| Stem definition | Drug id | CAS RN |
|---|---|---|
| erythropoietin type blood factors | 5157 | 209810-58-2 |
| Molecule | Description |
|---|---|
|
Synonyms:
|
acts exactly like the natural erythropoietin made by the body to stimulate red blood cell production, but it is very slightly different in its structure
|
| Dose | Unit | Route |
|---|---|---|
| 4.50 | mcg | P |
None
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Sept. 17, 2001 | FDA | AMGEN |
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Death | 11037.94 | 13.09 | 5174 | 37339 | 369207 | 63077302 |
| Hospitalisation | 4459.77 | 13.09 | 1786 | 40727 | 83295 | 63363214 |
| Investigation | 1179.90 | 13.09 | 262 | 42251 | 1343 | 63445166 |
| Haemodialysis | 1077.00 | 13.09 | 349 | 42164 | 8598 | 63437911 |
| Aplasia pure red cell | 1034.63 | 13.09 | 289 | 42224 | 4198 | 63442311 |
| Transplant | 524.99 | 13.09 | 119 | 42394 | 679 | 63445830 |
| Arteriovenous fistula site complication | 484.90 | 13.09 | 103 | 42410 | 410 | 63446099 |
| Dialysis | 458.35 | 13.09 | 194 | 42319 | 10233 | 63436276 |
| Haemoglobin decreased | 328.30 | 13.09 | 444 | 42069 | 145041 | 63301468 |
| Anaemia | 254.83 | 13.09 | 588 | 41925 | 292842 | 63153667 |
| Shunt stenosis | 247.10 | 13.09 | 60 | 42453 | 480 | 63446029 |
| Terminal state | 246.19 | 13.09 | 82 | 42431 | 2200 | 63444309 |
| Drug ineffective | 231.34 | 13.09 | 217 | 42296 | 1044548 | 62401961 |
| Shunt occlusion | 224.91 | 13.09 | 58 | 42455 | 607 | 63445902 |
| Peritoneal dialysis | 216.06 | 13.09 | 52 | 42461 | 399 | 63446110 |
| Renal disorder | 195.25 | 13.09 | 168 | 42345 | 32806 | 63413703 |
| Renal transplant | 191.36 | 13.09 | 60 | 42453 | 1320 | 63445189 |
| Haemoglobin abnormal | 172.82 | 13.09 | 79 | 42434 | 5009 | 63441500 |
| Therapeutic response decreased | 138.85 | 13.09 | 188 | 42325 | 61337 | 63385172 |
| Rheumatoid arthritis | 137.82 | 13.09 | 8 | 42505 | 253811 | 63192698 |
| Palliative care | 133.48 | 13.09 | 37 | 42476 | 520 | 63445989 |
| Anti-erythropoietin antibody positive | 129.81 | 13.09 | 34 | 42479 | 380 | 63446129 |
| Drug intolerance | 129.27 | 13.09 | 25 | 42488 | 308636 | 63137873 |
| Renal impairment | 121.87 | 13.09 | 215 | 42298 | 88140 | 63358369 |
| Renal failure | 115.51 | 13.09 | 248 | 42265 | 117404 | 63329105 |
| Infusion related reaction | 111.39 | 13.09 | 16 | 42497 | 245505 | 63201004 |
| Joint swelling | 110.01 | 13.09 | 41 | 42472 | 327625 | 63118884 |
| Headache | 107.94 | 13.09 | 161 | 42352 | 633080 | 62813429 |
| Condition aggravated | 106.84 | 13.09 | 69 | 42444 | 402148 | 63044361 |
| Arthropathy | 104.89 | 13.09 | 16 | 42497 | 234776 | 63211733 |
| Drug hypersensitivity | 104.08 | 13.09 | 39 | 42474 | 310648 | 63135861 |
| Product use issue | 103.29 | 13.09 | 13 | 42500 | 220507 | 63226002 |
| Peritonitis | 100.71 | 13.09 | 87 | 42426 | 17067 | 63429442 |
| Arthralgia | 99.83 | 13.09 | 142 | 42371 | 569568 | 62876941 |
| Transfusion | 99.25 | 13.09 | 82 | 42431 | 15135 | 63431374 |
| Arteriovenous fistula operation | 96.62 | 13.09 | 24 | 42489 | 213 | 63446296 |
| Alopecia | 95.06 | 13.09 | 54 | 42459 | 337482 | 63109027 |
| Systemic lupus erythematosus | 91.59 | 13.09 | 15 | 42498 | 208903 | 63237606 |
| Abdominal discomfort | 90.84 | 13.09 | 51 | 42462 | 320834 | 63125675 |
| Cardiac failure | 88.72 | 13.09 | 189 | 42324 | 88953 | 63357556 |
| Pain | 88.51 | 13.09 | 232 | 42281 | 740396 | 62706113 |
| Myelodysplastic syndrome | 88.43 | 13.09 | 80 | 42433 | 16674 | 63429835 |
| Glossodynia | 87.63 | 13.09 | 9 | 42504 | 178867 | 63267642 |
| Hepatic enzyme increased | 85.47 | 13.09 | 16 | 42497 | 202312 | 63244197 |
| Sinusitis | 83.70 | 13.09 | 24 | 42489 | 226629 | 63219880 |
| Haemoglobin increased | 82.81 | 13.09 | 43 | 42470 | 3603 | 63442906 |
| Swelling | 79.03 | 13.09 | 43 | 42470 | 275335 | 63171174 |
| Unevaluable event | 75.99 | 13.09 | 129 | 42384 | 51257 | 63395252 |
| Mineral supplementation | 69.34 | 13.09 | 24 | 42489 | 725 | 63445784 |
| Treatment failure | 68.28 | 13.09 | 24 | 42489 | 199019 | 63247490 |
| Toxicity to various agents | 67.52 | 13.09 | 41 | 42472 | 247209 | 63199300 |
| Completed suicide | 64.86 | 13.09 | 10 | 42503 | 145663 | 63300846 |
| Weight increased | 64.83 | 13.09 | 48 | 42465 | 260744 | 63185765 |
| Wound | 64.63 | 13.09 | 15 | 42498 | 163248 | 63283261 |
| Nephrogenic systemic fibrosis | 63.45 | 13.09 | 39 | 42474 | 4517 | 63441992 |
| Musculoskeletal stiffness | 62.06 | 13.09 | 23 | 42490 | 184595 | 63261914 |
| Hip fracture | 61.85 | 13.09 | 87 | 42426 | 29387 | 63417122 |
| Azotaemia | 61.57 | 13.09 | 38 | 42475 | 4433 | 63442076 |
| Thrombocytopenia | 60.20 | 13.09 | 230 | 42283 | 150927 | 63295582 |
| Therapeutic product effect decreased | 60.18 | 13.09 | 27 | 42486 | 193160 | 63253349 |
| Rehabilitation therapy | 57.23 | 13.09 | 26 | 42487 | 1624 | 63444885 |
| Refractory cytopenia with unilineage dysplasia | 56.23 | 13.09 | 19 | 42494 | 533 | 63445976 |
| Discomfort | 56.01 | 13.09 | 21 | 42492 | 167353 | 63279156 |
| Hypersensitivity | 55.14 | 13.09 | 69 | 42444 | 292616 | 63153893 |
| Occupational exposure to product | 54.47 | 13.09 | 27 | 42486 | 2051 | 63444458 |
| Nasopharyngitis | 53.26 | 13.09 | 55 | 42458 | 254202 | 63192307 |
| Reticulocyte count decreased | 51.17 | 13.09 | 17 | 42496 | 452 | 63446057 |
| Cardiac output decreased | 49.16 | 13.09 | 20 | 42493 | 952 | 63445557 |
| Pericarditis | 48.42 | 13.09 | 14 | 42499 | 131565 | 63314944 |
| Hypervolaemia | 48.32 | 13.09 | 76 | 42437 | 28337 | 63418172 |
| Intentional product use issue | 48.19 | 13.09 | 13 | 42500 | 127879 | 63318630 |
| End stage renal disease | 47.72 | 13.09 | 38 | 42475 | 6655 | 63439854 |
| Transformation to acute myeloid leukaemia | 47.44 | 13.09 | 14 | 42499 | 249 | 63446260 |
| Chronic kidney disease | 47.17 | 13.09 | 98 | 42415 | 45300 | 63401209 |
| Product storage error | 47.02 | 13.09 | 54 | 42459 | 14902 | 63431607 |
| Psoriasis | 46.37 | 13.09 | 3 | 42510 | 86954 | 63359555 |
| Pleural effusion | 45.80 | 13.09 | 152 | 42361 | 93058 | 63353451 |
| Blood cholesterol increased | 45.34 | 13.09 | 5 | 42508 | 94027 | 63352482 |
| Fall | 44.92 | 13.09 | 430 | 42083 | 391904 | 63054605 |
| Duodenal ulcer perforation | 43.71 | 13.09 | 4 | 42509 | 87205 | 63359304 |
| Peripheral swelling | 42.86 | 13.09 | 70 | 42443 | 265872 | 63180637 |
| Shunt infection | 42.47 | 13.09 | 10 | 42503 | 69 | 63446440 |
| Fibromyalgia | 42.22 | 13.09 | 3 | 42510 | 80417 | 63366092 |
| Rash | 41.51 | 13.09 | 214 | 42299 | 560657 | 62885852 |
| Haemodialysis complication | 41.06 | 13.09 | 12 | 42501 | 206 | 63446303 |
| Arteriovenous fistula site infection | 40.69 | 13.09 | 9 | 42504 | 45 | 63446464 |
| Sepsis | 40.38 | 13.09 | 206 | 42307 | 152917 | 63293592 |
| Leukopenia | 39.73 | 13.09 | 128 | 42385 | 77162 | 63369347 |
| Urinary tract infection | 39.65 | 13.09 | 308 | 42205 | 264376 | 63182133 |
| Hepatic cyst infection | 39.01 | 13.09 | 10 | 42503 | 102 | 63446407 |
| Injection site erythema | 38.67 | 13.09 | 5 | 42508 | 83169 | 63363340 |
| Pancytopenia | 38.16 | 13.09 | 147 | 42366 | 96786 | 63349723 |
| Therapeutic product effect incomplete | 38.12 | 13.09 | 18 | 42495 | 125038 | 63321471 |
| Living in residential institution | 37.55 | 13.09 | 14 | 42499 | 526 | 63445983 |
| Anti-erythropoietin antibody negative | 37.38 | 13.09 | 10 | 42503 | 122 | 63446387 |
| Blood parathyroid hormone increased | 37.27 | 13.09 | 24 | 42489 | 3014 | 63443495 |
| Cardiac disorder | 36.61 | 13.09 | 95 | 42418 | 50721 | 63395788 |
| Product use in unapproved indication | 36.07 | 13.09 | 40 | 42473 | 179040 | 63267469 |
| Pneumonia | 35.96 | 13.09 | 465 | 42048 | 456302 | 62990207 |
| Irritable bowel syndrome | 35.90 | 13.09 | 6 | 42507 | 82406 | 63364103 |
| Drug specific antibody absent | 35.63 | 13.09 | 9 | 42504 | 86 | 63446423 |
| Plasma cell myeloma | 35.54 | 13.09 | 76 | 42437 | 35829 | 63410680 |
| Disease progression | 35.09 | 13.09 | 169 | 42344 | 122589 | 63323920 |
| Reticulocyte count abnormal | 34.39 | 13.09 | 8 | 42505 | 52 | 63446457 |
| Renal cyst infection | 32.84 | 13.09 | 9 | 42504 | 121 | 63446388 |
| Bone marrow failure | 32.52 | 13.09 | 65 | 42448 | 29225 | 63417284 |
| Nausea | 32.31 | 13.09 | 392 | 42121 | 854079 | 62592430 |
| Sleep disorder | 31.28 | 13.09 | 8 | 42505 | 81558 | 63364951 |
| Suicidal ideation | 30.91 | 13.09 | 3 | 42510 | 62418 | 63384091 |
| Folliculitis | 30.89 | 13.09 | 5 | 42508 | 70312 | 63376197 |
| Arthritis | 30.54 | 13.09 | 20 | 42493 | 115901 | 63330608 |
| Migraine | 29.80 | 13.09 | 16 | 42497 | 103330 | 63343179 |
| Serum ferritin increased | 29.67 | 13.09 | 28 | 42485 | 6154 | 63440355 |
| Blood creatinine increased | 29.63 | 13.09 | 127 | 42386 | 87717 | 63358792 |
| Dizziness | 29.57 | 13.09 | 168 | 42345 | 429757 | 63016752 |
| Iron deficiency | 29.57 | 13.09 | 30 | 42483 | 7200 | 63439309 |
| Drug interaction | 29.37 | 13.09 | 69 | 42444 | 229062 | 63217447 |
| Anti-erythropoietin antibody | 29.20 | 13.09 | 5 | 42508 | 3 | 63446506 |
| Premature delivery | 27.59 | 13.09 | 62 | 42451 | 30219 | 63416290 |
| Asthma | 27.36 | 13.09 | 27 | 42486 | 127534 | 63318975 |
| Diabetic complication | 27.35 | 13.09 | 13 | 42500 | 900 | 63445609 |
| Fungal endocarditis | 27.28 | 13.09 | 9 | 42504 | 234 | 63446275 |
| Liver injury | 27.28 | 13.09 | 4 | 42509 | 60516 | 63385993 |
| Marasmus | 27.23 | 13.09 | 11 | 42502 | 514 | 63445995 |
| Somnolence | 26.96 | 13.09 | 49 | 42464 | 178636 | 63267873 |
| Depression | 26.96 | 13.09 | 57 | 42456 | 196435 | 63250074 |
| Intercepted product administration error | 26.72 | 13.09 | 10 | 42503 | 380 | 63446129 |
| Blister | 26.13 | 13.09 | 29 | 42484 | 129785 | 63316724 |
| Neoplasm malignant | 25.95 | 13.09 | 60 | 42453 | 29801 | 63416708 |
| Product dose omission issue | 25.89 | 13.09 | 76 | 42437 | 234237 | 63212272 |
| Transplant failure | 25.79 | 13.09 | 15 | 42498 | 1570 | 63444939 |
| Gastrointestinal disorder | 25.68 | 13.09 | 30 | 42483 | 131209 | 63315300 |
| Loss of personal independence in daily activities | 25.34 | 13.09 | 17 | 42496 | 97273 | 63349236 |
| Home care | 25.24 | 13.09 | 4 | 42509 | 0 | 63446509 |
| Skin induration | 24.49 | 13.09 | 19 | 42494 | 3204 | 63443305 |
| Cellulitis | 24.26 | 13.09 | 114 | 42399 | 81844 | 63364665 |
| Impaired healing | 24.02 | 13.09 | 20 | 42493 | 102522 | 63343987 |
| Arteriovenous fistula thrombosis | 23.86 | 13.09 | 8 | 42505 | 219 | 63446290 |
| Kidney transplant rejection | 23.73 | 13.09 | 21 | 42492 | 4250 | 63442259 |
| Memory impairment | 23.61 | 13.09 | 21 | 42492 | 104237 | 63342272 |
| Knee arthroplasty | 23.49 | 13.09 | 4 | 42509 | 54202 | 63392307 |
| Type 2 diabetes mellitus | 23.11 | 13.09 | 7 | 42506 | 63861 | 63382648 |
| Hyperkalaemia | 22.81 | 13.09 | 84 | 42429 | 54119 | 63392390 |
| Infective aneurysm | 22.71 | 13.09 | 9 | 42504 | 400 | 63446109 |
| Illness | 22.68 | 13.09 | 3 | 42510 | 49056 | 63397453 |
| Angina pectoris | 22.45 | 13.09 | 57 | 42456 | 30021 | 63416488 |
| Haemolysis | 22.23 | 13.09 | 25 | 42488 | 6743 | 63439766 |
| Myelodysplastic syndrome transformation | 22.15 | 13.09 | 9 | 42504 | 427 | 63446082 |
| Blood potassium increased | 21.99 | 13.09 | 42 | 42471 | 18267 | 63428242 |
| Iron overload | 21.66 | 13.09 | 11 | 42502 | 880 | 63445629 |
| Leg amputation | 21.51 | 13.09 | 15 | 42498 | 2149 | 63444360 |
| Epistaxis | 21.41 | 13.09 | 101 | 42412 | 72624 | 63373885 |
| Hyperphosphataemia | 20.99 | 13.09 | 15 | 42498 | 2233 | 63444276 |
| Nasal congestion | 20.71 | 13.09 | 9 | 42504 | 65651 | 63380858 |
| Exposure during pregnancy | 20.60 | 13.09 | 46 | 42467 | 155501 | 63291008 |
| Maternal condition affecting foetus | 20.56 | 13.09 | 7 | 42506 | 201 | 63446308 |
| Neutropenia | 20.55 | 13.09 | 193 | 42320 | 174812 | 63271697 |
| Hypocalcaemia | 20.53 | 13.09 | 57 | 42456 | 31656 | 63414853 |
| Visual impairment | 20.37 | 13.09 | 16 | 42497 | 84430 | 63362079 |
| Injection site pruritus | 20.29 | 13.09 | 3 | 42510 | 45113 | 63401396 |
| Renal transplant failure | 20.27 | 13.09 | 10 | 42503 | 752 | 63445757 |
| Insomnia | 20.20 | 13.09 | 75 | 42438 | 215177 | 63231332 |
| Eye infection bacterial | 20.11 | 13.09 | 7 | 42506 | 215 | 63446294 |
| Blood erythropoietin increased | 19.96 | 13.09 | 4 | 42509 | 11 | 63446498 |
| Pain in extremity | 19.93 | 13.09 | 135 | 42378 | 331351 | 63115158 |
| Oedema peripheral | 19.81 | 13.09 | 204 | 42309 | 189307 | 63257202 |
| Osteoarthritis | 19.51 | 13.09 | 21 | 42492 | 95322 | 63351187 |
| Extramedullary haemopoiesis | 19.33 | 13.09 | 5 | 42508 | 53 | 63446456 |
| Dehydration | 19.27 | 13.09 | 189 | 42324 | 173165 | 63273344 |
| Maternal exposure during pregnancy | 19.16 | 13.09 | 79 | 42434 | 219983 | 63226526 |
| Hyperparathyroidism secondary | 19.02 | 13.09 | 12 | 42501 | 1455 | 63445054 |
| Natural killer cell count | 18.81 | 13.09 | 4 | 42509 | 16 | 63446493 |
| Amegakaryocytic thrombocytopenia | 18.81 | 13.09 | 4 | 42509 | 16 | 63446493 |
| Anxiety | 18.38 | 13.09 | 79 | 42434 | 217462 | 63229047 |
| Urine odour abnormal | 18.31 | 13.09 | 22 | 42491 | 6367 | 63440142 |
| Parakeratosis | 18.17 | 13.09 | 7 | 42506 | 288 | 63446221 |
| Device related infection | 18.16 | 13.09 | 45 | 42468 | 23347 | 63423162 |
| Marrow hyperplasia | 18.09 | 13.09 | 9 | 42504 | 689 | 63445820 |
| Ischaemic stroke | 17.76 | 13.09 | 38 | 42475 | 17919 | 63428590 |
| Hypertension | 17.75 | 13.09 | 274 | 42239 | 279029 | 63167480 |
| Dialysis related complication | 17.74 | 13.09 | 5 | 42508 | 75 | 63446434 |
| Dry eye | 17.68 | 13.09 | 3 | 42510 | 40758 | 63405751 |
| Macrophages increased | 17.62 | 13.09 | 4 | 42509 | 23 | 63446486 |
| Skin hypertrophy | 17.51 | 13.09 | 16 | 42497 | 3375 | 63443134 |
| Proteinuria | 17.22 | 13.09 | 39 | 42474 | 19106 | 63427403 |
| Gait disturbance | 17.07 | 13.09 | 64 | 42449 | 183114 | 63263395 |
| Blood product transfusion dependent | 17.07 | 13.09 | 6 | 42507 | 190 | 63446319 |
| Adverse drug reaction | 16.94 | 13.09 | 17 | 42496 | 79697 | 63366812 |
| Deep vein thrombosis | 16.93 | 13.09 | 105 | 42408 | 83695 | 63362814 |
| Cerebrovascular accident | 16.86 | 13.09 | 127 | 42386 | 107897 | 63338612 |
| Uterine atony | 16.83 | 13.09 | 6 | 42507 | 198 | 63446311 |
| Medication error | 16.75 | 13.09 | 7 | 42506 | 52277 | 63394232 |
| Arteriovenous fistula site haemorrhage | 16.63 | 13.09 | 6 | 42507 | 205 | 63446304 |
| Acute myeloid leukaemia | 16.63 | 13.09 | 36 | 42477 | 17111 | 63429398 |
| Intermittent claudication | 16.55 | 13.09 | 12 | 42501 | 1827 | 63444682 |
| Cerebral infarction | 16.52 | 13.09 | 44 | 42469 | 23849 | 63422660 |
| Arteriovenous fistula occlusion | 16.48 | 13.09 | 7 | 42506 | 372 | 63446137 |
| Cardiac failure congestive | 16.35 | 13.09 | 112 | 42401 | 92321 | 63354188 |
| Skin fibrosis | 16.13 | 13.09 | 9 | 42504 | 871 | 63445638 |
| Dry mouth | 16.10 | 13.09 | 17 | 42496 | 77846 | 63368663 |
| Serum ferritin abnormal | 15.86 | 13.09 | 6 | 42507 | 235 | 63446274 |
| Fatigue | 15.74 | 13.09 | 464 | 42049 | 887564 | 62558945 |
| Fracture | 15.55 | 13.09 | 38 | 42475 | 19546 | 63426963 |
| Hepatotoxicity | 15.47 | 13.09 | 3 | 42510 | 37038 | 63409471 |
| Urticaria | 15.40 | 13.09 | 58 | 42455 | 165744 | 63280765 |
| Neutralising antibodies positive | 15.30 | 13.09 | 6 | 42507 | 259 | 63446250 |
| Calciphylaxis | 14.91 | 13.09 | 14 | 42499 | 3058 | 63443451 |
| Nephrogenic anaemia | 14.83 | 13.09 | 12 | 42501 | 2150 | 63444359 |
| Peripheral arterial occlusive disease | 14.63 | 13.09 | 16 | 42497 | 4185 | 63442324 |
| Hyperuricaemia | 14.59 | 13.09 | 18 | 42495 | 5352 | 63441157 |
| Cardiac arrest | 14.55 | 13.09 | 109 | 42404 | 92436 | 63354073 |
| Peritonitis bacterial | 14.31 | 13.09 | 17 | 42496 | 4862 | 63441647 |
| Blood test abnormal | 14.24 | 13.09 | 32 | 42481 | 15597 | 63430912 |
| Myocardial infarction | 14.23 | 13.09 | 115 | 42398 | 99778 | 63346731 |
| Mycobacterial peritonitis | 14.13 | 13.09 | 4 | 42509 | 61 | 63446448 |
| Platelet count decreased | 14.09 | 13.09 | 129 | 42384 | 115993 | 63330516 |
| Abortion spontaneous | 14.06 | 13.09 | 7 | 42506 | 47188 | 63399321 |
| Haemorrhage | 13.96 | 13.09 | 79 | 42434 | 60943 | 63385566 |
| Renal lymphocele | 13.83 | 13.09 | 4 | 42509 | 66 | 63446443 |
| Eyelid oedema | 13.79 | 13.09 | 25 | 42488 | 10454 | 63436055 |
| Prescribed overdose | 13.78 | 13.09 | 3 | 42510 | 34150 | 63412359 |
| Hypoaesthesia | 13.71 | 13.09 | 62 | 42451 | 168331 | 63278178 |
| Agitation | 13.57 | 13.09 | 12 | 42501 | 59745 | 63386764 |
| Bursitis | 13.51 | 13.09 | 4 | 42509 | 37037 | 63409472 |
| Shunt thrombosis | 13.46 | 13.09 | 4 | 42509 | 73 | 63446436 |
| Peritoneal dialysis complication | 13.41 | 13.09 | 9 | 42504 | 1211 | 63445298 |
| Vascular shunt | 13.40 | 13.09 | 3 | 42510 | 16 | 63446493 |
| Thrombosis in device | 13.32 | 13.09 | 13 | 42500 | 2977 | 63443532 |
| Off label use | 13.32 | 13.09 | 565 | 41948 | 673897 | 62772612 |
| Pulmonary fibrosis | 13.29 | 13.09 | 5 | 42508 | 39804 | 63406705 |
| Upper limb fracture | 13.19 | 13.09 | 35 | 42478 | 18933 | 63427576 |
| Polycythaemia | 13.17 | 13.09 | 8 | 42505 | 907 | 63445602 |
| Gastric antral vascular ectasia | 13.12 | 13.09 | 7 | 42506 | 620 | 63445889 |
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Death | 12058.00 | 13.62 | 7154 | 42312 | 390895 | 34516570 |
| Hospitalisation | 4660.53 | 13.62 | 2036 | 47430 | 54866 | 34852599 |
| Aplasia pure red cell | 1258.81 | 13.62 | 430 | 49036 | 5702 | 34901763 |
| Haemodialysis | 1056.29 | 13.62 | 437 | 49029 | 10089 | 34897376 |
| Investigation | 877.33 | 13.62 | 214 | 49252 | 716 | 34906749 |
| Arteriovenous fistula site complication | 702.78 | 13.62 | 157 | 49309 | 310 | 34907155 |
| Dialysis | 439.33 | 13.62 | 244 | 49222 | 10964 | 34896501 |
| Transplant | 432.46 | 13.62 | 119 | 49347 | 707 | 34906758 |
| Shunt stenosis | 272.22 | 13.62 | 82 | 49384 | 700 | 34906765 |
| Peritoneal dialysis | 270.73 | 13.62 | 77 | 49389 | 525 | 34906940 |
| Haemoglobin decreased | 243.21 | 13.62 | 531 | 48935 | 120241 | 34787224 |
| Haemoglobin abnormal | 240.43 | 13.62 | 115 | 49351 | 3765 | 34903700 |
| Appendicolith | 234.09 | 13.62 | 148 | 49318 | 8453 | 34899012 |
| Anti-erythropoietin antibody positive | 200.20 | 13.62 | 67 | 49399 | 828 | 34906637 |
| Appendicitis | 168.35 | 13.62 | 151 | 49315 | 14656 | 34892809 |
| Renal disorder | 167.09 | 13.62 | 193 | 49273 | 25287 | 34882178 |
| Shunt occlusion | 162.87 | 13.62 | 57 | 49409 | 813 | 34906652 |
| Terminal state | 155.06 | 13.62 | 86 | 49380 | 3848 | 34903617 |
| Therapeutic response decreased | 154.78 | 13.62 | 199 | 49267 | 29114 | 34878351 |
| Toxicity to various agents | 142.18 | 13.62 | 53 | 49413 | 200309 | 34707156 |
| Transfusion | 131.54 | 13.62 | 104 | 49362 | 8481 | 34898984 |
| Cardiogenic shock | 113.62 | 13.62 | 163 | 49303 | 26455 | 34881010 |
| Drug ineffective | 113.47 | 13.62 | 305 | 49161 | 456446 | 34451019 |
| Renal transplant | 109.09 | 13.62 | 53 | 49413 | 1796 | 34905669 |
| Arteriovenous fistula operation | 103.88 | 13.62 | 27 | 49439 | 124 | 34907341 |
| Palliative care | 100.55 | 13.62 | 38 | 49428 | 682 | 34906783 |
| Drug interaction | 100.53 | 13.62 | 103 | 49363 | 225843 | 34681622 |
| Blood phosphorus increased | 98.32 | 13.62 | 84 | 49382 | 7637 | 34899828 |
| Reticulocyte count decreased | 94.45 | 13.62 | 36 | 49430 | 662 | 34906803 |
| Stress | 89.61 | 13.62 | 157 | 49309 | 30190 | 34877275 |
| Ascites | 84.80 | 13.62 | 197 | 49269 | 46374 | 34861091 |
| Transformation to acute myeloid leukaemia | 83.91 | 13.62 | 34 | 49432 | 740 | 34906725 |
| Product use in unapproved indication | 81.72 | 13.62 | 32 | 49434 | 117467 | 34789998 |
| Haemoglobin increased | 76.49 | 13.62 | 52 | 49414 | 3357 | 34904108 |
| Myelodysplastic syndrome | 73.85 | 13.62 | 112 | 49354 | 19096 | 34888369 |
| Hip fracture | 70.98 | 13.62 | 86 | 49380 | 11839 | 34895626 |
| Peritonitis | 70.97 | 13.62 | 101 | 49365 | 16264 | 34891201 |
| Anaemia | 69.80 | 13.62 | 566 | 48900 | 232769 | 34674696 |
| Ventricular fibrillation | 66.78 | 13.62 | 118 | 49348 | 22836 | 34884629 |
| Hyperparathyroidism secondary | 63.77 | 13.62 | 35 | 49431 | 1533 | 34905932 |
| Chronic kidney disease | 62.97 | 13.62 | 163 | 49303 | 41047 | 34866418 |
| Product storage error | 62.64 | 13.62 | 67 | 49399 | 8055 | 34899410 |
| Lower respiratory tract infection | 62.21 | 13.62 | 138 | 49328 | 31499 | 34875966 |
| Sepsis | 61.03 | 13.62 | 424 | 49042 | 166137 | 34741328 |
| Neoplasm malignant | 60.08 | 13.62 | 104 | 49362 | 19801 | 34887664 |
| Product use issue | 59.85 | 13.62 | 9 | 49457 | 63207 | 34844258 |
| Mineral supplementation | 59.79 | 13.62 | 16 | 49450 | 84 | 34907381 |
| Renal cyst haemorrhage | 58.90 | 13.62 | 25 | 49441 | 614 | 34906851 |
| Rectal prolapse | 58.15 | 13.62 | 23 | 49443 | 469 | 34906996 |
| Nephrogenic systemic fibrosis | 58.11 | 13.62 | 47 | 49419 | 3958 | 34903507 |
| Intentional product use issue | 57.83 | 13.62 | 8 | 49458 | 59808 | 34847657 |
| Headache | 56.62 | 13.62 | 125 | 49341 | 200510 | 34706955 |
| Azotaemia | 55.15 | 13.62 | 50 | 49416 | 4917 | 34902548 |
| Multiple organ dysfunction syndrome | 54.69 | 13.62 | 234 | 49232 | 76332 | 34831133 |
| Arthralgia | 53.90 | 13.62 | 99 | 49367 | 169942 | 34737523 |
| Intraductal papillary mucinous neoplasm | 52.89 | 13.62 | 22 | 49444 | 513 | 34906952 |
| Living in residential institution | 52.74 | 13.62 | 21 | 49445 | 436 | 34907029 |
| Abdominal distension | 50.77 | 13.62 | 190 | 49276 | 58302 | 34849163 |
| Product dose omission issue | 49.36 | 13.62 | 58 | 49408 | 119653 | 34787812 |
| Arteriovenous fistula site infection | 47.85 | 13.62 | 13 | 49453 | 73 | 34907392 |
| Arteriovenous fistula thrombosis | 47.53 | 13.62 | 18 | 49448 | 325 | 34907140 |
| Renal artery stenosis | 47.22 | 13.62 | 33 | 49433 | 2228 | 34905237 |
| Alanine aminotransferase increased | 47.03 | 13.62 | 28 | 49438 | 80787 | 34826678 |
| Delayed graft function | 45.41 | 13.62 | 32 | 49434 | 2189 | 34905276 |
| Suicidal ideation | 45.34 | 13.62 | 3 | 49463 | 40385 | 34867080 |
| Weight increased | 45.29 | 13.62 | 39 | 49427 | 92994 | 34814471 |
| Unevaluable event | 43.84 | 13.62 | 123 | 49343 | 32467 | 34874998 |
| Aggression | 43.43 | 13.62 | 3 | 49463 | 38961 | 34868504 |
| Hyperhidrosis | 42.97 | 13.62 | 27 | 49439 | 75665 | 34831800 |
| Vena cava injury | 40.55 | 13.62 | 16 | 49450 | 324 | 34907141 |
| SARS-CoV-2 antibody test positive | 40.45 | 13.62 | 17 | 49449 | 407 | 34907058 |
| Hyperphosphataemia | 40.36 | 13.62 | 40 | 49426 | 4397 | 34903068 |
| Depression | 40.06 | 13.62 | 47 | 49419 | 97051 | 34810414 |
| Angina pectoris | 39.88 | 13.62 | 116 | 49350 | 31247 | 34876218 |
| Refractory cytopenia with unilineage dysplasia | 39.35 | 13.62 | 18 | 49448 | 531 | 34906934 |
| Treatment failure | 39.17 | 13.62 | 9 | 49457 | 46688 | 34860777 |
| Joint swelling | 38.91 | 13.62 | 18 | 49448 | 59872 | 34847593 |
| Abdominal wall haemorrhage | 38.09 | 13.62 | 17 | 49449 | 473 | 34906992 |
| Zoonotic bacterial infection | 37.94 | 13.62 | 10 | 49456 | 49 | 34907416 |
| Hallucination | 37.50 | 13.62 | 13 | 49453 | 51485 | 34855980 |
| Rehabilitation therapy | 36.73 | 13.62 | 20 | 49446 | 862 | 34906603 |
| Vascular anastomotic haemorrhage | 35.97 | 13.62 | 14 | 49452 | 273 | 34907192 |
| Infusion related reaction | 35.96 | 13.62 | 15 | 49451 | 53042 | 34854423 |
| Hypervolaemia | 35.44 | 13.62 | 83 | 49383 | 19626 | 34887839 |
| Leg amputation | 34.40 | 13.62 | 27 | 49439 | 2177 | 34905288 |
| Intermittent claudication | 33.45 | 13.62 | 27 | 49439 | 2267 | 34905198 |
| Home care | 33.37 | 13.62 | 6 | 49460 | 0 | 34907465 |
| Agitation | 33.23 | 13.62 | 20 | 49446 | 57379 | 34850086 |
| Perineal cyst | 33.14 | 13.62 | 13 | 49453 | 259 | 34907206 |
| Dizziness | 33.09 | 13.62 | 178 | 49288 | 218343 | 34689122 |
| Sinusitis | 32.75 | 13.62 | 9 | 49457 | 41393 | 34866072 |
| Erythropoiesis abnormal | 32.14 | 13.62 | 12 | 49454 | 208 | 34907257 |
| Tachycardia | 31.89 | 13.62 | 44 | 49422 | 84728 | 34822737 |
| Urinary tract infection | 31.88 | 13.62 | 216 | 49250 | 83865 | 34823600 |
| General physical health deterioration | 31.39 | 13.62 | 298 | 49168 | 127971 | 34779494 |
| Blood uric acid increased | 31.30 | 13.62 | 52 | 49414 | 9572 | 34897893 |
| Aspartate aminotransferase increased | 31.09 | 13.62 | 30 | 49436 | 67753 | 34839712 |
| Rheumatoid arthritis | 30.84 | 13.62 | 8 | 49458 | 38230 | 34869235 |
| Iron deficiency | 30.71 | 13.62 | 38 | 49428 | 5343 | 34902122 |
| Normochromic normocytic anaemia | 30.68 | 13.62 | 34 | 49432 | 4253 | 34903212 |
| Rash | 30.22 | 13.62 | 188 | 49278 | 222564 | 34684901 |
| Drug-induced liver injury | 29.98 | 13.62 | 3 | 49463 | 28829 | 34878636 |
| Hepatic enzyme increased | 29.98 | 13.62 | 9 | 49457 | 39071 | 34868394 |
| Peripheral arterial occlusive disease | 29.61 | 13.62 | 39 | 49427 | 5835 | 34901630 |
| Carotid arteriosclerosis | 29.52 | 13.62 | 23 | 49443 | 1835 | 34905630 |
| Rhabdomyolysis | 29.19 | 13.62 | 32 | 49434 | 68131 | 34839334 |
| Vascular compression | 29.08 | 13.62 | 13 | 49453 | 363 | 34907102 |
| Mycobacterium marinum infection | 28.64 | 13.62 | 12 | 49454 | 285 | 34907180 |
| Hepatic cyst infection | 28.12 | 13.62 | 7 | 49459 | 26 | 34907439 |
| Inappropriate schedule of product administration | 28.08 | 13.62 | 28 | 49438 | 62268 | 34845197 |
| Anxiety | 27.95 | 13.62 | 62 | 49404 | 99366 | 34808099 |
| Mean cell volume increased | 27.78 | 13.62 | 28 | 49438 | 3141 | 34904324 |
| Chest discomfort | 27.59 | 13.62 | 22 | 49444 | 54508 | 34852957 |
| Blood iron abnormal | 27.58 | 13.62 | 8 | 49458 | 59 | 34907406 |
| Overdose | 27.09 | 13.62 | 55 | 49411 | 91004 | 34816461 |
| Lactic acidosis | 26.69 | 13.62 | 8 | 49458 | 34764 | 34872701 |
| Reticulocytopenia | 26.47 | 13.62 | 9 | 49457 | 117 | 34907348 |
| Tremor | 26.20 | 13.62 | 48 | 49418 | 82539 | 34824926 |
| Marasmus | 26.13 | 13.62 | 14 | 49452 | 584 | 34906881 |
| Gangrene | 25.55 | 13.62 | 32 | 49434 | 4554 | 34902911 |
| Catheter removal | 25.14 | 13.62 | 10 | 49456 | 207 | 34907258 |
| Respiratory failure | 24.92 | 13.62 | 75 | 49391 | 108497 | 34798968 |
| Non-neutralising antibodies positive | 24.91 | 13.62 | 8 | 49458 | 86 | 34907379 |
| Angioedema | 24.63 | 13.62 | 11 | 49455 | 37363 | 34870102 |
| Myasthenia gravis | 24.61 | 13.62 | 39 | 49427 | 6901 | 34900564 |
| Pyrexia | 24.60 | 13.62 | 328 | 49138 | 332685 | 34574780 |
| Irritability | 24.58 | 13.62 | 3 | 49463 | 24687 | 34882778 |
| Febrile neutropenia | 24.46 | 13.62 | 105 | 49361 | 136744 | 34770721 |
| Interstitial lung disease | 24.43 | 13.62 | 34 | 49432 | 65248 | 34842217 |
| Weight decreased | 24.30 | 13.62 | 148 | 49318 | 176153 | 34731312 |
| Psychotic disorder | 24.28 | 13.62 | 3 | 49463 | 24449 | 34883016 |
| Blood creatine phosphokinase increased | 24.10 | 13.62 | 17 | 49449 | 44840 | 34862625 |
| Angiodysplasia | 24.00 | 13.62 | 14 | 49452 | 690 | 34906775 |
| Renal cyst infection | 23.97 | 13.62 | 7 | 49459 | 53 | 34907412 |
| Complications of transplanted kidney | 23.85 | 13.62 | 31 | 49435 | 4578 | 34902887 |
| Aortic arteriosclerosis | 23.71 | 13.62 | 31 | 49435 | 4605 | 34902860 |
| Aortic dilatation | 23.69 | 13.62 | 18 | 49448 | 1383 | 34906082 |
| Abdominal discomfort | 23.57 | 13.62 | 30 | 49436 | 59805 | 34847660 |
| Hyperparathyroidism | 23.56 | 13.62 | 17 | 49449 | 1207 | 34906258 |
| Shunt aneurysm | 23.55 | 13.62 | 6 | 49460 | 25 | 34907440 |
| Intervertebral disc space narrowing | 23.45 | 13.62 | 16 | 49450 | 1039 | 34906426 |
| Dialysis hypotension | 23.37 | 13.62 | 6 | 49460 | 26 | 34907439 |
| Drug ineffective for unapproved indication | 23.32 | 13.62 | 3 | 49463 | 23712 | 34883753 |
| Cognitive disorder | 23.14 | 13.62 | 6 | 49460 | 28687 | 34878778 |
| Asthma | 23.14 | 13.62 | 16 | 49450 | 42640 | 34864825 |
| Blood 25-hydroxycholecalciferol decreased | 23.07 | 13.62 | 10 | 49456 | 259 | 34907206 |
| Blood potassium increased | 22.91 | 13.62 | 63 | 49403 | 16432 | 34891033 |
| Procalcitonin abnormal | 22.69 | 13.62 | 11 | 49455 | 371 | 34907094 |
| Muscle spasms | 22.56 | 13.62 | 45 | 49421 | 74956 | 34832509 |
| End stage renal disease | 22.54 | 13.62 | 43 | 49423 | 8818 | 34898647 |
| Cardio-respiratory arrest | 22.52 | 13.62 | 27 | 49439 | 55246 | 34852219 |
| Memory impairment | 22.51 | 13.62 | 17 | 49449 | 43301 | 34864164 |
| Peritoneal catheter insertion | 22.25 | 13.62 | 4 | 49462 | 0 | 34907465 |
| Anti-erythropoietin antibody | 22.25 | 13.62 | 4 | 49462 | 0 | 34907465 |
| Musculoskeletal stiffness | 22.18 | 13.62 | 20 | 49446 | 46660 | 34860805 |
| Pain in extremity | 22.04 | 13.62 | 98 | 49368 | 126415 | 34781050 |
| Parvovirus B19 test positive | 21.96 | 13.62 | 8 | 49458 | 129 | 34907336 |
| Analgesic therapy | 21.86 | 13.62 | 15 | 49451 | 983 | 34906482 |
| Acute respiratory distress syndrome | 21.79 | 13.62 | 5 | 49461 | 25964 | 34881501 |
| Disturbance in attention | 21.76 | 13.62 | 5 | 49461 | 25940 | 34881525 |
| Hyponatraemia | 21.66 | 13.62 | 195 | 49271 | 82496 | 34824969 |
| Visual impairment | 21.39 | 13.62 | 12 | 49454 | 35790 | 34871675 |
| Fatigue | 21.28 | 13.62 | 383 | 49083 | 370270 | 34537195 |
| Pleural effusion | 21.21 | 13.62 | 192 | 49274 | 81354 | 34826111 |
| Serum ferritin increased | 21.06 | 13.62 | 34 | 49432 | 6112 | 34901353 |
| Haematochezia | 20.87 | 13.62 | 21 | 49445 | 46513 | 34860952 |
| Cardiac failure | 20.84 | 13.62 | 209 | 49257 | 91039 | 34816426 |
| Depressed level of consciousness | 20.78 | 13.62 | 18 | 49448 | 42823 | 34864642 |
| Mucosal inflammation | 20.27 | 13.62 | 15 | 49451 | 38607 | 34868858 |
| Iron overload | 20.10 | 13.62 | 16 | 49450 | 1317 | 34906148 |
| Transferrin saturation increased | 20.05 | 13.62 | 7 | 49459 | 99 | 34907366 |
| Drug therapy | 20.05 | 13.62 | 15 | 49451 | 1126 | 34906339 |
| Constipation | 19.96 | 13.62 | 288 | 49178 | 136694 | 34770771 |
| Catheter placement | 19.90 | 13.62 | 13 | 49453 | 785 | 34906680 |
| Erectile dysfunction | 19.38 | 13.62 | 3 | 49463 | 20634 | 34886831 |
| Vision blurred | 19.21 | 13.62 | 22 | 49444 | 45941 | 34861524 |
| Diverticulum intestinal | 19.20 | 13.62 | 26 | 49440 | 3995 | 34903470 |
| Coma | 18.95 | 13.62 | 22 | 49444 | 45656 | 34861809 |
| Skin fibrosis | 18.87 | 13.62 | 14 | 49452 | 1038 | 34906427 |
| Skin induration | 18.84 | 13.62 | 19 | 49447 | 2132 | 34905333 |
| Loss of personal independence in daily activities | 18.59 | 13.62 | 12 | 49454 | 33167 | 34874298 |
| Serotonin syndrome | 18.49 | 13.62 | 3 | 49463 | 19930 | 34887535 |
| Hepatosplenomegaly | 18.47 | 13.62 | 26 | 49440 | 4143 | 34903322 |
| Heart rate decreased | 18.46 | 13.62 | 11 | 49455 | 31734 | 34875731 |
| Metastatic neoplasm | 18.44 | 13.62 | 22 | 49444 | 2978 | 34904487 |
| Hepatotoxicity | 18.30 | 13.62 | 4 | 49462 | 21481 | 34885984 |
| Renal transplant failure | 18.24 | 13.62 | 14 | 49452 | 1092 | 34906373 |
| Drug hypersensitivity | 18.20 | 13.62 | 56 | 49410 | 80473 | 34826992 |
| Abdominal pain upper | 18.16 | 13.62 | 47 | 49419 | 71443 | 34836022 |
| Arteriovenous fistula occlusion | 17.96 | 13.62 | 7 | 49459 | 137 | 34907328 |
| Electrocardiogram QT prolonged | 17.78 | 13.62 | 19 | 49447 | 40933 | 34866532 |
| Depressed mood | 17.71 | 13.62 | 3 | 49463 | 19314 | 34888151 |
| Cough | 17.70 | 13.62 | 132 | 49334 | 150008 | 34757457 |
| Hypoaesthesia | 17.52 | 13.62 | 38 | 49428 | 61406 | 34846059 |
| Blood bilirubin increased | 17.50 | 13.62 | 17 | 49449 | 38279 | 34869186 |
| Delirium | 17.38 | 13.62 | 22 | 49444 | 43969 | 34863496 |
| Malignant neoplasm progression | 17.33 | 13.62 | 65 | 49401 | 87981 | 34819484 |
| Gait disturbance | 17.32 | 13.62 | 62 | 49404 | 85078 | 34822387 |
| Feeling abnormal | 17.30 | 13.62 | 40 | 49426 | 63195 | 34844270 |
| Reticulocyte count abnormal | 17.25 | 13.62 | 4 | 49462 | 10 | 34907455 |
| Coronary artery disease | 17.24 | 13.62 | 26 | 49440 | 48279 | 34859186 |
| Insomnia | 17.19 | 13.62 | 82 | 49384 | 103825 | 34803640 |
| Sleep disorder therapy | 16.98 | 13.62 | 13 | 49453 | 1010 | 34906455 |
| Intercepted product administration error | 16.86 | 13.62 | 8 | 49458 | 257 | 34907208 |
| Inadequate osteointegration | 16.72 | 13.62 | 4 | 49462 | 12 | 34907453 |
| Encephalomalacia | 16.71 | 13.62 | 12 | 49454 | 846 | 34906619 |
| Oedema due to renal disease | 16.69 | 13.62 | 3 | 49463 | 0 | 34907465 |
| Myalgia | 16.62 | 13.62 | 62 | 49404 | 84048 | 34823417 |
| Spinal stenosis | 16.51 | 13.62 | 28 | 49438 | 5241 | 34902224 |
| Blood product transfusion dependent | 16.40 | 13.62 | 9 | 49457 | 394 | 34907071 |
| Toe amputation | 16.33 | 13.62 | 19 | 49447 | 2505 | 34904960 |
| Cardiac valve disease | 16.18 | 13.62 | 21 | 49445 | 3097 | 34904368 |
| PCO2 decreased | 16.13 | 13.62 | 16 | 49450 | 1760 | 34905705 |
| Neurotoxicity | 16.07 | 13.62 | 3 | 49463 | 18007 | 34889458 |
| Seizure | 16.06 | 13.62 | 85 | 49381 | 104772 | 34802693 |
| Wheezing | 16.06 | 13.62 | 21 | 49445 | 41381 | 34866084 |
| Swelling of eyelid | 16.04 | 13.62 | 13 | 49453 | 1098 | 34906367 |
| Pain | 16.03 | 13.62 | 199 | 49267 | 204476 | 34702989 |
| Fracture | 15.92 | 13.62 | 32 | 49434 | 6817 | 34900648 |
| Dyspnoea | 15.89 | 13.62 | 409 | 49057 | 376373 | 34531092 |
| Fall | 15.76 | 13.62 | 387 | 49079 | 202498 | 34704967 |
| Arteriovenous fistula site haemorrhage | 15.76 | 13.62 | 6 | 49460 | 110 | 34907355 |
| Dysgeusia | 15.66 | 13.62 | 9 | 49457 | 26488 | 34880977 |
| Therapeutic product effect incomplete | 15.47 | 13.62 | 30 | 49436 | 50511 | 34856954 |
| Abnormal behaviour | 15.46 | 13.62 | 8 | 49458 | 24961 | 34882504 |
| Drug level increased | 15.37 | 13.62 | 6 | 49460 | 22090 | 34885375 |
| Blood glucose increased | 15.36 | 13.62 | 46 | 49420 | 66672 | 34840793 |
| Anti-erythropoietin antibody negative | 15.19 | 13.62 | 7 | 49459 | 210 | 34907255 |
| Foetal exposure during pregnancy | 15.11 | 13.62 | 19 | 49447 | 38082 | 34869383 |
| Sleep apnoea syndrome | 15.01 | 13.62 | 5 | 49461 | 20316 | 34887149 |
| Heart valve operation | 14.92 | 13.62 | 5 | 49461 | 62 | 34907403 |
| Tinnitus | 14.78 | 13.62 | 5 | 49461 | 20113 | 34887352 |
| Hepatic function abnormal | 14.77 | 13.62 | 25 | 49441 | 44338 | 34863127 |
| Oxygen saturation decreased | 14.76 | 13.62 | 34 | 49432 | 53784 | 34853681 |
| Psoriasis | 14.73 | 13.62 | 20 | 49446 | 38792 | 34868673 |
| Benign neoplasm | 14.66 | 13.62 | 7 | 49459 | 228 | 34907237 |
| Skin tightness | 14.64 | 13.62 | 17 | 49449 | 2236 | 34905229 |
| Arteriovenous graft thrombosis | 14.61 | 13.62 | 3 | 49463 | 3 | 34907462 |
| Dental restoration failure | 14.50 | 13.62 | 4 | 49462 | 24 | 34907441 |
| Hepatitis | 14.30 | 13.62 | 8 | 49458 | 23896 | 34883569 |
| Pneumonia | 14.25 | 13.62 | 638 | 48828 | 361989 | 34545476 |
| Diabetic complication | 14.23 | 13.62 | 10 | 49456 | 681 | 34906784 |
| Hot flush | 14.15 | 13.62 | 4 | 49462 | 18062 | 34889403 |
| Dyskinesia | 14.15 | 13.62 | 7 | 49459 | 22406 | 34885059 |
| Diabetic gangrene | 14.14 | 13.62 | 7 | 49459 | 247 | 34907218 |
| Peripheral swelling | 14.11 | 13.62 | 58 | 49408 | 76483 | 34830982 |
| Skin hypertrophy | 14.10 | 13.62 | 18 | 49448 | 2611 | 34904854 |
| Dialysis device insertion | 14.10 | 13.62 | 4 | 49462 | 27 | 34907438 |
| Actinic keratosis | 13.95 | 13.62 | 24 | 49442 | 4543 | 34902922 |
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Death | 16900.04 | 12.40 | 8484 | 58776 | 558030 | 79119098 |
| Hospitalisation | 6091.94 | 12.40 | 2456 | 64804 | 91780 | 79585348 |
| Investigation | 2120.08 | 12.40 | 473 | 66787 | 1878 | 79675250 |
| Aplasia pure red cell | 1582.51 | 12.40 | 479 | 66781 | 7331 | 79669797 |
| Arteriovenous fistula site complication | 1205.57 | 12.40 | 255 | 67005 | 734 | 79676394 |
| Haemodialysis | 977.16 | 12.40 | 417 | 66843 | 17751 | 79659377 |
| Shunt stenosis | 540.36 | 12.40 | 142 | 67118 | 1249 | 79675879 |
| Dialysis | 479.54 | 12.40 | 257 | 67003 | 18205 | 79658923 |
| Transplant | 430.71 | 12.40 | 111 | 67149 | 897 | 79676231 |
| Shunt occlusion | 373.33 | 12.40 | 108 | 67152 | 1396 | 79675732 |
| Haemoglobin decreased | 371.60 | 12.40 | 669 | 66591 | 221450 | 79455678 |
| Haemoglobin abnormal | 362.97 | 12.40 | 157 | 67103 | 6897 | 79670231 |
| Appendicolith | 303.51 | 12.40 | 147 | 67113 | 8404 | 79668724 |
| Peritoneal dialysis | 250.96 | 12.40 | 70 | 67190 | 786 | 79676342 |
| Drug ineffective | 228.02 | 12.40 | 351 | 66909 | 1080562 | 78596566 |
| Terminal state | 210.36 | 12.40 | 96 | 67164 | 4793 | 79672335 |
| Appendicitis | 198.25 | 12.40 | 154 | 67106 | 20640 | 79656488 |
| Renal transplant | 190.10 | 12.40 | 74 | 67186 | 2473 | 79674655 |
| Anti-erythropoietin antibody positive | 175.80 | 12.40 | 51 | 67209 | 666 | 79676462 |
| Headache | 170.94 | 12.40 | 180 | 67080 | 653592 | 79023536 |
| Anaemia | 167.84 | 12.40 | 781 | 66479 | 444234 | 79232894 |
| Completed suicide | 161.38 | 12.40 | 12 | 67248 | 245755 | 79431373 |
| Arthralgia | 152.14 | 12.40 | 155 | 67105 | 571648 | 79105480 |
| Transfusion | 151.16 | 12.40 | 133 | 67127 | 21197 | 79655931 |
| Toxicity to various agents | 148.03 | 12.40 | 86 | 67174 | 421454 | 79255674 |
| Transformation to acute myeloid leukaemia | 142.96 | 12.40 | 47 | 67213 | 950 | 79676178 |
| Joint swelling | 142.85 | 12.40 | 34 | 67226 | 288612 | 79388516 |
| Sepsis | 142.52 | 12.40 | 525 | 66735 | 268903 | 79408225 |
| Renal disorder | 135.00 | 12.40 | 172 | 67088 | 41933 | 79635195 |
| Arteriovenous fistula operation | 130.61 | 12.40 | 35 | 67225 | 334 | 79676794 |
| Azotaemia | 127.04 | 12.40 | 82 | 67178 | 8194 | 79668934 |
| Rheumatoid arthritis | 126.60 | 12.40 | 14 | 67246 | 208456 | 79468672 |
| Cardiogenic shock | 121.60 | 12.40 | 163 | 67097 | 41751 | 79635377 |
| Blood phosphorus increased | 119.53 | 12.40 | 86 | 67174 | 10261 | 79666867 |
| Contraindicated product administered | 118.63 | 12.40 | 3 | 67257 | 157535 | 79519593 |
| Infusion related reaction | 118.16 | 12.40 | 25 | 67235 | 230212 | 79446916 |
| Product use issue | 118.02 | 12.40 | 18 | 67242 | 209804 | 79467324 |
| Chronic kidney disease | 113.84 | 12.40 | 202 | 67058 | 65952 | 79611176 |
| Cardiac failure | 113.37 | 12.40 | 337 | 66923 | 154505 | 79522623 |
| Ascites | 109.12 | 12.40 | 214 | 67046 | 75348 | 79601780 |
| Alopecia | 103.68 | 12.40 | 33 | 67227 | 231322 | 79445806 |
| Pain | 100.95 | 12.40 | 284 | 66976 | 703518 | 78973610 |
| Sinusitis | 100.77 | 12.40 | 21 | 67239 | 195480 | 79481648 |
| Myelodysplastic syndrome | 100.65 | 12.40 | 126 | 67134 | 30175 | 79646953 |
| Nephrogenic systemic fibrosis | 99.43 | 12.40 | 63 | 67197 | 6097 | 79671031 |
| Drug intolerance | 98.29 | 12.40 | 50 | 67210 | 264069 | 79413059 |
| Arthropathy | 95.57 | 12.40 | 17 | 67243 | 177094 | 79500034 |
| Ventricular fibrillation | 93.89 | 12.40 | 125 | 67135 | 31801 | 79645327 |
| Hepatic enzyme increased | 93.33 | 12.40 | 20 | 67240 | 182590 | 79494538 |
| Multiple organ dysfunction syndrome | 90.18 | 12.40 | 264 | 66996 | 119982 | 79557146 |
| Drug hypersensitivity | 88.88 | 12.40 | 73 | 67187 | 298843 | 79378285 |
| End stage renal disease | 88.19 | 12.40 | 77 | 67183 | 12143 | 79664985 |
| Weight increased | 87.21 | 12.40 | 64 | 67196 | 277322 | 79399806 |
| Renal impairment | 87.16 | 12.40 | 312 | 66948 | 157471 | 79519657 |
| Peritonitis | 85.90 | 12.40 | 112 | 67148 | 27924 | 79649204 |
| Abdominal discomfort | 83.94 | 12.40 | 54 | 67206 | 250673 | 79426455 |
| Hip fracture | 83.73 | 12.40 | 116 | 67144 | 30645 | 79646483 |
| Haemoglobin increased | 82.59 | 12.40 | 56 | 67204 | 6076 | 79671052 |
| Hypersensitivity | 81.80 | 12.40 | 61 | 67199 | 262178 | 79414950 |
| Rehabilitation therapy | 81.20 | 12.40 | 37 | 67223 | 1840 | 79675288 |
| Renal cyst haemorrhage | 80.97 | 12.40 | 28 | 67232 | 664 | 79676464 |
| Mineral supplementation | 79.36 | 12.40 | 29 | 67231 | 811 | 79676317 |
| Systemic lupus erythematosus | 79.24 | 12.40 | 6 | 67254 | 121143 | 79555985 |
| Angina pectoris | 77.71 | 12.40 | 149 | 67111 | 51583 | 79625545 |
| Hyperparathyroidism secondary | 77.49 | 12.40 | 40 | 67220 | 2620 | 79674508 |
| Treatment failure | 73.43 | 12.40 | 26 | 67234 | 170460 | 79506668 |
| Reticulocyte count decreased | 73.36 | 12.40 | 28 | 67232 | 886 | 79676242 |
| Arteriovenous fistula site infection | 72.71 | 12.40 | 19 | 67241 | 163 | 79676965 |
| Hyperphosphataemia | 71.38 | 12.40 | 52 | 67208 | 6324 | 79670804 |
| Intentional product use issue | 69.38 | 12.40 | 21 | 67239 | 152091 | 79525037 |
| Palliative care | 68.10 | 12.40 | 27 | 67233 | 948 | 79676180 |
| Renal failure | 67.79 | 12.40 | 342 | 66918 | 200626 | 79476502 |
| Drug interaction | 66.71 | 12.40 | 158 | 67102 | 415025 | 79262103 |
| Marasmus | 66.71 | 12.40 | 27 | 67233 | 1001 | 79676127 |
| Hypervolaemia | 66.64 | 12.40 | 125 | 67135 | 42565 | 79634563 |
| Refractory cytopenia with unilineage dysplasia | 65.95 | 12.40 | 26 | 67234 | 899 | 79676229 |
| Musculoskeletal stiffness | 65.27 | 12.40 | 33 | 67227 | 174975 | 79502153 |
| Glossodynia | 65.15 | 12.40 | 6 | 67254 | 103331 | 79573797 |
| Product use in unapproved indication | 64.02 | 12.40 | 70 | 67190 | 250289 | 79426839 |
| Peripheral swelling | 62.95 | 12.40 | 81 | 67179 | 269536 | 79407592 |
| Neoplasm malignant | 62.43 | 12.40 | 103 | 67157 | 31707 | 79645421 |
| Renal artery stenosis | 62.24 | 12.40 | 38 | 67222 | 3444 | 79673684 |
| Intermittent claudication | 59.80 | 12.40 | 37 | 67223 | 3434 | 79673694 |
| Hepatic cyst infection | 59.03 | 12.40 | 16 | 67244 | 160 | 79676968 |
| Arteriovenous fistula thrombosis | 58.76 | 12.40 | 21 | 67239 | 550 | 79676578 |
| Rash | 58.46 | 12.40 | 270 | 66990 | 578088 | 79099040 |
| Suicide attempt | 57.53 | 12.40 | 3 | 67257 | 82929 | 79594199 |
| Peripheral arterial occlusive disease | 57.52 | 12.40 | 51 | 67209 | 8207 | 79668921 |
| Dizziness | 56.06 | 12.40 | 241 | 67019 | 526200 | 79150928 |
| Pneumonia | 55.49 | 12.40 | 822 | 66438 | 659424 | 79017704 |
| Intraductal papillary mucinous neoplasm | 55.39 | 12.40 | 22 | 67238 | 776 | 79676352 |
| Therapeutic response decreased | 55.19 | 12.40 | 152 | 67108 | 66701 | 79610427 |
| Delayed graft function | 54.45 | 12.40 | 35 | 67225 | 3472 | 79673656 |
| Anxiety | 53.65 | 12.40 | 79 | 67181 | 248433 | 79428695 |
| Abdominal distension | 52.47 | 12.40 | 220 | 67040 | 119430 | 79557698 |
| Suicidal ideation | 52.22 | 12.40 | 3 | 67257 | 76337 | 79600791 |
| Pericarditis | 52.06 | 12.40 | 12 | 67248 | 104224 | 79572904 |
| Renal cyst infection | 51.55 | 12.40 | 15 | 67245 | 198 | 79676930 |
| Condition aggravated | 49.99 | 12.40 | 235 | 67025 | 500889 | 79176239 |
| Blood uric acid increased | 49.96 | 12.40 | 59 | 67201 | 13301 | 79663827 |
| Depression | 49.70 | 12.40 | 66 | 67194 | 216724 | 79460404 |
| Stress | 49.66 | 12.40 | 164 | 67096 | 79448 | 79597680 |
| Unevaluable event | 49.52 | 12.40 | 130 | 67130 | 55455 | 79621673 |
| Fatigue | 49.44 | 12.40 | 524 | 66736 | 929203 | 78747925 |
| Discomfort | 49.42 | 12.40 | 22 | 67238 | 125595 | 79551533 |
| SARS-CoV-2 antibody test positive | 48.43 | 12.40 | 17 | 67243 | 422 | 79676706 |
| Product storage error | 48.43 | 12.40 | 64 | 67196 | 16162 | 79660966 |
| Leg amputation | 48.23 | 12.40 | 33 | 67227 | 3633 | 79673495 |
| Vena cava injury | 48.09 | 12.40 | 16 | 67244 | 336 | 79676792 |
| Nasopharyngitis | 48.00 | 12.40 | 88 | 67172 | 253793 | 79423335 |
| Shunt infection | 47.23 | 12.40 | 14 | 67246 | 198 | 79676930 |
| Asthma | 46.70 | 12.40 | 28 | 67232 | 135067 | 79542061 |
| Iron deficiency | 46.54 | 12.40 | 51 | 67209 | 10603 | 79666525 |
| Reticulocyte count abnormal | 45.66 | 12.40 | 11 | 67249 | 65 | 79677063 |
| Anti-erythropoietin antibody negative | 45.04 | 12.40 | 15 | 67245 | 316 | 79676812 |
| Pleural effusion | 43.99 | 12.40 | 240 | 67020 | 145022 | 79532106 |
| Therapeutic product effect decreased | 43.91 | 12.40 | 44 | 67216 | 163819 | 79513309 |
| Living in residential institution | 43.86 | 12.40 | 18 | 67242 | 692 | 79676436 |
| Arthritis | 43.83 | 12.40 | 21 | 67239 | 114859 | 79562269 |
| Thrombocytopenia | 43.63 | 12.40 | 377 | 66883 | 264882 | 79412246 |
| Vascular anastomotic haemorrhage | 43.05 | 12.40 | 14 | 67246 | 273 | 79676855 |
| Iron overload | 42.99 | 12.40 | 24 | 67236 | 1840 | 79675288 |
| Hypoaesthesia | 41.72 | 12.40 | 54 | 67206 | 179298 | 79497830 |
| Zoonotic bacterial infection | 41.52 | 12.40 | 10 | 67250 | 59 | 79677069 |
| Product dose omission issue | 41.49 | 12.40 | 92 | 67168 | 247445 | 79429683 |
| Duodenal ulcer perforation | 41.32 | 12.40 | 4 | 67256 | 66207 | 79610921 |
| Injection site erythema | 41.10 | 12.40 | 8 | 67252 | 78189 | 79598939 |
| Abdominal wall haemorrhage | 40.86 | 12.40 | 17 | 67243 | 677 | 79676451 |
| Fracture | 40.65 | 12.40 | 69 | 67191 | 21732 | 79655396 |
| Loss of personal independence in daily activities | 40.30 | 12.40 | 18 | 67242 | 102562 | 79574566 |
| Memory impairment | 40.27 | 12.40 | 22 | 67238 | 111712 | 79565416 |
| Migraine | 40.03 | 12.40 | 12 | 67248 | 87481 | 79589647 |
| Perineal cyst | 39.86 | 12.40 | 13 | 67247 | 256 | 79676872 |
| Pain in extremity | 38.07 | 12.40 | 168 | 67092 | 364370 | 79312758 |
| Fibromyalgia | 37.36 | 12.40 | 5 | 67255 | 64335 | 79612793 |
| Plasma cell myeloma | 37.12 | 12.40 | 114 | 67146 | 53145 | 79623983 |
| Rectal prolapse | 36.97 | 12.40 | 23 | 67237 | 2155 | 79674973 |
| Hyperhidrosis | 36.92 | 12.40 | 44 | 67216 | 151448 | 79525680 |
| Therapeutic product effect incomplete | 36.86 | 12.40 | 39 | 67221 | 141606 | 79535522 |
| Visual impairment | 36.45 | 12.40 | 16 | 67244 | 92115 | 79585013 |
| Complications of transplanted kidney | 35.99 | 12.40 | 35 | 67225 | 6331 | 79670797 |
| Irritable bowel syndrome | 35.76 | 12.40 | 5 | 67255 | 62236 | 79614892 |
| Hyperparathyroidism | 35.42 | 12.40 | 26 | 67234 | 3198 | 79673930 |
| Cough | 34.80 | 12.40 | 175 | 67085 | 366614 | 79310514 |
| Alanine aminotransferase increased | 34.75 | 12.40 | 52 | 67208 | 162518 | 79514610 |
| Renal transplant failure | 34.57 | 12.40 | 21 | 67239 | 1886 | 79675242 |
| Blood potassium increased | 34.16 | 12.40 | 76 | 67184 | 29199 | 79647929 |
| Gastrointestinal disorder | 33.68 | 12.40 | 32 | 67228 | 122173 | 79554955 |
| Cardiac failure congestive | 33.33 | 12.40 | 220 | 67040 | 142182 | 79534946 |
| Folliculitis | 32.89 | 12.40 | 4 | 67256 | 55376 | 79621752 |
| Carotid arteriosclerosis | 32.81 | 12.40 | 23 | 67237 | 2633 | 79674495 |
| Mycobacterium marinum infection | 32.80 | 12.40 | 13 | 67247 | 456 | 79676672 |
| Cardiac output decreased | 32.70 | 12.40 | 20 | 67240 | 1818 | 79675310 |
| Erythropoiesis abnormal | 32.66 | 12.40 | 13 | 67247 | 461 | 79676667 |
| Skin induration | 31.62 | 12.40 | 28 | 67232 | 4497 | 79672631 |
| Wound | 31.35 | 12.40 | 31 | 67229 | 116148 | 79560980 |
| Nausea | 31.10 | 12.40 | 595 | 66665 | 956601 | 78720527 |
| Blister | 30.97 | 12.40 | 33 | 67227 | 119443 | 79557685 |
| Diabetic complication | 30.96 | 12.40 | 17 | 67243 | 1262 | 79675866 |
| Gangrene | 30.92 | 12.40 | 38 | 67222 | 8926 | 79668202 |
| Arteriovenous fistula occlusion | 30.75 | 12.40 | 13 | 67247 | 539 | 79676589 |
| Osteoarthritis | 30.31 | 12.40 | 18 | 67242 | 87291 | 79589837 |
| Vascular compression | 30.26 | 12.40 | 13 | 67247 | 561 | 79676567 |
| Sedation | 30.21 | 12.40 | 4 | 67256 | 51891 | 79625237 |
| Transferrin saturation increased | 30.19 | 12.40 | 9 | 67251 | 130 | 79676998 |
| Skin hypertrophy | 29.57 | 12.40 | 28 | 67232 | 4900 | 79672228 |
| Analgesic therapy | 28.89 | 12.40 | 15 | 67245 | 994 | 79676134 |
| Arteriovenous fistula site haemorrhage | 28.88 | 12.40 | 11 | 67249 | 346 | 79676782 |
| Stomatitis | 28.50 | 12.40 | 50 | 67210 | 146707 | 79530421 |
| Tachycardia | 28.22 | 12.40 | 68 | 67192 | 177700 | 79499428 |
| Serum ferritin increased | 28.10 | 12.40 | 38 | 67222 | 9809 | 79667319 |
| Gait disturbance | 27.97 | 12.40 | 86 | 67174 | 207420 | 79469708 |
| Myasthenia gravis | 27.97 | 12.40 | 39 | 67221 | 10360 | 79666768 |
| Hallucination | 27.95 | 12.40 | 19 | 67241 | 85726 | 79591402 |
| Procalcitonin abnormal | 27.94 | 12.40 | 11 | 67249 | 379 | 79676749 |
| Aortic dilatation | 27.92 | 12.40 | 18 | 67242 | 1794 | 79675334 |
| Cardiac valve disease | 27.75 | 12.40 | 29 | 67231 | 5712 | 79671416 |
| Psoriasis | 27.70 | 12.40 | 21 | 67239 | 89566 | 79587562 |
| Nasal congestion | 27.69 | 12.40 | 15 | 67245 | 76537 | 79600591 |
| Depressed mood | 27.60 | 12.40 | 4 | 67256 | 48476 | 79628652 |
| Blood parathyroid hormone increased | 27.49 | 12.40 | 23 | 67237 | 3422 | 79673706 |
| Oropharyngeal pain | 27.46 | 12.40 | 31 | 67229 | 109322 | 79567806 |
| Mean cell volume increased | 27.43 | 12.40 | 30 | 67230 | 6223 | 79670905 |
| Insomnia | 27.42 | 12.40 | 110 | 67150 | 245060 | 79432068 |
| Serotonin syndrome | 27.37 | 12.40 | 3 | 67257 | 45024 | 79632104 |
| General physical health deterioration | 27.20 | 12.40 | 353 | 66907 | 274885 | 79402243 |
| Drug-induced liver injury | 26.93 | 12.40 | 11 | 67249 | 66106 | 79611022 |
| Haemorrhage | 26.54 | 12.40 | 149 | 67111 | 90969 | 79586159 |
| Weight decreased | 26.49 | 12.40 | 183 | 67077 | 355015 | 79322113 |
| Agitation | 26.45 | 12.40 | 27 | 67233 | 99688 | 79577440 |
| Drug therapy | 26.44 | 12.40 | 15 | 67245 | 1186 | 79675942 |
| Constipation | 26.30 | 12.40 | 359 | 66901 | 282691 | 79394437 |
| Urticaria | 26.23 | 12.40 | 75 | 67185 | 185126 | 79492002 |
| Intervertebral disc space narrowing | 26.16 | 12.40 | 17 | 67243 | 1718 | 79675410 |
| Abdominal pain upper | 25.94 | 12.40 | 99 | 67161 | 223720 | 79453408 |
| Agranulocytosis | 25.65 | 12.40 | 90 | 67170 | 44940 | 79632188 |
| Liver injury | 25.47 | 12.40 | 8 | 67252 | 56606 | 79620522 |
| Hepatotoxicity | 25.46 | 12.40 | 6 | 67254 | 51346 | 79625782 |
| Shunt aneurysm | 24.69 | 12.40 | 6 | 67254 | 37 | 79677091 |
| Blood 25-hydroxycholecalciferol decreased | 24.50 | 12.40 | 10 | 67250 | 379 | 79676749 |
| Flushing | 24.45 | 12.40 | 23 | 67237 | 88245 | 79588883 |
| Feeling abnormal | 24.40 | 12.40 | 62 | 67198 | 159137 | 79517991 |
| Injection site swelling | 24.40 | 12.40 | 5 | 67255 | 47127 | 79630001 |
| Home care | 24.32 | 12.40 | 4 | 67256 | 0 | 79677128 |
| Shunt malfunction | 24.29 | 12.40 | 9 | 67251 | 262 | 79676866 |
| Type 2 diabetes mellitus | 24.09 | 12.40 | 9 | 67251 | 57113 | 79620015 |
| Muscle injury | 23.44 | 12.40 | 6 | 67254 | 48555 | 79628573 |
| Anti-erythropoietin antibody | 23.23 | 12.40 | 5 | 67255 | 16 | 79677112 |
| Skin fibrosis | 23.14 | 12.40 | 15 | 67245 | 1509 | 79675619 |
| Sleep disorder therapy | 23.11 | 12.40 | 13 | 67247 | 1011 | 79676117 |
| Premature delivery | 23.09 | 12.40 | 57 | 67203 | 23410 | 79653718 |
| Hepatosplenomegaly | 23.02 | 12.40 | 27 | 67233 | 6042 | 79671086 |
| Peritonitis bacterial | 22.98 | 12.40 | 34 | 67226 | 9533 | 79667595 |
| Hyperkalaemia | 22.81 | 12.40 | 170 | 67090 | 114228 | 79562900 |
| Haemodialysis complication | 22.78 | 12.40 | 9 | 67251 | 313 | 79676815 |
| Feeling hot | 22.66 | 12.40 | 11 | 67249 | 59723 | 79617405 |
| Blood erythropoietin increased | 22.57 | 12.40 | 5 | 67255 | 19 | 79677109 |
| Heart rate decreased | 22.36 | 12.40 | 16 | 67244 | 70300 | 79606828 |
| Angiodysplasia | 22.23 | 12.40 | 13 | 67247 | 1089 | 79676039 |
| Rhinorrhoea | 22.06 | 12.40 | 19 | 67241 | 76055 | 79601073 |
| Haemolysis | 21.87 | 12.40 | 39 | 67221 | 12773 | 79664355 |
| Metastatic neoplasm | 21.79 | 12.40 | 24 | 67236 | 5018 | 79672110 |
| Balance disorder | 21.73 | 12.40 | 31 | 67229 | 98826 | 79578302 |
| Skin tightness | 21.67 | 12.40 | 25 | 67235 | 5497 | 79671631 |
| Inappropriate schedule of product administration | 21.30 | 12.40 | 51 | 67209 | 133577 | 79543551 |
| Diverticulum intestinal | 21.27 | 12.40 | 31 | 67229 | 8574 | 79668554 |
| Injection site pain | 21.13 | 12.40 | 49 | 67211 | 129789 | 79547339 |
| PCO2 decreased | 21.02 | 12.40 | 19 | 67241 | 3135 | 79673993 |
| Injection site pruritus | 20.85 | 12.40 | 5 | 67255 | 42278 | 79634850 |
| Impaired healing | 20.78 | 12.40 | 26 | 67234 | 87629 | 79589499 |
| Vision blurred | 20.63 | 12.40 | 36 | 67224 | 105862 | 79571266 |
| Upper respiratory tract inflammation | 20.62 | 12.40 | 21 | 67239 | 4014 | 79673114 |
| Maternal condition affecting foetus | 20.44 | 12.40 | 7 | 67253 | 161 | 79676967 |
| Aortic arteriosclerosis | 20.43 | 12.40 | 31 | 67229 | 8887 | 79668241 |
| Muscle spasms | 20.43 | 12.40 | 77 | 67183 | 174653 | 79502475 |
| Serum ferritin abnormal | 20.41 | 12.40 | 9 | 67251 | 414 | 79676714 |
| Haematocrit decreased | 20.40 | 12.40 | 104 | 67156 | 61208 | 79615920 |
| Overdose | 20.37 | 12.40 | 83 | 67177 | 184123 | 79493005 |
| Thrombosis | 20.32 | 12.40 | 131 | 67129 | 83969 | 79593159 |
| Gastrointestinal haemorrhage | 20.25 | 12.40 | 202 | 67058 | 147517 | 79529611 |
| Hyperuricaemia | 20.24 | 12.40 | 36 | 67224 | 11763 | 79665365 |
| Swelling | 20.18 | 12.40 | 104 | 67156 | 216607 | 79460521 |
| Neutralising antibodies positive | 20.12 | 12.40 | 8 | 67252 | 283 | 79676845 |
| Drug ineffective for unapproved indication | 20.10 | 12.40 | 9 | 67251 | 51229 | 79625899 |
| Medication error | 20.08 | 12.40 | 17 | 67243 | 68625 | 79608503 |
| Irritability | 20.02 | 12.40 | 5 | 67255 | 41139 | 79635989 |
| Throat irritation | 19.88 | 12.40 | 5 | 67255 | 40941 | 79636187 |
| Tremor | 19.85 | 12.40 | 75 | 67185 | 170008 | 79507120 |
| Paraesthesia | 19.78 | 12.40 | 79 | 67181 | 176244 | 79500884 |
| Red blood cell sedimentation rate increased | 19.78 | 12.40 | 7 | 67253 | 45935 | 79631193 |
| Haematochezia | 19.75 | 12.40 | 27 | 67233 | 87618 | 79589510 |
| Angioedema | 19.70 | 12.40 | 21 | 67239 | 76014 | 79601114 |
| Hyponatraemia | 19.66 | 12.40 | 233 | 67027 | 177615 | 79499513 |
| Knee arthroplasty | 19.66 | 12.40 | 6 | 67254 | 43242 | 79633886 |
| Ischaemic stroke | 19.55 | 12.40 | 67 | 67193 | 33064 | 79644064 |
| Dysgeusia | 19.54 | 12.40 | 12 | 67248 | 57165 | 79619963 |
| Lymphocele | 19.48 | 12.40 | 14 | 67246 | 1667 | 79675461 |
| Colitis ulcerative | 19.47 | 12.40 | 3 | 67257 | 34739 | 79642389 |
| Cardiac disorder | 19.46 | 12.40 | 108 | 67152 | 65649 | 79611479 |
| Squamous cell carcinoma of skin | 19.35 | 12.40 | 39 | 67221 | 13994 | 79663134 |
| Toe amputation | 19.35 | 12.40 | 20 | 67240 | 3891 | 79673237 |
| Gastroenteritis | 19.31 | 12.40 | 68 | 67192 | 34014 | 79643114 |
| Ear infection | 19.24 | 12.40 | 3 | 67257 | 34429 | 79642699 |
| Hypocalcaemia | 18.99 | 12.40 | 88 | 67172 | 49836 | 79627292 |
| Dry eye | 18.95 | 12.40 | 4 | 67256 | 36927 | 79640201 |
| Product quality issue | 18.86 | 12.40 | 3 | 67257 | 33937 | 79643191 |
| Inadequate osteointegration | 18.78 | 12.40 | 4 | 67256 | 12 | 79677116 |
| Lactic acidosis | 18.72 | 12.40 | 19 | 67241 | 70340 | 79606788 |
| Diabetic gangrene | 18.69 | 12.40 | 7 | 67253 | 210 | 79676918 |
| Anaphylactic reaction | 18.66 | 12.40 | 26 | 67234 | 83717 | 79593411 |
| Hepatitis | 18.63 | 12.40 | 12 | 67248 | 55715 | 79621413 |
| Dyspepsia | 18.52 | 12.40 | 40 | 67220 | 108647 | 79568481 |
| Myalgia | 18.49 | 12.40 | 87 | 67173 | 185554 | 79491574 |
| Influenza like illness | 18.36 | 12.40 | 20 | 67240 | 71687 | 79605441 |
| Psychotic disorder | 18.36 | 12.40 | 6 | 67254 | 41396 | 79635732 |
| Large intestine polyp | 18.34 | 12.40 | 36 | 67224 | 12672 | 79664456 |
| Encephalomalacia | 18.32 | 12.40 | 12 | 67248 | 1229 | 79675899 |
| Exposure during pregnancy | 18.26 | 12.40 | 36 | 67224 | 101096 | 79576032 |
| Volume blood increased | 18.24 | 12.40 | 3 | 67257 | 0 | 79677128 |
| Cytomegalovirus pancreatitis | 18.24 | 12.40 | 3 | 67257 | 0 | 79677128 |
| Wheezing | 18.21 | 12.40 | 45 | 67215 | 116619 | 79560509 |
| Inflammation | 18.14 | 12.40 | 32 | 67228 | 93721 | 79583407 |
| PO2 decreased | 18.09 | 12.40 | 17 | 67243 | 2946 | 79674182 |
| Coma | 18.03 | 12.40 | 36 | 67224 | 100613 | 79576515 |
| Normochromic normocytic anaemia | 17.90 | 12.40 | 27 | 67233 | 7700 | 79669428 |
| Natural killer cell count | 17.89 | 12.40 | 4 | 67256 | 16 | 79677112 |
| Reticulocytopenia | 17.87 | 12.40 | 7 | 67253 | 238 | 79676890 |
| Parakeratosis | 17.78 | 12.40 | 8 | 67252 | 386 | 79676742 |
| Upper respiratory tract infection | 17.75 | 12.40 | 31 | 67229 | 91137 | 79585991 |
| Cerebral infarction | 17.73 | 12.40 | 81 | 67179 | 45595 | 79631533 |
| Amegakaryocytic thrombocytopenia | 17.70 | 12.40 | 4 | 67256 | 17 | 79677111 |
| Prescribed overdose | 17.68 | 12.40 | 5 | 67255 | 37878 | 79639250 |
| Dialysis device insertion | 17.47 | 12.40 | 5 | 67255 | 62 | 79677066 |
| Cognitive disorder | 17.36 | 12.40 | 20 | 67240 | 69906 | 79607222 |
| Kidney transplant rejection | 17.24 | 12.40 | 31 | 67229 | 10215 | 79666913 |
| Fungal endocarditis | 17.22 | 12.40 | 9 | 67251 | 605 | 79676523 |
| Blood product transfusion dependent | 17.10 | 12.40 | 8 | 67252 | 423 | 79676705 |
| Aspartate aminotransferase increased | 16.92 | 12.40 | 60 | 67200 | 138581 | 79538547 |
| Acute leukaemia | 16.92 | 12.40 | 13 | 67247 | 1713 | 79675415 |
| Disturbance in attention | 16.90 | 12.40 | 11 | 67249 | 50790 | 79626338 |
| Sleep disorder | 16.80 | 12.40 | 29 | 67231 | 85648 | 79591480 |
| Actinic keratosis | 16.76 | 12.40 | 23 | 67237 | 6019 | 79671109 |
| Chest discomfort | 16.68 | 12.40 | 60 | 67200 | 137984 | 79539144 |
| Back pain | 16.65 | 12.40 | 170 | 67090 | 304010 | 79373118 |
| Abnormal behaviour | 16.65 | 12.40 | 5 | 67255 | 36416 | 79640712 |
| Device related infection | 16.56 | 12.40 | 65 | 67195 | 34229 | 79642899 |
| Parvovirus B19 infection | 16.41 | 12.40 | 12 | 67248 | 1468 | 79675660 |
| Night sweats | 16.37 | 12.40 | 12 | 67248 | 52083 | 79625045 |
| Cardiac arrest | 16.26 | 12.40 | 219 | 67041 | 171877 | 79505251 |
| Myelodysplastic syndrome transformation | 16.24 | 12.40 | 9 | 67251 | 680 | 79676448 |
| Sopor | 16.09 | 12.40 | 4 | 67256 | 33006 | 79644122 |
| Uterine atony | 16.08 | 12.40 | 6 | 67254 | 178 | 79676950 |
| Nephrogenic anaemia | 15.88 | 12.40 | 18 | 67242 | 3884 | 79673244 |
| Dyskinesia | 15.86 | 12.40 | 9 | 67251 | 44764 | 79632364 |
| Liver function test increased | 15.58 | 12.40 | 7 | 67253 | 39766 | 79637362 |
| Heart rate increased | 15.58 | 12.40 | 51 | 67209 | 120673 | 79556455 |
| Hot flush | 15.55 | 12.40 | 14 | 67246 | 54863 | 79622265 |
| Sudden death | 15.51 | 12.40 | 48 | 67212 | 22463 | 79654665 |
| Adverse drug reaction | 15.42 | 12.40 | 20 | 67240 | 66372 | 79610756 |
| Peritoneal dialysis complication | 15.33 | 12.40 | 14 | 67246 | 2340 | 79674788 |
| Palpitations | 15.32 | 12.40 | 55 | 67205 | 126555 | 79550573 |
| Acute myeloid leukaemia | 15.29 | 12.40 | 59 | 67201 | 30826 | 79646302 |
| Bone marrow failure | 15.16 | 12.40 | 84 | 67176 | 51023 | 79626105 |
| Eye infection bacterial | 15.10 | 12.40 | 7 | 67253 | 362 | 79676766 |
| Oxygen saturation decreased | 14.99 | 12.40 | 57 | 67203 | 128990 | 79548138 |
| Injection site bruising | 14.88 | 12.40 | 8 | 67252 | 40994 | 79636134 |
| Neoplasm progression | 14.87 | 12.40 | 13 | 67247 | 51669 | 79625459 |
| Retinal artery occlusion | 14.79 | 12.40 | 16 | 67244 | 3278 | 79673850 |
| Delirium | 14.54 | 12.40 | 31 | 67229 | 84596 | 79592532 |
| Lung neoplasm malignant | 14.51 | 12.40 | 54 | 67206 | 27738 | 79649390 |
| Joint contracture | 14.50 | 12.40 | 14 | 67246 | 2510 | 79674618 |
| Renal lymphocele | 14.48 | 12.40 | 5 | 67255 | 118 | 79677010 |
| Activated partial thromboplastin time prolonged | 14.47 | 12.40 | 35 | 67225 | 14193 | 79662935 |
| Aortic valve stenosis | 14.46 | 12.40 | 20 | 67240 | 5274 | 79671854 |
| Pruritus | 14.43 | 12.40 | 240 | 67020 | 394408 | 79282720 |
| Coombs test positive | 14.35 | 12.40 | 6 | 67254 | 242 | 79676886 |
| Diabetes mellitus | 14.24 | 12.40 | 114 | 67146 | 78276 | 79598852 |
| Oedema peripheral | 14.21 | 12.40 | 295 | 66965 | 251993 | 79425135 |
| Left ventricular hypertrophy | 14.13 | 12.40 | 30 | 67230 | 11161 | 79665967 |
| Fall | 14.05 | 12.40 | 523 | 66737 | 487106 | 79190022 |
| Thrombosis in device | 14.03 | 12.40 | 20 | 67240 | 5422 | 79671706 |
| Electrocardiogram QT prolonged | 14.00 | 12.40 | 35 | 67225 | 90351 | 79586777 |
| Extramedullary haemopoiesis | 13.92 | 12.40 | 5 | 67255 | 133 | 79676995 |
| Productive cough | 13.84 | 12.40 | 34 | 67226 | 88297 | 79588831 |
| Aneurysm | 13.82 | 12.40 | 16 | 67244 | 3532 | 79673596 |
| Dialysis related complication | 13.81 | 12.40 | 6 | 67254 | 266 | 79676862 |
| Prescribed underdose | 13.58 | 12.40 | 4 | 67256 | 29510 | 79647618 |
| Abortion spontaneous | 13.58 | 12.40 | 4 | 67256 | 29503 | 79647625 |
| Interstitial lung disease | 13.56 | 12.40 | 49 | 67211 | 112551 | 79564577 |
| Occupational exposure to product | 13.44 | 12.40 | 8 | 67252 | 692 | 79676436 |
| Blood test abnormal | 13.37 | 12.40 | 39 | 67221 | 17671 | 79659457 |
| Dysphonia | 13.34 | 12.40 | 17 | 67243 | 56855 | 79620273 |
| Respiratory disorder | 13.25 | 12.40 | 11 | 67249 | 44845 | 79632283 |
| Urine odour abnormal | 13.24 | 12.40 | 21 | 67239 | 6252 | 79670876 |
| Febrile bone marrow aplasia | 13.21 | 12.40 | 32 | 67228 | 12988 | 79664140 |
| Cytokine release syndrome | 13.10 | 12.40 | 7 | 67253 | 35991 | 79641137 |
| Infective aneurysm | 13.09 | 12.40 | 9 | 67251 | 999 | 79676129 |
| Calciphylaxis | 13.03 | 12.40 | 16 | 67244 | 3754 | 79673374 |
| Shunt thrombosis | 13.02 | 12.40 | 5 | 67255 | 161 | 79676967 |
| Bursitis | 13.00 | 12.40 | 7 | 67253 | 35837 | 79641291 |
| Blood creatinine increased | 12.92 | 12.40 | 193 | 67067 | 154864 | 79522264 |
| Nightmare | 12.86 | 12.40 | 3 | 67257 | 25858 | 79651270 |
| Pulmonary fibrosis | 12.81 | 12.40 | 11 | 67249 | 44101 | 79633027 |
| Mycobacterial peritonitis | 12.76 | 12.40 | 4 | 67256 | 69 | 79677059 |
| Eye pain | 12.69 | 12.40 | 8 | 67252 | 37570 | 79639558 |
| Renal cyst | 12.65 | 12.40 | 34 | 67226 | 14698 | 79662430 |
| Blood glucose increased | 12.58 | 12.40 | 52 | 67208 | 114923 | 79562205 |
| Gastric cancer | 12.52 | 12.40 | 27 | 67233 | 10152 | 79666976 |
| Disease complication | 12.52 | 12.40 | 18 | 67242 | 4919 | 79672209 |
| Benign neoplasm | 12.50 | 12.40 | 9 | 67251 | 1074 | 79676054 |
| Spinal compression fracture | 12.47 | 12.40 | 37 | 67223 | 16921 | 79660207 |
| Poisoning | 12.44 | 12.40 | 3 | 67257 | 25269 | 79651859 |
| Nephrolithiasis | 12.43 | 12.40 | 16 | 67244 | 53275 | 79623853 |
None
| Source | Code | Description |
|---|---|---|
| ATC | B03XA02 | BLOOD AND BLOOD FORMING ORGANS ANTIANEMIC PREPARATIONS OTHER ANTIANEMIC PREPARATIONS Other antianemic preparations |
| FDA CS | M0007726 | Erythropoietin |
| FDA PE | N0000009319 | Increased Erythroid Cell Production |
| MeSH PA | D006397 | Hematinics |
| MeSH PA | D006401 | Hematologic Agents |
| FDA EPC | N0000175665 | Erythropoiesis-stimulating Agent |
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Anemia of renal disease | indication | 234348004 | |
| Anemia due to and following chemotherapy | indication | 767657005 | |
| Hypertensive disorder | contraindication | 38341003 | DOID:10763 |
None
None
None
None
None
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Erythropoietin receptor | Membrane receptor | AGONIST | DRUG LABEL | DRUG LABEL |
| ID | Source |
|---|---|
| 15UQ94PT4P | UNII |
| 4021274 | VANDF |
| C0937950 | UMLSCUI |
| CHEMBL1201566 | ChEMBL_ID |
| DB00012 | DRUGBANK_ID |
| D000068256 | MESH_DESCRIPTOR_UI |
| D03651 | KEGG_DRUG |
| 8073 | INN_ID |
| 283838 | RXNORM |
| 16174 | MMSL |
| 235606 | MMSL |
| 42263 | MMSL |
| d04771 | MMSL |
| 009195 | NDDF |
| 385608005 | SNOMEDCT_US |
| 385610007 | SNOMEDCT_US |
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| ARANESP | HUMAN PRESCRIPTION DRUG LABEL | 1 | 55513-002 | SOLUTION | 25 ug | INTRAVENOUS | BLA | 29 sections |
| ARANESP | HUMAN PRESCRIPTION DRUG LABEL | 1 | 55513-002 | SOLUTION | 25 ug | INTRAVENOUS | BLA | 29 sections |
| ARANESP | HUMAN PRESCRIPTION DRUG LABEL | 1 | 55513-002 | SOLUTION | 25 ug | INTRAVENOUS | BLA | 29 sections |
| ARANESP | HUMAN PRESCRIPTION DRUG LABEL | 1 | 55513-003 | SOLUTION | 40 ug | INTRAVENOUS | BLA | 29 sections |
| ARANESP | HUMAN PRESCRIPTION DRUG LABEL | 1 | 55513-003 | SOLUTION | 40 ug | INTRAVENOUS | BLA | 29 sections |
| ARANESP | HUMAN PRESCRIPTION DRUG LABEL | 1 | 55513-003 | SOLUTION | 40 ug | INTRAVENOUS | BLA | 29 sections |
| ARANESP | HUMAN PRESCRIPTION DRUG LABEL | 1 | 55513-004 | SOLUTION | 60 ug | INTRAVENOUS | BLA | 29 sections |
| ARANESP | HUMAN PRESCRIPTION DRUG LABEL | 1 | 55513-004 | SOLUTION | 60 ug | INTRAVENOUS | BLA | 29 sections |
| ARANESP | HUMAN PRESCRIPTION DRUG LABEL | 1 | 55513-004 | SOLUTION | 60 ug | INTRAVENOUS | BLA | 29 sections |
| ARANESP | HUMAN PRESCRIPTION DRUG LABEL | 1 | 55513-005 | SOLUTION | 100 ug | INTRAVENOUS | BLA | 29 sections |
| ARANESP | HUMAN PRESCRIPTION DRUG LABEL | 1 | 55513-005 | SOLUTION | 100 ug | INTRAVENOUS | BLA | 29 sections |
| ARANESP | HUMAN PRESCRIPTION DRUG LABEL | 1 | 55513-005 | SOLUTION | 100 ug | INTRAVENOUS | BLA | 29 sections |
| ARANESP | HUMAN PRESCRIPTION DRUG LABEL | 1 | 55513-006 | SOLUTION | 200 ug | INTRAVENOUS | BLA | 29 sections |
| ARANESP | HUMAN PRESCRIPTION DRUG LABEL | 1 | 55513-006 | SOLUTION | 200 ug | INTRAVENOUS | BLA | 29 sections |
| ARANESP | HUMAN PRESCRIPTION DRUG LABEL | 1 | 55513-006 | SOLUTION | 200 ug | INTRAVENOUS | BLA | 29 sections |
| ARANESP | HUMAN PRESCRIPTION DRUG LABEL | 1 | 55513-021 | INJECTION, SOLUTION | 40 ug | INTRAVENOUS | BLA | 29 sections |
| ARANESP | HUMAN PRESCRIPTION DRUG LABEL | 1 | 55513-021 | INJECTION, SOLUTION | 40 ug | INTRAVENOUS | BLA | 29 sections |
| ARANESP | HUMAN PRESCRIPTION DRUG LABEL | 1 | 55513-021 | INJECTION, SOLUTION | 40 ug | INTRAVENOUS | BLA | 29 sections |
| ARANESP | HUMAN PRESCRIPTION DRUG LABEL | 1 | 55513-023 | INJECTION, SOLUTION | 60 ug | INTRAVENOUS | BLA | 29 sections |
| ARANESP | HUMAN PRESCRIPTION DRUG LABEL | 1 | 55513-023 | INJECTION, SOLUTION | 60 ug | INTRAVENOUS | BLA | 29 sections |
| ARANESP | HUMAN PRESCRIPTION DRUG LABEL | 1 | 55513-023 | INJECTION, SOLUTION | 60 ug | INTRAVENOUS | BLA | 29 sections |
| ARANESP | HUMAN PRESCRIPTION DRUG LABEL | 1 | 55513-025 | INJECTION, SOLUTION | 100 ug | INTRAVENOUS | BLA | 29 sections |
| ARANESP | HUMAN PRESCRIPTION DRUG LABEL | 1 | 55513-025 | INJECTION, SOLUTION | 100 ug | INTRAVENOUS | BLA | 29 sections |
| ARANESP | HUMAN PRESCRIPTION DRUG LABEL | 1 | 55513-025 | INJECTION, SOLUTION | 100 ug | INTRAVENOUS | BLA | 29 sections |
| ARANESP | HUMAN PRESCRIPTION DRUG LABEL | 1 | 55513-027 | INJECTION, SOLUTION | 150 ug | INTRAVENOUS | BLA | 29 sections |
| ARANESP | HUMAN PRESCRIPTION DRUG LABEL | 1 | 55513-027 | INJECTION, SOLUTION | 150 ug | INTRAVENOUS | BLA | 29 sections |
| ARANESP | HUMAN PRESCRIPTION DRUG LABEL | 1 | 55513-027 | INJECTION, SOLUTION | 150 ug | INTRAVENOUS | BLA | 29 sections |
| ARANESP | HUMAN PRESCRIPTION DRUG LABEL | 1 | 55513-028 | INJECTION, SOLUTION | 200 ug | INTRAVENOUS | BLA | 29 sections |
| ARANESP | HUMAN PRESCRIPTION DRUG LABEL | 1 | 55513-028 | INJECTION, SOLUTION | 200 ug | INTRAVENOUS | BLA | 29 sections |
| ARANESP | HUMAN PRESCRIPTION DRUG LABEL | 1 | 55513-028 | INJECTION, SOLUTION | 200 ug | INTRAVENOUS | BLA | 29 sections |