carumonam Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
monobactam antibiotics 521 87638-04-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • carumonam
  • Molecular weight: 466.40
  • Formula: C12H14N6O10S2
  • CLOGP: -1.25
  • LIPINSKI: 1
  • HAC: 16
  • HDO: 5
  • TPSA: 253.90
  • ALOGS: -3.17
  • ROTB: 9

Drug dosage:

DoseUnitRoute
2 g P

ADMET properties:

PropertyValueReference
Vd (Volume of distribution) 0.18 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 1.50 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.72 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 1.60 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Jan. 1, 1988 YEAR INTRODUCED

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
ATC J01DF02 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIBACTERIALS FOR SYSTEMIC USE
OTHER BETA-LACTAM ANTIBACTERIALS
Monobactams
CHEBI has role CHEBI:36047 antibacterial drug

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 2.45 acidic
pKa2 13.2 acidic
pKa3 3.1 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Peptidoglycan synthase FtsI Enzyme WOMBAT-PK

External reference:

IDSource
D07625 KEGG_DRUG
486890PI06 UNII
5508 INN_ID
010921 NDDF
C044145 MESH_SUPPLEMENTAL_RECORD_UI
CHEBI:55486 CHEBI
DB13553 DRUGBANK_ID
CHEMBL1614658 ChEMBL_ID
6540466 PUBCHEM_CID

Pharmaceutical products:

None