carperitide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
natriuretic peptides	515	89213-87-6

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

carperitide
human atrial natriuretic peptide
atriopeptin
carperitide (recombinant)

Molecular weight: 3080.48
Formula: C127H203N45O39S3
CLOGP:
LIPINSKI: 3
HAC: 84
HDO: 53
TPSA: 1403.38
ALOGS: -4.44
ROTB: 70

Drug dosage:

None

ADMET properties:

Property	Value	Reference
Vd (Volume of distribution)	0.20 L/kg	Lombardo F, Berellini G, Obach RS
CL (Clearance)	25.40 mL/min/kg	Lombardo F, Berellini G, Obach RS
t_half (Half-life)	0.22 hours	Lombardo F, Berellini G, Obach RS

Approvals:

None

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Cardiac failure	79.06	59.02	26	306	82067	56209668

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Cardiac failure	48.28	33.96	25	507	85928	31610884
Cardiac failure chronic	34.23	33.96	10	522	7293	31689519

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Cardiac failure	103.74	38.53	47	956	143494	70783947
Renal impairment	58.65	38.53	32	971	143905	70783536
Hypernatraemia	42.87	38.53	13	990	12748	70914693
Cardiac failure chronic	41.19	38.53	12	991	10257	70917184
Hepatic function abnormal	38.82	38.53	19	984	67977	70859464

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

None

Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	3.23	acidic
pKa2	3.93	acidic
pKa3	9.86	acidic
pKa4	12.0	acidic
pKa5	12.06	acidic
pKa6	12.45	acidic
pKa7	12.66	acidic
pKa8	12.66	acidic
pKa9	12.81	acidic
pKa10	13.02	acidic
pKa11	13.03	acidic
pKa12	13.04	acidic
pKa13	13.28	acidic
pKa14	13.37	acidic
pKa15	13.59	acidic
pKa16	13.62	acidic
pKa17	13.62	acidic
pKa18	13.8	acidic
pKa19	13.82	acidic
pKa20	13.89	acidic
pKa21	13.96	acidic
pKa22	11.2	Basic
pKa23	11.0	Basic
pKa24	10.83	Basic
pKa25	10.67	Basic
pKa26	10.5	Basic
pKa27	7.66	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Atrial natriuretic peptide receptor 1	Enzyme	P16066	ANPRA_HUMAN		EC50	10		CHEMBL
Atrial natriuretic peptide receptor 1	Enzyme		ANPRA_RAT		EC50	9		CHEMBL

External reference:

ID	Source
D03328	KEGG_DRUG
C0102586	UMLSCUI
CHEBI:135914	CHEBI
CHEMBL2104386	ChEMBL_ID
C472955	MESH_SUPPLEMENTAL_RECORD_UI
6699	INN_ID
GZ8FA500J0	UNII
16129708	PUBCHEM_CID
DB15591	DRUGBANK_ID
30326004	SNOMEDCT_US

Pharmaceutical products:

None