tasonermin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
tumour necrosis factor 5212 94948-59-1

Description:

MoleculeDescription

Synonyms:

  • tasonermin
  • beromun
Tasonermin, is a copy of the human protein tumour necrosis factor alfa-1a (TNF-alfa). The exact way that TNF-alfa works against certain types of cancer is not fully understood, but it is thought that it can kill tumour cells directly, as well as destroy the blood vessels supplying tumours and stimulate the immune system to attack them. This leads to the tumour dying back and getting smaller, particularly when the medicine is combined with other cytotoxic (cell-killing) medicines and raised temperature.
  • Molecular weight: 17350.75
  • Formula: C778H1225N215O231S2
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA: 7163.87
  • ALOGS:
  • ROTB: None

Drug dosage:

DoseUnitRoute
3.50 mg P

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

None

Approvals:

DateAgencyCompanyOrphan
April 13, 1999 EMA Boehringer Ingelheim International GmbH

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC L03AX11 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
IMMUNOSTIMULANTS
IMMUNOSTIMULANTS
Other immunostimulants
CHEBI has role CHEBI:35610 antineoplastic agent

Related Drugs by ATC class:

L03AX Other immunostimulants 15 drugs
cridanimodelapegademaseglatiramer acetatehistamineleniolisiblentinanmavorixaformifamurtidemotixafortidepegademasepidotimodplerixafor show all 15 →

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Sarcoma of soft tissue indication 424952003




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
23CA79S88F UNII
C0937851 UMLSCUI
CHEBI:752933 CHEBI
CHEMBL2107891 ChEMBL_ID
DB11626 DRUGBANK_ID
D08562 KEGG_DRUG
7581 INN_ID
421147008 SNOMEDCT_US
421457001 SNOMEDCT_US
008935 NDDF
283746 RXNORM

Pharmaceutical products:

None