darbepoetin alfa 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
erythropoietin type blood factors 5157 209810-58-2

Description:

MoleculeDescription

Synonyms:

  • darbepoetin alfa
  • aranesp
acts exactly like the natural erythropoietin made by the body to stimulate red blood cell production, but it is very slightly different in its structure
  • Molecular weight:
  • Formula:
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA:
  • ALOGS:
  • ROTB: None

Drug dosage:

DoseUnitRoute
4.50 mcg P

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

None

Approvals:

DateAgencyCompanyOrphan
Sept. 17, 2001 FDA AMGEN

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Death 11946.20 13.88 5368 41368 451183 90130528
Hospitalisation 4334.76 13.88 1826 44910 126274 90455437
Investigation 1249.32 13.88 262 46474 1335 90580376
Haemodialysis 1183.17 13.88 351 46385 8396 90573315
Aplasia pure red cell 1147.60 13.88 306 46430 4888 90576823
Transplant 545.17 13.88 123 46613 926 90580785
Dialysis 544.92 13.88 209 46527 11120 90570591
Arteriovenous fistula site complication 512.52 13.88 103 46633 406 90581305
Haemoglobin decreased 421.93 13.88 467 46269 161489 90420222
Anaemia 350.47 13.88 641 46095 352161 90229550
Shunt stenosis 265.97 13.88 61 46675 498 90581213
Terminal state 258.32 13.88 84 46652 2734 90578977
Peritoneal dialysis 231.27 13.88 53 46683 431 90581280
Shunt occlusion 231.14 13.88 58 46678 717 90580994
Renal disorder 217.68 13.88 170 46566 37689 90544022
Renal impairment 211.20 13.88 266 46470 105155 90476556
Renal transplant 207.67 13.88 63 46673 1625 90580086
Drug ineffective 197.60 13.88 256 46480 1384042 89197669
Cardiac failure 193.94 13.88 260 46476 109236 90472475
Haemoglobin abnormal 179.77 13.88 83 46653 7017 90574694
Renal failure 165.16 13.88 265 46471 130742 90450969
Infusion related reaction 155.22 13.88 17 46719 416763 90164948
Rheumatoid arthritis 151.03 13.88 9 46727 362605 90219106
Contraindicated product administered 150.35 13.88 3 46733 320136 90261575
Anti-erythropoietin antibody positive 146.15 13.88 35 46701 351 90581360
Joint swelling 139.75 13.88 43 46693 503257 90078454
Arthropathy 133.69 13.88 16 46720 366226 90215485
Systemic lupus erythematosus 131.63 13.88 16 46720 361880 90219831
Glossodynia 130.97 13.88 9 46727 321770 90259941
Palliative care 130.38 13.88 38 46698 850 90580861
Therapeutic response decreased 129.14 13.88 193 46543 89536 90492175
Hepatic enzyme increased 128.66 13.88 17 46719 360719 90220992
Thrombocytopenia 123.88 13.88 308 46428 208417 90373294
Drug intolerance 121.10 13.88 40 46696 447551 90134160
Peritonitis 118.73 13.88 91 46645 19614 90562097
Transfusion 114.77 13.88 85 46651 17403 90564308
Alopecia 113.26 13.88 57 46679 495014 90086697
Product use issue 111.95 13.88 18 46718 329901 90251810
Abdominal discomfort 109.12 13.88 55 46681 477273 90104438
Intercepted product administration error 104.01 13.88 32 46704 866 90580845
Product storage error 103.76 13.88 85 46651 20156 90561555
End stage renal disease 103.56 13.88 61 46675 8510 90573201
Arthralgia 103.49 13.88 151 46585 778371 89803340
Sinusitis 103.25 13.88 25 46711 343063 90238648
Drug hypersensitivity 102.16 13.88 56 46680 463553 90118158
Unevaluable event 101.29 13.88 133 46603 54715 90526996
Arteriovenous fistula operation 101.10 13.88 24 46712 231 90581480
Wound 99.55 13.88 18 46718 302962 90278749
Headache 98.30 13.88 185 46551 862561 89719150
Myelodysplastic syndrome 97.26 13.88 83 46653 20820 90560891
Duodenal ulcer perforation 96.84 13.88 4 46732 221284 90360427
Swelling 94.69 13.88 49 46687 419009 90162702
Pain 91.16 13.88 241 46495 996100 89585611
Pericarditis 91.05 13.88 15 46721 270136 90311575
Weight increased 89.87 13.88 52 46684 417875 90163836
Treatment failure 87.89 13.88 24 46712 303904 90277807
Folliculitis 85.25 13.88 5 46731 204348 90377363
Condition aggravated 84.59 13.88 110 46626 595435 89986276
Irritable bowel syndrome 83.80 13.88 6 46730 207442 90374269
Hypersensitivity 80.14 13.88 70 46666 454607 90127104
Body mass index abnormal 79.98 13.88 25 46711 714 90580997
Nephrogenic systemic fibrosis 79.66 13.88 40 46696 4068 90577643
Type 2 diabetes mellitus 78.97 13.88 7 46729 203237 90378474
Discomfort 78.68 13.88 22 46714 274313 90307398
Nasopharyngitis 77.58 13.88 58 46678 407046 90174665
Mineral supplementation 75.15 13.88 24 46712 736 90580975
Chronic kidney disease 75.12 13.88 110 46626 50081 90531630
Hip fracture 73.50 13.88 88 46648 32989 90548722
Serositis 73.12 13.88 27 46709 1290 90580421
Musculoskeletal stiffness 72.60 13.88 31 46705 296501 90285210
Azotaemia 72.44 13.88 41 46695 5307 90576404
Urinary tract infection 71.79 13.88 330 46406 305302 90276409
Liver injury 71.67 13.88 4 46732 170563 90411148
Sepsis 69.15 13.88 227 46509 179587 90402124
Occupational exposure to product 68.51 13.88 31 46705 2500 90579211
Transformation to acute myeloid leukaemia 67.19 13.88 19 46717 380 90581331
Haemoglobin increased 66.97 13.88 44 46692 7437 90574274
Therapeutic product effect decreased 66.40 13.88 30 46706 277541 90304170
Pleural effusion 66.09 13.88 165 46571 111826 90469885
Blood creatinine increased 65.84 13.88 155 46581 101231 90480480
Central nervous system lupus 65.00 13.88 25 46711 1338 90580373
Impaired healing 64.92 13.88 20 46716 234179 90347532
Hyperkalaemia 64.15 13.88 118 46618 64846 90516865
Premature delivery 63.96 13.88 89 46647 38673 90543038
Psoriasis 63.55 13.88 3 46733 147751 90433960
Rehabilitation therapy 62.53 13.88 27 46709 1947 90579764
Peripheral swelling 62.06 13.88 73 46663 413033 90168678
Refractory cytopenia with unilineage dysplasia 61.28 13.88 19 46717 528 90581183
Product use in unapproved indication 60.14 13.88 51 46685 336185 90245526
Fall 59.74 13.88 439 46297 481371 90100340
Reticulocyte count decreased 59.63 13.88 18 46718 456 90581255
Gout 58.90 13.88 57 46679 16802 90564909
Blister 58.77 13.88 29 46707 254969 90326742
Sleep disorder 58.43 13.88 15 46721 198015 90383696
Gastrointestinal disorder 57.95 13.88 30 46706 256657 90325054
Hyperphosphataemia 57.26 13.88 31 46705 3680 90578031
Hypervolaemia 56.74 13.88 77 46659 32680 90549031
Intentional product use issue 54.16 13.88 22 46714 216870 90364841
Marasmus 53.66 13.88 19 46717 804 90580907
Cardiac output decreased 53.29 13.88 20 46716 1000 90580711
Migraine 53.23 13.88 16 46720 190376 90391335
Bursitis 52.61 13.88 4 46732 131650 90450061
Blood cholesterol increased 52.10 13.88 21 46715 207991 90373720
Pancytopenia 51.87 13.88 158 46578 120105 90461606
Rash 51.82 13.88 223 46513 795877 89785834
Asthma 50.78 13.88 31 46705 242129 90339582
Plasma cell myeloma 50.58 13.88 82 46654 40746 90540965
Dehydration 50.17 13.88 216 46520 194231 90387480
Lupus nephritis 49.65 13.88 31 46705 4801 90576910
Wheezing 47.84 13.88 32 46704 238048 90343663
Injury 47.70 13.88 21 46715 197328 90384383
Osteoarthritis 47.04 13.88 21 46715 195709 90386002
Leukopenia 46.93 13.88 136 46600 100574 90481137
Toxicity to various agents 46.36 13.88 48 46688 287798 90293913
Memory impairment 46.10 13.88 22 46714 197222 90384489
Bone marrow failure 45.88 13.88 69 46667 32152 90549559
Blood parathyroid hormone increased 45.61 13.88 26 46710 3411 90578300
Hemianopia 45.52 13.88 22 46714 2060 90579651
Cardiac disorder 44.86 13.88 94 46642 56778 90524933
Completed suicide 44.73 13.88 10 46726 145048 90436663
Haemodialysis complication 43.68 13.88 12 46724 215 90581496
Haematuria 43.05 13.88 70 46666 34867 90546844
Arteriovenous fistula site infection 43.03 13.88 9 46727 45 90581666
Obesity 42.74 13.88 3 46733 105504 90476207
Urticaria 42.06 13.88 60 46676 312674 90269037
Analgesic therapy 41.87 13.88 15 46721 657 90581054
Depression 41.09 13.88 57 46679 300544 90281167
Therapeutic product effect incomplete 40.40 13.88 25 46711 193871 90387840
Pneumonia 40.28 13.88 504 46232 637555 89944156
Shunt infection 40.20 13.88 10 46726 119 90581592
Antacid therapy 40.18 13.88 15 46721 739 90580972
Appendicolith 40.05 13.88 15 46721 746 90580965
Anti-erythropoietin antibody negative 39.97 13.88 10 46726 122 90581589
Hepatic cyst infection 39.67 13.88 10 46726 126 90581585
Drug therapy 39.15 13.88 15 46721 794 90580917
Anticoagulant therapy 39.01 13.88 15 46721 802 90580909
Prescribed overdose 38.91 13.88 3 46733 97622 90484089
Iron deficiency 38.38 13.88 35 46701 9577 90572134
Living in residential institution 38.01 13.88 14 46722 664 90581047
Hypoaesthesia 37.76 13.88 65 46671 314145 90267566
Blood phosphorus increased 37.69 13.88 25 46711 4293 90577418
Neutropenia 37.59 13.88 221 46515 224683 90357028
Cellulitis 37.52 13.88 118 46618 91219 90490492
Arthritis 37.09 13.88 20 46716 167295 90414416
Drug specific antibody absent 35.96 13.88 9 46727 110 90581601
Iron overload 35.72 13.88 15 46721 1010 90580701
Renal cyst infection 34.96 13.88 9 46727 124 90581587
Hypocalcaemia 34.55 13.88 71 46665 42297 90539414
Disease progression 34.44 13.88 166 46570 156449 90425262
Blood test abnormal 34.40 13.88 48 46688 20904 90560807
Ill-defined disorder 34.33 13.88 27 46709 184864 90396847
Injection site erythema 34.23 13.88 5 46731 98497 90483214
Neoplasm malignant 34.02 13.88 62 46674 33818 90547893
Insomnia 34.01 13.88 76 46660 333398 90248313
Pulmonary fibrosis 33.98 13.88 7 46729 107496 90474215
Reticulocyte count abnormal 33.79 13.88 8 46728 76 90581635
Serum ferritin increased 33.70 13.88 29 46707 7352 90574359
Diabetes mellitus 33.55 13.88 91 46645 64784 90516927
Sciatica 33.32 13.88 6 46730 101376 90480335
Dizziness 32.49 13.88 175 46561 589109 89992602
Peripheral venous disease 32.29 13.88 3 46733 83918 90497793
Night sweats 32.23 13.88 13 46723 128753 90452958
Deep vein thrombosis 31.96 13.88 112 46624 91508 90490203
Skin induration 31.20 13.88 20 46716 3242 90578469
Stomatitis 31.06 13.88 59 46677 274639 90307072
Mobility decreased 30.92 13.88 51 46685 250683 90331028
Dyspepsia 30.82 13.88 34 46702 198126 90383585
Myocardial infarction 30.68 13.88 122 46614 105850 90475861
Cardiac failure congestive 30.50 13.88 116 46620 98578 90483133
Anti-erythropoietin antibody 30.50 13.88 5 46731 3 90581708
Joint range of motion decreased 30.38 13.88 16 46720 135627 90446084
Road traffic accident 30.15 13.88 9 46727 107617 90474094
Diabetic complication 29.81 13.88 13 46723 960 90580751
Epistaxis 29.64 13.88 104 46632 85021 90496690
Knee arthroplasty 29.42 13.88 4 46732 83178 90498533
Hypercholesterolaemia 29.07 13.88 8 46728 100884 90480827
Febrile bone marrow aplasia 28.65 13.88 30 46706 9708 90572003
Inflammation 28.49 13.88 30 46706 178562 90403149
Blood erythropoietin increased 28.48 13.88 5 46731 7 90581704
Prescribed underdose 28.03 13.88 3 46733 75016 90506695
Loss of personal independence in daily activities 27.72 13.88 18 46718 136087 90445624
Product quality issue 27.62 13.88 4 46732 79321 90502390
Blood potassium increased 27.52 13.88 43 46693 20706 90561005
Suicidal ideation 27.48 13.88 3 46733 73852 90507859
Cerebral infarction 27.12 13.88 49 46687 26547 90555164
Dry mouth 27.09 13.88 33 46703 184026 90397685
Blood uric acid increased 26.82 13.88 26 46710 7678 90574033
Illness 26.61 13.88 5 46731 81964 90499747
Essential thrombocythaemia 26.53 13.88 8 46728 202 90581509
Cerebrovascular accident 26.48 13.88 130 46606 123403 90458308
Haemolysis 26.45 13.88 27 46709 8483 90573228
Transplant failure 26.41 13.88 15 46721 1954 90579757
Visual impairment 26.29 13.88 18 46718 132347 90449364
Home care 26.28 13.88 4 46732 0 90581711
Wound infection 26.21 13.88 11 46725 106391 90475320
Kidney transplant rejection 26.16 13.88 21 46715 4836 90576875
Fungal endocarditis 25.95 13.88 9 46727 358 90581353
Maternal condition affecting foetus 25.78 13.88 8 46728 223 90581488
Ascites 25.73 13.88 68 46668 47672 90534039
Platelet count decreased 25.11 13.88 138 46598 136831 90444880
Cardiac arrest 25.10 13.88 114 46622 104821 90476890
Blood calcium increased 25.03 13.88 31 46705 12027 90569684
Arteriovenous fistula thrombosis 24.76 13.88 8 46728 255 90581456
Anxiety 24.49 13.88 80 46656 309692 90272019
Angina pectoris 24.47 13.88 59 46677 39101 90542610
Device related infection 24.40 13.88 46 46690 25740 90555971
Infective aneurysm 24.39 13.88 9 46727 429 90581282
Gait inability 24.04 13.88 24 46712 146432 90435279
Leg amputation 24.03 13.88 15 46721 2322 90579389
Calciphylaxis 23.48 13.88 17 46719 3359 90578352
Thrombosis 23.38 13.88 87 46649 73164 90508547
Live birth 23.31 13.88 6 46730 79101 90502610
Pain in extremity 23.07 13.88 137 46599 450392 90131319
Red blood cell sedimentation rate increased 22.97 13.88 7 46729 82588 90499123
Gait disturbance 22.94 13.88 64 46672 260432 90321279
Fracture 22.93 13.88 41 46695 22035 90559676
Activated partial thromboplastin time prolonged 22.83 13.88 24 46712 7801 90573910
Oedema peripheral 22.80 13.88 218 46518 257697 90324014
Drug-induced liver injury 22.80 13.88 9 46727 90309 90491402
Proteinuria 22.60 13.88 42 46694 23249 90558462
Skin hypertrophy 22.46 13.88 17 46719 3593 90578118
Hyperparathyroidism secondary 22.24 13.88 13 46723 1788 90579923
Liver function test increased 22.18 13.88 8 46728 84847 90496864
Medication error 22.09 13.88 8 46728 84644 90497067
Haemorrhage 21.82 13.88 82 46654 69287 90512424
Adverse drug reaction 21.71 13.88 17 46719 116684 90465027
Drug interaction 21.43 13.88 72 46664 276381 90305330
Foetal growth restriction 20.91 13.88 25 46711 9355 90572356
Peripheral arterial occlusive disease 20.78 13.88 18 46718 4603 90577108
Urine odour abnormal 20.75 13.88 22 46714 7222 90574489
Hyperuricaemia 20.31 13.88 21 46715 6698 90575013
Ischaemic stroke 20.30 13.88 39 46697 22127 90559584
Product dose omission issue 19.96 13.88 80 46656 291607 90290104
Nasal congestion 19.95 13.88 9 46727 83405 90498306
Caesarean section 19.94 13.88 35 46701 18542 90563169
Natural killer cell count 19.85 13.88 4 46732 16 90581695
Amegakaryocytic thrombocytopenia 19.85 13.88 4 46732 16 90581695
Eye infection bacterial 19.62 13.88 7 46729 303 90581408
Aortic stenosis 19.51 13.88 20 46716 6316 90575395
Intermittent claudication 19.50 13.88 12 46724 1811 90579900
Gastrooesophageal reflux disease 19.43 13.88 35 46701 166302 90415409
Hyperparathyroidism 19.20 13.88 15 46721 3322 90578389
Skin ulcer 19.03 13.88 63 46673 50012 90531699
Renal transplant failure 18.99 13.88 10 46726 1122 90580589
Uterine atony 18.83 13.88 7 46729 341 90581370
Parakeratosis 18.79 13.88 7 46729 343 90581368
Blood product transfusion dependent 18.73 13.88 6 46730 186 90581525
Macrophages increased 18.66 13.88 4 46732 23 90581688
Gastrointestinal haemorrhage 18.65 13.88 94 46642 90154 90491557
Arteriovenous fistula occlusion 18.39 13.88 7 46729 364 90581347
Polycythaemia 18.27 13.88 10 46726 1213 90580498
Skin fibrosis 18.26 13.88 9 46727 879 90580832
Reticulocytopenia 18.02 13.88 5 46731 93 90581618
Nausea 17.97 13.88 436 46300 1109880 89471831
Hepatitis 17.93 13.88 7 46729 70732 90510979
Dry eye 17.84 13.88 4 46732 57927 90523784
Joint stiffness 17.78 13.88 9 46727 78033 90503678
Contusion 17.76 13.88 68 46668 251148 90330563
Pyelonephritis 17.71 13.88 36 46700 21280 90560431
Extramedullary haemopoiesis 17.64 13.88 6 46730 225 90581486
Vascular shunt 17.63 13.88 3 46733 3 90581708
Subdural haematoma 17.40 13.88 31 46705 16614 90565097
Arteriovenous fistula site haemorrhage 17.34 13.88 6 46730 237 90581474
Skin tightness 17.25 13.88 16 46720 4472 90577239
Dialysis related complication 17.23 13.88 5 46731 110 90581601
Serum ferritin abnormal 17.20 13.88 6 46730 243 90581468
Peritonitis bacterial 17.16 13.88 17 46719 5154 90576557
Myelodysplastic syndrome transformation 17.06 13.88 7 46729 444 90581267
Premature baby 16.99 13.88 39 46697 25038 90556673
Eyelid oedema 16.85 13.88 25 46711 11509 90570202
Exposure during pregnancy 16.55 13.88 65 46671 238345 90343366
Marrow hyperplasia 16.53 13.88 8 46728 751 90580960
Nail disorder 16.43 13.88 5 46731 59062 90522649
Injection site reaction 16.40 13.88 14 46722 92066 90489645
Upper limb fracture 16.24 13.88 35 46701 21543 90560168
Haematocrit decreased 16.22 13.88 53 46683 41779 90539932
Nephrogenic anaemia 16.21 13.88 12 46724 2454 90579257
Acute myeloid leukaemia 16.14 13.88 34 46702 20606 90561105
Agranulocytosis 16.04 13.88 47 46689 34955 90546756
Injection site pruritus 16.02 13.88 4 46732 53830 90527881
Thrombosis in device 15.94 13.88 13 46723 3062 90578649
Upper respiratory tract infection 15.90 13.88 26 46710 128292 90453419
Gastric antral vascular ectasia 15.86 13.88 8 46728 821 90580890
Acute pulmonary oedema 15.80 13.88 22 46714 9558 90572153
Paraesthesia 15.68 13.88 71 46665 250255 90331456
Retinal haemorrhage 15.62 13.88 17 46719 5747 90575964
Pulmonary embolism 15.47 13.88 118 46618 130702 90451009
Renal cell carcinoma 15.33 13.88 14 46722 3837 90577874
Pemphigoid 15.30 13.88 21 46715 9005 90572706
Threatened labour 15.26 13.88 8 46728 890 90580821
Pulmonary oedema 15.26 13.88 68 46668 62012 90519699
Mycobacterial peritonitis 15.16 13.88 4 46732 61 90581650
Blister infected 15.13 13.88 8 46728 905 90580806
Peritoneal dialysis complication 15.03 13.88 9 46727 1293 90580418
Decubitus ulcer 15.00 13.88 24 46712 11789 90569922
Colon cancer 14.96 13.88 23 46713 10921 90570790
CALR gene mutation 14.89 13.88 3 46733 12 90581699
Renal lymphocele 14.87 13.88 4 46732 66 90581645
Pneumonia respiratory syncytial viral 14.73 13.88 9 46727 1342 90580369
Laryngitis 14.66 13.88 4 46732 50749 90530962
Chemotherapy 14.57 13.88 10 46726 1817 90579894
Ear infection 14.52 13.88 9 46727 69766 90511945
Haemoperitoneum 14.39 13.88 13 46723 3515 90578196
Clostridium difficile colitis 14.35 13.88 38 46698 26668 90555043
Muscle spasms 14.29 13.88 74 46662 251809 90329902
Shunt thrombosis 14.24 13.88 4 46732 78 90581633
Pelvic fracture 14.21 13.88 27 46709 15192 90566519
Haemosiderosis 14.18 13.88 5 46731 209 90581502
Urinary tract inflammation 14.15 13.88 4 46732 80 90581631
Arrhythmia 14.12 13.88 51 46685 42281 90539430
Blood urea increased 14.09 13.88 41 46695 30372 90551339
Prothrombin time prolonged 14.01 13.88 21 46715 9751 90571960
Shunt malfunction 14.01 13.88 4 46732 83 90581628
Blood iron increased 13.94 13.88 10 46726 1949 90579762

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Death 11917.71 13.69 7433 49959 463752 42100191
Hospitalisation 4344.07 13.69 2073 55319 72257 42491686
Aplasia pure red cell 1430.42 13.69 486 56906 6680 42557263
Haemodialysis 1091.30 13.69 438 56954 9822 42554121
Investigation 886.68 13.69 214 57178 721 42563222
Arteriovenous fistula site complication 704.59 13.69 157 57235 328 42563615
Dialysis 515.81 13.69 273 57119 11713 42552230
Transplant 448.65 13.69 125 57267 829 42563114
Appendicolith 298.68 13.69 200 57192 13256 42550687
Peritoneal dialysis 277.92 13.69 78 57314 533 42563410
Shunt stenosis 276.75 13.69 82 57310 695 42563248
Haemoglobin decreased 248.89 13.69 550 56842 131921 42432022
Appendicitis 232.94 13.69 205 57187 20408 42543535
Haemoglobin abnormal 227.56 13.69 118 57274 4846 42559097
Anti-erythropoietin antibody positive 204.42 13.69 67 57325 815 42563128
Shunt occlusion 167.62 13.69 60 57332 967 42562976
Renal disorder 162.82 13.69 198 57194 28782 42535161
Blood phosphorus increased 162.79 13.69 135 57257 12390 42551553
Drug ineffective 157.25 13.69 390 57002 629807 41934136
Toxicity to various agents 155.84 13.69 57 57335 229079 42334864
Cardiogenic shock 152.66 13.69 213 57179 35427 42528516
Terminal state 152.31 13.69 87 57305 4336 42559607
Hyperphosphataemia 140.27 13.69 126 57266 12878 42551065
Therapeutic response decreased 133.55 13.69 204 57188 36808 42527135
Stress 128.63 13.69 221 57171 43991 42519952
Ascites 128.01 13.69 254 57138 56424 42507519
Transfusion 123.65 13.69 107 57285 10407 42553536
Ventricular fibrillation 120.10 13.69 174 57218 29949 42533994
Drug interaction 117.44 13.69 112 57280 266887 42297056
Myasthenia gravis 106.87 13.69 120 57272 16017 42547926
Arteriovenous fistula operation 105.38 13.69 27 57365 123 42563820
Reticulocyte count decreased 103.17 13.69 38 57354 667 42563276
Analgesic therapy 98.98 13.69 77 57315 6447 42557496
Renal transplant 97.99 13.69 53 57339 2372 42561571
Blood uric acid increased 96.84 13.69 112 57280 15435 42548508
Drug therapy 93.98 13.69 74 57318 6306 42557637
Iron deficiency 92.29 13.69 93 57299 10968 42552975
Lower respiratory tract infection 92.21 13.69 184 57208 41022 42522921
Sleep disorder therapy 91.02 13.69 75 57317 6819 42557124
Transformation to acute myeloid leukaemia 89.88 13.69 39 57353 1066 42562877
End stage renal disease 89.53 13.69 111 57281 16447 42547496
Multiple organ dysfunction syndrome 87.90 13.69 309 57083 96726 42467217
Palliative care 87.61 13.69 39 57353 1135 42562808
Haemoglobin increased 80.18 13.69 62 57330 5144 42558799
Sepsis 79.92 13.69 500 56892 198834 42365109
Product storage error 79.22 13.69 86 57306 11054 42552889
Abdominal distension 78.89 13.69 244 57148 71491 42492452
Myelodysplastic syndrome 78.71 13.69 123 57269 22622 42541321
Anaemia 77.09 13.69 642 56750 279636 42284307
Hypophosphataemia 76.31 13.69 116 57276 20829 42543114
Incorrect route of product administration 72.65 13.69 123 57269 24182 42539761
Arthralgia 70.98 13.69 104 57288 205134 42358809
Peritonitis 70.45 13.69 105 57287 18528 42545415
Bacterial infection 70.34 13.69 131 57261 27748 42536195
Hip fracture 69.15 13.69 88 57304 13384 42550559
Activated partial thromboplastin time prolonged 67.99 13.69 95 57297 15808 42548135
Intentional product use issue 66.42 13.69 9 57383 71824 42492119
Nephrogenic systemic fibrosis 65.81 13.69 47 57345 3454 42560489
Hyperparathyroidism secondary 60.13 13.69 35 57357 1807 42562136
Chronic kidney disease 59.84 13.69 169 57223 47072 42516871
Product use issue 59.47 13.69 15 57377 76736 42487207
Anticoagulant therapy 59.16 13.69 49 57343 4486 42559457
Mineral supplementation 58.64 13.69 16 57376 97 42563846
Antacid therapy 57.48 13.69 49 57343 4668 42559275
General physical health deterioration 56.62 13.69 373 57019 150873 42413070
Neoplasm malignant 56.29 13.69 106 57286 22637 42541306
Neuralgia 55.54 13.69 113 57279 25534 42538409
Treatment failure 55.24 13.69 9 57383 62615 42501328
Renal cyst haemorrhage 54.97 13.69 24 57368 666 42563277
Rash 54.42 13.69 191 57201 276763 42287180
Product use in unapproved indication 54.02 13.69 104 57288 184352 42379591
Weight increased 53.88 13.69 40 57352 107943 42456000
Rectal prolapse 52.67 13.69 22 57370 546 42563397
Arteriovenous fistula thrombosis 51.87 13.69 19 57373 328 42563615
Diabetes mellitus 51.51 13.69 188 57204 59899 42504044
Azotaemia 51.47 13.69 51 57341 5893 42558050
Hyperhidrosis 51.32 13.69 29 57363 90483 42473460
Headache 51.20 13.69 159 57233 239210 42324733
Suicide attempt 50.02 13.69 3 57389 46097 42517846
Intercepted product administration error 49.80 13.69 21 57371 534 42563409
Unevaluable event 49.77 13.69 129 57263 34159 42529784
Suicidal ideation 49.74 13.69 4 57388 48157 42515786
Hyponatraemia 48.67 13.69 267 57125 101195 42462748
Depression 47.37 13.69 48 57344 111315 42452628
Swelling 47.28 13.69 172 57220 54713 42509230
Arteriovenous fistula site infection 45.92 13.69 13 57379 92 42563851
Living in residential institution 45.35 13.69 21 57371 671 42563272
Febrile neutropenia 45.12 13.69 116 57276 185587 42378356
Alanine aminotransferase increased 45.07 13.69 32 57360 88374 42475569
Aggression 44.70 13.69 4 57388 44159 42519784
Zoonotic bacterial infection 44.67 13.69 12 57380 68 42563875
Blood calcium increased 44.62 13.69 56 57336 8398 42555545
Joint swelling 44.36 13.69 18 57374 68004 42495939
Angina pectoris 43.94 13.69 120 57272 32776 42531167
Gout 43.27 13.69 108 57284 27947 42535996
Infusion related reaction 43.19 13.69 14 57378 60792 42503151
Product dose omission issue 41.81 13.69 91 57301 154274 42409669
Refractory cytopenia with unilineage dysplasia 41.05 13.69 18 57374 505 42563438
Renal artery stenosis 41.03 13.69 30 57362 2287 42561656
Delayed graft function 39.75 13.69 31 57361 2604 42561339
Blood cholesterol increased 39.21 13.69 101 57291 26640 42537303
Reticulocytopenia 39.01 13.69 13 57379 167 42563776
Thrombosis 38.89 13.69 189 57203 68322 42495621
Ulcer 38.68 13.69 75 57317 16366 42547577
Blood test abnormal 38.14 13.69 65 57327 12841 42551102
Abdominal wall haemorrhage 37.99 13.69 17 57375 501 42563442
Dry mouth 37.81 13.69 129 57263 39750 42524193
Drug ineffective for unapproved indication 37.78 13.69 8 57384 46155 42517788
Erythropoiesis abnormal 37.67 13.69 15 57377 328 42563615
Vena cava injury 37.63 13.69 15 57377 329 42563614
Drug-induced liver injury 37.33 13.69 4 57388 38269 42525674
Tachycardia 37.12 13.69 49 57343 101038 42462905
Sinusitis 37.10 13.69 9 57383 47283 42516660
Hallucination 36.24 13.69 16 57376 57491 42506452
Agitation 35.89 13.69 21 57371 64293 42499650
Rehabilitation therapy 35.65 13.69 21 57371 1109 42562834
Leg amputation 35.60 13.69 29 57363 2594 42561349
Vascular anastomotic haemorrhage 35.47 13.69 14 57378 299 42563644
Anxiety 35.43 13.69 66 57326 118494 42445449
Bronchopulmonary aspergillosis allergic 35.35 13.69 37 57355 4561 42559382
SARS-CoV-2 antibody test positive 35.30 13.69 15 57377 389 42563554
Abdominal discomfort 34.86 13.69 30 57362 75225 42488718
Respiratory failure 34.31 13.69 76 57316 128056 42435887
Bacteroides infection 33.85 13.69 28 57364 2559 42561384
Home care 33.67 13.69 6 57386 0 42563943
Hepatic enzyme increased 33.49 13.69 10 57382 45774 42518169
Rheumatoid arthritis 33.44 13.69 8 57384 42432 42521511
Weight decreased 32.89 13.69 156 57236 207792 42356151
Congenital hiatus hernia 32.75 13.69 41 57351 6133 42557810
Cardiac failure 32.65 13.69 251 57141 106605 42457338
Intraductal papillary mucinous neoplasm 32.49 13.69 15 57377 476 42563467
Peripheral arterial occlusive disease 32.49 13.69 43 57349 6795 42557148
Chest discomfort 32.45 13.69 23 57369 63593 42500350
Intermittent claudication 32.44 13.69 27 57365 2488 42561455
Pain in extremity 32.19 13.69 100 57292 150504 42413439
Parvovirus B19 infection 31.95 13.69 23 57369 1711 42562232
Hypervolaemia 31.52 13.69 85 57307 23040 42540903
Overdose 31.09 13.69 59 57333 105205 42458738
Rhabdomyolysis 30.54 13.69 36 57356 77983 42485960
Constipation 30.29 13.69 343 57049 161948 42401995
Lactic acidosis 29.47 13.69 12 57380 45249 42518694
Hepatic cyst infection 29.25 13.69 8 57384 49 42563894
Vascular compression 29.12 13.69 13 57379 381 42563562
Psychotic disorder 28.62 13.69 3 57389 29205 42534738
Mycobacterium marinum infection 28.26 13.69 14 57378 521 42563422
Loss of personal independence in daily activities 28.17 13.69 16 57376 49800 42514143
Angioedema 28.08 13.69 11 57381 42466 42521477
Pruritus 27.90 13.69 145 57247 188626 42375317
Perineal cyst 27.82 13.69 11 57381 236 42563707
Sedation 27.74 13.69 4 57388 30471 42533472
Mucosal inflammation 27.72 13.69 16 57376 49358 42514585
Complications of transplanted kidney 27.54 13.69 35 57357 5315 42558628
Irritability 27.28 13.69 3 57389 28125 42535818
Inappropriate schedule of product administration 27.24 13.69 55 57337 95847 42468096
Visual impairment 27.16 13.69 12 57380 43101 42520842
Aortic stenosis 27.11 13.69 45 57347 8700 42555243
Muscle spasms 26.50 13.69 47 57345 85997 42477946
Haematochezia 26.22 13.69 24 57368 58412 42505531
Procalcitonin abnormal 25.93 13.69 12 57380 383 42563560
Dizziness 25.91 13.69 213 57179 249041 42314902
Memory impairment 25.82 13.69 18 57374 50204 42513739
Catheter removal 25.80 13.69 10 57382 203 42563740
Mean cell volume increased 25.67 13.69 29 57363 3894 42560049
Pyrexia 25.31 13.69 376 57016 393666 42170277
Blood creatine phosphokinase increased 25.29 13.69 17 57375 48321 42515622
Pleural effusion 25.23 13.69 220 57172 96946 42466997
Acute respiratory distress syndrome 25.09 13.69 5 57387 30103 42533840
Diarrhoea 24.92 13.69 454 56938 460395 42103548
Troponin increased 24.92 13.69 69 57323 18993 42544950
Colitis ulcerative 24.86 13.69 3 57389 26172 42537771
Disturbance in attention 24.80 13.69 5 57387 29861 42534082
Fatigue 24.55 13.69 426 56966 435215 42128728
Serotonin syndrome 24.46 13.69 3 57389 25842 42538101
Blood 25-hydroxycholecalciferol decreased 24.34 13.69 11 57381 332 42563611
Vision blurred 24.15 13.69 22 57370 53677 42510266
Interstitial lung disease 24.03 13.69 43 57349 78419 42485524
Cognitive disorder 24.03 13.69 8 57384 34164 42529779
Cough 24.02 13.69 141 57251 177962 42385981
Gangrene 23.99 13.69 32 57360 5094 42558849
Carotid arteriosclerosis 23.97 13.69 22 57370 2310 42561633
Marasmus 23.97 13.69 15 57377 884 42563059
Shunt aneurysm 23.85 13.69 6 57386 25 42563918
Tinnitus 23.71 13.69 5 57387 28933 42535010
Nightmare 23.43 13.69 3 57389 25009 42538934
Hyperparathyroidism 23.41 13.69 17 57375 1282 42562661
Intervertebral disc space narrowing 22.98 13.69 16 57376 1129 42562814
Angiodysplasia 22.87 13.69 14 57378 793 42563150
Coma 22.85 13.69 23 57369 53531 42510412
Urinary tract infection 22.84 13.69 219 57173 99065 42464878
Wheezing 22.84 13.69 24 57368 54757 42509186
Transferrin saturation increased 22.81 13.69 8 57384 121 42563822
Pleuritic pain 22.73 13.69 37 57355 7040 42556903
Blood iron abnormal 22.57 13.69 8 57384 125 42563818
Peritoneal catheter insertion 22.45 13.69 4 57388 0 42563943
Anti-erythropoietin antibody 22.45 13.69 4 57388 0 42563943
Depressed level of consciousness 22.36 13.69 19 57373 47951 42515992
Insomnia 22.21 13.69 83 57309 118170 42445773
Blood potassium increased 22.19 13.69 65 57327 18471 42545472
Psoriasis 21.76 13.69 20 57372 48584 42515359
Heart rate decreased 21.73 13.69 11 57381 36521 42527422
Therapeutic product effect incomplete 21.62 13.69 39 57353 70900 42493043
Non-neutralising antibodies positive 21.59 13.69 7 57385 82 42563861
Parvovirus B19 test positive 21.58 13.69 8 57384 143 42563800
Depressed mood 21.44 13.69 3 57389 23381 42540562
Skin induration 21.43 13.69 19 57373 1908 42562035
Hypoaesthesia 21.14 13.69 40 57352 71423 42492520
Electrocardiogram QT prolonged 21.14 13.69 20 57372 47925 42516018
Myalgia 21.08 13.69 63 57329 96017 42467926
Malignant neoplasm progression 21.07 13.69 75 57317 108325 42455618
Aortic arteriosclerosis 21.01 13.69 30 57362 5090 42558853
Iron overload 20.89 13.69 17 57375 1518 42562425
Serum ferritin increased 20.86 13.69 36 57356 7183 42556760
Skin fibrosis 20.82 13.69 14 57378 933 42563010
Dysgeusia 20.78 13.69 10 57382 34179 42529764
Palpitations 20.35 13.69 23 57369 50774 42513169
Oxygen saturation decreased 20.22 13.69 35 57357 64652 42499291
Dialysis hypotension 20.13 13.69 6 57386 52 42563891
Stevens-Johnson syndrome 19.98 13.69 3 57389 22175 42541768
Productive cough 19.96 13.69 24 57368 51543 42512400
Cardio-respiratory arrest 19.95 13.69 30 57362 58606 42505337
Arteriovenous fistula site haemorrhage 19.89 13.69 7 57385 107 42563836
Feeling abnormal 19.83 13.69 40 57352 69746 42494197
Delirium 19.74 13.69 25 57367 52494 42511449
Renal cyst infection 19.66 13.69 7 57385 111 42563832
Aortic dilatation 19.65 13.69 17 57375 1652 42562291
Neurotoxicity 19.56 13.69 4 57388 23647 42540296
Total lung capacity decreased 19.40 13.69 24 57368 3546 42560397
Blood bilirubin increased 19.37 13.69 17 57375 42235 42521708
Hepatotoxicity 19.33 13.69 5 57387 25162 42538781
Anti-erythropoietin antibody negative 19.29 13.69 8 57384 195 42563748
Neutrophil count decreased 19.20 13.69 35 57357 63380 42500563
Frequent bowel movements 19.04 13.69 3 57389 21404 42542539
Abdominal pain upper 18.97 13.69 53 57339 82556 42481387
Pneumonia 18.82 13.69 720 56672 421429 42142514
Back pain 18.70 13.69 113 57279 141663 42422280
Drug level increased 18.66 13.69 6 57386 26194 42537749
Bone marrow failure 18.55 13.69 91 57301 33002 42530941
Cardiac valve disease 18.54 13.69 23 57369 3408 42560535
Peripheral swelling 18.53 13.69 61 57331 90209 42473734
Catheter placement 18.49 13.69 13 57379 932 42563011
COVID-19 18.30 13.69 87 57305 115861 42448082
Hot flush 18.03 13.69 4 57388 22347 42541596
Arthritis 18.02 13.69 18 57374 42047 42521896
Arteriovenous fistula occlusion 17.80 13.69 7 57385 148 42563795
Hypersensitivity 17.70 13.69 45 57347 72325 42491618
Gait disturbance 17.61 13.69 70 57322 97930 42466013
Seizure 17.57 13.69 93 57299 120468 42443475
Anaphylactic reaction 17.51 13.69 19 57373 42724 42521219
Therapy partial responder 17.38 13.69 3 57389 20018 42543925
Illness 17.25 13.69 6 57386 24924 42539019
Encephalomalacia 17.14 13.69 13 57379 1048 42562895
Inadequate osteointegration 16.92 13.69 4 57388 12 42563931
Stomatitis 16.88 13.69 26 57366 50303 42513640
Medical observation 16.84 13.69 3 57389 0 42563943
Oedema peripheral 16.82 13.69 267 57125 135809 42428134
Metastatic neoplasm 16.81 13.69 22 57370 3439 42560504
PCO2 decreased 16.67 13.69 16 57376 1778 42562165
Hypoxia 16.61 13.69 44 57348 69742 42494201
Heart rate increased 16.47 13.69 29 57363 53226 42510717
Toe amputation 16.42 13.69 20 57372 2909 42561034
Pain 16.25 13.69 232 57160 244616 42319327
Migraine 16.12 13.69 7 57385 25407 42538536
Myocarditis 16.09 13.69 3 57389 18935 42545008
Hepatic function abnormal 16.02 13.69 28 57364 51539 42512404
Urticaria 15.91 13.69 49 57343 73987 42489956
Hepatosplenomegaly 15.84 13.69 25 57367 4635 42559308
Blood product transfusion dependent 15.83 13.69 9 57383 444 42563499
Hyperlipidaemia 15.71 13.69 64 57328 21452 42542491
Blood parathyroid hormone increased 15.70 13.69 16 57376 1911 42562032
Flushing 15.68 13.69 16 57376 37012 42526931
Abnormal behaviour 15.68 13.69 8 57384 26443 42537500
Skin tightness 15.60 13.69 17 57375 2193 42561750
Diverticulum intestinal 15.44 13.69 26 57366 5087 42558856
Neoplasm progression 15.44 13.69 10 57382 28990 42534953
Decreased appetite 15.41 13.69 176 57216 192961 42370982
Sleep apnoea syndrome 15.30 13.69 5 57387 21603 42542340
Unresponsive to stimuli 15.18 13.69 12 57380 31391 42532552
Acute respiratory failure 15.13 13.69 18 57374 38840 42525103
Renal transplant failure 15.09 13.69 14 57378 1491 42562452
Blood glucose increased 14.99 13.69 50 57342 73649 42490294
Benign prostatic hyperplasia 14.88 13.69 62 57330 20990 42542953
Paraesthesia 14.83 13.69 50 57342 73409 42490534
Bradycardia 14.77 13.69 62 57330 85422 42478521
Accidental overdose 14.77 13.69 10 57382 28320 42535623
Arteriovenous graft thrombosis 14.76 13.69 3 57389 3 42563940
Oedema due to renal disease 14.76 13.69 3 57389 3 42563940
Dental restoration failure 14.70 13.69 4 57388 24 42563919
Balance disorder 14.69 13.69 26 57366 47619 42516324
Heart valve operation 14.61 13.69 5 57387 70 42563873
Toxic epidermal necrolysis 14.55 13.69 9 57383 26741 42537202
Blood pressure systolic increased 14.41 13.69 10 57382 27958 42535985
Chronic obstructive pulmonary disease 14.40 13.69 139 57253 62975 42500968
Diabetic gangrene 14.29 13.69 7 57385 254 42563689
Dialysis device insertion 14.29 13.69 4 57388 27 42563916
Reticulocyte count abnormal 14.29 13.69 4 57388 27 42563916
Erectile dysfunction 14.08 13.69 8 57384 24905 42539038
Skin hypertrophy 13.97 13.69 18 57374 2771 42561172
Adverse drug reaction 13.88 13.69 18 57374 37416 42526527
Neck pain 13.85 13.69 12 57380 30002 42533941
Eye pain 13.83 13.69 3 57389 17027 42546916
Diabetic complication 13.76 13.69 10 57382 755 42563188
Hepatitis 13.75 13.69 10 57382 27290 42536653
Benign neoplasm 13.71 13.69 7 57385 278 42563665

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Death 17455.24 13.16 8812 70062 690057 109820368
Hospitalisation 5632.40 13.16 2496 76378 139997 110370428
Investigation 2202.69 13.16 473 78401 1859 110508566
Aplasia pure red cell 1885.53 13.16 553 78321 9025 110501400
Arteriovenous fistula site complication 1237.81 13.16 255 78619 775 110509650
Haemodialysis 1061.69 13.16 419 78455 17300 110493125
Shunt stenosis 566.41 13.16 143 78731 1273 110509152
Dialysis 543.58 13.16 270 78604 19349 110491076
Appendicolith 451.51 13.16 215 78659 14040 110496385
Haemoglobin decreased 445.55 13.16 704 78170 248023 110262402
Transplant 433.01 13.16 113 78761 1161 110509264
Shunt occlusion 389.30 13.16 111 78763 1626 110508799
Haemoglobin abnormal 360.47 13.16 160 78714 8878 110501547
Appendicitis 334.38 13.16 224 78650 28240 110482185
Peritoneal dialysis 268.20 13.16 72 78802 832 110509593
Blood phosphorus increased 257.89 13.16 155 78719 16185 110494240
Hyperphosphataemia 257.53 13.16 155 78719 16226 110494199
Anaemia 255.08 13.16 913 77961 546173 109964252
End stage renal disease 240.31 13.16 164 78710 21309 110489116
Cardiac failure 226.56 13.16 447 78427 187179 110323246
Sepsis 223.90 13.16 624 78250 326722 110183703
Drug ineffective 223.08 13.16 471 78403 1520069 108990356
Terminal state 212.19 13.16 96 78778 5571 110504854
Cardiogenic shock 206.62 13.16 229 78645 57109 110453316
Ascites 204.93 13.16 290 78584 92518 110417907
Joint swelling 202.16 13.16 36 78838 442809 110067616
Anti-erythropoietin antibody positive 197.26 13.16 54 78820 675 110509750
Renal transplant 195.37 13.16 77 78797 3161 110507264
Ventricular fibrillation 190.03 13.16 188 78686 41125 110469300
Infusion related reaction 187.58 13.16 25 78849 381137 110129288
Arthralgia 186.73 13.16 169 78705 779463 109730962
Analgesic therapy 180.54 13.16 93 78781 7191 110503234
Blood uric acid increased 173.92 13.16 135 78739 21394 110489031
Multiple organ dysfunction syndrome 172.99 13.16 353 78521 151357 110359068
Drug therapy 171.85 13.16 90 78784 7201 110503224
Transformation to acute myeloid leukaemia 169.85 13.16 57 78817 1466 110508959
Transfusion 162.11 13.16 139 78735 25333 110485092
Headache 160.88 13.16 238 78636 882139 109628286
Rheumatoid arthritis 159.09 13.16 15 78859 299598 110210827
Contraindicated product administered 158.10 13.16 4 78870 248263 110262162
Myasthenia gravis 156.85 13.16 127 78747 21384 110489041
Hepatic enzyme increased 155.61 13.16 22 78852 320870 110189555
Alopecia 153.27 13.16 36 78838 364717 110145708
Renal impairment 152.87 13.16 383 78491 188062 110322363
Systemic lupus erythematosus 148.62 13.16 8 78866 254330 110256095
Sleep disorder therapy 147.53 13.16 82 78792 7389 110503036
Arthropathy 143.49 13.16 18 78856 287504 110222921
Renal disorder 142.23 13.16 176 78698 49303 110461122
Chronic kidney disease 140.54 13.16 219 78655 76072 110434353
Sinusitis 140.03 13.16 22 78852 296666 110213759
Iron deficiency 138.78 13.16 111 78763 18365 110492060
Arteriovenous fistula operation 136.91 13.16 35 78839 329 110510096
Azotaemia 134.62 13.16 86 78788 9999 110500426
Product use issue 134.48 13.16 29 78845 311666 110198759
Glossodynia 132.85 13.16 6 78868 221998 110288427
Abdominal discomfort 131.72 13.16 58 78816 393800 110116625
Gout 131.65 13.16 146 78728 36420 110474005
Activated partial thromboplastin time prolonged 130.15 13.16 116 78758 22252 110488173
Completed suicide 129.02 13.16 12 78862 242369 110268056
Hypersensitivity 128.17 13.16 64 78810 403934 110106491
Weight increased 127.93 13.16 70 78804 419574 110090851
Toxicity to various agents 126.24 13.16 95 78779 480460 110029965
Hypophosphataemia 122.07 13.16 134 78740 33048 110477377
Anticoagulant therapy 120.18 13.16 64 78810 5297 110505128
Treatment failure 119.17 13.16 26 78848 277208 110233217
Antacid therapy 118.82 13.16 64 78810 5420 110505005
Myelodysplastic syndrome 116.96 13.16 139 78735 37345 110473080
Nephrogenic systemic fibrosis 116.04 13.16 63 78811 5420 110505005
Pain 115.70 13.16 326 78548 954629 109555796
Bacterial infection 115.39 13.16 153 78721 45883 110464542
Diabetes mellitus 114.14 13.16 232 78642 99149 110411276
Pericarditis 111.08 13.16 13 78861 219101 110291324
Duodenal ulcer perforation 109.01 13.16 4 78870 177696 110332729
Stress 108.27 13.16 235 78639 105113 110405312
Renal failure 106.83 13.16 380 78494 226194 110284231
Folliculitis 102.07 13.16 4 78870 167649 110342776
Fibromyalgia 101.01 13.16 5 78869 170904 110339521
Peritonitis 100.23 13.16 120 78754 32487 110477938
Rash 98.08 13.16 282 78592 820682 109689743
Peripheral swelling 97.23 13.16 87 78787 403947 110106478
Irritable bowel syndrome 96.43 13.16 5 78869 164210 110346215
Type 2 diabetes mellitus 93.71 13.16 9 78865 177223 110333202
Thrombosis 93.52 13.16 226 78648 108436 110401989
Intentional product use issue 90.25 13.16 32 78842 247874 110262551
Hip fracture 89.91 13.16 118 78756 35033 110475392
Haemoglobin increased 88.68 13.16 64 78810 9083 110501342
Rehabilitation therapy 88.56 13.16 39 78835 2122 110508303
Reticulocyte count decreased 87.70 13.16 31 78843 935 110509490
Hypoaesthesia 86.54 13.16 59 78815 314164 110196261
Discomfort 84.76 13.16 24 78850 214683 110295742
Marasmus 84.09 13.16 35 78839 1656 110508769
Mineral supplementation 83.28 13.16 29 78845 836 110509589
Migraine 82.63 13.16 12 78862 171640 110338785
Nasopharyngitis 82.29 13.16 96 78778 394265 110116160
Angina pectoris 81.94 13.16 154 78720 62141 110448284
Thrombocytopenia 81.26 13.16 475 78399 348410 110162015
Wound 80.77 13.16 33 78841 234404 110276021
Abdominal distension 80.22 13.16 291 78583 174812 110335613
Blood test abnormal 79.54 13.16 100 78774 28454 110481971
Renal cyst haemorrhage 79.03 13.16 27 78847 734 110509691
Neuralgia 78.13 13.16 131 78743 48347 110462078
Depression 77.93 13.16 67 78807 317268 110193157
Muscle injury 77.58 13.16 6 78868 140801 110369624
Osteoarthritis 76.71 13.16 18 78856 182605 110327820
Hyperparathyroidism secondary 75.63 13.16 40 78834 3264 110507161
Memory impairment 74.14 13.16 24 78850 196920 110313505
Stomatitis 74.06 13.16 51 78823 270191 110240234
Arteriovenous fistula site infection 74.00 13.16 19 78855 182 110510243
Blood calcium increased 73.66 13.16 77 78797 17963 110492462
Liver injury 73.61 13.16 10 78864 150403 110360022
Blister 73.61 13.16 35 78839 227341 110283084
Anxiety 73.07 13.16 83 78791 344995 110165430
Refractory cytopenia with unilineage dysplasia 71.02 13.16 26 78848 869 110509556
Hypervolaemia 71.02 13.16 127 78747 49333 110461092
Impaired healing 70.56 13.16 26 78848 196691 110313734
Pneumonia 70.37 13.16 943 77931 875771 109634654
Peripheral arterial occlusive disease 70.22 13.16 56 78818 9224 110501201
Wheezing 68.84 13.16 49 78825 255181 110255244
Pleural effusion 68.83 13.16 280 78594 177429 110332996
Bursitis 67.63 13.16 7 78867 129911 110380514
Neoplasm malignant 67.51 13.16 106 78768 37037 110473388
Therapeutic product effect decreased 67.09 13.16 46 78828 244270 110266155
Body mass index abnormal 66.46 13.16 25 78849 903 110509522
Hyponatraemia 66.17 13.16 319 78555 217334 110293091
Urticaria 66.09 13.16 78 78796 318779 110191646
Arteriovenous fistula thrombosis 65 13.16 22 78852 581 110509844
Aortic stenosis 64.86 13.16 62 78812 12997 110497428
Obesity 64.86 13.16 4 78870 113347 110397078
Intermittent claudication 63.34 13.16 37 78837 3664 110506761
Hepatic cyst infection 62.96 13.16 17 78857 201 110510224
Hyperkalaemia 61.61 13.16 225 78649 135571 110374854
Unevaluable event 60.69 13.16 132 78742 59095 110451330
Blood creatinine increased 60.68 13.16 275 78599 182614 110327811
Drug interaction 60.22 13.16 171 78703 500012 110010413
Lip dry 58.90 13.16 3 78871 100080 110410345
Arthritis 58.68 13.16 23 78851 167563 110342862
Palliative care 58.31 13.16 27 78847 1653 110508772
Suicide attempt 58.12 13.16 4 78870 103390 110407035
Renal artery stenosis 57.89 13.16 35 78839 3691 110506734
Iron overload 57.78 13.16 29 78845 2122 110508303
Central nervous system lupus 57.33 13.16 25 78849 1328 110509097
Congenital hiatus hernia 56.62 13.16 42 78832 6217 110504208
Inflammation 56.30 13.16 34 78840 193204 110317221
Night sweats 54.71 13.16 14 78860 133969 110376456
Pain in extremity 54.69 13.16 172 78702 486946 110023479
Constipation 54.02 13.16 438 78436 357348 110153077
Leg amputation 53.90 13.16 35 78839 4183 110506242
Product use in unapproved indication 53.80 13.16 153 78721 447224 110063201
Serositis 53.78 13.16 25 78849 1544 110508881
Dizziness 53.65 13.16 286 78588 697907 109812518
Cardiac failure congestive 52.31 13.16 230 78644 150770 110359655
Insomnia 52.21 13.16 112 78762 360478 110149947
Anti-erythropoietin antibody negative 52.18 13.16 16 78858 305 110510120
Suicidal ideation 51.75 13.16 4 78870 93933 110416492
Incorrect route of product administration 51.67 13.16 130 78744 63931 110446494
Delayed graft function 51.18 13.16 34 78840 4223 110506202
Zoonotic bacterial infection 50.84 13.16 12 78862 78 110510347
Renal cyst infection 50.09 13.16 15 78859 263 110510162
Parvovirus B19 infection 49.83 13.16 29 78845 2852 110507573
Fatigue 49.69 13.16 592 78282 1215366 109295059
Injury 49.16 13.16 33 78841 177232 110333193
Asthma 48.95 13.16 64 78810 250227 110260198
Loss of personal independence in daily activities 48.68 13.16 23 78851 149997 110360428
Premature delivery 48.33 13.16 82 78792 30550 110479875
Fracture 48.22 13.16 73 78801 24715 110485710
Drug-induced liver injury 48.16 13.16 13 78861 120054 110390371
Benign prostatic hyperplasia 47.85 13.16 62 78812 18172 110492253
Visual impairment 47.81 13.16 18 78856 134410 110376015
Prescribed overdose 47.49 13.16 4 78870 87577 110422848
Bacteroides infection 46.86 13.16 28 78846 2891 110507534
Vena cava injury 46.61 13.16 15 78859 337 110510088
Gastrointestinal disorder 46.16 13.16 63 78811 241889 110268536
Psoriasis 46.14 13.16 21 78853 139972 110370453
Therapeutic product effect incomplete 46.09 13.16 55 78819 223750 110286675
Paraesthesia 46.03 13.16 79 78795 276442 110233983
Muscle spasms 45.82 13.16 80 78794 278077 110232348
Shunt infection 45.46 13.16 14 78860 271 110510154
Product storage error 45.15 13.16 66 78808 21662 110488763
Dyspepsia 44.85 13.16 42 78832 190923 110319502
Therapeutic response decreased 44.70 13.16 161 78713 96338 110414087
SARS-CoV-2 antibody test positive 44.18 13.16 15 78859 400 110510025
Vascular anastomotic haemorrhage 44.17 13.16 14 78860 299 110510126
Plasma cell myeloma 43.91 13.16 121 78753 62815 110447610
Product quality issue 43.42 13.16 3 78871 77296 110433129
Hyperparathyroidism 42.38 13.16 29 78845 3781 110506644
Abdominal wall haemorrhage 42.27 13.16 17 78857 736 110509689
Complications of transplanted kidney 42.11 13.16 38 78836 7404 110503021
Musculoskeletal stiffness 42.11 13.16 85 78789 279737 110230688
Blood parathyroid hormone increased 41.82 13.16 30 78844 4218 110506207
Lupus nephritis 41.64 13.16 31 78843 4614 110505811
Illness 41.32 13.16 5 78869 82166 110428259
Reticulocyte count abnormal 41.30 13.16 11 78863 123 110510302
Erythropoiesis abnormal 41.25 13.16 16 78858 629 110509796
Blood potassium increased 41.01 13.16 80 78794 33169 110477256
Colitis ulcerative 40.70 13.16 4 78870 77359 110433066
Living in residential institution 40.64 13.16 18 78856 993 110509432
Injection site erythema 40.10 13.16 9 78865 94167 110416258
Bronchopulmonary aspergillosis allergic 39.96 13.16 39 78835 8387 110502038
Drug intolerance 39.90 13.16 152 78722 406360 110104065
Troponin increased 39.65 13.16 74 78800 29692 110480733
Abdominal pain upper 39.35 13.16 123 78751 348988 110161437
Agranulocytosis 38.48 13.16 114 78760 61646 110448779
Gait inability 38.33 13.16 25 78849 136351 110374074
Pruritus 37.87 13.16 251 78623 581309 109929116
Drug hypersensitivity 37.68 13.16 181 78693 453909 110056516
Hyperhidrosis 37.54 13.16 47 78827 187251 110323174
Mobility decreased 36.68 13.16 71 78803 237351 110273074
Skin induration 36.45 13.16 28 78846 4367 110506058
Bone marrow failure 36.26 13.16 107 78767 57741 110452684
Hyperlipidaemia 35.71 13.16 79 78795 35769 110474656
Chronic obstructive pulmonary disease 35.34 13.16 163 78711 108995 110401430
Reticulocytopenia 35.31 13.16 12 78862 321 110510104
Mycobacterium marinum infection 35.26 13.16 15 78859 750 110509675
Sciatica 35.23 13.16 11 78863 92388 110418037
Cardiac valve disease 34.80 13.16 32 78842 6389 110504036
Perineal cyst 34.79 13.16 11 78863 233 110510192
Pulmonary embolism 34.78 13.16 267 78607 214207 110296218
Rectal prolapse 34.56 13.16 22 78852 2541 110507884
Red blood cell sedimentation rate increased 34.32 13.16 7 78867 78295 110432130
Gait disturbance 34.26 13.16 94 78780 278114 110232311
Serum ferritin increased 33.81 13.16 42 78832 11805 110498620
Ear infection 33.65 13.16 3 78871 62729 110447696
Cardiac output decreased 33.61 13.16 20 78854 2049 110508376
Arteriovenous fistula site haemorrhage 33.60 13.16 12 78862 373 110510052
Skin hypertrophy 33.04 13.16 28 78846 5019 110505406
Drug ineffective for unapproved indication 33.01 13.16 16 78858 102822 110407603
Arteriovenous fistula occlusion 32.93 13.16 13 78861 536 110509889
Procalcitonin abnormal 32.90 13.16 12 78862 397 110510028
Ill-defined disorder 32.87 13.16 38 78836 156815 110353610
Feeling hot 32.73 13.16 12 78862 91094 110419331
Prescribed underdose 32.68 13.16 4 78870 65170 110445255
Musculoskeletal pain 32.60 13.16 50 78824 182973 110327452
Nasal congestion 31.99 13.16 15 78859 98267 110412158
Diabetic complication 31.94 13.16 17 78857 1405 110509020
Weight decreased 31.48 13.16 200 78674 467857 110042568
Deep vein thrombosis postoperative 31.36 13.16 3 78871 59288 110451137
Transferrin saturation increased 31.31 13.16 10 78864 219 110510206
Serotonin syndrome 31.27 13.16 3 78871 59150 110451275
Renal transplant failure 31.24 13.16 21 78853 2659 110507766
Haematocrit decreased 31.21 13.16 111 78763 66006 110444419
Road traffic accident 31.13 13.16 19 78855 107379 110403046
Carotid arteriosclerosis 31.04 13.16 22 78852 3035 110507390
Sedation 31.03 13.16 6 78868 69677 110440748
Live birth 30.90 13.16 6 78868 69478 110440947
General physical health deterioration 30.57 13.16 449 78425 424846 110085579
Intraductal papillary mucinous neoplasm 30.42 13.16 14 78860 845 110509580
Total lung capacity decreased 30.19 13.16 31 78843 7083 110503342
Frequent bowel movements 30.04 13.16 7 78867 71383 110439042
Hemianopia 29.95 13.16 21 78853 2847 110507578
Depressed mood 29.85 13.16 4 78870 60805 110449620
Mean cell volume increased 29.53 13.16 33 78841 8297 110502128
Febrile bone marrow aplasia 29.22 13.16 48 78826 17417 110493008
Hepatitis 28.92 13.16 14 78860 90040 110420385
Cerebral infarction 28.86 13.16 92 78782 51746 110458679
Adverse drug reaction 28.79 13.16 20 78854 105539 110404886
Haemorrhage 28.61 13.16 151 78723 106541 110403884
Hypocalcaemia 28.54 13.16 107 78767 65259 110445166
Vascular compression 28.51 13.16 13 78861 768 110509657
Taste disorder 28.34 13.16 6 78868 65381 110445044
Tachycardia 28.34 13.16 76 78798 226569 110283856
Injection site swelling 28.20 13.16 5 78869 61785 110448640
Oropharyngeal pain 28.10 13.16 33 78841 135243 110375182
Knee arthroplasty 28.07 13.16 6 78868 64942 110445483
Condition aggravated 27.94 13.16 363 78511 734473 109775952
Blood 25-hydroxycholecalciferol decreased 27.60 13.16 11 78863 465 110509960
Haemolysis 27.55 13.16 44 78830 15595 110494830
Intervertebral disc space narrowing 27.39 13.16 17 78857 1879 110508546
Gastrointestinal haemorrhage 27.35 13.16 207 78667 165311 110345114
Transient ischaemic attack 27.33 13.16 104 78770 63878 110446547
Ulcer 27.26 13.16 80 78794 43036 110467389
Joint range of motion decreased 27.21 13.16 28 78846 121804 110388621
Pulmonary fibrosis 26.96 13.16 20 78854 102022 110408403
Oedema peripheral 26.85 13.16 355 78519 328305 110182120
Injection site pain 26.79 13.16 54 78820 177868 110332557
Skin fibrosis 26.64 13.16 15 78859 1385 110509040
Shunt malfunction 26.61 13.16 10 78864 360 110510065
Peritonitis bacterial 26.38 13.16 35 78839 10498 110499927
Product dose omission issue 26.25 13.16 129 78745 321653 110188772
Upper respiratory tract inflammation 26.09 13.16 23 78851 4348 110506077
Rhinorrhoea 26.01 13.16 21 78853 102645 110407780
Delirium 25.90 13.16 35 78839 134990 110375435
Shunt aneurysm 25.69 13.16 6 78868 37 110510388
Muscular weakness 25.61 13.16 91 78783 248377 110262048
Maternal exposure during pregnancy 25.18 13.16 95 78779 254788 110255637
Home care 24.99 13.16 4 78870 0 110510425
Skin tightness 24.80 13.16 25 78849 5588 110504837
Aortic dilatation 24.76 13.16 17 78857 2229 110508196
Anaphylactic reaction 24.70 13.16 27 78847 114273 110396152
Maternal condition affecting foetus 24.68 13.16 8 78866 184 110510241
Flushing 24.62 13.16 23 78851 104713 110405712
Cough 24.45 13.16 211 78663 461430 110048995
Dry eye 24.43 13.16 5 78869 55788 110454637
Anti-erythropoietin antibody 24.07 13.16 5 78869 16 110510409
Medication error 23.77 13.16 24 78850 105342 110405083
PCO2 decreased 23.76 13.16 19 78855 3142 110507283
Gastroenteritis 23.58 13.16 71 78803 38729 110471696
Back injury 23.55 13.16 3 78871 47396 110463029
Neck pain 23.53 13.16 32 78842 123098 110387327
Exposure during pregnancy 23.39 13.16 53 78821 167371 110343054
Hepatotoxicity 23.37 13.16 8 78866 63392 110447033
Amegakaryocytic thrombocytopenia 23.20 13.16 5 78869 20 110510405
Hyperuricaemia 23.05 13.16 39 78835 14492 110495933
Haemodialysis complication 23.05 13.16 9 78865 360 110510065
Throat irritation 23.04 13.16 5 78869 53547 110456878
Agitation 23.03 13.16 28 78846 113023 110397402
Wound infection 22.89 13.16 21 78853 96444 110413981
Bone erosion 22.88 13.16 3 78871 46368 110464057
Angioedema 22.72 13.16 22 78852 98478 110411947
Alanine aminotransferase increased 22.69 13.16 62 78812 183711 110326714
Cardiac arrest 22.56 13.16 227 78647 196526 110313899
Overdose 22.54 13.16 88 78786 233706 110276719
Cardiovascular disorder 22.49 13.16 50 78824 22710 110487715
Toe amputation 22.31 13.16 21 78853 4317 110506108
Hepatosplenomegaly 22.14 13.16 26 78848 6893 110503532
Metastatic neoplasm 22.09 13.16 24 78850 5849 110504576
Device related infection 21.88 13.16 70 78804 39449 110470976
Cardiac disorder 21.87 13.16 110 78764 76170 110434255
Abdominal pain 21.84 13.16 499 78375 512490 109997935
Vision blurred 21.33 13.16 37 78837 128985 110381440
Nausea 21.23 13.16 696 78178 1234994 109275431
Aortic arteriosclerosis 20.97 13.16 32 78842 10906 110499519
Serum ferritin abnormal 20.97 13.16 9 78865 460 110509965
Hallucination 20.79 13.16 25 78849 101407 110409018
Large intestine polyp 20.66 13.16 38 78836 15079 110495346
Peritoneal dialysis complication 20.63 13.16 16 78858 2530 110507895
Aspiration 20.60 13.16 58 78816 30475 110479950
Encephalomalacia 20.52 13.16 13 78861 1489 110508936
Angiodysplasia 20.52 13.16 13 78861 1489 110508936
Laryngitis 20.32 13.16 3 78871 42408 110468017
Blood erythropoietin increased 20.28 13.16 5 78869 40 110510385
Lymphocele 20.24 13.16 14 78860 1857 110508568
Haematochezia 20.15 13.16 32 78842 115492 110394933
Kidney transplant rejection 20.13 13.16 33 78841 11954 110498471
Pleuritic pain 20.11 13.16 39 78835 16101 110494324
Injection site pruritus 19.72 13.16 6 78868 51252 110459173
PO2 decreased 19.66 13.16 17 78857 3131 110507294
Balance disorder 19.66 13.16 33 78841 116527 110393898
Heart rate decreased 19.66 13.16 18 78856 82738 110427687
Myelosuppression 19.61 13.16 23 78851 94317 110416108
Pregnancy 19.61 13.16 6 78868 51061 110459364
Lower limb fracture 19.61 13.16 15 78859 75333 110435092
Psychotic disorder 19.53 13.16 6 78868 50931 110459494
Irritability 19.50 13.16 5 78869 47804 110462621
Inadequate osteointegration 19.45 13.16 4 78870 12 110510413
Feeling abnormal 19.42 13.16 65 78809 180646 110329779
Ischaemic stroke 19.24 13.16 69 78805 41194 110469231
Neutralising antibodies positive 19.19 13.16 8 78866 380 110510045
Calciphylaxis 19.15 13.16 19 78855 4168 110506257
Diabetic gangrene 19.12 13.16 7 78867 234 110510191
Sleep apnoea syndrome 19.06 13.16 3 78871 40444 110469981
Chest discomfort 19.05 13.16 62 78812 173786 110336639
Lactic acidosis 18.89 13.16 23 78851 92788 110417637
Respiratory disorder 18.85 13.16 14 78860 71368 110439057
Reticulocyte percentage decreased 18.74 13.16 3 78871 0 110510425
Volume blood increased 18.74 13.16 3 78871 0 110510425
Cytomegalovirus pancreatitis 18.74 13.16 3 78871 0 110510425
Gangrene 18.57 13.16 38 78836 16303 110494122
Natural killer cell count 18.56 13.16 4 78870 16 110510409
Cognitive disorder 18.55 13.16 21 78853 87490 110422935
Myocardial infarction 18.48 13.16 214 78660 191869 110318556
Squamous cell carcinoma of skin 18.38 13.16 39 78835 17164 110493261
Confusional state 18.35 13.16 230 78644 468450 110041975
Dialysis device insertion 18.30 13.16 5 78869 62 110510363
Uterine atony 18.30 13.16 7 78867 265 110510160
Injection site reaction 18.21 13.16 22 78852 89048 110421377
Sudden death 18.12 13.16 48 78826 24347 110486078
Gastric cancer 18.07 13.16 30 78844 10978 110499447
Disturbance in attention 17.92 13.16 11 78863 61984 110448441
Influenza like illness 17.90 13.16 22 78852 88390 110422035
Lung neoplasm malignant 17.88 13.16 59 78815 33783 110476642
Nephrogenic anaemia 17.73 13.16 19 78855 4558 110505867
Dehydration 17.73 13.16 289 78585 279222 110231203
Urinary tract infection 17.69 13.16 329 78545 325953 110184472
Amnesia 17.63 13.16 30 78844 105378 110405047
Ear pain 17.51 13.16 8 78866 53218 110457207
Osteoporosis 17.32 13.16 22 78852 87130 110423295
Blood product transfusion dependent 17.32 13.16 8 78866 487 110509938
Palpitations 17.29 13.16 57 78817 159155 110351270
Thrombosis in device 17.02 13.16 20 78854 5307 110505118
Lung opacity 16.82 13.16 30 78844 11622 110498803
Parakeratosis 16.78 13.16 8 78866 523 110509902
Coma 16.72 13.16 37 78837 117832 110392593
Diverticulum intestinal 16.70 13.16 30 78844 11689 110498736
Joint contracture 16.68 13.16 14 78860 2477 110507948
Transfusion reaction 16.67 13.16 13 78861 2072 110508353
Contusion 16.56 13.16 98 78776 233263 110277162
Cardiac failure acute 16.50 13.16 46 78828 24032 110486393
Back pain 16.48 13.16 177 78697 370819 110139606
Injection site bruising 16.41 13.16 8 78866 51255 110459170
Dysphonia 16.34 13.16 18 78856 75911 110434514
Subdural haematoma 16.18 13.16 60 78814 36394 110474031
Hot flush 16.12 13.16 14 78860 66022 110444403
Fungal endocarditis 16.03 13.16 9 78865 827 110509598
Nightmare 15.98 13.16 4 78870 38859 110471566
Heart rate increased 15.96 13.16 51 78823 143783 110366642
Dry skin 15.93 13.16 33 78841 107620 110402805
Acute leukaemia 15.82 13.16 12 78862 1837 110508588
Aortic valve stenosis 15.75 13.16 21 78853 6329 110504096
Actinic keratosis 15.59 13.16 22 78852 6991 110503434
Essential thrombocythaemia 15.55 13.16 7 78867 401 110510024
Spinal compression fracture 15.54 13.16 38 78836 18354 110492071
Myalgia 15.46 13.16 94 78780 222287 110288138
Neoplasm progression 15.40 13.16 14 78860 64581 110445844
Platelet count decreased 15.26 13.16 240 78634 230203 110280222
Eye infection bacterial 15.20 13.16 7 78867 423 110510002
Oxygen saturation decreased 15.18 13.16 59 78815 156923 110353502
Pyelonephritis 15.15 13.16 46 78828 25204 110485221
Acute myocardial infarction 15.11 13.16 107 78767 83670 110426755
Pelvic fracture 15.02 13.16 32 78842 14122 110496303
Colon cancer 15.00 13.16 35 78839 16408 110494017
Haematuria 14.96 13.16 106 78768 82899 110427526
Coombs test positive 14.91 13.16 6 78868 260 110510165
Deep vein thrombosis 14.89 13.16 159 78715 139728 110370697
Renal lymphocele 14.88 13.16 5 78869 129 110510296
Aneurysm 14.72 13.16 17 78857 4429 110505996
Eye irritation 14.64 13.16 3 78871 33449 110476976
Dysgeusia 14.61 13.16 17 78857 69968 110440457
Sopor 14.57 13.16 4 78870 36542 110473883
Movement disorder 14.49 13.16 4 78870 36400 110474025
Atrioventricular block 14.40 13.16 35 78839 16842 110493583
Presyncope 14.37 13.16 71 78803 48816 110461609
Micturition urgency 14.33 13.16 38 78836 19282 110491143
Eye pain 14.33 13.16 9 78865 50090 110460335
Abnormal behaviour 14.26 13.16 5 78869 39034 110471391
Chest pain 14.24 13.16 186 78688 376189 110134236
Gallbladder disorder 14.24 13.16 40 78834 20989 110489436
Inappropriate schedule of product administration 14.19 13.16 86 78788 203551 110306874
Immunodeficiency 14.14 13.16 5 78869 38833 110471592
Leukopenia 13.97 13.16 165 78709 148626 110361799
Shunt thrombosis 13.92 13.16 5 78869 158 110510267
CALR gene mutation 13.92 13.16 3 78871 12 110510413
Nephrolithiasis 13.91 13.16 16 78858 66196 110444229
Fall 13.90 13.16 544 78330 602938 109907487
Productive cough 13.78 13.16 39 78835 114266 110396159
Sneezing 13.73 13.16 3 78871 31981 110478444
Cytokine release syndrome 13.71 13.16 18 78856 70288 110440137
Dialysis related complication 13.67 13.16 6 78868 324 110510101
Retinal artery occlusion 13.65 13.16 16 78858 4233 110506192
Dermatitis exfoliative 13.63 13.16 27 78847 11320 110499105
Red blood cell count decreased 13.57 13.16 87 78787 65836 110444589
Hepatic cirrhosis 13.51 13.16 17 78857 67609 110442816
Polycythaemia 13.41 13.16 14 78860 3261 110507164
Pancytopenia 13.38 13.16 217 78657 209396 110301029
Extramedullary haemopoiesis 13.38 13.16 6 78868 341 110510084
Bicytopenia 13.36 13.16 20 78854 6704 110503721
Occupational exposure to product 13.34 13.16 8 78866 831 110509594
Atrial fibrillation 13.30 13.16 234 78640 229408 110281017
Electrocardiogram QT prolonged 13.27 13.16 37 78837 108923 110401502
Urine odour abnormal 13.25 13.16 21 78853 7394 110503031
Ceruloplasmin decreased 13.21 13.16 3 78871 16 110510409

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC B03XA02 BLOOD AND BLOOD FORMING ORGANS
ANTIANEMIC PREPARATIONS
OTHER ANTIANEMIC PREPARATIONS
Other antianemic preparations
FDA CS M0007726 Erythropoietin
FDA PE N0000009319 Increased Erythroid Cell Production
MeSH PA D006397 Hematinics
MeSH PA D006401 Hematologic Agents
FDA EPC N0000175665 Erythropoiesis-stimulating Agent
CHEBI has role CHEBI:35554 cardiovascular drug
CHEBI has role CHEBI:35610 antineoplastic agent
CHEBI has role CHEBI:63726 neuroprotective agent
CHEBI has role CHEBI:75835 anti-anaemic agent
CHEBI has role CHEBI:231911 renoprotective agent

Related Drugs by ATC class:

B03XA Other antianemic preparations 8 drugs
daprodustatepoetin alfaluspaterceptmethoxy polyethylene glycol-epoetin betamolidustatpeginesatideroxadustatvadadustat

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Anemia of renal disease indication 234348004
Anemia due to and following chemotherapy indication 767657005
Hypertensive disorder contraindication 38341003 DOID:10763




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Erythropoietin receptor Membrane receptor AGONIST DRUG LABEL DRUG LABEL

External reference:

IDSource
15UQ94PT4P UNII
4021274 VANDF
C0937950 UMLSCUI
CHEBI:749503 CHEBI
CHEMBL1201566 ChEMBL_ID
DB00012 DRUGBANK_ID
D000068256 MESH_DESCRIPTOR_UI
D03651 KEGG_DRUG
8073 INN_ID
283838 RXNORM
385608005 SNOMEDCT_US
385610007 SNOMEDCT_US
16174 MMSL
42263 MMSL
d04771 MMSL
009195 NDDF

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
ARANESP HUMAN PRESCRIPTION DRUG LABEL 1 55513-002 SOLUTION 25 ug INTRAVENOUS BLA 31 sections
ARANESP HUMAN PRESCRIPTION DRUG LABEL 1 55513-003 SOLUTION 40 ug INTRAVENOUS BLA 31 sections
ARANESP HUMAN PRESCRIPTION DRUG LABEL 1 55513-004 SOLUTION 60 ug INTRAVENOUS BLA 31 sections
ARANESP HUMAN PRESCRIPTION DRUG LABEL 1 55513-005 SOLUTION 100 ug INTRAVENOUS BLA 31 sections
ARANESP HUMAN PRESCRIPTION DRUG LABEL 1 55513-006 SOLUTION 200 ug INTRAVENOUS BLA 31 sections
ARANESP HUMAN PRESCRIPTION DRUG LABEL 1 55513-021 INJECTION, SOLUTION 40 ug INTRAVENOUS BLA 31 sections
ARANESP HUMAN PRESCRIPTION DRUG LABEL 1 55513-023 INJECTION, SOLUTION 60 ug INTRAVENOUS BLA 31 sections
ARANESP HUMAN PRESCRIPTION DRUG LABEL 1 55513-025 INJECTION, SOLUTION 100 ug INTRAVENOUS BLA 31 sections
ARANESP HUMAN PRESCRIPTION DRUG LABEL 1 55513-027 INJECTION, SOLUTION 150 ug INTRAVENOUS BLA 31 sections
ARANESP HUMAN PRESCRIPTION DRUG LABEL 1 55513-028 INJECTION, SOLUTION 200 ug INTRAVENOUS BLA 31 sections
ARANESP HUMAN PRESCRIPTION DRUG LABEL 1 55513-032 INJECTION, SOLUTION 500 ug INTRAVENOUS BLA 31 sections
ARANESP HUMAN PRESCRIPTION DRUG LABEL 1 55513-057 INJECTION, SOLUTION 25 ug INTRAVENOUS BLA 31 sections
ARANESP HUMAN PRESCRIPTION DRUG LABEL 1 55513-098 INJECTION, SOLUTION 10 ug INTRAVENOUS BLA 31 sections
ARANESP HUMAN PRESCRIPTION DRUG LABEL 1 55513-111 INJECTION, SOLUTION 300 ug INTRAVENOUS BLA 31 sections