interferon beta-1a 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	5139	145258-61-3

Description:

Molecule	Description
Synonyms: interferon beta-1a avonex	An interferon beta-1 subtype that has a methionine at position 1, a cysteine at position 17, and is glycosylated at position 80. It functions as an ANTI-VIRAL AGENT and IMMUNOMODULATOR and is used to manage the symptoms of RELAPSING-REMITTING MULTIPLE SCLEROSIS. A possible role for IFNs in prophylaxis or early treatment of COVID-19 has been suggested to compensate for possibly insufficient endogenous IFN production. However, the efficacy and safety of IFNs for treatment or prevention of COVID-19 were not established. Molecular weight: Formula: CLOGP: LIPINSKI: None HAC: None HDO: None TPSA: ALOGS: ROTB: None

Molecule

Description

Synonyms:

interferon beta-1a
avonex

An interferon beta-1 subtype that has a methionine at position 1, a cysteine at position 17, and is glycosylated at position 80. It functions as an ANTI-VIRAL AGENT and IMMUNOMODULATOR and is used to manage the symptoms of RELAPSING-REMITTING MULTIPLE SCLEROSIS. A possible role for IFNs in prophylaxis or early treatment of COVID-19 has been suggested to compensate for possibly insufficient endogenous IFN production. However, the efficacy and safety of IFNs for treatment or prevention of COVID-19 were not established.

Molecular weight:
Formula:
CLOGP:
LIPINSKI: None
HAC: None
HDO: None
TPSA:
ALOGS:
ROTB: None

Drug dosage:

Dose	Unit	Route
4.30	mcg	P

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
May 17, 1996	FDA	BIOGEN

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Multiple sclerosis relapse	8453.14	11.46	3347	117893	39617	50444267
Influenza like illness	4688.34	11.46	2424	118816	55035	50428849
General symptom	880.93	11.46	299	120941	2164	50481720
Fall	825.34	11.46	2196	119044	332736	50151148
Injection site erythema	799.78	11.46	941	120299	73995	50409889
Optic neuritis	772.80	11.46	362	120878	6528	50477356
Off label use	739.94	11.46	125	121115	474301	50009583
Gait disturbance	720.32	11.46	1289	119951	148716	50335168
Central nervous system lesion	702.21	11.46	376	120864	9113	50474771
Breast cancer	692.16	11.46	671	120569	42219	50441665
Injection site pain	669.95	11.46	1057	120183	109967	50373917
Memory impairment	567.35	11.46	818	120422	78542	50405342
Depression	562.23	11.46	1230	120010	164193	50319691
Balance disorder	497.76	11.46	723	120517	69867	50414017
Hypoaesthesia	488.76	11.46	995	120245	126262	50357622
Urinary tract infection	415.36	11.46	1329	119911	222691	50261193
Seizure	406.36	11.46	882	120358	116992	50366892
Diarrhoea	396.04	11.46	499	120741	587977	49895907
Injection site bruising	384.03	11.46	457	120783	36311	50447573
Toxicity to various agents	370.83	11.46	39	121201	212460	50271424
Loss of control of legs	358.17	11.46	130	121110	1171	50482713
Muscular weakness	348.19	11.46	729	120511	94284	50389600
Magnetic resonance imaging abnormal	330.29	11.46	151	121089	2567	50481317
Rash	325.15	11.46	342	120898	437129	50046755
Contraindicated product administered	315.25	11.46	9	121231	148949	50334935
Secondary progressive multiple sclerosis	313.44	11.46	117	121123	1149	50482735
Gait inability	309.83	11.46	412	120828	36615	50447269
Product use issue	305.86	11.46	12	121228	149463	50334421
Injection site haematoma	290.31	11.46	181	121059	5879	50478005
Intervertebral disc protrusion	284.54	11.46	295	120945	20098	50463786
Dyspnoea	283.61	11.46	553	120687	547055	49936829
Drug ineffective	278.94	11.46	1020	120220	818313	49665571
Synovitis	275.88	11.46	4	121236	123861	50360023
Stress	270.08	11.46	472	120768	53321	50430563
Joint swelling	268.52	11.46	126	121114	245160	50238724
Cognitive disorder	261.40	11.46	417	120823	43706	50440178
Infusion related reaction	258.39	11.46	47	121193	169510	50314374
Rheumatoid arthritis	258.15	11.46	82	121158	202468	50281416
Drug interaction	254.08	11.46	81	121159	199540	50284344
Injection site reaction	252.46	11.46	440	120800	49592	50434292
Product use in unapproved indication	248.78	11.46	6	121234	115813	50368071
Breast cancer female	239.01	11.46	168	121072	6694	50477190
Uterine leiomyoma	237.91	11.46	177	121063	7714	50476170
Injection site haemorrhage	222.29	11.46	265	120975	21081	50462803
Glossodynia	218.43	11.46	15	121225	115554	50368330
Completed suicide	213.34	11.46	31	121209	131858	50352026
Injection site scar	212.15	11.46	79	121161	770	50483114
Needle fatigue	207.88	11.46	47	121193	40	50483844
Hysterectomy	207.16	11.46	163	121077	7727	50476157
Decubitus ulcer	206.14	11.46	175	121065	9243	50474641
Abortion spontaneous	205.07	11.46	363	120877	41409	50442475
Abdominal discomfort	204.21	11.46	154	121086	231487	50252397
Neutropenia	203.06	11.46	52	121188	147913	50335971
Acute kidney injury	198.00	11.46	154	121086	227904	50255980
Chills	197.55	11.46	594	120646	96093	50387791
Ankle fracture	195.56	11.46	214	121026	15508	50468376
Injection site necrosis	193.51	11.46	82	121158	1151	50482733
Trigeminal neuralgia	193.47	11.46	110	121130	3005	50480879
Nausea	193.32	11.46	953	120287	704445	49779439
Febrile neutropenia	189.57	11.46	11	121229	97656	50386228
Peripheral swelling	189.21	11.46	131	121109	205805	50278079
Muscle spasticity	181.68	11.46	215	121025	16969	50466915
Drug hypersensitivity	178.57	11.46	203	121037	250807	50233077
Road traffic accident	172.28	11.46	250	120990	24102	50459782
Peroneal nerve palsy	170.80	11.46	114	121126	4169	50479715
Injection site infection	169.40	11.46	82	121158	1594	50482290
Abdominal pain	166.98	11.46	192	121048	236036	50247848
Musculoskeletal disorder	165.41	11.46	206	121034	17143	50466741
Coronary artery occlusion	161.31	11.46	138	121102	7365	50476519
Injection site abscess	158.79	11.46	68	121172	981	50482903
Urinary incontinence	152.68	11.46	256	120984	27952	50455932
Stomatitis	152.37	11.46	29	121211	101315	50382569
Bladder disorder	150.60	11.46	133	121107	7410	50476474
Myocardial infarction	150.00	11.46	512	120728	88515	50395369
Arthralgia	144.60	11.46	552	120688	438150	50045734
Hypotension	144.19	11.46	213	121027	235256	50248628
Neuromyelitis optica spectrum disorder	143.30	11.46	59	121181	767	50483117
Cough	143.15	11.46	223	121017	241041	50242843
Coordination abnormal	141.71	11.46	156	121084	11378	50472506
Progressive multiple sclerosis	141.49	11.46	57	121183	698	50483186
Maternal exposure timing unspecified	141.10	11.46	95	121145	3525	50480359
Malignant neoplasm progression	140.89	11.46	5	121235	68119	50415765
Therapeutic product effect decreased	138.10	11.46	77	121163	135973	50347911
Systemic lupus erythematosus	136.49	11.46	84	121156	140538	50343346
Injection site cellulitis	135.64	11.46	63	121177	1112	50482772
Injection site mass	135.00	11.46	177	121063	15503	50468381
Abortion	134.59	11.46	76	121164	2048	50481836
Cerebrovascular accident	134.45	11.46	515	120725	94165	50389719
Injection site atrophy	132.74	11.46	49	121191	465	50483419
Diabetes mellitus	132.67	11.46	334	120906	48699	50435185
Therapeutic product effect incomplete	131.74	11.46	29	121211	91486	50392398
Thyroid cancer	131.26	11.46	96	121144	4073	50479811
Pruritus	129.09	11.46	307	120933	283261	50200623
Mobility decreased	127.04	11.46	451	120789	79497	50404387
Alopecia	126.72	11.46	247	120993	244800	50239084
Muscle spasms	124.61	11.46	613	120627	124940	50358944
Pericarditis	123.77	11.46	20	121220	78669	50405215
Swelling	120.71	11.46	184	121056	200688	50283196
Hyponatraemia	118.72	11.46	41	121199	96098	50387786
Lower respiratory tract infection	118.60	11.46	40	121200	95161	50388723
Caesarean section	117.14	11.46	165	121075	15474	50468410
Injection site induration	114.47	11.46	120	121120	8277	50475607
Head injury	114.34	11.46	206	121034	23814	50460070
Adverse drug reaction	114.34	11.46	341	120899	54881	50429003
Pancytopenia	114.33	11.46	30	121210	84000	50399884
C-reactive protein increased	113.77	11.46	13	121227	66461	50417423
Post procedural complication	112.60	11.46	159	121081	14945	50468939
Adverse reaction	112.25	11.46	120	121120	8466	50475418
Intentional product use issue	109.45	11.46	25	121215	76893	50406991
Lower limb fracture	106.25	11.46	150	121090	14096	50469788
Breast cancer in situ	103.86	11.46	56	121184	1375	50482509
Blood creatinine increased	102.08	11.46	28	121212	76132	50407752
Neurogenic bladder	101.94	11.46	71	121169	2786	50481098
Hyperkalaemia	97.82	11.46	4	121236	48085	50435799
Paraesthesia	97.31	11.46	555	120685	119688	50364196
Electrocardiogram QT prolonged	97.23	11.46	7	121233	51879	50432005
Decreased appetite	96.65	11.46	211	121029	200712	50283172
Relapsing-remitting multiple sclerosis	95.54	11.46	38	121202	449	50483435
Hypokalaemia	94.90	11.46	46	121194	87946	50395938
Breast cancer stage I	94.21	11.46	59	121181	1931	50481953
Visual impairment	94.13	11.46	368	120872	67907	50415977
Blindness unilateral	94.07	11.46	87	121153	5148	50478736
Tremor	94.06	11.46	532	120708	114371	50369513
Multiple sclerosis	94.05	11.46	173	121067	20320	50463564
Migraine	93.64	11.46	393	120847	74887	50408997
Malignant melanoma	93.12	11.46	118	121122	9990	50473894
Nephrolithiasis	92.46	11.46	235	121005	34458	50449426
Drug abuse	92.36	11.46	16	121224	59830	50424054
Amnesia	91.33	11.46	265	120975	41995	50441889
Phobia	90.74	11.46	33	121207	299	50483585
Hip fracture	89.11	11.46	194	121046	25737	50458147
Intracranial aneurysm	88.71	11.46	69	121171	3215	50480669
Drug delivery device placement	88.63	11.46	25	121215	87	50483797
Cystitis	88.31	11.46	271	120969	44293	50439591
Breast cancer stage II	88.04	11.46	53	121187	1614	50482270
Hemiparesis	87.95	11.46	166	121074	19882	50464002
Anaemia	86.66	11.46	312	120928	252144	50231740
Vomiting	86.63	11.46	698	120542	460060	50023824
Helicobacter infection	84.35	11.46	10	121230	49692	50434192
Therapeutic response decreased	84.01	11.46	8	121232	47223	50436661
Haemoglobin decreased	83.86	11.46	109	121131	127107	50356777
Upper limb fracture	81.84	11.46	141	121099	15732	50468152
Ovarian cancer	80.05	11.46	79	121161	5070	50478814
Injection site discolouration	79.97	11.46	91	121149	6883	50477001
Thrombocytopenia	78.53	11.46	115	121125	127558	50356326
Procedural anxiety	78.10	11.46	36	121204	624	50483260
Asthenia	77.46	11.46	1132	120108	317910	50165974
Loss of personal independence in daily activities	76.48	11.46	36	121204	70014	50413870
Sensory disturbance	75.85	11.46	116	121124	11713	50472171
Blister	74.88	11.46	57	121183	85361	50398523
Mucosal inflammation	73.56	11.46	6	121234	40136	50443748
Wound	73.55	11.46	87	121153	105707	50378177
Oxygen saturation decreased	73.51	11.46	42	121198	73206	50410678
Pleural effusion	73.15	11.46	53	121187	81401	50402483
Drug specific antibody present	72.51	11.46	62	121178	3306	50480578
Interstitial lung disease	72.29	11.46	19	121221	53157	50430727
Oedema	72.22	11.46	39	121201	70142	50413742
Psoriatic arthropathy	71.65	11.46	13	121227	47019	50436865
Psoriasis	71.51	11.46	38	121202	68962	50414922
Folliculitis	71.50	11.46	6	121234	39219	50444665
Dyspnoea exertional	70.23	11.46	18	121222	51215	50432669
Staphylococcal infection	70.01	11.46	216	121024	35400	50448484
Kidney infection	69.90	11.46	145	121095	18601	50465283
Cholelithiasis	69.79	11.46	225	121015	37748	50446136
Neutralising antibodies positive	69.18	11.46	25	121215	222	50483662
Tachycardia	68.33	11.46	83	121157	99680	50384204
Dysgraphia	67.55	11.46	54	121186	2619	50481265
Appendicitis	66.92	11.46	81	121159	6543	50477341
Injection site nodule	66.76	11.46	59	121181	3289	50480595
Muscle injury	66.76	11.46	6	121234	37105	50446779
Lung neoplasm malignant	66.42	11.46	127	121113	15357	50468527
Dysstasia	65.47	11.46	137	121103	17682	50466202
Intentional overdose	65.40	11.46	34	121206	62470	50421414
Wheezing	64.55	11.46	34	121206	62013	50421871
Metabolic acidosis	63.03	11.46	9	121231	38816	50445068
Meningioma benign	62.66	11.46	25	121215	298	50483586
Hospitalisation	62.59	11.46	43	121197	67894	50415990
Arthropathy	62.57	11.46	183	121057	157723	50326161
Hypoglycaemia	62.51	11.46	25	121215	53556	50430328
Injection site ulcer	62.28	11.46	29	121211	515	50483369
Mental impairment	62.11	11.46	107	121133	11937	50471947
Blindness	61.39	11.46	131	121109	17138	50466746
Lack of injection site rotation	61.15	11.46	24	121216	273	50483611
Lactic acidosis	61.08	11.46	5	121235	33350	50450534
Productive cough	60.80	11.46	25	121215	52669	50431215
Thrombosis	60.69	11.46	280	120960	55553	50428331
Neuropathy peripheral	60.62	11.46	86	121154	96671	50387213
Multiple organ dysfunction syndrome	59.53	11.46	23	121217	50314	50433570
Gastric bypass	58.84	11.46	39	121201	1409	50482475
Endometriosis	58.72	11.46	60	121180	4015	50479869
Temperature intolerance	58.63	11.46	81	121159	7458	50476426
Speech disorder	58.55	11.46	203	121037	35345	50448539
Injury associated with device	58.34	11.46	53	121187	3064	50480820
Somnolence	58.27	11.46	184	121056	154801	50329083
Neutrophil count decreased	57.89	11.46	19	121221	46007	50437877
Ligament rupture	57.75	11.46	49	121191	2585	50481299
Bradycardia	57.74	11.46	42	121198	64384	50419500
Anxiety	57.67	11.46	665	120575	176941	50306943
Epilepsy	57.36	11.46	146	121094	21421	50462463
Diplopia	57.18	11.46	136	121104	19124	50464760
Generalised tonic-clonic seizure	56.85	11.46	165	121075	26145	50457739
Hypertension	56.24	11.46	762	120478	210441	50273443
Invasive ductal breast carcinoma	55.94	11.46	70	121170	5851	50478033
Intervertebral disc disorder	55.35	11.46	60	121180	4300	50479584
Cervix carcinoma	55.01	11.46	47	121193	2503	50481381
General physical health deterioration	54.32	11.46	168	121072	142266	50341618
International normalised ratio increased	53.95	11.46	18	121222	43134	50440750
Procedural pain	53.94	11.46	109	121131	13723	50470161
Scar	53.26	11.46	99	121141	11719	50472165
Influenza	53.06	11.46	382	120858	89156	50394728
Primary progressive multiple sclerosis	52.61	11.46	16	121224	77	50483807
Appendicitis perforated	52.08	11.46	37	121203	1499	50482385
Suicidal ideation	51.76	11.46	266	120974	55119	50428765
Renal impairment	51.75	11.46	63	121177	75598	50408286
Hypoxia	51.74	11.46	29	121211	51094	50432790
Agraphia	51.26	11.46	13	121227	26	50483858
Overdose	51.04	11.46	101	121139	99626	50384258
Intraductal proliferative breast lesion	50.97	11.46	45	121195	2505	50481379
Cervical spinal stenosis	50.70	11.46	40	121200	1903	50481981
Concussion	50.60	11.46	76	121164	7552	50476332
Basedow's disease	50.39	11.46	21	121219	282	50483602
Cardiac failure	50.25	11.46	65	121175	75975	50407909
Feeling abnormal	50.14	11.46	490	120750	125002	50358882
Autoimmune hepatitis	50.00	11.46	75	121165	7444	50476440
Platelet count decreased	49.86	11.46	104	121136	100622	50383262
Constipation	49.82	11.46	252	120988	185456	50298428
Blood pressure systolic increased	49.47	11.46	12	121228	35437	50448447
Gastrointestinal haemorrhage	49.15	11.46	62	121178	73259	50410625
Lumbar spinal stenosis	48.99	11.46	55	121185	4099	50479785
Discomfort	48.68	11.46	118	121122	108262	50375622
Postoperative wound infection	48.65	11.46	79	121161	8396	50475488
Spinal stenosis	48.41	11.46	103	121137	13447	50470437
Treatment failure	47.89	11.46	169	121071	137468	50346416
Retinal exudates	47.37	11.46	26	121214	662	50483222
Aphasia	47.17	11.46	163	121077	28331	50455553
Mouth ulceration	46.67	11.46	6	121234	28018	50455866
Intentional product misuse	46.59	11.46	27	121213	46707	50437177
Hypocalcaemia	46.49	11.46	5	121235	26811	50457073
Meningioma	46.49	11.46	49	121191	3400	50480484
Sinusitis	46.00	11.46	231	121009	170327	50313557
Cardio-respiratory arrest	45.91	11.46	37	121203	53855	50430029
Cholecystectomy	45.82	11.46	81	121159	9222	50474662
Injection site scab	45.71	11.46	21	121219	361	50483523
Nasal congestion	44.93	11.46	34	121206	51086	50432798
Uterine cancer	44.06	11.46	50	121190	3770	50480114
Product quality issue	43.94	11.46	10	121230	30848	50453036
Depressed level of consciousness	43.84	11.46	36	121204	51917	50431967
Erythema	43.78	11.46	191	121049	146223	50337661
Sedation	43.43	11.46	10	121230	30600	50453284
Malaise	42.79	11.46	1079	120161	334453	50149431
Frustration tolerance decreased	42.69	11.46	60	121180	5614	50478270
Clostridial infection	42.29	11.46	50	121190	3940	50479944
Sarcoidosis	42.20	11.46	56	121184	4961	50478923
Neoplasm malignant	42.20	11.46	139	121101	23576	50460308
Bipolar disorder	41.55	11.46	65	121175	6692	50477192
Paralysis	40.84	11.46	74	121166	8590	50475294
Septic shock	40.82	11.46	46	121194	57129	50426755
Colon cancer	40.67	11.46	74	121166	8617	50475267
Ovarian cyst	40.65	11.46	98	121142	13898	50469986
Thyroid disorder	40.35	11.46	92	121148	12585	50471299
Pulmonary thrombosis	40.21	11.46	68	121172	7473	50476411
Intervertebral disc degeneration	39.90	11.46	95	121145	13366	50470518
Ruptured cerebral aneurysm	39.49	11.46	20	121220	430	50483454
Band sensation	39.21	11.46	23	121217	667	50483217
Focal dyscognitive seizures	38.96	11.46	40	121200	2692	50481192
Respiratory failure	38.83	11.46	102	121138	91079	50392805
Depressed mood	38.74	11.46	173	121067	33850	50450034
Medication error	38.72	11.46	19	121221	36085	50447799
Therapy non-responder	38.71	11.46	39	121201	50983	50432901
Injection site calcification	38.48	11.46	10	121230	23	50483861
Paraparesis	38.44	11.46	35	121205	2029	50481855
Accidental exposure to product	38.24	11.46	5	121235	23052	50460832
Micturition urgency	38.21	11.46	70	121170	8194	50475690
Bladder cancer	37.40	11.46	43	121197	3289	50480595
Motor dysfunction	37.10	11.46	68	121172	7963	50475921
Burning sensation	36.86	11.46	210	121030	45236	50438648
Autoimmune thyroiditis	36.21	11.46	42	121198	3243	50480641
Weight increased	35.91	11.46	310	120930	201581	50282303
Oral pain	35.87	11.46	8	121232	25025	50458859
Abdominal pain upper	35.79	11.46	229	121011	159080	50324804
Pneumonitis	35.70	11.46	13	121227	29497	50454387
Dyspepsia	35.42	11.46	78	121162	74019	50409865
Feeling cold	35.22	11.46	115	121125	19416	50464468
Serotonin syndrome	35.21	11.46	8	121232	24705	50459179
Injection site injury	35.18	11.46	20	121220	546	50483338
Paraplegia	35.12	11.46	36	121204	2418	50481466
Muscle atrophy	35.06	11.46	57	121183	6064	50477820
Bladder dysfunction	34.91	11.46	22	121218	728	50483156
Hypervolaemia	34.87	11.46	9	121231	25490	50458394
Blood creatine phosphokinase increased	34.75	11.46	10	121230	26357	50457527
Surgery	34.70	11.46	154	121086	30051	50453833
Neutralising antibodies	34.57	11.46	10	121230	39	50483845
Haematochezia	34.45	11.46	27	121213	39855	50444029
Brain neoplasm benign	34.35	11.46	14	121226	177	50483707
Rhabdomyolysis	34.24	11.46	26	121214	39001	50444883
Nerve compression	34.24	11.46	63	121177	7399	50476485
Ascites	33.96	11.46	22	121218	35839	50448045
Condition aggravated	33.96	11.46	504	120736	296554	50187330
Red blood cell sedimentation rate increased	33.86	11.46	14	121226	29402	50454482
Reaction to preservatives	33.53	11.46	14	121226	189	50483695
Incorrect dose administered	33.43	11.46	40	121200	48374	50435510
Papillary thyroid cancer	33.36	11.46	32	121208	1983	50481901
Procedural complication	33.35	11.46	49	121191	4774	50479110
Myelitis transverse	33.19	11.46	24	121216	1000	50482884
Tibia fracture	33.19	11.46	47	121193	4428	50479456
Ectopic pregnancy	33.05	11.46	34	121206	2293	50481591
Abdominal distension	33.02	11.46	79	121161	72824	50411060
Oedema peripheral	33.01	11.46	232	121008	157729	50326155
Rash pruritic	32.54	11.46	40	121200	47806	50436078
Appendicectomy	32.53	11.46	35	121205	2487	50481397
Meniscus injury	32.51	11.46	56	121184	6246	50477638
Drug level increased	32.39	11.46	4	121236	19264	50464620
Inflammation	32.36	11.46	54	121186	56858	50427026
Full blood count decreased	32.30	11.46	7	121233	22339	50461545
Bone marrow failure	32.04	11.46	13	121227	27611	50456273
Agitation	31.91	11.46	49	121191	53335	50430549
Injection site fibrosis	31.88	11.46	8	121232	15	50483869
Drug resistance	31.78	11.46	4	121236	18985	50464899
Benign breast neoplasm	31.50	11.46	24	121216	1084	50482800
Vision blurred	31.35	11.46	307	120933	78340	50405544
Optic nerve disorder	31.28	11.46	20	121220	679	50483205
Expanded disability status scale score increased	31.18	11.46	16	121224	354	50483530
Injury	31.12	11.46	43	121197	48882	50435002
Thyroid neoplasm	30.82	11.46	40	121200	3467	50480417
Agranulocytosis	30.38	11.46	7	121233	21414	50462470
Liver function test abnormal	30.32	11.46	196	121044	44143	50439741
Rhinorrhoea	30.21	11.46	48	121192	51535	50432349
Decreased immune responsiveness	30.13	11.46	42	121198	3899	50479985
Poor venous access	29.60	11.46	72	121168	10268	50473616
Pulmonary sarcoidosis	29.53	11.46	21	121219	852	50483032
Mammoplasty	29.26	11.46	17	121223	484	50483400
Breech presentation	29.21	11.46	23	121217	1091	50482793
Drug dependence	28.95	11.46	6	121234	19753	50464131
Blood calcium decreased	28.91	11.46	7	121233	20699	50463185
Injection site inflammation	28.86	11.46	37	121203	3168	50480716
Gallbladder disorder	28.78	11.46	97	121143	16645	50467239
Rotator cuff syndrome	28.49	11.46	76	121164	11468	50472416
Atrial fibrillation	28.45	11.46	136	121104	101609	50382275
Central venous catheterisation	28.25	11.46	30	121210	2100	50481784
Product administered at inappropriate site	28.22	11.46	32	121208	2411	50481473
Drug ineffective for unapproved indication	28.18	11.46	8	121232	21273	50462611
Haemorrhage in pregnancy	28.02	11.46	27	121213	1682	50482202
Prolonged labour	27.97	11.46	17	121223	527	50483357
Upper gastrointestinal haemorrhage	27.77	11.46	3	121237	16032	50467852
COVID-19	27.73	11.46	43	121197	46619	50437265
Anal incontinence	27.71	11.46	75	121165	11415	50472469
Epistaxis	27.64	11.46	71	121169	63883	50420001
Diplegia	27.63	11.46	21	121219	945	50482939
Product prescribing error	27.53	11.46	8	121232	20953	50462931
Colon cancer stage III	27.46	11.46	10	121230	91	50483793
Pain in jaw	27.34	11.46	31	121209	38397	50445487
Varicose vein	27.33	11.46	42	121198	4258	50479626
Cytomegalovirus infection	27.28	11.46	5	121235	17957	50465927
Irritable bowel syndrome	27.27	11.46	51	121189	51390	50432494
No adverse event	27.12	11.46	155	121085	33423	50450461
Rash maculo-papular	27.12	11.46	15	121225	26626	50457258
Brain neoplasm	27.06	11.46	39	121201	3734	50480150
Fluid retention	27.04	11.46	50	121190	50599	50433285
Osteoarthritis	26.95	11.46	267	120973	68339	50415545
JC polyomavirus test	26.74	11.46	8	121232	36	50483848
Ataxia	26.52	11.46	83	121157	13703	50470181
Retinal tear	26.44	11.46	21	121219	1009	50482875
Cholestasis	26.29	11.46	14	121226	25387	50458497
Haemolytic uraemic syndrome	26.15	11.46	30	121210	2289	50481595
Raynaud's phenomenon	26.03	11.46	22	121218	1154	50482730
Anaphylactic reaction	25.75	11.46	57	121183	53998	50429886
Fear	25.64	11.46	85	121155	14464	50469420
Vertigo	25.60	11.46	212	121028	51620	50432264
Chronic leukaemia	25.60	11.46	6	121234	7	50483877
Injection site irritation	25.58	11.46	41	121199	4309	50479575
Hypercalcaemia	25.48	11.46	12	121228	23340	50460544
Porphyria non-acute	25.48	11.46	13	121227	284	50483600
Mental disorder	25.17	11.46	112	121128	21879	50462005
Delirium	24.86	11.46	33	121207	38159	50445725
Oropharyngeal pain	24.79	11.46	99	121141	77702	50406182
Pneumocystis jirovecii pneumonia	24.75	11.46	3	121237	14660	50469224
Hernia	24.75	11.46	64	121176	9479	50474405
Back disorder	24.75	11.46	63	121177	9242	50474642
Eosinophilia	24.72	11.46	7	121233	18645	50465239
Rectocele	24.71	11.46	19	121221	870	50483014
Muscle tightness	24.69	11.46	67	121173	10213	50473671
Ligament sprain	24.68	11.46	68	121172	10457	50473427
Vitamin D decreased	24.56	11.46	59	121181	8347	50475537
Obstructive airways disorder	24.55	11.46	4	121236	15648	50468236
Cellulitis staphylococcal	24.48	11.46	17	121223	664	50483220
Uterine disorder	24.46	11.46	31	121209	2624	50481260
Hepatitis C	24.46	11.46	43	121197	4874	50479010
Chronic kidney disease	24.26	11.46	36	121204	39735	50444149
Pain in extremity	23.72	11.46	837	120403	272028	50211856
Anti-interferon antibody positive	23.66	11.46	6	121234	12	50483872
Headache	23.55	11.46	1459	119781	505076	49978808
Benign lung neoplasm	23.43	11.46	8	121232	59	50483825
Illness	23.31	11.46	15	121225	24525	50459359
Neuralgia	23.27	11.46	109	121131	21754	50462130
Blood pressure fluctuation	23.27	11.46	31	121209	35792	50448092
Thyroid function test abnormal	23.25	11.46	34	121206	3298	50480586
Intervertebral disc operation	23.08	11.46	16	121224	623	50483261
Throat irritation	23.07	11.46	23	121217	30216	50453668
Knee arthroplasty	23.02	11.46	156	121084	35690	50448194
Dysgeusia	22.99	11.46	36	121204	38880	50445004
Fibula fracture	22.88	11.46	32	121208	2980	50480904
Blood pressure diastolic decreased	22.80	11.46	6	121234	16775	50467109
Dry skin	22.73	11.46	43	121197	43148	50440736
Blood potassium decreased	22.67	11.46	159	121081	36786	50447098
Withdrawal syndrome	22.58	11.46	7	121233	17583	50466301
Haematuria	22.55	11.46	17	121223	25596	50458288
Breast cancer recurrent	22.54	11.46	36	121204	3772	50480112
Endometrial cancer	22.45	11.46	31	121209	2852	50481032
Cellulitis	22.45	11.46	264	120976	70534	50413350
Heavy menstrual bleeding	22.42	11.46	85	121155	15452	50468432
Thermal burn	22.37	11.46	41	121199	4800	50479084
Calculus bladder	22.34	11.46	15	121225	554	50483330
Injection site anaesthesia	22.32	11.46	7	121233	38	50483846
Urinary tract disorder	22.26	11.46	28	121212	2352	50481532
Tachypnoea	22.26	11.46	4	121236	14573	50469311
Partial seizures	22.23	11.46	41	121199	4824	50479060
Hemianaesthesia	22.16	11.46	13	121227	377	50483507
Febrile convulsion	22.16	11.46	13	121227	377	50483507
Angioedema	22.12	11.46	35	121205	37641	50446243
Conversion disorder	22.09	11.46	23	121217	1573	50482311
Acute respiratory failure	21.83	11.46	22	121218	28760	50455124
Nerve injury	21.66	11.46	56	121184	8294	50475590
Dry eye	21.65	11.46	27	121213	32068	50451816
Dry mouth	21.58	11.46	66	121174	56112	50427772
Cartilage injury	21.55	11.46	23	121217	1619	50482265
Leukopenia	21.46	11.46	86	121154	67442	50416442
Rubber sensitivity	21.41	11.46	24	121216	1785	50482099
Wound infection staphylococcal	21.36	11.46	28	121212	2451	50481433
Fear of injection	21.35	11.46	46	121194	6057	50477827
Face oedema	21.34	11.46	8	121232	17831	50466053
Haematemesis	21.25	11.46	21	121219	27704	50456180
Scoliosis	21.23	11.46	48	121192	6528	50477356
Haemoptysis	21.23	11.46	18	121222	25555	50458329
Product substitution issue	21.16	11.46	4	121236	14053	50469831
Gallbladder operation	21.12	11.46	25	121215	1972	50481912
Chronic lymphocytic leukaemia	21.12	11.46	27	121213	2306	50481578
Blindness transient	21.11	11.46	32	121208	3206	50480678
Suicidal behaviour	21.11	11.46	27	121213	2307	50481577
Intervertebral disc injury	21.07	11.46	9	121231	129	50483755
Incontinence	20.97	11.46	62	121178	9923	50473961
Goitre	20.83	11.46	42	121198	5278	50478606
Rash erythematous	20.82	11.46	32	121208	34820	50449064
Orthostatic hypotension	20.73	11.46	24	121216	29457	50454427
Dysarthria	20.67	11.46	157	121083	37246	50446638
Pulmonary oedema	20.63	11.46	55	121185	48883	50435001
Gun shot wound	20.54	11.46	8	121232	89	50483795
Foot fracture	20.54	11.46	99	121141	19992	50463892
Lumbar radiculopathy	20.39	11.46	23	121217	1723	50482161
Impaired self-care	20.33	11.46	23	121217	1728	50482156
Cervical dysplasia	20.29	11.46	29	121211	2756	50481128
Facial bones fracture	20.15	11.46	31	121209	3146	50480738
Benign hydatidiform mole	20.00	11.46	8	121232	96	50483788
Disseminated intravascular coagulation	19.97	11.46	8	121232	17127	50466757
Knee operation	19.72	11.46	39	121201	4834	50479050
Limb mass	19.70	11.46	28	121212	2647	50481237
Progesterone receptor assay positive	19.66	11.46	11	121229	291	50483593
Abnormal labour	19.59	11.46	7	121233	60	50483824
Breast cancer stage III	19.58	11.46	31	121209	3225	50480659
Panic attack	19.55	11.46	95	121145	19247	50464637
Demyelination	19.47	11.46	44	121196	5982	50477902
Urosepsis	19.41	11.46	81	121159	15384	50468500
Wrong technique in product usage process	19.40	11.46	68	121172	55442	50428442
Schwannoma	19.39	11.46	7	121233	62	50483822
Hyperglycaemia	19.37	11.46	36	121204	36369	50447515
Lipoatrophy	19.29	11.46	11	121229	302	50483582
Cholecystitis infective	19.28	11.46	21	121219	1513	50482371
Precancerous cells present	19.27	11.46	19	121221	1218	50482666
Fractured coccyx	19.26	11.46	17	121223	946	50482938
Wrist fracture	19.26	11.46	66	121174	11421	50472463
Fat necrosis	19.20	11.46	14	121226	591	50483293
Pollakiuria	19.20	11.46	110	121130	23741	50460143
Renal cell carcinoma	19.19	11.46	30	121210	3087	50480797
Emotional disorder	18.97	11.46	67	121173	11769	50472115
Spinal disorder	18.97	11.46	53	121187	8217	50475667
Incision site abscess	18.87	11.46	9	121231	169	50483715
Coronary artery disease	18.87	11.46	129	121111	29597	50454287
Frequent bowel movements	18.86	11.46	5	121235	13913	50469971
Rectal cancer	18.83	11.46	22	121218	1712	50482172
Creatinine renal clearance decreased	18.72	11.46	3	121237	11878	50472006
Gastrointestinal disorder	18.62	11.46	141	121099	94315	50389569
Foetal heart rate abnormal	18.60	11.46	13	121227	513	50483371
Skin cancer	18.48	11.46	57	121183	9337	50474547
Plasma cell myeloma	18.48	11.46	29	121211	31293	50452591
Ocular hyperaemia	18.47	11.46	13	121227	20279	50463605
Gait spastic	18.35	11.46	10	121230	251	50483633
Bone erosion	18.30	11.46	3	121237	11684	50472200
Oestrogen receptor assay positive	18.17	11.46	12	121228	431	50483453
Heat exhaustion	18.13	11.46	7	121233	76	50483808
Deafness unilateral	18.09	11.46	27	121213	2668	50481216
Oral candidiasis	17.99	11.46	9	121231	16906	50466978
Focal segmental glomerulosclerosis	17.98	11.46	19	121221	1322	50482562
Umbilical cord around neck	17.96	11.46	9	121231	189	50483695
Tubulointerstitial nephritis	17.90	11.46	7	121233	15204	50468680
Post procedural infection	17.82	11.46	49	121191	7527	50476357
Lung adenocarcinoma stage I	17.82	11.46	5	121235	17	50483867
Shock	17.81	11.46	14	121226	20636	50463248
Colostomy closure	17.77	11.46	8	121232	131	50483753
Arterial occlusive disease	17.70	11.46	37	121203	4771	50479113
Atrophy	17.68	11.46	20	121220	1503	50482381
Spondylolisthesis	17.68	11.46	29	121211	3108	50480776
Crying	17.66	11.46	96	121144	20320	50463564
Umbilical hernia	17.61	11.46	25	121215	2361	50481523
Right ventricular failure	17.60	11.46	8	121232	15885	50467999
Product administration error	17.44	11.46	13	121227	19686	50464198
Incisional hernia	17.43	11.46	19	121221	1370	50482514
Hepatic steatosis	17.41	11.46	109	121131	24275	50459609
Female genital operation	17.39	11.46	5	121235	19	50483865
Volvulus	17.38	11.46	20	121220	1531	50482353
Malignant melanoma in situ	17.38	11.46	15	121225	810	50483074
Oophorectomy	17.36	11.46	12	121228	465	50483419
Hepatocellular injury	17.32	11.46	22	121218	25925	50457959
Rectal haemorrhage	17.28	11.46	42	121198	38516	50445368
Cephalo-pelvic disproportion	17.26	11.46	9	121231	206	50483678
Anaesthetic complication	17.22	11.46	21	121219	1709	50482175
Skin exfoliation	17.22	11.46	34	121206	33578	50450306
JC polyomavirus test positive	17.21	11.46	17	121223	1092	50482792
Infection	17.21	11.46	301	120939	172653	50311231
Hand fracture	17.17	11.46	35	121205	4433	50479451
Incision site complication	17.14	11.46	13	121227	583	50483301
Post procedural haemorrhage	17.08	11.46	47	121193	7223	50476661
Optic atrophy	17.04	11.46	17	121223	1105	50482779
Ovarian neoplasm	16.96	11.46	15	121225	837	50483047
Blood urea increased	16.80	11.46	19	121221	23566	50460318
Magnetic resonance imaging head abnormal	16.77	11.46	21	121219	1756	50482128
Nodule	16.70	11.46	10	121230	16993	50466891
Lacrimation increased	16.68	11.46	10	121230	16982	50466902
Blood pressure decreased	16.65	11.46	73	121167	55836	50428048
Breast calcifications	16.63	11.46	17	121223	1138	50482746
Intervertebral disc displacement	16.56	11.46	11	121229	399	50483485
Feeling of body temperature change	16.54	11.46	34	121206	4333	50479551
Lumbar puncture	16.44	11.46	6	121234	55	50483829
Post procedural stroke	16.44	11.46	6	121234	55	50483829
Bone pain	16.40	11.46	58	121182	47171	50436713
Lyme disease	16.39	11.46	25	121215	2518	50481366
Haemorrhagic ovarian cyst	16.38	11.46	13	121227	624	50483260
Injection site hypertrophy	16.34	11.46	6	121234	56	50483828
Cervical vertebral fracture	16.32	11.46	23	121217	2157	50481727
Gastric cyst	16.28	11.46	7	121233	102	50483782
Myelosuppression	16.27	11.46	6	121234	13511	50470373
Heat stroke	16.27	11.46	13	121227	630	50483254
Pregnancy	16.26	11.46	124	121116	29453	50454431
Cardiac perforation	16.16	11.46	6	121234	58	50483826
Drug delivery system malfunction	16.14	11.46	15	121225	893	50482991
Thrombotic thrombocytopenic purpura	16.11	11.46	30	121210	3555	50480329
Stevens-Johnson syndrome	16.08	11.46	17	121223	21735	50462149
Carotid artery aneurysm	16.06	11.46	9	121231	239	50483645
Adrenal insufficiency	16.04	11.46	7	121233	14236	50469648
Skin graft	16.00	11.46	12	121228	529	50483355
Cardiac arrest	15.96	11.46	126	121114	83525	50400359
Skull fracture	15.89	11.46	15	121225	911	50482973
Cerebral cyst	15.89	11.46	9	121231	244	50483640
Enterocele	15.89	11.46	6	121234	61	50483823
Vaccination complication	15.88	11.46	14	121226	778	50483106
Basal cell carcinoma	15.81	11.46	103	121137	23253	50460631
Tumefactive multiple sclerosis	15.72	11.46	6	121234	63	50483821
Fibrocystic breast disease	15.69	11.46	16	121224	1068	50482816
Urinary tract infection staphylococcal	15.63	11.46	9	121231	252	50483632
Vein disorder	15.62	11.46	33	121207	4286	50479598
Lung disorder	15.57	11.46	55	121185	44744	50439140
Viral pericarditis	15.53	11.46	5	121235	30	50483854
Tenderness	15.49	11.46	13	121227	18552	50465332
Respiratory distress	15.48	11.46	31	121209	30458	50453426
Spider vein	15.47	11.46	9	121231	257	50483627
Muscle disorder	15.46	11.46	33	121207	4317	50479567
Aneurysm	15.41	11.46	24	121216	2461	50481423
Cholecystitis	15.39	11.46	70	121170	13801	50470083
Cerebral atrophy	15.32	11.46	34	121206	4567	50479317
Restlessness	15.14	11.46	23	121217	25150	50458734
Hypersensitivity	15.12	11.46	396	120844	214765	50269119
Faeces discoloured	15.12	11.46	10	121230	16114	50467770
Biopsy bladder	15.11	11.46	3	121237	0	50483884
Rectal cancer stage I	15.11	11.46	3	121237	0	50483884
Breast dysplasia	15.11	11.46	3	121237	0	50483884
Urinary control neurostimulator implantation	15.11	11.46	3	121237	0	50483884
Neurological complication associated with device	15.11	11.46	3	121237	0	50483884
Face presentation	15.11	11.46	3	121237	0	50483884
Neurilemmoma benign	15.11	11.46	3	121237	0	50483884
Urinary retention	15.07	11.46	111	121129	26079	50457805
Myoclonus	14.94	11.46	8	121232	14462	50469422
Large intestine polyp	14.90	11.46	45	121195	7287	50476597
Paraganglion neoplasm	14.89	11.46	4	121236	11	50483873
Injection related reaction	14.85	11.46	12	121228	591	50483293
Uterine mass	14.83	11.46	9	121231	278	50483606
Injection site hypoaesthesia	14.83	11.46	10	121230	372	50483512
Acute disseminated encephalomyelitis	14.78	11.46	8	121232	198	50483686
Rales	14.68	11.46	3	121237	9975	50473909
Paternal exposure before pregnancy	14.63	11.46	5	121235	37	50483847
Musculoskeletal pain	14.58	11.46	107	121133	72070	50411814
Skin laceration	14.58	11.46	86	121154	18756	50465128
Loss of consciousness	14.58	11.46	340	120900	104013	50379871
Oophorectomy bilateral	14.51	11.46	5	121235	38	50483846
Postoperative thrombosis	14.51	11.46	7	121233	135	50483749
Hypothyroidism	14.47	11.46	135	121105	33990	50449894
Hepatotoxicity	14.42	11.46	27	121213	27199	50456685
Colon cancer metastatic	14.42	11.46	15	121225	1025	50482859
Pancreatic cyst	14.41	11.46	17	121223	1336	50482548
Glioblastoma	14.38	11.46	13	121227	747	50483137
Circulatory collapse	14.37	11.46	16	121224	19984	50463900
Diabetic ketoacidosis	14.33	11.46	13	121227	17859	50466025
Homicidal ideation	14.32	11.46	19	121221	1683	50482201
Abdominal operation	14.26	11.46	11	121229	506	50483378
Endometrial cancer stage I	14.05	11.46	8	121232	219	50483665
Chondropathy	14.04	11.46	21	121219	2079	50481805
Malignant hypertension	14.02	11.46	15	121225	1059	50482825
Endometrial adenocarcinoma	14.01	11.46	15	121225	1060	50482824
Lung cancer metastatic	14.00	11.46	22	121218	2273	50481611
Spinal meningeal cyst	13.98	11.46	5	121235	43	50483841
Inappropriate antidiuretic hormone secretion	13.97	11.46	7	121233	13136	50470748
Product complaint	13.95	11.46	5	121235	11461	50472423
Uterine leiomyosarcoma	13.95	11.46	4	121236	15	50483869
Reproductive tract disorder	13.89	11.46	7	121233	149	50483735
Spinal fusion surgery	13.85	11.46	30	121210	3965	50479919
Arthritis	13.84	11.46	288	120952	86433	50397451
Meningitis viral	13.84	11.46	16	121224	1231	50482653
Incoherent	13.80	11.46	31	121209	4199	50479685
Rib fracture	13.77	11.46	86	121154	19135	50464749
Serum serotonin decreased	13.75	11.46	4	121236	16	50483868
Joint effusion	13.74	11.46	7	121233	13014	50470870
Intervertebral disc compression	13.67	11.46	14	121226	939	50482945
Gastrointestinal viral infection	13.67	11.46	14	121226	939	50482945
Intestinal cyst	13.62	11.46	6	121234	93	50483791
Normal newborn	13.54	11.46	41	121199	6650	50477234
Toxic skin eruption	13.53	11.46	5	121235	11246	50472638
Limb injury	13.52	11.46	89	121151	20161	50463723
Blood bilirubin increased	13.51	11.46	36	121204	32002	50451882
Cardiac disorder	13.50	11.46	160	121080	42819	50441065
Nephrotic syndrome	13.42	11.46	33	121207	4737	50479147
Disease progression	13.36	11.46	156	121084	95710	50388174
Bladder prolapse	13.32	11.46	19	121221	1802	50482082
Colon cancer stage IV	13.28	11.46	6	121234	99	50483785
Injection site rash	13.28	11.46	75	121165	16102	50467782
Benign pancreatic neoplasm	13.20	11.46	4	121236	19	50483865
Swelling face	13.17	11.46	73	121167	52522	50431362
Suture related complication	13.16	11.46	7	121233	167	50483717
Lung adenocarcinoma	13.15	11.46	30	121210	4104	50479780
Renal tubular necrosis	13.14	11.46	4	121236	10164	50473720
Adenomyosis	13.08	11.46	10	121230	454	50483430
Colostomy infection	13.04	11.46	3	121237	3	50483881
Intestinal ulcer perforation	13.04	11.46	3	121237	3	50483881
Cardiogenic shock	12.92	11.46	11	121229	15588	50468296
Adverse event	12.91	11.46	161	121079	43602	50440282
Ophthalmoplegia	12.91	11.46	16	121224	1324	50482560
Amniotic fluid volume decreased	12.91	11.46	10	121230	463	50483421
Hyperaesthesia	12.87	11.46	46	121194	8127	50475757
Eye pruritus	12.84	11.46	7	121233	12527	50471357
Exposure via father	12.82	11.46	8	121232	260	50483624
Fatigue	12.77	11.46	1906	119334	705695	49778189
Lipoma excision	12.71	11.46	4	121236	22	50483862
Dysphonia	12.69	11.46	49	121191	38843	50445041
Encephalopathy	12.67	11.46	40	121200	33671	50450213
Device dislocation	12.66	11.46	20	121220	21526	50462358
Spinal cord disorder	12.59	11.46	15	121225	1192	50482692
Non-small cell lung cancer stage IIIB	12.58	11.46	3	121237	4	50483880
Dysphemia	12.57	11.46	21	121219	2285	50481599
Immunology test abnormal	12.56	11.46	4	121236	23	50483861
Renal cancer	12.54	11.46	27	121213	3553	50480331
Hypoalbuminaemia	12.52	11.46	4	121236	9856	50474028
Clavicle fracture	12.47	11.46	24	121216	2915	50480969
Sarcoma	12.47	11.46	9	121231	374	50483510
Inappropriate schedule of product administration	12.43	11.46	111	121129	71720	50412164
Cerebral thrombosis	12.42	11.46	17	121223	1551	50482333
Hepatic adenoma	12.40	11.46	8	121232	276	50483608
Post procedural swelling	12.37	11.46	8	121232	277	50483607
Parkinsonism	12.33	11.46	3	121237	8844	50475040
Myelitis	12.32	11.46	15	121225	1219	50482665
Benign uterine neoplasm	12.28	11.46	4	121236	25	50483859
Uterine polyp	12.28	11.46	18	121222	1750	50482134
Altered state of consciousness	12.26	11.46	21	121219	21889	50461995
Abortion missed	12.26	11.46	17	121223	1571	50482313
Hallucination, visual	12.21	11.46	13	121227	16569	50467315
Ventricular fibrillation	12.19	11.46	5	121235	10554	50473330
Pituitary tumour benign	12.18	11.46	18	121222	1763	50482121
Intentional self-injury	12.17	11.46	23	121217	23089	50460795
Progressive relapsing multiple sclerosis	12.15	11.46	4	121236	26	50483858
Nasal sinus cancer	12.15	11.46	4	121236	26	50483858
Skin indentation	12.15	11.46	4	121236	26	50483858
Female sterilisation	12.14	11.46	10	121230	506	50483378
Back injury	12.13	11.46	41	121199	7044	50476840
Gingival bleeding	12.13	11.46	6	121234	11347	50472537
Allergy to metals	12.13	11.46	10	121230	507	50483377
Hepatic function abnormal	12.12	11.46	39	121201	32642	50451242
Polyneuropathy	12.10	11.46	7	121233	12124	50471760
Injection site swelling	12.04	11.46	153	121087	41620	50442264
Brain operation	12.02	11.46	10	121230	513	50483371
Cast application	12.02	11.46	4	121236	27	50483857
Eye irritation	12.00	11.46	14	121226	17126	50466758
Cold type haemolytic anaemia	11.96	11.46	7	121233	202	50483682
Injection site vesicles	11.96	11.46	22	121218	2583	50481301
Anuria	11.93	11.46	6	121234	11238	50472646
Complication of pregnancy	11.92	11.46	10	121230	519	50483365
Exposure during pregnancy	11.90	11.46	211	121029	120804	50363080
Synovial sarcoma	11.90	11.46	4	121236	28	50483856
Uterine cyst	11.88	11.46	9	121231	403	50483481
Spinal laminectomy	11.86	11.46	11	121229	653	50483231
Suture rupture	11.84	11.46	7	121233	206	50483678
Non-small cell lung cancer stage I	11.83	11.46	3	121237	6	50483878
Lhermitte's sign	11.83	11.46	3	121237	6	50483878
Small cell lung cancer extensive stage	11.83	11.46	3	121237	6	50483878
Facial paralysis	11.82	11.46	61	121179	12654	50471230
Benign neoplasm of thyroid gland	11.81	11.46	13	121227	948	50482936
Urticaria	11.78	11.46	229	121011	129332	50354552
Petit mal epilepsy	11.75	11.46	25	121215	3264	50480620
Patella fracture	11.72	11.46	18	121222	1824	50482060
Large intestinal obstruction	11.67	11.46	18	121222	1831	50482053
Radiculopathy	11.66	11.46	32	121208	4909	50478975
Arterial therapeutic procedure	11.66	11.46	4	121236	30	50483854
Uterine prolapse	11.60	11.46	14	121226	1127	50482757
Vulval cancer	11.60	11.46	11	121229	672	50483212
Pharyngitis	11.52	11.46	15	121225	17488	50466396
Ovarian cancer stage III	11.52	11.46	7	121233	217	50483667
Injection site dryness	11.49	11.46	7	121233	218	50483666

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Multiple sclerosis relapse	3141.53	14.39	914	27880	10505	29535228
Influenza like illness	1417.53	14.39	616	28178	23854	29521879
General symptom	307.22	14.39	84	28710	744	29544989
Gait disturbance	303.39	14.39	365	28429	72984	29472749
Injection site erythema	301.75	14.39	181	28613	13775	29531958
Central nervous system lesion	255.68	14.39	120	28674	5528	29540205
Fall	229.52	14.39	521	28273	176657	29369076
Urinary tract infection	222.28	14.39	311	28483	72043	29473690
Memory impairment	219.19	14.39	221	28573	36249	29509484
Injection site pain	201.18	14.39	200	28594	32246	29513487
Balance disorder	188.31	14.39	203	28591	35967	29509766
Mobility decreased	180.67	14.39	170	28624	25610	29520123
Hypoaesthesia	168.83	14.39	233	28561	53234	29492499
Muscle spasticity	167.87	14.39	86	28708	4797	29540936
Depression	161.87	14.39	294	28500	84853	29460880
Injection site infection	149.04	14.39	49	28745	852	29544881
Cognitive disorder	140.36	14.39	142	28652	23357	29522376
Off label use	140.29	14.39	59	28735	300741	29244992
Acute kidney injury	137.20	14.39	44	28750	265223	29280510
Toxicity to various agents	137.12	14.39	8	28786	173653	29372080
Injection site reaction	132.74	14.39	100	28694	11088	29534645
Progressive multiple sclerosis	131.44	14.39	33	28761	201	29545532
Drug interaction	129.73	14.39	19	28775	197366	29348367
Muscular weakness	123.89	14.39	219	28575	61833	29483900
Optic neuritis	122.29	14.39	60	28734	3049	29542684
Secondary progressive multiple sclerosis	121.54	14.39	34	28760	330	29545403
Loss of control of legs	120.81	14.39	37	28757	505	29545228
Gait inability	120.78	14.39	117	28677	18258	29527475
Injection site cellulitis	119.15	14.39	36	28758	468	29545265
Diarrhoea	107.26	14.39	100	28694	332598	29213135
Magnetic resonance imaging abnormal	106.46	14.39	44	28750	1487	29544246
Myocardial infarction	106.07	14.39	290	28504	110006	29435727
Decubitus ulcer	101.80	14.39	72	28722	7239	29538494
Injection site abscess	99.21	14.39	34	28760	675	29545058
Relapsing-remitting multiple sclerosis	94.29	14.39	33	28761	699	29545034
Needle fatigue	92.72	14.39	31	28763	569	29545164
Dyspnoea	86.82	14.39	115	28679	326617	29219116
Anaemia	84.91	14.39	45	28749	200906	29344827
Trigeminal neuralgia	83.56	14.39	33	28761	989	29544744
Seizure	82.74	14.39	238	28556	92885	29452848
Intervertebral disc protrusion	82.38	14.39	68	28726	8602	29537131
Gait spastic	77.13	14.39	28	28766	662	29545071
Neutropenia	77.10	14.39	17	28777	131694	29414039
Road traffic accident	73.40	14.39	83	28711	15478	29530255
Hypotension	73.02	14.39	50	28744	194304	29351429
Coronary artery occlusion	69.58	14.39	66	28728	10028	29535705
Hypertonic bladder	69.17	14.39	32	28762	1424	29544309
Cystitis	68.47	14.39	60	28734	8232	29537501
Coordination abnormal	68.01	14.39	56	28738	7058	29538675
Injection site induration	67.82	14.39	38	28756	2538	29543195
Bladder disorder	62.32	14.39	37	28757	2757	29542976
Multiple sclerosis	62.24	14.39	48	28746	5506	29540227
Visual impairment	60.70	14.39	106	28688	29602	29516131
Injection site haematoma	58.69	14.39	29	28765	1496	29544237
Thrombocytopenia	58.66	14.39	29	28765	134794	29410939
Musculoskeletal disorder	58.10	14.39	45	28749	5195	29540538
Monoparesis	55.40	14.39	30	28764	1873	29543860
Adverse drug reaction	54.75	14.39	90	28704	23930	29521803
Injection site necrosis	52.35	14.39	18	28776	361	29545372
Neurogenic bladder	51.75	14.39	27	28767	1563	29544170
Ataxia	51.12	14.39	61	28733	12042	29533691
Procedural anxiety	50.83	14.39	9	28785	3	29545730
Injection site scar	50.01	14.39	16	28778	254	29545479
Blood creatinine increased	49.74	14.39	11	28783	85091	29460642
Injection site bruising	49.29	14.39	48	28746	7532	29538201
Prostate cancer	48.19	14.39	88	28706	25439	29520294
Hyponatraemia	48.02	14.39	5	28789	67628	29478105
Anxiety	44.73	14.39	183	28611	85182	29460551
Interstitial lung disease	44.45	14.39	3	28791	57715	29488018
Peroneal nerve palsy	43.87	14.39	29	28765	2610	29543123
Pain	43.71	14.39	301	28493	171131	29374602
Haemoglobin decreased	43.21	14.39	26	28768	108349	29437384
Muscle spasms	42.76	14.39	150	28644	64932	29480801
Drug delivery device placement	42.48	14.39	12	28782	121	29545612
Hyperkalaemia	42.42	14.39	5	28789	61387	29484346
Nausea	42.04	14.39	143	28651	289112	29256621
Micturition urgency	41.84	14.39	37	28757	5136	29540597
Renal impairment	41.00	14.39	14	28780	81319	29464414
Abdominal pain	40.76	14.39	43	28751	135314	29410419
Respiratory failure	40.58	14.39	22	28772	97109	29448624
Product use in unapproved indication	40.39	14.39	17	28777	86858	29458875
Drug abuse	39.84	14.39	14	28780	79869	29465864
Dysstasia	39.72	14.39	50	28744	10424	29535309
Platelet count decreased	39.15	14.39	27	28767	104645	29441088
Pancytopenia	39.10	14.39	16	28778	83152	29462581
Chills	39.05	14.39	155	28639	71145	29474588
Primary progressive multiple sclerosis	38.58	14.39	9	28785	38	29545695
Amnesia	37.70	14.39	74	28720	22569	29523164
Rash	37.18	14.39	81	28713	189738	29355995
Pleural effusion	36.90	14.39	12	28782	71896	29473837
Injection site haemorrhage	36.63	14.39	43	28751	8343	29537390
Decreased appetite	36.59	14.39	53	28741	145289	29400444
Product use issue	36.01	14.39	4	28790	51440	29494293
Glioblastoma	35.90	14.39	18	28776	958	29544775
Bipolar disorder	35.88	14.39	28	28766	3267	29542466
Lower limb fracture	35.43	14.39	29	28765	3623	29542110
Spinal fusion surgery	35.23	14.39	17	28777	832	29544901
Blindness unilateral	34.60	14.39	29	28765	3745	29541988
Generalised tonic-clonic seizure	33.64	14.39	64	28730	19075	29526658
Speech disorder	33.43	14.39	72	28722	23444	29522289
Influenza	33.29	14.39	103	28691	41778	29503955
Drug specific antibody present	32.85	14.39	24	28770	2537	29543196
Hemiparesis	32.63	14.39	54	28740	14432	29531301
Neutralising antibodies positive	32.48	14.39	9	28785	84	29545649
Paralysis	32.39	14.39	33	28761	5464	29540269
Head injury	32.34	14.39	57	28737	16024	29529709
Injury associated with device	32.20	14.39	16	28778	835	29544898
Dysarthria	31.35	14.39	83	28711	30828	29514905
Movement disorder	31.32	14.39	44	28750	10193	29535540
Adverse reaction	31.13	14.39	24	28770	2751	29542982
Hypoglycaemia	30.89	14.39	5	28789	48341	29497392
Tachycardia	30.82	14.39	16	28778	72394	29473339
Concussion	30.46	14.39	21	28773	2025	29543708
Hypokalaemia	30.33	14.39	6	28788	50197	29495536
Cough	30.17	14.39	48	28746	126679	29419054
Lack of injection site rotation	29.24	14.39	9	28785	125	29545608
Asthenia	29.20	14.39	329	28465	214921	29330812
Cerebrovascular accident	29.19	14.39	150	28644	76761	29468972
Staphylococcal infection	28.13	14.39	77	28717	29163	29516570
Gastrointestinal haemorrhage	27.80	14.39	22	28772	79511	29466222
Thyroid cancer	27.70	14.39	17	28777	1345	29544388
Hepatic enzyme increased	27.67	14.39	84	28710	33715	29512018
Agraphia	27.07	14.39	6	28788	19	29545714
Tremor	26.92	14.39	142	28652	73396	29472337
Rhabdomyolysis	26.53	14.39	13	28781	60795	29484938
Ankle fracture	26.41	14.39	24	28770	3452	29542281
Cardiac failure	26.40	14.39	23	28771	79264	29466469
Progressive relapsing multiple sclerosis	25.74	14.39	5	28789	6	29545727
Superficial vein prominence	25.74	14.39	5	28789	6	29545727
Muscle tightness	25.49	14.39	26	28768	4312	29541421
C-reactive protein increased	25.29	14.39	6	28788	44257	29501476
Urinary incontinence	25.21	14.39	52	28742	16429	29529304
Headache	24.96	14.39	269	28525	173738	29371995
Nephrolithiasis	24.65	14.39	67	28727	25267	29520466
Frustration tolerance decreased	24.23	14.39	19	28775	2233	29543500
Fear of injection	24.03	14.39	13	28781	810	29544923
Multiple organ dysfunction syndrome	23.96	14.39	16	28778	63100	29482633
Post procedural complication	23.76	14.39	39	28755	10350	29535383
Diabetes mellitus	23.76	14.39	89	28705	39742	29505991
Neurofibroma	23.74	14.39	4	28790	0	29545733
Paraparesis	23.69	14.39	17	28777	1747	29543986
Septic shock	23.56	14.39	16	28778	62544	29483189
Injection site inflammation	23.35	14.39	12	28782	673	29545060
Cardio-respiratory arrest	23.35	14.39	10	28784	50591	29495142
Paraesthesia	23.27	14.39	109	28685	53736	29491997
Neuropathy peripheral	23.17	14.39	21	28773	71006	29474727
Ascites	22.92	14.39	4	28790	36615	29509118
Neutrophil count decreased	22.83	14.39	7	28787	43560	29502173
Injection site atrophy	22.48	14.39	6	28788	48	29545685
Injection site mass	22.22	14.39	27	28767	5428	29540305
Suicidal ideation	21.91	14.39	79	28715	34637	29511096
Temperature intolerance	21.86	14.39	20	28774	2901	29542832
Overweight	21.79	14.39	15	28779	1443	29544290
Chronic lymphocytic leukaemia	21.75	14.39	22	28772	3611	29542122
Injection site injury	21.65	14.39	8	28786	199	29545534
Completed suicide	21.63	14.39	34	28760	90212	29455521
Cardiac valve rupture	21.51	14.39	4	28790	3	29545730
Dysgraphia	21.50	14.39	17	28777	2021	29543712
Feeling abnormal	21.21	14.39	107	28687	54338	29491395
Epistaxis	21.16	14.39	12	28782	51692	29494041
Rectal haemorrhage	21.14	14.39	4	28790	34545	29511188
Hip arthroplasty	21.13	14.39	22	28772	3736	29541997
Hepatic function abnormal	21.13	14.39	6	28788	39253	29506480
Osteonecrosis	21.08	14.39	43	28751	13476	29532257
Stress	21.07	14.39	57	28737	21433	29524300
Insomnia	20.90	14.39	153	28641	88608	29457125
Blood cholesterol increased	20.19	14.39	46	28748	15549	29530184
Injection site ulcer	20.18	14.39	8	28786	242	29545491
Vein disorder	19.89	14.39	12	28782	920	29544813
Pollakiuria	19.83	14.39	48	28746	16868	29528865
Hospitalisation	19.81	14.39	10	28784	45978	29499755
Diplegia	19.69	14.39	12	28782	937	29544796
Lactic acidosis	19.61	14.39	3	28791	30244	29515489
Stomatitis	19.38	14.39	6	28788	37107	29508626
Intervertebral disc disorder	19.37	14.39	15	28779	1730	29544003
JC polyomavirus test positive	19.37	14.39	10	28784	566	29545167
Intentional product misuse	19.21	14.39	5	28789	34656	29511077
Overdose	19.20	14.39	30	28764	79789	29465944
Feeling cold	19.02	14.39	33	28761	9158	29536575
Surgery	19.01	14.39	38	28756	11741	29533992
Urosepsis	18.96	14.39	36	28758	10710	29535023
Pruritus	18.85	14.39	55	28739	116794	29428939
Blood creatine phosphokinase increased	18.80	14.39	8	28786	40636	29505097
Sensory disturbance	18.64	14.39	25	28769	5544	29540189
Hernia	18.61	14.39	31	28763	8327	29537406
Injection site irritation	18.51	14.39	12	28782	1045	29544688
Blindness	18.46	14.39	38	28756	11985	29533748
Vomiting	18.43	14.39	126	28668	212134	29333599
Productive cough	18.33	14.39	4	28790	31255	29514478
Weight increased	18.26	14.39	29	28765	76638	29469095
Hypoxia	17.99	14.39	12	28782	47367	29498366
Glioblastoma multiforme	17.86	14.39	10	28784	667	29545066
Neutralising antibodies	17.81	14.39	3	28791	0	29545733
B-cell lymphoma stage I	17.81	14.39	3	28791	0	29545733
Diplopia	17.64	14.39	40	28754	13478	29532255
Anger	17.41	14.39	35	28759	10855	29534878
Nocturia	17.28	14.39	30	28764	8332	29537401
Oedema	17.14	14.39	9	28785	40474	29505259
No adverse event	16.78	14.39	46	28748	17432	29528301
Anal incontinence	16.73	14.39	26	28768	6589	29539144
Mood altered	16.63	14.39	29	28765	8082	29537651
Vaccination complication	16.62	14.39	5	28789	64	29545669
Depressed mood	16.50	14.39	44	28750	16404	29529329
Mood swings	16.29	14.39	27	28767	7224	29538509
Injection site dryness	16.28	14.39	4	28790	22	29545711
Therapeutic product effect incomplete	16.26	14.39	9	28785	39296	29506437
Peripheral swelling	16.26	14.39	23	28771	63716	29482017
Accident	16.25	14.39	19	28775	3669	29542064
Oxygen saturation decreased	16.25	14.39	12	28782	44925	29500808
Injection site pruritus	16.23	14.39	24	28770	5825	29539908
Drug intolerance	16.06	14.39	91	28703	48288	29497445
Back disorder	15.84	14.39	24	28770	5949	29539784
Cholelithiasis	15.84	14.39	47	28747	18625	29527108
Medical induction of coma	15.73	14.39	3	28791	3	29545730
Procedural pain	15.68	14.39	20	28774	4224	29541509
Vision blurred	15.67	14.39	79	28715	40097	29505636
Pneumonitis	15.63	14.39	4	28790	28040	29517693
Ophthalmoplegia	15.57	14.39	13	28781	1669	29544064
Appendicitis perforated	15.43	14.39	13	28781	1690	29544043
Somnolence	15.31	14.39	44	28750	93911	29451822
Prostate cancer stage II	15.07	14.39	9	28785	678	29545055
Umbilical cord around neck	15.03	14.39	6	28788	185	29545548
Brain neoplasm	14.97	14.39	16	28778	2800	29542933
Therapeutic response decreased	14.82	14.39	3	28791	24708	29521025
Scar	14.69	14.39	22	28772	5397	29540336
Magnetic resonance imaging head abnormal	14.68	14.39	11	28783	1208	29544525
Wheezing	14.66	14.39	7	28787	33233	29512500
Intentional product use issue	14.54	14.39	12	28782	42486	29503247
Renal surgery	14.52	14.39	3	28791	6	29545727
Fatigue	14.46	14.39	407	28387	316414	29229319
Haematuria	14.45	14.39	13	28781	44126	29501607
Feeling of body temperature change	14.40	14.39	11	28783	1243	29544490

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Multiple sclerosis relapse	8294.98	11.64	2939	101591	38196	64356006
Influenza like illness	4151.15	11.64	2014	102516	59688	64334514
Fall	932.93	11.64	2070	102460	414756	63979446
Gait disturbance	723.25	11.64	1123	103407	171032	64223170
General symptom	704.45	11.64	224	104306	2004	64392198
Breast cancer	667.15	11.64	474	104056	28674	64365528
Off label use	635.08	11.64	128	104402	632678	63761524
Urinary tract infection	511.37	11.64	1146	103384	230450	64163752
Central nervous system lesion	495.22	11.64	282	104248	11567	64382635
Memory impairment	488.75	11.64	647	103883	85035	64309167
Optic neuritis	479.09	11.64	243	104287	7873	64386329
Balance disorder	472.95	11.64	630	103900	83296	64310906
Toxicity to various agents	462.50	11.64	33	104497	363480	64030722
Injection site pain	455.10	11.64	718	103812	110690	64283512
Hypoaesthesia	449.19	11.64	807	103723	138301	64255901
Depression	436.12	11.64	935	103595	182356	64211846
Injection site erythema	416.67	11.64	543	103987	70257	64323945
Loss of control of legs	373.94	11.64	130	104400	1569	64392633
Drug interaction	365.03	11.64	72	104458	362011	64032191
Intervertebral disc protrusion	343.40	11.64	275	104255	19916	64374286
Acute kidney injury	341.12	11.64	151	104379	449089	63945113
Seizure	338.28	11.64	799	103731	166093	64228109
Gait inability	337.58	11.64	379	104151	41989	64352213
Diarrhoea	316.06	11.64	427	104103	722277	63671925
Muscular weakness	300.76	11.64	648	103882	126690	64267512
Secondary progressive multiple sclerosis	280.87	11.64	97	104433	1146	64393056
Muscle spasticity	262.31	11.64	217	104313	16452	64377750
Magnetic resonance imaging abnormal	258.71	11.64	118	104412	3005	64391197
Febrile neutropenia	257.02	11.64	11	104519	187646	64206556
Decubitus ulcer	246.39	11.64	191	104339	13188	64381014
Breast cancer female	244.78	11.64	133	104397	4970	64389232
Injection site bruising	244.11	11.64	298	104232	36075	64358127
Dyspnoea	242.34	11.64	502	104028	718172	63676030
Uterine leiomyoma	233.01	11.64	131	104399	5238	64388964
Stress	230.35	11.64	378	104152	60156	64334046
Neutropenia	224.43	11.64	56	104474	239568	64154634
Hysterectomy	215.08	11.64	122	104408	4963	64389239
Product use in unapproved indication	213.35	11.64	20	104510	176598	64217604
Road traffic accident	209.74	11.64	254	104276	30491	64363711
Injection site haemorrhage	205.10	11.64	224	104306	24054	64370148
Mobility decreased	203.89	11.64	438	104092	85402	64308800
Ankle fracture	203.81	11.64	178	104352	14532	64379670
Completed suicide	203.38	11.64	56	104474	224358	64169844
Trigeminal neuralgia	200.90	11.64	99	104431	3010	64391192
Rash	200.86	11.64	270	104260	458279	63935923
Progressive multiple sclerosis	198.96	11.64	67	104463	729	64393473
Product use issue	197.90	11.64	12	104518	151703	64242499
Injection site infection	195.01	11.64	83	104447	1782	64392420
Myocardial infarction	190.89	11.64	647	103883	165174	64229028
Injection site reaction	187.88	11.64	299	104231	46365	64347837
Injection site cellulitis	187.06	11.64	76	104454	1445	64392757
Coronary artery occlusion	186.27	11.64	165	104365	13726	64380476
Drug ineffective	181.07	11.64	726	103804	839521	63554681
Hypotension	180.67	11.64	211	104319	380763	64013439
Abortion spontaneous	175.22	11.64	210	104320	24933	64369269
Injection site abscess	169.01	11.64	69	104461	1329	64392873
Musculoskeletal disorder	168.57	11.64	175	104355	17731	64376471
Lower limb fracture	158.38	11.64	149	104381	13396	64380806
Malignant neoplasm progression	156.57	11.64	6	104524	112865	64281337
Muscle spasms	155.91	11.64	543	103987	140480	64253722
Drug abuse	154.62	11.64	17	104513	132357	64261845
Contraindicated product administered	152.12	11.64	5	104525	107824	64286378
Pancytopenia	151.74	11.64	25	104505	143284	64250918
Coordination abnormal	145.83	11.64	149	104381	14815	64379387
Thyroid cancer	143.02	11.64	86	104444	3905	64390297
Synovitis	141.94	11.64	4	104526	99086	64295116
Therapeutic product effect incomplete	141.85	11.64	6	104524	103476	64290726
Bladder disorder	141.09	11.64	110	104420	7657	64386545
Abdominal pain	140.63	11.64	180	104350	312195	64082007
Cystitis	139.29	11.64	249	104281	42426	64351776
Injection site haematoma	138.95	11.64	84	104446	3852	64390350
Hyponatraemia	138.16	11.64	35	104495	148304	64245898
Blood creatinine increased	136.59	11.64	27	104503	135755	64258447
Relapsing-remitting multiple sclerosis	135.02	11.64	55	104475	1053	64393149
Hyperkalaemia	134.94	11.64	7	104523	101122	64293080
Cognitive disorder	134.11	11.64	284	104246	54803	64339399
Peroneal nerve palsy	132.09	11.64	91	104439	5230	64388972
Anaemia	131.88	11.64	259	104271	378421	64015781
Chills	131.85	11.64	505	104025	136759	64257443
Cerebrovascular accident	131.20	11.64	505	104025	137078	64257124
Urinary incontinence	131.12	11.64	221	104309	35930	64358272
Infusion related reaction	129.78	11.64	52	104478	164415	64229787
Hip fracture	129.39	11.64	188	104342	26911	64367291
Injection site necrosis	128.78	11.64	56	104474	1269	64392933
Rheumatoid arthritis	124.73	11.64	55	104475	164239	64229963
Nausea	120.90	11.64	763	103767	785037	63609165
Thrombocytopenia	117.06	11.64	114	104416	223687	64170515
Post procedural complication	116.61	11.64	158	104372	21195	64373007
Breast cancer stage I	114.69	11.64	56	104474	1668	64392534
Cough	114.63	11.64	196	104334	301952	64092250
Stomatitis	114.07	11.64	20	104510	109585	64284617
Head injury	111.52	11.64	195	104335	32647	64361555
Adverse drug reaction	111.37	11.64	235	104295	45229	64348973
Caesarean section	111.21	11.64	113	104417	11161	64383041
Upper limb fracture	109.92	11.64	128	104402	14738	64379464
Multiple sclerosis	109.33	11.64	144	104386	18797	64375405
Breast cancer in situ	108.71	11.64	44	104486	828	64393374
Joint swelling	107.75	11.64	114	104416	215268	64178934
C-reactive protein increased	103.99	11.64	15	104515	94894	64299308
Injection site scar	102.77	11.64	40	104490	676	64393526
Amnesia	101.84	11.64	235	104295	48034	64346168
Interstitial lung disease	101.34	11.64	18	104512	97714	64296488
Neurogenic bladder	99.64	11.64	66	104464	3553	64390649
Dysstasia	99.32	11.64	153	104377	23062	64371140
Electrocardiogram QT prolonged	98.60	11.64	8	104522	79440	64314762
Migraine	97.63	11.64	272	104258	62405	64331797
Decreased appetite	97.32	11.64	193	104337	281096	64113106
Visual impairment	95.88	11.64	301	104229	73776	64320426
Peripheral swelling	94.59	11.64	120	104410	209033	64185169
Haemoglobin decreased	94.51	11.64	106	104424	194957	64199245
Diabetes mellitus	92.46	11.64	277	104253	66197	64328005
Pruritus	91.28	11.64	235	104295	312165	64082037
Drug hypersensitivity	90.40	11.64	154	104376	237661	64156541
Hypokalaemia	89.11	11.64	43	104487	121860	64272342
General physical health deterioration	87.63	11.64	122	104408	204303	64189899
Breast cancer stage II	87.21	11.64	44	104486	1408	64392794
Nephrolithiasis	87.06	11.64	208	104322	43475	64350727
Renal impairment	86.62	11.64	56	104474	134961	64259241
Asthenia	83.77	11.64	1060	103470	426984	63967218
Intentional product use issue	82.29	11.64	26	104504	95338	64298864
Hypoglycaemia	82.17	11.64	22	104508	89870	64304332
Procedural pain	82.03	11.64	113	104417	15395	64378807
Gastrointestinal haemorrhage	82.03	11.64	57	104473	132255	64261947
Pleural effusion	81.86	11.64	52	104478	126507	64267695
Paraesthesia	81.67	11.64	432	104098	134090	64260112
Mucosal inflammation	81.42	11.64	5	104525	62579	64331623
Metabolic acidosis	80.63	11.64	10	104520	70948	64323254
Ovarian cancer	80.59	11.64	56	104474	3263	64390939
Cholelithiasis	80.47	11.64	207	104323	45299	64348903
Platelet count decreased	80.29	11.64	92	104438	167619	64226583
Invasive ductal breast carcinoma	80.06	11.64	66	104464	4976	64389226
Multiple organ dysfunction syndrome	78.46	11.64	33	104497	101380	64292822
Intracranial aneurysm	78.16	11.64	57	104473	3586	64390616
Needle fatigue	77.91	11.64	31	104499	557	64393645
Blindness unilateral	76.42	11.64	73	104457	6688	64387514
Hemiparesis	76.34	11.64	157	104373	29670	64364532
Tachycardia	76.10	11.64	78	104452	149501	64244701
Tremor	76.06	11.64	455	104075	147775	64246427
Dyspnoea exertional	75.53	11.64	14	104516	73716	64320486
International normalised ratio increased	75.01	11.64	18	104512	79149	64315053
Respiratory failure	74.40	11.64	91	104439	161092	64233110
Neutrophil count decreased	74.23	11.64	17	104513	77179	64317023
Lactic acidosis	73.98	11.64	7	104523	61403	64332799
Malignant melanoma	73.96	11.64	98	104432	12866	64381336
Melaena	73.72	11.64	3	104527	53545	64340657
Neuromyelitis optica spectrum disorder	72.94	11.64	33	104497	824	64393378
Kidney infection	72.73	11.64	115	104415	17723	64376479
Therapeutic product effect decreased	72.43	11.64	49	104481	115302	64278900
Oxygen saturation decreased	72.15	11.64	42	104488	107134	64287068
Anxiety	71.86	11.64	568	103962	202081	64192121
Drug delivery device placement	71.66	11.64	22	104508	173	64394029
Glossodynia	71.39	11.64	10	104520	64686	64329516
Hypertension	70.31	11.64	685	103845	258576	64135626
Staphylococcal infection	70.30	11.64	211	104319	50467	64343735
Injection site mass	69.95	11.64	111	104419	17159	64377043
Gastric bypass	69.53	11.64	34	104496	1016	64393186
Gait spastic	68.56	11.64	32	104498	860	64393342
Lower respiratory tract infection	68.19	11.64	34	104496	94580	64299622
Oedema	67.84	11.64	32	104498	91903	64302299
Cardio-respiratory arrest	67.03	11.64	38	104492	98355	64295847
Intentional overdose	66.84	11.64	31	104499	89913	64304289
Sensory disturbance	66.52	11.64	94	104436	13114	64381088
Maternal exposure timing unspecified	66.49	11.64	46	104484	2661	64391541
Micturition urgency	66.46	11.64	83	104447	10276	64383926
Endometriosis	65.21	11.64	46	104484	2746	64391456
Cardiac failure	65.12	11.64	71	104459	132302	64261900
Concussion	64.88	11.64	72	104458	7866	64386336
Rhabdomyolysis	64.56	11.64	34	104496	91692	64302510
Injury associated with device	64.31	11.64	46	104484	2807	64391395
Treatment failure	63.98	11.64	57	104473	116759	64277443
Abdominal discomfort	63.95	11.64	124	104406	182198	64212004
Intentional product misuse	63.65	11.64	19	104511	72276	64321926
Hypoxia	63.04	11.64	32	104498	88117	64306085
Injection site induration	62.87	11.64	75	104455	8857	64385345
Overdose	62.76	11.64	101	104429	159465	64234737
Knee arthroplasty	60.89	11.64	135	104395	26864	64367338
Drug specific antibody present	58.92	11.64	56	104474	5098	64389104
Procedural anxiety	58.45	11.64	26	104504	623	64393579
Intervertebral disc degeneration	58.28	11.64	88	104442	13032	64381170
Appendicitis perforated	57.97	11.64	43	104487	2777	64391425
Productive cough	57.95	11.64	23	104507	73180	64321022
Lumbar spinal stenosis	57.93	11.64	53	104477	4597	64389605
Generalised tonic-clonic seizure	56.27	11.64	167	104363	39690	64354512
Intervertebral disc disorder	55.91	11.64	51	104479	4406	64389796
Septic shock	55.90	11.64	53	104477	105384	64288818
Speech disorder	55.62	11.64	189	104341	48252	64345950
Scar	55.49	11.64	87	104443	13311	64380891
Therapeutic response decreased	55.44	11.64	9	104521	52179	64342023
Bradycardia	55.33	11.64	66	104464	118153	64276049
Ligament rupture	55.14	11.64	40	104490	2496	64391706
Vomiting	54.88	11.64	600	103930	550517	63843685
Headache	54.82	11.64	1181	103349	528286	63865916
Bipolar disorder	54.70	11.64	61	104469	6700	64387502
Injection site ulcer	54.61	11.64	25	104505	642	64393560
Temperature intolerance	54.33	11.64	67	104463	8188	64386014
Influenza	53.98	11.64	326	104204	106205	64287997
Wheezing	53.63	11.64	32	104498	80547	64313655
Lung neoplasm malignant	52.67	11.64	111	104419	21337	64372865
Hypocalcaemia	52.37	11.64	4	104526	41749	64352453
Loss of personal independence in daily activities	52.26	11.64	26	104504	72428	64321774
Blood creatine phosphokinase increased	52.26	11.64	15	104515	58543	64335659
Appendicitis	51.93	11.64	85	104445	13484	64380718
Spinal stenosis	51.61	11.64	86	104444	13845	64380357
Intraductal proliferative breast lesion	51.54	11.64	36	104494	2115	64392087
Cervical spinal stenosis	51.07	11.64	35	104495	1994	64392208
Thrombosis	50.73	11.64	238	104292	70404	64323798
Injection site atrophy	50.38	11.64	20	104510	357	64393845
Somnolence	50.09	11.64	166	104364	203479	64190723
Paraparesis	49.76	11.64	43	104487	3459	64390743
Feeling abnormal	49.27	11.64	378	104152	133224	64260978
Hypomagnesaemia	48.57	11.64	3	104527	37373	64356829
Psoriasis	48.39	11.64	28	104502	71675	64322527
Meningioma benign	48.39	11.64	18	104512	267	64393935
Postoperative wound infection	48.31	11.64	71	104459	10265	64383937
Hip arthroplasty	47.30	11.64	106	104424	21245	64372957
Hospitalisation	47.13	11.64	32	104498	75175	64319027
Psoriatic arthropathy	47.03	11.64	7	104523	43274	64350928
Cervix carcinoma	46.80	11.64	32	104498	1816	64392386
Pregnancy	46.68	11.64	104	104426	20761	64373441
Ascites	46.64	11.64	21	104509	61980	64332222
Nerve compression	46.62	11.64	59	104471	7402	64386800
Surgery	46.47	11.64	125	104405	28088	64366114
Paralysis	46.24	11.64	74	104456	11521	64382681
Arthralgia	46.20	11.64	476	104054	441784	63952418
Dysgraphia	46.07	11.64	41	104489	3430	64390772
Serotonin syndrome	45.96	11.64	5	104525	39277	64354925
Tibia fracture	45.78	11.64	47	104483	4698	64389504
Pericarditis	45.75	11.64	22	104508	62494	64331708
Neuropathy peripheral	45.63	11.64	75	104455	117450	64276752
Depressed level of consciousness	45.48	11.64	39	104491	81397	64312805
Blood pressure systolic increased	45.38	11.64	12	104518	49441	64344761
Fatigue	45.18	11.64	1557	102973	747173	63647029
Lack of injection site rotation	45.15	11.64	18	104512	325	64393877
Erythema	44.29	11.64	155	104375	186915	64207287
Disease progression	44.12	11.64	103	104427	141577	64252625
Diplopia	43.49	11.64	118	104412	26647	64367555
Feeling cold	43.19	11.64	109	104421	23569	64370633
Basedow's disease	42.98	11.64	16	104514	238	64393964
Cytomegalovirus infection	42.85	11.64	5	104525	37194	64357008
Ataxia	42.75	11.64	104	104426	21980	64372222
Foot fracture	42.32	11.64	92	104438	18065	64376137
Neutralising antibodies positive	42.20	11.64	16	104514	251	64393951
Rash maculo-papular	42.05	11.64	12	104518	47014	64347188
Gallbladder disorder	41.66	11.64	88	104442	16942	64377260
Pain in extremity	41.54	11.64	706	103824	302379	64091823
Bone marrow failure	41.49	11.64	13	104517	47939	64346263
Pneumonitis	41.23	11.64	15	104515	50350	64343852
Injection site inflammation	40.69	11.64	37	104493	3184	64391018
Agitation	40.64	11.64	50	104480	88317	64305885
Injection site irritation	40.50	11.64	37	104493	3203	64390999
Primary progressive multiple sclerosis	40.43	11.64	12	104518	83	64394119
Pulmonary thrombosis	40.40	11.64	66	104464	10452	64383750
Muscle tightness	40.36	11.64	68	104462	11047	64383155
Mammoplasty	40.05	11.64	15	104515	227	64393975
Fibula fracture	40.04	11.64	36	104494	3052	64391150
Upper gastrointestinal haemorrhage	39.92	11.64	5	104525	35215	64358987
Hypervolaemia	39.79	11.64	7	104523	38278	64355924
Drug dependence	39.59	11.64	4	104526	33308	64360894
Injection site scab	39.34	11.64	16	104514	305	64393897
Haematochezia	39.29	11.64	30	104500	66343	64327859
Agraphia	39.28	11.64	10	104520	35	64394167
Nasal congestion	39.27	11.64	24	104506	59634	64334568
Constipation	39.11	11.64	215	104315	229122	64165080
Meniscus injury	38.97	11.64	48	104482	5859	64388343
Back disorder	38.80	11.64	63	104467	9927	64384275
Cholecystectomy	38.74	11.64	56	104474	7976	64386226
Papillary thyroid cancer	38.42	11.64	31	104499	2267	64391935
Sedation	38.16	11.64	10	104520	41452	64352750
Agranulocytosis	37.59	11.64	8	104522	38221	64355981
Haematuria	37.53	11.64	26	104504	60445	64333757
Breast cancer recurrent	37.28	11.64	32	104498	2551	64391651
Hypertonic bladder	36.92	11.64	36	104494	3382	64390820
Haemorrhage in pregnancy	36.84	11.64	24	104506	1256	64392946
Epistaxis	36.82	11.64	64	104466	98067	64296135
Vision blurred	36.39	11.64	261	104269	90055	64304147
Glioblastoma	36.29	11.64	25	104505	1436	64392766
Focal dyscognitive seizures	36.19	11.64	35	104495	3255	64390947
Osteoarthritis	36.10	11.64	200	104330	63136	64331066
Helicobacter infection	35.79	11.64	9	104521	38353	64355849
Appendicectomy	35.79	11.64	29	104501	2134	64392068
Cellulitis	35.65	11.64	267	104263	93390	64300812
Urosepsis	35.49	11.64	97	104433	21997	64372205
Blister	34.98	11.64	48	104482	80919	64313283
Rotator cuff syndrome	34.91	11.64	67	104463	12040	64382162
Meningioma	34.85	11.64	37	104493	3845	64390357
Colon cancer stage III	34.82	11.64	13	104517	195	64394007
Ruptured cerebral aneurysm	34.70	11.64	17	104513	510	64393692
Burning sensation	34.69	11.64	166	104364	49498	64344704
Medication error	34.45	11.64	19	104511	49947	64344255
Ovarian cyst	34.30	11.64	63	104467	10955	64383247
Retinal exudates	34.17	11.64	22	104508	1128	64393074
Delirium	34.14	11.64	37	104493	69157	64325045
Wound infection staphylococcal	34.11	11.64	32	104498	2865	64391337
Uterine cancer	34.11	11.64	32	104498	2866	64391336
Rectal haemorrhage	34.03	11.64	30	104500	61787	64332415
Shock	33.75	11.64	10	104520	38230	64355972
Brain neoplasm benign	33.70	11.64	12	104518	156	64394046
Thyroid disorder	32.86	11.64	64	104466	11628	64382574
Incorrect dose administered	32.84	11.64	30	104500	60735	64333467
Thyroid neoplasm	32.54	11.64	30	104500	2627	64391575
Ligament sprain	32.46	11.64	61	104469	10791	64383411
Endometrial cancer	32.43	11.64	26	104504	1884	64392318
No adverse event	32.40	11.64	111	104419	28450	64365752
Hepatic function abnormal	32.17	11.64	34	104496	64279	64329923
Hernia	32.08	11.64	69	104461	13449	64380753
Haemoptysis	31.91	11.64	20	104510	49028	64345174
Accidental exposure to product	31.77	11.64	3	104527	26361	64367841
Facial bones fracture	31.66	11.64	37	104493	4275	64389927
Malaise	31.55	11.64	853	103677	395394	63998808
Prolonged labour	31.51	11.64	15	104515	422	64393780
Breech presentation	31.48	11.64	17	104513	627	64393575
Mouth ulceration	31.48	11.64	7	104523	32437	64361765
Spinal fusion surgery	31.37	11.64	34	104496	3617	64390585
Tubulointerstitial nephritis	31.37	11.64	6	104524	30903	64363299
Arthritis	31.36	11.64	238	104292	83576	64310626
Colon cancer	31.36	11.64	66	104464	12673	64381529
Disseminated intravascular coagulation	31.34	11.64	7	104523	32341	64361861
Benign lung neoplasm	31.19	11.64	10	104520	92	64394110
Spinal disorder	31.19	11.64	53	104477	8669	64385533
Product administration error	31.14	11.64	4	104526	27639	64366563
Cholestasis	31.03	11.64	17	104513	44855	64349347
Band sensation	30.88	11.64	17	104513	652	64393550
Blindness	30.83	11.64	92	104438	21927	64372275
Mental impairment	30.61	11.64	76	104454	16267	64377935
Phobia	30.21	11.64	14	104516	370	64393832
Eosinophilia	30.07	11.64	12	104518	38064	64356138
Monoparesis	30.02	11.64	30	104500	2904	64391298
Movement disorder	29.94	11.64	91	104439	21909	64372293
Vein disorder	29.89	11.64	35	104495	4052	64390150
Procedural complication	29.84	11.64	47	104483	7218	64386984
Diplegia	29.66	11.64	23	104507	1588	64392614
JC polyomavirus test	29.66	11.64	8	104522	37	64394165
Dysarthria	29.57	11.64	181	104349	59225	64334977
Pollakiuria	29.40	11.64	115	104415	31415	64362787
Injection site nodule	29.38	11.64	31	104499	3199	64391003
Autoimmune hepatitis	29.32	11.64	56	104474	10028	64384174
Swelling	29.09	11.64	147	104383	160071	64234131
Acute respiratory failure	29.01	11.64	23	104507	49911	64344291
Suicidal ideation	28.98	11.64	196	104334	66346	64327856
Vertigo	28.87	11.64	179	104351	58832	64335370
Leukopenia	28.86	11.64	77	104453	101165	64293037
Skin laceration	28.67	11.64	96	104434	24321	64369881
Cellulitis staphylococcal	28.60	11.64	19	104511	1028	64393174
Product administered at inappropriate site	28.56	11.64	30	104500	3080	64391122
Frustration tolerance decreased	28.52	11.64	42	104488	6083	64388119
Gallbladder operation	28.50	11.64	23	104507	1682	64392520
Atrial fibrillation	28.28	11.64	162	104368	170927	64223275
Cardiac arrest	28.17	11.64	141	104389	153923	64240279
Product prescribing error	28.04	11.64	11	104519	35258	64358944
Rectocele	27.83	11.64	15	104515	551	64393651
Drug ineffective for unapproved indication	27.73	11.64	8	104522	31125	64363077
Wrist fracture	27.20	11.64	54	104476	9947	64384255
Rib fracture	26.89	11.64	93	104437	23945	64370257
Intervertebral disc operation	26.69	11.64	16	104514	722	64393480
Abnormal labour	26.69	11.64	6	104524	10	64394192
Cervical vertebral fracture	26.60	11.64	29	104501	3106	64391096
Cartilage injury	26.59	11.64	20	104510	1319	64392883
Hyperglycaemia	26.48	11.64	36	104494	60932	64333270
Chronic kidney disease	26.39	11.64	33	104497	57886	64336316
Hypercalcaemia	26.33	11.64	9	104521	31407	64362795
Folliculitis	26.30	11.64	8	104522	30069	64364133
Injection site discolouration	26.22	11.64	43	104487	6832	64387370
Blood urea increased	26.07	11.64	20	104510	44133	64350069
Product quality issue	25.92	11.64	8	104522	29791	64364411
Injection site injury	25.79	11.64	15	104515	640	64393562
Muscle atrophy	25.72	11.64	52	104478	9706	64384496
Paraplegia	25.70	11.64	34	104496	4456	64389746
Poor venous access	25.68	11.64	60	104470	12357	64381845
Dry skin	25.64	11.64	27	104503	51134	64343068
Sarcoidosis	25.58	11.64	40	104490	6106	64388096
Haemolytic uraemic syndrome	25.44	11.64	32	104498	3989	64390213
Chronic lymphocytic leukaemia	25.20	11.64	33	104497	4282	64389920
Abdominal distension	25.16	11.64	76	104454	95918	64298284
Clostridial infection	25.14	11.64	36	104494	5083	64389119
Volvulus	25.14	11.64	24	104506	2197	64392005
Oedema peripheral	25.04	11.64	219	104311	210098	64184104
Pulmonary sarcoidosis	24.95	11.64	18	104512	1113	64393089
Rash pruritic	24.83	11.64	34	104496	57370	64336832
Epilepsy	24.82	11.64	114	104416	33417	64360785
Blood potassium decreased	24.66	11.64	130	104400	40269	64353933
Obstructive airways disorder	24.62	11.64	4	104526	23181	64371021
Aphasia	24.54	11.64	131	104399	40775	64353427
Goitre	24.46	11.64	35	104495	4938	64389264
Decreased immune responsiveness	24.41	11.64	33	104497	4415	64389787
Central venous catheterisation	24.39	11.64	26	104504	2715	64391487
Depressed mood	24.37	11.64	131	104399	40881	64353321
Oestrogen receptor assay positive	24.30	11.64	11	104519	275	64393927
Varicose vein	24.26	11.64	30	104500	3677	64390525
Arterial occlusive disease	24.18	11.64	42	104488	6991	64387211
Orthostatic hypotension	24.18	11.64	24	104506	46714	64347488
Fluid retention	24.11	11.64	37	104493	59569	64334633
Drug intolerance	24.08	11.64	192	104338	187800	64206402
Autoimmune thyroiditis	23.81	11.64	29	104501	3499	64390703
Benign breast neoplasm	23.80	11.64	15	104515	741	64393461
Systemic lupus erythematosus	23.69	11.64	57	104473	77555	64316647
Stevens-Johnson syndrome	23.64	11.64	13	104517	34236	64359966
Brain neoplasm	23.51	11.64	34	104496	4844	64389358
Angioedema	23.48	11.64	40	104490	61781	64332421
Myoclonus	23.23	11.64	6	104524	25112	64369090
Muscle injury	23.17	11.64	7	104523	26430	64367772
Renal tubular necrosis	23.07	11.64	4	104526	22106	64372096
Progesterone receptor assay positive	22.98	11.64	10	104520	227	64393975
Withdrawal syndrome	22.93	11.64	5	104525	23487	64370715
Breast calcifications	22.85	11.64	15	104515	795	64393407
Fractured coccyx	22.76	11.64	16	104514	950	64393252
Anal incontinence	22.72	11.64	65	104465	15131	64379071
Thermal burn	22.60	11.64	37	104493	5869	64388333
Hepatocellular injury	22.52	11.64	24	104506	45211	64348991
Cervical dysplasia	22.44	11.64	21	104509	1875	64392327
Bladder dysfunction	22.40	11.64	16	104514	974	64393228
Post procedural stroke	22.40	11.64	8	104522	105	64394097
Pulmonary oedema	22.30	11.64	60	104470	78614	64315588
Haematemesis	22.24	11.64	26	104504	46973	64347229
COVID-19	22.22	11.64	45	104485	65095	64329107
Right ventricular failure	22.15	11.64	4	104526	21467	64372735
Anaphylactic reaction	22.11	11.64	49	104481	68615	64325587
Skull fracture	22.05	11.64	19	104511	1522	64392680
Blood calcium decreased	21.98	11.64	7	104523	25547	64368655
Mental disorder	21.92	11.64	93	104437	26352	64367850
Ectopic pregnancy	21.81	11.64	19	104511	1545	64392657
Overweight	21.77	11.64	27	104503	3319	64390883
Osteonecrosis	21.66	11.64	97	104433	28132	64366070
Colostomy closure	21.64	11.64	9	104521	182	64394020
Neuralgia	21.64	11.64	92	104438	26092	64368110
Crohn's disease	21.58	11.64	21	104509	1968	64392234
Blood cholesterol increased	21.52	11.64	147	104383	49919	64344283
Alopecia	21.32	11.64	169	104361	165521	64228681
Blood pressure diastolic decreased	21.26	11.64	5	104525	22296	64371906
Back injury	21.24	11.64	42	104488	7715	64386487
Blood pressure fluctuation	21.17	11.64	32	104498	51839	64342363
Retinal tear	21.14	11.64	17	104513	1237	64392965
Restlessness	21.08	11.64	20	104510	39765	64354437
Vaccination complication	21.06	11.64	13	104517	619	64393583
Bronchopulmonary aspergillosis	20.94	11.64	3	104527	19082	64375120
Ventricular tachycardia	20.91	11.64	15	104515	34250	64359952
Urinary tract infection staphylococcal	20.87	11.64	14	104516	770	64393432
Pelvic fracture	20.72	11.64	50	104480	10513	64383689
Spondylolisthesis	20.56	11.64	24	104506	2770	64391432
Female genital operation	20.48	11.64	5	104525	14	64394188
Rectal cancer	20.47	11.64	24	104506	2782	64391420
Renal cell carcinoma	20.40	11.64	36	104494	6068	64388134
Reaction to preservatives	20.30	11.64	8	104522	140	64394062
Cephalo-pelvic disproportion	20.04	11.64	8	104522	145	64394057
Enterocele	20.03	11.64	6	104524	43	64394159
Abortion missed	20.00	11.64	16	104514	1156	64393046
Tachypnoea	19.98	11.64	9	104521	26562	64367640
Intervertebral disc displacement	19.95	11.64	11	104519	423	64393779
Fear of injection	19.93	11.64	35	104495	5877	64388325
Magnetic resonance imaging head abnormal	19.92	11.64	22	104508	2390	64391812
Lumbar radiculopathy	19.91	11.64	19	104511	1738	64392464
Polyneuropathy	19.90	11.64	4	104526	19890	64374312
Pre-eclampsia	19.86	11.64	36	104494	6195	64388007
Breast cancer stage III	19.80	11.64	24	104506	2881	64391321
Encephalopathy	19.75	11.64	41	104489	58778	64335424
Carotid artery aneurysm	19.70	11.64	9	104521	230	64393972
Myelosuppression	19.67	11.64	7	104523	23823	64370379
Oral pain	19.62	11.64	10	104520	27483	64366719
Ophthalmoplegia	19.53	11.64	23	104507	2679	64391523
Incision site complication	19.51	11.64	13	104517	707	64393495
Benign neoplasm of spinal cord	19.47	11.64	4	104526	3	64394199
Rectal cancer stage I	19.47	11.64	4	104526	3	64394199
Cholecystitis	19.44	11.64	73	104457	19563	64374639
Clavicle fracture	19.35	11.64	27	104503	3722	64390480
Incision site abscess	19.31	11.64	9	104521	241	64393961
Medical induction of coma	19.25	11.64	7	104523	97	64394105
Spinal osteoarthritis	19.21	11.64	59	104471	14282	64379920
Scoliosis	19.21	11.64	35	104495	6047	64388155
Nerve injury	19.13	11.64	40	104490	7645	64386557
Foetal heart rate abnormal	19.11	11.64	9	104521	247	64393955
Fibrocystic breast disease	19.09	11.64	12	104518	590	64393612
Throat irritation	19.08	11.64	15	104515	32696	64361506
Limb mass	19.05	11.64	24	104506	2997	64391205
Expanded disability status scale score increased	19.05	11.64	11	104519	463	64393739
Malignant hypertension	19.01	11.64	17	104513	1431	64392771
Limb injury	18.97	11.64	82	104448	23423	64370779
Oral candidiasis	18.85	11.64	7	104523	23205	64370997
Oropharyngeal pain	18.83	11.64	77	104453	88790	64305412
Cardiogenic shock	18.75	11.64	15	104515	32412	64361790
Death	18.74	11.64	618	103912	482087	63912115
Lung carcinoma cell type unspecified stage IV	18.71	11.64	14	104516	916	64393286
Accident	18.66	11.64	37	104493	6809	64387393
Fat necrosis	18.64	11.64	13	104517	762	64393440
Atrophy	18.60	11.64	19	104511	1888	64392314
Urinary bladder suspension	18.57	11.64	7	104523	108	64394094
Schwannoma	18.51	11.64	7	104523	109	64394093
Panic attack	18.39	11.64	75	104455	20878	64373324
Heavy menstrual bleeding	18.39	11.64	52	104478	12025	64382177
Conversion disorder	18.37	11.64	18	104512	1701	64392501
Post procedural infection	18.37	11.64	45	104485	9552	64384650
Cholecystitis infective	18.35	11.64	22	104508	2611	64391591
Bladder prolapse	18.25	11.64	15	104515	1126	64393076
Glioblastoma multiforme	18.22	11.64	15	104515	1129	64393073
Therapy non-responder	18.12	11.64	51	104479	65848	64328354
Knee operation	18.05	11.64	29	104501	4528	64389674
Cardiac valve rupture	18.05	11.64	4	104526	6	64394196
Full blood count decreased	18.02	11.64	7	104523	22575	64371627
Respiratory distress	17.97	11.64	36	104494	52295	64341907
Hepatotoxicity	17.96	11.64	23	104507	39939	64354263
Loss of consciousness	17.94	11.64	339	104191	148026	64246176
Altered state of consciousness	17.89	11.64	21	104509	37881	64356321
Precancerous cells present	17.80	11.64	14	104516	987	64393215
Pain in jaw	17.76	11.64	24	104506	40731	64353471
Patella fracture	17.76	11.64	17	104513	1561	64392641
Injection site calcification	17.74	11.64	5	104525	28	64394174
Inappropriate antidiuretic hormone secretion	17.64	11.64	7	104523	22282	64371920
Femur fracture	17.62	11.64	105	104425	34030	64360172
Inflammation	17.61	11.64	51	104479	65249	64328953
Raynaud's phenomenon	17.61	11.64	14	104516	1002	64393200
Uterine disorder	17.53	11.64	18	104512	1799	64392403
Demyelination	17.52	11.64	36	104494	6798	64387404
Breast cancer metastatic	17.48	11.64	37	104493	7132	64387070
Red blood cell sedimentation rate increased	17.38	11.64	15	104515	31220	64362982
Hallucination, visual	17.22	11.64	12	104518	27822	64366380
Rash erythematous	17.10	11.64	33	104497	48600	64345602
Toxic skin eruption	17.09	11.64	5	104525	19279	64374923
Urinary retention postoperative	17.09	11.64	7	104523	136	64394066
Skin exfoliation	17.08	11.64	29	104501	44856	64349346
Gun shot wound	17.04	11.64	14	104516	1050	64393152
Product substitution issue	17.03	11.64	4	104526	17857	64376345
Heat stroke	17.00	11.64	16	104514	1439	64392763
Injection site swelling	16.93	11.64	120	104410	41233	64352969
Female sterilisation	16.90	11.64	8	104522	222	64393980
Contusion	16.87	11.64	269	104261	113696	64280506
Progressive relapsing multiple sclerosis	16.79	11.64	5	104525	35	64394167
Ovarian germ cell teratoma benign	16.79	11.64	5	104525	35	64394167
Fear	16.77	11.64	71	104459	20100	64374102
Skin cancer	16.73	11.64	50	104480	11924	64382278
Injection site fibrosis	16.71	11.64	4	104526	10	64394192
Colon cancer metastatic	16.68	11.64	18	104512	1905	64392297
Haemophagocytic lymphohistiocytosis	16.68	11.64	4	104526	17605	64376597
Circulatory collapse	16.68	11.64	18	104512	33714	64360488
Anuria	16.66	11.64	5	104525	18959	64375243
Intervertebral disc injury	16.63	11.64	7	104523	146	64394056
Hand fracture	16.62	11.64	29	104501	4845	64389357
Optic nerve disorder	16.58	11.64	14	104516	1091	64393111
Aggression	16.58	11.64	31	104499	46201	64348001
Skin graft	16.54	11.64	13	104517	915	64393287
Dystonia	16.52	11.64	5	104525	18860	64375342
Post procedural haemorrhage	16.52	11.64	51	104479	12380	64381822
Endometrial adenocarcinoma	16.49	11.64	13	104517	919	64393283
Complication of delivery	16.45	11.64	6	104524	84	64394118
Uterine leiomyosarcoma	16.44	11.64	4	104526	11	64394191
Weight increased	16.41	11.64	245	104285	213103	64181099
Motor dysfunction	16.38	11.64	48	104482	11325	64382877
Renal failure	16.37	11.64	202	104328	181486	64212716
Heat exhaustion	16.33	11.64	8	104522	240	64393962
Endometrial cancer stage I	16.33	11.64	7	104523	153	64394049
Adrenal insufficiency	16.32	11.64	8	104522	22479	64371723
Benign uterine neoplasm	16.28	11.64	3	104527	0	64394202
Alpha-1 anti-trypsin increased	16.28	11.64	3	104527	0	64394202
Neurological complication associated with device	16.28	11.64	3	104527	0	64394202
Biopsy bladder	16.28	11.64	3	104527	0	64394202
Non-small cell lung cancer stage I	16.18	11.64	4	104526	12	64394190
Purpura	16.18	11.64	4	104526	17242	64376960
Lipoatrophy	15.94	11.64	11	104519	634	64393568
Arthroscopy	15.92	11.64	10	104520	491	64393711
Transaminases increased	15.90	11.64	30	104500	44564	64349638
Hyperthermia	15.82	11.64	3	104527	15547	64378655
Febrile convulsion	15.80	11.64	12	104518	803	64393399
Gastric cyst	15.77	11.64	6	104524	95	64394107
Insomnia	15.73	11.64	426	104104	197410	64196792
Serum serotonin decreased	15.71	11.64	4	104526	14	64394188
Dry mouth	15.71	11.64	48	104482	60370	64333832
Ovarian cancer stage III	15.69	11.64	7	104523	169	64394033
Myelodysplastic syndrome	15.65	11.64	13	104517	27566	64366636
Dysgeusia	15.62	11.64	33	104497	47014	64347188
Feeling of body temperature change	15.58	11.64	28	104502	4786	64389416
Coronary artery disease	15.52	11.64	158	104372	60275	64333927
Amniotic fluid volume decreased	15.49	11.64	8	104522	269	64393933
Neoplasm malignant	15.45	11.64	80	104450	24608	64369594
Calculus bladder	15.38	11.64	14	104516	1206	64392996
Rales	15.36	11.64	3	104527	15226	64378976
Eye disorder	15.36	11.64	66	104464	18803	64375399
Sinus bradycardia	15.36	11.64	9	104521	22884	64371318
Rhinorrhoea	15.34	11.64	48	104482	59921	64334281
Paraganglion neoplasm	15.29	11.64	4	104526	16	64394186
Oophorectomy bilateral	15.29	11.64	4	104526	16	64394186
Emotional disorder	15.18	11.64	50	104480	12557	64381645
Ventricular fibrillation	15.15	11.64	10	104520	23850	64370352
Wound	15.14	11.64	68	104462	76409	64317793
Cast application	15.10	11.64	4	104526	17	64394185
Injection site hypoaesthesia	15.06	11.64	9	104521	404	64393798
Reproductive tract disorder	15.05	11.64	5	104525	52	64394150
JC polyomavirus test positive	14.98	11.64	14	104516	1248	64392954
Dyspepsia	14.96	11.64	73	104457	80239	64313963
Lyme disease	14.93	11.64	19	104511	2396	64391806
Myopathy	14.93	11.64	5	104525	17675	64376527
Hypoalbuminaemia	14.92	11.64	5	104525	17669	64376533
Face oedema	14.90	11.64	11	104519	24750	64369452
Animal bite	14.85	11.64	18	104512	2161	64392041
Blood bilirubin increased	14.77	11.64	46	104484	57507	64336695
Faeces discoloured	14.76	11.64	12	104518	25717	64368485
Hyperbilirubinaemia	14.71	11.64	8	104522	21197	64373005
Nephropathy toxic	14.71	11.64	5	104525	17509	64376693
Spinal fracture	14.68	11.64	56	104474	15118	64379084
Confusional state	14.67	11.64	317	104213	260827	64133375
Crying	14.64	11.64	68	104462	20022	64374180
Incontinence	14.63	11.64	48	104482	12033	64382169
Meningitis viral	14.61	11.64	16	104514	1722	64392480
Benign renal neoplasm	14.57	11.64	4	104526	20	64394182
Umbilical cord around neck	14.57	11.64	4	104526	20	64394182
Ovarian adenoma	14.51	11.64	7	104523	203	64393999
Neurofibroma	14.41	11.64	4	104526	21	64394181
Medical device removal	14.39	11.64	10	104520	583	64393619
Colon cancer stage I	14.33	11.64	5	104525	61	64394141
Joint dislocation	14.28	11.64	46	104484	11419	64382783
Cystitis pseudomonal	14.21	11.64	3	104527	3	64394199
Lhermitte's sign	14.21	11.64	3	104527	3	64394199
Glomerular filtration rate decreased	14.15	11.64	7	104523	19565	64374637
Uterine mass	14.14	11.64	7	104523	215	64393987
Staphylococcal abscess	14.10	11.64	12	104518	945	64393257
Injection site thrombosis	14.09	11.64	6	104524	129	64394073
Drug eruption	14.07	11.64	23	104507	36113	64358089
Postoperative thrombosis	14.00	11.64	6	104524	131	64394071
Anaesthetic complication	13.95	11.64	19	104511	2560	64391642
Drug delivery system malfunction	13.90	11.64	9	104521	466	64393736
Hepatic steatosis	13.90	11.64	92	104438	30915	64363287
Arnold-Chiari malformation	13.88	11.64	6	104524	134	64394068
Abdominal operation	13.87	11.64	9	104521	468	64393734
Eosinophil count increased	13.78	11.64	3	104527	14109	64380093
Shock haemorrhagic	13.74	11.64	5	104525	16786	64377416
B-cell lymphoma stage I	13.74	11.64	3	104527	4	64394198
Liver function test increased	13.74	11.64	18	104512	30952	64363250
Spinal cord disorder	13.72	11.64	15	104515	1611	64392591
Neutralising antibodies	13.69	11.64	4	104526	26	64394176
Transfusion	13.68	11.64	6	104524	17988	64376214
Intestinal cyst	13.68	11.64	6	104524	139	64394063
Bladder cancer	13.65	11.64	44	104486	10930	64383272
Intracranial hypotension	13.61	11.64	8	104522	348	64393854
Ocular hyperaemia	13.61	11.64	10	104520	22554	64371648
Superficial vein prominence	13.45	11.64	5	104525	74	64394128
Limb traumatic amputation	13.43	11.64	4	104526	28	64394174
Cardiac disorder	13.42	11.64	144	104386	55672	64338530
Anti-interferon antibody positive	13.35	11.64	3	104527	5	64394197
Wrong technique in product usage process	13.33	11.64	57	104473	64917	64329285
Cervical incompetence	13.29	11.64	9	104521	503	64393699
Viral pericarditis	13.27	11.64	5	104525	77	64394125
Aspergillus infection	13.20	11.64	5	104525	16374	64377828
Viral infection	13.16	11.64	102	104428	36038	64358164
Plasma cell myeloma	13.16	11.64	35	104495	46040	64348162
Cardiac failure acute	13.15	11.64	5	104525	16339	64377863
Optic atrophy	13.15	11.64	15	104515	1688	64392514
Hepatic encephalopathy	13.14	11.64	9	104521	21057	64373145
Abdominal pain upper	13.11	11.64	202	104328	174828	64219374
Ovarian cyst ruptured	13.11	11.64	11	104519	850	64393352
Transient ischaemic attack	13.06	11.64	119	104411	44063	64350139
Lung adenocarcinoma	13.03	11.64	32	104498	6801	64387401
Haemodynamic instability	12.97	11.64	4	104526	14908	64379294
Lung adenocarcinoma stage I	12.86	11.64	4	104526	33	64394169
Acute hepatic failure	12.84	11.64	14	104516	26098	64368104
Cystocele	12.79	11.64	10	104520	699	64393503
Invasive lobular breast carcinoma	12.78	11.64	9	104521	536	64393666
Fasciitis	12.76	11.64	10	104520	701	64393501
Dry eye	12.74	11.64	17	104513	29002	64365200
Chronic leukaemia	12.68	11.64	3	104527	7	64394195
Bipolar I disorder	12.68	11.64	15	104515	1756	64392446
Porphyria non-acute	12.64	11.64	10	104520	711	64393491
Lung disorder	12.60	11.64	53	104477	60647	64333555
Diabetic ketoacidosis	12.58	11.64	18	104512	29827	64364375
Liposarcoma	12.51	11.64	7	104523	277	64393925
Rubber sensitivity	12.50	11.64	13	104517	1319	64392883
Lung cancer metastatic	12.46	11.64	20	104510	3120	64391082
Eczema	12.45	11.64	18	104512	29702	64364500
Impaired self-care	12.45	11.64	17	104513	2296	64391906
Spinal laminectomy	12.44	11.64	9	104521	559	64393643
Blood alkaline phosphatase increased	12.40	11.64	48	104482	56231	64337971
Inappropriate schedule of product administration	12.39	11.64	93	104437	92193	64302009
Cystitis interstitial	12.37	11.64	12	104518	1120	64393082
Arterial therapeutic procedure	12.36	11.64	4	104526	38	64394164
Allergy to metals	12.34	11.64	8	104522	415	64393787
Urinary tract disorder	12.34	11.64	20	104510	3146	64391056
Central nervous system inflammation	12.34	11.64	6	104524	177	64394025
Hyperaesthesia	12.32	11.64	40	104490	9974	64384228
Erythema multiforme	12.31	11.64	5	104525	15696	64378506
Maternal exposure during pregnancy	12.25	11.64	221	104309	95663	64298539
Umbilical hernia	12.24	11.64	24	104506	4381	64389821
Ovarian neoplasm	12.23	11.64	9	104521	574	64393628
Gastric banding	12.09	11.64	4	104526	41	64394161
Immunology test abnormal	12.09	11.64	4	104526	41	64394161
Myelitis transverse	12.04	11.64	14	104516	1609	64392593
Hypovolaemia	12.03	11.64	5	104525	15481	64378721
Blood lactate dehydrogenase increased	12.02	11.64	22	104508	33056	64361146
Uterine cyst	12.01	11.64	7	104523	300	64393902
Renal surgery	12.01	11.64	4	104526	42	64394160
Cold type haemolytic anaemia	11.96	11.64	7	104523	302	64393900
Sensory loss	11.95	11.64	40	104490	10129	64384073
Liver function test abnormal	11.93	11.64	148	104382	59253	64334949
Ulcer haemorrhage	11.91	11.64	24	104506	4468	64389734
Colon cancer stage II	11.85	11.64	5	104525	105	64394097
Visual acuity reduced	11.85	11.64	80	104450	27061	64367141
Central nervous system infection	11.83	11.64	12	104518	1182	64393020
Breast cellulitis	11.80	11.64	7	104523	310	64393892
Premature labour	11.79	11.64	33	104497	7587	64386615
Basal cell carcinoma	11.77	11.64	88	104442	30750	64363452
Urine output decreased	11.77	11.64	6	104524	16486	64377716
Complication of pregnancy	11.76	11.64	7	104523	312	64393890
Aneurysm	11.75	11.64	19	104511	2983	64391219
Cerebral thrombosis	11.69	11.64	16	104514	2166	64392036
Prostate cancer stage II	11.69	11.64	9	104521	615	64393587
Lung infiltration	11.66	11.64	10	104520	20879	64373323
Partial seizures	11.65	11.64	32	104498	7275	64386927
Hemianaesthesia	11.65	11.64	8	104522	457	64393745

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	L03AB07	ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS IMMUNOSTIMULANTS IMMUNOSTIMULANTS Interferons
FDA CS	M0025715	Interferon-beta
MeSH PA	D000276	Adjuvants, Immunologic
MeSH PA	D000890	Anti-Infective Agents
MeSH PA	D000970	Antineoplastic Agents
MeSH PA	D000998	Antiviral Agents
MeSH PA	D007155	Immunologic Factors
FDA EPC	N0000191625	Interferon beta

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Relapsing remitting multiple sclerosis	indication	426373005	DOID:2378

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Interferon alpha/beta receptor	Membrane receptor	P17181 P48551	INAR1_HUMAN INAR2_HUMAN	AGONIST				DRUG LABEL	DRUG LABEL

External reference:

ID	Source
XRO4566Q4R	UNII
4024025	VANDF
C0254119	UMLSCUI
CHEMBL1201562	ChEMBL_ID
D04554	KEGG_DRUG
DB00060	DRUGBANK_ID
CHEMBL2108510	ChEMBL_ID
D000068556	MESH_DESCRIPTOR_UI
153326	RXNORM
4895	MMSL
6144	MMSL
d04011	MMSL
108749003	SNOMEDCT_US
386902004	SNOMEDCT_US
005910	NDDF

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
REBIF	HUMAN PRESCRIPTION DRUG LABEL	1	44087-0022	INJECTION, SOLUTION	22 ug	SUBCUTANEOUS	BLA	30 sections
REBIF	HUMAN PRESCRIPTION DRUG LABEL	1	44087-0044	INJECTION, SOLUTION	44 ug	SUBCUTANEOUS	BLA	30 sections
REBIF REBIDOSE	HUMAN PRESCRIPTION DRUG LABEL	1	44087-3322	INJECTION, SOLUTION	22 ug	SUBCUTANEOUS	BLA	30 sections
REBIF REBIDOSE	HUMAN PRESCRIPTION DRUG LABEL	1	44087-3344	INJECTION, SOLUTION	44 ug	SUBCUTANEOUS	BLA	30 sections
Avonex	HUMAN PRESCRIPTION DRUG LABEL	1	59627-002	INJECTION, SOLUTION	30 ug	INTRAMUSCULAR	BLA	28 sections
Avonex Pen	HUMAN PRESCRIPTION DRUG LABEL	1	59627-003	INJECTION, SOLUTION	30 ug	INTRAMUSCULAR	BLA	28 sections