gluconolactone Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
5144 90-80-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • gluconolactone
  • D-Gluconolactone
  • delta-gluconolactone
  • glucono delta-lactone
  • glucono-delta-lactone
  • Molecular weight: 178.14
  • Formula: C6H10O6
  • CLOGP: -2.23
  • LIPINSKI: 0
  • HAC: 6
  • HDO: 4
  • TPSA: 107.22
  • ALOGS: 0.52
  • ROTB: 1

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Oct. 2, 1990 FDA UNITED GUARDIAN

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
FDA MoA N0000175534 Irrigation
CHEBI has role CHEBI:75767 animal metabolites
CHEBI has role CHEBI:75771 mus musculus metabolite
FDA EPC N0000175835 Calculi Dissolution Agent

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Urinary bladder stone indication 70650003 DOID:11355

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 11.96 acidic
pKa2 12.58 acidic
pKa3 13.31 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Glucosylceramidase Enzyme Ki 4.52 CHEMBL

External reference:

IDSource
4019568 VANDF
C0061387 UMLSCUI
CHEBI:16217 CHEBI
LGC PDB_CHEM_ID
D04332 KEGG_DRUG
CHEMBL1200829 ChEMBL_ID
DB04564 DRUGBANK_ID
7027 PUBCHEM_CID
WQ29KQ9POT UNII
25842 RXNORM
NOCODE MMSL
d03715 MMSL
005159 NDDF
427638006 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Renacidin HUMAN PRESCRIPTION DRUG LABEL 3 0327-0012 SOLUTION 0.20 g IRRIGATION NDA 14 sections
DR.PLINUS ZERO TROUBLE HUMAN OTC DRUG LABEL 3 72630-030 PATCH 0.03 mg TOPICAL unapproved drug other 10 sections