82 | 98963 | 4337 | 110485917 |
| Portal vein thrombosis | 168.81 | 12.97 | 95 | 98950 | 6963 | 110483291 |
| Rheumatoid arthritis | 166.46 | 12.97 | 33 | 99012 | 299580 | 110190674 |
| Haemorrhoids | 164.98 | 12.97 | 181 | 98864 | 35491 | 110454763 |
| Systemic lupus erythematosus | 164.33 | 12.97 | 18 | 99027 | 254320 | 110235934 |
| Wound | 163.82 | 12.97 | 12 | 99033 | 234425 | 110255829 |
| Product use in unapproved indication | 162.34 | 12.97 | 100 | 98945 | 447277 | 110042977 |
| Neutropenia | 157.69 | 12.97 | 709 | 98336 | 373911 | 110116343 |
| Drug intolerance | 155.82 | 12.97 | 85 | 98960 | 406427 | 110083827 |
| Peripheral swelling | 149.81 | 12.97 | 88 | 98957 | 403946 | 110086308 |
| Musculoskeletal stiffness | 148.93 | 12.97 | 34 | 99011 | 279788 | 110210466 |
| Therapeutic product effect decreased | 148.79 | 12.97 | 21 | 99024 | 244295 | 110245959 |
| Blood cholesterol increased | 146.74 | 12.97 | 4 | 99041 | 184781 | 110305473 |
| Psoriatic arthropathy | 143.63 | 12.97 | 8 | 99037 | 196753 | 110293501 |
| Treatment failure | 143.43 | 12.97 | 559 | 98486 | 276675 | 110213579 |
| Hepatic cancer recurrent | 141.45 | 12.97 | 37 | 99008 | 298 | 110489956 |
| Red blood cell count decreased | 139.24 | 12.97 | 228 | 98817 | 65695 | 110424559 |
| Wheezing | 137.87 | 12.97 | 30 | 99015 | 255200 | 110235054 |
| Pain | 136.12 | 12.97 | 422 | 98623 | 954533 | 109535721 |
| Hepatorenal syndrome | 135.31 | 12.97 | 71 | 98974 | 4526 | 110485728 |
| Helicobacter infection | 133.98 | 12.97 | 7 | 99038 | 181870 | 110308384 |
| Dry skin | 133.76 | 12.97 | 297 | 98748 | 107356 | 110382898 |
| Duodenal ulcer perforation | 133.60 | 12.97 | 6 | 99039 | 177694 | 110312560 |
| Malignant neoplasm progression | 127.71 | 12.97 | 7 | 99038 | 174560 | 110315694 |
| Headache | 124.89 | 12.97 | 1272 | 97773 | 881105 | 109609149 |
| Fall | 124.17 | 12.97 | 219 | 98826 | 603263 | 109886991 |
| Vogt-Koyanagi-Harada disease | 123.39 | 12.97 | 38 | 99007 | 578 | 110489676 |
| Nasopharyngitis | 122.36 | 12.97 | 104 | 98941 | 394257 | 110095997 |
| Weight increased | 120.32 | 12.97 | 119 | 98926 | 419525 | 110070729 |
| Completed suicide | 118.38 | 12.97 | 35 | 99010 | 242346 | 110247908 |
| Mobility decreased | 118.32 | 12.97 | 33 | 99012 | 237389 | 110252865 |
| Therapeutic product effect incomplete | 117.48 | 12.97 | 28 | 99017 | 223777 | 110266477 |
| Maternal exposure during pregnancy | 117.06 | 12.97 | 41 | 99004 | 254842 | 110235412 |
| Fibromyalgia | 113.21 | 12.97 | 11 | 99034 | 170898 | 110319356 |
| Folliculitis | 113.16 | 12.97 | 10 | 99035 | 167643 | 110322611 |
| Irritable bowel syndrome | 113.03 | 12.97 | 9 | 99036 | 164206 | 110326048 |
| Liver transplant rejection | 111.04 | 12.97 | 59 | 98986 | 3859 | 110486395 |
| Osteoarthritis | 110.48 | 12.97 | 16 | 99029 | 182607 | 110307647 |
| Febrile neutropenia | 109.14 | 12.97 | 75 | 98970 | 316692 | 110173562 |
| C-reactive protein increased | 109.13 | 12.97 | 30 | 99015 | 217889 | 110272365 |
| Injury | 108.48 | 12.97 | 15 | 99030 | 177250 | 110313004 |
| Swelling | 105.95 | 12.97 | 95 | 98950 | 350946 | 110139308 |
| Hypertension | 105.89 | 12.97 | 184 | 98861 | 509900 | 109980354 |
| Retinal haemorrhage | 105.57 | 12.97 | 79 | 98966 | 9422 | 110480832 |
| Depressed mood | 103.22 | 12.97 | 191 | 98854 | 60618 | 110429636 |
| C-reactive protein abnormal | 102.25 | 12.97 | 3 | 99042 | 129692 | 110360562 |
| Product use issue | 101.91 | 12.97 | 78 | 98967 | 311617 | 110178637 |
| Sinusitis | 101.21 | 12.97 | 71 | 98974 | 296617 | 110193637 |
| Intentional product use issue | 100.66 | 12.97 | 48 | 98997 | 247858 | 110242396 |
| Rheumatoid factor positive | 100.43 | 12.97 | 4 | 99041 | 131636 | 110358618 |
| Encephalopathy | 98.86 | 12.97 | 222 | 98823 | 80833 | 110409421 |
| Hepatic hydrothorax | 96.70 | 12.97 | 22 | 99023 | 90 | 110490164 |
| Pericarditis | 95.98 | 12.97 | 38 | 99007 | 219076 | 110271178 |
| Lethargy | 94.34 | 12.97 | 238 | 98807 | 93338 | 110396916 |
| Urticaria | 94.18 | 12.97 | 88 | 98957 | 318769 | 110171485 |
| Portal hypertension | 94.15 | 12.97 | 71 | 98974 | 8566 | 110481688 |
| Glossodynia | 93.22 | 12.97 | 41 | 99004 | 221963 | 110268291 |
| Hepatic enzyme increased | 93.10 | 12.97 | 90 | 98955 | 320802 | 110169452 |
| Alanine aminotransferase increased | 92.90 | 12.97 | 368 | 98677 | 183405 | 110306849 |
| Mood swings | 92.30 | 12.97 | 108 | 98937 | 22704 | 110467550 |
| Pyrexia | 92.11 | 12.97 | 1217 | 97828 | 897048 | 109593206 |
| Impaired healing | 89.70 | 12.97 | 32 | 99013 | 196685 | 110293569 |
| Drug abuse | 89.62 | 12.97 | 24 | 99021 | 177387 | 110312867 |
| Yellow skin | 89.49 | 12.97 | 52 | 98993 | 4050 | 110486204 |
| Disease progression | 89.20 | 12.97 | 54 | 98991 | 243980 | 110246274 |
| Asthma | 87.89 | 12.97 | 58 | 98987 | 250233 | 110240021 |
| Haemolysis | 87.76 | 12.97 | 88 | 98957 | 15551 | 110474703 |
| Inflammation | 87.15 | 12.97 | 32 | 99013 | 193206 | 110297048 |
| Oxygen saturation decreased | 85.67 | 12.97 | 18 | 99027 | 156964 | 110333290 |
| Bursitis | 81.87 | 12.97 | 10 | 99035 | 129908 | 110360346 |
| Ill-defined disorder | 81.57 | 12.97 | 20 | 99025 | 156833 | 110333421 |
| Type 2 diabetes mellitus | 80.52 | 12.97 | 29 | 99016 | 177203 | 110313051 |
| Joint range of motion decreased | 80.26 | 12.97 | 8 | 99037 | 121824 | 110368430 |
| Discomfort | 79.18 | 12.97 | 47 | 98998 | 214660 | 110275594 |
| Cutaneous sarcoidosis | 76.84 | 12.97 | 26 | 99019 | 541 | 110489713 |
| Child-Pugh-Turcotte score increased | 76.58 | 12.97 | 16 | 99029 | 39 | 110490215 |
| Bilirubin conjugated increased | 76.49 | 12.97 | 55 | 98990 | 6169 | 110484085 |
| Infection | 74.80 | 12.97 | 131 | 98914 | 362069 | 110128185 |
| Injection site pain | 74.47 | 12.97 | 33 | 99012 | 177889 | 110312365 |
| Lung disorder | 74.41 | 12.97 | 34 | 99011 | 180013 | 110310241 |
| Ocular icterus | 73.27 | 12.97 | 53 | 98992 | 6000 | 110484254 |
| Intentional product misuse | 73.02 | 12.97 | 15 | 99030 | 132889 | 110357365 |
| Erythema multiforme | 72.55 | 12.97 | 92 | 98953 | 21005 | 110469249 |
| Gastrointestinal disorder | 71.16 | 12.97 | 67 | 98978 | 241885 | 110248369 |
| Vomiting | 70.62 | 12.97 | 1176 | 97869 | 909499 | 109580755 |
| Anger | 70.35 | 12.97 | 86 | 98959 | 18921 | 110471333 |
| Autoimmune hepatitis | 69.98 | 12.97 | 76 | 98969 | 14728 | 110475526 |
| Hypotension | 69.23 | 12.97 | 239 | 98806 | 523610 | 109966644 |
| Lower respiratory tract infection | 68.41 | 12.97 | 70 | 98975 | 243036 | 110247218 |
| Liver injury | 67.67 | 12.97 | 25 | 99020 | 150388 | 110339866 |
| Glomerulonephritis membranoproliferative | 66.57 | 12.97 | 26 | 99019 | 824 | 110489430 |
| Rash pruritic | 66.28 | 12.97 | 216 | 98829 | 97853 | 110392401 |
| Prescribed overdose | 65.68 | 12.97 | 3 | 99042 | 87578 | 110402676 |
| Facial paralysis | 65.57 | 12.97 | 94 | 98951 | 24120 | 110466134 |
| Chills | 64.44 | 12.97 | 339 | 98706 | 190241 | 110300013 |
| Arthritis | 64.20 | 12.97 | 35 | 99010 | 167551 | 110322703 |
| Gastric varices haemorrhage | 64.09 | 12.97 | 22 | 99023 | 479 | 110489775 |
| Focal segmental glomerulosclerosis | 63.61 | 12.97 | 42 | 99003 | 4103 | 110486151 |
| Intentional overdose | 63.11 | 12.97 | 20 | 99025 | 132481 | 110357773 |
| Myalgia | 62.89 | 12.97 | 377 | 98668 | 222004 | 110268250 |
| Obesity | 59.82 | 12.97 | 14 | 99031 | 113337 | 110376917 |
| Basedow's disease | 59.36 | 12.97 | 17 | 99028 | 198 | 110490056 |
| Hypoaesthesia | 59.27 | 12.97 | 120 | 98925 | 314103 | 110176151 |
| Haematemesis | 59.21 | 12.97 | 150 | 98895 | 58958 | 110431296 |
| Suicidal ideation | 59.13 | 12.97 | 202 | 98843 | 93735 | 110396519 |
| Death | 59.13 | 12.97 | 375 | 98670 | 698494 | 109791760 |
| General physical health deterioration | 58.94 | 12.97 | 190 | 98855 | 425105 | 110065149 |
| Ammonia increased | 58.83 | 12.97 | 53 | 98992 | 8197 | 110482057 |
| Pain in extremity | 57.97 | 12.97 | 232 | 98813 | 486886 | 110003368 |
| Aspartate aminotransferase increased | 57.90 | 12.97 | 290 | 98755 | 159646 | 110330608 |
| Renal failure | 57.75 | 12.97 | 374 | 98671 | 226200 | 110264054 |
| Hospitalisation | 57.20 | 12.97 | 28 | 99017 | 142465 | 110347789 |
| Psychotic disorder | 57.13 | 12.97 | 135 | 98910 | 50802 | 110439452 |
| Hepatitis C virus test positive | 55.86 | 12.97 | 19 | 99026 | 402 | 110489852 |
| Aplasia pure red cell | 55.79 | 12.97 | 55 | 98990 | 9523 | 110480731 |
| Blood pressure increased | 55.57 | 12.97 | 91 | 98954 | 258282 | 110231972 |
| Loss of personal independence in daily activities | 55.08 | 12.97 | 33 | 99012 | 149987 | 110340267 |
| Wound infection | 54.86 | 12.97 | 10 | 99035 | 96455 | 110393799 |
| Drug eruption | 54.62 | 12.97 | 137 | 98908 | 53522 | 110436732 |
| Weight decreased | 54.58 | 12.97 | 650 | 98395 | 467407 | 110022847 |
| Muscular weakness | 53.92 | 12.97 | 87 | 98958 | 248381 | 110241873 |
| Hepatitis E | 53.88 | 12.97 | 39 | 99006 | 4420 | 110485834 |
| Syncope | 53.26 | 12.97 | 337 | 98708 | 202199 | 110288055 |
| Inappropriate schedule of product administration | 52.49 | 12.97 | 63 | 98982 | 203574 | 110286680 |
| Osteoporosis | 51.86 | 12.97 | 8 | 99037 | 87144 | 110403110 |
| Disturbance in attention | 51.69 | 12.97 | 147 | 98898 | 61848 | 110428406 |
| Lip dry | 51.57 | 12.97 | 13 | 99032 | 100070 | 110390184 |
| Abdominal discomfort | 51.12 | 12.97 | 181 | 98864 | 393677 | 110096577 |
| Blood pressure systolic increased | 50.81 | 12.97 | 7 | 99038 | 82984 | 110407270 |
| Hypercholesterolaemia | 50.42 | 12.97 | 10 | 99035 | 90827 | 110399427 |
| Sedation | 50.32 | 12.97 | 3 | 99042 | 69680 | 110420574 |
| Liver transplant failure | 50.29 | 12.97 | 14 | 99031 | 146 | 110490108 |
| Live birth | 50.15 | 12.97 | 3 | 99042 | 69481 | 110420773 |
| Chronic hepatitis C | 49.85 | 12.97 | 20 | 99025 | 681 | 110489573 |
| Hepatitis C RNA | 49.81 | 12.97 | 11 | 99034 | 38 | 110490216 |
| Flushing | 49.54 | 12.97 | 16 | 99029 | 104720 | 110385534 |
| Splenomegaly | 49.39 | 12.97 | 83 | 98962 | 24415 | 110465839 |
| Blood bilirubin unconjugated increased | 48.89 | 12.97 | 23 | 99022 | 1158 | 110489096 |
| Contusion | 48.51 | 12.97 | 84 | 98961 | 233277 | 110256977 |
| Hepatic fibrosis | 48.25 | 12.97 | 47 | 98998 | 8019 | 110482235 |
| Anaphylactic reaction | 48.14 | 12.97 | 21 | 99024 | 114279 | 110375975 |
| Arthralgia | 46.98 | 12.97 | 459 | 98586 | 779173 | 109711081 |
| Gait disturbance | 46.91 | 12.97 | 113 | 98932 | 278095 | 110212159 |
| Blood pressure fluctuation | 46.55 | 12.97 | 6 | 99039 | 74818 | 110415436 |
| Exposure during pregnancy | 46.19 | 12.97 | 49 | 98996 | 167375 | 110322879 |
| Drug reaction with eosinophilia and systemic symptoms | 45.23 | 12.97 | 169 | 98876 | 81926 | 110408328 |
| Hepatic neoplasm | 44.86 | 12.97 | 33 | 99012 | 3834 | 110486420 |
| Lower limb fracture | 44.64 | 12.97 | 7 | 99038 | 75341 | 110414913 |
| Paraesthesia | 44.53 | 12.97 | 115 | 98930 | 276406 | 110213848 |
| Injection site rash | 42.84 | 12.97 | 76 | 98969 | 23343 | 110466911 |
| Optic ischaemic neuropathy | 42.80 | 12.97 | 33 | 99012 | 4114 | 110486140 |
| Sciatica | 42.16 | 12.97 | 15 | 99030 | 92384 | 110397870 |
| Cardiac failure congestive | 41.87 | 12.97 | 44 | 99001 | 150956 | 110339298 |
| Musculoskeletal pain | 41.69 | 12.97 | 62 | 98983 | 182961 | 110307293 |
| Alopecia universalis | 41.67 | 12.97 | 15 | 99030 | 377 | 110489877 |
| Upper respiratory tract infection | 41.46 | 12.97 | 34 | 99011 | 131294 | 110358960 |
| Serotonin syndrome | 41.38 | 12.97 | 3 | 99042 | 59150 | 110431104 |
| Electrocardiogram QT prolonged | 41.37 | 12.97 | 23 | 99022 | 108937 | 110381317 |
| Autoimmune thyroiditis | 41.34 | 12.97 | 39 | 99006 | 6395 | 110483859 |
| Hepatitis C virus test | 40.78 | 12.97 | 10 | 99035 | 60 | 110490194 |
| Toxic skin eruption | 40.05 | 12.97 | 81 | 98964 | 27434 | 110462820 |
| Anorectal disorder | 40.04 | 12.97 | 27 | 99018 | 2732 | 110487522 |
| Mucosal inflammation | 39.96 | 12.97 | 18 | 99027 | 96123 | 110394131 |
| Night sweats | 39.50 | 12.97 | 37 | 99008 | 133946 | 110356308 |
| Sarcoidosis | 38.81 | 12.97 | 52 | 98993 | 12527 | 110477727 |
| Hip arthroplasty | 38.56 | 12.97 | 3 | 99042 | 55810 | 110434444 |
| Nasal congestion | 38.41 | 12.97 | 20 | 99025 | 98262 | 110391992 |
| Nail disorder | 37.65 | 12.97 | 4 | 99041 | 57931 | 110432323 |
| Hepatitis cholestatic | 37.41 | 12.97 | 61 | 98984 | 17505 | 110472749 |
| Dermatitis | 37.06 | 12.97 | 79 | 98966 | 27758 | 110462496 |
| Retinal detachment | 35.96 | 12.97 | 47 | 98998 | 11053 | 110479201 |
| Therapeutic embolisation | 35.72 | 12.97 | 15 | 99030 | 575 | 110489679 |
| Incorrect route of product administration | 35.66 | 12.97 | 7 | 99038 | 64054 | 110426200 |
| Pulmonary embolism | 35.45 | 12.97 | 88 | 98957 | 214386 | 110275868 |
| Angiotensin converting enzyme increased | 34.92 | 12.97 | 11 | 99034 | 181 | 110490073 |
| Vision blurred | 34.72 | 12.97 | 216 | 98829 | 128806 | 110361448 |
| Chromaturia | 34.21 | 12.97 | 79 | 98966 | 29281 | 110460973 |
| Heart rate decreased | 33.61 | 12.97 | 16 | 99029 | 82740 | 110407514 |
| Nephrotic syndrome | 33.57 | 12.97 | 51 | 98994 | 13780 | 110476474 |
| Blister | 33.29 | 12.97 | 99 | 98946 | 227277 | 110262977 |
| Tongue pigmentation | 33.22 | 12.97 | 8 | 99037 | 44 | 110490210 |
| Blood creatinine increased | 32.92 | 12.97 | 278 | 98767 | 182611 | 110307643 |
| Alcoholism | 32.91 | 12.97 | 27 | 99018 | 3680 | 110486574 |
| Hepatic cytolysis | 32.87 | 12.97 | 5 | 99040 | 55048 | 110435206 |
| Transaminases increased | 32.86 | 12.97 | 128 | 98917 | 63262 | 110426992 |
| Drug interaction | 32.62 | 12.97 | 629 | 98416 | 499554 | 109990700 |
| Gait inability | 32.24 | 12.97 | 45 | 99000 | 136331 | 110353923 |
| Photosensitivity reaction | 32.21 | 12.97 | 71 | 98974 | 25518 | 110464736 |
| Testicular germ cell tumour mixed | 32.20 | 12.97 | 7 | 99038 | 22 | 110490232 |
| Skin disorder | 32.18 | 12.97 | 98 | 98947 | 42815 | 110447439 |
| Type 1 diabetes mellitus | 31.98 | 12.97 | 40 | 99005 | 9007 | 110481247 |
| Blood albumin decreased | 31.78 | 12.97 | 74 | 98971 | 27578 | 110462676 |
| Liver function test increased | 31.77 | 12.97 | 20 | 99025 | 88528 | 110401726 |
| Drug ineffective for unapproved indication | 30.78 | 12.97 | 28 | 99017 | 102810 | 110387444 |
| Exostosis | 30.31 | 12.97 | 3 | 99042 | 45953 | 110444301 |
| Emotional disorder | 30.28 | 12.97 | 53 | 98992 | 16107 | 110474147 |
| Alpha 1 foetoprotein increased | 30.24 | 12.97 | 15 | 99030 | 849 | 110489405 |
| Hyperthyroidism | 30.08 | 12.97 | 75 | 98970 | 29186 | 110461068 |
| Mood altered | 30.01 | 12.97 | 62 | 98983 | 21313 | 110468941 |
| Gastric varices | 30.00 | 12.97 | 15 | 99030 | 864 | 110489390 |
| Viral load | 29.90 | 12.97 | 8 | 99037 | 71 | 110490183 |
| Biliary colic | 29.80 | 12.97 | 28 | 99017 | 4569 | 110485685 |
| Acute stress disorder | 29.66 | 12.97 | 13 | 99032 | 554 | 110489700 |
| Anti-erythropoietin antibody positive | 29.57 | 12.97 | 14 | 99031 | 715 | 110489539 |
| Pulmonary fibrosis | 29.12 | 12.97 | 29 | 99016 | 102013 | 110388241 |
| Glomerulonephritis | 29.12 | 12.97 | 28 | 99017 | 4702 | 110485552 |
| Stomatitis | 28.87 | 12.97 | 134 | 98911 | 270108 | 110220146 |
| Pulmonary tuberculosis | 28.53 | 12.97 | 38 | 99007 | 9101 | 110481153 |
| Portal hypertensive gastropathy | 28.47 | 12.97 | 19 | 99026 | 1889 | 110488365 |
| Overgrowth fungal | 28.35 | 12.97 | 9 | 99036 | 152 | 110490102 |
| Aplastic anaemia | 27.88 | 12.97 | 65 | 98980 | 24243 | 110466011 |
| Myelosuppression | 27.87 | 12.97 | 26 | 99019 | 94314 | 110395940 |
| Neck pain | 27.76 | 12.97 | 42 | 99003 | 123088 | 110367166 |
| Hepatitis C RNA fluctuation | 27.75 | 12.97 | 5 | 99040 | 3 | 110490251 |
| Hypoxia | 27.47 | 12.97 | 46 | 98999 | 129469 | 110360785 |
| Plasma cell myeloma | 27.40 | 12.97 | 11 | 99034 | 62925 | 110427329 |
| Homicidal ideation | 27.25 | 12.97 | 24 | 99021 | 3603 | 110486651 |
| Paranoia | 26.95 | 12.97 | 61 | 98984 | 22313 | 110467941 |
| Pathogen resistance | 26.89 | 12.97 | 53 | 98992 | 17619 | 110472635 |
| Adverse drug reaction | 26.83 | 12.97 | 33 | 99012 | 105526 | 110384728 |
| Cardiogenic shock | 26.69 | 12.97 | 9 | 99036 | 57329 | 110432925 |
| Acute on chronic liver failure | 26.11 | 12.97 | 11 | 99034 | 425 | 110489829 |
| Erythema nodosum | 26.09 | 12.97 | 31 | 99014 | 6622 | 110483632 |
| Taste disorder | 26.01 | 12.97 | 13 | 99032 | 65374 | 110424880 |
| Asterixis | 25.96 | 12.97 | 22 | 99023 | 3136 | 110487118 |
| Hypersplenism | 25.93 | 12.97 | 13 | 99032 | 753 | 110489501 |
| Haemorrhoidal haemorrhage | 25.80 | 12.97 | 34 | 99011 | 8059 | 110482195 |
| Sudden hearing loss | 25.51 | 12.97 | 19 | 99026 | 2250 | 110488004 |
| Urate nephropathy | 25.36 | 12.97 | 9 | 99036 | 217 | 110490037 |
| Anticoagulation drug level below therapeutic | 25.24 | 12.97 | 17 | 99028 | 1717 | 110488537 |
| Cholelithiasis | 25.09 | 12.97 | 118 | 98927 | 63304 | 110426950 |
| Sudden visual loss | 24.97 | 12.97 | 7 | 99038 | 75 | 110490179 |
| Complications of transplanted liver | 24.41 | 12.97 | 11 | 99034 | 501 | 110489753 |
| Neuropathy peripheral | 24.17 | 12.97 | 81 | 98964 | 179196 | 110311058 |
| Renal disorder | 24.11 | 12.97 | 98 | 98947 | 49381 | 110440873 |
| Hepatitis virus-associated nephropathy | 24.08 | 12.97 | 4 | 99041 | 0 | 110490254 |
| Genital herpes simplex | 24.01 | 12.97 | 11 | 99034 | 521 | 110489733 |
| Adjustment disorder with depressed mood | 24.00 | 12.97 | 5 | 99040 | 43878 | 110446376 |
| Neutralising antibodies positive | 23.94 | 12.97 | 10 | 99035 | 378 | 110489876 |
| Throat irritation | 23.91 | 12.97 | 9 | 99036 | 53543 | 110436711 |
| Bleeding varicose vein | 23.84 | 12.97 | 12 | 99033 | 701 | 110489553 |
| Thought blocking | 23.83 | 12.97 | 9 | 99036 | 260 | 110489994 |
| Red blood cell sedimentation rate increased | 23.82 | 12.97 | 21 | 99024 | 78281 | 110411973 |
| Hepatic pain | 23.80 | 12.97 | 25 | 99020 | 4665 | 110485589 |
| Malaise | 23.78 | 12.97 | 778 | 98267 | 671041 | 109819213 |
| Pancreatitis acute | 23.74 | 12.97 | 112 | 98933 | 60162 | 110430092 |
| Skin irritation | 23.70 | 12.97 | 48 | 98997 | 16271 | 110473983 |
| Visual acuity reduced | 23.68 | 12.97 | 73 | 98972 | 32100 | 110458154 |
| Adverse event | 23.68 | 12.97 | 38 | 99007 | 108771 | 110381483 |
| Oral lichen planus | 23.59 | 12.97 | 13 | 99032 | 914 | 110489340 |
| Genital herpes | 23.56 | 12.97 | 19 | 99026 | 2528 | 110487726 |
| Injection site swelling | 23.52 | 12.97 | 13 | 99032 | 61777 | 110428477 |
| Coronary artery disease | 23.33 | 12.97 | 18 | 99027 | 71672 | 110418582 |
| Pneumocystis jirovecii pneumonia | 23.10 | 12.97 | 5 | 99040 | 42730 | 110447524 |
| Hepatic lesion | 23.04 | 12.97 | 33 | 99012 | 8460 | 110481794 |
| Alpha 1 foetoprotein abnormal | 22.76 | 12.97 | 6 | 99039 | 50 | 110490204 |
| Haematocrit decreased | 22.59 | 12.97 | 118 | 98927 | 65999 | 110424255 |
| Pregnancy of partner | 22.53 | 12.97 | 9 | 99036 | 303 | 110489951 |
| Rash papular | 22.51 | 12.97 | 65 | 98980 | 27574 | 110462680 |
| Amaurosis fugax | 22.47 | 12.97 | 18 | 99027 | 2372 | 110487882 |
| Anaphylactic shock | 22.46 | 12.97 | 9 | 99036 | 51537 | 110438717 |
| Photophobia | 22.35 | 12.97 | 62 | 98983 | 25709 | 110464545 |
| Product prescribing error | 22.30 | 12.97 | 9 | 99036 | 51322 | 110438932 |
| Diverticulitis | 22.27 | 12.97 | 10 | 99035 | 53512 | 110436742 |
| Pneumonia aspiration | 22.15 | 12.97 | 24 | 99021 | 81209 | 110409045 |
| Muscle spasticity | 22.05 | 12.97 | 3 | 99042 | 35912 | 110454342 |
| Blood uric acid increased | 21.94 | 12.97 | 55 | 98990 | 21474 | 110468780 |
| Dehydration | 21.92 | 12.97 | 362 | 98683 | 279149 | 110211105 |
| Frequent bowel movements | 21.89 | 12.97 | 19 | 99026 | 71371 | 110418883 |
| Autoimmune disorder | 21.87 | 12.97 | 16 | 99029 | 65467 | 110424787 |
| Oedema due to hepatic disease | 21.87 | 12.97 | 5 | 99040 | 21 | 110490233 |
| Angioedema | 21.82 | 12.97 | 34 | 99011 | 98466 | 110391788 |
| Coma hepatic | 21.78 | 12.97 | 13 | 99032 | 1064 | 110489190 |
| Oral mucosal blistering | 21.77 | 12.97 | 31 | 99014 | 7903 | 110482351 |
| Procedural pain | 21.77 | 12.97 | 3 | 99042 | 35562 | 110454692 |
| Joint stiffness | 21.73 | 12.97 | 17 | 99028 | 67226 | 110423028 |
| Mental disorder | 21.48 | 12.97 | 80 | 98965 | 38711 | 110451543 |
| Immune thrombocytopenia | 21.40 | 12.97 | 56 | 98989 | 22438 | 110467816 |
| Faeces discoloured | 21.35 | 12.97 | 73 | 98972 | 33875 | 110456379 |
| Accidental exposure to product | 21.35 | 12.97 | 9 | 99036 | 49999 | 110440255 |
| Rhinorrhoea | 21.28 | 12.97 | 37 | 99008 | 102629 | 110387625 |
| Basal cell carcinoma | 21.26 | 12.97 | 7 | 99038 | 45263 | 110444991 |
| Face oedema | 21.08 | 12.97 | 72 | 98973 | 33397 | 110456857 |
| Remission not achieved | 21.01 | 12.97 | 10 | 99035 | 517 | 110489737 |
| Injection site dermatitis | 21.00 | 12.97 | 5 | 99040 | 26 | 110490228 |
| Skin lesion | 20.38 | 12.97 | 96 | 98949 | 51535 | 110438719 |
| Migraine | 20.22 | 12.97 | 82 | 98963 | 171570 | 110318684 |
| Depressed level of consciousness | 20.21 | 12.97 | 44 | 99001 | 112234 | 110378020 |
| Colitis | 20.21 | 12.97 | 38 | 99007 | 102285 | 110387969 |
| Immunodeficiency | 20.09 | 12.97 | 5 | 99040 | 38833 | 110451421 |
| Transplant failure | 20.05 | 12.97 | 25 | 99020 | 5610 | 110484644 |
| Stress | 20.04 | 12.97 | 40 | 99005 | 105308 | 110384946 |
| Chest discomfort | 19.89 | 12.97 | 84 | 98961 | 173764 | 110316490 |
| Orthostatic hypotension | 19.87 | 12.97 | 18 | 99027 | 66231 | 110424023 |
| Chronic hepatic failure | 19.80 | 12.97 | 13 | 99032 | 1258 | 110488996 |
| Blood bilirubin abnormal | 19.70 | 12.97 | 15 | 99030 | 1835 | 110488419 |
| Lupus-like syndrome | 19.70 | 12.97 | 6 | 99039 | 40786 | 110449468 |
| Hepatic function abnormal | 19.52 | 12.97 | 142 | 98903 | 89153 | 110401101 |
| Gingival bleeding | 19.50 | 12.97 | 50 | 98995 | 19789 | 110470465 |
| Back injury | 19.50 | 12.97 | 9 | 99036 | 47390 | 110442864 |
| Hepatic mass | 19.46 | 12.97 | 18 | 99027 | 2880 | 110487374 |
| Sleep apnoea syndrome | 19.44 | 12.97 | 6 | 99039 | 40441 | 110449813 |
| Affect lability | 19.40 | 12.97 | 48 | 98997 | 18589 | 110471665 |
| Therapy responder | 19.32 | 12.97 | 9 | 99036 | 443 | 110489811 |
| Transplant rejection | 19.27 | 12.97 | 57 | 98988 | 24510 | 110465744 |
| Infection in an immunocompromised host | 19.16 | 12.97 | 15 | 99030 | 1912 | 110488342 |
| Bacterascites | 19.07 | 12.97 | 4 | 99041 | 10 | 110490244 |
| Hepatorenal failure | 19.00 | 12.97 | 13 | 99032 | 1347 | 110488907 |
| Delirium | 18.90 | 12.97 | 60 | 98985 | 134965 | 110355289 |
| Respiratory depression | 18.89 | 12.97 | 3 | 99042 | 31998 | 110458256 |
| Optic neuropathy | 18.75 | 12.97 | 22 | 99023 | 4636 | 110485618 |
| Device issue | 18.75 | 12.97 | 4 | 99041 | 34531 | 110455723 |
| Device related infection | 18.75 | 12.97 | 6 | 99039 | 39513 | 110450741 |
| Ammonia abnormal | 18.64 | 12.97 | 8 | 99037 | 324 | 110489930 |
| Tinnitus | 18.63 | 12.97 | 105 | 98940 | 60435 | 110429819 |
| Respiratory arrest | 18.51 | 12.97 | 15 | 99030 | 58284 | 110431970 |
| Extradural abscess | 18.45 | 12.97 | 15 | 99030 | 2019 | 110488235 |
| Hepatopulmonary syndrome | 18.44 | 12.97 | 7 | 99038 | 205 | 110490049 |
| Clostridium difficile infection | 18.39 | 12.97 | 12 | 99033 | 52117 | 110438137 |
| Sopor | 18.34 | 12.97 | 5 | 99040 | 36541 | 110453713 |
| Surgery | 18.33 | 12.97 | 7 | 99038 | 41276 | 110448978 |
| Ocular sarcoidosis | 18.10 | 12.97 | 6 | 99039 | 117 | 110490137 |
| Chronic hepatitis | 18.07 | 12.97 | 14 | 99031 | 1758 | 110488496 |
| Model for end stage liver disease score | 18.06 | 12.97 | 3 | 99042 | 0 | 110490254 |
| Transfusion | 18.02 | 12.97 | 57 | 98988 | 25415 | 110464839 |
| Retinal vein occlusion | 17.95 | 12.97 | 20 | 99025 | 3987 | 110486267 |
| Hair disorder | 17.95 | 12.97 | 12 | 99033 | 1197 | 110489057 |
| Muscle spasms | 17.88 | 12.97 | 161 | 98884 | 277996 | 110212258 |
| Chronic obstructive pulmonary disease | 17.86 | 12.97 | 45 | 99000 | 109113 | 110381141 |
| Mitochondrial toxicity | 17.73 | 12.97 | 18 | 99027 | 3227 | 110487027 |
| Pancreas transplant rejection | 17.68 | 12.97 | 8 | 99037 | 368 | 110489886 |
| Cheilitis | 17.66 | 12.97 | 25 | 99020 | 6340 | 110483914 |
| Acute respiratory failure | 17.62 | 12.97 | 25 | 99020 | 75235 | 110415019 |
| Cerebrovascular accident | 17.56 | 12.97 | 93 | 98952 | 181191 | 110309063 |
| Respiratory disorder | 17.43 | 12.97 | 23 | 99022 | 71359 | 110418895 |
| Cardiac arrest | 17.40 | 12.97 | 104 | 98941 | 196649 | 110293605 |
| Hepatitis B | 17.33 | 12.97 | 31 | 99014 | 9581 | 110480673 |
| Hip fracture | 17.29 | 12.97 | 5 | 99040 | 35146 | 110455108 |
| Pityriasis | 17.27 | 12.97 | 4 | 99041 | 18 | 110490236 |
| Psoriasis | 17.05 | 12.97 | 66 | 98979 | 139927 | 110350327 |
| Facial paresis | 16.95 | 12.97 | 24 | 99021 | 6089 | 110484165 |
| Hydrocholecystis | 16.95 | 12.97 | 9 | 99036 | 588 | 110489666 |
| VIIIth nerve lesion | 16.93 | 12.97 | 4 | 99041 | 20 | 110490234 |
| Body temperature decreased | 16.84 | 12.97 | 6 | 99039 | 36929 | 110453325 |
| Labelled drug-drug interaction medication error | 16.74 | 12.97 | 3 | 99042 | 29299 | 110460955 |
| Abnormal dreams | 16.70 | 12.97 | 36 | 99009 | 12744 | 110477510 |
| Lymphocyte count decreased | 16.64 | 12.97 | 16 | 99029 | 57227 | 110433027 |
| Portopulmonary hypertension | 16.63 | 12.97 | 6 | 99039 | 152 | 110490102 |
| Poisoning | 16.58 | 12.97 | 3 | 99042 | 29102 | 110461152 |
| Palmar-plantar erythrodysaesthesia syndrome | 16.55 | 12.97 | 8 | 99037 | 41017 | 110449237 |
| Lymph node tuberculosis | 16.49 | 12.97 | 11 | 99034 | 1093 | 110489161 |
| Pain in jaw | 16.46 | 12.97 | 13 | 99032 | 51164 | 110439090 |
| Tachycardia | 16.46 | 12.97 | 127 | 98918 | 226518 | 110263736 |
| Movement disorder | 16.45 | 12.97 | 6 | 99039 | 36398 | 110453856 |
| Limb discomfort | 16.43 | 12.97 | 8 | 99037 | 40846 | 110449408 |
| Therapeutic response decreased | 16.40 | 12.97 | 39 | 99006 | 96460 | 110393794 |
| Therapy non-responder | 16.37 | 12.97 | 214 | 98831 | 157093 | 110333161 |
| Suspected transmission of an infectious agent via product | 16.36 | 12.97 | 12 | 99033 | 1388 | 110488866 |
| Serum ferritin increased | 16.21 | 12.97 | 34 | 99011 | 11813 | 110478441 |
| Blood pressure diastolic decreased | 16.07 | 12.97 | 6 | 99039 | 35879 | 110454375 |
| Exposure via direct contact | 16.06 | 12.97 | 5 | 99040 | 79 | 110490175 |
| Deafness unilateral | 16.00 | 12.97 | 20 | 99025 | 4499 | 110485755 |
| Oesophageal variceal ligation | 15.96 | 12.97 | 6 | 99039 | 171 | 110490083 |
| Exposure via partner | 15.91 | 12.97 | 4 | 99041 | 27 | 110490227 |
| Wrong technique in product usage process | 15.91 | 12.97 | 34 | 99011 | 87314 | 110402940 |
| Viraemia | 15.90 | 12.97 | 19 | 99026 | 4083 | 110486171 |
| Intervertebral discitis | 15.88 | 12.97 | 25 | 99020 | 6965 | 110483289 |
| Gene mutation identification test positive | 15.87 | 12.97 | 7 | 99038 | 303 | 110489951 |
| Epilepsy | 15.87 | 12.97 | 42 | 99003 | 100167 | 110390087 |
| Procalcitonin | 15.78 | 12.97 | 4 | 99041 | 28 | 110490226 |
| Myoclonus | 15.67 | 12.97 | 5 | 99040 | 32993 | 110457261 |
| Haematotoxicity | 15.67 | 12.97 | 48 | 98997 | 21034 | 110469220 |
| Bulimia nervosa | 15.66 | 12.97 | 7 | 99038 | 313 | 110489941 |
| Haemorrhoids thrombosed | 15.61 | 12.97 | 7 | 99038 | 315 | 110489939 |
| Overdose | 15.61 | 12.97 | 134 | 98911 | 233660 | 110256594 |
| Hypoalbuminaemia | 15.42 | 12.97 | 59 | 98986 | 28915 | 110461339 |
| COVID-19 pneumonia | 15.36 | 12.97 | 7 | 99038 | 37136 | 110453118 |
| Excessive dynamic airway collapse | 15.10 | 12.97 | 4 | 99041 | 34 | 110490220 |
| Retinal vein thrombosis | 15.07 | 12.97 | 9 | 99036 | 737 | 110489517 |
| Sleep disorder | 15.05 | 12.97 | 110 | 98935 | 198534 | 110291720 |
| Granulomatous liver disease | 15.04 | 12.97 | 12 | 99033 | 1572 | 110488682 |
| Colitis ulcerative | 15.04 | 12.97 | 29 | 99016 | 77334 | 110412920 |
| Joint dislocation | 14.84 | 12.97 | 6 | 99039 | 34184 | 110456070 |
| Haemophilic arthropathy | 14.77 | 12.97 | 6 | 99039 | 211 | 110490043 |
| Congenital uterine anomaly | 14.77 | 12.97 | 3 | 99042 | 6 | 110490248 |
| Deafness | 14.72 | 12.97 | 55 | 98990 | 26654 | 110463600 |
| Laryngitis | 14.64 | 12.97 | 10 | 99035 | 42401 | 110447853 |
| Fat intolerance | 14.61 | 12.97 | 4 | 99041 | 39 | 110490215 |
| Hepatic amoebiasis | 14.56 | 12.97 | 5 | 99040 | 109 | 110490145 |
| Neurotoxicity | 14.51 | 12.97 | 10 | 99035 | 42197 | 110448057 |
| Paraesthesia oral | 14.47 | 12.97 | 6 | 99039 | 33665 | 110456589 |
| Cerebral arteriovenous malformation haemorrhagic | 14.45 | 12.97 | 3 | 99042 | 7 | 110490247 |
| Hyperlipidaemia | 14.45 | 12.97 | 7 | 99038 | 35841 | 110454413 |
| Blood disorder | 14.42 | 12.97 | 29 | 99016 | 9781 | 110480473 |
| Bone marrow failure | 14.42 | 12.97 | 95 | 98950 | 57753 | 110432501 |
| Gallbladder cancer | 14.40 | 12.97 | 8 | 99037 | 572 | 110489682 |
| Lung abscess | 14.37 | 12.97 | 20 | 99025 | 4992 | 110485262 |
| Throat tightness | 14.34 | 12.97 | 6 | 99039 | 33483 | 110456771 |
| Generalised oedema | 14.32 | 12.97 | 60 | 98985 | 30644 | 110459610 |
| Peritoneal tuberculosis | 14.27 | 12.97 | 8 | 99037 | 582 | 110489672 |
| Epistaxis | 14.26 | 12.97 | 179 | 98866 | 130193 | 110360061 |
| Prostate cancer | 14.21 | 12.97 | 8 | 99037 | 37633 | 110452621 |
| Tendonitis | 14.21 | 12.97 | 3 | 99042 | 26080 | 110464174 |
| Limb injury | 14.20 | 12.97 | 8 | 99037 | 37628 | 110452626 |
| Prurigo | 14.14 | 12.97 | 11 | 99034 | 1389 | 110488865 |
| International normalised ratio decreased | 14.13 | 12.97 | 26 | 99019 | 8210 | 110482044 |
| Myelodysplastic syndrome | 14.10 | 12.97 | 8 | 99037 | 37476 | 110452778 |
| Sinus congestion | 13.80 | 12.97 | 5 | 99040 | 30454 | 110459800 |
| Hepatitis C antibody positive | 13.79 | 12.97 | 6 | 99039 | 251 | 110490003 |
| Anaemia macrocytic | 13.74 | 12.97 | 24 | 99021 | 7279 | 110482975 |
| Depressive symptom | 13.74 | 12.97 | 26 | 99019 | 8388 | 110481866 |
| Incorrect product administration duration | 13.71 | 12.97 | 45 | 99000 | 20453 | 110469801 |
| Deafness neurosensory | 13.62 | 12.97 | 28 | 99017 | 9591 | 110480663 |
| Somnolence | 13.61 | 12.97 | 186 | 98859 | 297263 | 110192991 |
| Cataract | 13.61 | 12.97 | 32 | 99013 | 79453 | 110410801 |
| CD4 lymphocytes decreased | 13.59 | 12.97 | 15 | 99030 | 2959 | 110487295 |
| Portal vein flow decreased | 13.57 | 12.97 | 4 | 99041 | 52 | 110490202 |
| Disorientation | 13.55 | 12.97 | 109 | 98936 | 70562 | 110419692 |
| Retinitis | 13.51 | 12.97 | 6 | 99039 | 32321 | 110457933 |
| Bronchitis | 13.36 | 12.97 | 84 | 98961 | 156948 | 110333306 |
| Medication error | 13.26 | 12.97 | 49 | 98996 | 105317 | 110384937 |
| Cortisol free urine decreased | 13.24 | 12.97 | 3 | 99042 | 12 | 110490242 |
| Hyperalbuminaemia | 13.23 | 12.97 | 4 | 99041 | 57 | 110490197 |
| Alcohol abuse | 13.15 | 12.97 | 19 | 99026 | 4910 | 110485344 |
| Influenza | 13.12 | 12.97 | 93 | 98952 | 169008 | 110321246 |
| Acute hepatic failure | 13.10 | 12.97 | 66 | 98979 | 36402 | 110453852 |
| Oral tuberculosis | 13.05 | 12.97 | 3 | 99042 | 13 | 110490241 |
| Osteonecrosis | 12.98 | 12.97 | 7 | 99038 | 33734 | 110456520 |
FDA Adverse Event Reporting System (Pediatric)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Maternal drugs affecting foetus | 10.58 | 10.41 | 3 | 3 | 842 | 113105 |
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | J05AP01 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIVIRALS FOR SYSTEMIC USE DIRECT ACTING ANTIVIRALS Antivirals for treatment of HCV infections |
| FDA EXT | N0000175459 | Nucleoside Analog |
| FDA EPC | N0000175466 | Nucleoside Analog Antiviral |
| MeSH PA | D000890 | Anti-Infective Agents |
| MeSH PA | D000963 | Antimetabolites |
| MeSH PA | D000998 | Antiviral Agents |
| CHEBI has role | CHEBI:22587 | antiviral agent |
| CHEBI has role | CHEBI:35221 | antimetabolite |
| CHEBI has role | CHEBI:35441 | antiinfective agent |
| CHEBI has role | CHEBI:35469 | antidepressant |
| CHEBI has role | CHEBI:35526 | hypoglycemic agent |
| CHEBI has role | CHEBI:35610 | antineoplastic agent |
| CHEBI has role | CHEBI:59897 | EC 2.7.7.49 (RNA-directed DNA polymerase) inhibitor |
| CHEBI has role | CHEBI:62868 | hepatoprotective agent |
| CHEBI has role | CHEBI:64946 | anti-HIV agent |
| CHEBI has role | CHEBI:64951 | anti-HBV agent |
| CHEBI has role | CHEBI:149553 | anticoronaviral agent |
| CHEBI has role | CHEBI:233423 | antifibrotic agent |
Related Drugs by ATC class:
J05AP Antivirals for treatment of HCV infections 18 drugs
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Respiratory syncytial virus infection | indication | 55735004 | DOID:1273 |
| Chronic hepatitis C | indication | 128302006 | |
| Compensated cirrhosis | indication | 371139006 | |
| Lassa fever | off-label use | 19065005 | DOID:9537 |
| Influenza due to Influenza virus, type B | off-label use | 24662006 | |
| Congo-Crimean hemorrhagic fever | off-label use | 43489008 | DOID:12287 |
| Hemorrhagic nephroso-nephritis | off-label use | 102455002 | |
| Coronavirus infection | off-label use | 186747009 | |
| Rift valley fever | off-label use | 402917003 | DOID:1328 |
| Influenza due to Influenza A virus | off-label use | 442438000 | |
| Chronic obstructive lung disease | contraindication | 13645005 | DOID:3083 |
| Cirrhosis of liver | contraindication | 19943007 | DOID:5082 |
| Myocardial infarction | contraindication | 22298006 | DOID:5844 |
| Constitutional aplastic anemia | contraindication | 28975000 | DOID:1342 |
| Sarcoidosis | contraindication | 31541009 | DOID:11335 |
| Thalassemia | contraindication | 40108008 | DOID:10241 |
| Periodontitis | contraindication | 41565005 | DOID:824 |
| Coronary arteriosclerosis | contraindication | 53741008 | DOID:3393 |
| Hemolytic anemia | contraindication | 61261009 | DOID:583 |
| Interstitial pneumonia | contraindication | 64667001 | |
| Pancreatitis | contraindication | 75694006 | DOID:4989 |
| Pancytopenia | contraindication | 127034005 | DOID:12450 |
| Hb SS disease | contraindication | 127040003 | DOID:10923 |
| Asthma | contraindication | 195967001 | DOID:2841 |
| Impaired renal function disorder | contraindication | 197663003 | |
| Anemia | contraindication | 271737000 | DOID:2355 |
| Pregnancy, function | contraindication | 289908002 | |
| Bone marrow depression | contraindication | 307762000 | |
| Autoimmune hepatitis | contraindication | 408335007 | |
| Breastfeeding (mother) | contraindication | 413712001 | |
| Myocardial ischemia | contraindication | 414795007 | DOID:3393 |
| Pulmonary Infiltrates | contraindication |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 11.65 | acidic |
| pKa2 | 12.27 | acidic |
| pKa3 | 13.44 | acidic |
| pKa4 | 0.35 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Inosine-5'-monophosphate dehydrogenase 1 | Enzyme | INHIBITOR | IC50 | 6 | IUPHAR | CHEMBL | |||
| Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 | Enzyme | WOMBAT-PK | |||||||
| Cytosolic purine 5'-nucleotidase | Enzyme | WOMBAT-PK | |||||||
| Inosine-5'-monophosphate dehydrogenase 2 | Enzyme | INHIBITOR | IC50 | 6 | IUPHAR | ||||
| DNA topoisomerase 1 | Enzyme | IC50 | 4.18 | CHEMBL | |||||
| Eukaryotic translation initiation factor 4E | Nuclear other | Kd | 5.08 | CHEMBL | |||||
| Adenosine receptor A1 | GPCR | Ki | 5.13 | CHEMBL | |||||
| Adenosine kinase | Kinase | WOMBAT-PK | |||||||
| NS5B protein | Enzyme | INHIBITOR | CHEMBL | CHEMBL | |||||
| NS5 | Enzyme | EC50 | 4.68 | CHEMBL | |||||
| Adenosine receptor A1 | GPCR | Ki | 5.35 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| 4019299 | VUID |
| N0000147496 | NUI |
| D00423 | KEGG_DRUG |
| 4019299 | VANDF |
| C0035525 | UMLSCUI |
| CHEBI:63580 | CHEBI |
| RBV | PDB_CHEM_ID |
| CHEMBL1643 | ChEMBL_ID |
| DB00811 | DRUGBANK_ID |
| D012254 | MESH_DESCRIPTOR_UI |
| 37542 | PUBCHEM_CID |
| 6842 | IUPHAR_LIGAND_ID |
| 3543 | INN_ID |
| 49717AWG6K | UNII |
| 9344 | RXNORM |
| 43465 | MMSL |
| 5421 | MMSL |
| d00085 | MMSL |
| 003018 | NDDF |
| 35063004 | SNOMEDCT_US |
| 387188005 | SNOMEDCT_US |
| 49717AWG6K | INXIGHT DRUGS |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| Ribavirin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 53808-0781 | CAPSULE | 200 mg | ORAL | ANDA | 21 sections |
| Ribavirin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 53808-0782 | TABLET, FILM COATED | 200 mg | ORAL | ANDA | 16 sections |
| Ribavirin | Human Prescription Drug Label | 1 | 65862-207 | TABLET, FILM COATED | 200 mg | ORAL | ANDA | 27 sections |
| Ribavirin | Human Prescription Drug Label | 1 | 65862-290 | CAPSULE | 200 mg | ORAL | ANDA | 28 sections |
| RIBAVIRIN | HUMAN PRESCRIPTION DRUG LABEL | 1 | 68382-395 | POWDER, FOR SOLUTION | 6 g | RESPIRATORY (INHALATION) | ANDA | 19 sections |
| RIBAVIRIN | HUMAN PRESCRIPTION DRUG LABEL | 1 | 68475-003 | POWDER, FOR SOLUTION | 6 g | RESPIRATORY (INHALATION) | ANDA | 19 sections |
| Ribavirin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 68682-019 | POWDER, FOR SOLUTION | 6 g | RESPIRATORY (INHALATION) | NDA | 21 sections |
| Ribavirin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 72162-1331 | POWDER, FOR SOLUTION | 6 g | RESPIRATORY (INHALATION) | NDA | 22 sections |