carperitide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
natriuretic peptides 515 89213-87-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • carperitide
  • human atrial natriuretic peptide
  • atriopeptin
  • carperitide (recombinant)
  • Molecular weight: 3080.48
  • Formula: C127H203N45O39S3
  • CLOGP:
  • LIPINSKI: 3
  • HAC: 84
  • HDO: 53
  • TPSA: 1403.38
  • ALOGS: -4.44
  • ROTB: 70

Drug dosage:

None

ADMET properties:

PropertyValueReference
Vd (Volume of distribution) 0.20 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 25.40 mL/min/kg Lombardo F, Berellini G, Obach RS
t_half (Half-life) 0.22 hours Lombardo F, Berellini G, Obach RS

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Cardiac failure 67.57 37.76 34 863 132339 64365496
Renal impairment 44.54 37.76 26 871 134991 64362844
Hypernatraemia 43.68 37.76 13 884 12176 64485659

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

None

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 3.23 acidic
pKa2 3.93 acidic
pKa3 9.86 acidic
pKa4 12.0 acidic
pKa5 12.06 acidic
pKa6 12.45 acidic
pKa7 12.66 acidic
pKa8 12.66 acidic
pKa9 12.81 acidic
pKa10 13.02 acidic
pKa11 13.03 acidic
pKa12 13.04 acidic
pKa13 13.28 acidic
pKa14 13.37 acidic
pKa15 13.59 acidic
pKa16 13.62 acidic
pKa17 13.62 acidic
pKa18 13.8 acidic
pKa19 13.82 acidic
pKa20 13.89 acidic
pKa21 13.96 acidic
pKa22 11.2 Basic
pKa23 11.0 Basic
pKa24 10.83 Basic
pKa25 10.67 Basic
pKa26 10.5 Basic
pKa27 7.66 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Atrial natriuretic peptide receptor 1 Enzyme EC50 10 CHEMBL
Atrial natriuretic peptide receptor 1 Enzyme EC50 9 CHEMBL

External reference:

IDSource
D03328 KEGG_DRUG
C0102586 UMLSCUI
CHEBI:135914 CHEBI
CHEMBL2104386 ChEMBL_ID
C472955 MESH_SUPPLEMENTAL_RECORD_UI
6699 INN_ID
GZ8FA500J0 UNII
16129708 PUBCHEM_CID
DB15591 DRUGBANK_ID
30326004 SNOMEDCT_US

Pharmaceutical products:

None