Stem definition | Drug id | CAS RN |
---|---|---|
erythropoietin type blood factors | 5157 | 209810-58-2 |
Molecule | Description |
---|---|
Synonyms:
|
acts exactly like the natural erythropoietin made by the body to stimulate red blood cell production, but it is very slightly different in its structure
|
Dose | Unit | Route |
---|---|---|
4.50 | mcg | P |
None
Date | Agency | Company | Orphan |
---|---|---|---|
Sept. 17, 2001 | FDA | AMGEN |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Death | 10513.78 | 12.83 | 5078 | 35841 | 320301 | 50243904 |
Hospitalisation | 4464.45 | 12.83 | 1769 | 39150 | 66168 | 50498037 |
Investigation | 1139.50 | 12.83 | 262 | 40657 | 1290 | 50562915 |
Haemodialysis | 1031.64 | 12.83 | 348 | 40571 | 8014 | 50556191 |
Aplasia pure red cell | 958.75 | 12.83 | 280 | 40639 | 3935 | 50560270 |
Transplant | 505.33 | 12.83 | 115 | 40804 | 535 | 50563670 |
Arteriovenous fistula site complication | 469.63 | 12.83 | 103 | 40816 | 390 | 50563815 |
Dialysis | 403.26 | 12.83 | 182 | 40737 | 9256 | 50554949 |
Haemoglobin decreased | 295.01 | 12.83 | 434 | 40485 | 126782 | 50437423 |
Terminal state | 237.33 | 12.83 | 82 | 40837 | 2028 | 50562177 |
Drug ineffective | 229.26 | 12.83 | 197 | 40722 | 819136 | 49745069 |
Peritoneal dialysis | 212.65 | 12.83 | 51 | 40868 | 310 | 50563895 |
Anaemia | 211.84 | 12.83 | 561 | 40358 | 251895 | 50312310 |
Renal disorder | 192.18 | 12.83 | 167 | 40752 | 27338 | 50536867 |
Shunt stenosis | 190.59 | 12.83 | 48 | 40871 | 367 | 50563838 |
Renal transplant | 183.45 | 12.83 | 59 | 40860 | 1160 | 50563045 |
Shunt occlusion | 180.22 | 12.83 | 48 | 40871 | 468 | 50563737 |
Haemoglobin abnormal | 166.25 | 12.83 | 78 | 40841 | 4334 | 50559871 |
Therapeutic response decreased | 148.51 | 12.83 | 187 | 40732 | 47044 | 50517161 |
Palliative care | 142.98 | 12.83 | 37 | 40882 | 319 | 50563886 |
Rheumatoid arthritis | 131.93 | 12.83 | 8 | 40911 | 202542 | 50361663 |
Anti-erythropoietin antibody positive | 111.01 | 12.83 | 31 | 40888 | 366 | 50563839 |
Renal impairment | 105.54 | 12.83 | 206 | 40713 | 75455 | 50488750 |
Drug hypersensitivity | 105.04 | 12.83 | 36 | 40883 | 250974 | 50313231 |
Drug intolerance | 103.50 | 12.83 | 25 | 40894 | 219079 | 50345126 |
Headache | 102.82 | 12.83 | 157 | 40762 | 506378 | 50057827 |
Transfusion | 97.55 | 12.83 | 82 | 40837 | 12823 | 50551382 |
Joint swelling | 96.22 | 12.83 | 39 | 40880 | 245247 | 50318958 |
Renal failure | 95.30 | 12.83 | 243 | 40676 | 106390 | 50457815 |
Arteriovenous fistula operation | 93.05 | 12.83 | 24 | 40895 | 204 | 50564001 |
Peritonitis | 92.30 | 12.83 | 86 | 40833 | 15400 | 50548805 |
Condition aggravated | 90.62 | 12.83 | 65 | 40854 | 296993 | 50267212 |
Infusion related reaction | 89.10 | 12.83 | 15 | 40904 | 169542 | 50394663 |
Arthralgia | 87.02 | 12.83 | 138 | 40781 | 438564 | 50125641 |
Product use issue | 83.65 | 12.83 | 11 | 40908 | 149464 | 50414741 |
Haemoglobin increased | 81.55 | 12.83 | 43 | 40876 | 3072 | 50561133 |
Myelodysplastic syndrome | 80.63 | 12.83 | 79 | 40840 | 15053 | 50549152 |
Arthropathy | 78.60 | 12.83 | 16 | 40903 | 157890 | 50406315 |
Completed suicide | 75.51 | 12.83 | 9 | 40910 | 131880 | 50432325 |
Alopecia | 75.51 | 12.83 | 53 | 40866 | 244994 | 50319211 |
Pain | 75.36 | 12.83 | 230 | 40689 | 578673 | 49985532 |
Toxicity to various agents | 72.29 | 12.83 | 41 | 40878 | 212458 | 50351747 |
Sinusitis | 72.11 | 12.83 | 24 | 40895 | 170534 | 50393671 |
Abdominal discomfort | 70.19 | 12.83 | 51 | 40868 | 231590 | 50332615 |
Systemic lupus erythematosus | 68.44 | 12.83 | 15 | 40904 | 140607 | 50423598 |
Cardiac failure | 66.57 | 12.83 | 172 | 40747 | 75868 | 50488337 |
Mineral supplementation | 66.54 | 12.83 | 24 | 40895 | 675 | 50563530 |
Hepatic enzyme increased | 66.16 | 12.83 | 15 | 40904 | 137365 | 50426840 |
Glossodynia | 63.47 | 12.83 | 9 | 40910 | 115560 | 50448645 |
Unevaluable event | 62.47 | 12.83 | 124 | 40795 | 45942 | 50518263 |
Swelling | 62.45 | 12.83 | 43 | 40876 | 200829 | 50363376 |
Weight increased | 59.15 | 12.83 | 46 | 40873 | 201845 | 50362360 |
Rehabilitation therapy | 58.22 | 12.83 | 26 | 40893 | 1287 | 50562918 |
Hip fracture | 57.82 | 12.83 | 87 | 40832 | 25844 | 50538361 |
Nephrogenic systemic fibrosis | 56.19 | 12.83 | 38 | 40881 | 4284 | 50559921 |
Azotaemia | 53.93 | 12.83 | 36 | 40883 | 3972 | 50560233 |
Treatment failure | 53.73 | 12.83 | 22 | 40897 | 137615 | 50426590 |
Refractory cytopenia with unilineage dysplasia | 49.71 | 12.83 | 18 | 40901 | 512 | 50563693 |
Transformation to acute myeloid leukaemia | 49.11 | 12.83 | 14 | 40905 | 179 | 50564026 |
Thrombocytopenia | 48.35 | 12.83 | 218 | 40701 | 127455 | 50436750 |
Cardiac output decreased | 47.00 | 12.83 | 20 | 40899 | 880 | 50563325 |
Musculoskeletal stiffness | 46.29 | 12.83 | 23 | 40896 | 128458 | 50435747 |
Wound | 46.27 | 12.83 | 14 | 40905 | 105780 | 50458425 |
Nasopharyngitis | 45.91 | 12.83 | 53 | 40866 | 192874 | 50371331 |
Therapeutic product effect decreased | 45.17 | 12.83 | 27 | 40892 | 136023 | 50428182 |
Psoriasis | 44.06 | 12.83 | 3 | 40916 | 68997 | 50495208 |
Injection site erythema | 43.16 | 12.83 | 5 | 40914 | 74931 | 50489274 |
Hypervolaemia | 42.50 | 12.83 | 75 | 40844 | 25424 | 50538781 |
Reticulocyte count decreased | 42.41 | 12.83 | 15 | 40904 | 398 | 50563807 |
Hypersensitivity | 42.24 | 12.83 | 68 | 40851 | 215093 | 50349112 |
End stage renal disease | 40.38 | 12.83 | 35 | 40884 | 5702 | 50558503 |
Pleural effusion | 40.24 | 12.83 | 151 | 40768 | 81303 | 50482902 |
Chronic kidney disease | 40.11 | 12.83 | 95 | 40824 | 39676 | 50524529 |
Haemodialysis complication | 39.67 | 12.83 | 12 | 40907 | 191 | 50564014 |
Occupational exposure to product | 39.21 | 12.83 | 22 | 40897 | 1778 | 50562427 |
Arteriovenous fistula site infection | 39.00 | 12.83 | 9 | 40910 | 45 | 50564160 |
Peripheral swelling | 38.64 | 12.83 | 67 | 40852 | 205869 | 50358336 |
Anti-erythropoietin antibody negative | 38.26 | 12.83 | 10 | 40909 | 90 | 50564115 |
Hepatic cyst infection | 37.59 | 12.83 | 10 | 40909 | 97 | 50564108 |
Living in residential institution | 36.96 | 12.83 | 14 | 40905 | 453 | 50563752 |
Therapeutic product effect incomplete | 36.73 | 12.83 | 14 | 40905 | 91501 | 50472704 |
Discomfort | 36.69 | 12.83 | 21 | 40898 | 108359 | 50455846 |
Drug specific antibody absent | 36.68 | 12.83 | 9 | 40910 | 61 | 50564144 |
Drug interaction | 36.50 | 12.83 | 66 | 40853 | 199555 | 50364650 |
Nausea | 36.09 | 12.83 | 381 | 40538 | 705017 | 49859188 |
Disease progression | 35.76 | 12.83 | 163 | 40756 | 95703 | 50468502 |
Rash | 35.55 | 12.83 | 208 | 40711 | 437263 | 50126942 |
Blood parathyroid hormone increased | 34.52 | 12.83 | 24 | 40895 | 2830 | 50561375 |
Cardiac disorder | 34.33 | 12.83 | 94 | 40825 | 42885 | 50521320 |
Intentional product use issue | 33.95 | 12.83 | 10 | 40909 | 76908 | 50487297 |
Suicidal ideation | 33.70 | 12.83 | 3 | 40916 | 55382 | 50508823 |
Somnolence | 33.29 | 12.83 | 46 | 40873 | 154939 | 50409266 |
Fall | 33.21 | 12.83 | 415 | 40504 | 334517 | 50229688 |
Leukopenia | 33.19 | 12.83 | 125 | 40794 | 67403 | 50496802 |
Reticulocyte count abnormal | 32.89 | 12.83 | 8 | 40911 | 52 | 50564153 |
Renal cyst infection | 31.94 | 12.83 | 9 | 40910 | 110 | 50564095 |
Plasma cell myeloma | 31.78 | 12.83 | 75 | 40844 | 31247 | 50532958 |
Pancytopenia | 30.68 | 12.83 | 142 | 40777 | 83888 | 50480317 |
Iron deficiency | 30.10 | 12.83 | 30 | 40889 | 5832 | 50558373 |
Depression | 29.96 | 12.83 | 55 | 40864 | 165368 | 50398837 |
Urinary tract infection | 29.68 | 12.83 | 294 | 40625 | 223726 | 50340479 |
Shunt infection | 29.12 | 12.83 | 7 | 40912 | 43 | 50564162 |
Blood cholesterol increased | 28.72 | 12.83 | 5 | 40914 | 55210 | 50508995 |
Pericarditis | 28.46 | 12.83 | 14 | 40905 | 78675 | 50485530 |
Anti-erythropoietin antibody | 28.26 | 12.83 | 5 | 40914 | 3 | 50564202 |
Sepsis | 28.14 | 12.83 | 194 | 40725 | 132731 | 50431474 |
Dizziness | 27.93 | 12.83 | 165 | 40754 | 346204 | 50218001 |
Pneumonia | 27.90 | 12.83 | 445 | 40474 | 377956 | 50186249 |
Neoplasm malignant | 27.64 | 12.83 | 60 | 40859 | 23655 | 50540550 |
Serum ferritin increased | 27.41 | 12.83 | 27 | 40892 | 5175 | 50559030 |
Marasmus | 27.10 | 12.83 | 11 | 40908 | 429 | 50563776 |
Diabetic complication | 26.69 | 12.83 | 13 | 40906 | 785 | 50563420 |
Duodenal ulcer perforation | 26.37 | 12.83 | 3 | 40916 | 45608 | 50518597 |
Product use in unapproved indication | 26.28 | 12.83 | 33 | 40886 | 115786 | 50448419 |
Fungal endocarditis | 26.26 | 12.83 | 9 | 40910 | 217 | 50563988 |
Bone marrow failure | 25.73 | 12.83 | 64 | 40855 | 27560 | 50536645 |
Arthritis | 25.06 | 12.83 | 20 | 40899 | 86701 | 50477504 |
Home care | 24.48 | 12.83 | 4 | 40915 | 0 | 50564205 |
Blood creatinine increased | 24.42 | 12.83 | 124 | 40795 | 76036 | 50488169 |
Premature delivery | 24.37 | 12.83 | 57 | 40862 | 23606 | 50540599 |
Sleep disorder | 24.29 | 12.83 | 8 | 40911 | 57275 | 50506930 |
Irritable bowel syndrome | 23.99 | 12.83 | 6 | 40913 | 51435 | 50512770 |
Product dose omission issue | 23.81 | 12.83 | 73 | 40846 | 183765 | 50380440 |
Migraine | 23.52 | 12.83 | 16 | 40903 | 75264 | 50488941 |
Arteriovenous fistula thrombosis | 23.37 | 12.83 | 8 | 40911 | 192 | 50564013 |
Hypertension | 23.21 | 12.83 | 267 | 40652 | 210936 | 50353269 |
Skin induration | 23.04 | 12.83 | 19 | 40900 | 2892 | 50561313 |
Eye infection bacterial | 22.99 | 12.83 | 7 | 40912 | 114 | 50564091 |
Off label use | 22.64 | 12.83 | 522 | 40397 | 473904 | 50090301 |
Injection site pruritus | 22.52 | 12.83 | 3 | 40916 | 40408 | 50523797 |
Memory impairment | 22.07 | 12.83 | 19 | 40900 | 79341 | 50484864 |
Transplant failure | 22.05 | 12.83 | 14 | 40905 | 1419 | 50562786 |
Pain in extremity | 21.97 | 12.83 | 130 | 40789 | 272735 | 50291470 |
Insomnia | 21.55 | 12.83 | 71 | 40848 | 174794 | 50389411 |
Infective aneurysm | 21.28 | 12.83 | 9 | 40910 | 390 | 50563815 |
Hyperphosphataemia | 20.93 | 12.83 | 15 | 40904 | 1856 | 50562349 |
Myelodysplastic syndrome transformation | 20.77 | 12.83 | 9 | 40910 | 414 | 50563791 |
Asthma | 20.74 | 12.83 | 25 | 40894 | 89312 | 50474893 |
Cellulitis | 20.45 | 12.83 | 112 | 40807 | 70686 | 50493519 |
Product storage error | 20.43 | 12.83 | 36 | 40883 | 12188 | 50552017 |
Nasal congestion | 20.21 | 12.83 | 8 | 40911 | 51112 | 50513093 |
Blood erythropoietin increased | 20.10 | 12.83 | 4 | 40915 | 8 | 50564197 |
Kidney transplant rejection | 19.73 | 12.83 | 20 | 40899 | 3967 | 50560238 |
Blood potassium increased | 19.69 | 12.83 | 42 | 40877 | 16356 | 50547849 |
Angina pectoris | 19.65 | 12.83 | 56 | 40863 | 26132 | 50538073 |
Exposure during pregnancy | 19.53 | 12.83 | 43 | 40876 | 120972 | 50443233 |
Visual impairment | 19.41 | 12.83 | 16 | 40903 | 68259 | 50495946 |
Loss of personal independence in daily activities | 19.20 | 12.83 | 17 | 40902 | 70033 | 50494172 |
Haemolysis | 19.18 | 12.83 | 24 | 40895 | 5992 | 50558213 |
Extramedullary haemopoiesis | 18.84 | 12.83 | 5 | 40914 | 48 | 50564157 |
Iron overload | 18.83 | 12.83 | 10 | 40909 | 725 | 50563480 |
Gastrointestinal disorder | 18.37 | 12.83 | 30 | 40889 | 94426 | 50469779 |
Natural killer cell count | 18.06 | 12.83 | 4 | 40915 | 16 | 50564189 |
Amegakaryocytic thrombocytopenia | 18.06 | 12.83 | 4 | 40915 | 16 | 50564189 |
Urine odour abnormal | 18.04 | 12.83 | 22 | 40897 | 5351 | 50558854 |
Hypocalcaemia | 17.89 | 12.83 | 55 | 40864 | 26761 | 50537444 |
Hyperparathyroidism secondary | 17.86 | 12.83 | 12 | 40907 | 1338 | 50562867 |
Leg amputation | 17.76 | 12.83 | 14 | 40905 | 1999 | 50562206 |
Epistaxis | 17.69 | 12.83 | 100 | 40819 | 63854 | 50500351 |
Renal transplant failure | 17.59 | 12.83 | 9 | 40910 | 604 | 50563601 |
Parakeratosis | 17.57 | 12.83 | 7 | 40912 | 260 | 50563945 |
Folliculitis | 17.49 | 12.83 | 5 | 40914 | 39220 | 50524985 |
Oedema peripheral | 17.48 | 12.83 | 200 | 40719 | 157761 | 50406444 |
Anxiety | 17.45 | 12.83 | 79 | 40840 | 177527 | 50386678 |
Knee arthroplasty | 17.07 | 12.83 | 4 | 40915 | 35842 | 50528363 |
Gait disturbance | 17.07 | 12.83 | 63 | 40856 | 149942 | 50414263 |
Blood product transfusion dependent | 17.01 | 12.83 | 6 | 40913 | 158 | 50564047 |
Dialysis related complication | 16.99 | 12.83 | 5 | 40914 | 72 | 50564133 |
Macrophages increased | 16.87 | 12.83 | 4 | 40915 | 23 | 50564182 |
Blister | 16.73 | 12.83 | 27 | 40892 | 85391 | 50478814 |
Dry eye | 16.49 | 12.83 | 3 | 40916 | 32092 | 50532113 |
Maternal condition affecting foetus | 16.40 | 12.83 | 6 | 40913 | 176 | 50564029 |
Arteriovenous fistula site haemorrhage | 16.27 | 12.83 | 6 | 40913 | 180 | 50564025 |
Skin hypertrophy | 16.19 | 12.83 | 16 | 40903 | 3079 | 50561126 |
Uterine atony | 16.08 | 12.83 | 6 | 40913 | 186 | 50564019 |
Blood test abnormal | 15.98 | 12.83 | 31 | 40888 | 11288 | 50552917 |
Serum ferritin abnormal | 15.93 | 12.83 | 6 | 40913 | 191 | 50564014 |
Agitation | 15.82 | 12.83 | 12 | 40907 | 53372 | 50510833 |
Abortion spontaneous | 15.77 | 12.83 | 7 | 40912 | 41765 | 50522440 |
Neutropenia | 15.77 | 12.83 | 186 | 40733 | 147779 | 50416426 |
Impaired healing | 15.70 | 12.83 | 20 | 40899 | 69766 | 50494439 |
Intermittent claudication | 15.66 | 12.83 | 12 | 40907 | 1643 | 50562562 |
Cough | 15.42 | 12.83 | 123 | 40796 | 241141 | 50323064 |
Nephrogenic anaemia | 15.35 | 12.83 | 12 | 40907 | 1693 | 50562512 |
Arteriovenous fistula occlusion | 15.21 | 12.83 | 7 | 40912 | 372 | 50563833 |
Marrow hyperplasia | 15.20 | 12.83 | 8 | 40911 | 569 | 50563636 |
Acute myeloid leukaemia | 15.18 | 12.83 | 36 | 40883 | 15038 | 50549167 |
Shunt thrombosis | 15.11 | 12.83 | 4 | 40915 | 38 | 50564167 |
Osteoarthritis | 15.09 | 12.83 | 20 | 40899 | 68586 | 50495619 |
Proteinuria | 14.98 | 12.83 | 38 | 40881 | 16559 | 50547646 |
Ischaemic stroke | 14.90 | 12.83 | 37 | 40882 | 15911 | 50548294 |
Skin fibrosis | 14.75 | 12.83 | 9 | 40910 | 850 | 50563355 |
Flushing | 14.27 | 12.83 | 20 | 40899 | 66995 | 50497210 |
Overdose | 14.07 | 12.83 | 38 | 40881 | 99689 | 50464516 |
Maternal exposure during pregnancy | 14.00 | 12.83 | 74 | 40845 | 159704 | 50404501 |
Vascular shunt | 13.97 | 12.83 | 3 | 40916 | 10 | 50564195 |
Cerebrovascular accident | 13.87 | 12.83 | 127 | 40792 | 94553 | 50469652 |
Anaphylactic reaction | 13.78 | 12.83 | 14 | 40905 | 54041 | 50510164 |
Medication error | 13.71 | 12.83 | 6 | 40913 | 36098 | 50528107 |
No adverse event | 13.70 | 12.83 | 5 | 40914 | 33573 | 50530632 |
Product quality issue | 13.63 | 12.83 | 4 | 40915 | 30854 | 50533351 |
Myalgia | 13.63 | 12.83 | 53 | 40866 | 124266 | 50439939 |
Wrong technique in product usage process | 13.46 | 12.83 | 15 | 40904 | 55495 | 50508710 |
Mycobacterial peritonitis | 13.38 | 12.83 | 4 | 40915 | 61 | 50564144 |
Device related infection | 13.34 | 12.83 | 42 | 40877 | 20693 | 50543512 |
Hyperkalaemia | 13.17 | 12.83 | 75 | 40844 | 48014 | 50516191 |
Urticaria | 13.10 | 12.83 | 57 | 40862 | 129504 | 50434701 |
Renal lymphocele | 13.09 | 12.83 | 4 | 40915 | 66 | 50564139 |
Fatigue | 13.08 | 12.83 | 455 | 40464 | 707146 | 49857059 |
Hepatotoxicity | 13.04 | 12.83 | 3 | 40916 | 27223 | 50536982 |
Upper limb fracture | 12.95 | 12.83 | 35 | 40884 | 15838 | 50548367 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Death | 12162.71 | 13.47 | 6959 | 37619 | 335125 | 29194824 |
Hospitalisation | 4887.36 | 13.47 | 2015 | 42563 | 43973 | 29485976 |
Aplasia pure red cell | 1176.78 | 13.47 | 404 | 44174 | 5087 | 29524862 |
Haemodialysis | 1033.17 | 13.47 | 431 | 44147 | 9523 | 29520426 |
Investigation | 879.60 | 13.47 | 214 | 44364 | 650 | 29529299 |
Arteriovenous fistula site complication | 708.77 | 13.47 | 157 | 44421 | 265 | 29529684 |
Transplant | 426.19 | 13.47 | 115 | 44463 | 582 | 29529367 |
Dialysis | 399.85 | 13.47 | 227 | 44351 | 9981 | 29519968 |
Peritoneal dialysis | 262.39 | 13.47 | 74 | 44504 | 453 | 29529496 |
Haemoglobin abnormal | 243.35 | 13.47 | 111 | 44467 | 3050 | 29526899 |
Haemoglobin decreased | 233.05 | 13.47 | 508 | 44070 | 107867 | 29422082 |
Anti-erythropoietin antibody positive | 190.81 | 13.47 | 65 | 44513 | 795 | 29529154 |
Shunt stenosis | 189.52 | 13.47 | 59 | 44519 | 530 | 29529419 |
Renal disorder | 174.39 | 13.47 | 192 | 44386 | 22403 | 29507546 |
Therapeutic response decreased | 172.01 | 13.47 | 199 | 44379 | 24512 | 29505437 |
Terminal state | 159.54 | 13.47 | 86 | 44492 | 3408 | 29526541 |
Appendicolith | 140.56 | 13.47 | 79 | 44499 | 3401 | 29526548 |
Transfusion | 138.49 | 13.47 | 103 | 44475 | 7195 | 29522754 |
Shunt occlusion | 126.48 | 13.47 | 46 | 44532 | 690 | 29529259 |
Toxicity to various agents | 126.22 | 13.47 | 52 | 44526 | 173609 | 29356340 |
Palliative care | 110.70 | 13.47 | 37 | 44541 | 425 | 29529524 |
Renal transplant | 109.57 | 13.47 | 52 | 44526 | 1566 | 29528383 |
Arteriovenous fistula operation | 102.37 | 13.47 | 27 | 44551 | 123 | 29529826 |
Reticulocyte count decreased | 92.81 | 13.47 | 34 | 44544 | 521 | 29529428 |
Drug ineffective | 87.45 | 13.47 | 270 | 44308 | 362900 | 29167049 |
Drug interaction | 86.76 | 13.47 | 102 | 44476 | 197283 | 29332666 |
Haemoglobin increased | 81.39 | 13.47 | 52 | 44526 | 2834 | 29527115 |
Appendicitis | 80.86 | 13.47 | 82 | 44496 | 8697 | 29521252 |
Transformation to acute myeloid leukaemia | 78.47 | 13.47 | 32 | 44546 | 663 | 29529286 |
Anaemia | 74.59 | 13.47 | 538 | 44040 | 200413 | 29329536 |
Myelodysplastic syndrome | 73.56 | 13.47 | 111 | 44467 | 17683 | 29512266 |
Product use in unapproved indication | 73.51 | 13.47 | 20 | 44558 | 86855 | 29443094 |
Peritonitis | 70.78 | 13.47 | 99 | 44479 | 14725 | 29515224 |
Lower respiratory tract infection | 69.44 | 13.47 | 135 | 44443 | 26367 | 29503582 |
Neoplasm malignant | 66.33 | 13.47 | 103 | 44475 | 16822 | 29513127 |
Hip fracture | 63.93 | 13.47 | 79 | 44499 | 10413 | 29519536 |
Product use issue | 61.75 | 13.47 | 4 | 44574 | 51440 | 29478509 |
Mineral supplementation | 60.82 | 13.47 | 16 | 44562 | 72 | 29529877 |
Living in residential institution | 60.20 | 13.47 | 21 | 44557 | 277 | 29529672 |
Headache | 59.62 | 13.47 | 107 | 44471 | 173900 | 29356049 |
Nephrogenic systemic fibrosis | 56.16 | 13.47 | 47 | 44531 | 3895 | 29526054 |
Azotaemia | 54.17 | 13.47 | 49 | 44529 | 4508 | 29525441 |
Chronic kidney disease | 51.81 | 13.47 | 146 | 44432 | 36270 | 29493679 |
Arteriovenous fistula site infection | 47.81 | 13.47 | 13 | 44565 | 68 | 29529881 |
Arteriovenous fistula thrombosis | 46.83 | 13.47 | 18 | 44560 | 317 | 29529632 |
Product storage error | 46.49 | 13.47 | 53 | 44525 | 6417 | 29523532 |
Cardiogenic shock | 44.59 | 13.47 | 93 | 44485 | 19097 | 29510852 |
Alanine aminotransferase increased | 44.24 | 13.47 | 26 | 44552 | 70918 | 29459031 |
Unevaluable event | 43.76 | 13.47 | 121 | 44457 | 29730 | 29500219 |
Product dose omission issue | 42.05 | 13.47 | 50 | 44528 | 96333 | 29433616 |
Aggression | 41.95 | 13.47 | 3 | 44575 | 35538 | 29494411 |
Somnolence | 41.79 | 13.47 | 48 | 44530 | 93907 | 29436042 |
Rehabilitation therapy | 41.60 | 13.47 | 20 | 44558 | 620 | 29529329 |
Intentional product use issue | 41.60 | 13.47 | 7 | 44571 | 42491 | 29487458 |
Angina pectoris | 40.93 | 13.47 | 113 | 44465 | 27737 | 29502212 |
Suicidal ideation | 40.78 | 13.47 | 3 | 44575 | 34713 | 29495236 |
Arthralgia | 39.25 | 13.47 | 96 | 44482 | 139521 | 29390428 |
Overdose | 38.59 | 13.47 | 38 | 44540 | 79781 | 29450168 |
Hyperparathyroidism secondary | 38.52 | 13.47 | 24 | 44554 | 1251 | 29528698 |
Hyperhidrosis | 38.37 | 13.47 | 25 | 44553 | 64515 | 29465434 |
Refractory cytopenia with unilineage dysplasia | 38.16 | 13.47 | 17 | 44561 | 441 | 29529508 |
Condition aggravated | 37.75 | 13.47 | 105 | 44473 | 146190 | 29383759 |
Depression | 37.32 | 13.47 | 44 | 44534 | 85103 | 29444846 |
Zoonotic bacterial infection | 37.32 | 13.47 | 10 | 44568 | 49 | 29529900 |
Urinary tract infection | 36.77 | 13.47 | 210 | 44368 | 72144 | 29457805 |
Hypervolaemia | 36.15 | 13.47 | 81 | 44497 | 17464 | 29512485 |
Weight increased | 35.37 | 13.47 | 38 | 44540 | 76629 | 29453320 |
Intermittent claudication | 34.68 | 13.47 | 27 | 44551 | 2018 | 29527931 |
Sepsis | 34.26 | 13.47 | 347 | 44231 | 142335 | 29387614 |
Joint swelling | 34.17 | 13.47 | 16 | 44562 | 49614 | 29480335 |
Ascites | 34.08 | 13.47 | 127 | 44451 | 36492 | 29493457 |
Infusion related reaction | 33.70 | 13.47 | 12 | 44566 | 43874 | 29486075 |
Normochromic normocytic anaemia | 33.37 | 13.47 | 34 | 44544 | 3624 | 29526325 |
Hallucination | 33.04 | 13.47 | 13 | 44565 | 44699 | 29485250 |
Home care | 32.99 | 13.47 | 6 | 44572 | 0 | 29529949 |
Leg amputation | 32.32 | 13.47 | 26 | 44552 | 2038 | 29527911 |
Treatment failure | 32.18 | 13.47 | 8 | 44570 | 36931 | 29493018 |
Aspartate aminotransferase increased | 31.78 | 13.47 | 26 | 44552 | 59699 | 29470250 |
Erythropoiesis abnormal | 31.56 | 13.47 | 12 | 44566 | 205 | 29529744 |
Drug hypersensitivity | 31.44 | 13.47 | 34 | 44544 | 68372 | 29461577 |
Dizziness | 30.93 | 13.47 | 164 | 44414 | 189520 | 29340429 |
Renal cyst haemorrhage | 30.47 | 13.47 | 14 | 44564 | 391 | 29529558 |
Agitation | 30.32 | 13.47 | 20 | 44558 | 51284 | 29478665 |
Intraductal papillary mucinous neoplasm | 29.55 | 13.47 | 13 | 44565 | 327 | 29529622 |
Stress | 29.43 | 13.47 | 85 | 44493 | 21405 | 29508544 |
Hepatic cyst infection | 29.07 | 13.47 | 7 | 44571 | 20 | 29529929 |
Rectal prolapse | 28.97 | 13.47 | 12 | 44566 | 259 | 29529690 |
Sinusitis | 28.86 | 13.47 | 8 | 44570 | 34342 | 29495607 |
Mycobacterium marinum infection | 28.15 | 13.47 | 12 | 44566 | 279 | 29529670 |
Reticulocytopenia | 27.53 | 13.47 | 9 | 44569 | 96 | 29529853 |
Angiodysplasia | 27.27 | 13.47 | 14 | 44564 | 501 | 29529448 |
Tremor | 27.18 | 13.47 | 43 | 44535 | 73495 | 29456454 |
Rhabdomyolysis | 27.09 | 13.47 | 31 | 44547 | 60777 | 29469172 |
Tachycardia | 27.09 | 13.47 | 42 | 44536 | 72368 | 29457581 |
Hepatic enzyme increased | 26.36 | 13.47 | 9 | 44569 | 33790 | 29496159 |
Rheumatoid arthritis | 26.07 | 13.47 | 8 | 44570 | 32144 | 29497805 |
Catheter removal | 25.72 | 13.47 | 10 | 44568 | 182 | 29529767 |
Lactic acidosis | 25.49 | 13.47 | 7 | 44571 | 30240 | 29499709 |
Renal artery stenosis | 25.12 | 13.47 | 22 | 44556 | 1939 | 29528010 |
Marasmus | 24.90 | 13.47 | 13 | 44565 | 482 | 29529467 |
Vena cava injury | 24.49 | 13.47 | 10 | 44568 | 208 | 29529741 |
Gangrene | 24.48 | 13.47 | 31 | 44547 | 4187 | 29525762 |
Interstitial lung disease | 24.05 | 13.47 | 31 | 44547 | 57687 | 29472262 |
SARS-CoV-2 antibody test positive | 23.84 | 13.47 | 10 | 44568 | 223 | 29529726 |
Blood iron abnormal | 23.65 | 13.47 | 7 | 44571 | 52 | 29529897 |
Parvovirus B19 test positive | 23.54 | 13.47 | 8 | 44570 | 97 | 29529852 |
Delayed graft function | 23.45 | 13.47 | 21 | 44557 | 1906 | 29528043 |
Chest discomfort | 23.26 | 13.47 | 21 | 44557 | 45962 | 29483987 |
Irritability | 23.17 | 13.47 | 3 | 44575 | 22149 | 29507800 |
Anxiety | 22.95 | 13.47 | 60 | 44518 | 85305 | 29444644 |
Respiratory failure | 22.66 | 13.47 | 73 | 44505 | 97058 | 29432891 |
Blood creatine phosphokinase increased | 22.49 | 13.47 | 17 | 44561 | 40627 | 29489322 |
Drug-induced liver injury | 22.49 | 13.47 | 3 | 44575 | 21652 | 29508297 |
Transferrin saturation increased | 22.47 | 13.47 | 7 | 44571 | 63 | 29529886 |
Rash | 22.36 | 13.47 | 181 | 44397 | 189638 | 29340311 |
Myalgia | 22.30 | 13.47 | 49 | 44529 | 73970 | 29455979 |
Peritoneal catheter insertion | 22.00 | 13.47 | 4 | 44574 | 0 | 29529949 |
Anti-erythropoietin antibody | 22.00 | 13.47 | 4 | 44574 | 0 | 29529949 |
Pleural effusion | 21.83 | 13.47 | 184 | 44394 | 71724 | 29458225 |
Peripheral arterial occlusive disease | 21.45 | 13.47 | 32 | 44546 | 5044 | 29524905 |
Cardio-respiratory arrest | 21.26 | 13.47 | 27 | 44551 | 50574 | 29479375 |
End stage renal disease | 21.24 | 13.47 | 40 | 44538 | 7624 | 29522325 |
Pyrexia | 21.11 | 13.47 | 306 | 44272 | 287316 | 29242633 |
Multiple organ dysfunction syndrome | 21.05 | 13.47 | 165 | 44413 | 62951 | 29466998 |
Procalcitonin abnormal | 21.04 | 13.47 | 10 | 44568 | 302 | 29529647 |
Angioedema | 20.89 | 13.47 | 11 | 44567 | 31904 | 29498045 |
Catheter placement | 20.88 | 13.47 | 13 | 44565 | 677 | 29529272 |
Cognitive disorder | 20.64 | 13.47 | 5 | 44573 | 23494 | 29506455 |
Weight decreased | 20.59 | 13.47 | 138 | 44440 | 150767 | 29379182 |
Inappropriate schedule of product administration | 20.55 | 13.47 | 22 | 44556 | 44450 | 29485499 |
Non-neutralising antibodies positive | 20.52 | 13.47 | 7 | 44571 | 86 | 29529863 |
Asthma | 20.26 | 13.47 | 13 | 44565 | 33836 | 29496113 |
Acute respiratory distress syndrome | 19.91 | 13.47 | 5 | 44573 | 22930 | 29507019 |
Muscle spasms | 19.67 | 13.47 | 43 | 44535 | 65039 | 29464910 |
Renal cyst infection | 19.67 | 13.47 | 6 | 44572 | 50 | 29529899 |
Cardiac failure | 19.56 | 13.47 | 194 | 44384 | 79093 | 29450856 |
Nausea | 19.43 | 13.47 | 313 | 44265 | 288942 | 29241007 |
Hyperparathyroidism | 19.26 | 13.47 | 15 | 44563 | 1122 | 29528827 |
Metastatic neoplasm | 19.25 | 13.47 | 22 | 44556 | 2670 | 29527279 |
Musculoskeletal stiffness | 19.07 | 13.47 | 17 | 44561 | 37441 | 29492508 |
Iron overload | 19.05 | 13.47 | 15 | 44563 | 1140 | 29528809 |
Hyperphosphataemia | 18.97 | 13.47 | 20 | 44558 | 2218 | 29527731 |
Renal transplant failure | 18.93 | 13.47 | 14 | 44564 | 969 | 29528980 |
Skin fibrosis | 18.62 | 13.47 | 14 | 44564 | 993 | 29528956 |
Skin induration | 18.57 | 13.47 | 19 | 44559 | 2035 | 29527914 |
Febrile neutropenia | 18.28 | 13.47 | 97 | 44481 | 112143 | 29417806 |
Pain in extremity | 18.23 | 13.47 | 95 | 44483 | 110338 | 29419611 |
Sleep disorder | 18.16 | 13.47 | 7 | 44571 | 24379 | 29505570 |
Memory impairment | 18.04 | 13.47 | 17 | 44561 | 36453 | 29493496 |
Disturbance in attention | 17.97 | 13.47 | 5 | 44573 | 21419 | 29508530 |
Insomnia | 17.85 | 13.47 | 71 | 44507 | 88690 | 29441259 |
Toe amputation | 17.81 | 13.47 | 19 | 44559 | 2136 | 29527813 |
Arteriovenous fistula occlusion | 17.68 | 13.47 | 7 | 44571 | 134 | 29529815 |
Delirium | 17.64 | 13.47 | 20 | 44558 | 39377 | 29490572 |
Erectile dysfunction | 17.54 | 13.47 | 3 | 44575 | 18006 | 29511943 |
Depressed level of consciousness | 17.37 | 13.47 | 18 | 44560 | 36924 | 29493025 |
Blood product transfusion dependent | 17.36 | 13.47 | 9 | 44569 | 329 | 29529620 |
Fracture | 17.29 | 13.47 | 32 | 44546 | 6021 | 29523928 |
Reticulocyte count abnormal | 17 | 13.47 | 4 | 44574 | 10 | 29529939 |
Visual impairment | 16.99 | 13.47 | 12 | 44566 | 29696 | 29500253 |
Serotonin syndrome | 16.88 | 13.47 | 3 | 44575 | 17509 | 29512440 |
Dyspnoea | 16.85 | 13.47 | 370 | 44208 | 326362 | 29203587 |
Benign neoplasm | 16.82 | 13.47 | 7 | 44571 | 153 | 29529796 |
Pneumonia | 16.65 | 13.47 | 614 | 43964 | 319558 | 29210391 |
Cardiac valve disease | 16.64 | 13.47 | 21 | 44557 | 2827 | 29527122 |
Electrocardiogram QT prolonged | 16.55 | 13.47 | 18 | 44560 | 36119 | 29493830 |
Oedema due to renal disease | 16.50 | 13.47 | 3 | 44575 | 0 | 29529949 |
Inadequate osteointegration | 16.47 | 13.47 | 4 | 44574 | 12 | 29529937 |
Vision blurred | 16.30 | 13.47 | 22 | 44556 | 40154 | 29489795 |
Abdominal pain upper | 16.29 | 13.47 | 43 | 44535 | 60950 | 29468999 |
Fall | 16.20 | 13.47 | 365 | 44213 | 176813 | 29353136 |
Coronary artery disease | 16.17 | 13.47 | 26 | 44552 | 44164 | 29485785 |
Arteriovenous fistula site haemorrhage | 16.03 | 13.47 | 6 | 44572 | 98 | 29529851 |
Abdominal discomfort | 15.88 | 13.47 | 30 | 44548 | 47873 | 29482076 |
Heart rate decreased | 15.70 | 13.47 | 9 | 44569 | 24903 | 29505046 |
Skin tightness | 15.68 | 13.47 | 17 | 44561 | 1947 | 29528002 |
Coma | 15.60 | 13.47 | 22 | 44556 | 39428 | 29490521 |
Depressed mood | 15.46 | 13.47 | 3 | 44575 | 16445 | 29513504 |
Blood bilirubin increased | 15.40 | 13.47 | 17 | 44561 | 33876 | 29496073 |
Hepatotoxicity | 15.31 | 13.47 | 4 | 44574 | 17863 | 29512086 |
Mucosal inflammation | 15.31 | 13.47 | 15 | 44563 | 31580 | 29498369 |
Serum ferritin increased | 15.28 | 13.47 | 29 | 44549 | 5559 | 29524390 |
Haematochezia | 15.26 | 13.47 | 20 | 44558 | 36963 | 29492986 |
Encephalomalacia | 15.12 | 13.47 | 11 | 44567 | 742 | 29529207 |
Abnormal behaviour | 15.09 | 13.47 | 8 | 44570 | 23119 | 29506830 |
Dry mouth | 15.02 | 13.47 | 7 | 44571 | 21777 | 29508172 |
Anti-erythropoietin antibody negative | 14.96 | 13.47 | 7 | 44571 | 204 | 29529745 |
Heart valve operation | 14.84 | 13.47 | 5 | 44573 | 59 | 29529890 |
Hypoaesthesia | 14.81 | 13.47 | 37 | 44541 | 53430 | 29476519 |
Blood potassium increased | 14.63 | 13.47 | 52 | 44526 | 14599 | 29515350 |
Dysgeusia | 14.57 | 13.47 | 8 | 44570 | 22666 | 29507283 |
Enterocolitis viral | 14.54 | 13.47 | 5 | 44573 | 63 | 29529886 |
Skin hypertrophy | 14.48 | 13.47 | 18 | 44560 | 2385 | 29527564 |
Hepatic function abnormal | 14.46 | 13.47 | 23 | 44555 | 39236 | 29490713 |
Arteriovenous graft thrombosis | 14.42 | 13.47 | 3 | 44575 | 3 | 29529946 |
Dental restoration failure | 14.25 | 13.47 | 4 | 44574 | 24 | 29529925 |
Abdominal distension | 14.20 | 13.47 | 118 | 44460 | 45793 | 29484156 |
Acute kidney injury | 14.06 | 13.47 | 299 | 44279 | 264968 | 29264981 |
Diabetic complication | 14.03 | 13.47 | 10 | 44568 | 653 | 29529296 |
Dialysis device insertion | 13.98 | 13.47 | 4 | 44574 | 26 | 29529923 |
Hepatitis | 13.84 | 13.47 | 7 | 44571 | 20776 | 29509173 |
Seizure | 13.79 | 13.47 | 83 | 44495 | 93040 | 29436909 |
Fatigue | 13.79 | 13.47 | 368 | 44210 | 316453 | 29213496 |
Wheezing | 13.69 | 13.47 | 18 | 44560 | 33222 | 29496727 |
Kidney infection | 13.68 | 13.47 | 25 | 44553 | 4658 | 29525291 |
Gallbladder disorder | 13.68 | 13.47 | 28 | 44550 | 5672 | 29524277 |
Abdominal wall haemorrhage | 13.67 | 13.47 | 7 | 44571 | 249 | 29529700 |
Malignant neoplasm progression | 13.66 | 13.47 | 61 | 44517 | 73798 | 29456151 |
Loss of personal independence in daily activities | 13.62 | 13.47 | 11 | 44567 | 25429 | 29504520 |
Bradycardia | 13.51 | 13.47 | 52 | 44526 | 65577 | 29464372 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Death | 16628.62 | 12.50 | 8271 | 53052 | 474434 | 63962975 |
Hospitalisation | 6291.10 | 12.50 | 2440 | 58883 | 72767 | 64364642 |
Investigation | 2084.10 | 12.50 | 473 | 60850 | 1779 | 64435630 |
Aplasia pure red cell | 1453.60 | 12.50 | 450 | 60873 | 6564 | 64430845 |
Arteriovenous fistula site complication | 1194.67 | 12.50 | 255 | 61068 | 661 | 64436748 |
Haemodialysis | 947.57 | 12.50 | 415 | 60908 | 16662 | 64420747 |
Dialysis | 460.66 | 12.50 | 253 | 61070 | 16667 | 64420742 |
Transplant | 432.74 | 12.50 | 111 | 61212 | 767 | 64436642 |
Shunt stenosis | 392.56 | 12.50 | 107 | 61216 | 960 | 64436449 |
Haemoglobin abnormal | 359.32 | 12.50 | 154 | 61169 | 5850 | 64431559 |
Haemoglobin decreased | 339.88 | 12.50 | 640 | 60683 | 194423 | 64242986 |
Shunt occlusion | 289.36 | 12.50 | 87 | 61236 | 1140 | 64436269 |
Peritoneal dialysis | 245.05 | 12.50 | 68 | 61255 | 656 | 64436753 |
Terminal state | 208.13 | 12.50 | 96 | 61227 | 4348 | 64433061 |
Drug ineffective | 202.20 | 12.50 | 305 | 61018 | 839942 | 63597467 |
Renal transplant | 186.94 | 12.50 | 73 | 61250 | 2175 | 64435234 |
Appendicolith | 175.26 | 12.50 | 79 | 61244 | 3390 | 64434019 |
Completed suicide | 170.08 | 12.50 | 11 | 61312 | 224403 | 64213006 |
Headache | 159.82 | 12.50 | 161 | 61162 | 529306 | 63908103 |
Anti-erythropoietin antibody positive | 158.66 | 12.50 | 48 | 61275 | 643 | 64436766 |
Transfusion | 156.97 | 12.50 | 133 | 61190 | 17861 | 64419548 |
Anaemia | 148.58 | 12.50 | 732 | 60591 | 377948 | 64059461 |
Toxicity to various agents | 141.94 | 12.50 | 85 | 61238 | 363428 | 64073981 |
Renal disorder | 139.27 | 12.50 | 170 | 61153 | 35195 | 64402214 |
Transformation to acute myeloid leukaemia | 136.14 | 12.50 | 45 | 61278 | 816 | 64436593 |
Arteriovenous fistula operation | 127.12 | 12.50 | 35 | 61288 | 327 | 64437082 |
Arthralgia | 118.55 | 12.50 | 148 | 61175 | 442112 | 63995297 |
Azotaemia | 118.15 | 12.50 | 79 | 61244 | 7423 | 64429986 |
Joint swelling | 115.50 | 12.50 | 31 | 61292 | 215351 | 64222058 |
Rheumatoid arthritis | 108.60 | 12.50 | 14 | 61309 | 164280 | 64273129 |
Drug intolerance | 102.80 | 12.50 | 26 | 61297 | 187966 | 64249443 |
Product use issue | 102.55 | 12.50 | 12 | 61311 | 151703 | 64285706 |
Drug hypersensitivity | 100.91 | 12.50 | 50 | 61273 | 237765 | 64199644 |
Myelodysplastic syndrome | 94.96 | 12.50 | 124 | 61199 | 27455 | 64409954 |
Cardiac failure | 93.78 | 12.50 | 308 | 61015 | 132065 | 64305344 |
Infusion related reaction | 93.36 | 12.50 | 21 | 61302 | 164446 | 64272963 |
Chronic kidney disease | 93.18 | 12.50 | 184 | 61139 | 57735 | 64379674 |
Nephrogenic systemic fibrosis | 92.68 | 12.50 | 62 | 61261 | 5830 | 64431579 |
Appendicitis | 90.09 | 12.50 | 86 | 61237 | 13483 | 64423926 |
Contraindicated product administered | 89.01 | 12.50 | 3 | 61320 | 107826 | 64329583 |
Condition aggravated | 86.44 | 12.50 | 138 | 61185 | 372288 | 64065121 |
Sepsis | 84.99 | 12.50 | 438 | 60885 | 229903 | 64207506 |
Rehabilitation therapy | 84.95 | 12.50 | 37 | 61286 | 1461 | 64435948 |
Haemoglobin increased | 84.88 | 12.50 | 56 | 61267 | 5145 | 64432264 |
Peritonitis | 80.75 | 12.50 | 109 | 61214 | 24914 | 64412495 |
Renal impairment | 80.73 | 12.50 | 297 | 61026 | 134720 | 64302689 |
Sinusitis | 80.12 | 12.50 | 20 | 61303 | 145908 | 64291501 |
Pain | 78.64 | 12.50 | 267 | 61056 | 553244 | 63884165 |
End stage renal disease | 78.45 | 12.50 | 71 | 61252 | 10404 | 64427005 |
Mineral supplementation | 77.82 | 12.50 | 29 | 61294 | 758 | 64436651 |
Angina pectoris | 74.67 | 12.50 | 145 | 61178 | 44936 | 64392473 |
Alopecia | 74.66 | 12.50 | 32 | 61291 | 165658 | 64271751 |
Hip fracture | 74.04 | 12.50 | 109 | 61214 | 26990 | 64410419 |
Neoplasm malignant | 71.38 | 12.50 | 102 | 61221 | 24586 | 64412823 |
Palliative care | 70.48 | 12.50 | 26 | 61297 | 660 | 64436749 |
Arteriovenous fistula site infection | 70.45 | 12.50 | 19 | 61304 | 163 | 64437246 |
Hepatic enzyme increased | 69.06 | 12.50 | 19 | 61304 | 129924 | 64307485 |
Weight increased | 68.71 | 12.50 | 61 | 61262 | 213287 | 64224122 |
Arthropathy | 67.53 | 12.50 | 16 | 61307 | 120951 | 64316458 |
Therapeutic response decreased | 66.75 | 12.50 | 151 | 61172 | 52037 | 64385372 |
Drug interaction | 65.87 | 12.50 | 155 | 61168 | 361928 | 64075481 |
Hypervolaemia | 64.45 | 12.50 | 124 | 61199 | 38161 | 64399248 |
Somnolence | 62.31 | 12.50 | 61 | 61262 | 203584 | 64233825 |
Reticulocyte count decreased | 62.09 | 12.50 | 24 | 61299 | 695 | 64436714 |
Marasmus | 61.10 | 12.50 | 25 | 61298 | 843 | 64436566 |
Intermittent claudication | 60.08 | 12.50 | 37 | 61286 | 3017 | 64434392 |
Hypersensitivity | 59.92 | 12.50 | 59 | 61264 | 196393 | 64241016 |
Refractory cytopenia with unilineage dysplasia | 58.47 | 12.50 | 24 | 61299 | 816 | 64436593 |
Hepatic cyst infection | 58.25 | 12.50 | 16 | 61307 | 148 | 64437261 |
Arteriovenous fistula thrombosis | 57.87 | 12.50 | 21 | 61302 | 508 | 64436901 |
Abdominal discomfort | 56.48 | 12.50 | 54 | 61269 | 182268 | 64255141 |
Product use in unapproved indication | 56.26 | 12.50 | 51 | 61272 | 176567 | 64260842 |
Suicide attempt | 55.20 | 12.50 | 3 | 61320 | 71004 | 64366405 |
Systemic lupus erythematosus | 52.77 | 12.50 | 6 | 61317 | 77606 | 64359803 |
Suicidal ideation | 51.15 | 12.50 | 3 | 61320 | 66539 | 64370870 |
Dizziness | 50.41 | 12.50 | 224 | 61099 | 429939 | 64007470 |
Treatment failure | 50.36 | 12.50 | 24 | 61299 | 116792 | 64320617 |
Renal failure | 50.21 | 12.50 | 320 | 61003 | 181368 | 64256041 |
Pneumonia | 50.19 | 12.50 | 778 | 60545 | 558798 | 63878611 |
Peripheral swelling | 49.88 | 12.50 | 76 | 61247 | 209077 | 64228332 |
Depression | 49.34 | 12.50 | 61 | 61262 | 183230 | 64254179 |
Hyperparathyroidism secondary | 47.81 | 12.50 | 29 | 61294 | 2301 | 64435108 |
Intentional product use issue | 46.96 | 12.50 | 16 | 61307 | 95348 | 64342061 |
Renal cyst infection | 46.66 | 12.50 | 14 | 61309 | 182 | 64437227 |
Musculoskeletal stiffness | 46.34 | 12.50 | 30 | 61293 | 123176 | 64314233 |
Renal cyst haemorrhage | 45.59 | 12.50 | 17 | 61306 | 445 | 64436964 |
Anxiety | 45.16 | 12.50 | 77 | 61246 | 202572 | 64234837 |
Anti-erythropoietin antibody negative | 45.07 | 12.50 | 15 | 61308 | 278 | 64437131 |
Living in residential institution | 44.67 | 12.50 | 18 | 61305 | 583 | 64436826 |
Unevaluable event | 44.62 | 12.50 | 127 | 61196 | 50362 | 64387047 |
Ascites | 44.52 | 12.50 | 145 | 61178 | 61856 | 64375553 |
Nausea | 44.41 | 12.50 | 506 | 60817 | 785294 | 63652115 |
Reticulocyte count abnormal | 44.35 | 12.50 | 11 | 61312 | 65 | 64437344 |
Glossodynia | 43.99 | 12.50 | 5 | 61318 | 64691 | 64372718 |
Peripheral arterial occlusive disease | 43.96 | 12.50 | 43 | 61280 | 6944 | 64430465 |
Rash | 43.41 | 12.50 | 257 | 61066 | 458292 | 63979117 |
Injection site erythema | 42.30 | 12.50 | 8 | 61315 | 70792 | 64366617 |
Leg amputation | 42.10 | 12.50 | 31 | 61292 | 3396 | 64434013 |
Cardiogenic shock | 41.65 | 12.50 | 94 | 61229 | 32333 | 64405076 |
Nasopharyngitis | 41.43 | 12.50 | 77 | 61246 | 195996 | 64241413 |
Product storage error | 41.43 | 12.50 | 57 | 61266 | 13261 | 64424148 |
Pleural effusion | 40.74 | 12.50 | 232 | 61091 | 126327 | 64311082 |
Zoonotic bacterial infection | 40.48 | 12.50 | 10 | 61313 | 58 | 64437351 |
Hyperphosphataemia | 40.10 | 12.50 | 32 | 61291 | 3949 | 64433460 |
Iron overload | 38.79 | 12.50 | 22 | 61301 | 1540 | 64435869 |
Fracture | 38.22 | 12.50 | 66 | 61257 | 18689 | 64418720 |
Renal artery stenosis | 36.80 | 12.50 | 27 | 61296 | 2942 | 64434467 |
Asthma | 36.06 | 12.50 | 23 | 61300 | 95202 | 64342207 |
Plasma cell myeloma | 36.05 | 12.50 | 111 | 61212 | 45964 | 64391445 |
Alanine aminotransferase increased | 34.62 | 12.50 | 49 | 61274 | 138982 | 64298427 |
Overdose | 34.30 | 12.50 | 62 | 61261 | 159504 | 64277905 |
Fatigue | 34.18 | 12.50 | 504 | 60819 | 748226 | 63689183 |
Thrombocytopenia | 34.17 | 12.50 | 344 | 60979 | 223457 | 64213952 |
Product dose omission issue | 34.06 | 12.50 | 85 | 61238 | 194662 | 64242747 |
Multiple organ dysfunction syndrome | 34.02 | 12.50 | 188 | 61135 | 101225 | 64336184 |
Hypoaesthesia | 33.68 | 12.50 | 50 | 61273 | 139058 | 64298351 |
Pain in extremity | 33.57 | 12.50 | 161 | 61162 | 302924 | 64134485 |
Memory impairment | 33.41 | 12.50 | 20 | 61303 | 85662 | 64351747 |
Mycobacterium marinum infection | 33.20 | 12.50 | 13 | 61310 | 390 | 64437019 |
Therapeutic product effect incomplete | 32.79 | 12.50 | 30 | 61293 | 103452 | 64333957 |
Renal transplant failure | 32.59 | 12.50 | 20 | 61303 | 1620 | 64435789 |
Hyperhidrosis | 32.13 | 12.50 | 43 | 61280 | 124877 | 64312532 |
Arthritis | 32.07 | 12.50 | 20 | 61303 | 83794 | 64353615 |
Cardiac output decreased | 31.89 | 12.50 | 20 | 61303 | 1684 | 64435725 |
Cough | 31.46 | 12.50 | 164 | 61159 | 301984 | 64135425 |
Blood cholesterol increased | 31.35 | 12.50 | 5 | 61318 | 50061 | 64387348 |
Hyperparathyroidism | 31.05 | 12.50 | 24 | 61299 | 2828 | 64434581 |
Visual impairment | 30.74 | 12.50 | 16 | 61307 | 74061 | 64363348 |
Skin induration | 30.67 | 12.50 | 28 | 61295 | 4147 | 64433262 |
Diabetic complication | 30.67 | 12.50 | 17 | 61306 | 1138 | 64436271 |
Migraine | 30.03 | 12.50 | 11 | 61312 | 62666 | 64374743 |
Transferrin saturation increased | 29.78 | 12.50 | 9 | 61314 | 120 | 64437289 |
Delayed graft function | 29.72 | 12.50 | 24 | 61299 | 3012 | 64434397 |
Arteriovenous fistula occlusion | 29.32 | 12.50 | 13 | 61310 | 536 | 64436873 |
Shunt infection | 29.12 | 12.50 | 9 | 61314 | 130 | 64437279 |
Swelling | 28.74 | 12.50 | 69 | 61254 | 160149 | 64277260 |
Skin hypertrophy | 28.73 | 12.50 | 28 | 61295 | 4501 | 64432908 |
Erythropoiesis abnormal | 28.70 | 12.50 | 12 | 61311 | 428 | 64436981 |
Arteriovenous fistula site haemorrhage | 28.54 | 12.50 | 11 | 61312 | 316 | 64437093 |
Vena cava injury | 28.45 | 12.50 | 10 | 61313 | 220 | 64437189 |
Gangrene | 28.43 | 12.50 | 35 | 61288 | 7303 | 64430106 |
Cardiac failure congestive | 28.39 | 12.50 | 217 | 61106 | 130363 | 64307046 |
Intraductal papillary mucinous neoplasm | 28.28 | 12.50 | 13 | 61310 | 584 | 64436825 |
Insomnia | 28.27 | 12.50 | 95 | 61228 | 197741 | 64239668 |
Pericarditis | 28.26 | 12.50 | 12 | 61311 | 62504 | 64374905 |
Loss of personal independence in daily activities | 28.12 | 12.50 | 17 | 61306 | 72437 | 64364972 |
Sleep disorder | 27.73 | 12.50 | 11 | 61312 | 59698 | 64377711 |
SARS-CoV-2 antibody test positive | 27.67 | 12.50 | 10 | 61313 | 239 | 64437170 |
Discomfort | 27.39 | 12.50 | 22 | 61301 | 80856 | 64356553 |
Cardiac valve disease | 27.28 | 12.50 | 29 | 61294 | 5166 | 64432243 |
Blood parathyroid hormone increased | 26.99 | 12.50 | 23 | 61300 | 3111 | 64434298 |
Hallucination | 26.99 | 12.50 | 18 | 61305 | 72770 | 64364639 |
Serotonin syndrome | 26.79 | 12.50 | 3 | 61320 | 39279 | 64398130 |
Agitation | 26.39 | 12.50 | 27 | 61296 | 88340 | 64349069 |
Tachycardia | 26.37 | 12.50 | 65 | 61258 | 149514 | 64287895 |
Sedation | 26.28 | 12.50 | 4 | 61319 | 41458 | 64395951 |
Depressed mood | 25.89 | 12.50 | 4 | 61319 | 41008 | 64396401 |
Myalgia | 25.63 | 12.50 | 72 | 61251 | 158545 | 64278864 |
Therapeutic product effect decreased | 25.52 | 12.50 | 44 | 61279 | 115307 | 64322102 |
Procalcitonin abnormal | 25.38 | 12.50 | 10 | 61313 | 305 | 64437104 |
Flushing | 24.68 | 12.50 | 23 | 61300 | 78625 | 64358784 |
Anti-erythropoietin antibody | 24.31 | 12.50 | 5 | 61318 | 10 | 64437399 |
Iron deficiency | 24.28 | 12.50 | 32 | 61291 | 7145 | 64430264 |
Angiodysplasia | 24.23 | 12.50 | 13 | 61310 | 816 | 64436593 |
Injection site swelling | 24.02 | 12.50 | 5 | 61318 | 41348 | 64396061 |
Home care | 23.84 | 12.50 | 4 | 61319 | 0 | 64437409 |
Gait disturbance | 23.70 | 12.50 | 84 | 61239 | 172071 | 64265338 |
Oropharyngeal pain | 23.45 | 12.50 | 30 | 61293 | 88837 | 64348572 |
Nasal congestion | 23.15 | 12.50 | 14 | 61309 | 59644 | 64377765 |
Duodenal ulcer perforation | 22.74 | 12.50 | 3 | 61320 | 34622 | 64402787 |
Tremor | 22.70 | 12.50 | 69 | 61254 | 148161 | 64289248 |
Blood erythropoietin increased | 22.64 | 12.50 | 5 | 61318 | 16 | 64437393 |
Blood potassium increased | 22.61 | 12.50 | 65 | 61258 | 25915 | 64411494 |
Psoriasis | 22.46 | 12.50 | 21 | 61302 | 71682 | 64365727 |
Dry mouth | 22.32 | 12.50 | 15 | 61308 | 60403 | 64377006 |
Haemodialysis complication | 22.21 | 12.50 | 9 | 61314 | 296 | 64437113 |
Skin fibrosis | 22.10 | 12.50 | 15 | 61308 | 1444 | 64435965 |
Gastrointestinal disorder | 21.94 | 12.50 | 32 | 61291 | 89677 | 64347732 |
Metastatic neoplasm | 21.93 | 12.50 | 24 | 61299 | 4418 | 64432991 |
Premature delivery | 21.80 | 12.50 | 52 | 61271 | 18537 | 64418872 |
Osteoarthritis | 21.73 | 12.50 | 17 | 61306 | 63319 | 64374090 |
Coma | 21.68 | 12.50 | 31 | 61292 | 87584 | 64349825 |
Serum ferritin increased | 21.61 | 12.50 | 33 | 61290 | 8435 | 64428974 |
Weight decreased | 21.59 | 12.50 | 171 | 61152 | 285568 | 64151841 |
Skin tightness | 21.41 | 12.50 | 25 | 61298 | 4936 | 64432473 |
Peritonitis bacterial | 21.35 | 12.50 | 34 | 61289 | 9009 | 64428400 |
Feeling abnormal | 21.32 | 12.50 | 61 | 61262 | 133541 | 64303868 |
Heart rate decreased | 21.26 | 12.50 | 13 | 61310 | 55054 | 64382355 |
Abdominal pain upper | 21.14 | 12.50 | 90 | 61233 | 174940 | 64262469 |
Cardiac disorder | 21.13 | 12.50 | 107 | 61216 | 55709 | 64381700 |
Injection site pruritus | 21.11 | 12.50 | 5 | 61318 | 37821 | 64399588 |
Hepatotoxicity | 20.93 | 12.50 | 6 | 61317 | 39956 | 64397453 |
Haemorrhage | 20.81 | 12.50 | 138 | 61185 | 79213 | 64358196 |
Irritable bowel syndrome | 20.73 | 12.50 | 5 | 61318 | 37364 | 64400045 |
Irritability | 20.22 | 12.50 | 5 | 61318 | 36741 | 64400668 |
Hepatitis | 20.20 | 12.50 | 9 | 61314 | 45573 | 64391836 |
Serum ferritin abnormal | 20.03 | 12.50 | 9 | 61314 | 383 | 64437026 |
Neutralising antibodies positive | 19.86 | 12.50 | 8 | 61315 | 259 | 64437150 |
Dysgeusia | 19.76 | 12.50 | 10 | 61313 | 47037 | 64390372 |
Balance disorder | 19.50 | 12.50 | 31 | 61292 | 83895 | 64353514 |
Fibromyalgia | 19.40 | 12.50 | 5 | 61318 | 35726 | 64401683 |
Lactic acidosis | 19.22 | 12.50 | 18 | 61305 | 61392 | 64376017 |
Toe amputation | 19.20 | 12.50 | 20 | 61303 | 3480 | 64433929 |
Injection site pain | 19.18 | 12.50 | 49 | 61274 | 111359 | 64326050 |
Ischaemic stroke | 19.15 | 12.50 | 66 | 61257 | 28969 | 64408440 |
Stomatitis | 19.03 | 12.50 | 48 | 61275 | 109557 | 64327852 |
Wound | 18.98 | 12.50 | 27 | 61296 | 76450 | 64360959 |
Urticaria | 18.89 | 12.50 | 74 | 61249 | 147243 | 64290166 |
Aspartate aminotransferase increased | 18.88 | 12.50 | 55 | 61268 | 119733 | 64317676 |
Haemolysis | 18.87 | 12.50 | 36 | 61287 | 11003 | 64426406 |
Drug-induced liver injury | 18.74 | 12.50 | 11 | 61312 | 47632 | 64389777 |
Product quality issue | 18.60 | 12.50 | 3 | 61320 | 29796 | 64407613 |
Vision blurred | 18.59 | 12.50 | 36 | 61287 | 90280 | 64347129 |
Psychotic disorder | 18.47 | 12.50 | 5 | 61318 | 34573 | 64402836 |
Normochromic normocytic anaemia | 18.40 | 12.50 | 27 | 61296 | 6663 | 64430746 |
Inadequate osteointegration | 18.30 | 12.50 | 4 | 61319 | 12 | 64437397 |
Lymphocele | 18.28 | 12.50 | 14 | 61309 | 1627 | 64435782 |
Complications of transplanted kidney | 18.03 | 12.50 | 24 | 61299 | 5411 | 64431998 |
Volume blood increased | 17.88 | 12.50 | 3 | 61320 | 0 | 64437409 |
Cytomegalovirus pancreatitis | 17.88 | 12.50 | 3 | 61320 | 0 | 64437409 |
Fungal endocarditis | 17.88 | 12.50 | 9 | 61314 | 495 | 64436914 |
Blister | 17.80 | 12.50 | 31 | 61292 | 80936 | 64356473 |
Abnormal behaviour | 17.70 | 12.50 | 5 | 61318 | 33617 | 64403792 |
Blood product transfusion dependent | 17.68 | 12.50 | 8 | 61315 | 346 | 64437063 |
Parakeratosis | 17.66 | 12.50 | 8 | 61315 | 347 | 64437062 |
Eye infection bacterial | 17.60 | 12.50 | 7 | 61316 | 219 | 64437190 |
Drug ineffective for unapproved indication | 17.60 | 12.50 | 4 | 61319 | 31129 | 64406280 |
Liver function test increased | 17.47 | 12.50 | 4 | 61319 | 30966 | 64406443 |
Haematocrit decreased | 17.45 | 12.50 | 100 | 61223 | 54555 | 64382854 |
Gastroenteritis | 17.43 | 12.50 | 65 | 61258 | 29646 | 64407763 |
Natural killer cell count | 17.41 | 12.50 | 4 | 61319 | 16 | 64437393 |
Shunt malfunction | 17.37 | 12.50 | 7 | 61316 | 227 | 64437182 |
Feeling hot | 17.32 | 12.50 | 11 | 61312 | 45652 | 64391757 |
Anaphylactic reaction | 17.28 | 12.50 | 24 | 61299 | 68640 | 64368769 |
Angioedema | 17.23 | 12.50 | 20 | 61303 | 61801 | 64375608 |
Amegakaryocytic thrombocytopenia | 17.22 | 12.50 | 4 | 61319 | 17 | 64437392 |
Hypocalcaemia | 17.20 | 12.50 | 82 | 61241 | 41671 | 64395738 |
Dialysis device insertion | 17.18 | 12.50 | 5 | 61318 | 58 | 64437351 |
Influenza like illness | 17.15 | 12.50 | 20 | 61303 | 61682 | 64375727 |
Rhinorrhoea | 17.15 | 12.50 | 19 | 61304 | 59950 | 64377459 |
Hyperuricaemia | 17.14 | 12.50 | 33 | 61290 | 10158 | 64427251 |
Throat irritation | 16.97 | 12.50 | 5 | 61318 | 32706 | 64404703 |
Maternal condition affecting foetus | 16.82 | 12.50 | 6 | 61317 | 138 | 64437271 |
Folliculitis | 16.73 | 12.50 | 4 | 61319 | 30073 | 64407336 |
Hyperkalaemia | 16.66 | 12.50 | 158 | 61165 | 100971 | 64336438 |
Acute leukaemia | 16.43 | 12.50 | 13 | 61310 | 1585 | 64435824 |
Sopor | 16.39 | 12.50 | 4 | 61319 | 29657 | 64407752 |
Gastrointestinal haemorrhage | 16.31 | 12.50 | 195 | 61128 | 132117 | 64305292 |
Kidney transplant rejection | 16.24 | 12.50 | 31 | 61292 | 9480 | 64427929 |
Upper respiratory tract inflammation | 16.23 | 12.50 | 19 | 61304 | 3763 | 64433646 |
Gastric cancer | 16.14 | 12.50 | 25 | 61298 | 6468 | 64430941 |
Interstitial lung disease | 16.05 | 12.50 | 44 | 61279 | 97688 | 64339721 |
Blood test abnormal | 16.04 | 12.50 | 37 | 61286 | 12906 | 64424503 |
Encephalomalacia | 16.01 | 12.50 | 11 | 61312 | 1080 | 64436329 |
Diabetic gangrene | 15.92 | 12.50 | 6 | 61317 | 162 | 64437247 |
Haematochezia | 15.92 | 12.50 | 24 | 61299 | 66349 | 64371060 |
Upper respiratory tract infection | 15.88 | 12.50 | 28 | 61295 | 72757 | 64364652 |
Dry eye | 15.87 | 12.50 | 4 | 61319 | 29015 | 64408394 |
PO2 decreased | 15.78 | 12.50 | 16 | 61307 | 2697 | 64434712 |
Uterine atony | 15.68 | 12.50 | 6 | 61317 | 169 | 64437240 |
Dyskinesia | 15.62 | 12.50 | 9 | 61314 | 39379 | 64398030 |
Myelodysplastic syndrome transformation | 15.61 | 12.50 | 9 | 61314 | 650 | 64436759 |
Disturbance in attention | 15.44 | 12.50 | 10 | 61313 | 41064 | 64396345 |
Lung neoplasm malignant | 15.24 | 12.50 | 50 | 61273 | 21398 | 64416011 |
Electrocardiogram QT prolonged | 15.22 | 12.50 | 33 | 61290 | 79415 | 64357994 |
Reticulocytopenia | 15.14 | 12.50 | 6 | 61317 | 186 | 64437223 |
Chest discomfort | 15.09 | 12.50 | 58 | 61265 | 116048 | 64321361 |
Muscle spasms | 14.96 | 12.50 | 76 | 61247 | 140947 | 64296462 |
Oxygen saturation decreased | 14.94 | 12.50 | 52 | 61271 | 107124 | 64330285 |
PCO2 decreased | 14.88 | 12.50 | 16 | 61307 | 2886 | 64434523 |
Retinal artery occlusion | 14.88 | 12.50 | 16 | 61307 | 2887 | 64434522 |
Injection site bruising | 14.88 | 12.50 | 8 | 61315 | 36365 | 64401044 |
Nephrogenic anaemia | 14.76 | 12.50 | 17 | 61306 | 3308 | 64434101 |
Coombs test positive | 14.67 | 12.50 | 6 | 61317 | 202 | 64437207 |
Peritoneal dialysis complication | 14.56 | 12.50 | 14 | 61309 | 2214 | 64435195 |
Urine odour abnormal | 14.52 | 12.50 | 21 | 61302 | 5115 | 64432294 |
Aneurysm | 14.44 | 12.50 | 16 | 61307 | 2986 | 64434423 |
Abdominal distension | 14.36 | 12.50 | 147 | 61176 | 95847 | 64341562 |
Dialysis related complication | 14.32 | 12.50 | 6 | 61317 | 215 | 64437194 |
Exposure during pregnancy | 14.28 | 12.50 | 33 | 61290 | 77642 | 64359767 |
General physical health deterioration | 14.17 | 12.50 | 273 | 61050 | 204152 | 64233257 |
Cognitive disorder | 14.12 | 12.50 | 19 | 61304 | 55068 | 64382341 |
Joint contracture | 14.08 | 12.50 | 14 | 61309 | 2305 | 64435104 |
Product prescribing error | 14.07 | 12.50 | 8 | 61315 | 35261 | 64402148 |
Renal lymphocele | 13.98 | 12.50 | 5 | 61318 | 116 | 64437293 |
Hot flush | 13.95 | 12.50 | 14 | 61309 | 46221 | 64391188 |
Ventricular fibrillation | 13.83 | 12.50 | 52 | 61271 | 23808 | 64413601 |
Shunt thrombosis | 13.82 | 12.50 | 5 | 61318 | 120 | 64437289 |
Cardiac arrest | 13.64 | 12.50 | 214 | 61109 | 153850 | 64283559 |
Acute myeloid leukaemia | 13.62 | 12.50 | 57 | 61266 | 27406 | 64410003 |
Extramedullary haemopoiesis | 13.55 | 12.50 | 5 | 61318 | 127 | 64437282 |
Rectal prolapse | 13.52 | 12.50 | 12 | 61311 | 1714 | 64435695 |
Abdominal wall haemorrhage | 13.37 | 12.50 | 7 | 61316 | 418 | 64436991 |
Back pain | 13.30 | 12.50 | 163 | 61160 | 250008 | 64187401 |
Thrombosis in device | 13.28 | 12.50 | 20 | 61303 | 5051 | 64432358 |
Ear infection | 13.24 | 12.50 | 3 | 61320 | 23401 | 64414008 |
Infective aneurysm | 13.24 | 12.50 | 9 | 61314 | 869 | 64436540 |
Palpitations | 13.06 | 12.50 | 53 | 61270 | 104435 | 64332974 |
Medication error | 13.04 | 12.50 | 17 | 61306 | 49949 | 64387460 |
Delirium | 13.04 | 12.50 | 29 | 61294 | 69165 | 64368244 |
Heart rate increased | 13.01 | 12.50 | 49 | 61274 | 98626 | 64338783 |
Pulmonary arterial hypertension | 12.94 | 12.50 | 4 | 61319 | 25363 | 64412046 |
Colitis ulcerative | 12.93 | 12.50 | 3 | 61320 | 23025 | 64414384 |
Benign neoplasm | 12.93 | 12.50 | 9 | 61314 | 903 | 64436506 |
Disease complication | 12.92 | 12.50 | 18 | 61305 | 4237 | 64433172 |
Abortion spontaneous | 12.76 | 12.50 | 4 | 61319 | 25139 | 64412270 |
Inappropriate schedule of product administration | 12.71 | 12.50 | 45 | 61278 | 92241 | 64345168 |
Dyspnoea | 12.60 | 12.50 | 557 | 60766 | 718117 | 63719292 |
Red blood cell sedimentation rate increased | 12.59 | 12.50 | 7 | 61316 | 31228 | 64406181 |
Coronary artery disease | 12.52 | 12.50 | 24 | 61299 | 60409 | 64377000 |
Device related infection | 12.51 | 12.50 | 60 | 61263 | 30566 | 64406843 |
None
Source | Code | Description |
---|---|---|
ATC | B03XA02 | BLOOD AND BLOOD FORMING ORGANS ANTIANEMIC PREPARATIONS OTHER ANTIANEMIC PREPARATIONS Other antianemic preparations |
FDA CS | M0007726 | Erythropoietin |
FDA PE | N0000009319 | Increased Erythroid Cell Production |
MeSH PA | D006397 | Hematinics |
MeSH PA | D006401 | Hematologic Agents |
FDA EPC | N0000175665 | Erythropoiesis-stimulating Agent |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Anemia of renal disease | indication | 234348004 | |
Anemia due to and following chemotherapy | indication | 767657005 | |
Hypertensive disorder | contraindication | 38341003 | DOID:10763 |
None
None
None
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Erythropoietin receptor | Membrane receptor | AGONIST | DRUG LABEL | DRUG LABEL |
ID | Source |
---|---|
15UQ94PT4P | UNII |
4021274 | VANDF |
C0937950 | UMLSCUI |
CHEMBL1201566 | ChEMBL_ID |
DB00012 | DRUGBANK_ID |
D000068256 | MESH_DESCRIPTOR_UI |
D03651 | KEGG_DRUG |
8073 | INN_ID |
283838 | RXNORM |
16174 | MMSL |
235606 | MMSL |
42263 | MMSL |
d04771 | MMSL |
385608005 | SNOMEDCT_US |
385610007 | SNOMEDCT_US |
009195 | NDDF |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
ARANESP | HUMAN PRESCRIPTION DRUG LABEL | 1 | 55513-002 | SOLUTION | 25 ug | INTRAVENOUS | BLA | 29 sections |
ARANESP | HUMAN PRESCRIPTION DRUG LABEL | 1 | 55513-003 | SOLUTION | 40 ug | INTRAVENOUS | BLA | 29 sections |
ARANESP | HUMAN PRESCRIPTION DRUG LABEL | 1 | 55513-004 | SOLUTION | 60 ug | INTRAVENOUS | BLA | 29 sections |
ARANESP | HUMAN PRESCRIPTION DRUG LABEL | 1 | 55513-005 | SOLUTION | 100 ug | INTRAVENOUS | BLA | 29 sections |
ARANESP | HUMAN PRESCRIPTION DRUG LABEL | 1 | 55513-006 | SOLUTION | 200 ug | INTRAVENOUS | BLA | 29 sections |
ARANESP | HUMAN PRESCRIPTION DRUG LABEL | 1 | 55513-021 | INJECTION, SOLUTION | 40 ug | INTRAVENOUS | BLA | 29 sections |
ARANESP | HUMAN PRESCRIPTION DRUG LABEL | 1 | 55513-023 | INJECTION, SOLUTION | 60 ug | INTRAVENOUS | BLA | 29 sections |
ARANESP | HUMAN PRESCRIPTION DRUG LABEL | 1 | 55513-025 | INJECTION, SOLUTION | 100 ug | INTRAVENOUS | BLA | 29 sections |
ARANESP | HUMAN PRESCRIPTION DRUG LABEL | 1 | 55513-027 | INJECTION, SOLUTION | 150 ug | INTRAVENOUS | BLA | 29 sections |
ARANESP | HUMAN PRESCRIPTION DRUG LABEL | 1 | 55513-028 | INJECTION, SOLUTION | 200 ug | INTRAVENOUS | BLA | 29 sections |
ARANESP | HUMAN PRESCRIPTION DRUG LABEL | 1 | 55513-032 | INJECTION, SOLUTION | 500 ug | INTRAVENOUS | BLA | 29 sections |
ARANESP | HUMAN PRESCRIPTION DRUG LABEL | 1 | 55513-057 | INJECTION, SOLUTION | 25 ug | INTRAVENOUS | BLA | 29 sections |
ARANESP | HUMAN PRESCRIPTION DRUG LABEL | 1 | 55513-098 | INJECTION, SOLUTION | 10 ug | INTRAVENOUS | BLA | 29 sections |
ARANESP | HUMAN PRESCRIPTION DRUG LABEL | 1 | 55513-110 | SOLUTION | 300 ug | INTRAVENOUS | BLA | 29 sections |
ARANESP | HUMAN PRESCRIPTION DRUG LABEL | 1 | 55513-111 | INJECTION, SOLUTION | 300 ug | INTRAVENOUS | BLA | 29 sections |