icotinib 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| tyrosine kinase inhibitors | 5209 | 610798-31-7 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
Icotinib is a new epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) that developed and used in China for the treatment of patients with non-small cell lung cancer (NSCLC).
|
Drug dosage:
None
ADMET properties:
None
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| None | China Food and Drug Administration (CFDA) | Zhejiang Beta Pharma Inc. |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | L01EB08 | ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS ANTINEOPLASTIC AGENTS PROTEIN KINASE INHIBITORS Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Non-small cell lung cancer | indication | 254637007 | DOID:3908 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 4.01 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Epidermal growth factor receptor | Kinase | INHIBITOR | IC50 | 8.70 | SCIENTIFIC LITERATURE | SCIENTIFIC LITERATURE | |||
| Cyclin-G-associated kinase | Kinase | Kd | 6.14 | CHEMBL | |||||
| Receptor-interacting serine/threonine-protein kinase 2 | Kinase | Kd | 5.58 | CHEMBL | |||||
| STE20-like serine/threonine-protein kinase | Kinase | Kd | 5.98 | CHEMBL | |||||
| Serine/threonine-protein kinase 10 | Kinase | Kd | 6.64 | CHEMBL | |||||
| Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma | Kinase | Kd | 5.33 | CHEMBL | |||||
| Mitotic checkpoint serine/threonine-protein kinase BUB1 | Kinase | Kd | 5.54 | CHEMBL | |||||
| Cysteine--tRNA ligase, cytoplasmic | Enzyme | Kd | 6.19 | CHEMBL | |||||
| Mitogen-activated protein kinase kinase kinase 1 | Kinase | Kd | 5.38 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| 9G6U5L461Q | UNII |
| 1204313-51-8 | SECONDARY_CAS_RN |
| C2604307 | UMLSCUI |
| CHEMBL2087361 | ChEMBL_ID |
| 22024915 | PUBCHEM_CID |
| DB11737 | DRUGBANK_ID |
| CHEMBL4297665 | ChEMBL_ID |
| 7641 | IUPHAR_LIGAND_ID |
| C531470 | MESH_SUPPLEMENTAL_RECORD_UI |
Pharmaceutical products:
None