interferon beta-1a 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
5139 145258-61-3

Description:

MoleculeDescription

Synonyms:

  • interferon beta-1a
  • avonex
An interferon beta-1 subtype that has a methionine at position 1, a cysteine at position 17, and is glycosylated at position 80. It functions as an ANTI-VIRAL AGENT and IMMUNOMODULATOR and is used to manage the symptoms of RELAPSING-REMITTING MULTIPLE SCLEROSIS. A possible role for IFNs in prophylaxis or early treatment of COVID-19 has been suggested to compensate for possibly insufficient endogenous IFN production. However, the efficacy and safety of IFNs for treatment or prevention of COVID-19 were not established.
  • Molecular weight:
  • Formula:
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA:
  • ALOGS:
  • ROTB: None

Drug dosage:

DoseUnitRoute
4.30 mcg P

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
March 13, 1997 EMA Biogen Netherlands B.V.
May 17, 1996 FDA BIOGEN

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Multiple sclerosis relapse 8943.40 11.63 3404 120066 45074 63320478
Influenza like illness 4896.71 11.63 2450 121020 64374 63301178
Fall 930.25 11.63 2227 121243 390107 62975445
General symptom 903.66 11.63 299 123171 2509 63363043
Injection site erythema 883.74 11.63 943 122527 82231 63283321
Off label use 848.47 11.63 147 123323 674315 62691237
Optic neuritis 812.32 11.63 374 123096 8061 63357491
Central nervous system lesion 767.81 11.63 387 123083 10248 63355304
Breast cancer 758.42 11.63 679 122791 47704 63317848
Gait disturbance 747.97 11.63 1304 122166 181874 63183678
Injection site pain 733.44 11.63 1072 122398 128728 63236824
Depression 623.79 11.63 1256 122214 195236 63170316
Memory impairment 551.27 11.63 835 122635 103423 63262129
Balance disorder 532.20 11.63 735 122735 83687 63281865
Seizure 470.58 11.63 889 122581 131745 63233807
Urinary tract infection 469.25 11.63 1350 122120 263334 63102218
Hypoaesthesia 468.28 11.63 1020 122450 167373 63198179
Injection site bruising 419.88 11.63 461 123009 41449 63324103
Contraindicated product administered 380.31 11.63 9 123461 217639 63147913
Diarrhoea 376.64 11.63 506 122964 714860 62650692
Loss of control of legs 375.72 11.63 130 123340 1266 63364286
Product use issue 367.65 11.63 14 123456 220506 63145046
Magnetic resonance imaging abnormal 348.62 11.63 153 123317 2932 63362620
Rash 345.15 11.63 350 123120 560521 62805031
Toxicity to various agents 344.66 11.63 39 123431 247211 63118341
Muscular weakness 344.29 11.63 745 122725 121608 63243944
Synovitis 341.99 11.63 4 123466 186914 63178638
Secondary progressive multiple sclerosis 323.58 11.63 117 123353 1310 63364242
Infusion related reaction 315.39 11.63 50 123420 245471 63120081
Injection site haematoma 305.13 11.63 181 123289 6651 63358901
Intervertebral disc protrusion 304.47 11.63 298 123172 23411 63342141
Joint swelling 301.63 11.63 130 123340 327536 63038016
Product use in unapproved indication 299.72 11.63 11 123459 179069 63186483
Glossodynia 286.16 11.63 15 123455 178861 63186691
Drug ineffective 283.36 11.63 1064 122406 1043701 62321851
Injection site reaction 278.76 11.63 447 123023 58077 63307475
Stress 269.33 11.63 475 122995 66692 63298860
Gait inability 265.35 11.63 414 123056 52545 63313007
Rheumatoid arthritis 261.54 11.63 84 123386 253735 63111817
Cognitive disorder 254.53 11.63 418 123052 55397 63310155
Dyspnoea 254.36 11.63 570 122900 660743 62704809
Uterine leiomyoma 251.28 11.63 179 123291 9019 63356533
Abdominal discomfort 249.89 11.63 158 123312 320727 63044825
Injection site haemorrhage 246.15 11.63 269 123201 24045 63341507
Abortion spontaneous 236.51 11.63 369 123101 46826 63318726
Chills 223.73 11.63 602 122868 112776 63252776
Decubitus ulcer 223.32 11.63 176 123294 10344 63355208
Drug interaction 221.97 11.63 84 123386 229047 63136505
Needle fatigue 220.70 11.63 51 123419 77 63365475
Injection site scar 217.93 11.63 80 123390 938 63364614
Hysterectomy 212.66 11.63 164 123306 9335 63356217
Ankle fracture 211.85 11.63 215 123255 17640 63347912
Peripheral swelling 205.53 11.63 132 123338 265810 63099742
Injection site necrosis 203.21 11.63 82 123388 1262 63364290
Trigeminal neuralgia 202.38 11.63 110 123360 3409 63362143
Muscle spasticity 193.12 11.63 225 123245 21569 63343983
Systemic lupus erythematosus 188.74 11.63 85 123385 208833 63156719
Neutropenia 185.43 11.63 55 123415 174950 63190602
Completed suicide 183.97 11.63 31 123439 145642 63219910
Febrile neutropenia 183.09 11.63 12 123458 118437 63247115
Pericarditis 182.61 11.63 21 123449 131558 63233994
Myocardial infarction 181.78 11.63 515 122955 99378 63266174
Peroneal nerve palsy 179.90 11.63 114 123356 4721 63360831
Drug hypersensitivity 179.36 11.63 204 123266 310483 63055069
Breast cancer female 178.89 11.63 173 123297 13386 63352166
Coronary artery occlusion 178.11 11.63 139 123331 8052 63357500
Urinary incontinence 176.93 11.63 262 123208 31752 63333800
Musculoskeletal disorder 176.07 11.63 209 123261 20435 63345117
Injection site infection 174.15 11.63 82 123388 1861 63363691
Stomatitis 174.13 11.63 30 123440 138695 63226857
Therapeutic product effect decreased 173.87 11.63 79 123391 193108 63172444
Acute kidney injury 172.50 11.63 155 123315 263260 63102292
Nausea 168.81 11.63 975 122495 853496 62512056
Intentional product use issue 166.48 11.63 25 123445 127867 63237685
Arthralgia 166.38 11.63 561 122909 569149 62796403
Cerebrovascular accident 165.42 11.63 524 122946 107500 63258052
Injection site abscess 163.76 11.63 68 123402 1130 63364422
Abdominal pain 162.60 11.63 199 123271 293257 63072295
Alopecia 158.14 11.63 258 123212 337278 63028274
Bladder disorder 154.98 11.63 133 123337 8813 63356739
Swelling 153.34 11.63 186 123284 275192 63090360
Therapeutic product effect incomplete 152.72 11.63 29 123441 125027 63240525
Diabetes mellitus 152.44 11.63 336 123134 55474 63310078
Injection site mass 146.27 11.63 181 123289 18475 63347077
Coordination abnormal 145.73 11.63 156 123314 13617 63351935
Injection site cellulitis 144.31 11.63 63 123407 1191 63364361
Caesarean section 142.89 11.63 171 123299 16861 63348691
Neuromyelitis optica spectrum disorder 142.38 11.63 59 123411 975 63364577
Helicobacter infection 141.63 11.63 10 123460 92775 63272777
Lower respiratory tract infection 141.19 11.63 41 123429 132266 63233286
Abortion 137.94 11.63 76 123394 2420 63363132
Malignant neoplasm progression 137.48 11.63 5 123465 82116 63283436
Pruritus 137.32 11.63 313 123157 361140 63004412
C-reactive protein increased 136.84 11.63 13 123457 94694 63270858
Road traffic accident 136.48 11.63 251 123219 36381 63329171
Injection site induration 133.70 11.63 124 123346 9102 63356450
Injection site atrophy 132.01 11.63 49 123421 594 63364958
Cough 131.32 11.63 230 123240 292513 63073039
Psoriatic arthropathy 131.08 11.63 13 123457 91507 63274045
Head injury 128.67 11.63 208 123262 27188 63338364
Progressive multiple sclerosis 128.51 11.63 57 123413 1121 63364431
Muscle spasms 127.33 11.63 621 122849 155529 63210023
Thyroid cancer 125.87 11.63 97 123373 5514 63360038
Post procedural complication 124.87 11.63 160 123310 16914 63348638
Hypotension 120.61 11.63 216 123254 272388 63093164
Neurogenic bladder 118.60 11.63 76 123394 3209 63362343
Tremor 117.34 11.63 539 122931 131700 63233852
Adverse reaction 115.84 11.63 120 123350 10083 63355469
Wound 115.52 11.63 89 123381 163174 63202378
Breast cancer in situ 115.07 11.63 57 123413 1451 63364101
Folliculitis 112.06 11.63 6 123464 70311 63295241
Multiple sclerosis 111.69 11.63 183 123287 24189 63341363
Blister 109.30 11.63 58 123412 129756 63235796
Hemiparesis 108.30 11.63 176 123294 23106 63342446
Malignant melanoma 106.94 11.63 121 123349 11235 63354317
Arthropathy 106.59 11.63 183 123287 234609 63130943
Maternal exposure timing unspecified 106.09 11.63 97 123373 6990 63358562
Pancytopenia 103.47 11.63 30 123440 96903 63268649
Muscle injury 102.82 11.63 6 123464 65339 63300213
Hip fracture 102.37 11.63 196 123274 29278 63336274
Decreased appetite 98.86 11.63 213 123257 250839 63114713
Hyponatraemia 98.70 11.63 47 123423 111853 63253699
Nephrolithiasis 98.37 11.63 238 123232 41746 63323806
Visual impairment 97.39 11.63 373 123097 84073 63281479
Blindness unilateral 96.52 11.63 87 123383 6154 63359398
Relapsing-remitting multiple sclerosis 96.16 11.63 38 123432 552 63365000
Phobia 95.40 11.63 33 123437 321 63365231
Wheezing 94.24 11.63 34 123436 95561 63269991
Intracranial aneurysm 93.55 11.63 69 123401 3670 63361882
Drug delivery device placement 90.88 11.63 25 123445 101 63365451
Blood creatinine increased 90.49 11.63 29 123441 87815 63277737
Asthenia 89.20 11.63 1138 122332 382466 62983086
Electrocardiogram QT prolonged 89.18 11.63 7 123463 59523 63306029
Loss of personal independence in daily activities 88.70 11.63 39 123431 97251 63268301
Hyperkalaemia 88.37 11.63 4 123466 54199 63311353
Drug abuse 88.12 11.63 17 123453 72501 63293051
Cystitis 88.03 11.63 271 123199 54720 63310832
Upper limb fracture 87.69 11.63 143 123327 18825 63346727
Therapeutic response decreased 87.41 11.63 9 123461 61516 63304036
Discomfort 86.93 11.63 119 123351 167255 63198297
Injection site discolouration 86.76 11.63 91 123379 7757 63357795
Oedema 86.10 11.63 41 123429 97581 63267971
Adverse drug reaction 85.36 11.63 344 123126 79370 63286182
Cholelithiasis 85.31 11.63 232 123238 43693 63321859
Paraesthesia 84.71 11.63 559 122911 156407 63209145
Mobility decreased 84.24 11.63 461 123009 120698 63244854
Ovarian cancer 84.05 11.63 79 123391 5897 63359655
Hypokalaemia 82.19 11.63 50 123420 103754 63261798
Amnesia 81.72 11.63 266 123204 55319 63310233
Sensory disturbance 81.50 11.63 116 123354 13556 63351996
Staphylococcal infection 80.22 11.63 218 123252 41038 63324514
Procedural anxiety 79.71 11.63 36 123434 740 63364812
Vomiting 76.07 11.63 709 122761 558908 62806644
General physical health deterioration 75.07 11.63 176 123294 201226 63164326
Migraine 73.70 11.63 396 123074 102950 63262602
Lower limb fracture 73.22 11.63 152 123318 24069 63341483
Drug specific antibody present 73.12 11.63 63 123407 4196 63361356
Thrombosis 72.99 11.63 284 123186 64471 63301081
Psoriasis 72.97 11.63 39 123431 86918 63278634
Neutralising antibodies positive 72.56 11.63 25 123445 240 63365312
Lung neoplasm malignant 72.46 11.63 134 123336 19499 63346053
Oxygen saturation decreased 71.06 11.63 42 123428 88543 63277009
Injection site nodule 70.50 11.63 59 123411 3776 63361776
Dysgraphia 70.39 11.63 55 123415 3191 63362361
Thrombocytopenia 70.23 11.63 116 123354 151041 63214511
Dysstasia 70.14 11.63 138 123332 21028 63344524
Kidney infection 69.54 11.63 145 123325 23031 63342521
Suicidal ideation 68.93 11.63 272 123198 62149 63303403
Injection site ulcer 68.67 11.63 30 123440 568 63364984
Speech disorder 68.57 11.63 204 123266 40425 63325127
Generalised tonic-clonic seizure 68.52 11.63 165 123305 28851 63336701
Anaemia 68.15 11.63 316 123154 293114 63072438
Appendicitis 68.00 11.63 82 123388 8147 63357405
Haemoglobin decreased 67.26 11.63 112 123358 145373 63220179
Meningioma benign 67.20 11.63 25 123445 305 63365247
Interstitial lung disease 66.36 11.63 19 123451 61889 63303663
Mucosal inflammation 66.32 11.63 7 123463 46921 63318631
Mental impairment 65.84 11.63 107 123363 14044 63351508
Dyspnoea exertional 65.58 11.63 18 123452 60284 63305268
Temperature intolerance 65.54 11.63 84 123386 8880 63356672
Anxiety 64.15 11.63 676 122794 216865 63148687
Invasive ductal breast carcinoma 63.58 11.63 73 123397 6885 63358667
Feeling abnormal 63.58 11.63 500 122970 147892 63217660
COVID-19 63.28 11.63 76 123394 113027 63252525
Blindness 63.06 11.63 134 123336 21565 63343987
Intervertebral disc disorder 62.39 11.63 61 123409 4782 63360770
Pleural effusion 61.94 11.63 54 123416 93156 63272396
Hospitalisation 61.93 11.63 45 123425 85036 63280516
Aphasia 61.79 11.63 172 123298 32828 63332724
Tachycardia 61.34 11.63 84 123386 118072 63247480
Intentional overdose 61.13 11.63 34 123436 74118 63291434
Injury associated with device 60.46 11.63 53 123417 3613 63361939
Influenza 60.33 11.63 390 123080 108332 63257220
Treatment failure 59.23 11.63 194 123276 198849 63166703
Metabolic acidosis 58.19 11.63 9 123461 45060 63320492
Gastric bypass 58.19 11.63 39 123431 1778 63363774
Sinusitis 58.15 11.63 235 123235 226418 63139134
Spinal stenosis 57.78 11.63 104 123366 14821 63350731
Scar 57.18 11.63 99 123371 13683 63351869
Diplopia 57.18 11.63 136 123334 23592 63341960
Epilepsy 56.65 11.63 147 123323 26918 63338634
Productive cough 56.57 11.63 26 123444 63182 63302370
Autoimmune hepatitis 56.42 11.63 76 123394 8434 63357118
Cervix carcinoma 56.40 11.63 47 123423 2990 63362562
Lack of injection site rotation 56.05 11.63 24 123446 432 63365120
Lactic acidosis 55.97 11.63 5 123465 38282 63327270
Endometriosis 55.82 11.63 60 123410 5260 63360292
Cervical spinal stenosis 55.81 11.63 41 123429 2167 63363385
Blood pressure systolic increased 55.74 11.63 12 123458 47385 63318167
Ligament rupture 55.39 11.63 49 123421 3381 63362171
Lumbar spinal stenosis 55.26 11.63 57 123413 4765 63360787
Basedow's disease 54.04 11.63 21 123449 291 63365261
Agraphia 53.95 11.63 13 123457 26 63365526
Intraductal proliferative breast lesion 53.50 11.63 45 123425 2900 63362652
Hypoglycaemia 53.30 11.63 25 123445 60040 63305512
Appendicitis perforated 53.20 11.63 37 123433 1793 63363759
Concussion 53.00 11.63 77 123393 9167 63356385
Neuropathy peripheral 53.00 11.63 87 123383 113580 63251972
Cholecystectomy 52.79 11.63 83 123387 10594 63354958
Primary progressive multiple sclerosis 52.69 11.63 16 123454 98 63365454
Neutrophil count decreased 52.38 11.63 22 123448 56384 63309168
Condition aggravated 52.25 11.63 515 122955 401702 62963850
Therapy non-responder 51.62 11.63 43 123427 75858 63289694
Retinal exudates 51.50 11.63 26 123444 690 63364862
Meningioma 50.17 11.63 49 123421 3836 63361716
Intentional product misuse 50.11 11.63 28 123442 60889 63304663
Multiple organ dysfunction syndrome 49.78 11.63 24 123446 56728 63308824
Medication error 49.18 11.63 20 123450 52264 63313288
Bradycardia 49.17 11.63 42 123428 73185 63292367
Nasal congestion 48.74 11.63 34 123436 65626 63299926
Clostridial infection 48.68 11.63 51 123419 4341 63361211
Irritable bowel syndrome 48.67 11.63 53 123417 82359 63283193
Ovarian cyst 48.12 11.63 100 123370 15845 63349707
Paralysis 47.62 11.63 76 123394 9824 63355728
Inflammation 47.39 11.63 54 123416 82219 63283333
Injection site scab 47.34 11.63 21 123449 413 63365139
Postoperative wound infection 47.33 11.63 80 123390 10845 63354707
Dyspepsia 46.92 11.63 79 123391 102117 63263435
Red blood cell sedimentation rate increased 46.22 11.63 14 123456 43968 63321584
Illness 45.77 11.63 19 123451 49040 63316512
Renal impairment 45.66 11.63 63 123407 88292 63277260
Injury 45.63 11.63 45 123425 73202 63292350
Sedation 45.28 11.63 10 123460 38799 63326753
Colon cancer 45.02 11.63 74 123396 9804 63355748
Thyroid disorder 44.48 11.63 94 123376 15068 63350484
Constipation 44.43 11.63 256 123214 224687 63140865
Intervertebral disc degeneration 44.39 11.63 96 123374 15636 63349916
Depressed mood 44.25 11.63 175 123295 40016 63325536
Hypertension 44.21 11.63 776 122694 278527 63087025
Hypocalcaemia 44.13 11.63 5 123465 31708 63333844
Mouth ulceration 43.94 11.63 6 123464 32978 63332574
Liver function test abnormal 43.88 11.63 198 123272 47983 63317569
Uterine cancer 43.83 11.63 50 123420 4683 63360869
Focal dyscognitive seizures 43.76 11.63 40 123430 2881 63362671
Bipolar disorder 43.75 11.63 65 123405 7895 63357657
Cardiac failure 43.67 11.63 66 123404 89076 63276476
Pulmonary thrombosis 43.51 11.63 68 123402 8634 63356918
Somnolence 43.50 11.63 189 123281 178496 63187056
Breast cancer stage I 43.36 11.63 60 123410 6829 63358723
International normalised ratio increased 43.28 11.63 18 123452 46407 63319145
Malaise 43.12 11.63 1086 122384 414868 62950684
Hypoxia 43.02 11.63 32 123438 59760 63305792
Frustration tolerance decreased 42.70 11.63 60 123410 6928 63358624
Ruptured cerebral aneurysm 42.47 11.63 20 123450 454 63365098
Paraparesis 42.18 11.63 35 123435 2213 63363339
Autoimmune thyroiditis 41.90 11.63 45 123425 3941 63361611
Neoplasm malignant 41.29 11.63 140 123330 29721 63335831
Micturition urgency 41.13 11.63 70 123400 9541 63356011
Overdose 40.93 11.63 103 123367 114975 63250577
Weight increased 40.88 11.63 318 123152 260474 63105078
Abdominal pain upper 40.73 11.63 235 123235 206209 63159343
Haematochezia 40.71 11.63 27 123443 53517 63312035
Burning sensation 40.49 11.63 211 123259 54196 63311356
Product quality issue 40.34 11.63 10 123460 35855 63329697
Injection site calcification 40.26 11.63 10 123460 24 63365528
Depressed level of consciousness 40.00 11.63 37 123433 62041 63303511
Surgery 39.24 11.63 156 123314 35756 63329796
Motor dysfunction 39.15 11.63 73 123397 10688 63354864
Platelet count decreased 38.96 11.63 107 123363 116015 63249537
Vision blurred 38.94 11.63 309 123161 91615 63273937
Paraplegia 38.88 11.63 36 123434 2636 63362916
Band sensation 38.64 11.63 23 123447 850 63364702
Ectopic pregnancy 38.16 11.63 35 123435 2532 63363020
Muscle atrophy 38.04 11.63 57 123413 6976 63358576
Papillary thyroid cancer 37.98 11.63 33 123437 2223 63363329
Gastrointestinal haemorrhage 37.96 11.63 62 123408 81114 63284438
Ataxia 37.59 11.63 88 123382 15107 63350445
Meniscus injury 37.55 11.63 57 123413 7057 63358495
Tibia fracture 37.46 11.63 48 123422 5072 63360480
Cardio-respiratory arrest 37.16 11.63 37 123433 59922 63305630
Procedural pain 37.06 11.63 109 123361 21460 63344092
Erythema 36.89 11.63 196 123274 175555 63189997
Procedural complication 36.71 11.63 49 123421 5390 63360162
Accidental exposure to product 36.47 11.63 5 123465 27400 63338152
Neutralising antibodies 36.43 11.63 10 123460 40 63365512
Brain neoplasm benign 36.16 11.63 14 123456 192 63365360
Sarcoidosis 36.09 11.63 56 123414 7066 63358486
Injection site injury 36.04 11.63 20 123450 646 63364906
Benign breast neoplasm 35.88 11.63 25 123445 1215 63364337
Feeling cold 35.71 11.63 115 123355 23773 63341779
Reaction to preservatives 35.14 11.63 14 123456 208 63365344
Gallbladder disorder 35.07 11.63 98 123372 18744 63346808
Septic shock 34.94 11.63 47 123423 66582 63298970
Nerve compression 34.76 11.63 63 123407 9024 63356528
Bladder dysfunction 34.69 11.63 22 123448 912 63364640
Appendicectomy 34.14 11.63 35 123435 2904 63362648
Incorrect dose administered 33.84 11.63 40 123430 59928 63305624
Injection site fibrosis 33.54 11.63 8 123462 15 63365537
Myelitis transverse 33.22 11.63 24 123446 1236 63364316
Thyroid neoplasm 33.13 11.63 40 123430 3979 63361573
Prolonged labour 32.99 11.63 18 123452 562 63364990
Decreased immune responsiveness 32.84 11.63 44 123426 4857 63360695
Rhinorrhoea 32.65 11.63 48 123422 65529 63300023
Rash pruritic 32.57 11.63 41 123429 59758 63305794
Fear 32.34 11.63 85 123385 15681 63349871
Cellulitis 32.28 11.63 271 123199 81687 63283865
Serotonin syndrome 32.25 11.63 8 123462 28674 63336878
Vertigo 32.09 11.63 213 123257 59674 63305878
Drug ineffective for unapproved indication 32.09 11.63 13 123457 34050 63331502
Brain neoplasm 32.05 11.63 41 123429 4325 63361227
Breech presentation 31.72 11.63 23 123447 1191 63364361
Blood creatine phosphokinase increased 31.41 11.63 10 123460 30420 63335132
Rotator cuff syndrome 31.04 11.63 76 123394 13426 63352126
Drug resistance 30.96 11.63 4 123466 22929 63342623
Mammoplasty 30.78 11.63 17 123453 544 63365008
Anal incontinence 30.77 11.63 76 123394 13500 63352052
Pneumonitis 30.73 11.63 15 123455 35207 63330345
Dry mouth 30.65 11.63 66 123404 77797 63287755
Prescribed overdose 30.63 11.63 14 123456 34139 63331413
Drug level increased 30.61 11.63 4 123466 22732 63342820
Optic nerve disorder 30.49 11.63 20 123450 879 63364673
Product administered at inappropriate site 30.41 11.63 34 123436 3115 63362437
Central venous catheterisation 30.28 11.63 31 123439 2568 63362984
Pulmonary sarcoidosis 30.11 11.63 21 123449 1022 63364530
Haemorrhage in pregnancy 30.09 11.63 27 123443 1898 63363654
Oral pain 29.90 11.63 9 123461 28385 63337167
Expanded disability status scale score increased 29.82 11.63 17 123453 579 63364973
Full blood count decreased 29.77 11.63 7 123463 26017 63339535
Injection site inflammation 29.66 11.63 37 123433 3806 63361746
Mental disorder 29.46 11.63 114 123356 25805 63339747
Gastrointestinal disorder 29.44 11.63 143 123327 131096 63234456
Haemolytic uraemic syndrome 29.43 11.63 30 123440 2473 63363079
Injection site irritation 29.32 11.63 42 123428 4936 63360616
Raynaud's phenomenon 29.31 11.63 22 123448 1202 63364350
Delirium 29.29 11.63 33 123437 50508 63315044
Oedema peripheral 29.25 11.63 232 123238 189279 63176273
Varicose vein 29.21 11.63 42 123428 4953 63360599
Drug dependence 29.19 11.63 6 123464 24477 63341075
Hepatitis C 28.89 11.63 43 123427 5231 63360321
Benign lung neoplasm 28.86 11.63 9 123461 61 63365491
Frequent bowel movements 28.82 11.63 5 123465 23017 63342535
Diplegia 28.82 11.63 21 123449 1096 63364456
Pain in extremity 28.77 11.63 846 122624 330640 63034912
Blood potassium decreased 28.57 11.63 159 123311 41867 63323685
Blood calcium decreased 28.56 11.63 8 123462 26443 63339109
Rhabdomyolysis 28.55 11.63 26 123444 43925 63321627
Bladder cancer 28.53 11.63 44 123426 5522 63360030
JC polyomavirus test 28.39 11.63 8 123462 36 63365516
Product prescribing error 28.29 11.63 8 123462 26281 63339271
Agranulocytosis 28.28 11.63 7 123463 25127 63340425
Hypersensitivity 28.21 11.63 400 123070 292285 63073267
Hypervolaemia 28.17 11.63 10 123460 28403 63337149
Porphyria non-acute 28.06 11.63 13 123457 284 63365268
Myelosuppression 27.87 11.63 6 123464 23697 63341855
No adverse event 27.71 11.63 156 123314 41249 63324303
Liver injury 27.57 11.63 47 123423 60473 63305079
Back disorder 27.47 11.63 64 123406 10953 63354599
Muscle tightness 27.37 11.63 67 123403 11833 63353719
Dysarthria 27.33 11.63 159 123311 42552 63323000
Obstructive airways disorder 27.02 11.63 4 123466 20695 63344857
Dry skin 27.01 11.63 43 123427 56844 63308708
Heavy menstrual bleeding 26.97 11.63 86 123384 17687 63347865
Chronic leukaemia 26.84 11.63 6 123464 7 63365545
Coronary artery disease 26.51 11.63 129 123341 32248 63333304
Thyroid function test abnormal 26.38 11.63 34 123436 3613 63361939
Cellulitis staphylococcal 26.25 11.63 17 123453 731 63364821
Blood pressure diastolic decreased 26.19 11.63 6 123464 22700 63342852
Vitamin D decreased 26.09 11.63 60 123410 10182 63355370
Retinal tear 26.07 11.63 21 123449 1273 63364279
Colon cancer stage III 26.03 11.63 10 123460 134 63365418
Blood pressure fluctuation 26.02 11.63 31 123439 46286 63319266
Panic attack 26.02 11.63 99 123371 22232 63343320
Febrile convulsion 25.87 11.63 14 123456 430 63365122
Rash maculo-papular 25.75 11.63 15 123455 31881 63333671
Fibula fracture 25.59 11.63 33 123437 3509 63362043
Neuralgia 25.47 11.63 109 123361 25817 63339735
Musculoskeletal stiffness 25.36 11.63 233 123237 184385 63181167
Cytomegalovirus infection 25.26 11.63 5 123465 20947 63344605
Rectocele 25.25 11.63 19 123451 1042 63364510
Uterine disorder 25.24 11.63 31 123439 3138 63362414
Ligament sprain 25.24 11.63 68 123402 12732 63352820
Headache 25.11 11.63 1487 121983 631754 62733798
Endometrial cancer 24.81 11.63 31 123439 3194 63362358
Hypercalcaemia 24.80 11.63 12 123458 28310 63337242
Bone marrow failure 24.76 11.63 13 123457 29277 63336275
Loss of consciousness 24.68 11.63 344 123126 117777 63247775
Abdominal distension 24.66 11.63 86 123384 86529 63279023
Breast cancer recurrent 24.66 11.63 36 123434 4305 63361247
Hemianaesthesia 24.54 11.63 13 123457 382 63365170
Lung adenocarcinoma 24.50 11.63 37 123433 4560 63360992
Wound infection staphylococcal 24.36 11.63 28 123442 2644 63362908
Eosinophilia 24.35 11.63 7 123463 22749 63342803
Infection 24.32 11.63 307 123163 228866 63136686
Breast cancer stage II 24.29 11.63 53 123417 8683 63356869
Conversion disorder 24.20 11.63 23 123447 1741 63363811
Blindness transient 24.15 11.63 33 123437 3711 63361841
Bone erosion 24.14 11.63 3 123467 17714 63347838
Inappropriate schedule of product administration 24.06 11.63 112 123358 103853 63261699
Demyelination 24 11.63 46 123424 6874 63358678
Angioedema 23.99 11.63 35 123435 47930 63317622
Fluid retention 23.98 11.63 50 123420 59636 63305916
Calculus bladder 23.87 11.63 15 123455 612 63364940
Cartilage injury 23.80 11.63 24 123446 1953 63363599
Joint range of motion decreased 23.79 11.63 17 123453 32411 63333141
Poor venous access 23.78 11.63 73 123397 14712 63350840
Injection site anaesthesia 23.76 11.63 7 123463 38 63365514
Goitre 23.66 11.63 42 123428 5919 63359633
Anaphylactic reaction 23.62 11.63 59 123411 66041 63299511
Cholestasis 23.53 11.63 14 123456 29420 63336132
Pollakiuria 23.37 11.63 112 123358 27825 63337727
Scoliosis 23.25 11.63 49 123421 7839 63357713
Agitation 23.23 11.63 51 123419 59706 63305846
Dry eye 23.20 11.63 27 123443 40734 63324818
Chronic lymphocytic leukaemia 23.17 11.63 27 123443 2587 63362965
Incontinence 23.14 11.63 62 123408 11570 63353982
Impaired self-care 23.06 11.63 23 123447 1847 63363705
Hernia 23.01 11.63 65 123405 12509 63353043
Partial seizures 22.98 11.63 41 123429 5801 63359751
Suicidal behaviour 22.96 11.63 27 123443 2612 63362940
Fear of injection 22.88 11.63 46 123424 7118 63358434
Nerve injury 22.88 11.63 56 123414 9890 63355662
Respiratory failure 22.83 11.63 111 123359 101747 63263805
Pneumocystis jirovecii pneumonia 22.71 11.63 3 123467 16911 63348641
Lung adenocarcinoma stage I 22.71 11.63 6 123464 20 63365532
Wrist fracture 22.71 11.63 68 123402 13519 63352033
Lung disorder 22.70 11.63 55 123415 62206 63303346
Deafness unilateral 22.61 11.63 29 123441 3067 63362485
Pain in jaw 22.48 11.63 31 123439 43465 63322087
Throat irritation 22.46 11.63 24 123446 37623 63327929
Renal cell carcinoma 22.44 11.63 30 123440 3305 63362247
Emotional disorder 22.40 11.63 67 123403 13312 63352240
Oropharyngeal pain 22.34 11.63 101 123369 94386 63271166
Foot fracture 22.32 11.63 99 123371 23815 63341737
Urosepsis 22.31 11.63 83 123387 18441 63347111
Urinary tract disorder 22.20 11.63 28 123442 2913 63362639
Gallbladder operation 22.12 11.63 25 123445 2318 63363234
Ascites 22.10 11.63 28 123442 40700 63324852
Lumbar radiculopathy 22.07 11.63 23 123447 1946 63363606
Anti-interferon antibody positive 22.06 11.63 6 123464 23 63365529
Crying 22.06 11.63 97 123373 23246 63342306
Pulmonary fibrosis 21.99 11.63 27 123443 39782 63325770
Thermal burn 21.97 11.63 41 123429 6005 63359547
JC polyomavirus test positive 21.97 11.63 20 123450 1433 63364119
Post procedural haemorrhage 21.79 11.63 48 123422 7916 63357636
Cervical dysplasia 21.76 11.63 29 123441 3185 63362367
Intervertebral disc operation 21.69 11.63 16 123454 851 63364701
Creatinine renal clearance decreased 21.64 11.63 3 123467 16305 63349247
Intervertebral disc injury 21.49 11.63 9 123461 153 63365399
Tachypnoea 21.13 11.63 4 123466 17298 63348254
Lipoatrophy 21.12 11.63 11 123459 312 63365240
Cholecystitis infective 21.11 11.63 21 123449 1681 63363871
Spondylolisthesis 21.07 11.63 30 123440 3506 63362046
Hepatic steatosis 21.01 11.63 111 123359 28658 63336894
Oral candidiasis 20.99 11.63 9 123461 22789 63342763
Fractured coccyx 20.94 11.63 17 123453 1042 63364510
Spinal disorder 20.94 11.63 54 123416 9848 63355704
Abnormal labour 20.92 11.63 7 123463 61 63365491
Fat necrosis 20.74 11.63 14 123456 646 63364906
Dysgeusia 20.62 11.63 37 123433 46673 63318879
Haemorrhagic adrenal infarction 20.61 11.63 6 123464 31 63365521
Rubber sensitivity 20.53 11.63 24 123446 2307 63363245
Orthostatic hypotension 20.53 11.63 24 123446 36136 63329416
Anaesthetic complication 20.38 11.63 22 123448 1938 63363614
Rash erythematous 20.31 11.63 32 123438 42478 63323074
Cholecystitis 20.30 11.63 71 123399 15306 63350246
Atrial fibrillation 20.28 11.63 138 123332 116498 63249054
Lip dry 20.17 11.63 3 123467 15467 63350085
Benign hydatidiform mole 20.13 11.63 8 123462 118 63365434
Limb mass 20.12 11.63 28 123442 3204 63362348
Feeling of body temperature change 20.08 11.63 35 123435 4862 63360690
Schwannoma 20.06 11.63 7 123463 70 63365482
Impaired healing 20.06 11.63 117 123353 102425 63263127
Relapsing multiple sclerosis 20.02 11.63 9 123461 183 63365369
Chronic kidney disease 20.00 11.63 36 123434 45362 63320190
Withdrawal syndrome 19.89 11.63 7 123463 19990 63345562
Precancerous cells present 19.88 11.63 19 123451 1448 63364104
Focal segmental glomerulosclerosis 19.87 11.63 19 123451 1449 63364103
Basal cell carcinoma 19.76 11.63 107 123363 27884 63337668
Facial bones fracture 19.75 11.63 31 123439 3951 63361601
Tubulointerstitial nephritis 19.74 11.63 7 123463 19896 63345656
Progesterone receptor assay positive 19.72 11.63 11 123459 359 63365193
Knee operation 19.67 11.63 39 123431 5974 63359578
Umbilical cord around neck 19.62 11.63 9 123461 192 63365360
Gait spastic 19.52 11.63 10 123460 274 63365278
Acute respiratory failure 19.46 11.63 23 123447 34462 63331090
Drug intolerance 19.28 11.63 455 123015 308206 63057346
Haematuria 19.23 11.63 17 123453 29140 63336412
Thrombotic thrombocytopenic purpura 19.21 11.63 30 123440 3806 63361746
Colostomy closure 19.21 11.63 8 123462 134 63365418
Skin exfoliation 19.15 11.63 34 123436 43068 63322484
Incision site complication 19.01 11.63 13 123457 613 63364939
Cephalo-pelvic disproportion 19.00 11.63 9 123461 207 63365345
Atrophy 19.00 11.63 20 123450 1712 63363840
Fibromyalgia 18.99 11.63 86 123384 80334 63285218
Rectal haemorrhage 18.93 11.63 42 123428 48988 63316564
Product substitution issue 18.91 11.63 4 123466 15992 63349560
Oestrogen receptor assay positive 18.87 11.63 12 123458 500 63365052
Urinary retention 18.86 11.63 112 123358 30189 63335363
Foetal heart rate abnormal 18.80 11.63 13 123457 624 63364928
Sleep disorder 18.80 11.63 88 123382 81478 63284074
Ovarian neoplasm 18.79 11.63 15 123455 898 63364654
Arterial occlusive disease 18.72 11.63 38 123432 5920 63359632
Skin cancer 18.71 11.63 57 123413 11438 63354114
Ocular hyperaemia 18.68 11.63 13 123457 25131 63340421
Rectal cancer 18.65 11.63 22 123448 2136 63363416
Face oedema 18.58 11.63 8 123462 20204 63345348
Hepatotoxicity 18.55 11.63 27 123443 37014 63328538
Malignant melanoma in situ 18.51 11.63 15 123455 917 63364635
Volvulus 18.49 11.63 20 123450 1766 63363786
Gun shot wound 18.43 11.63 8 123462 149 63365403
Aneurysm 18.32 11.63 25 123445 2808 63362744
Magnetic resonance imaging head abnormal 18.19 11.63 21 123449 1992 63363560
Incisional hernia 18.18 11.63 19 123451 1613 63363939
Optic atrophy 18.17 11.63 17 123453 1261 63364291
Breast calcifications 18.17 11.63 17 123453 1261 63364291
Incoherent 18.09 11.63 32 123438 4498 63361054
Injection site swelling 18.04 11.63 156 123314 47416 63318136
Cerebral atrophy 17.97 11.63 34 123436 5032 63360520
Oophorectomy 17.92 11.63 12 123458 546 63365006
Cardiac disorder 17.91 11.63 164 123306 50652 63314900
Hand fracture 17.88 11.63 36 123434 5577 63359975
Eye pruritus 17.79 11.63 7 123463 18664 63346888
Post procedural infection 17.79 11.63 49 123421 9293 63356259
Large intestine polyp 17.79 11.63 45 123425 8112 63357440
Intervertebral disc displacement 17.74 11.63 11 123459 438 63365114
Gastric cyst 17.69 11.63 7 123463 102 63365450
Post procedural stroke 17.66 11.63 6 123464 55 63365497
Drug tolerance decreased 17.58 11.63 6 123464 17467 63348085
Haemorrhagic ovarian cyst 17.48 11.63 13 123457 700 63364852
Fibrocystic breast disease 17.23 11.63 16 123454 1176 63364376
Muscle disorder 17.20 11.63 33 123437 4936 63360616
Endometrial cancer stage I 17.19 11.63 9 123461 258 63365294
Female genital operation 17.15 11.63 5 123465 26 63365526
Musculoskeletal pain 17.15 11.63 107 123363 92170 63273382
Umbilical hernia 17.13 11.63 25 123445 2989 63362563
Cardiac perforation 17.11 11.63 6 123464 61 63365491
Homicidal ideation 17.06 11.63 19 123451 1733 63363819
Injection site hypertrophy 17.02 11.63 6 123464 62 63365490
Enterocele 16.85 11.63 6 123464 64 63365488
Myelitis 16.83 11.63 17 123453 1386 63364166
Nodule 16.81 11.63 10 123460 21016 63344536
Hyperaesthesia 16.76 11.63 48 123422 9310 63356242
Cervical vertebral fracture 16.67 11.63 23 123447 2611 63362941
Skin graft 16.63 11.63 12 123458 617 63364935
Adrenal insufficiency 16.61 11.63 7 123463 17908 63347644
Epistaxis 16.44 11.63 79 123391 72646 63292906
Viral pericarditis 16.41 11.63 5 123465 31 63365521
Skull fracture 16.41 11.63 15 123455 1080 63364472
Vein disorder 16.41 11.63 33 123437 5108 63360444
Haemoptysis 16.38 11.63 19 123451 28707 63336845
Cerebral cyst 16.35 11.63 9 123461 286 63365266
Lipodystrophy acquired 16.34 11.63 17 123453 1435 63364117
Tumefactive multiple sclerosis 16.29 11.63 6 123464 71 63365481
Lacrimation increased 16.23 11.63 10 123460 20621 63344931
Osteoarthritis 16.17 11.63 268 123202 95075 63270477
Injection site rash 16.16 11.63 76 123394 18733 63346819
Acute disseminated encephalomyelitis 16.14 11.63 8 123462 204 63365348
Ovarian cancer stage III 16.13 11.63 9 123461 294 63365258
Hyperglycaemia 16.05 11.63 36 123434 41831 63323721
Uterine mass 16.01 11.63 9 123461 298 63365254
Chondropathy 15.95 11.63 21 123449 2279 63363273
Lyme disease 15.94 11.63 26 123444 3423 63362129
Drug delivery system malfunction 15.90 11.63 15 123455 1125 63364427
Cerebral thrombosis 15.89 11.63 18 123452 1673 63363879
Visual acuity reduced 15.79 11.63 84 123386 21742 63343810
Colon cancer metastatic 15.77 11.63 15 123455 1136 63364416
Spider vein 15.77 11.63 9 123461 307 63365245
Neurological complication associated with device 15.73 11.63 3 123467 0 63365552
Neurilemmoma benign 15.73 11.63 3 123467 0 63365552
Biopsy bladder 15.73 11.63 3 123467 0 63365552
Breast dysplasia 15.73 11.63 3 123467 0 63365552
Rectal cancer stage I 15.73 11.63 3 123467 0 63365552
Urinary control neurostimulator implantation 15.73 11.63 3 123467 0 63365552
Face presentation 15.73 11.63 3 123467 0 63365552
Rib fracture 15.69 11.63 86 123384 22511 63343041
Pregnancy 15.68 11.63 124 123346 36712 63328840
Abortion missed 15.65 11.63 18 123452 1701 63363851
Glioblastoma 15.64 11.63 13 123457 824 63364728
Lung cancer metastatic 15.54 11.63 22 123448 2558 63362994
Heat stroke 15.49 11.63 13 123457 835 63364717
Skin laceration 15.49 11.63 86 123384 22622 63342930
Heat exhaustion 15.45 11.63 7 123463 145 63365407
Suture rupture 15.42 11.63 8 123462 225 63365327
Haematemesis 15.39 11.63 22 123448 30390 63335162
Pneumonia 15.38 11.63 1058 122412 455709 62909843
Rales 15.37 11.63 3 123467 12694 63352858
Facial paralysis 15.34 11.63 61 123409 13980 63351572
Disseminated intravascular coagulation 15.32 11.63 9 123461 19042 63346510
Joint effusion 15.29 11.63 7 123463 17053 63348499
Reproductive tract disorder 15.27 11.63 7 123463 149 63365403
Pancreatic cyst 15.24 11.63 17 123453 1553 63363999
Exposure during pregnancy 15.17 11.63 212 123258 155335 63210217
Malignant hypertension 15.11 11.63 15 123455 1198 63364354
Paternal exposure before pregnancy 15.10 11.63 5 123465 42 63365510
Skin indentation 15.10 11.63 5 123465 42 63365510
Shock 15.09 11.63 14 123456 23449 63342103
Tenderness 15.09 11.63 13 123457 22565 63342987
Ill-defined disorder 15.09 11.63 95 123375 81660 63283892
Upper gastrointestinal haemorrhage 15.03 11.63 9 123461 18843 63346709
Carotid artery aneurysm 15.01 11.63 9 123461 337 63365215
Asthma 15.01 11.63 167 123303 127394 63238158
Bursitis 14.90 11.63 31 123439 37010 63328542
Endometrial adenocarcinoma 14.87 11.63 15 123455 1221 63364331
Product administration error 14.84 11.63 13 123457 22384 63343168
Meningitis viral 14.77 11.63 16 123454 1415 63364137
Hypothyroidism 14.73 11.63 137 123333 42495 63323057
Brain operation 14.70 11.63 11 123459 598 63364954
Leukopenia 14.68 11.63 89 123381 77201 63288351
Cervix carcinoma stage 0 14.62 11.63 9 123461 354 63365198
Nephrotic syndrome 14.57 11.63 33 123437 5543 63360009
Sleep disorder due to a general medical condition 14.50 11.63 3 123467 12185 63353367
Limb injury 14.49 11.63 92 123378 25385 63340167
Plasma cell myeloma 14.49 11.63 30 123440 35875 63329677
Joint stiffness 14.47 11.63 38 123432 41831 63323721
Ophthalmoplegia 14.47 11.63 16 123454 1448 63364104
Spinal cord disorder 14.42 11.63 15 123455 1266 63364286
Uterine leiomyosarcoma 14.38 11.63 4 123466 17 63365535
Urinary tract infection staphylococcal 14.37 11.63 9 123461 365 63365187
Postoperative thrombosis 14.36 11.63 7 123463 172 63365380
Injection site hypoaesthesia 14.33 11.63 10 123460 487 63365065
Incision site abscess 14.32 11.63 9 123461 367 63365185
Exposure via father 14.26 11.63 8 123462 264 63365288
Hypoacusis 14.23 11.63 88 123382 24063 63341489
Ovarian germ cell teratoma benign 14.22 11.63 6 123464 104 63365448
Osteonecrosis 14.21 11.63 89 123381 24441 63341111
Abdominal operation 14.20 11.63 11 123459 630 63364922
Normal newborn 14.18 11.63 42 123428 8299 63357253
Spinal meningeal cyst 14.16 11.63 5 123465 52 63365500
Serum serotonin decreased 14.02 11.63 4 123466 19 63365533
Amniotic fluid volume decreased 14.00 11.63 10 123460 506 63365046
Right ventricular failure 13.99 11.63 8 123462 17180 63348372
Pulmonary oedema 13.98 11.63 57 123413 54816 63310736
Injection related reaction 13.96 11.63 12 123458 797 63364755
Wrong technique in product usage process 13.93 11.63 68 123402 62272 63303280
Bladder prolapse 13.90 11.63 19 123451 2137 63363415
Bronchiectasis 13.89 11.63 7 123463 16135 63349417
Benign pancreatic neoplasm 13.85 11.63 4 123466 20 63365532
Patella fracture 13.84 11.63 19 123451 2147 63363405
Urticaria 13.78 11.63 233 123237 165569 63199983
Stevens-Johnson syndrome 13.70 11.63 17 123453 24933 63340619
Colostomy infection 13.66 11.63 3 123467 3 63365549
Intestinal ulcer perforation 13.66 11.63 3 123467 3 63365549
Vaccination complication 13.64 11.63 14 123456 1163 63364389
Injection site pruritus 13.64 11.63 141 123329 44975 63320577
Suture related complication 13.62 11.63 7 123463 193 63365359
Adenomyosis 13.62 11.63 10 123460 528 63365024
Spinal osteoarthritis 13.61 11.63 65 123405 16121 63349431
Lipoma 13.58 11.63 20 123450 2411 63363141
Dysphemia 13.51 11.63 21 123449 2654 63362898
Pituitary tumour benign 13.50 11.63 18 123452 1977 63363575
Intervertebral disc compression 13.44 11.63 14 123456 1184 63364368
Paraganglion neoplasm 13.39 11.63 4 123466 23 63365529
Quadriplegia 13.37 11.63 17 123453 1783 63363769
Uterine cyst 13.30 11.63 9 123461 417 63365135
Restlessness 13.30 11.63 23 123447 29430 63336122
Oophorectomy bilateral 13.30 11.63 5 123465 63 63365489
Clavicle fracture 13.28 11.63 24 123446 3431 63362121
Non-small cell lung cancer stage IIIB 13.20 11.63 3 123467 4 63365548
Faeces discoloured 13.19 11.63 10 123460 18499 63347053
Disease progression 13.18 11.63 164 123306 122594 63242958
Injection site vesicles 13.16 11.63 22 123448 2955 63362597
Bone pain 13.16 11.63 58 123412 54583 63310969
Uterine polyp 13.12 11.63 18 123452 2032 63363520
Benign uterine neoplasm 13.10 11.63 4 123466 25 63365527
Invasive lobular breast carcinoma 12.91 11.63 12 123458 883 63364669
Petit mal epilepsy 12.89 11.63 25 123445 3769 63361783
Spinal laminectomy 12.88 11.63 11 123459 724 63364828
Cold type haemolytic anaemia 12.87 11.63 7 123463 217 63365335
Inappropriate antidiuretic hormone secretion 12.87 11.63 7 123463 15455 63350097
Cast application 12.84 11.63 4 123466 27 63365525
Nasal sinus cancer 12.84 11.63 4 123466 27 63365525
Apparent death 12.83 11.63 14 123456 1248 63364304
Gastrointestinal viral infection 12.79 11.63 14 123456 1253 63364299
Pre-eclampsia 12.78 11.63 43 123427 9090 63356462
Crohn's disease 12.75 11.63 29 123441 4884 63360668
Benign neoplasm of bladder 12.72 11.63 4 123466 28 63365524
Lumbar puncture 12.71 11.63 6 123464 137 63365415
Uterine prolapse 12.70 11.63 14 123456 1263 63364289
Thyroid cyst 12.55 11.63 10 123460 597 63364955
Hepatic adenoma 12.54 11.63 8 123462 335 63365217
Arterial therapeutic procedure 12.48 11.63 4 123466 30 63365522
Blood urea increased 12.47 11.63 20 123450 26359 63339193
Breath sounds abnormal 12.46 11.63 3 123467 10970 63354582
Non-small cell lung cancer stage I 12.45 11.63 3 123467 6 63365546
Lhermitte's sign 12.45 11.63 3 123467 6 63365546
Opportunistic infection 12.44 11.63 17 123453 1912 63363640
Female sterilisation 12.43 11.63 10 123460 605 63364947
Cervical incompetence 12.40 11.63 10 123460 607 63364945
Complication of pregnancy 12.36 11.63 10 123460 610 63364942
Appendix disorder 12.33 11.63 15 123455 1504 63364048
Benign neoplasm of thyroid gland 12.32 11.63 13 123457 1116 63364436
Diabetic ketoacidosis 12.31 11.63 13 123457 20492 63345060
Blood pressure decreased 12.28 11.63 75 123395 64947 63300605
Pelvic fracture 12.26 11.63 55 123415 13293 63352259
Progressive relapsing multiple sclerosis 12.25 11.63 4 123466 32 63365520
Gestational hypertension 12.24 11.63 19 123451 2398 63363154
Aspartate aminotransferase abnormal 12.23 11.63 13 123457 1125 63364427
Fatigue 12.23 11.63 1935 121535 886093 62479459
Vulval cancer 12.23 11.63 11 123459 776 63364776
Post procedural swelling 12.19 11.63 8 123462 352 63365200
Eczema 12.19 11.63 28 123442 32263 63333289
Staphylococcal osteomyelitis 12.17 11.63 6 123464 151 63365401
Injection site erosion 12.16 11.63 5 123465 81 63365471
Abdominal adhesions 12.09 11.63 22 123448 3160 63362392
Renal tubular necrosis 12.09 11.63 4 123466 11874 63353678
Pain 12.06 11.63 1259 122211 739369 62626183
Myoclonus 12.06 11.63 8 123462 15860 63349692
Gastric banding 12.05 11.63 5 123465 83 63365469
Eye irritation 12.03 11.63 15 123455 21956 63343596
Toxic skin eruption 12.00 11.63 5 123465 12880 63352672
Hypoalbuminaemia 11.97 11.63 4 123466 11801 63353751
Liver function test increased 11.95 11.63 29 123441 32782 63332770
Lipoma excision 11.94 11.63 4 123466 35 63365517
Haemangioma 11.93 11.63 20 123450 2692 63362860
Therapy partial responder 11.93 11.63 3 123467 10655 63354897
Urinary bladder suspension 11.89 11.63 9 123461 498 63365054
Product complaint 11.88 11.63 5 123465 12804 63352748
Myofascitis 11.85 11.63 3 123467 8 63365544
Accident 11.85 11.63 32 123438 6000 63359552
Narcolepsy 11.83 11.63 14 123456 1364 63364188
Carcinoid tumour of the stomach 11.82 11.63 6 123464 161 63365391
Hepatocellular injury 11.81 11.63 22 123448 27359 63338193
Dysphonia 11.79 11.63 50 123420 47564 63317988
Uterine haemorrhage 11.79 11.63 25 123445 4016 63361536
Immune system disorder 11.79 11.63 44 123426 9790 63355762
Decreased interest 11.74 11.63 22 123448 3232 63362320
Device dislocation 11.67 11.63 20 123450 25685 63339867
Primary biliary cholangitis 11.67 11.63 13 123457 1186 63364366
Injection site discomfort 11.66 11.63 27 123443 4603 63360949
Pernicious anaemia 11.63 11.63 10 123460 664 63364888

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Multiple sclerosis relapse 3262.12 15.20 941 28630 12192 34915168
Influenza like illness 1448.40 15.20 622 28949 27012 34900348
Gait disturbance 320.64 15.20 377 29194 84763 34842597
General symptom 313.47 15.20 84 29487 800 34926560
Injection site erythema 308.67 15.20 183 29388 15716 34911644
Central nervous system lesion 297.22 15.20 133 29438 6330 34921030
Fall 258.74 15.20 545 29026 202340 34725020
Memory impairment 235.30 15.20 233 29338 43085 34884275
Urinary tract infection 233.42 15.20 320 29251 83761 34843599
Balance disorder 219.55 15.20 218 29353 40436 34886924
Muscle spasticity 199.11 15.20 98 29473 5790 34921570
Injection site pain 193.86 15.20 200 29371 38805 34888555
Hypoaesthesia 192.16 15.20 248 29323 61196 34866164
Mobility decreased 184.18 15.20 173 29398 29955 34897405
Off label use 177.60 15.20 67 29504 419457 34507903
Depression 167.67 15.20 297 29274 96801 34830559
Injection site infection 153.59 15.20 50 29521 976 34926384
Cognitive disorder 138.69 15.20 145 29426 28548 34898812
Toxicity to various agents 137.51 15.20 8 29563 200354 34727006
Acute kidney injury 136.95 15.20 44 29527 304944 34622416
Progressive multiple sclerosis 131.73 15.20 33 29538 234 34927126
Injection site reaction 131.66 15.20 100 29471 12933 34914427
Drug interaction 128.78 15.20 19 29552 225927 34701433
Relapsing-remitting multiple sclerosis 128.64 15.20 44 29527 1006 34926354
Needle fatigue 128.11 15.20 42 29529 839 34926521
Muscular weakness 125.76 15.20 223 29348 72674 34854686
Optic neuritis 125.36 15.20 61 29510 3513 34923847
Gait inability 124.53 15.20 118 29453 20640 34906720
Secondary progressive multiple sclerosis 123.69 15.20 34 29537 359 34927001
Myocardial infarction 122.25 15.20 297 29274 120788 34806572
Injection site cellulitis 119.09 15.20 36 29535 545 34926815
Loss of control of legs 114.93 15.20 37 29534 696 34926664
Gait spastic 111.53 15.20 40 29531 1056 34926304
Diarrhoea 110.20 15.20 101 29470 389811 34537549
Magnetic resonance imaging abnormal 109.10 15.20 44 29527 1612 34925748
Hypertonic bladder 100.76 15.20 43 29528 1821 34925539
Decubitus ulcer 98.02 15.20 72 29499 8849 34918511
Injection site abscess 97.89 15.20 34 29537 815 34926545
Seizure 89.99 15.20 242 29329 104615 34822745
Monoparesis 85.17 15.20 41 29530 2305 34925055
Intervertebral disc protrusion 84.61 15.20 69 29502 9887 34917473
Dyspnoea 84.17 15.20 118 29453 376664 34550696
Anaemia 83.32 15.20 47 29524 233288 34694072
Trigeminal neuralgia 82.16 15.20 33 29538 1196 34926164
Neutropenia 80.93 15.20 17 29554 156761 34770599
Road traffic accident 75.17 15.20 83 29488 17367 34909993
Coronary artery occlusion 72.86 15.20 66 29505 10896 34916464
Ataxia 72.32 15.20 73 29498 13780 34913580
Injection site induration 71.86 15.20 39 29532 2821 34924539
Hypotension 71.73 15.20 50 29521 221599 34705761
Coordination abnormal 71.40 15.20 56 29515 7588 34919772
Cystitis 67.28 15.20 60 29511 9705 34917655
Multiple sclerosis 67.13 15.20 51 29520 6594 34920766
Bladder disorder 61.39 15.20 37 29534 3267 34924093
Micturition urgency 61.37 15.20 48 29523 6477 34920883
Injection site haematoma 61.20 15.20 30 29541 1755 34925605
Thrombocytopenia 59.37 15.20 29 29542 156218 34771142
Musculoskeletal disorder 59.13 15.20 46 29525 6158 34921202
Visual impairment 57.18 15.20 106 29465 35696 34891664
Injection site scar 53.60 15.20 17 29554 304 34927056
Anxiety 53.29 15.20 195 29376 99233 34828127
Injection site necrosis 52.15 15.20 18 29553 423 34926937
Procedural anxiety 52.10 15.20 9 29562 3 34927357
Neurogenic bladder 51.99 15.20 27 29544 1786 34925574
Hyponatraemia 51.83 15.20 5 29566 82686 34844674
Adverse drug reaction 50.82 15.20 90 29481 29252 34898108
Injection site bruising 49.57 15.20 48 29523 8615 34918745
Movement disorder 47.21 15.20 55 29516 12193 34915167
Dysarthria 47.03 15.20 96 29475 34686 34892674
Peroneal nerve palsy 46.55 15.20 30 29541 2981 34924379
Pain 45.80 15.20 313 29258 204362 34722998
Blood creatinine increased 45.61 15.20 12 29559 94964 34832396
Abdominal pain 45.30 15.20 43 29528 163575 34763785
Drug abuse 44.86 15.20 14 29557 99082 34828278
Muscle spasms 44.38 15.20 152 29419 74849 34852511
Drug delivery device placement 44.15 15.20 12 29559 121 34927239
Nausea 43.61 15.20 145 29426 339763 34587597
Interstitial lung disease 43.53 15.20 3 29568 65279 34862081
Chills 42.61 15.20 158 29413 80885 34846475
Renal impairment 41.63 15.20 14 29557 94499 34832861
Hyperkalaemia 41.43 15.20 5 29566 69384 34857976
Product use in unapproved indication 41.39 15.20 24 29547 117475 34809885
Dysstasia 40.85 15.20 51 29520 12144 34915216
Haemoglobin decreased 40.68 15.20 26 29545 120746 34806614
Primary progressive multiple sclerosis 39.84 15.20 9 29562 38 34927322
Product use issue 39.15 15.20 4 29567 63212 34864148
Pancytopenia 38.72 15.20 16 29555 95141 34832219
Platelet count decreased 38.67 15.20 27 29544 119690 34807670
Respiratory failure 38.49 15.20 22 29549 108550 34818810
Rash 38.40 15.20 82 29489 222670 34704690
Amnesia 37.91 15.20 75 29496 26488 34900872
Glioblastoma 36.91 15.20 18 29553 1041 34926319
Bipolar disorder 36.70 15.20 28 29543 3641 34923719
Cerebrovascular accident 36.26 15.20 155 29416 84656 34842704
Injection site haemorrhage 36.21 15.20 43 29528 9725 34917635
Decreased appetite 36.12 15.20 53 29518 166339 34761021
Pleural effusion 36.05 15.20 12 29559 81534 34845826
Speech disorder 36.03 15.20 72 29499 25614 34901746
Lower limb fracture 35.87 15.20 29 29542 4102 34923258
Generalised tonic-clonic seizure 35.45 15.20 64 29507 21110 34906250
Hemiparesis 34.85 15.20 54 29517 15724 34911636
Spinal fusion surgery 34.52 15.20 17 29554 1004 34926356
Head injury 34.45 15.20 58 29513 18102 34909258
Paralysis 33.49 15.20 33 29538 6049 34921311
Blindness unilateral 33.47 15.20 29 29542 4513 34922847
Neutralising antibodies positive 32.74 15.20 9 29562 95 34927265
Prostate cancer 32.43 15.20 90 29481 39559 34887801
Pollakiuria 32.34 15.20 59 29512 19615 34907745
Testicular infarction 32.27 15.20 8 29563 54 34927306
Adverse reaction 32.25 15.20 24 29547 3007 34924353
Asthenia 31.83 15.20 332 29239 244919 34682441
Tachycardia 31.76 15.20 16 29555 84756 34842604
Nocturia 31.51 15.20 41 29530 10169 34917191
Cough 31.44 15.20 49 29522 150091 34777269
Influenza 31.44 15.20 103 29468 49563 34877797
Hypokalaemia 30.65 15.20 6 29565 58208 34869152
Drug specific antibody present 30.53 15.20 24 29547 3261 34924099
Injury associated with device 30.14 15.20 16 29555 1107 34926253
Hypoglycaemia 30.13 15.20 5 29566 54635 34872725
Tremor 30.11 15.20 144 29427 82443 34844917
Concussion 29.84 15.20 21 29550 2412 34924948
Staphylococcal infection 29.44 15.20 77 29494 32683 34894677
Insomnia 28.19 15.20 167 29404 103740 34823620
Agraphia 27.91 15.20 6 29565 19 34927341
Urinary incontinence 27.79 15.20 54 29517 18820 34908540
C-reactive protein increased 27.60 15.20 6 29565 54092 34873268
Hepatic enzyme increased 27.44 15.20 84 29487 38996 34888364
Paraparesis 27.19 15.20 18 29553 1871 34925489
Headache 27.14 15.20 274 29297 200361 34726999
Nephrolithiasis 26.96 15.20 71 29500 30262 34897098
Thyroid cancer 26.62 15.20 17 29554 1663 34925697
Superficial vein prominence 26.44 15.20 5 29566 6 34927354
Progressive relapsing multiple sclerosis 26.44 15.20 5 29566 6 34927354
Multiple organ dysfunction syndrome 26.44 15.20 16 29555 76550 34850810
Muscle tightness 25.97 15.20 26 29545 4858 34922502
Gastrointestinal haemorrhage 25.96 15.20 22 29549 88455 34838905
Ankle fracture 25.78 15.20 24 29547 4101 34923259
Rhabdomyolysis 25.33 15.20 13 29558 68150 34859210
Cardiac failure 25.20 15.20 24 29547 91224 34836136
Post procedural complication 25.18 15.20 39 29532 11349 34916011
Lack of injection site rotation 25.15 15.20 9 29562 236 34927124
Frustration tolerance decreased 24.20 15.20 19 29552 2577 34924783
Ascites 24.10 15.20 5 29566 46566 34880794
Temperature intolerance 23.51 15.20 21 29550 3401 34923959
Neutrophil count decreased 23.51 15.20 7 29564 51097 34876263
Paraesthesia 23.46 15.20 112 29459 64060 34863300
Septic shock 23.45 15.20 16 29555 71818 34855542
Erectile dysfunction 23.34 15.20 53 29518 20584 34906776
COVID-19 23.09 15.20 19 29552 77531 34849829
Injection site atrophy 22.89 15.20 6 29565 52 34927308
Neuropathy peripheral 22.87 15.20 22 29549 83241 34844119
Ophthalmoplegia 22.84 15.20 16 29555 1824 34925536
Diabetes mellitus 22.65 15.20 89 29482 46784 34880576
Hospitalisation 22.45 15.20 10 29561 56892 34870468
Osteonecrosis 22.41 15.20 43 29528 14847 34912513
Suicidal ideation 22.27 15.20 80 29491 40308 34887052
Feeling abnormal 22.13 15.20 109 29462 63126 34864234
Cardiac valve rupture 22.07 15.20 4 29567 3 34927357
Dysgraphia 21.88 15.20 17 29554 2270 34925090
Injection site inflammation 21.63 15.20 12 29559 906 34926454
Chronic lymphocytic leukaemia 21.53 15.20 22 29549 4210 34923150
Rectal haemorrhage 21.50 15.20 4 29567 40245 34887115
Intentional product misuse 21.44 15.20 6 29565 45605 34881755
Intentional product use issue 21.36 15.20 12 29559 59804 34867556
Cardio-respiratory arrest 21.36 15.20 10 29561 55263 34872097
Injection site mass 21.06 15.20 27 29544 6599 34920761
Sensory disturbance 20.95 15.20 26 29545 6151 34921209
Injection site ulcer 20.91 15.20 8 29563 254 34927106
Injection site injury 20.85 15.20 8 29563 256 34927104
Weight increased 20.79 15.20 29 29542 93004 34834356
Pruritus 20.69 15.20 57 29514 141924 34785436
Diplegia 20.66 15.20 12 29559 989 34926371
Neurofibroma 20.64 15.20 4 29567 6 34927354
Hepatic function abnormal 20.55 15.20 6 29565 44357 34883003
Hip arthroplasty 20.49 15.20 22 29549 4457 34922903
Epistaxis 20.35 15.20 12 29559 58239 34869121
Mood swings 20.25 15.20 29 29542 7872 34919488
Feeling cold 20.20 15.20 34 29537 10605 34916755
Overweight 20.18 15.20 15 29556 1875 34925485
Anger 19.99 15.20 36 29535 11848 34915512
Intervertebral disc disorder 19.97 15.20 15 29556 1905 34925455
Productive cough 19.68 15.20 4 29567 37809 34889551
Lactic acidosis 19.58 15.20 3 29568 34769 34892591
Vomiting 19.54 15.20 126 29445 247495 34679865
Stomatitis 19.23 15.20 6 29565 42508 34884852
JC polyomavirus test positive 18.90 15.20 10 29561 687 34926673
Overdose 18.78 15.20 30 29541 91029 34836331
Hernia 18.70 15.20 31 29540 9552 34917808
Glioblastoma multiforme 18.36 15.20 10 29561 728 34926632
Hypoxia 18.35 15.20 12 29559 55083 34872277
Therapeutic product effect incomplete 18.24 15.20 10 29561 50531 34876829
B-cell lymphoma stage I 18.23 15.20 3 29568 0 34927360
Neutralising antibodies 18.23 15.20 3 29568 0 34927360
Fear of injection 18.12 15.20 13 29558 1539 34925821
Urosepsis 18.09 15.20 36 29535 12763 34914597
Injection site irritation 17.92 15.20 12 29559 1271 34926089
Surgery 17.87 15.20 38 29533 14119 34913241
Completed suicide 17.84 15.20 35 29536 98133 34829227
Vein disorder 17.57 15.20 12 29559 1313 34926047
Oxygen saturation decreased 17.55 15.20 12 29559 53806 34873554
Mood altered 17.52 15.20 29 29542 8923 34918437
Blindness 17.52 15.20 39 29532 14947 34912413
Blood creatine phosphokinase increased 17.51 15.20 8 29563 44849 34882511
Vaccination complication 17.03 15.20 5 29566 68 34927292
Scar 17.00 15.20 23 29548 5921 34921439
Injection site pruritus 16.98 15.20 25 29546 6958 34920402
Peripheral swelling 16.96 15.20 24 29547 76517 34850843
Depressed mood 16.94 15.20 45 29526 19272 34908088
Brain neoplasm 16.91 15.20 17 29554 3192 34924168
Pneumonitis 16.79 15.20 4 29567 33874 34893486
Somnolence 16.64 15.20 44 29527 111072 34816288
Vision blurred 16.63 15.20 80 29491 45883 34881477
Oedema 16.58 15.20 9 29562 45732 34881628
Sarcoidosis 16.52 15.20 16 29555 2872 34924488
Back disorder 16.45 15.20 24 29547 6627 34920733
Thrombocytopenic purpura 16.42 15.20 11 29560 1166 34926194
Cholelithiasis 16.30 15.20 47 29524 21101 34906259
Injection site discolouration 16.28 15.20 12 29559 1481 34925879
Blood cholesterol increased 16.17 15.20 46 29525 20497 34906863
Anal incontinence 16.14 15.20 26 29545 7823 34919537
Procedural pain 15.93 15.20 20 29551 4786 34922574
Umbilical cord around neck 15.76 15.20 6 29565 188 34927172
Appendicitis perforated 15.74 15.20 13 29558 1895 34925465
Diplopia 15.55 15.20 40 29531 16803 34910557
General physical health deterioration 15.51 15.20 56 29515 128213 34799147
Therapeutic response decreased 15.47 15.20 3 29568 29310 34898050
Injection site dryness 15.22 15.20 4 29567 35 34927325
Wheezing 15.22 15.20 8 29563 41394 34885966

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Multiple sclerosis relapse 8676.84 11.57 2984 103317 43549 79594538
Influenza like illness 4271.13 11.57 2025 104276 69682 79568405
Fall 1019.11 11.57 2097 104204 485532 79152555
Gait disturbance 757.43 11.57 1142 105159 206364 79431723
Off label use 747.40 11.57 152 106149 907063 78731024
General symptom 719.15 11.57 224 106077 2310 79635777
Breast cancer 704.19 11.57 481 105820 33300 79604787
Central nervous system lesion 576.57 11.57 304 105997 13064 79625023
Urinary tract infection 549.57 11.57 1162 105139 273350 79364737
Balance disorder 523.55 11.57 652 105649 98205 79539882
Optic neuritis 508.11 11.57 250 106051 9270 79628817
Injection site pain 488.03 11.57 725 105576 129113 79508974
Depression 477.63 11.57 955 105346 215835 79422252
Memory impairment 474.19 11.57 661 105640 111073 79527014
Injection site erythema 464.96 11.57 547 105754 77650 79560437
Hypoaesthesia 446.27 11.57 832 105469 178520 79459567
Toxicity to various agents 436.69 11.57 33 106268 421507 79216580
Seizure 384.00 11.57 805 105496 188029 79450058
Loss of control of legs 380.29 11.57 130 106171 1835 79636252
Intervertebral disc protrusion 361.45 11.57 279 106022 23342 79614745
Drug interaction 331.64 11.57 74 106227 415109 79222978
Diarrhoea 313.55 11.57 431 105870 880058 78758029
Acute kidney injury 311.29 11.57 152 106149 519252 79118835
Gait inability 298.07 11.57 380 105921 58537 79579550
Muscular weakness 292.11 11.57 655 105646 160074 79478013
Muscle spasticity 290.67 11.57 236 106065 21239 79616848
Secondary progressive multiple sclerosis 288.34 11.57 97 106204 1300 79636787
Magnetic resonance imaging abnormal 269.26 11.57 118 106183 3341 79634746
Injection site bruising 267.46 11.57 301 106000 40701 79597386
Febrile neutropenia 257.40 11.57 12 106289 230987 79407100
Decubitus ulcer 254.75 11.57 192 106109 15495 79622592
Uterine leiomyoma 240.07 11.57 133 106168 6310 79631777
Myocardial infarction 233.17 11.57 654 105647 183475 79454612
Product use in unapproved indication 231.89 11.57 30 106271 250329 79387758
Product use issue 227.14 11.57 13 106288 209809 79428278
Injection site haemorrhage 222.99 11.57 228 106073 27642 79610445
Dyspnoea 222.20 11.57 511 105790 856514 78781573
Hysterectomy 216.13 11.57 123 106178 6149 79631938
Neutropenia 214.58 11.57 59 106242 287651 79350436
Ankle fracture 214.01 11.57 179 106122 16790 79621297
Rash 213.64 11.57 275 106026 578083 79060004
Stress 209.91 11.57 379 105922 79233 79558854
Trigeminal neuralgia 205.25 11.57 99 106202 3510 79634577
Injection site infection 200.34 11.57 84 106217 2128 79635959
Coronary artery occlusion 200.31 11.57 165 106136 15150 79622937
Drug ineffective 200.17 11.57 755 105546 1080158 78557929
Injection site reaction 199.98 11.57 302 105999 54483 79583604
Injection site cellulitis 194.21 11.57 76 106225 1602 79636485
Abortion spontaneous 189.67 11.57 215 106086 29292 79608795
Contraindicated product administered 186.51 11.57 5 106296 157533 79480554
Progressive multiple sclerosis 183.94 11.57 67 106234 1150 79636937
Synovitis 181.45 11.57 4 106297 150730 79487357
Road traffic accident 180.10 11.57 255 106046 43409 79594678
Musculoskeletal disorder 172.56 11.57 176 106125 21272 79616815
Breast cancer female 172.32 11.57 134 106167 11327 79626760
Injection site abscess 171.39 11.57 69 106232 1571 79636516
Completed suicide 171.28 11.57 57 106244 245710 79392377
Relapsing-remitting multiple sclerosis 166.00 11.57 66 106235 1453 79636634
Mobility decreased 160.53 11.57 440 105861 121735 79516352
Therapeutic product effect incomplete 158.91 11.57 7 106294 141638 79496449
Hypotension 158.71 11.57 213 106088 440104 79197983
Cerebrovascular accident 158.19 11.57 511 105790 154781 79483306
Infusion related reaction 155.94 11.57 56 106245 230181 79407906
Malignant neoplasm progression 154.97 11.57 6 106295 135984 79502103
Drug abuse 154.26 11.57 18 106283 162673 79475414
Muscle spasms 154.25 11.57 548 105753 174182 79463905
Coordination abnormal 152.05 11.57 149 106152 17163 79620924
Chills 150.51 11.57 513 105788 159721 79478366
Abdominal pain 148.07 11.57 181 106120 389388 79248699
Urinary incontinence 145.73 11.57 223 106078 40686 79597401
Bladder disorder 144.00 11.57 110 106191 9055 79629032
Hip fracture 142.44 11.57 190 106111 30571 79607516
Pancytopenia 141.65 11.57 25 106276 165720 79472367
Injection site haematoma 138.27 11.57 84 106217 4743 79633344
Peroneal nerve palsy 137.73 11.57 91 106210 5951 79632136
Cystitis 136.37 11.57 249 106052 52483 79585604
Hyponatraemia 135.31 11.57 35 106266 177813 79460274
Rheumatoid arthritis 134.03 11.57 55 106246 208415 79429672
Injection site necrosis 133.43 11.57 56 106245 1422 79636665
Joint swelling 132.44 11.57 114 106187 288532 79349555
Thyroid cancer 131.86 11.57 86 106215 5502 79632585
Stomatitis 130.17 11.57 20 106281 146737 79491350
Caesarean section 129.41 11.57 118 106183 12417 79625670
Post procedural complication 128.92 11.57 159 106142 23670 79614417
Cognitive disorder 128.02 11.57 286 106015 69640 79568447
Multiple sclerosis 127.57 11.57 153 106148 22129 79615958
Hyperkalaemia 124.03 11.57 7 106294 114391 79523696
Intentional product use issue 123.51 11.57 26 106275 152086 79486001
Head injury 121.03 11.57 195 106106 37174 79600913
Blood creatinine increased 120.89 11.57 29 106272 155028 79483059
C-reactive protein increased 120.52 11.57 15 106286 129012 79509075
Lower limb fracture 117.77 11.57 150 106151 23065 79615022
Nausea 117.26 11.57 772 105529 956424 78681663
Breast cancer in situ 117.13 11.57 45 106256 901 79637186
Anaemia 116.81 11.57 263 106038 444752 79193335
Neurogenic bladder 114.78 11.57 71 106230 4141 79633946
Upper limb fracture 110.54 11.57 128 106173 17839 79620248
Thrombocytopenia 109.69 11.57 115 106186 265144 79372943
Cough 109.65 11.57 201 106100 366588 79271499
Needle fatigue 108.45 11.57 42 106259 860 79637227
Injection site scar 108.08 11.57 41 106260 792 79637295
Peripheral swelling 106.95 11.57 121 106180 269496 79368591
General physical health deterioration 106.50 11.57 126 106175 275112 79362975
Glossodynia 101.60 11.57 10 106291 103327 79534760
Dysstasia 101.29 11.57 153 106148 27593 79610494
Gait spastic 100.24 11.57 43 106258 1154 79636933
Drug hypersensitivity 98.34 11.57 154 106147 298762 79339325
Diabetes mellitus 97.68 11.57 277 106024 78113 79559974
Pruritus 97.32 11.57 241 106060 394407 79243680
Decreased appetite 96.79 11.57 194 106107 342224 79295863
Visual impairment 95.41 11.57 305 105996 91826 79546261
Therapeutic product effect decreased 94.84 11.57 50 106251 163813 79474274
Interstitial lung disease 94.00 11.57 18 106283 112582 79525505
Tremor 93.14 11.57 461 105840 169622 79468465
Asthenia 92.76 11.57 1066 105235 510623 79127464
Cholelithiasis 91.50 11.57 211 106090 52453 79585634
Electrocardiogram QT prolonged 90.85 11.57 8 106293 90378 79547709
Amnesia 90.77 11.57 235 106066 62822 79575265
Nephrolithiasis 89.83 11.57 211 106090 53080 79585007
Invasive ductal breast carcinoma 88.81 11.57 69 106232 5823 79632264
Hemiparesis 88.11 11.57 160 106141 33573 79604514
Abdominal discomfort 87.48 11.57 124 106177 250603 79387484
Treatment failure 86.16 11.57 61 106240 170425 79467662
Adverse drug reaction 85.06 11.57 237 106064 66155 79571932
Micturition urgency 84.46 11.57 94 106207 12547 79625540
Malignant melanoma 84.02 11.57 101 106200 14640 79623447
Intracranial aneurysm 83.59 11.57 60 106241 4490 79633597
Ovarian cancer 81.88 11.57 56 106245 3878 79634209
Lower respiratory tract infection 81.57 11.57 35 106266 129185 79508902
Renal impairment 80.34 11.57 56 106245 157727 79480360
Anxiety 79.82 11.57 586 105715 247926 79390161
Hypokalaemia 78.96 11.57 47 106254 143993 79494094
Staphylococcal infection 78.56 11.57 212 106089 58083 79580004
Haemoglobin decreased 78.33 11.57 109 106192 222010 79416077
Psoriatic arthropathy 78.13 11.57 7 106294 77992 79560095
Mucosal inflammation 77.87 11.57 6 106295 75574 79562513
Blindness unilateral 76.98 11.57 73 106228 8073 79630014
Injection site mass 76.10 11.57 113 106188 20071 79618016
Metabolic acidosis 76.08 11.57 10 106291 82519 79555568
Migraine 75.92 11.57 273 106028 87220 79550867
Pericarditis 74.64 11.57 23 106278 104213 79533874
Injection site induration 74.33 11.57 78 106223 9741 79628346
Drug delivery device placement 74.09 11.57 22 106279 190 79637897
Multiple organ dysfunction syndrome 73.64 11.57 34 106267 120212 79517875
Hypoglycaemia 73.51 11.57 22 106279 101572 79536515
Oedema 72.94 11.57 34 106267 119546 79518541
Neuromyelitis optica spectrum disorder 72.94 11.57 33 106268 1009 79637078
Dyspnoea exertional 72.51 11.57 14 106287 87059 79551028
Kidney infection 72.09 11.57 115 106186 21736 79616351
Pleural effusion 72.06 11.57 53 106248 145209 79492878
Intentional product misuse 71.84 11.57 19 106282 95146 79542941
Wheezing 71.43 11.57 33 106268 116631 79521456
Tachycardia 71.31 11.57 79 106222 177689 79460398
Platelet count decreased 71.19 11.57 93 106208 194571 79443516
Sensory disturbance 71.14 11.57 94 106207 14983 79623104
Oxygen saturation decreased 70.88 11.57 42 106259 129005 79509082
Gastrointestinal haemorrhage 69.34 11.57 57 106244 147662 79490425
Gastric bypass 68.92 11.57 34 106267 1267 79636820
Lactic acidosis 68.66 11.57 7 106294 70352 79567735
Paraesthesia 68.63 11.57 436 105865 175887 79462200
Neutrophil count decreased 68.61 11.57 20 106281 93939 79544148
Melaena 68.30 11.57 3 106298 60887 79577200
Concussion 67.54 11.57 73 106228 9430 79628657
Generalised tonic-clonic seizure 66.67 11.57 167 106134 43743 79594344
Loss of personal independence in daily activities 66.00 11.57 27 106274 102553 79535534
Ataxia 65.69 11.57 119 106182 24920 79613167
Speech disorder 65.49 11.57 190 106111 54255 79583832
Procedural pain 64.79 11.57 113 106188 22971 79615116
COVID-19 64.42 11.57 69 106232 157605 79480482
Injury associated with device 63.87 11.57 46 106255 3460 79634627
Intentional overdose 63.29 11.57 31 106270 105929 79532158
Hypertension 63.23 11.57 697 105604 330295 79307792
Lumbar spinal stenosis 63.06 11.57 54 106247 5228 79632859
Helicobacter infection 62.94 11.57 9 106292 69695 79568392
Endometriosis 62.01 11.57 46 106255 3622 79634465
International normalised ratio increased 61.92 11.57 18 106283 84703 79553384
Intervertebral disc disorder 61.04 11.57 51 106250 4774 79633313
Respiratory failure 60.61 11.57 92 106209 180819 79457268
Intervertebral disc degeneration 60.41 11.57 89 106212 15696 79622391
Scar 60.07 11.57 87 106214 15109 79622978
Appendicitis perforated 59.99 11.57 43 106258 3210 79634877
Therapeutic response decreased 59.51 11.57 9 106292 66844 79571243
Procedural anxiety 59.19 11.57 26 106275 740 79637347
Hypertonic bladder 58.60 11.57 47 106254 4154 79633933
Arthralgia 58.32 11.57 485 105816 571318 79066769
Bipolar disorder 57.95 11.57 61 106240 7646 79630441
Drug specific antibody present 57.94 11.57 57 106244 6595 79631492
Cardiac failure 57.62 11.57 73 106228 154769 79483318
Spinal stenosis 57.53 11.57 87 106214 15704 79622383
Injection site ulcer 57.49 11.57 25 106276 694 79637393
Headache 56.50 11.57 1202 105099 652570 78985517
Paraparesis 56.16 11.57 44 106257 3759 79634328
Temperature intolerance 56.14 11.57 67 106234 9638 79628449
Rhabdomyolysis 56.03 11.57 34 106267 103097 79534990
Cardio-respiratory arrest 55.91 11.57 38 106263 108472 79529615
Breast cancer stage I 55.75 11.57 56 106245 6644 79631443
Productive cough 55.62 11.57 24 106277 88307 79549780
Cervical spinal stenosis 54.91 11.57 36 106265 2323 79635764
Hypoxia 54.75 11.57 35 106266 103208 79534879
Influenza 54.51 11.57 327 105974 129279 79508808
Feeling abnormal 54.31 11.57 381 105920 158818 79479269
Thrombosis 54.11 11.57 239 106062 83861 79554226
Overdose 54.04 11.57 102 106199 184104 79453983
Lung neoplasm malignant 53.48 11.57 116 106185 27676 79610411
Blood pressure systolic increased 53.24 11.57 12 106289 66974 79571113
Intraductal proliferative breast lesion 53.13 11.57 36 106265 2455 79635632
Monoparesis 52.67 11.57 41 106260 3470 79634617
Blister 52.56 11.57 49 106252 119427 79518660
Vomiting 52.24 11.57 602 105699 665226 78972861
Injection site atrophy 52.03 11.57 20 106281 401 79637686
Ligament rupture 51.71 11.57 40 106261 3354 79634733
Meningioma benign 51.46 11.57 18 106283 273 79637814
Paralysis 51.45 11.57 75 106226 13102 79624985
Hypocalcaemia 51.32 11.57 4 106297 49920 79588167
Surgery 51.20 11.57 126 106175 32640 79605447
Psoriasis 50.85 11.57 28 106273 89559 79548528
Tibia fracture 50.58 11.57 48 106253 5313 79632774
Hypomagnesaemia 50.44 11.57 3 106298 46908 79591179
Hospitalisation 49.90 11.57 32 106269 94204 79543883
Septic shock 49.87 11.57 54 106247 122747 79515340
Dysgraphia 49.73 11.57 42 106259 3990 79634097
Folliculitis 48.07 11.57 8 106293 55372 79582715
Postoperative wound infection 48.06 11.57 72 106229 12889 79625198
Disease progression 47.42 11.57 110 106191 184252 79453835
Gallbladder disorder 47.07 11.57 89 106212 19251 79618836
Ascites 46.83 11.57 21 106280 75541 79562546
Cervix carcinoma 46.72 11.57 32 106269 2221 79635866
Blood creatine phosphokinase increased 46.57 11.57 15 106286 66075 79572012
Pain in extremity 46.16 11.57 712 105589 363826 79274261
Basedow's disease 45.78 11.57 16 106285 242 79637845
Nerve compression 45.76 11.57 59 106242 9180 79628907
Maternal exposure timing unspecified 45.62 11.57 47 106254 5745 79632342
Cellulitis 45.11 11.57 274 106027 108786 79529301
Haematochezia 44.74 11.57 31 106270 87614 79550473
Systemic lupus erythematosus 44.15 11.57 58 106243 121091 79516996
Dysarthria 44.12 11.57 193 106108 67429 79570658
Neutralising antibodies positive 43.90 11.57 16 106285 275 79637812
Injection site irritation 43.73 11.57 38 106263 3752 79634335
Fatigue 43.59 11.57 1580 104721 928147 78709940
Nasal congestion 43.34 11.57 24 106277 76528 79561559
Feeling cold 43.33 11.57 109 106192 28620 79609467
Depressed level of consciousness 43.27 11.57 39 106262 96613 79541474
Vision blurred 43.14 11.57 265 106036 105633 79532454
Meniscus injury 42.95 11.57 49 106252 6719 79631368
Pulmonary thrombosis 42.84 11.57 66 106235 12105 79625982
Papillary thyroid cancer 42.75 11.57 32 106269 2554 79635533
Pregnancy 42.75 11.57 104 106197 26747 79611340
Fibula fracture 42.72 11.57 37 106264 3637 79634450
Muscle tightness 42.64 11.57 68 106233 12846 79625241
Serotonin syndrome 42.61 11.57 5 106296 45022 79593065
Foot fracture 42.58 11.57 92 106209 21889 79616198
Neuropathy peripheral 42.54 11.57 77 106224 141228 79496859
Muscle injury 42.18 11.57 7 106294 48554 79589533
Swelling 41.99 11.57 148 106153 216563 79421524
Cholecystectomy 41.74 11.57 57 106244 9375 79628712
Diplopia 41.42 11.57 118 106183 33348 79604739
Somnolence 41.28 11.57 171 106130 238810 79399277
Medication error 41.11 11.57 20 106281 68622 79569465
Back disorder 41.06 11.57 63 106238 11515 79626572
Constipation 40.95 11.57 216 106085 282834 79355253
Pollakiuria 40.87 11.57 126 106175 37191 79600896
Rash maculo-papular 40.82 11.57 12 106289 56066 79582021
Primary progressive multiple sclerosis 40.69 11.57 12 106289 101 79637986
Lack of injection site rotation 40.35 11.57 18 106283 532 79637555
Drug intolerance 40.22 11.57 198 106103 263921 79374166
Injection site scab 40.21 11.57 16 106285 353 79637734
Injection site inflammation 40.20 11.57 37 106264 3939 79634148
Focal dyscognitive seizures 40.10 11.57 35 106266 3477 79634610
Drug dependence 39.92 11.57 4 106297 40765 79597322
Sedation 39.85 11.57 10 106291 51885 79586202
Cytomegalovirus infection 39.70 11.57 5 106296 42639 79595448
Movement disorder 39.64 11.57 102 106199 27157 79610930
Ovarian cyst 39.56 11.57 65 106236 12590 79625497
Mammoplasty 39.48 11.57 15 106286 291 79637796
Knee arthroplasty 39.27 11.57 137 106164 43111 79594976
Pneumonitis 39.17 11.57 16 106285 60844 79577243
Appendicitis 39.11 11.57 86 106215 20708 79617379
Erythema 39.05 11.57 159 106142 223131 79414956
Haemorrhage in pregnancy 38.95 11.57 24 106277 1390 79636697
Agraphia 38.88 11.57 10 106291 47 79638040
Breast cancer recurrent 38.77 11.57 32 106269 2945 79635142
Upper gastrointestinal haemorrhage 38.17 11.57 5 106296 41375 79596712
Bradycardia 38.07 11.57 77 106224 135480 79502607
Burning sensation 37.99 11.57 167 106134 58465 79579622
Glioblastoma 37.83 11.57 25 106276 1635 79636452
Meningioma 37.75 11.57 37 106264 4261 79633826
Wound infection staphylococcal 37.24 11.57 32 106269 3112 79634975
Benign lung neoplasm 37.15 11.57 11 106290 94 79637993
Rotator cuff syndrome 36.99 11.57 67 106234 14028 79624059
Ruptured cerebral aneurysm 36.80 11.57 17 106284 546 79637541
Retinal exudates 36.68 11.57 22 106279 1213 79636874
Urosepsis 36.34 11.57 97 106204 26398 79611689
Agranulocytosis 35.92 11.57 8 106293 45022 79593065
Suicidal ideation 35.60 11.57 198 106103 76142 79561945
Incorrect dose administered 35.42 11.57 30 106271 76600 79561487
Rectal haemorrhage 35.11 11.57 30 106271 76270 79561817
Procedural complication 34.96 11.57 48 106253 7935 79630152
Endometrial cancer 34.82 11.57 26 106275 2068 79636019
Brain neoplasm benign 34.74 11.57 12 106289 175 79637912
Appendicectomy 34.67 11.57 29 106272 2719 79635368
Delirium 34.59 11.57 37 106264 84590 79553497
Thyroid disorder 34.52 11.57 65 106236 14014 79624073
Colon cancer 34.32 11.57 66 106235 14457 79623630
Agitation 34.07 11.57 50 106251 99665 79538422
Spinal disorder 33.84 11.57 54 106247 10206 79627881
Drug ineffective for unapproved indication 33.75 11.57 13 106288 51225 79586862
Bone marrow failure 33.61 11.57 13 106288 51094 79586993
Prolonged labour 33.32 11.57 15 106286 453 79637634
Breech presentation 33.23 11.57 17 106284 685 79637402
Hypervolaemia 33.22 11.57 8 106293 42682 79595405
Thyroid neoplasm 33.08 11.57 30 106271 3134 79634953
Haematuria 32.99 11.57 26 106275 68810 79569277
Uterine cancer 32.84 11.57 32 106269 3659 79634428
Mental impairment 32.76 11.57 76 106225 18960 79619127
Alopecia 32.65 11.57 178 106123 231177 79406910
Facial bones fracture 32.60 11.57 37 106264 5045 79633042
Myelosuppression 32.46 11.57 7 106294 40289 79597798
Tubulointerstitial nephritis 32.14 11.57 6 106295 38229 79599858
Vertigo 32.10 11.57 179 106122 68903 79569184
Colon cancer stage III 31.89 11.57 13 106288 306 79637781
Ligament sprain 31.58 11.57 61 106240 13403 79624684
Band sensation 31.38 11.57 17 106284 771 79637316
Diplegia 31.35 11.57 23 106278 1780 79636307
Phobia 31.13 11.57 14 106287 422 79637665
JC polyomavirus test 31.03 11.57 8 106293 38 79638049
Dry skin 30.96 11.57 27 106274 67968 79570119
Autoimmune hepatitis 30.90 11.57 56 106245 11727 79626360
Accidental exposure to product 30.86 11.57 3 106298 31319 79606768
Shock 30.47 11.57 10 106291 43538 79594549
Injection site nodule 30.36 11.57 31 106270 3749 79634338
Hernia 30.34 11.57 69 106232 16990 79621097
Mouth ulceration 30.26 11.57 7 106294 38387 79599700
Skin laceration 30.07 11.57 96 106205 28866 79609221
Cellulitis staphylococcal 30.02 11.57 19 106282 1154 79636933
Cartilage injury 29.85 11.57 21 106280 1522 79636565
Osteonecrosis 29.53 11.57 100 106201 30995 79607092
Malaise 29.45 11.57 858 105443 489011 79149076
Aphasia 29.44 11.57 132 106169 46600 79591487
Rib fracture 29.35 11.57 93 106208 27854 79610233
Wound 29.32 11.57 70 106231 116109 79521978
Injection site discolouration 29.24 11.57 43 106258 7571 79630516
Rectocele 29.19 11.57 15 106286 610 79637477
Gallbladder operation 29.18 11.57 23 106278 1982 79636105
Product administered at inappropriate site 29.13 11.57 31 106270 3934 79634153
Clostridial infection 29.10 11.57 37 106264 5677 79632410
Epistaxis 29.10 11.57 66 106235 111449 79526638
Eosinophilia 29.06 11.57 12 106289 45333 79592754
Product administration error 29.01 11.57 4 106297 31842 79606245
No adverse event 28.87 11.57 112 106189 37080 79601007
Vein disorder 28.71 11.57 35 106266 5147 79632940
Testicular infarction 28.66 11.57 8 106293 54 79638033
Cholestasis 28.55 11.57 17 106284 52092 79585995
Obstructive airways disorder 28.54 11.57 4 106297 31455 79606632
Breast cancer stage II 28.54 11.57 44 106257 8076 79630011
Blindness 28.49 11.57 93 106208 28290 79609797
Product prescribing error 28.49 11.57 12 106289 44801 79593286
Haemoptysis 28.32 11.57 20 106281 55979 79582108
Inflammation 28.29 11.57 51 106250 93702 79544385
Frustration tolerance decreased 28.28 11.57 42 106259 7460 79630627
Blood potassium decreased 28.27 11.57 130 106171 46382 79591705
Wrist fracture 27.95 11.57 54 106247 11867 79626220
Acute respiratory failure 27.90 11.57 23 106278 59518 79578569
Haemolytic uraemic syndrome 27.87 11.57 32 106269 4417 79633670
Paraplegia 27.78 11.57 34 106267 5019 79633068
Muscle atrophy 27.72 11.57 52 106249 11180 79626907
Hepatic function abnormal 27.67 11.57 34 106267 73073 79565014
Depressed mood 27.64 11.57 133 106168 48347 79589740
Abnormal labour 27.50 11.57 6 106295 11 79638076
Autoimmune thyroiditis 27.46 11.57 31 106270 4202 79633885
Cervical vertebral fracture 27.45 11.57 29 106272 3649 79634438
Benign breast neoplasm 27.29 11.57 16 106285 846 79637241
Arterial occlusive disease 27.20 11.57 44 106257 8412 79629675
Abdominal distension 27.19 11.57 76 106225 119574 79518513
Chronic lymphocytic leukaemia 27.17 11.57 33 106268 4833 79633254
Goitre 26.85 11.57 35 106266 5504 79632583
Spinal fusion surgery 26.81 11.57 34 106267 5204 79632883
Hypercalcaemia 26.59 11.57 9 106292 38421 79599666
Injection site injury 26.50 11.57 15 106286 742 79637345
Central venous catheterisation 26.47 11.57 27 106274 3262 79634825
Dry mouth 26.45 11.57 48 106253 87971 79550116
Loss of consciousness 26.43 11.57 341 105960 167602 79470485
Hip arthroplasty 26.40 11.57 106 106195 35650 79602437
Intervertebral disc operation 25.76 11.57 16 106285 940 79637147
Illness 25.72 11.57 15 106286 46496 79591591
Disseminated intravascular coagulation 25.49 11.57 8 106293 35834 79602253
Rash pruritic 25.37 11.57 35 106266 71594 79566493
Red blood cell sedimentation rate increased 25.15 11.57 15 106286 45927 79592160
Pulmonary sarcoidosis 24.93 11.57 18 106283 1359 79636728
Blood pressure diastolic decreased 24.85 11.57 5 106296 30211 79607876
Oestrogen receptor assay positive 24.85 11.57 11 106290 319 79637768
Brain neoplasm 24.80 11.57 34 106267 5612 79632475
Fractured coccyx 24.78 11.57 16 106285 1006 79637081
Varicose vein 24.73 11.57 30 106271 4389 79633698
Osteoarthritis 24.70 11.57 200 106101 87109 79550978
Epilepsy 24.68 11.57 114 106187 40746 79597341
Blood pressure fluctuation 24.61 11.57 32 106269 67113 79570974
Crohn's disease 24.47 11.57 21 106280 2039 79636048
Volvulus 24.43 11.57 24 106277 2772 79635315
Progesterone receptor assay positive 24.43 11.57 10 106291 238 79637849
Breast calcifications 24.37 11.57 15 106286 867 79637220
Angioedema 24.18 11.57 40 106261 75995 79562092
Decreased immune responsiveness 24.09 11.57 33 106268 5442 79632645
Inappropriate schedule of product administration 24.08 11.57 94 106207 133534 79504553
Post procedural stroke 23.86 11.57 8 106293 106 79637981
Therapy non-responder 23.78 11.57 55 106246 92250 79545837
Abortion missed 23.75 11.57 17 106284 1266 79636821
Coronary artery disease 23.67 11.57 159 106142 65315 79572772
Sarcoidosis 23.65 11.57 41 106260 8294 79629793
Renal cell carcinoma 23.62 11.57 36 106265 6542 79631545
Ophthalmoplegia 23.61 11.57 24 106277 2888 79635199
Cervical dysplasia 23.60 11.57 21 106280 2140 79635947
Orthostatic hypotension 23.58 11.57 24 106277 56140 79581947
Pelvic fracture 23.55 11.57 51 106250 12153 79625934
Oedema peripheral 23.43 11.57 219 106082 252069 79386018
Cholecystitis 23.40 11.57 74 106227 22138 79615949
Anal incontinence 23.40 11.57 65 106236 18103 79619984
Product quality issue 23.39 11.57 8 106293 33932 79604155
Hyperglycaemia 23.32 11.57 36 106265 70299 79567788
Mental disorder 23.28 11.57 93 106208 31209 79606878
Ectopic pregnancy 23.25 11.57 19 106282 1724 79636363
Injection site swelling 23.15 11.57 124 106177 47008 79591079
Pre-eclampsia 23.14 11.57 37 106264 7004 79631083
Panic attack 23.11 11.57 78 106223 24138 79613949
Colostomy closure 22.94 11.57 9 106292 191 79637896
Leukopenia 22.94 11.57 79 106222 116434 79521653
Skull fracture 22.90 11.57 19 106282 1761 79636326
Lung adenocarcinoma 22.73 11.57 39 106262 7825 79630262
Thermal burn 22.68 11.57 37 106264 7123 79630964
Bladder dysfunction 22.30 11.57 16 106285 1196 79636891
Fluid retention 21.95 11.57 37 106264 69772 79568315
Atrial fibrillation 21.89 11.57 164 106137 197722 79440365
Spondylolisthesis 21.88 11.57 24 106277 3151 79634936
Dyspepsia 21.87 11.57 73 106228 108614 79529473
Intervertebral disc displacement 21.62 11.57 11 106290 438 79637649
Cephalo-pelvic disproportion 21.51 11.57 8 106293 146 79637941
Anaphylactic reaction 21.49 11.57 50 106251 83693 79554394
Female genital operation 21.45 11.57 5 106296 14 79638073
Urinary tract infection staphylococcal 21.39 11.57 14 106287 901 79637186
Overweight 21.34 11.57 27 106274 4123 79633964
Femur fracture 21.29 11.57 105 106196 38547 79599540
Magnetic resonance imaging head abnormal 21.25 11.57 22 106279 2704 79635383
Incision site complication 21.25 11.57 13 106288 743 79637344
Spinal osteoarthritis 21.25 11.57 60 106241 16867 79621220
Weight increased 21.20 11.57 252 106049 277134 79360953
Ventricular tachycardia 21.18 11.57 15 106286 41920 79596167
Cardiogenic shock 21.16 11.57 15 106286 41899 79596188
Stevens-Johnson syndrome 21.14 11.57 13 106288 39153 79598934
Fear 21.14 11.57 71 106230 21915 79616172
Blood calcium decreased 21.08 11.57 8 106293 31811 79606276
Lumbar radiculopathy 20.99 11.57 19 106282 1980 79636107
Heavy menstrual bleeding 20.96 11.57 53 106248 13958 79624129
Withdrawal syndrome 20.96 11.57 5 106296 26849 79611238
Ovarian germ cell teratoma benign 20.95 11.57 6 106295 45 79638042
Renal tubular necrosis 20.90 11.57 4 106297 25035 79613052
Demyelination 20.88 11.57 38 106263 7985 79630102
Chronic kidney disease 20.86 11.57 35 106266 66119 79571968
Enterocele 20.83 11.57 6 106295 46 79638041
Post procedural haemorrhage 20.57 11.57 52 106249 13692 79624395
Ovarian cancer stage III 20.43 11.57 9 106292 258 79637829
JC polyomavirus test positive 20.40 11.57 17 106284 1585 79636502
Retinal tear 20.40 11.57 17 106284 1585 79636502
Oral candidiasis 20.39 11.57 7 106294 29621 79608466
Hepatotoxicity 20.38 11.57 23 106278 51329 79586758
Blood urea increased 20.31 11.57 21 106280 48769 79589318
Benign neoplasm of spinal cord 20.25 11.57 4 106297 3 79638084
Expanded disability status scale score increased 20.22 11.57 12 106289 649 79637438
Malignant hypertension 20.22 11.57 17 106284 1605 79636482
Clavicle fracture 20.18 11.57 27 106274 4354 79633733
Conversion disorder 20.15 11.57 18 106283 1843 79636244
Arthritis 20.11 11.57 238 106063 114642 79523445
Atrophy 20.08 11.57 19 106282 2095 79635992
Fibrocystic breast disease 20.07 11.57 12 106289 658 79637429
Myoclonus 19.98 11.57 6 106295 27654 79610433
Rectal cancer 19.90 11.57 24 106277 3489 79634598
Glioblastoma multiforme 19.87 11.57 15 106286 1213 79636874
Prescribed overdose 19.86 11.57 13 106288 37870 79600217
Polyneuropathy 19.86 11.57 4 106297 24147 79613940
Bronchopulmonary aspergillosis 19.84 11.57 3 106298 22291 79615796
Raynaud's phenomenon 19.79 11.57 14 106287 1024 79637063
Tachypnoea 19.73 11.57 9 106292 32054 79606033
Cholecystitis infective 19.70 11.57 22 106279 2947 79635140
Fat necrosis 19.67 11.57 13 106288 850 79637237
Patella fracture 19.66 11.57 18 106283 1903 79636184
Insomnia 19.55 11.57 446 105855 244724 79393363
Vaccination complication 19.54 11.57 13 106288 860 79637227
Endometrial cancer stage I 19.52 11.57 8 106293 191 79637896
Accident 19.49 11.57 39 106262 8792 79629295
Limb mass 19.44 11.57 24 106277 3575 79634512
Restlessness 19.36 11.57 20 106281 46472 79591615
Cardiac arrest 19.33 11.57 142 106159 171954 79466133
Neuralgia 19.33 11.57 92 106209 33292 79604795
Medical induction of coma 19.28 11.57 7 106294 119 79637968
Motor dysfunction 19.26 11.57 53 106248 14680 79623407
Post procedural infection 19.10 11.57 45 106256 11339 79626748
Right ventricular failure 19.09 11.57 4 106297 23493 79614594
Oropharyngeal pain 19.02 11.57 78 106223 109275 79528812
Schwannoma 19.01 11.57 7 106294 124 79637963
Nerve injury 18.99 11.57 40 106261 9352 79628735
Scoliosis 18.98 11.57 35 106266 7429 79630658
Throat irritation 18.96 11.57 16 106285 40930 79597157
Liver function test abnormal 18.95 11.57 149 106152 64326 79573761
Fear of injection 18.94 11.57 35 106266 7439 79630648
Feeling of body temperature change 18.91 11.57 29 106272 5297 79632790
Urinary bladder suspension 18.86 11.57 7 106294 127 79637960
Cardiac valve rupture 18.83 11.57 4 106297 6 79638081
Rectal cancer stage I 18.83 11.57 4 106297 6 79638081
Poor venous access 18.70 11.57 60 106241 18089 79619998
Irritable bowel syndrome 18.65 11.57 34 106267 62207 79575880
Injection site calcification 18.56 11.57 5 106296 29 79638058
Carotid artery aneurysm 18.43 11.57 9 106292 328 79637759
Limb injury 18.29 11.57 83 106218 29445 79608642
Gun shot wound 18.29 11.57 14 106287 1156 79636931
Injection site thrombosis 18.27 11.57 7 106294 139 79637948
Back injury 18.09 11.57 42 106259 10481 79627606
Arthropathy 18.09 11.57 150 106151 176961 79461126
Ventricular fibrillation 18.08 11.57 10 106291 31916 79606171
Haematemesis 18.05 11.57 26 106275 52238 79585849
Reaction to preservatives 17.98 11.57 8 106293 235 79637852
Oral pain 17.95 11.57 10 106291 31788 79606299
Precancerous cells present 17.90 11.57 14 106287 1193 79636894
Breast cancer metastatic 17.81 11.57 37 106264 8565 79629522
Colon cancer metastatic 17.73 11.57 18 106283 2163 79635924
Bladder prolapse 17.70 11.57 15 106286 1432 79636655
Lung adenocarcinoma stage I 17.64 11.57 5 106296 36 79638051
Skin graft 17.63 11.57 13 106288 1014 79637073
Crying 17.57 11.57 69 106232 22974 79615113
Uterine disorder 17.55 11.57 18 106283 2189 79635898
Rhinorrhoea 17.52 11.57 48 106253 76026 79562061
Adrenal insufficiency 17.52 11.57 8 106293 28479 79609608
Heat stroke 17.52 11.57 16 106285 1687 79636400
Skin exfoliation 17.51 11.57 29 106272 55071 79583016
Injection site fibrosis 17.49 11.57 4 106297 10 79638077
Full blood count decreased 17.34 11.57 7 106294 26812 79611275
Foetal heart rate abnormal 17.31 11.57 9 106292 375 79637712
Progressive relapsing multiple sclerosis 17.29 11.57 5 106296 39 79638048
Pulmonary oedema 17.26 11.57 60 106241 88194 79549893
Female sterilisation 17.26 11.57 8 106293 259 79637828
Lipoatrophy 17.23 11.57 11 106290 678 79637409
Optic nerve disorder 17.20 11.57 14 106287 1263 79636824
Haemophagocytic lymphohistiocytosis 17.17 11.57 4 106297 21833 79616254
Arthroscopy 17.14 11.57 10 106291 524 79637563
Rales 17.11 11.57 3 106298 19998 79618089
Endometrial adenocarcinoma 17.10 11.57 13 106288 1062 79637025
Emotional disorder 17.10 11.57 50 106251 14337 79623750
Lung disorder 16.97 11.57 53 106248 80504 79557583
Anaesthetic complication 16.97 11.57 20 106281 2839 79635248
Non-small cell lung cancer stage I 16.96 11.57 4 106297 12 79638075
Uterine leiomyosarcoma 16.96 11.57 4 106297 12 79638075
Invasive lobular breast carcinoma 16.92 11.57 11 106290 700 79637387
Visual acuity reduced 16.91 11.57 81 106220 29388 79608699
Alpha-1 anti-trypsin increased 16.87 11.57 3 106298 0 79638087
Neurological complication associated with device 16.87 11.57 3 106298 0 79638087
Biopsy bladder 16.87 11.57 3 106298 0 79638087
Benign uterine neoplasm 16.87 11.57 3 106298 0 79638087
Gastric cyst 16.86 11.57 6 106295 96 79637991
Knee operation 16.83 11.57 29 106272 5837 79632250
Inappropriate antidiuretic hormone secretion 16.80 11.57 7 106294 26306 79611781
Encephalopathy 16.69 11.57 41 106260 67356 79570731
Intervertebral disc injury 16.60 11.57 7 106294 180 79637907
Eczema 16.51 11.57 18 106283 40800 79597287
Amniotic fluid volume decreased 16.47 11.57 8 106293 288 79637799
Discomfort 16.44 11.57 99 106202 125518 79512569
Calculus bladder 16.32 11.57 14 106287 1358 79636729
Febrile convulsion 16.30 11.57 12 106289 934 79637153
Incision site abscess 16.20 11.57 9 106292 429 79637658
Urinary retention postoperative 16.18 11.57 7 106294 192 79637895
Complication of delivery 16.16 11.57 6 106295 109 79637978
Hallucination, visual 16.14 11.57 12 106289 32717 79605370
Hepatocellular injury 16.12 11.57 24 106277 47569 79590518
Abdominal pain upper 16.09 11.57 206 106095 223613 79414474
Rash erythematous 16.05 11.57 33 106268 57736 79580351
Reproductive tract disorder 16.01 11.57 5 106296 52 79638035
Cast application 15.88 11.57 4 106297 17 79638070
Toxic skin eruption 15.81 11.57 5 106296 22288 79615799
Skin cancer 15.75 11.57 50 106251 14990 79623097
Nocturia 15.74 11.57 47 106254 13634 79624453
Serum serotonin decreased 15.69 11.57 4 106297 18 79638069
Frequent bowel movements 15.67 11.57 10 106291 29529 79608558
Incontinence 15.67 11.57 48 106253 14116 79623971
Cardiac disorder 15.65 11.57 145 106156 65612 79572475
Hand fracture 15.59 11.57 29 106272 6196 79631891
Liver function test increased 15.58 11.57 18 106283 39755 79598332
Meningitis viral 15.42 11.57 16 106285 1972 79636115
Product substitution issue 15.37 11.57 4 106297 20252 79617835
Spinal fracture 15.37 11.57 56 106245 17998 79620089
Heat exhaustion 15.22 11.57 8 106293 341 79637746
Neurofibroma 15.18 11.57 4 106297 21 79638066
Pulmonary fibrosis 15.18 11.57 22 106279 44090 79593997
Uterine mass 15.03 11.57 7 106294 229 79637858
Altered state of consciousness 14.94 11.57 22 106279 43800 79594287
Pain in jaw 14.94 11.57 24 106277 46127 79591960
Relapsing multiple sclerosis 14.93 11.57 6 106295 136 79637951
Umbilical cord around neck 14.88 11.57 4 106297 23 79638064
Dystonia 14.82 11.57 5 106296 21394 79616693
Hyperthermia 14.80 11.57 3 106298 18034 79620053
Cystitis pseudomonal 14.79 11.57 3 106298 3 79638084
Lhermitte's sign 14.79 11.57 3 106298 3 79638084
Ovarian adenoma 14.78 11.57 7 106294 238 79637849
Dysgeusia 14.78 11.57 34 106267 57143 79580944
Medical device removal 14.72 11.57 10 106291 685 79637402
Hypoalbuminaemia 14.71 11.57 5 106296 21292 79616795
Animal bite 14.69 11.57 18 106283 2661 79635426
Cervical incompetence 14.66 11.57 9 106292 518 79637569
Spinal cord disorder 14.65 11.57 15 106286 1820 79636267
Eye disorder 14.65 11.57 66 106235 23346 79614741
Bone erosion 14.58 11.57 3 106298 17844 79620243
Purpura 14.54 11.57 4 106297 19523 79618564
Cervix carcinoma stage 0 14.52 11.57 7 106294 248 79637839
Hepatic steatosis 14.46 11.57 93 106208 37645 79600442
Facial paralysis 14.40 11.57 61 106240 21011 79617076
Injection site hypoaesthesia 14.39 11.57 9 106292 535 79637552
Ocular hyperaemia 14.36 11.57 10 106291 28196 79609891
Anuria 14.34 11.57 5 106296 20958 79617129
B-cell lymphoma stage I 14.33 11.57 3 106298 4 79638083
Staphylococcal abscess 14.33 11.57 12 106289 1127 79636960
Basal cell carcinoma 14.26 11.57 92 106209 37283 79600804
Contusion 14.24 11.57 278 106023 148498 79489589
Bronchiectasis 14.22 11.57 6 106295 22380 79615707
Dry eye 14.16 11.57 17 106284 36914 79601173
Viral infection 14.10 11.57 102 106199 42914 79595173
Drug eruption 14.08 11.57 23 106278 43912 79594175
Viral pericarditis 14.05 11.57 5 106296 80 79638007
Respiratory distress 14.05 11.57 36 106265 58303 79579784
Porphyria non-acute 14.04 11.57 10 106291 739 79637348
Transaminases increased 14.01 11.57 30 106271 51713 79586374
Optic atrophy 14 11.57 15 106286 1918 79636169
Transient ischaemic attack 13.99 11.57 119 106182 52576 79585511
Superficial vein prominence 13.94 11.57 5 106296 82 79638005
Intracranial hypotension 13.91 11.57 8 106293 408 79637679
Myopathy 13.91 11.57 5 106296 20558 79617529
Premature labour 13.89 11.57 33 106268 8357 79629730
Ovarian cyst ruptured 13.88 11.57 11 106290 955 79637132
Neoplasm malignant 13.84 11.57 81 106220 31729 79606358
Circulatory collapse 13.75 11.57 18 106283 37650 79600437
Nephropathy toxic 13.75 11.57 5 106296 20414 79617673
Neutralising antibodies 13.74 11.57 4 106297 32 79638055
Cystocele 13.72 11.57 10 106291 766 79637321
Eosinophil count increased 13.72 11.57 3 106298 17102 79620985
Confusional state 13.69 11.57 321 105980 317676 79320411
COVID-19 pneumonia 13.69 11.57 11 106290 28838 79609249
Abdominal operation 13.63 11.57 9 106292 588 79637499
Suture rupture 13.55 11.57 9 106292 594 79637493
Uterine haemorrhage 13.54 11.57 18 106283 2885 79635202
Paraganglion neoplasm 13.53 11.57 4 106297 34 79638053
Liposarcoma 13.44 11.57 7 106294 293 79637794
Hyperbilirubinaemia 13.43 11.57 8 106293 24510 79613577
Postoperative thrombosis 13.34 11.57 6 106295 181 79637906
Oophorectomy bilateral 13.32 11.57 4 106297 36 79638051
Benign renal neoplasm 13.32 11.57 4 106297 36 79638051
Ovarian neoplasm 13.30 11.57 9 106292 612 79637475
Sinusitis 13.30 11.57 182 106119 195319 79442768
Non-Hodgkin's lymphoma 13.29 11.57 13 106288 1494 79636593
Limb traumatic amputation 13.23 11.57 4 106297 37 79638050
Hyperaesthesia 13.13 11.57 41 106260 12181 79625906
Arterial therapeutic procedure 13.13 11.57 4 106297 38 79638049
Fasciitis 13.11 11.57 10 106291 821 79637266
Transfusion 13.10 11.57 6 106295 21324 79616763
Spinal laminectomy 13.08 11.57 9 106292 629 79637458
Injury 13.02 11.57 56 106245 77440 79560647
Cerebral thrombosis 13.02 11.57 16 106285 2371 79635716
Face oedema 13.02 11.57 11 106290 28125 79609962
Uterine cyst 13.01 11.57 7 106294 313 79637774
Lyme disease 12.98 11.57 19 106282 3331 79634756
Impaired self-care 12.96 11.57 17 106284 2690 79635397
Lung cancer metastatic 12.94 11.57 20 106281 3679 79634408
Erectile dysfunction 12.92 11.57 46 106255 14618 79623469
Arnold-Chiari malformation 12.86 11.57 6 106295 197 79637890
Gastric banding 12.86 11.57 4 106297 41 79638046
Hemianaesthesia 12.85 11.57 8 106293 472 79637615
Liver injury 12.83 11.57 36 106265 56578 79581509
Bipolar I disorder 12.81 11.57 15 106286 2114 79635973
Sinus bradycardia 12.79 11.57 9 106292 25238 79612849
Clinically isolated syndrome 12.77 11.57 4 106297 42 79638045
Urinary tract disorder 12.76 11.57 20 106281 3722 79634365
Faeces discoloured 12.74 11.57 12 106289 29115 79608972
Intestinal cyst 12.73 11.57 6 106295 202 79637885
Escherichia urinary tract infection 12.72 11.57 44 106257 13781 79624306
Aggression 12.62 11.57 31 106270 50927 79587160
Deafness unilateral 12.59 11.57 21 106280 4117 79633970
Colon cancer stage I 12.49 11.57 5 106296 112 79637975
Thyroid function test abnormal 12.47 11.57 18 106283 3116 79634971
Breath sounds abnormal 12.43 11.57 3 106298 15981 79622106
Aspergillus infection 12.39 11.57 5 106296 19156 79618931
Central nervous system infection 12.37 11.57 12 106289 1365 79636722
Muscle disorder 12.35 11.57 25 106276 5682 79632405
Cystitis interstitial 12.32 11.57 12 106289 1371 79636716
Eye pruritus 12.31 11.57 6 106295 20564 79617523
Simple partial seizures 12.29 11.57 9 106292 695 79637392
Chronic leukaemia 12.26 11.57 3 106298 11 79638076
Complication associated with device 12.23 11.57 51 106250 17445 79620642
Myelitis transverse 12.19 11.57 14 106287 1933 79636154
Aneurysm 12.15 11.57 19 106282 3529 79634558
Haemodynamic instability 12.15 11.57 4 106297 17378 79620709
Cardiac failure acute 12.14 11.57 5 106296 18924 79619163
Drug delivery system malfunction 12.14 11.57 9 106292 708 79637379
Cold type haemolytic anaemia 12.12 11.57 7 106294 360 79637727
Arthritis infective 12.08 11.57 31 106270 8240 79629847
Neurilemmoma benign 12.05 11.57 3 106298 12 79638075
Pallor 11.97 11.57 31 106270 50031 79588056
Allergy to metals 11.92 11.57 8 106293 537 79637550
Complication of pregnancy 11.87 11.57 7 106294 374 79637713
Anti-interferon antibody positive 11.86 11.57 3 106298 13 79638074
Malignant melanoma stage II 11.86 11.57 3 106298 13 79638074
Appendix disorder 11.83 11.57 13 106288 1711 79636376
Retinal detachment 11.83 11.57 33 106268 9214 79628873
Shock haemorrhagic 11.78 11.57 6 106295 20054 79618033
Hepatic encephalopathy 11.74 11.57 9 106292 24157 79613930
Benign neoplasm of bladder 11.73 11.57 4 106297 56 79638031
Placenta praevia 11.72 11.57 9 106292 746 79637341
Tubular breast carcinoma 11.68 11.57 3 106298 14 79638073
Otolithiasis 11.68 11.57 3 106298 14 79638073
Rubber sensitivity 11.67 11.57 13 106288 1736 79636351
Pyelonephritis 11.67 11.57 56 106245 20332 79617755
Lobular breast carcinoma in situ 11.66 11.57 4 106297 57 79638030
Malignant mesenteric neoplasm 11.66 11.57 4 106297 57 79638030
Bacteraemia 11.66 11.57 16 106285 32808 79605279
Sensory loss 11.66 11.57 41 106260 12950 79625137
Breast cellulitis 11.65 11.57 7 106294 387 79637700
Glomerular filtration rate decreased 11.62 11.57 8 106293 22694 79615393
Death of relative 11.59 11.57 6 106295 248 79637839
Thrombotic thrombocytopenic purpura 11.57 11.57 26 106275 6350 79631737

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC L03AB07 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
IMMUNOSTIMULANTS
IMMUNOSTIMULANTS
Interferons
FDA CS M0025715 Interferon-beta
MeSH PA D000276 Adjuvants, Immunologic
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000970 Antineoplastic Agents
MeSH PA D000998 Antiviral Agents
MeSH PA D007155 Immunologic Factors
FDA EPC N0000191625 Interferon beta

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Relapsing remitting multiple sclerosis indication 426373005 DOID:2378




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Interferon alpha/beta receptor Membrane receptor AGONIST DRUG LABEL DRUG LABEL

External reference:

IDSource
XRO4566Q4R UNII
4024025 VANDF
C0254119 UMLSCUI
CHEMBL1201562 ChEMBL_ID
D04554 KEGG_DRUG
DB00060 DRUGBANK_ID
CHEMBL2108510 ChEMBL_ID
D000068556 MESH_DESCRIPTOR_UI
153326 RXNORM
4895 MMSL
6144 MMSL
d04011 MMSL
005910 NDDF
108749003 SNOMEDCT_US
386902004 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
REBIF HUMAN PRESCRIPTION DRUG LABEL 1 44087-0022 INJECTION, SOLUTION 22 ug SUBCUTANEOUS BLA 30 sections
REBIF HUMAN PRESCRIPTION DRUG LABEL 1 44087-0022 INJECTION, SOLUTION 22 ug SUBCUTANEOUS BLA 30 sections
REBIF HUMAN PRESCRIPTION DRUG LABEL 1 44087-0044 INJECTION, SOLUTION 44 ug SUBCUTANEOUS BLA 30 sections
REBIF HUMAN PRESCRIPTION DRUG LABEL 1 44087-0044 INJECTION, SOLUTION 44 ug SUBCUTANEOUS BLA 30 sections
REBIF REBIDOSE HUMAN PRESCRIPTION DRUG LABEL 1 44087-3322 INJECTION, SOLUTION 22 ug SUBCUTANEOUS BLA 30 sections
REBIF REBIDOSE HUMAN PRESCRIPTION DRUG LABEL 1 44087-3322 INJECTION, SOLUTION 22 ug SUBCUTANEOUS BLA 30 sections
REBIF REBIDOSE HUMAN PRESCRIPTION DRUG LABEL 1 44087-3344 INJECTION, SOLUTION 44 ug SUBCUTANEOUS BLA 30 sections
REBIF REBIDOSE HUMAN PRESCRIPTION DRUG LABEL 1 44087-3344 INJECTION, SOLUTION 44 ug SUBCUTANEOUS BLA 30 sections
Avonex HUMAN PRESCRIPTION DRUG LABEL 1 59627-002 INJECTION, SOLUTION 30 ug INTRAMUSCULAR BLA 28 sections
Avonex HUMAN PRESCRIPTION DRUG LABEL 1 59627-002 INJECTION, SOLUTION 30 ug INTRAMUSCULAR BLA 28 sections
Avonex HUMAN PRESCRIPTION DRUG LABEL 1 59627-002 INJECTION, SOLUTION 30 ug INTRAMUSCULAR BLA 28 sections
Avonex Pen HUMAN PRESCRIPTION DRUG LABEL 1 59627-003 INJECTION, SOLUTION 30 ug INTRAMUSCULAR BLA 28 sections
Avonex Pen HUMAN PRESCRIPTION DRUG LABEL 1 59627-003 INJECTION, SOLUTION 30 ug INTRAMUSCULAR BLA 28 sections
Avonex Pen HUMAN PRESCRIPTION DRUG LABEL 1 59627-003 INJECTION, SOLUTION 30 ug INTRAMUSCULAR BLA 28 sections