All FDA-approved EMA-approved PMDA-approved
Target Card Uniprot Example: P23975

interferon beta-1a 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	5139	145258-61-3

Description:

Molecule

Description

Synonyms: interferon beta-1a avonex

An interferon beta-1 subtype that has a methionine at position 1, a cysteine at position 17, and is glycosylated at position 80. It functions as an ANTI-VIRAL AGENT and IMMUNOMODULATOR and is used to manage the symptoms of RELAPSING-REMITTING MULTIPLE SCLEROSIS. A possible role for IFNs in prophylaxis or early treatment of COVID-19 has been suggested to compensate for possibly insufficient endogenous IFN production. However, the efficacy and safety of IFNs for treatment or prevention of COVID-19 were not established. Molecular weight: Formula: CLOGP: LIPINSKI: None HAC: None HDO: None TPSA: ALOGS: ROTB: None

Drug dosage:

Dose	Unit	Route
4.30	mcg	P

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
March 13, 1997	EMA	Biogen Netherlands B.V.
May 17, 1996	FDA	BIOGEN

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Multiple sclerosis relapse	8943.40	11.63	3404	120066	45074	63320478
Influenza like illness	4896.71	11.63	2450	121020	64374	63301178
Fall	930.25	11.63	2227	121243	390107	62975445
General symptom	903.66	11.63	299	123171	2509	63363043
Injection site erythema	883.74	11.63	943	122527	82231	63283321
Off label use	848.47	11.63	147	123323	674315	62691237
Optic neuritis	812.32	11.63	374	123096	8061	63357491
Central nervous system lesion	767.81	11.63	387	123083	10248	63355304
Breast cancer	758.42	11.63	679	122791	47704	63317848
Gait disturbance	747.97	11.63	1304	122166	181874	63183678
Injection site pain	733.44	11.63	1072	122398	128728	63236824
Depression	623.79	11.63	1256	122214	195236	63170316
Memory impairment	551.27	11.63	835	122635	103423	63262129
Balance disorder	532.20	11.63	735	122735	83687	63281865
Seizure	470.58	11.63	889	122581	131745	63233807
Urinary tract infection	469.25	11.63	1350	122120	263334	63102218
Hypoaesthesia	468.28	11.63	1020	122450	167373	63198179
Injection site bruising	419.88	11.63	461	123009	41449	63324103
Contraindicated product administered	380.31	11.63	9	123461	217639	63147913
Diarrhoea	376.64	11.63	506	122964	714860	62650692
Loss of control of legs	375.72	11.63	130	123340	1266	63364286
Product use issue	367.65	11.63	14	123456	220506	63145046
Magnetic resonance imaging abnormal	348.62	11.63	153	123317	2932	63362620
Rash	345.15	11.63	350	123120	560521	62805031
Toxicity to various agents	344.66	11.63	39	123431	247211	63118341
Muscular weakness	344.29	11.63	745	122725	121608	63243944
Synovitis	341.99	11.63	4	123466	186914	63178638
Secondary progressive multiple sclerosis	323.58	11.63	117	123353	1310	63364242
Infusion related reaction	315.39	11.63	50	123420	245471	63120081
Injection site haematoma	305.13	11.63	181	123289	6651	63358901
Intervertebral disc protrusion	304.47	11.63	298	123172	23411	63342141
Joint swelling	301.63	11.63	130	123340	327536	63038016
Product use in unapproved indication	299.72	11.63	11	123459	179069	63186483
Glossodynia	286.16	11.63	15	123455	178861	63186691
Drug ineffective	283.36	11.63	1064	122406	1043701	62321851
Injection site reaction	278.76	11.63	447	123023	58077	63307475
Stress	269.33	11.63	475	122995	66692	63298860
Gait inability	265.35	11.63	414	123056	52545	63313007
Rheumatoid arthritis	261.54	11.63	84	123386	253735	63111817
Cognitive disorder	254.53	11.63	418	123052	55397	63310155
Dyspnoea	254.36	11.63	570	122900	660743	62704809
Uterine leiomyoma	251.28	11.63	179	123291	9019	63356533
Abdominal discomfort	249.89	11.63	158	123312	320727	63044825
Injection site haemorrhage	246.15	11.63	269	123201	24045	63341507
Abortion spontaneous	236.51	11.63	369	123101	46826	63318726
Chills	223.73	11.63	602	122868	112776	63252776
Decubitus ulcer	223.32	11.63	176	123294	10344	63355208
Drug interaction	221.97	11.63	84	123386	229047	63136505
Needle fatigue	220.70	11.63	51	123419	77	63365475
Injection site scar	217.93	11.63	80	123390	938	63364614
Hysterectomy	212.66	11.63	164	123306	9335	63356217
Ankle fracture	211.85	11.63	215	123255	17640	63347912
Peripheral swelling	205.53	11.63	132	123338	265810	63099742
Injection site necrosis	203.21	11.63	82	123388	1262	63364290
Trigeminal neuralgia	202.38	11.63	110	123360	3409	63362143
Muscle spasticity	193.12	11.63	225	123245	21569	63343983
Systemic lupus erythematosus	188.74	11.63	85	123385	208833	63156719
Neutropenia	185.43	11.63	55	123415	174950	63190602
Completed suicide	183.97	11.63	31	123439	145642	63219910
Febrile neutropenia	183.09	11.63	12	123458	118437	63247115
Pericarditis	182.61	11.63	21	123449	131558	63233994
Myocardial infarction	181.78	11.63	515	122955	99378	63266174
Peroneal nerve palsy	179.90	11.63	114	123356	4721	63360831
Drug hypersensitivity	179.36	11.63	204	123266	310483	63055069
Breast cancer female	178.89	11.63	173	123297	13386	63352166
Coronary artery occlusion	178.11	11.63	139	123331	8052	63357500
Urinary incontinence	176.93	11.63	262	123208	31752	63333800
Musculoskeletal disorder	176.07	11.63	209	123261	20435	63345117
Injection site infection	174.15	11.63	82	123388	1861	63363691
Stomatitis	174.13	11.63	30	123440	138695	63226857
Therapeutic product effect decreased	173.87	11.63	79	123391	193108	63172444
Acute kidney injury	172.50	11.63	155	123315	263260	63102292
Nausea	168.81	11.63	975	122495	853496	62512056
Intentional product use issue	166.48	11.63	25	123445	127867	63237685
Arthralgia	166.38	11.63	561	122909	569149	62796403
Cerebrovascular accident	165.42	11.63	524	122946	107500	63258052
Injection site abscess	163.76	11.63	68	123402	1130	63364422
Abdominal pain	162.60	11.63	199	123271	293257	63072295
Alopecia	158.14	11.63	258	123212	337278	63028274
Bladder disorder	154.98	11.63	133	123337	8813	63356739
Swelling	153.34	11.63	186	123284	275192	63090360
Therapeutic product effect incomplete	152.72	11.63	29	123441	125027	63240525
Diabetes mellitus	152.44	11.63	336	123134	55474	63310078
Injection site mass	146.27	11.63	181	123289	18475	63347077
Coordination abnormal	145.73	11.63	156	123314	13617	63351935
Injection site cellulitis	144.31	11.63	63	123407	1191	63364361
Caesarean section	142.89	11.63	171	123299	16861	63348691
Neuromyelitis optica spectrum disorder	142.38	11.63	59	123411	975	63364577
Helicobacter infection	141.63	11.63	10	123460	92775	63272777
Lower respiratory tract infection	141.19	11.63	41	123429	132266	63233286
Abortion	137.94	11.63	76	123394	2420	63363132
Malignant neoplasm progression	137.48	11.63	5	123465	82116	63283436
Pruritus	137.32	11.63	313	123157	361140	63004412
C-reactive protein increased	136.84	11.63	13	123457	94694	63270858
Road traffic accident	136.48	11.63	251	123219	36381	63329171
Injection site induration	133.70	11.63	124	123346	9102	63356450
Injection site atrophy	132.01	11.63	49	123421	594	63364958
Cough	131.32	11.63	230	123240	292513	63073039
Psoriatic arthropathy	131.08	11.63	13	123457	91507	63274045
Head injury	128.67	11.63	208	123262	27188	63338364
Progressive multiple sclerosis	128.51	11.63	57	123413	1121	63364431
Muscle spasms	127.33	11.63	621	122849	155529	63210023
Thyroid cancer	125.87	11.63	97	123373	5514	63360038
Post procedural complication	124.87	11.63	160	123310	16914	63348638
Hypotension	120.61	11.63	216	123254	272388	63093164
Neurogenic bladder	118.60	11.63	76	123394	3209	63362343
Tremor	117.34	11.63	539	122931	131700	63233852
Adverse reaction	115.84	11.63	120	123350	10083	63355469
Wound	115.52	11.63	89	123381	163174	63202378
Breast cancer in situ	115.07	11.63	57	123413	1451	63364101
Folliculitis	112.06	11.63	6	123464	70311	63295241
Multiple sclerosis	111.69	11.63	183	123287	24189	63341363
Blister	109.30	11.63	58	123412	129756	63235796
Hemiparesis	108.30	11.63	176	123294	23106	63342446
Malignant melanoma	106.94	11.63	121	123349	11235	63354317
Arthropathy	106.59	11.63	183	123287	234609	63130943
Maternal exposure timing unspecified	106.09	11.63	97	123373	6990	63358562
Pancytopenia	103.47	11.63	30	123440	96903	63268649
Muscle injury	102.82	11.63	6	123464	65339	63300213
Hip fracture	102.37	11.63	196	123274	29278	63336274
Decreased appetite	98.86	11.63	213	123257	250839	63114713
Hyponatraemia	98.70	11.63	47	123423	111853	63253699
Nephrolithiasis	98.37	11.63	238	123232	41746	63323806
Visual impairment	97.39	11.63	373	123097	84073	63281479
Blindness unilateral	96.52	11.63	87	123383	6154	63359398
Relapsing-remitting multiple sclerosis	96.16	11.63	38	123432	552	63365000
Phobia	95.40	11.63	33	123437	321	63365231
Wheezing	94.24	11.63	34	123436	95561	63269991
Intracranial aneurysm	93.55	11.63	69	123401	3670	63361882
Drug delivery device placement	90.88	11.63	25	123445	101	63365451
Blood creatinine increased	90.49	11.63	29	123441	87815	63277737
Asthenia	89.20	11.63	1138	122332	382466	62983086
Electrocardiogram QT prolonged	89.18	11.63	7	123463	59523	63306029
Loss of personal independence in daily activities	88.70	11.63	39	123431	97251	63268301
Hyperkalaemia	88.37	11.63	4	123466	54199	63311353
Drug abuse	88.12	11.63	17	123453	72501	63293051
Cystitis	88.03	11.63	271	123199	54720	63310832
Upper limb fracture	87.69	11.63	143	123327	18825	63346727
Therapeutic response decreased	87.41	11.63	9	123461	61516	63304036
Discomfort	86.93	11.63	119	123351	167255	63198297
Injection site discolouration	86.76	11.63	91	123379	7757	63357795
Oedema	86.10	11.63	41	123429	97581	63267971
Adverse drug reaction	85.36	11.63	344	123126	79370	63286182
Cholelithiasis	85.31	11.63	232	123238	43693	63321859
Paraesthesia	84.71	11.63	559	122911	156407	63209145
Mobility decreased	84.24	11.63	461	123009	120698	63244854
Ovarian cancer	84.05	11.63	79	123391	5897	63359655
Hypokalaemia	82.19	11.63	50	123420	103754	63261798
Amnesia	81.72	11.63	266	123204	55319	63310233
Sensory disturbance	81.50	11.63	116	123354	13556	63351996
Staphylococcal infection	80.22	11.63	218	123252	41038	63324514
Procedural anxiety	79.71	11.63	36	123434	740	63364812
Vomiting	76.07	11.63	709	122761	558908	62806644
General physical health deterioration	75.07	11.63	176	123294	201226	63164326
Migraine	73.70	11.63	396	123074	102950	63262602
Lower limb fracture	73.22	11.63	152	123318	24069	63341483
Drug specific antibody present	73.12	11.63	63	123407	4196	63361356
Thrombosis	72.99	11.63	284	123186	64471	63301081
Psoriasis	72.97	11.63	39	123431	86918	63278634
Neutralising antibodies positive	72.56	11.63	25	123445	240	63365312
Lung neoplasm malignant	72.46	11.63	134	123336	19499	63346053
Oxygen saturation decreased	71.06	11.63	42	123428	88543	63277009
Injection site nodule	70.50	11.63	59	123411	3776	63361776
Dysgraphia	70.39	11.63	55	123415	3191	63362361
Thrombocytopenia	70.23	11.63	116	123354	151041	63214511
Dysstasia	70.14	11.63	138	123332	21028	63344524
Kidney infection	69.54	11.63	145	123325	23031	63342521
Suicidal ideation	68.93	11.63	272	123198	62149	63303403
Injection site ulcer	68.67	11.63	30	123440	568	63364984
Speech disorder	68.57	11.63	204	123266	40425	63325127
Generalised tonic-clonic seizure	68.52	11.63	165	123305	28851	63336701
Anaemia	68.15	11.63	316	123154	293114	63072438
Appendicitis	68.00	11.63	82	123388	8147	63357405
Haemoglobin decreased	67.26	11.63	112	123358	145373	63220179
Meningioma benign	67.20	11.63	25	123445	305	63365247
Interstitial lung disease	66.36	11.63	19	123451	61889	63303663
Mucosal inflammation	66.32	11.63	7	123463	46921	63318631
Mental impairment	65.84	11.63	107	123363	14044	63351508
Dyspnoea exertional	65.58	11.63	18	123452	60284	63305268
Temperature intolerance	65.54	11.63	84	123386	8880	63356672
Anxiety	64.15	11.63	676	122794	216865	63148687
Invasive ductal breast carcinoma	63.58	11.63	73	123397	6885	63358667
Feeling abnormal	63.58	11.63	500	122970	147892	63217660
COVID-19	63.28	11.63	76	123394	113027	63252525
Blindness	63.06	11.63	134	123336	21565	63343987
Intervertebral disc disorder	62.39	11.63	61	123409	4782	63360770
Pleural effusion	61.94	11.63	54	123416	93156	63272396
Hospitalisation	61.93	11.63	45	123425	85036	63280516
Aphasia	61.79	11.63	172	123298	32828	63332724
Tachycardia	61.34	11.63	84	123386	118072	63247480
Intentional overdose	61.13	11.63	34	123436	74118	63291434
Injury associated with device	60.46	11.63	53	123417	3613	63361939
Influenza	60.33	11.63	390	123080	108332	63257220
Treatment failure	59.23	11.63	194	123276	198849	63166703
Metabolic acidosis	58.19	11.63	9	123461	45060	63320492
Gastric bypass	58.19	11.63	39	123431	1778	63363774
Sinusitis	58.15	11.63	235	123235	226418	63139134
Spinal stenosis	57.78	11.63	104	123366	14821	63350731
Scar	57.18	11.63	99	123371	13683	63351869
Diplopia	57.18	11.63	136	123334	23592	63341960
Epilepsy	56.65	11.63	147	123323	26918	63338634
Productive cough	56.57	11.63	26	123444	63182	63302370
Autoimmune hepatitis	56.42	11.63	76	123394	8434	63357118
Cervix carcinoma	56.40	11.63	47	123423	2990	63362562
Lack of injection site rotation	56.05	11.63	24	123446	432	63365120
Lactic acidosis	55.97	11.63	5	123465	38282	63327270
Endometriosis	55.82	11.63	60	123410	5260	63360292
Cervical spinal stenosis	55.81	11.63	41	123429	2167	63363385
Blood pressure systolic increased	55.74	11.63	12	123458	47385	63318167
Ligament rupture	55.39	11.63	49	123421	3381	63362171
Lumbar spinal stenosis	55.26	11.63	57	123413	4765	63360787
Basedow's disease	54.04	11.63	21	123449	291	63365261
Agraphia	53.95	11.63	13	123457	26	63365526
Intraductal proliferative breast lesion	53.50	11.63	45	123425	2900	63362652
Hypoglycaemia	53.30	11.63	25	123445	60040	63305512
Appendicitis perforated	53.20	11.63	37	123433	1793	63363759
Concussion	53.00	11.63	77	123393	9167	63356385
Neuropathy peripheral	53.00	11.63	87	123383	113580	63251972
Cholecystectomy	52.79	11.63	83	123387	10594	63354958
Primary progressive multiple sclerosis	52.69	11.63	16	123454	98	63365454
Neutrophil count decreased	52.38	11.63	22	123448	56384	63309168
Condition aggravated	52.25	11.63	515	122955	401702	62963850
Therapy non-responder	51.62	11.63	43	123427	75858	63289694
Retinal exudates	51.50	11.63	26	123444	690	63364862
Meningioma	50.17	11.63	49	123421	3836	63361716
Intentional product misuse	50.11	11.63	28	123442	60889	63304663
Multiple organ dysfunction syndrome	49.78	11.63	24	123446	56728	63308824
Medication error	49.18	11.63	20	123450	52264	63313288
Bradycardia	49.17	11.63	42	123428	73185	63292367
Nasal congestion	48.74	11.63	34	123436	65626	63299926
Clostridial infection	48.68	11.63	51	123419	4341	63361211
Irritable bowel syndrome	48.67	11.63	53	123417	82359	63283193
Ovarian cyst	48.12	11.63	100	123370	15845	63349707
Paralysis	47.62	11.63	76	123394	9824	63355728
Inflammation	47.39	11.63	54	123416	82219	63283333
Injection site scab	47.34	11.63	21	123449	413	63365139
Postoperative wound infection	47.33	11.63	80	123390	10845	63354707
Dyspepsia	46.92	11.63	79	123391	102117	63263435
Red blood cell sedimentation rate increased	46.22	11.63	14	123456	43968	63321584
Illness	45.77	11.63	19	123451	49040	63316512
Renal impairment	45.66	11.63	63	123407	88292	63277260
Injury	45.63	11.63	45	123425	73202	63292350
Sedation	45.28	11.63	10	123460	38799	63326753
Colon cancer	45.02	11.63	74	123396	9804	63355748
Thyroid disorder	44.48	11.63	94	123376	15068	63350484
Constipation	44.43	11.63	256	123214	224687	63140865
Intervertebral disc degeneration	44.39	11.63	96	123374	15636	63349916
Depressed mood	44.25	11.63	175	123295	40016	63325536
Hypertension	44.21	11.63	776	122694	278527	63087025
Hypocalcaemia	44.13	11.63	5	123465	31708	63333844
Mouth ulceration	43.94	11.63	6	123464	32978	63332574
Liver function test abnormal	43.88	11.63	198	123272	47983	63317569
Uterine cancer	43.83	11.63	50	123420	4683	63360869
Focal dyscognitive seizures	43.76	11.63	40	123430	2881	63362671
Bipolar disorder	43.75	11.63	65	123405	7895	63357657
Cardiac failure	43.67	11.63	66	123404	89076	63276476
Pulmonary thrombosis	43.51	11.63	68	123402	8634	63356918
Somnolence	43.50	11.63	189	123281	178496	63187056
Breast cancer stage I	43.36	11.63	60	123410	6829	63358723
International normalised ratio increased	43.28	11.63	18	123452	46407	63319145
Malaise	43.12	11.63	1086	122384	414868	62950684
Hypoxia	43.02	11.63	32	123438	59760	63305792
Frustration tolerance decreased	42.70	11.63	60	123410	6928	63358624
Ruptured cerebral aneurysm	42.47	11.63	20	123450	454	63365098
Paraparesis	42.18	11.63	35	123435	2213	63363339
Autoimmune thyroiditis	41.90	11.63	45	123425	3941	63361611
Neoplasm malignant	41.29	11.63	140	123330	29721	63335831
Micturition urgency	41.13	11.63	70	123400	9541	63356011
Overdose	40.93	11.63	103	123367	114975	63250577
Weight increased	40.88	11.63	318	123152	260474	63105078
Abdominal pain upper	40.73	11.63	235	123235	206209	63159343
Haematochezia	40.71	11.63	27	123443	53517	63312035
Burning sensation	40.49	11.63	211	123259	54196	63311356
Product quality issue	40.34	11.63	10	123460	35855	63329697
Injection site calcification	40.26	11.63	10	123460	24	63365528
Depressed level of consciousness	40.00	11.63	37	123433	62041	63303511
Surgery	39.24	11.63	156	123314	35756	63329796
Motor dysfunction	39.15	11.63	73	123397	10688	63354864
Platelet count decreased	38.96	11.63	107	123363	116015	63249537
Vision blurred	38.94	11.63	309	123161	91615	63273937
Paraplegia	38.88	11.63	36	123434	2636	63362916
Band sensation	38.64	11.63	23	123447	850	63364702
Ectopic pregnancy	38.16	11.63	35	123435	2532	63363020
Muscle atrophy	38.04	11.63	57	123413	6976	63358576
Papillary thyroid cancer	37.98	11.63	33	123437	2223	63363329
Gastrointestinal haemorrhage	37.96	11.63	62	123408	81114	63284438
Ataxia	37.59	11.63	88	123382	15107	63350445
Meniscus injury	37.55	11.63	57	123413	7057	63358495
Tibia fracture	37.46	11.63	48	123422	5072	63360480
Cardio-respiratory arrest	37.16	11.63	37	123433	59922	63305630
Procedural pain	37.06	11.63	109	123361	21460	63344092
Erythema	36.89	11.63	196	123274	175555	63189997
Procedural complication	36.71	11.63	49	123421	5390	63360162
Accidental exposure to product	36.47	11.63	5	123465	27400	63338152
Neutralising antibodies	36.43	11.63	10	123460	40	63365512
Brain neoplasm benign	36.16	11.63	14	123456	192	63365360
Sarcoidosis	36.09	11.63	56	123414	7066	63358486
Injection site injury	36.04	11.63	20	123450	646	63364906
Benign breast neoplasm	35.88	11.63	25	123445	1215	63364337
Feeling cold	35.71	11.63	115	123355	23773	63341779
Reaction to preservatives	35.14	11.63	14	123456	208	63365344
Gallbladder disorder	35.07	11.63	98	123372	18744	63346808
Septic shock	34.94	11.63	47	123423	66582	63298970
Nerve compression	34.76	11.63	63	123407	9024	63356528
Bladder dysfunction	34.69	11.63	22	123448	912	63364640
Appendicectomy	34.14	11.63	35	123435	2904	63362648
Incorrect dose administered	33.84	11.63	40	123430	59928	63305624
Injection site fibrosis	33.54	11.63	8	123462	15	63365537
Myelitis transverse	33.22	11.63	24	123446	1236	63364316
Thyroid neoplasm	33.13	11.63	40	123430	3979	63361573
Prolonged labour	32.99	11.63	18	123452	562	63364990
Decreased immune responsiveness	32.84	11.63	44	123426	4857	63360695
Rhinorrhoea	32.65	11.63	48	123422	65529	63300023
Rash pruritic	32.57	11.63	41	123429	59758	63305794
Fear	32.34	11.63	85	123385	15681	63349871
Cellulitis	32.28	11.63	271	123199	81687	63283865
Serotonin syndrome	32.25	11.63	8	123462	28674	63336878
Vertigo	32.09	11.63	213	123257	59674	63305878
Drug ineffective for unapproved indication	32.09	11.63	13	123457	34050	63331502
Brain neoplasm	32.05	11.63	41	123429	4325	63361227
Breech presentation	31.72	11.63	23	123447	1191	63364361
Blood creatine phosphokinase increased	31.41	11.63	10	123460	30420	63335132
Rotator cuff syndrome	31.04	11.63	76	123394	13426	63352126
Drug resistance	30.96	11.63	4	123466	22929	63342623
Mammoplasty	30.78	11.63	17	123453	544	63365008
Anal incontinence	30.77	11.63	76	123394	13500	63352052
Pneumonitis	30.73	11.63	15	123455	35207	63330345
Dry mouth	30.65	11.63	66	123404	77797	63287755
Prescribed overdose	30.63	11.63	14	123456	34139	63331413
Drug level increased	30.61	11.63	4	123466	22732	63342820
Optic nerve disorder	30.49	11.63	20	123450	879	63364673
Product administered at inappropriate site	30.41	11.63	34	123436	3115	63362437
Central venous catheterisation	30.28	11.63	31	123439	2568	63362984
Pulmonary sarcoidosis	30.11	11.63	21	123449	1022	63364530
Haemorrhage in pregnancy	30.09	11.63	27	123443	1898	63363654
Oral pain	29.90	11.63	9	123461	28385	63337167
Expanded disability status scale score increased	29.82	11.63	17	123453	579	63364973
Full blood count decreased	29.77	11.63	7	123463	26017	63339535
Injection site inflammation	29.66	11.63	37	123433	3806	63361746
Mental disorder	29.46	11.63	114	123356	25805	63339747
Gastrointestinal disorder	29.44	11.63	143	123327	131096	63234456
Haemolytic uraemic syndrome	29.43	11.63	30	123440	2473	63363079
Injection site irritation	29.32	11.63	42	123428	4936	63360616
Raynaud's phenomenon	29.31	11.63	22	123448	1202	63364350
Delirium	29.29	11.63	33	123437	50508	63315044
Oedema peripheral	29.25	11.63	232	123238	189279	63176273
Varicose vein	29.21	11.63	42	123428	4953	63360599
Drug dependence	29.19	11.63	6	123464	24477	63341075
Hepatitis C	28.89	11.63	43	123427	5231	63360321
Benign lung neoplasm	28.86	11.63	9	123461	61	63365491
Frequent bowel movements	28.82	11.63	5	123465	23017	63342535
Diplegia	28.82	11.63	21	123449	1096	63364456
Pain in extremity	28.77	11.63	846	122624	330640	63034912
Blood potassium decreased	28.57	11.63	159	123311	41867	63323685
Blood calcium decreased	28.56	11.63	8	123462	26443	63339109
Rhabdomyolysis	28.55	11.63	26	123444	43925	63321627
Bladder cancer	28.53	11.63	44	123426	5522	63360030
JC polyomavirus test	28.39	11.63	8	123462	36	63365516
Product prescribing error	28.29	11.63	8	123462	26281	63339271
Agranulocytosis	28.28	11.63	7	123463	25127	63340425
Hypersensitivity	28.21	11.63	400	123070	292285	63073267
Hypervolaemia	28.17	11.63	10	123460	28403	63337149
Porphyria non-acute	28.06	11.63	13	123457	284	63365268
Myelosuppression	27.87	11.63	6	123464	23697	63341855
No adverse event	27.71	11.63	156	123314	41249	63324303
Liver injury	27.57	11.63	47	123423	60473	63305079
Back disorder	27.47	11.63	64	123406	10953	63354599
Muscle tightness	27.37	11.63	67	123403	11833	63353719
Dysarthria	27.33	11.63	159	123311	42552	63323000
Obstructive airways disorder	27.02	11.63	4	123466	20695	63344857
Dry skin	27.01	11.63	43	123427	56844	63308708
Heavy menstrual bleeding	26.97	11.63	86	123384	17687	63347865
Chronic leukaemia	26.84	11.63	6	123464	7	63365545
Coronary artery disease	26.51	11.63	129	123341	32248	63333304
Thyroid function test abnormal	26.38	11.63	34	123436	3613	63361939
Cellulitis staphylococcal	26.25	11.63	17	123453	731	63364821
Blood pressure diastolic decreased	26.19	11.63	6	123464	22700	63342852
Vitamin D decreased	26.09	11.63	60	123410	10182	63355370
Retinal tear	26.07	11.63	21	123449	1273	63364279
Colon cancer stage III	26.03	11.63	10	123460	134	63365418
Blood pressure fluctuation	26.02	11.63	31	123439	46286	63319266
Panic attack	26.02	11.63	99	123371	22232	63343320
Febrile convulsion	25.87	11.63	14	123456	430	63365122
Rash maculo-papular	25.75	11.63	15	123455	31881	63333671
Fibula fracture	25.59	11.63	33	123437	3509	63362043
Neuralgia	25.47	11.63	109	123361	25817	63339735
Musculoskeletal stiffness	25.36	11.63	233	123237	184385	63181167
Cytomegalovirus infection	25.26	11.63	5	123465	20947	63344605
Rectocele	25.25	11.63	19	123451	1042	63364510
Uterine disorder	25.24	11.63	31	123439	3138	63362414
Ligament sprain	25.24	11.63	68	123402	12732	63352820
Headache	25.11	11.63	1487	121983	631754	62733798
Endometrial cancer	24.81	11.63	31	123439	3194	63362358
Hypercalcaemia	24.80	11.63	12	123458	28310	63337242
Bone marrow failure	24.76	11.63	13	123457	29277	63336275
Loss of consciousness	24.68	11.63	344	123126	117777	63247775
Abdominal distension	24.66	11.63	86	123384	86529	63279023
Breast cancer recurrent	24.66	11.63	36	123434	4305	63361247
Hemianaesthesia	24.54	11.63	13	123457	382	63365170
Lung adenocarcinoma	24.50	11.63	37	123433	4560	63360992
Wound infection staphylococcal	24.36	11.63	28	123442	2644	63362908
Eosinophilia	24.35	11.63	7	123463	22749	63342803
Infection	24.32	11.63	307	123163	228866	63136686
Breast cancer stage II	24.29	11.63	53	123417	8683	63356869
Conversion disorder	24.20	11.63	23	123447	1741	63363811
Blindness transient	24.15	11.63	33	123437	3711	63361841
Bone erosion	24.14	11.63	3	123467	17714	63347838
Inappropriate schedule of product administration	24.06	11.63	112	123358	103853	63261699
Demyelination	24	11.63	46	123424	6874	63358678
Angioedema	23.99	11.63	35	123435	47930	63317622
Fluid retention	23.98	11.63	50	123420	59636	63305916
Calculus bladder	23.87	11.63	15	123455	612	63364940
Cartilage injury	23.80	11.63	24	123446	1953	63363599
Joint range of motion decreased	23.79	11.63	17	123453	32411	63333141
Poor venous access	23.78	11.63	73	123397	14712	63350840
Injection site anaesthesia	23.76	11.63	7	123463	38	63365514
Goitre	23.66	11.63	42	123428	5919	63359633
Anaphylactic reaction	23.62	11.63	59	123411	66041	63299511
Cholestasis	23.53	11.63	14	123456	29420	63336132
Pollakiuria	23.37	11.63	112	123358	27825	63337727
Scoliosis	23.25	11.63	49	123421	7839	63357713
Agitation	23.23	11.63	51	123419	59706	63305846
Dry eye	23.20	11.63	27	123443	40734	63324818
Chronic lymphocytic leukaemia	23.17	11.63	27	123443	2587	63362965
Incontinence	23.14	11.63	62	123408	11570	63353982
Impaired self-care	23.06	11.63	23	123447	1847	63363705
Hernia	23.01	11.63	65	123405	12509	63353043
Partial seizures	22.98	11.63	41	123429	5801	63359751
Suicidal behaviour	22.96	11.63	27	123443	2612	63362940
Fear of injection	22.88	11.63	46	123424	7118	63358434
Nerve injury	22.88	11.63	56	123414	9890	63355662
Respiratory failure	22.83	11.63	111	123359	101747	63263805
Pneumocystis jirovecii pneumonia	22.71	11.63	3	123467	16911	63348641
Wrist fracture	22.71	11.63	68	123402	13519	63352033
Lung adenocarcinoma stage I	22.71	11.63	6	123464	20	63365532
Lung disorder	22.70	11.63	55	123415	62206	63303346
Deafness unilateral	22.61	11.63	29	123441	3067	63362485
Pain in jaw	22.48	11.63	31	123439	43465	63322087
Throat irritation	22.46	11.63	24	123446	37623	63327929
Renal cell carcinoma	22.44	11.63	30	123440	3305	63362247
Emotional disorder	22.40	11.63	67	123403	13312	63352240
Oropharyngeal pain	22.34	11.63	101	123369	94386	63271166
Foot fracture	22.32	11.63	99	123371	23815	63341737
Urosepsis	22.31	11.63	83	123387	18441	63347111
Urinary tract disorder	22.20	11.63	28	123442	2913	63362639
Gallbladder operation	22.12	11.63	25	123445	2318	63363234
Ascites	22.10	11.63	28	123442	40700	63324852
Lumbar radiculopathy	22.07	11.63	23	123447	1946	63363606
Anti-interferon antibody positive	22.06	11.63	6	123464	23	63365529
Crying	22.06	11.63	97	123373	23246	63342306
Pulmonary fibrosis	21.99	11.63	27	123443	39782	63325770
Thermal burn	21.97	11.63	41	123429	6005	63359547
JC polyomavirus test positive	21.97	11.63	20	123450	1433	63364119
Post procedural haemorrhage	21.79	11.63	48	123422	7916	63357636
Cervical dysplasia	21.76	11.63	29	123441	3185	63362367
Intervertebral disc operation	21.69	11.63	16	123454	851	63364701
Creatinine renal clearance decreased	21.64	11.63	3	123467	16305	63349247
Intervertebral disc injury	21.49	11.63	9	123461	153	63365399
Tachypnoea	21.13	11.63	4	123466	17298	63348254
Lipoatrophy	21.12	11.63	11	123459	312	63365240
Cholecystitis infective	21.11	11.63	21	123449	1681	63363871
Spondylolisthesis	21.07	11.63	30	123440	3506	63362046
Hepatic steatosis	21.01	11.63	111	123359	28658	63336894
Oral candidiasis	20.99	11.63	9	123461	22789	63342763
Fractured coccyx	20.94	11.63	17	123453	1042	63364510
Spinal disorder	20.94	11.63	54	123416	9848	63355704
Abnormal labour	20.92	11.63	7	123463	61	63365491
Fat necrosis	20.74	11.63	14	123456	646	63364906
Dysgeusia	20.62	11.63	37	123433	46673	63318879
Haemorrhagic adrenal infarction	20.61	11.63	6	123464	31	63365521
Rubber sensitivity	20.53	11.63	24	123446	2307	63363245
Orthostatic hypotension	20.53	11.63	24	123446	36136	63329416
Anaesthetic complication	20.38	11.63	22	123448	1938	63363614
Rash erythematous	20.31	11.63	32	123438	42478	63323074
Cholecystitis	20.30	11.63	71	123399	15306	63350246
Atrial fibrillation	20.28	11.63	138	123332	116498	63249054
Lip dry	20.17	11.63	3	123467	15467	63350085
Benign hydatidiform mole	20.13	11.63	8	123462	118	63365434
Limb mass	20.12	11.63	28	123442	3204	63362348
Feeling of body temperature change	20.08	11.63	35	123435	4862	63360690
Schwannoma	20.06	11.63	7	123463	70	63365482
Impaired healing	20.06	11.63	117	123353	102425	63263127
Relapsing multiple sclerosis	20.02	11.63	9	123461	183	63365369
Chronic kidney disease	20.00	11.63	36	123434	45362	63320190
Withdrawal syndrome	19.89	11.63	7	123463	19990	63345562
Precancerous cells present	19.88	11.63	19	123451	1448	63364104
Focal segmental glomerulosclerosis	19.87	11.63	19	123451	1449	63364103
Basal cell carcinoma	19.76	11.63	107	123363	27884	63337668
Facial bones fracture	19.75	11.63	31	123439	3951	63361601
Tubulointerstitial nephritis	19.74	11.63	7	123463	19896	63345656
Progesterone receptor assay positive	19.72	11.63	11	123459	359	63365193
Knee operation	19.67	11.63	39	123431	5974	63359578
Umbilical cord around neck	19.62	11.63	9	123461	192	63365360
Gait spastic	19.52	11.63	10	123460	274	63365278
Acute respiratory failure	19.46	11.63	23	123447	34462	63331090
Drug intolerance	19.28	11.63	455	123015	308206	63057346
Haematuria	19.23	11.63	17	123453	29140	63336412
Thrombotic thrombocytopenic purpura	19.21	11.63	30	123440	3806	63361746
Colostomy closure	19.21	11.63	8	123462	134	63365418
Skin exfoliation	19.15	11.63	34	123436	43068	63322484
Incision site complication	19.01	11.63	13	123457	613	63364939
Cephalo-pelvic disproportion	19.00	11.63	9	123461	207	63365345
Atrophy	19.00	11.63	20	123450	1712	63363840
Fibromyalgia	18.99	11.63	86	123384	80334	63285218
Rectal haemorrhage	18.93	11.63	42	123428	48988	63316564
Product substitution issue	18.91	11.63	4	123466	15992	63349560
Oestrogen receptor assay positive	18.87	11.63	12	123458	500	63365052
Urinary retention	18.86	11.63	112	123358	30189	63335363
Foetal heart rate abnormal	18.80	11.63	13	123457	624	63364928
Sleep disorder	18.80	11.63	88	123382	81478	63284074
Ovarian neoplasm	18.79	11.63	15	123455	898	63364654
Arterial occlusive disease	18.72	11.63	38	123432	5920	63359632
Skin cancer	18.71	11.63	57	123413	11438	63354114
Ocular hyperaemia	18.68	11.63	13	123457	25131	63340421
Rectal cancer	18.65	11.63	22	123448	2136	63363416
Face oedema	18.58	11.63	8	123462	20204	63345348
Hepatotoxicity	18.55	11.63	27	123443	37014	63328538
Malignant melanoma in situ	18.51	11.63	15	123455	917	63364635
Volvulus	18.49	11.63	20	123450	1766	63363786
Gun shot wound	18.43	11.63	8	123462	149	63365403
Aneurysm	18.32	11.63	25	123445	2808	63362744
Magnetic resonance imaging head abnormal	18.19	11.63	21	123449	1992	63363560
Incisional hernia	18.18	11.63	19	123451	1613	63363939
Breast calcifications	18.17	11.63	17	123453	1261	63364291
Optic atrophy	18.17	11.63	17	123453	1261	63364291
Incoherent	18.09	11.63	32	123438	4498	63361054
Injection site swelling	18.04	11.63	156	123314	47416	63318136
Cerebral atrophy	17.97	11.63	34	123436	5032	63360520
Oophorectomy	17.92	11.63	12	123458	546	63365006
Cardiac disorder	17.91	11.63	164	123306	50652	63314900
Hand fracture	17.88	11.63	36	123434	5577	63359975
Eye pruritus	17.79	11.63	7	123463	18664	63346888
Post procedural infection	17.79	11.63	49	123421	9293	63356259
Large intestine polyp	17.79	11.63	45	123425	8112	63357440
Intervertebral disc displacement	17.74	11.63	11	123459	438	63365114
Gastric cyst	17.69	11.63	7	123463	102	63365450
Post procedural stroke	17.66	11.63	6	123464	55	63365497
Drug tolerance decreased	17.58	11.63	6	123464	17467	63348085
Haemorrhagic ovarian cyst	17.48	11.63	13	123457	700	63364852
Fibrocystic breast disease	17.23	11.63	16	123454	1176	63364376
Muscle disorder	17.20	11.63	33	123437	4936	63360616
Endometrial cancer stage I	17.19	11.63	9	123461	258	63365294
Female genital operation	17.15	11.63	5	123465	26	63365526
Musculoskeletal pain	17.15	11.63	107	123363	92170	63273382
Umbilical hernia	17.13	11.63	25	123445	2989	63362563
Cardiac perforation	17.11	11.63	6	123464	61	63365491
Homicidal ideation	17.06	11.63	19	123451	1733	63363819
Injection site hypertrophy	17.02	11.63	6	123464	62	63365490
Enterocele	16.85	11.63	6	123464	64	63365488
Myelitis	16.83	11.63	17	123453	1386	63364166
Nodule	16.81	11.63	10	123460	21016	63344536
Hyperaesthesia	16.76	11.63	48	123422	9310	63356242
Cervical vertebral fracture	16.67	11.63	23	123447	2611	63362941
Skin graft	16.63	11.63	12	123458	617	63364935
Adrenal insufficiency	16.61	11.63	7	123463	17908	63347644
Epistaxis	16.44	11.63	79	123391	72646	63292906
Skull fracture	16.41	11.63	15	123455	1080	63364472
Viral pericarditis	16.41	11.63	5	123465	31	63365521
Vein disorder	16.41	11.63	33	123437	5108	63360444
Haemoptysis	16.38	11.63	19	123451	28707	63336845
Cerebral cyst	16.35	11.63	9	123461	286	63365266
Lipodystrophy acquired	16.34	11.63	17	123453	1435	63364117
Tumefactive multiple sclerosis	16.29	11.63	6	123464	71	63365481
Lacrimation increased	16.23	11.63	10	123460	20621	63344931
Osteoarthritis	16.17	11.63	268	123202	95075	63270477
Injection site rash	16.16	11.63	76	123394	18733	63346819
Acute disseminated encephalomyelitis	16.14	11.63	8	123462	204	63365348
Ovarian cancer stage III	16.13	11.63	9	123461	294	63365258
Hyperglycaemia	16.05	11.63	36	123434	41831	63323721
Uterine mass	16.01	11.63	9	123461	298	63365254
Chondropathy	15.95	11.63	21	123449	2279	63363273
Lyme disease	15.94	11.63	26	123444	3423	63362129
Drug delivery system malfunction	15.90	11.63	15	123455	1125	63364427
Cerebral thrombosis	15.89	11.63	18	123452	1673	63363879
Visual acuity reduced	15.79	11.63	84	123386	21742	63343810
Colon cancer metastatic	15.77	11.63	15	123455	1136	63364416
Spider vein	15.77	11.63	9	123461	307	63365245
Biopsy bladder	15.73	11.63	3	123467	0	63365552
Neurological complication associated with device	15.73	11.63	3	123467	0	63365552
Rectal cancer stage I	15.73	11.63	3	123467	0	63365552
Urinary control neurostimulator implantation	15.73	11.63	3	123467	0	63365552
Face presentation	15.73	11.63	3	123467	0	63365552
Breast dysplasia	15.73	11.63	3	123467	0	63365552
Neurilemmoma benign	15.73	11.63	3	123467	0	63365552
Rib fracture	15.69	11.63	86	123384	22511	63343041
Pregnancy	15.68	11.63	124	123346	36712	63328840
Abortion missed	15.65	11.63	18	123452	1701	63363851
Glioblastoma	15.64	11.63	13	123457	824	63364728
Lung cancer metastatic	15.54	11.63	22	123448	2558	63362994
Heat stroke	15.49	11.63	13	123457	835	63364717
Skin laceration	15.49	11.63	86	123384	22622	63342930
Heat exhaustion	15.45	11.63	7	123463	145	63365407
Suture rupture	15.42	11.63	8	123462	225	63365327
Haematemesis	15.39	11.63	22	123448	30390	63335162
Pneumonia	15.38	11.63	1058	122412	455709	62909843
Rales	15.37	11.63	3	123467	12694	63352858
Facial paralysis	15.34	11.63	61	123409	13980	63351572
Disseminated intravascular coagulation	15.32	11.63	9	123461	19042	63346510
Joint effusion	15.29	11.63	7	123463	17053	63348499
Reproductive tract disorder	15.27	11.63	7	123463	149	63365403
Pancreatic cyst	15.24	11.63	17	123453	1553	63363999
Exposure during pregnancy	15.17	11.63	212	123258	155335	63210217
Malignant hypertension	15.11	11.63	15	123455	1198	63364354
Paternal exposure before pregnancy	15.10	11.63	5	123465	42	63365510
Skin indentation	15.10	11.63	5	123465	42	63365510
Shock	15.09	11.63	14	123456	23449	63342103
Tenderness	15.09	11.63	13	123457	22565	63342987
Ill-defined disorder	15.09	11.63	95	123375	81660	63283892
Upper gastrointestinal haemorrhage	15.03	11.63	9	123461	18843	63346709
Carotid artery aneurysm	15.01	11.63	9	123461	337	63365215
Asthma	15.01	11.63	167	123303	127394	63238158
Bursitis	14.90	11.63	31	123439	37010	63328542
Endometrial adenocarcinoma	14.87	11.63	15	123455	1221	63364331
Product administration error	14.84	11.63	13	123457	22384	63343168
Meningitis viral	14.77	11.63	16	123454	1415	63364137
Hypothyroidism	14.73	11.63	137	123333	42495	63323057
Brain operation	14.70	11.63	11	123459	598	63364954
Leukopenia	14.68	11.63	89	123381	77201	63288351
Cervix carcinoma stage 0	14.62	11.63	9	123461	354	63365198
Nephrotic syndrome	14.57	11.63	33	123437	5543	63360009
Sleep disorder due to a general medical condition	14.50	11.63	3	123467	12185	63353367
Limb injury	14.49	11.63	92	123378	25385	63340167
Plasma cell myeloma	14.49	11.63	30	123440	35875	63329677
Joint stiffness	14.47	11.63	38	123432	41831	63323721
Ophthalmoplegia	14.47	11.63	16	123454	1448	63364104
Spinal cord disorder	14.42	11.63	15	123455	1266	63364286
Uterine leiomyosarcoma	14.38	11.63	4	123466	17	63365535
Urinary tract infection staphylococcal	14.37	11.63	9	123461	365	63365187
Postoperative thrombosis	14.36	11.63	7	123463	172	63365380
Injection site hypoaesthesia	14.33	11.63	10	123460	487	63365065
Incision site abscess	14.32	11.63	9	123461	367	63365185
Exposure via father	14.26	11.63	8	123462	264	63365288
Hypoacusis	14.23	11.63	88	123382	24063	63341489
Ovarian germ cell teratoma benign	14.22	11.63	6	123464	104	63365448
Osteonecrosis	14.21	11.63	89	123381	24441	63341111
Abdominal operation	14.20	11.63	11	123459	630	63364922
Normal newborn	14.18	11.63	42	123428	8299	63357253
Spinal meningeal cyst	14.16	11.63	5	123465	52	63365500
Serum serotonin decreased	14.02	11.63	4	123466	19	63365533
Amniotic fluid volume decreased	14.00	11.63	10	123460	506	63365046
Right ventricular failure	13.99	11.63	8	123462	17180	63348372
Pulmonary oedema	13.98	11.63	57	123413	54816	63310736
Injection related reaction	13.96	11.63	12	123458	797	63364755
Wrong technique in product usage process	13.93	11.63	68	123402	62272	63303280
Bladder prolapse	13.90	11.63	19	123451	2137	63363415
Bronchiectasis	13.89	11.63	7	123463	16135	63349417
Benign pancreatic neoplasm	13.85	11.63	4	123466	20	63365532
Patella fracture	13.84	11.63	19	123451	2147	63363405
Urticaria	13.78	11.63	233	123237	165569	63199983
Stevens-Johnson syndrome	13.70	11.63	17	123453	24933	63340619
Colostomy infection	13.66	11.63	3	123467	3	63365549
Intestinal ulcer perforation	13.66	11.63	3	123467	3	63365549
Vaccination complication	13.64	11.63	14	123456	1163	63364389
Injection site pruritus	13.64	11.63	141	123329	44975	63320577
Suture related complication	13.62	11.63	7	123463	193	63365359
Adenomyosis	13.62	11.63	10	123460	528	63365024
Spinal osteoarthritis	13.61	11.63	65	123405	16121	63349431
Lipoma	13.58	11.63	20	123450	2411	63363141
Dysphemia	13.51	11.63	21	123449	2654	63362898
Pituitary tumour benign	13.50	11.63	18	123452	1977	63363575
Intervertebral disc compression	13.44	11.63	14	123456	1184	63364368
Paraganglion neoplasm	13.39	11.63	4	123466	23	63365529
Quadriplegia	13.37	11.63	17	123453	1783	63363769
Restlessness	13.30	11.63	23	123447	29430	63336122
Uterine cyst	13.30	11.63	9	123461	417	63365135
Oophorectomy bilateral	13.30	11.63	5	123465	63	63365489
Clavicle fracture	13.28	11.63	24	123446	3431	63362121
Non-small cell lung cancer stage IIIB	13.20	11.63	3	123467	4	63365548
Faeces discoloured	13.19	11.63	10	123460	18499	63347053
Disease progression	13.18	11.63	164	123306	122594	63242958
Injection site vesicles	13.16	11.63	22	123448	2955	63362597
Bone pain	13.16	11.63	58	123412	54583	63310969
Uterine polyp	13.12	11.63	18	123452	2032	63363520
Benign uterine neoplasm	13.10	11.63	4	123466	25	63365527
Invasive lobular breast carcinoma	12.91	11.63	12	123458	883	63364669
Petit mal epilepsy	12.89	11.63	25	123445	3769	63361783
Spinal laminectomy	12.88	11.63	11	123459	724	63364828
Cold type haemolytic anaemia	12.87	11.63	7	123463	217	63365335
Inappropriate antidiuretic hormone secretion	12.87	11.63	7	123463	15455	63350097
Cast application	12.84	11.63	4	123466	27	63365525
Nasal sinus cancer	12.84	11.63	4	123466	27	63365525
Apparent death	12.83	11.63	14	123456	1248	63364304
Gastrointestinal viral infection	12.79	11.63	14	123456	1253	63364299
Pre-eclampsia	12.78	11.63	43	123427	9090	63356462
Crohn's disease	12.75	11.63	29	123441	4884	63360668
Benign neoplasm of bladder	12.72	11.63	4	123466	28	63365524
Lumbar puncture	12.71	11.63	6	123464	137	63365415
Uterine prolapse	12.70	11.63	14	123456	1263	63364289
Thyroid cyst	12.55	11.63	10	123460	597	63364955
Hepatic adenoma	12.54	11.63	8	123462	335	63365217
Arterial therapeutic procedure	12.48	11.63	4	123466	30	63365522
Blood urea increased	12.47	11.63	20	123450	26359	63339193
Breath sounds abnormal	12.46	11.63	3	123467	10970	63354582
Lhermitte's sign	12.45	11.63	3	123467	6	63365546
Non-small cell lung cancer stage I	12.45	11.63	3	123467	6	63365546
Opportunistic infection	12.44	11.63	17	123453	1912	63363640
Female sterilisation	12.43	11.63	10	123460	605	63364947
Cervical incompetence	12.40	11.63	10	123460	607	63364945
Complication of pregnancy	12.36	11.63	10	123460	610	63364942
Appendix disorder	12.33	11.63	15	123455	1504	63364048
Benign neoplasm of thyroid gland	12.32	11.63	13	123457	1116	63364436
Diabetic ketoacidosis	12.31	11.63	13	123457	20492	63345060
Blood pressure decreased	12.28	11.63	75	123395	64947	63300605
Pelvic fracture	12.26	11.63	55	123415	13293	63352259
Progressive relapsing multiple sclerosis	12.25	11.63	4	123466	32	63365520
Gestational hypertension	12.24	11.63	19	123451	2398	63363154
Aspartate aminotransferase abnormal	12.23	11.63	13	123457	1125	63364427
Fatigue	12.23	11.63	1935	121535	886093	62479459
Vulval cancer	12.23	11.63	11	123459	776	63364776
Post procedural swelling	12.19	11.63	8	123462	352	63365200
Eczema	12.19	11.63	28	123442	32263	63333289
Staphylococcal osteomyelitis	12.17	11.63	6	123464	151	63365401
Injection site erosion	12.16	11.63	5	123465	81	63365471
Abdominal adhesions	12.09	11.63	22	123448	3160	63362392
Renal tubular necrosis	12.09	11.63	4	123466	11874	63353678
Myoclonus	12.06	11.63	8	123462	15860	63349692
Pain	12.06	11.63	1259	122211	739369	62626183
Gastric banding	12.05	11.63	5	123465	83	63365469
Eye irritation	12.03	11.63	15	123455	21956	63343596
Toxic skin eruption	12.00	11.63	5	123465	12880	63352672
Hypoalbuminaemia	11.97	11.63	4	123466	11801	63353751
Liver function test increased	11.95	11.63	29	123441	32782	63332770
Lipoma excision	11.94	11.63	4	123466	35	63365517
Haemangioma	11.93	11.63	20	123450	2692	63362860
Therapy partial responder	11.93	11.63	3	123467	10655	63354897
Urinary bladder suspension	11.89	11.63	9	123461	498	63365054
Product complaint	11.88	11.63	5	123465	12804	63352748
Myofascitis	11.85	11.63	3	123467	8	63365544
Accident	11.85	11.63	32	123438	6000	63359552
Narcolepsy	11.83	11.63	14	123456	1364	63364188
Carcinoid tumour of the stomach	11.82	11.63	6	123464	161	63365391
Hepatocellular injury	11.81	11.63	22	123448	27359	63338193
Dysphonia	11.79	11.63	50	123420	47564	63317988
Uterine haemorrhage	11.79	11.63	25	123445	4016	63361536
Immune system disorder	11.79	11.63	44	123426	9790	63355762
Decreased interest	11.74	11.63	22	123448	3232	63362320
Device dislocation	11.67	11.63	20	123450	25685	63339867
Primary biliary cholangitis	11.67	11.63	13	123457	1186	63364366
Injection site discomfort	11.66	11.63	27	123443	4603	63360949
Pernicious anaemia	11.63	11.63	10	123460	664	63364888

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Multiple sclerosis relapse	3262.12	15.20	941	28630	12192	34915168
Influenza like illness	1448.40	15.20	622	28949	27012	34900348
Gait disturbance	320.64	15.20	377	29194	84763	34842597
General symptom	313.47	15.20	84	29487	800	34926560
Injection site erythema	308.67	15.20	183	29388	15716	34911644
Central nervous system lesion	297.22	15.20	133	29438	6330	34921030
Fall	258.74	15.20	545	29026	202340	34725020
Memory impairment	235.30	15.20	233	29338	43085	34884275
Urinary tract infection	233.42	15.20	320	29251	83761	34843599
Balance disorder	219.55	15.20	218	29353	40436	34886924
Muscle spasticity	199.11	15.20	98	29473	5790	34921570
Injection site pain	193.86	15.20	200	29371	38805	34888555
Hypoaesthesia	192.16	15.20	248	29323	61196	34866164
Mobility decreased	184.18	15.20	173	29398	29955	34897405
Off label use	177.60	15.20	67	29504	419457	34507903
Depression	167.67	15.20	297	29274	96801	34830559
Injection site infection	153.59	15.20	50	29521	976	34926384
Cognitive disorder	138.69	15.20	145	29426	28548	34898812
Toxicity to various agents	137.51	15.20	8	29563	200354	34727006
Acute kidney injury	136.95	15.20	44	29527	304944	34622416
Progressive multiple sclerosis	131.73	15.20	33	29538	234	34927126
Injection site reaction	131.66	15.20	100	29471	12933	34914427
Drug interaction	128.78	15.20	19	29552	225927	34701433
Relapsing-remitting multiple sclerosis	128.64	15.20	44	29527	1006	34926354
Needle fatigue	128.11	15.20	42	29529	839	34926521
Muscular weakness	125.76	15.20	223	29348	72674	34854686
Optic neuritis	125.36	15.20	61	29510	3513	34923847
Gait inability	124.53	15.20	118	29453	20640	34906720
Secondary progressive multiple sclerosis	123.69	15.20	34	29537	359	34927001
Myocardial infarction	122.25	15.20	297	29274	120788	34806572
Injection site cellulitis	119.09	15.20	36	29535	545	34926815
Loss of control of legs	114.93	15.20	37	29534	696	34926664
Gait spastic	111.53	15.20	40	29531	1056	34926304
Diarrhoea	110.20	15.20	101	29470	389811	34537549
Magnetic resonance imaging abnormal	109.10	15.20	44	29527	1612	34925748
Hypertonic bladder	100.76	15.20	43	29528	1821	34925539
Decubitus ulcer	98.02	15.20	72	29499	8849	34918511
Injection site abscess	97.89	15.20	34	29537	815	34926545
Seizure	89.99	15.20	242	29329	104615	34822745
Monoparesis	85.17	15.20	41	29530	2305	34925055
Intervertebral disc protrusion	84.61	15.20	69	29502	9887	34917473
Dyspnoea	84.17	15.20	118	29453	376664	34550696
Anaemia	83.32	15.20	47	29524	233288	34694072
Trigeminal neuralgia	82.16	15.20	33	29538	1196	34926164
Neutropenia	80.93	15.20	17	29554	156761	34770599
Road traffic accident	75.17	15.20	83	29488	17367	34909993
Coronary artery occlusion	72.86	15.20	66	29505	10896	34916464
Ataxia	72.32	15.20	73	29498	13780	34913580
Injection site induration	71.86	15.20	39	29532	2821	34924539
Hypotension	71.73	15.20	50	29521	221599	34705761
Coordination abnormal	71.40	15.20	56	29515	7588	34919772
Cystitis	67.28	15.20	60	29511	9705	34917655
Multiple sclerosis	67.13	15.20	51	29520	6594	34920766
Bladder disorder	61.39	15.20	37	29534	3267	34924093
Micturition urgency	61.37	15.20	48	29523	6477	34920883
Injection site haematoma	61.20	15.20	30	29541	1755	34925605
Thrombocytopenia	59.37	15.20	29	29542	156218	34771142
Musculoskeletal disorder	59.13	15.20	46	29525	6158	34921202
Visual impairment	57.18	15.20	106	29465	35696	34891664
Injection site scar	53.60	15.20	17	29554	304	34927056
Anxiety	53.29	15.20	195	29376	99233	34828127
Injection site necrosis	52.15	15.20	18	29553	423	34926937
Procedural anxiety	52.10	15.20	9	29562	3	34927357
Neurogenic bladder	51.99	15.20	27	29544	1786	34925574
Hyponatraemia	51.83	15.20	5	29566	82686	34844674
Adverse drug reaction	50.82	15.20	90	29481	29252	34898108
Injection site bruising	49.57	15.20	48	29523	8615	34918745
Movement disorder	47.21	15.20	55	29516	12193	34915167
Dysarthria	47.03	15.20	96	29475	34686	34892674
Peroneal nerve palsy	46.55	15.20	30	29541	2981	34924379
Pain	45.80	15.20	313	29258	204362	34722998
Blood creatinine increased	45.61	15.20	12	29559	94964	34832396
Abdominal pain	45.30	15.20	43	29528	163575	34763785
Drug abuse	44.86	15.20	14	29557	99082	34828278
Muscle spasms	44.38	15.20	152	29419	74849	34852511
Drug delivery device placement	44.15	15.20	12	29559	121	34927239
Nausea	43.61	15.20	145	29426	339763	34587597
Interstitial lung disease	43.53	15.20	3	29568	65279	34862081
Chills	42.61	15.20	158	29413	80885	34846475
Renal impairment	41.63	15.20	14	29557	94499	34832861
Hyperkalaemia	41.43	15.20	5	29566	69384	34857976
Product use in unapproved indication	41.39	15.20	24	29547	117475	34809885
Dysstasia	40.85	15.20	51	29520	12144	34915216
Haemoglobin decreased	40.68	15.20	26	29545	120746	34806614
Primary progressive multiple sclerosis	39.84	15.20	9	29562	38	34927322
Product use issue	39.15	15.20	4	29567	63212	34864148
Pancytopenia	38.72	15.20	16	29555	95141	34832219
Platelet count decreased	38.67	15.20	27	29544	119690	34807670
Respiratory failure	38.49	15.20	22	29549	108550	34818810
Rash	38.40	15.20	82	29489	222670	34704690
Amnesia	37.91	15.20	75	29496	26488	34900872
Glioblastoma	36.91	15.20	18	29553	1041	34926319
Bipolar disorder	36.70	15.20	28	29543	3641	34923719
Cerebrovascular accident	36.26	15.20	155	29416	84656	34842704
Injection site haemorrhage	36.21	15.20	43	29528	9725	34917635
Decreased appetite	36.12	15.20	53	29518	166339	34761021
Pleural effusion	36.05	15.20	12	29559	81534	34845826
Speech disorder	36.03	15.20	72	29499	25614	34901746
Lower limb fracture	35.87	15.20	29	29542	4102	34923258
Generalised tonic-clonic seizure	35.45	15.20	64	29507	21110	34906250
Hemiparesis	34.85	15.20	54	29517	15724	34911636
Spinal fusion surgery	34.52	15.20	17	29554	1004	34926356
Head injury	34.45	15.20	58	29513	18102	34909258
Paralysis	33.49	15.20	33	29538	6049	34921311
Blindness unilateral	33.47	15.20	29	29542	4513	34922847
Neutralising antibodies positive	32.74	15.20	9	29562	95	34927265
Prostate cancer	32.43	15.20	90	29481	39559	34887801
Pollakiuria	32.34	15.20	59	29512	19615	34907745
Testicular infarction	32.27	15.20	8	29563	54	34927306
Adverse reaction	32.25	15.20	24	29547	3007	34924353
Asthenia	31.83	15.20	332	29239	244919	34682441
Tachycardia	31.76	15.20	16	29555	84756	34842604
Nocturia	31.51	15.20	41	29530	10169	34917191
Cough	31.44	15.20	49	29522	150091	34777269
Influenza	31.44	15.20	103	29468	49563	34877797
Hypokalaemia	30.65	15.20	6	29565	58208	34869152
Drug specific antibody present	30.53	15.20	24	29547	3261	34924099
Injury associated with device	30.14	15.20	16	29555	1107	34926253
Hypoglycaemia	30.13	15.20	5	29566	54635	34872725
Tremor	30.11	15.20	144	29427	82443	34844917
Concussion	29.84	15.20	21	29550	2412	34924948
Staphylococcal infection	29.44	15.20	77	29494	32683	34894677
Insomnia	28.19	15.20	167	29404	103740	34823620
Agraphia	27.91	15.20	6	29565	19	34927341
Urinary incontinence	27.79	15.20	54	29517	18820	34908540
C-reactive protein increased	27.60	15.20	6	29565	54092	34873268
Hepatic enzyme increased	27.44	15.20	84	29487	38996	34888364
Paraparesis	27.19	15.20	18	29553	1871	34925489
Headache	27.14	15.20	274	29297	200361	34726999
Nephrolithiasis	26.96	15.20	71	29500	30262	34897098
Thyroid cancer	26.62	15.20	17	29554	1663	34925697
Superficial vein prominence	26.44	15.20	5	29566	6	34927354
Progressive relapsing multiple sclerosis	26.44	15.20	5	29566	6	34927354
Multiple organ dysfunction syndrome	26.44	15.20	16	29555	76550	34850810
Muscle tightness	25.97	15.20	26	29545	4858	34922502
Gastrointestinal haemorrhage	25.96	15.20	22	29549	88455	34838905
Ankle fracture	25.78	15.20	24	29547	4101	34923259
Rhabdomyolysis	25.33	15.20	13	29558	68150	34859210
Cardiac failure	25.20	15.20	24	29547	91224	34836136
Post procedural complication	25.18	15.20	39	29532	11349	34916011
Lack of injection site rotation	25.15	15.20	9	29562	236	34927124
Frustration tolerance decreased	24.20	15.20	19	29552	2577	34924783
Ascites	24.10	15.20	5	29566	46566	34880794
Temperature intolerance	23.51	15.20	21	29550	3401	34923959
Neutrophil count decreased	23.51	15.20	7	29564	51097	34876263
Paraesthesia	23.46	15.20	112	29459	64060	34863300
Septic shock	23.45	15.20	16	29555	71818	34855542
Erectile dysfunction	23.34	15.20	53	29518	20584	34906776
COVID-19	23.09	15.20	19	29552	77531	34849829
Injection site atrophy	22.89	15.20	6	29565	52	34927308
Neuropathy peripheral	22.87	15.20	22	29549	83241	34844119
Ophthalmoplegia	22.84	15.20	16	29555	1824	34925536
Diabetes mellitus	22.65	15.20	89	29482	46784	34880576
Hospitalisation	22.45	15.20	10	29561	56892	34870468
Osteonecrosis	22.41	15.20	43	29528	14847	34912513
Suicidal ideation	22.27	15.20	80	29491	40308	34887052
Feeling abnormal	22.13	15.20	109	29462	63126	34864234
Cardiac valve rupture	22.07	15.20	4	29567	3	34927357
Dysgraphia	21.88	15.20	17	29554	2270	34925090
Injection site inflammation	21.63	15.20	12	29559	906	34926454
Chronic lymphocytic leukaemia	21.53	15.20	22	29549	4210	34923150
Rectal haemorrhage	21.50	15.20	4	29567	40245	34887115
Intentional product misuse	21.44	15.20	6	29565	45605	34881755
Intentional product use issue	21.36	15.20	12	29559	59804	34867556
Cardio-respiratory arrest	21.36	15.20	10	29561	55263	34872097
Injection site mass	21.06	15.20	27	29544	6599	34920761
Sensory disturbance	20.95	15.20	26	29545	6151	34921209
Injection site ulcer	20.91	15.20	8	29563	254	34927106
Injection site injury	20.85	15.20	8	29563	256	34927104
Weight increased	20.79	15.20	29	29542	93004	34834356
Pruritus	20.69	15.20	57	29514	141924	34785436
Diplegia	20.66	15.20	12	29559	989	34926371
Neurofibroma	20.64	15.20	4	29567	6	34927354
Hepatic function abnormal	20.55	15.20	6	29565	44357	34883003
Hip arthroplasty	20.49	15.20	22	29549	4457	34922903
Epistaxis	20.35	15.20	12	29559	58239	34869121
Mood swings	20.25	15.20	29	29542	7872	34919488
Feeling cold	20.20	15.20	34	29537	10605	34916755
Overweight	20.18	15.20	15	29556	1875	34925485
Anger	19.99	15.20	36	29535	11848	34915512
Intervertebral disc disorder	19.97	15.20	15	29556	1905	34925455
Productive cough	19.68	15.20	4	29567	37809	34889551
Lactic acidosis	19.58	15.20	3	29568	34769	34892591
Vomiting	19.54	15.20	126	29445	247495	34679865
Stomatitis	19.23	15.20	6	29565	42508	34884852
JC polyomavirus test positive	18.90	15.20	10	29561	687	34926673
Overdose	18.78	15.20	30	29541	91029	34836331
Hernia	18.70	15.20	31	29540	9552	34917808
Glioblastoma multiforme	18.36	15.20	10	29561	728	34926632
Hypoxia	18.35	15.20	12	29559	55083	34872277
Therapeutic product effect incomplete	18.24	15.20	10	29561	50531	34876829
B-cell lymphoma stage I	18.23	15.20	3	29568	0	34927360
Neutralising antibodies	18.23	15.20	3	29568	0	34927360
Fear of injection	18.12	15.20	13	29558	1539	34925821
Urosepsis	18.09	15.20	36	29535	12763	34914597
Injection site irritation	17.92	15.20	12	29559	1271	34926089
Surgery	17.87	15.20	38	29533	14119	34913241
Completed suicide	17.84	15.20	35	29536	98133	34829227
Vein disorder	17.57	15.20	12	29559	1313	34926047
Oxygen saturation decreased	17.55	15.20	12	29559	53806	34873554
Mood altered	17.52	15.20	29	29542	8923	34918437
Blindness	17.52	15.20	39	29532	14947	34912413
Blood creatine phosphokinase increased	17.51	15.20	8	29563	44849	34882511
Vaccination complication	17.03	15.20	5	29566	68	34927292
Scar	17.00	15.20	23	29548	5921	34921439
Injection site pruritus	16.98	15.20	25	29546	6958	34920402
Peripheral swelling	16.96	15.20	24	29547	76517	34850843
Depressed mood	16.94	15.20	45	29526	19272	34908088
Brain neoplasm	16.91	15.20	17	29554	3192	34924168
Pneumonitis	16.79	15.20	4	29567	33874	34893486
Somnolence	16.64	15.20	44	29527	111072	34816288
Vision blurred	16.63	15.20	80	29491	45883	34881477
Oedema	16.58	15.20	9	29562	45732	34881628
Sarcoidosis	16.52	15.20	16	29555	2872	34924488
Back disorder	16.45	15.20	24	29547	6627	34920733
Thrombocytopenic purpura	16.42	15.20	11	29560	1166	34926194
Cholelithiasis	16.30	15.20	47	29524	21101	34906259
Injection site discolouration	16.28	15.20	12	29559	1481	34925879
Blood cholesterol increased	16.17	15.20	46	29525	20497	34906863
Anal incontinence	16.14	15.20	26	29545	7823	34919537
Procedural pain	15.93	15.20	20	29551	4786	34922574
Umbilical cord around neck	15.76	15.20	6	29565	188	34927172
Appendicitis perforated	15.74	15.20	13	29558	1895	34925465
Diplopia	15.55	15.20	40	29531	16803	34910557
General physical health deterioration	15.51	15.20	56	29515	128213	34799147
Therapeutic response decreased	15.47	15.20	3	29568	29310	34898050
Injection site dryness	15.22	15.20	4	29567	35	34927325
Wheezing	15.22	15.20	8	29563	41394	34885966

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Multiple sclerosis relapse	8676.84	11.57	2984	103317	43549	79594538
Influenza like illness	4271.13	11.57	2025	104276	69682	79568405
Fall	1019.11	11.57	2097	104204	485532	79152555
Gait disturbance	757.43	11.57	1142	105159	206364	79431723
Off label use	747.40	11.57	152	106149	907063	78731024
General symptom	719.15	11.57	224	106077	2310	79635777
Breast cancer	704.19	11.57	481	105820	33300	79604787
Central nervous system lesion	576.57	11.57	304	105997	13064	79625023
Urinary tract infection	549.57	11.57	1162	105139	273350	79364737
Balance disorder	523.55	11.57	652	105649	98205	79539882
Optic neuritis	508.11	11.57	250	106051	9270	79628817
Injection site pain	488.03	11.57	725	105576	129113	79508974
Depression	477.63	11.57	955	105346	215835	79422252
Memory impairment	474.19	11.57	661	105640	111073	79527014
Injection site erythema	464.96	11.57	547	105754	77650	79560437
Hypoaesthesia	446.27	11.57	832	105469	178520	79459567
Toxicity to various agents	436.69	11.57	33	106268	421507	79216580
Seizure	384.00	11.57	805	105496	188029	79450058
Loss of control of legs	380.29	11.57	130	106171	1835	79636252
Intervertebral disc protrusion	361.45	11.57	279	106022	23342	79614745
Drug interaction	331.64	11.57	74	106227	415109	79222978
Diarrhoea	313.55	11.57	431	105870	880058	78758029
Acute kidney injury	311.29	11.57	152	106149	519252	79118835
Gait inability	298.07	11.57	380	105921	58537	79579550
Muscular weakness	292.11	11.57	655	105646	160074	79478013
Muscle spasticity	290.67	11.57	236	106065	21239	79616848
Secondary progressive multiple sclerosis	288.34	11.57	97	106204	1300	79636787
Magnetic resonance imaging abnormal	269.26	11.57	118	106183	3341	79634746
Injection site bruising	267.46	11.57	301	106000	40701	79597386
Febrile neutropenia	257.40	11.57	12	106289	230987	79407100
Decubitus ulcer	254.75	11.57	192	106109	15495	79622592
Uterine leiomyoma	240.07	11.57	133	106168	6310	79631777
Myocardial infarction	233.17	11.57	654	105647	183475	79454612
Product use in unapproved indication	231.89	11.57	30	106271	250329	79387758
Product use issue	227.14	11.57	13	106288	209809	79428278
Injection site haemorrhage	222.99	11.57	228	106073	27642	79610445
Dyspnoea	222.20	11.57	511	105790	856514	78781573
Hysterectomy	216.13	11.57	123	106178	6149	79631938
Neutropenia	214.58	11.57	59	106242	287651	79350436
Ankle fracture	214.01	11.57	179	106122	16790	79621297
Rash	213.64	11.57	275	106026	578083	79060004
Stress	209.91	11.57	379	105922	79233	79558854
Trigeminal neuralgia	205.25	11.57	99	106202	3510	79634577
Injection site infection	200.34	11.57	84	106217	2128	79635959
Coronary artery occlusion	200.31	11.57	165	106136	15150	79622937
Drug ineffective	200.17	11.57	755	105546	1080158	78557929
Injection site reaction	199.98	11.57	302	105999	54483	79583604
Injection site cellulitis	194.21	11.57	76	106225	1602	79636485
Abortion spontaneous	189.67	11.57	215	106086	29292	79608795
Contraindicated product administered	186.51	11.57	5	106296	157533	79480554
Progressive multiple sclerosis	183.94	11.57	67	106234	1150	79636937
Synovitis	181.45	11.57	4	106297	150730	79487357
Road traffic accident	180.10	11.57	255	106046	43409	79594678
Musculoskeletal disorder	172.56	11.57	176	106125	21272	79616815
Breast cancer female	172.32	11.57	134	106167	11327	79626760
Injection site abscess	171.39	11.57	69	106232	1571	79636516
Completed suicide	171.28	11.57	57	106244	245710	79392377
Relapsing-remitting multiple sclerosis	166.00	11.57	66	106235	1453	79636634
Mobility decreased	160.53	11.57	440	105861	121735	79516352
Therapeutic product effect incomplete	158.91	11.57	7	106294	141638	79496449
Hypotension	158.71	11.57	213	106088	440104	79197983
Cerebrovascular accident	158.19	11.57	511	105790	154781	79483306
Infusion related reaction	155.94	11.57	56	106245	230181	79407906
Malignant neoplasm progression	154.97	11.57	6	106295	135984	79502103
Drug abuse	154.26	11.57	18	106283	162673	79475414
Muscle spasms	154.25	11.57	548	105753	174182	79463905
Coordination abnormal	152.05	11.57	149	106152	17163	79620924
Chills	150.51	11.57	513	105788	159721	79478366
Abdominal pain	148.07	11.57	181	106120	389388	79248699
Urinary incontinence	145.73	11.57	223	106078	40686	79597401
Bladder disorder	144.00	11.57	110	106191	9055	79629032
Hip fracture	142.44	11.57	190	106111	30571	79607516
Pancytopenia	141.65	11.57	25	106276	165720	79472367
Injection site haematoma	138.27	11.57	84	106217	4743	79633344
Peroneal nerve palsy	137.73	11.57	91	106210	5951	79632136
Cystitis	136.37	11.57	249	106052	52483	79585604
Hyponatraemia	135.31	11.57	35	106266	177813	79460274
Rheumatoid arthritis	134.03	11.57	55	106246	208415	79429672
Injection site necrosis	133.43	11.57	56	106245	1422	79636665
Joint swelling	132.44	11.57	114	106187	288532	79349555
Thyroid cancer	131.86	11.57	86	106215	5502	79632585
Stomatitis	130.17	11.57	20	106281	146737	79491350
Caesarean section	129.41	11.57	118	106183	12417	79625670
Post procedural complication	128.92	11.57	159	106142	23670	79614417
Cognitive disorder	128.02	11.57	286	106015	69640	79568447
Multiple sclerosis	127.57	11.57	153	106148	22129	79615958
Hyperkalaemia	124.03	11.57	7	106294	114391	79523696
Intentional product use issue	123.51	11.57	26	106275	152086	79486001
Head injury	121.03	11.57	195	106106	37174	79600913
Blood creatinine increased	120.89	11.57	29	106272	155028	79483059
C-reactive protein increased	120.52	11.57	15	106286	129012	79509075
Lower limb fracture	117.77	11.57	150	106151	23065	79615022
Nausea	117.26	11.57	772	105529	956424	78681663
Breast cancer in situ	117.13	11.57	45	106256	901	79637186
Anaemia	116.81	11.57	263	106038	444752	79193335
Neurogenic bladder	114.78	11.57	71	106230	4141	79633946
Upper limb fracture	110.54	11.57	128	106173	17839	79620248
Thrombocytopenia	109.69	11.57	115	106186	265144	79372943
Cough	109.65	11.57	201	106100	366588	79271499
Needle fatigue	108.45	11.57	42	106259	860	79637227
Injection site scar	108.08	11.57	41	106260	792	79637295
Peripheral swelling	106.95	11.57	121	106180	269496	79368591
General physical health deterioration	106.50	11.57	126	106175	275112	79362975
Glossodynia	101.60	11.57	10	106291	103327	79534760
Dysstasia	101.29	11.57	153	106148	27593	79610494
Gait spastic	100.24	11.57	43	106258	1154	79636933
Drug hypersensitivity	98.34	11.57	154	106147	298762	79339325
Diabetes mellitus	97.68	11.57	277	106024	78113	79559974
Pruritus	97.32	11.57	241	106060	394407	79243680
Decreased appetite	96.79	11.57	194	106107	342224	79295863
Visual impairment	95.41	11.57	305	105996	91826	79546261
Therapeutic product effect decreased	94.84	11.57	50	106251	163813	79474274
Interstitial lung disease	94.00	11.57	18	106283	112582	79525505
Tremor	93.14	11.57	461	105840	169622	79468465
Asthenia	92.76	11.57	1066	105235	510623	79127464
Cholelithiasis	91.50	11.57	211	106090	52453	79585634
Electrocardiogram QT prolonged	90.85	11.57	8	106293	90378	79547709
Amnesia	90.77	11.57	235	106066	62822	79575265
Nephrolithiasis	89.83	11.57	211	106090	53080	79585007
Invasive ductal breast carcinoma	88.81	11.57	69	106232	5823	79632264
Hemiparesis	88.11	11.57	160	106141	33573	79604514
Abdominal discomfort	87.48	11.57	124	106177	250603	79387484
Treatment failure	86.16	11.57	61	106240	170425	79467662
Adverse drug reaction	85.06	11.57	237	106064	66155	79571932
Micturition urgency	84.46	11.57	94	106207	12547	79625540
Malignant melanoma	84.02	11.57	101	106200	14640	79623447
Intracranial aneurysm	83.59	11.57	60	106241	4490	79633597
Ovarian cancer	81.88	11.57	56	106245	3878	79634209
Lower respiratory tract infection	81.57	11.57	35	106266	129185	79508902
Renal impairment	80.34	11.57	56	106245	157727	79480360
Anxiety	79.82	11.57	586	105715	247926	79390161
Hypokalaemia	78.96	11.57	47	106254	143993	79494094
Staphylococcal infection	78.56	11.57	212	106089	58083	79580004
Haemoglobin decreased	78.33	11.57	109	106192	222010	79416077
Psoriatic arthropathy	78.13	11.57	7	106294	77992	79560095
Mucosal inflammation	77.87	11.57	6	106295	75574	79562513
Blindness unilateral	76.98	11.57	73	106228	8073	79630014
Injection site mass	76.10	11.57	113	106188	20071	79618016
Metabolic acidosis	76.08	11.57	10	106291	82519	79555568
Migraine	75.92	11.57	273	106028	87220	79550867
Pericarditis	74.64	11.57	23	106278	104213	79533874
Injection site induration	74.33	11.57	78	106223	9741	79628346
Drug delivery device placement	74.09	11.57	22	106279	190	79637897
Multiple organ dysfunction syndrome	73.64	11.57	34	106267	120212	79517875
Hypoglycaemia	73.51	11.57	22	106279	101572	79536515
Oedema	72.94	11.57	34	106267	119546	79518541
Neuromyelitis optica spectrum disorder	72.94	11.57	33	106268	1009	79637078
Dyspnoea exertional	72.51	11.57	14	106287	87059	79551028
Kidney infection	72.09	11.57	115	106186	21736	79616351
Pleural effusion	72.06	11.57	53	106248	145209	79492878
Intentional product misuse	71.84	11.57	19	106282	95146	79542941
Wheezing	71.43	11.57	33	106268	116631	79521456
Tachycardia	71.31	11.57	79	106222	177689	79460398
Platelet count decreased	71.19	11.57	93	106208	194571	79443516
Sensory disturbance	71.14	11.57	94	106207	14983	79623104
Oxygen saturation decreased	70.88	11.57	42	106259	129005	79509082
Gastrointestinal haemorrhage	69.34	11.57	57	106244	147662	79490425
Gastric bypass	68.92	11.57	34	106267	1267	79636820
Lactic acidosis	68.66	11.57	7	106294	70352	79567735
Paraesthesia	68.63	11.57	436	105865	175887	79462200
Neutrophil count decreased	68.61	11.57	20	106281	93939	79544148
Melaena	68.30	11.57	3	106298	60887	79577200
Concussion	67.54	11.57	73	106228	9430	79628657
Generalised tonic-clonic seizure	66.67	11.57	167	106134	43743	79594344
Loss of personal independence in daily activities	66.00	11.57	27	106274	102553	79535534
Ataxia	65.69	11.57	119	106182	24920	79613167
Speech disorder	65.49	11.57	190	106111	54255	79583832
Procedural pain	64.79	11.57	113	106188	22971	79615116
COVID-19	64.42	11.57	69	106232	157605	79480482
Injury associated with device	63.87	11.57	46	106255	3460	79634627
Intentional overdose	63.29	11.57	31	106270	105929	79532158
Hypertension	63.23	11.57	697	105604	330295	79307792
Lumbar spinal stenosis	63.06	11.57	54	106247	5228	79632859
Helicobacter infection	62.94	11.57	9	106292	69695	79568392
Endometriosis	62.01	11.57	46	106255	3622	79634465
International normalised ratio increased	61.92	11.57	18	106283	84703	79553384
Intervertebral disc disorder	61.04	11.57	51	106250	4774	79633313
Respiratory failure	60.61	11.57	92	106209	180819	79457268
Intervertebral disc degeneration	60.41	11.57	89	106212	15696	79622391
Scar	60.07	11.57	87	106214	15109	79622978
Appendicitis perforated	59.99	11.57	43	106258	3210	79634877
Therapeutic response decreased	59.51	11.57	9	106292	66844	79571243
Procedural anxiety	59.19	11.57	26	106275	740	79637347
Hypertonic bladder	58.60	11.57	47	106254	4154	79633933
Arthralgia	58.32	11.57	485	105816	571318	79066769
Bipolar disorder	57.95	11.57	61	106240	7646	79630441
Drug specific antibody present	57.94	11.57	57	106244	6595	79631492
Cardiac failure	57.62	11.57	73	106228	154769	79483318
Spinal stenosis	57.53	11.57	87	106214	15704	79622383
Injection site ulcer	57.49	11.57	25	106276	694	79637393
Headache	56.50	11.57	1202	105099	652570	78985517
Paraparesis	56.16	11.57	44	106257	3759	79634328
Temperature intolerance	56.14	11.57	67	106234	9638	79628449
Rhabdomyolysis	56.03	11.57	34	106267	103097	79534990
Cardio-respiratory arrest	55.91	11.57	38	106263	108472	79529615
Breast cancer stage I	55.75	11.57	56	106245	6644	79631443
Productive cough	55.62	11.57	24	106277	88307	79549780
Cervical spinal stenosis	54.91	11.57	36	106265	2323	79635764
Hypoxia	54.75	11.57	35	106266	103208	79534879
Influenza	54.51	11.57	327	105974	129279	79508808
Feeling abnormal	54.31	11.57	381	105920	158818	79479269
Thrombosis	54.11	11.57	239	106062	83861	79554226
Overdose	54.04	11.57	102	106199	184104	79453983
Lung neoplasm malignant	53.48	11.57	116	106185	27676	79610411
Blood pressure systolic increased	53.24	11.57	12	106289	66974	79571113
Intraductal proliferative breast lesion	53.13	11.57	36	106265	2455	79635632
Monoparesis	52.67	11.57	41	106260	3470	79634617
Blister	52.56	11.57	49	106252	119427	79518660
Vomiting	52.24	11.57	602	105699	665226	78972861
Injection site atrophy	52.03	11.57	20	106281	401	79637686
Ligament rupture	51.71	11.57	40	106261	3354	79634733
Meningioma benign	51.46	11.57	18	106283	273	79637814
Paralysis	51.45	11.57	75	106226	13102	79624985
Hypocalcaemia	51.32	11.57	4	106297	49920	79588167
Surgery	51.20	11.57	126	106175	32640	79605447
Psoriasis	50.85	11.57	28	106273	89559	79548528
Tibia fracture	50.58	11.57	48	106253	5313	79632774
Hypomagnesaemia	50.44	11.57	3	106298	46908	79591179
Hospitalisation	49.90	11.57	32	106269	94204	79543883
Septic shock	49.87	11.57	54	106247	122747	79515340
Dysgraphia	49.73	11.57	42	106259	3990	79634097
Folliculitis	48.07	11.57	8	106293	55372	79582715
Postoperative wound infection	48.06	11.57	72	106229	12889	79625198
Disease progression	47.42	11.57	110	106191	184252	79453835
Gallbladder disorder	47.07	11.57	89	106212	19251	79618836
Ascites	46.83	11.57	21	106280	75541	79562546
Cervix carcinoma	46.72	11.57	32	106269	2221	79635866
Blood creatine phosphokinase increased	46.57	11.57	15	106286	66075	79572012
Pain in extremity	46.16	11.57	712	105589	363826	79274261
Basedow's disease	45.78	11.57	16	106285	242	79637845
Nerve compression	45.76	11.57	59	106242	9180	79628907
Maternal exposure timing unspecified	45.62	11.57	47	106254	5745	79632342
Cellulitis	45.11	11.57	274	106027	108786	79529301
Haematochezia	44.74	11.57	31	106270	87614	79550473
Systemic lupus erythematosus	44.15	11.57	58	106243	121091	79516996
Dysarthria	44.12	11.57	193	106108	67429	79570658
Neutralising antibodies positive	43.90	11.57	16	106285	275	79637812
Injection site irritation	43.73	11.57	38	106263	3752	79634335
Fatigue	43.59	11.57	1580	104721	928147	78709940
Nasal congestion	43.34	11.57	24	106277	76528	79561559
Feeling cold	43.33	11.57	109	106192	28620	79609467
Depressed level of consciousness	43.27	11.57	39	106262	96613	79541474
Vision blurred	43.14	11.57	265	106036	105633	79532454
Meniscus injury	42.95	11.57	49	106252	6719	79631368
Pulmonary thrombosis	42.84	11.57	66	106235	12105	79625982
Papillary thyroid cancer	42.75	11.57	32	106269	2554	79635533
Pregnancy	42.75	11.57	104	106197	26747	79611340
Fibula fracture	42.72	11.57	37	106264	3637	79634450
Muscle tightness	42.64	11.57	68	106233	12846	79625241
Serotonin syndrome	42.61	11.57	5	106296	45022	79593065
Foot fracture	42.58	11.57	92	106209	21889	79616198
Neuropathy peripheral	42.54	11.57	77	106224	141228	79496859
Muscle injury	42.18	11.57	7	106294	48554	79589533
Swelling	41.99	11.57	148	106153	216563	79421524
Cholecystectomy	41.74	11.57	57	106244	9375	79628712
Diplopia	41.42	11.57	118	106183	33348	79604739
Somnolence	41.28	11.57	171	106130	238810	79399277
Medication error	41.11	11.57	20	106281	68622	79569465
Back disorder	41.06	11.57	63	106238	11515	79626572
Constipation	40.95	11.57	216	106085	282834	79355253
Pollakiuria	40.87	11.57	126	106175	37191	79600896
Rash maculo-papular	40.82	11.57	12	106289	56066	79582021
Primary progressive multiple sclerosis	40.69	11.57	12	106289	101	79637986
Lack of injection site rotation	40.35	11.57	18	106283	532	79637555
Drug intolerance	40.22	11.57	198	106103	263921	79374166
Injection site scab	40.21	11.57	16	106285	353	79637734
Injection site inflammation	40.20	11.57	37	106264	3939	79634148
Focal dyscognitive seizures	40.10	11.57	35	106266	3477	79634610
Drug dependence	39.92	11.57	4	106297	40765	79597322
Sedation	39.85	11.57	10	106291	51885	79586202
Cytomegalovirus infection	39.70	11.57	5	106296	42639	79595448
Movement disorder	39.64	11.57	102	106199	27157	79610930
Ovarian cyst	39.56	11.57	65	106236	12590	79625497
Mammoplasty	39.48	11.57	15	106286	291	79637796
Knee arthroplasty	39.27	11.57	137	106164	43111	79594976
Pneumonitis	39.17	11.57	16	106285	60844	79577243
Appendicitis	39.11	11.57	86	106215	20708	79617379
Erythema	39.05	11.57	159	106142	223131	79414956
Haemorrhage in pregnancy	38.95	11.57	24	106277	1390	79636697
Agraphia	38.88	11.57	10	106291	47	79638040
Breast cancer recurrent	38.77	11.57	32	106269	2945	79635142
Upper gastrointestinal haemorrhage	38.17	11.57	5	106296	41375	79596712
Bradycardia	38.07	11.57	77	106224	135480	79502607
Burning sensation	37.99	11.57	167	106134	58465	79579622
Glioblastoma	37.83	11.57	25	106276	1635	79636452
Meningioma	37.75	11.57	37	106264	4261	79633826
Wound infection staphylococcal	37.24	11.57	32	106269	3112	79634975
Benign lung neoplasm	37.15	11.57	11	106290	94	79637993
Rotator cuff syndrome	36.99	11.57	67	106234	14028	79624059
Ruptured cerebral aneurysm	36.80	11.57	17	106284	546	79637541
Retinal exudates	36.68	11.57	22	106279	1213	79636874
Urosepsis	36.34	11.57	97	106204	26398	79611689
Agranulocytosis	35.92	11.57	8	106293	45022	79593065
Suicidal ideation	35.60	11.57	198	106103	76142	79561945
Incorrect dose administered	35.42	11.57	30	106271	76600	79561487
Rectal haemorrhage	35.11	11.57	30	106271	76270	79561817
Procedural complication	34.96	11.57	48	106253	7935	79630152
Endometrial cancer	34.82	11.57	26	106275	2068	79636019
Brain neoplasm benign	34.74	11.57	12	106289	175	79637912
Appendicectomy	34.67	11.57	29	106272	2719	79635368
Delirium	34.59	11.57	37	106264	84590	79553497
Thyroid disorder	34.52	11.57	65	106236	14014	79624073
Colon cancer	34.32	11.57	66	106235	14457	79623630
Agitation	34.07	11.57	50	106251	99665	79538422
Spinal disorder	33.84	11.57	54	106247	10206	79627881
Drug ineffective for unapproved indication	33.75	11.57	13	106288	51225	79586862
Bone marrow failure	33.61	11.57	13	106288	51094	79586993
Prolonged labour	33.32	11.57	15	106286	453	79637634
Breech presentation	33.23	11.57	17	106284	685	79637402
Hypervolaemia	33.22	11.57	8	106293	42682	79595405
Thyroid neoplasm	33.08	11.57	30	106271	3134	79634953
Haematuria	32.99	11.57	26	106275	68810	79569277
Uterine cancer	32.84	11.57	32	106269	3659	79634428
Mental impairment	32.76	11.57	76	106225	18960	79619127
Alopecia	32.65	11.57	178	106123	231177	79406910
Facial bones fracture	32.60	11.57	37	106264	5045	79633042
Myelosuppression	32.46	11.57	7	106294	40289	79597798
Tubulointerstitial nephritis	32.14	11.57	6	106295	38229	79599858
Vertigo	32.10	11.57	179	106122	68903	79569184
Colon cancer stage III	31.89	11.57	13	106288	306	79637781
Ligament sprain	31.58	11.57	61	106240	13403	79624684
Band sensation	31.38	11.57	17	106284	771	79637316
Diplegia	31.35	11.57	23	106278	1780	79636307
Phobia	31.13	11.57	14	106287	422	79637665
JC polyomavirus test	31.03	11.57	8	106293	38	79638049
Dry skin	30.96	11.57	27	106274	67968	79570119
Autoimmune hepatitis	30.90	11.57	56	106245	11727	79626360
Accidental exposure to product	30.86	11.57	3	106298	31319	79606768
Shock	30.47	11.57	10	106291	43538	79594549
Injection site nodule	30.36	11.57	31	106270	3749	79634338
Hernia	30.34	11.57	69	106232	16990	79621097
Mouth ulceration	30.26	11.57	7	106294	38387	79599700
Skin laceration	30.07	11.57	96	106205	28866	79609221
Cellulitis staphylococcal	30.02	11.57	19	106282	1154	79636933
Cartilage injury	29.85	11.57	21	106280	1522	79636565
Osteonecrosis	29.53	11.57	100	106201	30995	79607092
Malaise	29.45	11.57	858	105443	489011	79149076
Aphasia	29.44	11.57	132	106169	46600	79591487
Rib fracture	29.35	11.57	93	106208	27854	79610233
Wound	29.32	11.57	70	106231	116109	79521978
Injection site discolouration	29.24	11.57	43	106258	7571	79630516
Rectocele	29.19	11.57	15	106286	610	79637477
Gallbladder operation	29.18	11.57	23	106278	1982	79636105
Product administered at inappropriate site	29.13	11.57	31	106270	3934	79634153
Clostridial infection	29.10	11.57	37	106264	5677	79632410
Epistaxis	29.10	11.57	66	106235	111449	79526638
Eosinophilia	29.06	11.57	12	106289	45333	79592754
Product administration error	29.01	11.57	4	106297	31842	79606245
No adverse event	28.87	11.57	112	106189	37080	79601007
Vein disorder	28.71	11.57	35	106266	5147	79632940
Testicular infarction	28.66	11.57	8	106293	54	79638033
Cholestasis	28.55	11.57	17	106284	52092	79585995
Obstructive airways disorder	28.54	11.57	4	106297	31455	79606632
Breast cancer stage II	28.54	11.57	44	106257	8076	79630011
Blindness	28.49	11.57	93	106208	28290	79609797
Product prescribing error	28.49	11.57	12	106289	44801	79593286
Haemoptysis	28.32	11.57	20	106281	55979	79582108
Inflammation	28.29	11.57	51	106250	93702	79544385
Frustration tolerance decreased	28.28	11.57	42	106259	7460	79630627
Blood potassium decreased	28.27	11.57	130	106171	46382	79591705
Wrist fracture	27.95	11.57	54	106247	11867	79626220
Acute respiratory failure	27.90	11.57	23	106278	59518	79578569
Haemolytic uraemic syndrome	27.87	11.57	32	106269	4417	79633670
Paraplegia	27.78	11.57	34	106267	5019	79633068
Muscle atrophy	27.72	11.57	52	106249	11180	79626907
Hepatic function abnormal	27.67	11.57	34	106267	73073	79565014
Depressed mood	27.64	11.57	133	106168	48347	79589740
Abnormal labour	27.50	11.57	6	106295	11	79638076
Autoimmune thyroiditis	27.46	11.57	31	106270	4202	79633885
Cervical vertebral fracture	27.45	11.57	29	106272	3649	79634438
Benign breast neoplasm	27.29	11.57	16	106285	846	79637241
Arterial occlusive disease	27.20	11.57	44	106257	8412	79629675
Abdominal distension	27.19	11.57	76	106225	119574	79518513
Chronic lymphocytic leukaemia	27.17	11.57	33	106268	4833	79633254
Goitre	26.85	11.57	35	106266	5504	79632583
Spinal fusion surgery	26.81	11.57	34	106267	5204	79632883
Hypercalcaemia	26.59	11.57	9	106292	38421	79599666
Injection site injury	26.50	11.57	15	106286	742	79637345
Central venous catheterisation	26.47	11.57	27	106274	3262	79634825
Dry mouth	26.45	11.57	48	106253	87971	79550116
Loss of consciousness	26.43	11.57	341	105960	167602	79470485
Hip arthroplasty	26.40	11.57	106	106195	35650	79602437
Intervertebral disc operation	25.76	11.57	16	106285	940	79637147
Illness	25.72	11.57	15	106286	46496	79591591
Disseminated intravascular coagulation	25.49	11.57	8	106293	35834	79602253
Rash pruritic	25.37	11.57	35	106266	71594	79566493
Red blood cell sedimentation rate increased	25.15	11.57	15	106286	45927	79592160
Pulmonary sarcoidosis	24.93	11.57	18	106283	1359	79636728
Blood pressure diastolic decreased	24.85	11.57	5	106296	30211	79607876
Oestrogen receptor assay positive	24.85	11.57	11	106290	319	79637768
Brain neoplasm	24.80	11.57	34	106267	5612	79632475
Fractured coccyx	24.78	11.57	16	106285	1006	79637081
Varicose vein	24.73	11.57	30	106271	4389	79633698
Osteoarthritis	24.70	11.57	200	106101	87109	79550978
Epilepsy	24.68	11.57	114	106187	40746	79597341
Blood pressure fluctuation	24.61	11.57	32	106269	67113	79570974
Crohn's disease	24.47	11.57	21	106280	2039	79636048
Volvulus	24.43	11.57	24	106277	2772	79635315
Progesterone receptor assay positive	24.43	11.57	10	106291	238	79637849
Breast calcifications	24.37	11.57	15	106286	867	79637220
Angioedema	24.18	11.57	40	106261	75995	79562092
Decreased immune responsiveness	24.09	11.57	33	106268	5442	79632645
Inappropriate schedule of product administration	24.08	11.57	94	106207	133534	79504553
Post procedural stroke	23.86	11.57	8	106293	106	79637981
Therapy non-responder	23.78	11.57	55	106246	92250	79545837
Abortion missed	23.75	11.57	17	106284	1266	79636821
Coronary artery disease	23.67	11.57	159	106142	65315	79572772
Sarcoidosis	23.65	11.57	41	106260	8294	79629793
Renal cell carcinoma	23.62	11.57	36	106265	6542	79631545
Ophthalmoplegia	23.61	11.57	24	106277	2888	79635199
Cervical dysplasia	23.60	11.57	21	106280	2140	79635947
Orthostatic hypotension	23.58	11.57	24	106277	56140	79581947
Pelvic fracture	23.55	11.57	51	106250	12153	79625934
Oedema peripheral	23.43	11.57	219	106082	252069	79386018
Cholecystitis	23.40	11.57	74	106227	22138	79615949
Anal incontinence	23.40	11.57	65	106236	18103	79619984
Product quality issue	23.39	11.57	8	106293	33932	79604155
Hyperglycaemia	23.32	11.57	36	106265	70299	79567788
Mental disorder	23.28	11.57	93	106208	31209	79606878
Ectopic pregnancy	23.25	11.57	19	106282	1724	79636363
Injection site swelling	23.15	11.57	124	106177	47008	79591079
Pre-eclampsia	23.14	11.57	37	106264	7004	79631083
Panic attack	23.11	11.57	78	106223	24138	79613949
Colostomy closure	22.94	11.57	9	106292	191	79637896
Leukopenia	22.94	11.57	79	106222	116434	79521653
Skull fracture	22.90	11.57	19	106282	1761	79636326
Lung adenocarcinoma	22.73	11.57	39	106262	7825	79630262
Thermal burn	22.68	11.57	37	106264	7123	79630964
Bladder dysfunction	22.30	11.57	16	106285	1196	79636891
Fluid retention	21.95	11.57	37	106264	69772	79568315
Atrial fibrillation	21.89	11.57	164	106137	197722	79440365
Spondylolisthesis	21.88	11.57	24	106277	3151	79634936
Dyspepsia	21.87	11.57	73	106228	108614	79529473
Intervertebral disc displacement	21.62	11.57	11	106290	438	79637649
Cephalo-pelvic disproportion	21.51	11.57	8	106293	146	79637941
Anaphylactic reaction	21.49	11.57	50	106251	83693	79554394
Female genital operation	21.45	11.57	5	106296	14	79638073
Urinary tract infection staphylococcal	21.39	11.57	14	106287	901	79637186
Overweight	21.34	11.57	27	106274	4123	79633964
Femur fracture	21.29	11.57	105	106196	38547	79599540
Magnetic resonance imaging head abnormal	21.25	11.57	22	106279	2704	79635383
Incision site complication	21.25	11.57	13	106288	743	79637344
Spinal osteoarthritis	21.25	11.57	60	106241	16867	79621220
Weight increased	21.20	11.57	252	106049	277134	79360953
Ventricular tachycardia	21.18	11.57	15	106286	41920	79596167
Cardiogenic shock	21.16	11.57	15	106286	41899	79596188
Stevens-Johnson syndrome	21.14	11.57	13	106288	39153	79598934
Fear	21.14	11.57	71	106230	21915	79616172
Blood calcium decreased	21.08	11.57	8	106293	31811	79606276
Lumbar radiculopathy	20.99	11.57	19	106282	1980	79636107
Heavy menstrual bleeding	20.96	11.57	53	106248	13958	79624129
Withdrawal syndrome	20.96	11.57	5	106296	26849	79611238
Ovarian germ cell teratoma benign	20.95	11.57	6	106295	45	79638042
Renal tubular necrosis	20.90	11.57	4	106297	25035	79613052
Demyelination	20.88	11.57	38	106263	7985	79630102
Chronic kidney disease	20.86	11.57	35	106266	66119	79571968
Enterocele	20.83	11.57	6	106295	46	79638041
Post procedural haemorrhage	20.57	11.57	52	106249	13692	79624395
Ovarian cancer stage III	20.43	11.57	9	106292	258	79637829
JC polyomavirus test positive	20.40	11.57	17	106284	1585	79636502
Retinal tear	20.40	11.57	17	106284	1585	79636502
Oral candidiasis	20.39	11.57	7	106294	29621	79608466
Hepatotoxicity	20.38	11.57	23	106278	51329	79586758
Blood urea increased	20.31	11.57	21	106280	48769	79589318
Benign neoplasm of spinal cord	20.25	11.57	4	106297	3	79638084
Expanded disability status scale score increased	20.22	11.57	12	106289	649	79637438
Malignant hypertension	20.22	11.57	17	106284	1605	79636482
Clavicle fracture	20.18	11.57	27	106274	4354	79633733
Conversion disorder	20.15	11.57	18	106283	1843	79636244
Arthritis	20.11	11.57	238	106063	114642	79523445
Atrophy	20.08	11.57	19	106282	2095	79635992
Fibrocystic breast disease	20.07	11.57	12	106289	658	79637429
Myoclonus	19.98	11.57	6	106295	27654	79610433
Rectal cancer	19.90	11.57	24	106277	3489	79634598
Glioblastoma multiforme	19.87	11.57	15	106286	1213	79636874
Prescribed overdose	19.86	11.57	13	106288	37870	79600217
Polyneuropathy	19.86	11.57	4	106297	24147	79613940
Bronchopulmonary aspergillosis	19.84	11.57	3	106298	22291	79615796
Raynaud's phenomenon	19.79	11.57	14	106287	1024	79637063
Tachypnoea	19.73	11.57	9	106292	32054	79606033
Cholecystitis infective	19.70	11.57	22	106279	2947	79635140
Fat necrosis	19.67	11.57	13	106288	850	79637237
Patella fracture	19.66	11.57	18	106283	1903	79636184
Insomnia	19.55	11.57	446	105855	244724	79393363
Vaccination complication	19.54	11.57	13	106288	860	79637227
Endometrial cancer stage I	19.52	11.57	8	106293	191	79637896
Accident	19.49	11.57	39	106262	8792	79629295
Limb mass	19.44	11.57	24	106277	3575	79634512
Restlessness	19.36	11.57	20	106281	46472	79591615
Cardiac arrest	19.33	11.57	142	106159	171954	79466133
Neuralgia	19.33	11.57	92	106209	33292	79604795
Medical induction of coma	19.28	11.57	7	106294	119	79637968
Motor dysfunction	19.26	11.57	53	106248	14680	79623407
Post procedural infection	19.10	11.57	45	106256	11339	79626748
Right ventricular failure	19.09	11.57	4	106297	23493	79614594
Oropharyngeal pain	19.02	11.57	78	106223	109275	79528812
Schwannoma	19.01	11.57	7	106294	124	79637963
Nerve injury	18.99	11.57	40	106261	9352	79628735
Scoliosis	18.98	11.57	35	106266	7429	79630658
Throat irritation	18.96	11.57	16	106285	40930	79597157
Liver function test abnormal	18.95	11.57	149	106152	64326	79573761
Fear of injection	18.94	11.57	35	106266	7439	79630648
Feeling of body temperature change	18.91	11.57	29	106272	5297	79632790
Urinary bladder suspension	18.86	11.57	7	106294	127	79637960
Cardiac valve rupture	18.83	11.57	4	106297	6	79638081
Rectal cancer stage I	18.83	11.57	4	106297	6	79638081
Poor venous access	18.70	11.57	60	106241	18089	79619998
Irritable bowel syndrome	18.65	11.57	34	106267	62207	79575880
Injection site calcification	18.56	11.57	5	106296	29	79638058
Carotid artery aneurysm	18.43	11.57	9	106292	328	79637759
Limb injury	18.29	11.57	83	106218	29445	79608642
Gun shot wound	18.29	11.57	14	106287	1156	79636931
Injection site thrombosis	18.27	11.57	7	106294	139	79637948
Back injury	18.09	11.57	42	106259	10481	79627606
Arthropathy	18.09	11.57	150	106151	176961	79461126
Ventricular fibrillation	18.08	11.57	10	106291	31916	79606171
Haematemesis	18.05	11.57	26	106275	52238	79585849
Reaction to preservatives	17.98	11.57	8	106293	235	79637852
Oral pain	17.95	11.57	10	106291	31788	79606299
Precancerous cells present	17.90	11.57	14	106287	1193	79636894
Breast cancer metastatic	17.81	11.57	37	106264	8565	79629522
Colon cancer metastatic	17.73	11.57	18	106283	2163	79635924
Bladder prolapse	17.70	11.57	15	106286	1432	79636655
Lung adenocarcinoma stage I	17.64	11.57	5	106296	36	79638051
Skin graft	17.63	11.57	13	106288	1014	79637073
Crying	17.57	11.57	69	106232	22974	79615113
Uterine disorder	17.55	11.57	18	106283	2189	79635898
Rhinorrhoea	17.52	11.57	48	106253	76026	79562061
Adrenal insufficiency	17.52	11.57	8	106293	28479	79609608
Heat stroke	17.52	11.57	16	106285	1687	79636400
Skin exfoliation	17.51	11.57	29	106272	55071	79583016
Injection site fibrosis	17.49	11.57	4	106297	10	79638077
Full blood count decreased	17.34	11.57	7	106294	26812	79611275
Foetal heart rate abnormal	17.31	11.57	9	106292	375	79637712
Progressive relapsing multiple sclerosis	17.29	11.57	5	106296	39	79638048
Pulmonary oedema	17.26	11.57	60	106241	88194	79549893
Female sterilisation	17.26	11.57	8	106293	259	79637828
Lipoatrophy	17.23	11.57	11	106290	678	79637409
Optic nerve disorder	17.20	11.57	14	106287	1263	79636824
Haemophagocytic lymphohistiocytosis	17.17	11.57	4	106297	21833	79616254
Arthroscopy	17.14	11.57	10	106291	524	79637563
Rales	17.11	11.57	3	106298	19998	79618089
Endometrial adenocarcinoma	17.10	11.57	13	106288	1062	79637025
Emotional disorder	17.10	11.57	50	106251	14337	79623750
Lung disorder	16.97	11.57	53	106248	80504	79557583
Anaesthetic complication	16.97	11.57	20	106281	2839	79635248
Non-small cell lung cancer stage I	16.96	11.57	4	106297	12	79638075
Uterine leiomyosarcoma	16.96	11.57	4	106297	12	79638075
Invasive lobular breast carcinoma	16.92	11.57	11	106290	700	79637387
Visual acuity reduced	16.91	11.57	81	106220	29388	79608699
Alpha-1 anti-trypsin increased	16.87	11.57	3	106298	0	79638087
Neurological complication associated with device	16.87	11.57	3	106298	0	79638087
Biopsy bladder	16.87	11.57	3	106298	0	79638087
Benign uterine neoplasm	16.87	11.57	3	106298	0	79638087
Gastric cyst	16.86	11.57	6	106295	96	79637991
Knee operation	16.83	11.57	29	106272	5837	79632250
Inappropriate antidiuretic hormone secretion	16.80	11.57	7	106294	26306	79611781
Encephalopathy	16.69	11.57	41	106260	67356	79570731
Intervertebral disc injury	16.60	11.57	7	106294	180	79637907
Eczema	16.51	11.57	18	106283	40800	79597287
Amniotic fluid volume decreased	16.47	11.57	8	106293	288	79637799
Discomfort	16.44	11.57	99	106202	125518	79512569
Calculus bladder	16.32	11.57	14	106287	1358	79636729
Febrile convulsion	16.30	11.57	12	106289	934	79637153
Incision site abscess	16.20	11.57	9	106292	429	79637658
Urinary retention postoperative	16.18	11.57	7	106294	192	79637895
Complication of delivery	16.16	11.57	6	106295	109	79637978
Hallucination, visual	16.14	11.57	12	106289	32717	79605370
Hepatocellular injury	16.12	11.57	24	106277	47569	79590518
Abdominal pain upper	16.09	11.57	206	106095	223613	79414474
Rash erythematous	16.05	11.57	33	106268	57736	79580351
Reproductive tract disorder	16.01	11.57	5	106296	52	79638035
Cast application	15.88	11.57	4	106297	17	79638070
Toxic skin eruption	15.81	11.57	5	106296	22288	79615799
Skin cancer	15.75	11.57	50	106251	14990	79623097
Nocturia	15.74	11.57	47	106254	13634	79624453
Serum serotonin decreased	15.69	11.57	4	106297	18	79638069
Frequent bowel movements	15.67	11.57	10	106291	29529	79608558
Incontinence	15.67	11.57	48	106253	14116	79623971
Cardiac disorder	15.65	11.57	145	106156	65612	79572475
Hand fracture	15.59	11.57	29	106272	6196	79631891
Liver function test increased	15.58	11.57	18	106283	39755	79598332
Meningitis viral	15.42	11.57	16	106285	1972	79636115
Product substitution issue	15.37	11.57	4	106297	20252	79617835
Spinal fracture	15.37	11.57	56	106245	17998	79620089
Heat exhaustion	15.22	11.57	8	106293	341	79637746
Neurofibroma	15.18	11.57	4	106297	21	79638066
Pulmonary fibrosis	15.18	11.57	22	106279	44090	79593997
Uterine mass	15.03	11.57	7	106294	229	79637858
Altered state of consciousness	14.94	11.57	22	106279	43800	79594287
Pain in jaw	14.94	11.57	24	106277	46127	79591960
Relapsing multiple sclerosis	14.93	11.57	6	106295	136	79637951
Umbilical cord around neck	14.88	11.57	4	106297	23	79638064
Dystonia	14.82	11.57	5	106296	21394	79616693
Hyperthermia	14.80	11.57	3	106298	18034	79620053
Cystitis pseudomonal	14.79	11.57	3	106298	3	79638084
Lhermitte's sign	14.79	11.57	3	106298	3	79638084
Ovarian adenoma	14.78	11.57	7	106294	238	79637849
Dysgeusia	14.78	11.57	34	106267	57143	79580944
Medical device removal	14.72	11.57	10	106291	685	79637402
Hypoalbuminaemia	14.71	11.57	5	106296	21292	79616795
Animal bite	14.69	11.57	18	106283	2661	79635426
Cervical incompetence	14.66	11.57	9	106292	518	79637569
Spinal cord disorder	14.65	11.57	15	106286	1820	79636267
Eye disorder	14.65	11.57	66	106235	23346	79614741
Bone erosion	14.58	11.57	3	106298	17844	79620243
Purpura	14.54	11.57	4	106297	19523	79618564
Cervix carcinoma stage 0	14.52	11.57	7	106294	248	79637839
Hepatic steatosis	14.46	11.57	93	106208	37645	79600442
Facial paralysis	14.40	11.57	61	106240	21011	79617076
Injection site hypoaesthesia	14.39	11.57	9	106292	535	79637552
Ocular hyperaemia	14.36	11.57	10	106291	28196	79609891
Anuria	14.34	11.57	5	106296	20958	79617129
B-cell lymphoma stage I	14.33	11.57	3	106298	4	79638083
Staphylococcal abscess	14.33	11.57	12	106289	1127	79636960
Basal cell carcinoma	14.26	11.57	92	106209	37283	79600804
Contusion	14.24	11.57	278	106023	148498	79489589
Bronchiectasis	14.22	11.57	6	106295	22380	79615707
Dry eye	14.16	11.57	17	106284	36914	79601173
Viral infection	14.10	11.57	102	106199	42914	79595173
Drug eruption	14.08	11.57	23	106278	43912	79594175
Viral pericarditis	14.05	11.57	5	106296	80	79638007
Respiratory distress	14.05	11.57	36	106265	58303	79579784
Porphyria non-acute	14.04	11.57	10	106291	739	79637348
Transaminases increased	14.01	11.57	30	106271	51713	79586374
Optic atrophy	14	11.57	15	106286	1918	79636169
Transient ischaemic attack	13.99	11.57	119	106182	52576	79585511
Superficial vein prominence	13.94	11.57	5	106296	82	79638005
Intracranial hypotension	13.91	11.57	8	106293	408	79637679
Myopathy	13.91	11.57	5	106296	20558	79617529
Premature labour	13.89	11.57	33	106268	8357	79629730
Ovarian cyst ruptured	13.88	11.57	11	106290	955	79637132
Neoplasm malignant	13.84	11.57	81	106220	31729	79606358
Circulatory collapse	13.75	11.57	18	106283	37650	79600437
Nephropathy toxic	13.75	11.57	5	106296	20414	79617673
Neutralising antibodies	13.74	11.57	4	106297	32	79638055
Cystocele	13.72	11.57	10	106291	766	79637321
Eosinophil count increased	13.72	11.57	3	106298	17102	79620985
Confusional state	13.69	11.57	321	105980	317676	79320411
COVID-19 pneumonia	13.69	11.57	11	106290	28838	79609249
Abdominal operation	13.63	11.57	9	106292	588	79637499
Suture rupture	13.55	11.57	9	106292	594	79637493
Uterine haemorrhage	13.54	11.57	18	106283	2885	79635202
Paraganglion neoplasm	13.53	11.57	4	106297	34	79638053
Liposarcoma	13.44	11.57	7	106294	293	79637794
Hyperbilirubinaemia	13.43	11.57	8	106293	24510	79613577
Postoperative thrombosis	13.34	11.57	6	106295	181	79637906
Oophorectomy bilateral	13.32	11.57	4	106297	36	79638051
Benign renal neoplasm	13.32	11.57	4	106297	36	79638051
Ovarian neoplasm	13.30	11.57	9	106292	612	79637475
Sinusitis	13.30	11.57	182	106119	195319	79442768
Non-Hodgkin's lymphoma	13.29	11.57	13	106288	1494	79636593
Limb traumatic amputation	13.23	11.57	4	106297	37	79638050
Hyperaesthesia	13.13	11.57	41	106260	12181	79625906
Arterial therapeutic procedure	13.13	11.57	4	106297	38	79638049
Fasciitis	13.11	11.57	10	106291	821	79637266
Transfusion	13.10	11.57	6	106295	21324	79616763
Spinal laminectomy	13.08	11.57	9	106292	629	79637458
Injury	13.02	11.57	56	106245	77440	79560647
Cerebral thrombosis	13.02	11.57	16	106285	2371	79635716
Face oedema	13.02	11.57	11	106290	28125	79609962
Uterine cyst	13.01	11.57	7	106294	313	79637774
Lyme disease	12.98	11.57	19	106282	3331	79634756
Impaired self-care	12.96	11.57	17	106284	2690	79635397
Lung cancer metastatic	12.94	11.57	20	106281	3679	79634408
Erectile dysfunction	12.92	11.57	46	106255	14618	79623469
Arnold-Chiari malformation	12.86	11.57	6	106295	197	79637890
Gastric banding	12.86	11.57	4	106297	41	79638046
Hemianaesthesia	12.85	11.57	8	106293	472	79637615
Liver injury	12.83	11.57	36	106265	56578	79581509
Bipolar I disorder	12.81	11.57	15	106286	2114	79635973
Sinus bradycardia	12.79	11.57	9	106292	25238	79612849
Clinically isolated syndrome	12.77	11.57	4	106297	42	79638045
Urinary tract disorder	12.76	11.57	20	106281	3722	79634365
Faeces discoloured	12.74	11.57	12	106289	29115	79608972
Intestinal cyst	12.73	11.57	6	106295	202	79637885
Escherichia urinary tract infection	12.72	11.57	44	106257	13781	79624306
Aggression	12.62	11.57	31	106270	50927	79587160
Deafness unilateral	12.59	11.57	21	106280	4117	79633970
Colon cancer stage I	12.49	11.57	5	106296	112	79637975
Thyroid function test abnormal	12.47	11.57	18	106283	3116	79634971
Breath sounds abnormal	12.43	11.57	3	106298	15981	79622106
Aspergillus infection	12.39	11.57	5	106296	19156	79618931
Central nervous system infection	12.37	11.57	12	106289	1365	79636722
Muscle disorder	12.35	11.57	25	106276	5682	79632405
Cystitis interstitial	12.32	11.57	12	106289	1371	79636716
Eye pruritus	12.31	11.57	6	106295	20564	79617523
Simple partial seizures	12.29	11.57	9	106292	695	79637392
Chronic leukaemia	12.26	11.57	3	106298	11	79638076
Complication associated with device	12.23	11.57	51	106250	17445	79620642
Myelitis transverse	12.19	11.57	14	106287	1933	79636154
Aneurysm	12.15	11.57	19	106282	3529	79634558
Haemodynamic instability	12.15	11.57	4	106297	17378	79620709
Cardiac failure acute	12.14	11.57	5	106296	18924	79619163
Drug delivery system malfunction	12.14	11.57	9	106292	708	79637379
Cold type haemolytic anaemia	12.12	11.57	7	106294	360	79637727
Arthritis infective	12.08	11.57	31	106270	8240	79629847
Neurilemmoma benign	12.05	11.57	3	106298	12	79638075
Pallor	11.97	11.57	31	106270	50031	79588056
Allergy to metals	11.92	11.57	8	106293	537	79637550
Complication of pregnancy	11.87	11.57	7	106294	374	79637713
Anti-interferon antibody positive	11.86	11.57	3	106298	13	79638074
Malignant melanoma stage II	11.86	11.57	3	106298	13	79638074
Appendix disorder	11.83	11.57	13	106288	1711	79636376
Retinal detachment	11.83	11.57	33	106268	9214	79628873
Shock haemorrhagic	11.78	11.57	6	106295	20054	79618033
Hepatic encephalopathy	11.74	11.57	9	106292	24157	79613930
Benign neoplasm of bladder	11.73	11.57	4	106297	56	79638031
Placenta praevia	11.72	11.57	9	106292	746	79637341
Tubular breast carcinoma	11.68	11.57	3	106298	14	79638073
Otolithiasis	11.68	11.57	3	106298	14	79638073
Rubber sensitivity	11.67	11.57	13	106288	1736	79636351
Pyelonephritis	11.67	11.57	56	106245	20332	79617755
Lobular breast carcinoma in situ	11.66	11.57	4	106297	57	79638030
Malignant mesenteric neoplasm	11.66	11.57	4	106297	57	79638030
Bacteraemia	11.66	11.57	16	106285	32808	79605279
Sensory loss	11.66	11.57	41	106260	12950	79625137
Breast cellulitis	11.65	11.57	7	106294	387	79637700
Glomerular filtration rate decreased	11.62	11.57	8	106293	22694	79615393
Death of relative	11.59	11.57	6	106295	248	79637839
Thrombotic thrombocytopenic purpura	11.57	11.57	26	106275	6350	79631737

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	L03AB07	ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS IMMUNOSTIMULANTS IMMUNOSTIMULANTS Interferons
FDA CS	M0025715	Interferon-beta
MeSH PA	D000276	Adjuvants, Immunologic
MeSH PA	D000890	Anti-Infective Agents
MeSH PA	D000970	Antineoplastic Agents
MeSH PA	D000998	Antiviral Agents
MeSH PA	D007155	Immunologic Factors
FDA EPC	N0000191625	Interferon beta

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Relapsing remitting multiple sclerosis	indication	426373005	DOID:2378

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Interferon alpha/beta receptor	Membrane receptor	P17181 P48551	INAR1_HUMAN INAR2_HUMAN	AGONIST				DRUG LABEL	DRUG LABEL

External reference:

ID	Source
XRO4566Q4R	UNII
4024025	VANDF
C0254119	UMLSCUI
CHEMBL1201562	ChEMBL_ID
D04554	KEGG_DRUG
DB00060	DRUGBANK_ID
CHEMBL2108510	ChEMBL_ID
D000068556	MESH_DESCRIPTOR_UI
153326	RXNORM
4895	MMSL
6144	MMSL
d04011	MMSL
005910	NDDF
108749003	SNOMEDCT_US
386902004	SNOMEDCT_US

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
REBIF	HUMAN PRESCRIPTION DRUG LABEL	1	44087-0022	INJECTION, SOLUTION	22 ug	SUBCUTANEOUS	BLA	30 sections
REBIF	HUMAN PRESCRIPTION DRUG LABEL	1	44087-0022	INJECTION, SOLUTION	22 ug	SUBCUTANEOUS	BLA	30 sections
REBIF	HUMAN PRESCRIPTION DRUG LABEL	1	44087-0044	INJECTION, SOLUTION	44 ug	SUBCUTANEOUS	BLA	30 sections
REBIF	HUMAN PRESCRIPTION DRUG LABEL	1	44087-0044	INJECTION, SOLUTION	44 ug	SUBCUTANEOUS	BLA	30 sections
REBIF REBIDOSE	HUMAN PRESCRIPTION DRUG LABEL	1	44087-3322	INJECTION, SOLUTION	22 ug	SUBCUTANEOUS	BLA	30 sections
REBIF REBIDOSE	HUMAN PRESCRIPTION DRUG LABEL	1	44087-3322	INJECTION, SOLUTION	22 ug	SUBCUTANEOUS	BLA	30 sections
REBIF REBIDOSE	HUMAN PRESCRIPTION DRUG LABEL	1	44087-3344	INJECTION, SOLUTION	44 ug	SUBCUTANEOUS	BLA	30 sections
REBIF REBIDOSE	HUMAN PRESCRIPTION DRUG LABEL	1	44087-3344	INJECTION, SOLUTION	44 ug	SUBCUTANEOUS	BLA	30 sections
Avonex	HUMAN PRESCRIPTION DRUG LABEL	1	59627-002	INJECTION, SOLUTION	30 ug	INTRAMUSCULAR	BLA	28 sections
Avonex	HUMAN PRESCRIPTION DRUG LABEL	1	59627-002	INJECTION, SOLUTION	30 ug	INTRAMUSCULAR	BLA	28 sections
Avonex	HUMAN PRESCRIPTION DRUG LABEL	1	59627-002	INJECTION, SOLUTION	30 ug	INTRAMUSCULAR	BLA	28 sections
Avonex Pen	HUMAN PRESCRIPTION DRUG LABEL	1	59627-003	INJECTION, SOLUTION	30 ug	INTRAMUSCULAR	BLA	28 sections
Avonex Pen	HUMAN PRESCRIPTION DRUG LABEL	1	59627-003	INJECTION, SOLUTION	30 ug	INTRAMUSCULAR	BLA	28 sections
Avonex Pen	HUMAN PRESCRIPTION DRUG LABEL	1	59627-003	INJECTION, SOLUTION	30 ug	INTRAMUSCULAR	BLA	28 sections