poractant alfa 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
5148 129069-19-8

Description:

MoleculeDescription

Synonyms:

  • poractant alfa
  • curosurf
Endogenous pulmonary surfactant (isolated from porcine lungs) reduces surface tension at the air-liquid interface of the alveoli during ventilation and stabilizes the alveoli against collapse at resting transpulmonary pressures. A deficiency of pulmonary surfactant in preterm infants results in Respiratory Distress Syndrome (RDS) characterized by poor lung expansion, inadequate gas exchange, and a gradual collapse of the lungs (atelectasis).
  • Molecular weight:
  • Formula:
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA:
  • ALOGS:
  • ROTB: None

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Nov. 18, 1999 FDA CHIESI USA INC

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Neonatal hypoxia 250.10 186.07 26 54 457 50604587

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Neonatal hypoxia 364.59 99.01 42 182 341 29573962

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
FDA MoA N0000000079 Surfactant Activity
FDA PE N0000008294 Alveolar Surface Tension Reduction
MeSH PA D011663 Pulmonary Surfactants
MeSH PA D019141 Respiratory System Agents
FDA EPC N0000175778 Surfactant

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Respiratory distress syndrome in the newborn indication 46775006




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
KE3U2023NP UNII
4021204 VANDF
C0771648 UMLSCUI
CHEMBL1201622 ChEMBL_ID
D08402 KEGG_DRUG
DB09113 DRUGBANK_ID
236381 RXNORM
31530 MMSL
8499 MMSL
d04496 MMSL
116075008 SNOMEDCT_US
386999001 SNOMEDCT_US
005782 NDDF
C068291 MESH_SUPPLEMENTAL_RECORD_UI

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Curosurf HUMAN PRESCRIPTION DRUG LABEL 1 10122-510 SUSPENSION 80 mg ENDOTRACHEAL BLA 19 sections
Curosurf HUMAN PRESCRIPTION DRUG LABEL 1 10122-510 SUSPENSION 80 mg ENDOTRACHEAL BLA 19 sections