nadroparin calcium 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	5162	37270-89-6

Description:

Molecule	Description
Synonyms: nadroparin nadroparin calcium fraxiparine fraxiparin	A low molecular weight heparin (LMWH) composed of a heterogeneous mixture of sulfated polysaccharide glycosaminoglycan chains obtained by depolymerisation of porcine mucosal sodium heparin, extraction/purification and conversion to the calcium salt. Nadroparin binds to antithrombin III (ATIII) and inhibits the activity of activated factor X (factor Xa), thereby inhibiting the final common pathway of the coagulation cascade and preventing the formation of a cross-linked fibrin clot Molecular weight: Formula: CLOGP: LIPINSKI: None HAC: None HDO: None TPSA: ALOGS: ROTB: None

Molecule

Description

Synonyms:

nadroparin
nadroparin calcium
fraxiparine
fraxiparin

A low molecular weight heparin (LMWH) composed of a heterogeneous mixture of sulfated polysaccharide glycosaminoglycan chains obtained by depolymerisation of porcine mucosal sodium heparin, extraction/purification and conversion to the calcium salt. Nadroparin binds to antithrombin III (ATIII) and inhibits the activity of activated factor X (factor Xa), thereby inhibiting the final common pathway of the coagulation cascade and preventing the formation of a cross-linked fibrin clot

Molecular weight:
Formula:
CLOGP:
LIPINSKI: None
HAC: None
HDO: None
TPSA:
ALOGS:
ROTB: None

Drug dosage:

Dose	Unit	Route
2.85	TU	P

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
None	Health Canada

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Lymphatic fistula	96.53	25.37	20	4767	766	63483469
Femoral hernia incarcerated	95.18	25.37	20	4767	821	63483414
Pancreatic steatosis	91.42	25.37	20	4767	996	63483239
Wound dehiscence	89.30	25.37	27	4760	4876	63479359
Wound infection pseudomonas	86.08	25.37	20	4767	1308	63482927
Arterial haemorrhage	86.04	25.37	21	4766	1696	63482539
Seroma	81.54	25.37	21	4766	2110	63482125
Haemarthrosis	73.33	25.37	21	4766	3140	63481095
Aortic valve stenosis	72.45	25.37	21	4766	3278	63480957
Premature baby	72.38	25.37	34	4753	20701	63463534
Tachyarrhythmia	70.41	25.37	22	4765	4428	63479807
Maternal exposure during pregnancy	66.06	25.37	82	4705	219980	63264255
Hepatic cyst	63.22	25.37	21	4766	5133	63479102
Premature delivery	62.94	25.37	35	4752	30246	63453989
Diverticulum intestinal	61.54	25.37	22	4765	6691	63477544
Aortic arteriosclerosis	59.39	25.37	21	4766	6188	63478047
Faecaloma	57.93	25.37	22	4765	7919	63476316
Inflammatory marker increased	57.40	25.37	21	4766	6818	63477417
Eructation	53.37	25.37	21	4766	8312	63475923
Hyponatraemia	53.04	25.37	53	4734	111847	63372388
Oligohydramnios	51.41	25.37	19	4768	6347	63477888
Aplastic anaemia	50.56	25.37	21	4766	9548	63474687
Groin pain	49.26	25.37	21	4766	10182	63474053
Foetal growth restriction	48.25	25.37	19	4768	7534	63476701
Foetal exposure during pregnancy	48.14	25.37	30	4757	31932	63452303
Haematuria	48.08	25.37	29	4758	29128	63455107
Escherichia infection	47.87	25.37	22	4765	12732	63471503
Cardiovascular disorder	46.30	25.37	21	4766	11791	63472444
Left ventricular dysfunction	46.00	25.37	21	4766	11967	63472268
Anuria	45.08	25.37	21	4766	12530	63471705
Postoperative wound infection	44.66	25.37	20	4767	10905	63473330
Mitral valve incompetence	44.44	25.37	24	4763	19570	63464665
Urinary retention	42.03	25.37	27	4760	30274	63453961
Joint dislocation	39.79	25.37	22	4765	18778	63465457
Tricuspid valve incompetence	39.10	25.37	20	4767	14601	63469634
Anaemia	38.98	25.37	75	4712	293355	63190880
Cardiogenic shock	37.99	25.37	21	4766	17911	63466324
Myelodysplastic syndrome	36.54	25.37	20	4767	16734	63467501
Pulmonary hypertension	34.81	25.37	26	4761	37097	63447138
Osteopenia	33.44	25.37	20	4767	19765	63464470
Hiatus hernia	31.83	25.37	20	4767	21574	63462661
Oedema peripheral	30.92	25.37	53	4734	189458	63294777
Coronary artery disease	28.85	25.37	22	4765	32355	63451880
Low birth weight baby	25.82	25.37	12	4775	7117	63477118

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Pulmonary embolism	47.05	22.77	49	3146	89697	34864039
Suture rupture	41.16	22.77	9	3186	367	34953369
Herpes zoster reactivation	31.76	22.77	7	3188	296	34953440
Erysipelas	31.36	22.77	13	3182	4850	34948886
Soft tissue disorder	30.16	22.77	8	3187	742	34952994
Lymphocele	29.70	22.77	9	3186	1348	34952388
Umbilical hernia	28.47	22.77	12	3183	4665	34949071
Device related infection	27.46	22.77	18	3177	17219	34936517
Autoimmune disorder	27.22	22.77	9	3186	1785	34951951
Acetabulum fracture	26.40	22.77	6	3189	292	34953444
SARS-CoV-2 sepsis	25.15	22.77	5	3190	127	34953609
Haemolytic uraemic syndrome	25.09	22.77	9	3186	2277	34951459
Hypothalamo-pituitary disorder	24.76	22.77	7	3188	823	34952913
Scrotal pain	24.15	22.77	7	3188	899	34952837
Respiratory failure	23.07	22.77	38	3157	108534	34845202

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Lymphatic fistula	92.02	19.58	20	7353	783	79736232
Femoral hernia incarcerated	91.08	19.58	20	7353	822	79736193
Wound dehiscence	87.55	19.58	30	7343	6565	79730450
Pancreatic steatosis	84.96	19.58	20	7353	1125	79735890
Wound infection pseudomonas	78.05	19.58	20	7353	1601	79735414
Seroma	75.69	19.58	21	7352	2279	79734736
Arterial haemorrhage	73.45	19.58	21	7352	2540	79734475
Tachyarrhythmia	63.53	19.58	24	7349	6938	79730077
Aortic valve stenosis	58.46	19.58	21	7352	5273	79731742
Haemarthrosis	56.54	19.58	21	7352	5791	79731224
Hepatic cyst	55.59	19.58	21	7352	6068	79730947
Faecaloma	54.91	19.58	25	7348	11539	79725476
Maternal exposure during pregnancy	54.33	19.58	65	7308	136473	79600542
Hyponatraemia	52.47	19.58	73	7300	177775	79559240
Diverticulum intestinal	51.86	19.58	22	7351	8583	79728432
Aortic arteriosclerosis	47.84	19.58	21	7352	8897	79728118
Inflammatory marker increased	47.18	19.58	22	7351	10718	79726297
Escherichia infection	44.42	19.58	25	7348	17992	79719023
Eructation	43.79	19.58	21	7352	10888	79726127
Postoperative wound infection	43.25	19.58	22	7351	12939	79724076
Groin pain	40.18	19.58	21	7352	13059	79723956
Premature delivery	38.31	19.58	25	7348	23442	79713573
Joint dislocation	37.73	19.58	22	7351	16917	79720098
Anaemia	36.70	19.58	107	7266	444908	79292107
Cardiovascular disorder	36.46	19.58	22	7351	18003	79719012
Pulmonary hypertension	35.66	19.58	32	7341	48048	79688967
Haematuria	34.56	19.58	37	7336	68799	79668216
Aplastic anaemia	34.03	19.58	21	7352	17884	79719131
Left ventricular dysfunction	32.52	19.58	21	7352	19340	79717675
Tricuspid valve incompetence	32.18	19.58	21	7352	19691	79717324
Oligohydramnios	31.99	19.58	12	7361	3400	79733615
Pulmonary embolism	31.87	19.58	57	7316	171597	79565418
Suture rupture	31.79	19.58	8	7365	595	79736420
Mitral valve incompetence	31.64	19.58	24	7349	28541	79708474
COVID-19 pneumonia	31.43	19.58	24	7349	28825	79708190
Osteopenia	31.05	19.58	20	7353	18344	79718671
Anuria	31.00	19.58	21	7352	20942	79716073
Erysipelas	29.33	19.58	16	7357	10834	79726181
Hiatus hernia	28.99	19.58	21	7352	23291	79713724
Urinary retention	25.92	19.58	29	7344	56601	79680414
SARS-CoV-2 sepsis	24.94	19.58	5	7368	131	79736884
Respiratory failure	24.94	19.58	53	7320	180858	79556157
Thrombocytopenia	23.98	19.58	66	7307	265193	79471822
Premature baby	23.89	19.58	10	7363	3770	79733245
Lymphocele	23.69	19.58	8	7365	1673	79735342
Myelodysplastic syndrome	22.13	19.58	20	7353	30281	79706734
Acetabulum fracture	21.93	19.58	6	7367	618	79736397
Hypertrichosis	21.67	19.58	7	7366	1275	79735740
Conjunctivitis viral	21.66	19.58	5	7368	258	79736757
Paternal exposure during pregnancy	21.49	19.58	4	7369	70	79736945
Cytokine release syndrome	21.03	19.58	21	7352	35977	79701038
Embolic pneumonia	20.71	19.58	4	7369	86	79736929
Hyponatraemic syndrome	20.60	19.58	6	7367	774	79736241
Pain	20.45	19.58	21	7352	703781	79033234
Viral uveitis	20.13	19.58	4	7369	100	79736915
Pyrexia	20.12	19.58	119	7254	678590	79058425
Cardiogenic shock	20.10	19.58	22	7351	41892	79695123
Cardiac failure	19.78	19.58	44	7329	154798	79582217

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	B01AB06	BLOOD AND BLOOD FORMING ORGANS ANTITHROMBOTIC AGENTS ANTITHROMBOTIC AGENTS Heparin group
MeSH PA	D000925	Anticoagulants
MeSH PA	D002317	Cardiovascular Agents
MeSH PA	D005343	Fibrinolytic Agents
MeSH PA	D006401	Hematologic Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Deep venous thrombosis	indication	128053003

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

ID	Source
LIA7Z4002P	UNII
C0206232	UMLSCUI
CHEMBL2109204	ChEMBL_ID
5750	INN_ID
DB08813	DRUGBANK_ID
67031	RXNORM
005821	NDDF
005822	NDDF
698278006	SNOMEDCT_US
699946002	SNOMEDCT_US
773473005	SNOMEDCT_US
D017762	MESH_DESCRIPTOR_UI
9005-49-6	SECONDARY_CAS_RN
772	PUBCHEM_CID

Pharmaceutical products:

None