chloramphenicol palmitate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 5150 | 530-43-8 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
An antibiotic first isolated from cultures of Streptomyces venequelae in 1947 but now produced synthetically. It has relatively simple structure and was the first broad-spectrum antibiotic to be discovered. It acts by interfering with bacterial protein synthesis and is mainly bacteriostatic. (From Martindale, The Extra Pharmacopoeia, 29th ed, p106)
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
None
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| BA (Bioavailability) | 80 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| None | FDA |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| FDA EXT | N0000175479 | Amphenicols |
| FDA EPC | N0000175480 | Amphenicol-class Antibacterial |
| MeSH PA | D000900 | Anti-Bacterial Agents |
| MeSH PA | D000890 | Anti-Infective Agents |
| MeSH PA | D004791 | Enzyme Inhibitors |
| MeSH PA | D011500 | Protein Synthesis Inhibitors |
| CHEBI has role | CHEBI:33281 | antibiotics |
| CHEBI has role | CHEBI:36047 | antibacterial drugs |
| CHEBI has role | CHEBI:48001 | protein synthesis inhibitors |
| CHEBI has role | CHEBI:76971 | Escherichia coli metabolites |
| CHEBI has role | CHEBI:131604 | Mycoplasma genitalium metabolites |
| CHEBI has role | CHEBI:176497 | geroprotectors |
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
| Species | Use | Relation |
|---|---|---|
| Cats | Bacterial conjunctivitis | Indication |
| Dogs | Respiratory tract infections | Indication |
| Dogs | Urinary tract infections | Indication |
| Dogs | Bacterand enteritis | Indication |
| Dogs | Tonsillitis | Indication |
🐶 Veterinary products
| Product | Applicant | Ingredients |
|---|---|---|
| Chloromycetin Palmitate Oral Suspension | Zoetis Inc. | 1 |
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 10.37 | acidic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
None
External reference:
| ID | Source |
|---|---|
| 43VU4207NW | UNII |
| 4018199 | VANDF |
| 4018201 | VANDF |
| C0055337 | UMLSCUI |
| CHEBI:3605 | CHEBI |
| CHEBI:17698 | CHEBI |
| CLM | PDB_CHEM_ID |
| CHEMBL1506 | ChEMBL_ID |
| D01072 | KEGG_DRUG |
| 443382 | PUBCHEM_CID |
| DB14658 | DRUGBANK_ID |
| 20767 | RXNORM |
| 20707 | MMSL |
| 3887 | MMSL |
| 4406 | MMSL |
| 73105 | MMSL |
| d00025 | MMSL |
| 002767 | NDDF |
| 002768 | NDDF |
| 29327006 | SNOMEDCT_US |
| 372777009 | SNOMEDCT_US |
| 57191001 | SNOMEDCT_US |
| C0008168 | UMLSCUI |
| DB00446 | DRUGBANK_ID |
| 977 | INN_ID |
| D002701 | MESH_DESCRIPTOR_UI |
| C030578 | MESH_SUPPLEMENTAL_RECORD_UI |
| 5959 | PUBCHEM_CID |
Pharmaceutical products:
None