interferon beta-1a 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
5139 145258-61-3

Description:

MoleculeDescription

Synonyms:

  • interferon beta-1a
  • avonex
An interferon beta-1 subtype that has a methionine at position 1, a cysteine at position 17, and is glycosylated at position 80. It functions as an ANTI-VIRAL AGENT and IMMUNOMODULATOR and is used to manage the symptoms of RELAPSING-REMITTING MULTIPLE SCLEROSIS. A possible role for IFNs in prophylaxis or early treatment of COVID-19 has been suggested to compensate for possibly insufficient endogenous IFN production. However, the efficacy and safety of IFNs for treatment or prevention of COVID-19 were not established.
  • Molecular weight:
  • Formula:
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA:
  • ALOGS:
  • ROTB: None

Drug dosage:

DoseUnitRoute
4.30 mcg P

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

None

Approvals:

DateAgencyCompanyOrphan
May 17, 1996 FDA BIOGEN
March 13, 1997 EMA Biogen Netherlands B.V.

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Multiple sclerosis relapse 10171.47 11.82 3489 121213 48816 90454929
Influenza like illness 5275.23 11.82 2453 122249 78158 90425587
Fall 1166.43 11.82 2245 122457 479565 90024180
Injection site erythema 1032.21 11.82 947 123755 97555 90406190
Off label use 958.12 11.82 181 124521 1102071 89401674
Breast cancer 915.09 11.82 685 124017 53076 90450669
Optic neuritis 897.25 11.82 377 124325 9301 90494444
Central nervous system lesion 861.90 11.82 387 124315 11259 90492486
Injection site pain 778.65 11.82 1072 123630 172627 90331118
Gait disturbance 755.11 11.82 1314 123388 259182 90244563
Balance disorder 658.47 11.82 738 123964 96342 90407403
Urinary tract infection 653.26 11.82 1354 123348 304278 90199467
Seizure 624.56 11.82 902 123800 151727 90352018
Depression 570.17 11.82 1269 123433 299332 90204413
General symptom 524.79 11.82 298 124404 14370 90489375
Injection site bruising 465.85 11.82 460 124242 51847 90451898
Synovitis 431.62 11.82 4 124698 329748 90173997
Loss of control of legs 410.87 11.82 129 124573 1321 90502424
Contraindicated product administered 389.65 11.82 11 124691 320128 90183617
Magnetic resonance imaging abnormal 388.59 11.82 155 124547 3331 90500414
Infusion related reaction 388.28 11.82 56 124646 416724 90087021
Product use issue 385.20 11.82 16 124686 329903 90173842
Product use in unapproved indication 380.61 11.82 20 124682 336216 90167529
Glossodynia 377.72 11.82 15 124687 321764 90181981
Memory impairment 377.21 11.82 836 123866 196408 90307337
Injection site haematoma 358.68 11.82 180 124522 6742 90497003
Intervertebral disc protrusion 355.93 11.82 297 124405 26899 90476846
Rash 348.32 11.82 350 124352 795750 89707995
Secondary progressive multiple sclerosis 347.63 11.82 116 124586 1463 90502282
Joint swelling 343.00 11.82 132 124570 503168 90000577
Stress 335.48 11.82 483 124219 80912 90422833
Diarrhoea 307.79 11.82 513 124189 938677 89565068
Chills 304.18 11.82 604 124098 131377 90372368
Hypoaesthesia 304.05 11.82 1037 123665 313173 90190572
Abortion spontaneous 303.16 11.82 373 124329 53683 90450062
Cognitive disorder 300.96 11.82 422 124280 68985 90434760
Pericarditis 290.87 11.82 21 124681 270130 90233615
Injection site haemorrhage 282.19 11.82 265 124437 28053 90475692
Myocardial infarction 279.94 11.82 514 124188 105458 90398287
Uterine leiomyoma 275.52 11.82 177 124525 10687 90493058
Stomatitis 272.45 11.82 30 124672 274668 90229077
Abdominal discomfort 269.01 11.82 162 124540 477166 90026579
Helicobacter infection 268.10 11.82 10 124692 226840 90276905
Systemic lupus erythematosus 265.15 11.82 84 124618 361812 90141933
Toxicity to various agents 264.87 11.82 40 124662 287806 90215939
Rheumatoid arthritis 262.43 11.82 86 124616 362528 90141217
Psoriatic arthropathy 260.14 11.82 13 124689 228322 90275423
Muscular weakness 259.68 11.82 747 123955 205919 90297826
Decubitus ulcer 257.23 11.82 175 124527 11638 90492107
Ankle fracture 255.30 11.82 217 124485 20153 90483592
Needle fatigue 253.71 11.82 56 124646 106 90503639
Folliculitis 252.40 11.82 6 124696 204347 90299398
Injection site reaction 248.73 11.82 451 124251 91629 90412116
Peripheral swelling 247.40 11.82 130 124572 412976 90090769
Breast cancer female 240.54 11.82 184 124518 14702 90489043
Cerebrovascular accident 237.54 11.82 525 124177 123008 90380737
Injection site scar 232.33 11.82 81 124621 1176 90502569
Hysterectomy 232.00 11.82 163 124539 11421 90492324
Urinary incontinence 228.24 11.82 270 124432 37296 90466449
Trigeminal neuralgia 224.60 11.82 111 124591 4020 90499725
Musculoskeletal disorder 223.23 11.82 207 124495 21562 90482183
Injection site necrosis 221.97 11.82 82 124620 1419 90502326
Lower respiratory tract infection 219.10 11.82 40 124662 250619 90253126
Muscle injury 215.09 11.82 6 124696 176648 90327097
Wheezing 214.66 11.82 35 124667 238045 90265700
Coronary artery occlusion 213.55 11.82 138 124564 8416 90495329
Intentional product use issue 211.75 11.82 25 124677 216867 90286878
Dyspnoea 208.48 11.82 577 124125 880378 89623367
Peroneal nerve palsy 203.48 11.82 116 124586 5632 90498113
Diabetes mellitus 198.88 11.82 336 124366 64539 90439206
C-reactive protein increased 198.40 11.82 13 124689 181376 90322369
Drug hypersensitivity 192.00 11.82 213 124489 463396 90040349
Wound 190.89 11.82 89 124613 302891 90200854
Blister 190.63 11.82 57 124645 254941 90248804
Drug ineffective 190.37 11.82 1124 123578 1383174 89120571
Injection site infection 186.98 11.82 82 124620 2250 90501495
Caesarean section 183.46 11.82 173 124529 18404 90485341
Injection site abscess 180.87 11.82 70 124632 1384 90502361
Swelling 179.65 11.82 187 124515 418871 90084874
Therapeutic product effect decreased 178.81 11.82 79 124623 277492 90226253
Tremor 177.37 11.82 538 124164 152635 90351110
Muscle spasticity 176.25 11.82 230 124472 35092 90468653
Injection site mass 174.22 11.82 182 124520 21908 90481837
Bladder disorder 173.71 11.82 133 124569 10639 90493106
Therapeutic product effect incomplete 173.67 11.82 29 124673 193867 90309878
Drug interaction 171.39 11.82 83 124619 276370 90227375
Febrile neutropenia 171.27 11.82 12 124690 158337 90345408
Alopecia 170.53 11.82 261 124441 494810 90008935
Head injury 166.49 11.82 210 124492 30978 90472767
Injection site induration 166.08 11.82 128 124574 10340 90493405
Pruritus 161.40 11.82 313 124389 541212 89962533
Neutropenia 159.71 11.82 55 124647 224849 90278896
Oedema 158.62 11.82 40 124662 200255 90303490
Abortion 157.62 11.82 77 124625 2718 90501027
Injection site cellulitis 157.01 11.82 64 124638 1457 90502288
Multiple sclerosis 155.88 11.82 192 124510 27648 90476097
Post procedural complication 152.16 11.82 158 124544 18884 90484861
Injury 147.68 11.82 44 124658 197305 90306440
Arthralgia 145.17 11.82 566 124136 777956 89725789
Thyroid cancer 143.77 11.82 96 124606 6188 90497557
Abdominal pain 143.67 11.82 201 124501 395520 90108225
Progressive multiple sclerosis 142.36 11.82 57 124645 1237 90502508
Irritable bowel syndrome 141.74 11.82 54 124648 207394 90296351
Neuromyelitis optica spectrum disorder 141.28 11.82 59 124643 1431 90502314
Hip fracture 138.72 11.82 198 124504 32879 90470866
Nephrolithiasis 138.36 11.82 245 124457 48840 90454905
Arthropathy 135.98 11.82 183 124519 366059 90137686
Injection site atrophy 135.54 11.82 49 124653 795 90502950
Neurogenic bladder 134.98 11.82 76 124626 3602 90500143
Coordination abnormal 133.87 11.82 156 124546 21200 90482545
Malignant melanoma 131.67 11.82 121 124581 12455 90491290
General physical health deterioration 131.27 11.82 178 124524 354937 90148808
Joint range of motion decreased 129.03 11.82 17 124685 135626 90368119
Malignant neoplasm progression 125.22 11.82 5 124697 106865 90396880
Lip dry 124.48 11.82 3 124699 100952 90402793
Breast cancer in situ 122.94 11.82 56 124646 1684 90502061
Feeling abnormal 120.77 11.82 503 124199 166732 90337013
Discomfort 120.22 11.82 120 124582 274215 90229530
Hemiparesis 118.33 11.82 180 124522 31639 90472106
Cystitis 117.55 11.82 274 124428 66444 90437301
Decreased appetite 116.15 11.82 213 124489 376327 90127418
Acute kidney injury 115.98 11.82 163 124539 320224 90183521
Nausea 114.75 11.82 978 123724 1109338 89394407
Liver injury 112.25 11.82 47 124655 170520 90333225
Thrombosis 112.17 11.82 285 124417 72966 90430779
Completed suicide 110.98 11.82 31 124671 145027 90358718
Inflammation 110.06 11.82 54 124648 178538 90325207
Upper limb fracture 109.97 11.82 142 124560 21436 90482309
Sensory disturbance 109.22 11.82 120 124582 15293 90488452
Cholelithiasis 108.69 11.82 230 124472 52276 90451469
Staphylococcal infection 108.27 11.82 219 124483 48220 90455525
Facet joint syndrome 107.71 11.82 7 124695 98382 90405363
Intracranial aneurysm 105.00 11.82 69 124633 4329 90499416
Injection site discolouration 104.11 11.82 93 124609 9227 90494518
Phobia 103.63 11.82 33 124669 355 90503390
Ovarian cancer 101.40 11.82 80 124622 6687 90497058
Relapsing-remitting multiple sclerosis 101.29 11.82 39 124663 760 90502985
Blindness unilateral 100.19 11.82 84 124618 7652 90496093
Drug delivery device placement 99.07 11.82 25 124677 103 90503642
Dry mouth 98.65 11.82 66 124636 183993 90319752
Asthenia 97.23 11.82 1142 123560 532609 89971136
Speech disorder 97.05 11.82 202 124500 45383 90458362
Psoriasis 96.76 11.82 41 124661 147713 90356032
Suicidal ideation 96.55 11.82 271 124431 73584 90430161
Fibromyalgia 96.50 11.82 85 124617 206184 90297561
Cough 94.30 11.82 232 124470 368730 90135015
Kidney infection 94.10 11.82 145 124557 25771 90477974
Bursitis 93.77 11.82 32 124670 131622 90372123
Dyspepsia 93.49 11.82 81 124621 198079 90305666
Gait inability 89.41 11.82 419 124283 146037 90357708
Dysstasia 89.33 11.82 139 124563 24913 90478832
Impaired healing 88.93 11.82 115 124587 234084 90269661
Therapeutic response decreased 88.38 11.82 10 124692 89719 90414026
Hypercholesterolaemia 88.32 11.82 16 124686 100876 90402869
Muscle spasms 88.06 11.82 621 124081 251262 90252483
Invasive ductal breast carcinoma 87.30 11.82 78 124624 7740 90496005
Influenza 86.91 11.82 401 124301 138863 90364882
Generalised tonic-clonic seizure 86.73 11.82 165 124537 34738 90469007
Prescribed overdose 86.50 11.82 15 124687 97610 90406135
Sleep disorder 86.30 11.82 87 124615 197943 90305802
Procedural anxiety 84.89 11.82 35 124667 821 90502924
Lung neoplasm malignant 84.22 11.82 133 124569 24140 90479605
Dysgraphia 83.62 11.82 56 124646 3627 90500118
Mental impairment 83.59 11.82 109 124593 16611 90487134
Pancytopenia 82.63 11.82 31 124671 120232 90383513
Adverse drug reaction 81.10 11.82 347 124355 116354 90387391
Injection site nodule 80.53 11.82 59 124643 4414 90499331
Liver function test abnormal 80.10 11.82 200 124502 50645 90453100
Lung disorder 78.63 11.82 55 124647 149828 90353917
Gastrointestinal disorder 78.39 11.82 146 124556 256541 90247204
Appendicitis 78.36 11.82 83 124619 10148 90493597
Drug specific antibody present 77.95 11.82 63 124639 5451 90498294
Therapy non-responder 77.40 11.82 46 124656 136658 90367087
Loss of personal independence in daily activities 76.78 11.82 46 124656 136059 90367686
Hypotension 76.72 11.82 213 124489 325184 90178561
Intervertebral disc disorder 76.38 11.82 62 124640 5398 90498347
Hyperkalaemia 76.24 11.82 3 124699 64961 90438784
Type 2 diabetes mellitus 75.92 11.82 101 124601 203143 90300602
Vomiting 75.65 11.82 707 123995 787586 89716159
Blindness 75.36 11.82 133 124569 26435 90477310
Visual impairment 75.23 11.82 371 124331 131994 90371751
Neutralising antibodies positive 75.22 11.82 25 124677 311 90503434
Pulmonary fibrosis 75.06 11.82 27 124675 107476 90396269
Scar 74.86 11.82 99 124603 15296 90488449
Meningioma benign 74.29 11.82 25 124677 324 90503421
Grip strength decreased 74.21 11.82 18 124684 92558 90411187
Electrocardiogram QT prolonged 74.14 11.82 7 124695 72449 90431296
Hyponatraemia 74.12 11.82 46 124656 133492 90370253
Temperature intolerance 73.94 11.82 87 124615 11943 90491802
Product quality issue 72.94 11.82 11 124691 79314 90424431
Diplopia 72.90 11.82 137 124565 28577 90475168
Aphasia 72.34 11.82 173 124529 42639 90461106
Injection site ulcer 72.23 11.82 29 124673 634 90503111
Sinusitis 71.99 11.82 237 124465 342851 90160894
Cholecystectomy 70.57 11.82 84 124618 11671 90492074
Red blood cell sedimentation rate increased 70.37 11.82 14 124688 82581 90421164
Spinal stenosis 69.69 11.82 102 124600 17322 90486423
Weight increased 67.75 11.82 320 124382 417607 90086138
Ovarian cyst 67.28 11.82 100 124602 17218 90486527
Cervix carcinoma 66.55 11.82 47 124655 3319 90500426
Hypokalaemia 66.32 11.82 50 124652 131066 90372679
Neoplasm malignant 66.20 11.82 145 124557 33735 90470010
Gastric bypass 66.19 11.82 39 124663 2015 90501730
COVID-19 66.07 11.82 81 124621 168762 90334983
Peripheral venous disease 65.94 11.82 17 124685 83904 90419841
Abdominal pain upper 65.60 11.82 236 124466 332438 90171307
Intraductal proliferative breast lesion 65.47 11.82 47 124655 3406 90500339
Adjustment disorder with depressed mood 65.34 11.82 3 124699 56750 90446995
Endometriosis 65.18 11.82 60 124642 6188 90497557
Blood creatinine increased 65 11.82 29 124673 101357 90402388
Concussion 64.53 11.82 78 124624 11013 90492732
Thrombocytopenia 64.35 11.82 118 124584 208607 90295138
Ligament rupture 64.24 11.82 48 124654 3700 90500045
Anxiety 64.12 11.82 680 124022 309092 90194653
Drug abuse 64.10 11.82 17 124685 82330 90421415
Ill-defined disorder 63.98 11.82 97 124605 184794 90318951
Autoimmune hepatitis 63.85 11.82 75 124627 10276 90493469
Cellulitis 63.77 11.82 272 124430 91065 90412680
Burning sensation 63.45 11.82 212 124490 63240 90440505
Hospitalisation 63.33 11.82 50 124652 128050 90375695
Vision blurred 63.29 11.82 310 124392 109983 90393762
Injury associated with device 63.10 11.82 51 124651 4413 90499332
Basedow's disease 62.92 11.82 21 124681 265 90503480
Condition aggravated 62.86 11.82 521 124181 595024 89908721
Delirium 62.12 11.82 33 124669 104326 90399419
Cervical spinal stenosis 62.08 11.82 41 124661 2594 90501151
Wound infection 61.37 11.82 35 124667 106367 90397378
Medication error 61.28 11.82 20 124682 84632 90419113
Lumbar spinal stenosis 60.84 11.82 55 124647 5542 90498203
Retinal exudates 60.80 11.82 26 124676 670 90503075
Intervertebral disc degeneration 60.41 11.82 95 124607 17179 90486566
Bone erosion 60.40 11.82 3 124699 53018 90450727
Frequent bowel movements 59.60 11.82 5 124697 56930 90446815
Appendicitis perforated 59.50 11.82 37 124665 2109 90501636
Clostridial infection 59.34 11.82 50 124652 4586 90499159
Colon cancer 58.89 11.82 74 124628 10870 90492875
Primary progressive multiple sclerosis 58.44 11.82 16 124686 96 90503649
Mucosal inflammation 57.82 11.82 6 124696 57619 90446126
Agraphia 57.78 11.82 13 124689 28 90503717
Paralysis 57.65 11.82 75 124627 11403 90492342
Meningioma 57.43 11.82 51 124651 5020 90498725
Paraesthesia 56.31 11.82 559 124143 249767 90253978
Depressed mood 55.83 11.82 174 124528 50048 90453697
Urticaria 55.77 11.82 231 124471 312503 90191242
Postoperative wound infection 55.74 11.82 80 124622 13346 90490399
Pulmonary thrombosis 55.62 11.82 68 124634 9714 90494031
Focal dyscognitive seizures 55.54 11.82 41 124661 3103 90500642
Bipolar disorder 55.25 11.82 65 124637 8920 90494825
Nail disorder 54.75 11.82 8 124694 59059 90444686
Ataxia 54.67 11.82 93 124609 17949 90485796
Vertigo 54.34 11.82 215 124487 69596 90434149
Thyroid disorder 54.32 11.82 92 124610 17693 90486052
Interstitial lung disease 53.66 11.82 19 124683 76386 90427359
Gallbladder disorder 53.43 11.82 97 124605 19706 90484039
Tachycardia 53.32 11.82 84 124618 157589 90346156
Oxygen saturation decreased 53.07 11.82 42 124660 107441 90396304
Uterine cancer 52.88 11.82 50 124652 5335 90498410
Night sweats 52.27 11.82 60 124642 128706 90375039
Feeling cold 51.91 11.82 116 124586 27349 90476396
Frustration tolerance decreased 51.70 11.82 59 124643 7837 90495908
Lactic acidosis 51.30 11.82 5 124697 50458 90453287
Micturition urgency 51.20 11.82 70 124632 11163 90492582
Metabolic acidosis 50.55 11.82 8 124694 55668 90448077
X-ray abnormal 50.41 11.82 3 124699 45421 90458324
Surgery 50.34 11.82 156 124546 44731 90459014
Myelosuppression 50.28 11.82 7 124695 53584 90450161
Adverse reaction 50.12 11.82 120 124582 29592 90474153
Loss of consciousness 49.69 11.82 347 124355 139891 90363854
Asthma 49.59 11.82 169 124533 241991 90261754
Drug ineffective for unapproved indication 49.57 11.82 15 124687 66629 90437116
Intentional product misuse 49.53 11.82 31 124671 89573 90414172
Sleep disorder due to a general medical condition 49.51 11.82 3 124699 44735 90459010
Fear 49.47 11.82 85 124617 16537 90487208
Blood potassium decreased 49.08 11.82 161 124541 47566 90456179
Treatment failure 49.05 11.82 233 124469 303695 90200050
Dyspnoea exertional 49.04 11.82 19 124683 72269 90431476
Paraparesis 48.97 11.82 37 124665 2901 90500844
Illness 48.67 11.82 26 124676 81943 90421802
Injection site calcification 48.48 11.82 11 124691 25 90503720
Intentional overdose 48.46 11.82 35 124667 93799 90409946
Lack of injection site rotation 47.61 11.82 24 124678 907 90502838
Coronary artery disease 47.54 11.82 127 124575 33496 90470249
Liver function test increased 47.40 11.82 29 124673 84826 90418919
Procedural complication 47.37 11.82 49 124653 5829 90497916
Muscle atrophy 47.12 11.82 58 124644 8343 90495402
Thyroid neoplasm 46.66 11.82 41 124661 3980 90499765
Malaise 46.46 11.82 1094 123608 584892 89918853
Meniscus injury 46.41 11.82 57 124645 8180 90495565
Ruptured cerebral aneurysm 45.97 11.82 20 124682 538 90503207
Tibia fracture 45.94 11.82 49 124653 6038 90497707
Breast cancer stage III 45.60 11.82 30 124672 84417 90419328
Blood pressure systolic increased 45.49 11.82 12 124690 58333 90445412
Injection site scab 45.39 11.82 21 124681 655 90503090
Maternal exposure timing unspecified 44.80 11.82 97 124605 22386 90481359
Musculoskeletal stiffness 44.60 11.82 233 124469 296299 90207446
Nerve compression 43.93 11.82 63 124639 10503 90493242
Breast cancer stage I 43.91 11.82 60 124642 9564 90494181
Ectopic pregnancy 43.65 11.82 36 124666 3205 90500540
Papillary thyroid cancer 43.60 11.82 33 124669 2594 90501151
Neutrophil count decreased 43.49 11.82 22 124680 71510 90432235
Hypersensitivity 43.40 11.82 408 124294 454269 90049476
Autoimmune disorder 43.18 11.82 26 124676 76718 90427027
Onychomadesis 43.17 11.82 6 124696 45992 90457753
Musculoskeletal pain 42.67 11.82 109 124593 171142 90332603
Pleural effusion 42.47 11.82 55 124647 111936 90391809
Band sensation 42.40 11.82 24 124678 1149 90502596
Benign breast neoplasm 42.37 11.82 25 124677 1295 90502450
Blepharospasm 42.11 11.82 12 124690 55433 90448312
Paraplegia 42.03 11.82 36 124666 3376 90500369
Blood cholesterol increased 42.02 11.82 146 124556 207866 90295879
Anal incontinence 41.90 11.82 78 124624 16152 90487593
Hepatitis C 41.73 11.82 45 124657 5615 90498130
Rotator cuff syndrome 41.72 11.82 77 124625 15842 90487903
Crying 41.57 11.82 102 124600 25543 90478202
Fatigue 41.32 11.82 1961 122741 1152062 89351683
Retinitis 41.32 11.82 3 124699 38455 90465290
Hypocalcaemia 41.03 11.82 5 124697 42363 90461382
Accidental exposure to product 41.03 11.82 5 124697 42361 90461384
Bladder cancer 40.81 11.82 45 124657 5756 90497989
Panic attack 40.78 11.82 103 124599 26262 90477483
Breech presentation 40.68 11.82 24 124678 1243 90502502
Sciatica 40.32 11.82 48 124654 101334 90402411
Brain neoplasm 40.01 11.82 41 124661 4823 90498922
Infection 39.87 11.82 313 124389 361781 90141964
Haemorrhage in pregnancy 39.74 11.82 29 124673 2156 90501589
Neuralgia 39.61 11.82 114 124588 31386 90472359
Nasal congestion 39.44 11.82 34 124668 83380 90420365
Reaction to preservatives 38.85 11.82 14 124688 225 90503520
Mental disorder 38.76 11.82 115 124587 32203 90471542
Autoimmune thyroiditis 38.53 11.82 44 124658 5849 90497896
Appendicectomy 38.42 11.82 35 124667 3561 90500184
Neutralising antibodies 38.22 11.82 10 124692 49 90503696
Pain in extremity 38.12 11.82 849 123853 449680 90054065
Bladder dysfunction 37.96 11.82 22 124680 1102 90502643
Dehydration 37.95 11.82 422 124280 194025 90309720
Prolonged labour 37.88 11.82 18 124684 597 90503148
Muscle tightness 37.76 11.82 67 124635 13372 90490373
Central venous catheterisation 37.63 11.82 31 124671 2755 90500990
Raynaud's phenomenon 37.53 11.82 22 124680 1126 90502619
Hypoglycaemia 37.46 11.82 25 124677 69823 90433922
Haemolytic uraemic syndrome 37.39 11.82 31 124671 2780 90500965
Sedation 37.38 11.82 10 124692 48161 90455584
Multiple organ dysfunction syndrome 37.28 11.82 24 124678 68312 90435433
Headache 37.25 11.82 1495 123207 861251 89642494
Foot fracture 37.11 11.82 100 124602 26506 90477239
Brain neoplasm benign 36.98 11.82 14 124688 260 90503485
Drug reaction with eosinophilia and systemic symptoms 36.94 11.82 7 124695 42751 90460994
Productive cough 36.94 11.82 31 124671 77032 90426713
Heavy menstrual bleeding 36.90 11.82 85 124617 20445 90483300
Myelitis transverse 36.66 11.82 24 124678 1496 90502249
Overdose 36.56 11.82 104 124598 157605 90346140
Injection site fibrosis 36.29 11.82 8 124694 15 90503730
Emotional disorder 36.15 11.82 70 124632 14927 90488818
Amnesia 35.83 11.82 264 124438 108241 90395504
Mouth ulceration 35.72 11.82 6 124696 39968 90463777
Expanded disability status scale score increased 35.72 11.82 19 124683 804 90502941
Optic nerve disorder 35.67 11.82 22 124680 1236 90502509
Cardiac disorder 35.63 11.82 164 124538 56708 90447037
Dysarthria 35.54 11.82 159 124543 54323 90449422
Injection site inflammation 35.06 11.82 37 124665 4504 90499241
Neuropathy peripheral 35.04 11.82 86 124616 136884 90366861
Hernia 35.01 11.82 67 124635 14164 90489581
Injection site injury 34.93 11.82 20 124682 979 90502766
Haematochezia 34.64 11.82 28 124674 70885 90432860
Vitamin D decreased 34.01 11.82 60 124642 11919 90491826
Haemoglobin decreased 33.84 11.82 112 124590 161844 90341901
Ligament sprain 33.80 11.82 67 124635 14532 90489213
Dry skin 33.66 11.82 43 124659 88030 90415715
Sarcoidosis 33.65 11.82 56 124646 10617 90493128
Uterine disorder 33.08 11.82 31 124671 3270 90500475
Anaemia 33.04 11.82 318 124384 352484 90151261
Injection site irritation 32.89 11.82 41 124661 5974 90497771
Fear of injection 32.83 11.82 49 124653 8466 90495279
Pollakiuria 32.74 11.82 110 124592 32895 90470850
Pulmonary sarcoidosis 32.53 11.82 21 124681 1278 90502467
Hypoxia 32.45 11.82 31 124671 72368 90431377
Focal segmental glomerulosclerosis 32.39 11.82 24 124678 1827 90501918
Porphyria non-acute 32.14 11.82 13 124689 290 90503455
Nerve injury 32.02 11.82 56 124646 11050 90492695
Bradycardia 31.98 11.82 41 124661 83806 90419939
Urosepsis 31.85 11.82 82 124620 21150 90482595
Mammoplasty 31.79 11.82 17 124685 727 90503018
Laryngitis 31.78 11.82 15 124687 50738 90453007
Thyroid function test abnormal 31.69 11.82 33 124669 3956 90499789
Incontinence 31.52 11.82 62 124640 13373 90490372
Procedural pain 31.19 11.82 109 124593 33251 90470494
JC polyomavirus test 31.13 11.82 8 124694 36 90503709
Serotonin syndrome 31.09 11.82 7 124695 37880 90465865
Rectal haemorrhage 31 11.82 41 124661 82703 90421042
Wound infection staphylococcal 30.94 11.82 28 124674 2825 90500920
Endometrial cancer 30.72 11.82 31 124671 3581 90500164
Wrist fracture 30.67 11.82 67 124635 15557 90488188
Product administered at inappropriate site 30.60 11.82 33 124669 4118 90499627
Rash pruritic 30.53 11.82 41 124661 82173 90421572
Deafness unilateral 30.50 11.82 30 124672 3361 90500384
Rectocele 30.44 11.82 20 124682 1254 90502491
Basal cell carcinoma 30.27 11.82 108 124594 33281 90470464
Post procedural haemorrhage 30.23 11.82 48 124654 8750 90494995
Demyelination 30.19 11.82 46 124656 8094 90495651
Diplegia 30.10 11.82 21 124681 1454 90502291
Cholecystitis 30.02 11.82 70 124632 16970 90486775
Joint stiffness 29.93 11.82 38 124664 78004 90425741
Live birth 29.84 11.82 39 124663 79068 90424677
Blindness transient 29.84 11.82 34 124668 4509 90499236
Scoliosis 29.79 11.82 48 124654 8859 90494886
Facial bones fracture 29.77 11.82 31 124671 3716 90500029
Retinal tear 29.76 11.82 21 124681 1481 90502264
Migraine 29.66 11.82 396 124306 189996 90313749
Road traffic accident 29.57 11.82 251 124451 107375 90396370
Thermal burn 29.12 11.82 41 124661 6721 90497024
Goitre 29.09 11.82 41 124661 6726 90497019
Suicidal behaviour 29.07 11.82 27 124675 2817 90500928
Rhinorrhoea 28.96 11.82 48 124654 88268 90415477
Impaired self-care 28.95 11.82 22 124680 1740 90502005
Lung adenocarcinoma 28.95 11.82 37 124665 5528 90498217
Chronic leukaemia 28.91 11.82 6 124696 7 90503738
Abdominal distension 28.91 11.82 88 124614 130513 90373232
Incorrect dose administered 28.67 11.82 40 124662 78890 90424855
Motor dysfunction 28.57 11.82 74 124628 19156 90484589
JC polyomavirus test positive 28.51 11.82 22 124680 1780 90501965
Drug resistance 28.51 11.82 4 124698 30445 90473300
Fibula fracture 28.32 11.82 32 124670 4205 90499540
Prescribed underdose 28.28 11.82 37 124665 74982 90428763
Cellulitis staphylococcal 28.04 11.82 17 124685 926 90502819
Calculus bladder 27.95 11.82 15 124687 646 90503099
Lipoatrophy 27.92 11.82 12 124690 313 90503432
Colon cancer stage III 27.90 11.82 10 124692 158 90503587
Visual acuity reduced 27.78 11.82 83 124619 23327 90480418
Spinal disorder 27.53 11.82 54 124648 11625 90492120
Renal cell carcinoma 27.31 11.82 30 124672 3821 90499924
Cartilage injury 27.31 11.82 23 124679 2108 90501637
Febrile convulsion 27.18 11.82 14 124688 554 90503191
Conversion disorder 27.17 11.82 23 124679 2123 90501622
Renal impairment 27.11 11.82 66 124636 105355 90398390
Cardiac failure 27.03 11.82 70 124632 109426 90394319
Feeling of body temperature change 26.96 11.82 36 124666 5613 90498132
Fluid retention 26.96 11.82 50 124652 88041 90415704
Partial seizures 26.89 11.82 41 124661 7219 90496526
Poor venous access 26.84 11.82 73 124629 19454 90484291
Erythema 26.71 11.82 195 124507 229051 90274694
Varicose vein 26.60 11.82 41 124661 7286 90496459
Osteonecrosis 26.51 11.82 88 124614 26153 90477592
Septic shock 26.44 11.82 47 124655 84113 90419632
Decreased immune responsiveness 26.38 11.82 45 124657 8703 90495042
Drug tolerance decreased 26.23 11.82 6 124696 32124 90471621
Pneumonitis 26.23 11.82 14 124688 44156 90459589
Injection site anaesthesia 26.16 11.82 7 124695 38 90503707
Breast cancer recurrent 26.16 11.82 35 124667 5468 90498277
Injection site swelling 26.05 11.82 156 124546 59683 90444062
Hemianaesthesia 26.00 11.82 12 124690 372 90503373
Inappropriate schedule of product administration 25.92 11.82 112 124590 149821 90353924
Limb mass 25.92 11.82 28 124674 3500 90500245
Gallbladder operation 25.83 11.82 25 124677 2746 90500999
Agranulocytosis 25.81 11.82 8 124694 34994 90468751
Intervertebral disc operation 25.79 11.82 16 124686 908 90502837
Hepatic steatosis 25.76 11.82 110 124592 36835 90466910
Thrombotic thrombocytopenic purpura 25.55 11.82 30 124672 4108 90499637
Cholecystitis infective 25.45 11.82 21 124681 1871 90501874
Skin cancer 25.44 11.82 57 124645 13462 90490283
Accident 25.37 11.82 39 124663 6915 90496830
Urinary retention 25.26 11.82 111 124591 37633 90466112
Drug level increased 25.18 11.82 4 124698 27758 90475987
Skin laceration 25.15 11.82 86 124616 25949 90477796
Benign lung neoplasm 25.13 11.82 8 124694 86 90503659
Skin exfoliation 25.09 11.82 34 124668 67879 90435866
Chronic lymphocytic leukaemia 24.78 11.82 26 124676 3144 90500601
Urinary tract disorder 24.76 11.82 28 124674 3683 90500062
Confusional state 24.74 11.82 378 124324 385827 90117918
Death 24.73 11.82 812 123890 455739 90048006
Oral candidiasis 24.58 11.82 9 124693 35446 90468299
Cervical dysplasia 24.50 11.82 29 124673 4005 90499740
Injection site pruritus 24.50 11.82 142 124560 53692 90450053
Homicidal ideation 24.45 11.82 20 124682 1760 90501985
Facial paralysis 24.35 11.82 61 124641 15473 90488272
Precancerous cells present 24.33 11.82 19 124683 1564 90502181
Spondylolisthesis 24.26 11.82 29 124673 4046 90499699
Incoherent 24.19 11.82 32 124670 4945 90498800
Anti-interferon antibody positive 24.12 11.82 6 124696 23 90503722
Constipation 24.06 11.82 258 124444 280137 90223608
Intervertebral disc injury 23.98 11.82 9 124693 163 90503582
International normalised ratio increased 23.97 11.82 18 124684 47298 90456447
Cerebral atrophy 23.96 11.82 34 124668 5612 90498133
Rectal cancer 23.82 11.82 22 124680 2279 90501466
Rash erythematous 23.64 11.82 33 124669 65071 90438674
Rib fracture 23.53 11.82 85 124617 26350 90477395
Fat necrosis 23.50 11.82 14 124688 738 90503007
Dry eye 23.49 11.82 27 124675 57904 90445841
Rubber sensitivity 23.49 11.82 24 124678 2813 90500932
Oedema peripheral 23.49 11.82 234 124468 257681 90246064
Onychomycosis 23.47 11.82 11 124691 37365 90466380
Lumbar radiculopathy 23.45 11.82 23 124679 2568 90501177
Progesterone receptor assay positive 23.37 11.82 11 124691 357 90503388
Ovarian neoplasm 23.28 11.82 15 124687 910 90502835
Fractured coccyx 23.22 11.82 17 124685 1270 90502475
Herpes zoster 23.05 11.82 215 124487 94429 90409316
Vein disorder 23 11.82 33 124669 5503 90498242
Lupus-like syndrome 22.98 11.82 20 124682 48826 90454919
Hand fracture 22.97 11.82 37 124665 6828 90496917
Drug dependence 22.92 11.82 6 124696 29321 90474424
Obstructive airways disorder 22.86 11.82 4 124698 25865 90477880
Large intestine polyp 22.85 11.82 44 124658 9342 90494403
Hypothyroidism 22.81 11.82 138 124564 52989 90450756
Myalgia 22.80 11.82 353 124349 174772 90328973
Gun shot wound 22.77 11.82 8 124694 119 90503626
Abnormal labour 22.72 11.82 7 124695 67 90503678
Knee operation 22.68 11.82 37 124665 6899 90496846
Exposure during pregnancy 22.68 11.82 214 124488 238196 90265549
Malignant melanoma in situ 22.54 11.82 15 124687 961 90502784
Anaesthetic complication 22.53 11.82 22 124680 2443 90501302
Nephrotic syndrome 22.46 11.82 38 124664 7301 90496444
Post procedural infection 22.32 11.82 48 124654 11026 90492719
Hyperaesthesia 22.28 11.82 47 124655 10655 90493090
Lung adenocarcinoma stage I 22.20 11.82 6 124696 34 90503711
Umbilical cord around neck 22.11 11.82 9 124693 204 90503541
Oestrogen receptor assay positive 22.09 11.82 12 124690 530 90503215
Incision site complication 22.07 11.82 13 124689 671 90503074
Cephalo-pelvic disproportion 22.07 11.82 9 124693 205 90503540
Gait spastic 21.97 11.82 10 124692 300 90503445
Breast calcifications 21.86 11.82 17 124685 1391 90502354
Hypoacusis 21.85 11.82 86 124616 27764 90475981
Fibrocystic breast disease 21.82 11.82 16 124686 1198 90502547
Haemorrhagic adrenal infarction 21.77 11.82 6 124696 37 90503708
Adrenal insufficiency 21.77 11.82 7 124695 29914 90473831
Impaired quality of life 21.76 11.82 3 124699 23141 90480604
Injection site rash 21.75 11.82 78 124624 24095 90479650
Aspartate aminotransferase increased 21.74 11.82 227 124475 102710 90401035
Depressed level of consciousness 21.67 11.82 42 124660 72742 90431003
Cytomegalovirus infection 21.65 11.82 5 124697 26597 90477148
Relapsing multiple sclerosis 21.64 11.82 9 124693 216 90503529
Umbilical hernia 21.60 11.82 26 124676 3654 90500091
Angioedema 21.51 11.82 35 124667 64841 90438904
Full blood count decreased 21.51 11.82 7 124695 29682 90474063
Atrophy 21.49 11.82 20 124682 2092 90501653
Rash maculo-papular 21.48 11.82 15 124687 40918 90462827
Colostomy closure 21.47 11.82 8 124694 142 90503603
Blood creatine phosphokinase increased 21.38 11.82 10 124692 34013 90469732
Haemorrhagic ovarian cyst 21.34 11.82 13 124689 714 90503031
Obesity 21.33 11.82 74 124628 105433 90398312
Gamma-glutamyltransferase increased 21.28 11.82 106 124596 37846 90465899
Ovarian cancer stage III 21.06 11.82 10 124692 331 90503414
Lipodystrophy acquired 20.77 11.82 17 124685 1497 90502248
Volvulus 20.77 11.82 20 124682 2183 90501562
Eye pruritus 20.75 11.82 7 124695 29020 90474725
Tumefactive multiple sclerosis 20.44 11.82 7 124695 96 90503649
Aneurysm 20.43 11.82 25 124677 3575 90500170
Therapy partial responder 20.39 11.82 3 124699 22040 90481705
Muscle disorder 20.37 11.82 31 124671 5448 90498297
Chondropathy 20.35 11.82 21 124681 2491 90501254
Intervertebral disc displacement 20.35 11.82 11 124691 481 90503264
Optic atrophy 20.32 11.82 17 124685 1544 90502201
Product prescribing error 20.32 11.82 8 124694 30137 90473608
Crohn's disease 20.28 11.82 29 124673 4822 90498923
Eosinophilia 20.20 11.82 7 124695 28526 90475219
Gastric cyst 20.18 11.82 7 124695 100 90503645
Cerebral thrombosis 20.15 11.82 18 124684 1785 90501960
Spinal osteoarthritis 20.05 11.82 65 124637 19083 90484662
Magnetic resonance imaging head abnormal 20.04 11.82 21 124681 2535 90501210
Hypervolaemia 20.02 11.82 10 124692 32747 90470998
Blood pressure diastolic decreased 20.02 11.82 6 124696 26820 90476925
Disability 20.01 11.82 16 124686 40729 90463016
Viral infection 20.01 11.82 111 124591 41303 90462442
Foot deformity 19.95 11.82 32 124670 59619 90444126
Dermatitis atopic 19.95 11.82 4 124698 23468 90480277
Oral pain 19.94 11.82 10 124692 32673 90471072
Pneumocystis jirovecii pneumonia 19.86 11.82 3 124699 21613 90482132
Limb injury 19.84 11.82 91 124611 31417 90472328
Incisional hernia 19.71 11.82 18 124684 1838 90501907
Enterocele 19.70 11.82 6 124696 55 90503690
Malignant hypertension 19.67 11.82 15 124687 1192 90502553
Chronic obstructive pulmonary disease 19.66 11.82 171 124531 73658 90430087
Benign hydatidiform mole 19.59 11.82 8 124694 183 90503562
Skin haemorrhage 19.57 11.82 3 124699 21377 90482368
Post procedural stroke 19.51 11.82 6 124696 57 90503688
Lung cancer metastatic 19.48 11.82 22 124680 2889 90500856
Throat irritation 19.42 11.82 23 124679 48672 90455073
Skin graft 19.36 11.82 12 124690 680 90503065
Platelet count decreased 19.26 11.82 110 124592 136859 90366886
Bladder prolapse 19.26 11.82 19 124683 2136 90501609
Cardiac perforation 19.15 11.82 6 124696 61 90503684
Vaccination complication 19.13 11.82 14 124688 1045 90502700
Gastrointestinal haemorrhage 19.13 11.82 62 124640 90186 90413559
Pelvic fracture 19.06 11.82 55 124647 15164 90488581
Hepatic enzyme increased 18.92 11.82 366 124336 360370 90143375
No adverse event 18.91 11.82 159 124543 67823 90435922
Cardiomyopathy 18.87 11.82 66 124636 20140 90483605
Oophorectomy 18.82 11.82 12 124690 715 90503030
Schwannoma 18.80 11.82 7 124695 124 90503621
Blood calcium decreased 18.77 11.82 9 124693 30173 90473572
Heat stroke 18.75 11.82 13 124689 891 90502854
Cerebral cyst 18.73 11.82 9 124693 306 90503439
Female genital operation 18.71 11.82 5 124697 27 90503718
Hypercalcaemia 18.71 11.82 12 124690 34228 90469517
Abortion missed 18.70 11.82 18 124684 1964 90501781
Skull fracture 18.64 11.82 15 124687 1290 90502455
Rhabdomyolysis 18.59 11.82 26 124676 51230 90452515
Lyme disease 18.59 11.82 26 124676 4236 90499509
Suture rupture 18.43 11.82 8 124694 214 90503531
Alanine aminotransferase increased 18.36 11.82 246 124456 118092 90385653
Cardio-respiratory arrest 18.31 11.82 37 124665 63103 90440642
Viral pericarditis 18.26 11.82 5 124697 30 90503715
Mobility decreased 18.26 11.82 463 124239 250271 90253474
Cholestasis 18.15 11.82 14 124688 36285 90467460
Foetal heart rate abnormal 18.02 11.82 13 124689 949 90502796
Eczema 18.02 11.82 28 124674 52842 90450903
Myelitis 17.98 11.82 18 124684 2060 90501685
Pre-eclampsia 17.97 11.82 44 124658 11004 90492741
Primary biliary cholangitis 17.96 11.82 15 124687 1359 90502386
Drug delivery system malfunction 17.89 11.82 15 124687 1366 90502379
Transient ischaemic attack 17.80 11.82 111 124591 43065 90460680
Meningitis viral 17.66 11.82 16 124686 1616 90502129
Nervousness 17.61 11.82 93 124609 33963 90469782
Pituitary tumour benign 17.59 11.82 18 124684 2114 90501631
Anger 17.58 11.82 50 124652 13670 90490075
Uterine prolapse 17.53 11.82 15 124687 1405 90502340
Colon cancer metastatic 17.52 11.82 15 124687 1406 90502339
Apparent death 17.46 11.82 14 124688 1198 90502547
Hypertension 17.44 11.82 783 123919 456749 90046996
Brain operation 17.36 11.82 11 124691 648 90503097
Tachypnoea 17.36 11.82 4 124698 21305 90482440
Cervical vertebral fracture 17.29 11.82 22 124680 3271 90500474
Endometrial adenocarcinoma 17.26 11.82 15 124687 1435 90502310
Thyroid cyst 17.25 11.82 11 124691 655 90503090
Clavicle fracture 17.24 11.82 24 124678 3892 90499853
Acute disseminated encephalomyelitis 17.22 11.82 8 124694 252 90503493
Endometrial cancer stage I 17.16 11.82 8 124694 254 90503491
Intervertebral disc compression 17.12 11.82 14 124688 1231 90502514
Pancreatic cyst 17.05 11.82 18 124684 2192 90501553
Incision site abscess 16.98 11.82 9 124693 378 90503367
Vitamin D deficiency 16.96 11.82 58 124644 17498 90486247
Sjogren's syndrome 16.96 11.82 13 124689 1041 90502704
Ocular hyperaemia 16.94 11.82 13 124689 33785 90469960
Benign neoplasm of thyroid gland 16.87 11.82 14 124688 1257 90502488
Dysphagia 16.85 11.82 232 124470 112046 90391699
Urinary control neurostimulator implantation 16.77 11.82 3 124699 0 90503745
Rectal cancer stage I 16.77 11.82 3 124699 0 90503745
Biopsy bladder 16.77 11.82 3 124699 0 90503745
Breast dysplasia 16.77 11.82 3 124699 0 90503745
Neurological complication associated with device 16.77 11.82 3 124699 0 90503745
Face presentation 16.77 11.82 3 124699 0 90503745
Neurilemmoma benign 16.77 11.82 3 124699 0 90503745
Non-small cell lung cancer stage IIIB 16.77 11.82 3 124699 0 90503745
Ophthalmoplegia 16.72 11.82 16 124686 1733 90502012
Pneumonia 16.70 11.82 1054 123648 637005 89866740
Spinal meningeal cyst 16.70 11.82 5 124697 43 90503702
Injection site hypertrophy 16.67 11.82 6 124696 96 90503649
Amniotic fluid volume decreased 16.67 11.82 10 124692 534 90503211
Patella fracture 16.65 11.82 19 124683 2524 90501221
Spider vein 16.64 11.82 9 124693 394 90503351
Tubulointerstitial nephritis 16.63 11.82 7 124695 25336 90478409
Anaphylactic reaction 16.62 11.82 63 124639 87461 90416284
Postoperative thrombosis 16.60 11.82 7 124695 174 90503571
Panic reaction 16.57 11.82 26 124676 4691 90499054
Narcolepsy 16.54 11.82 15 124687 1517 90502228
Appendix disorder 16.54 11.82 15 124687 1517 90502228
Blood triglycerides increased 16.53 11.82 49 124653 13712 90490033
Creatinine renal clearance decreased 16.53 11.82 3 124699 18896 90484849
Carotid artery aneurysm 16.51 11.82 9 124693 400 90503345
Injection related reaction 16.48 11.82 13 124689 1086 90502659
Uterine mass 16.39 11.82 9 124693 406 90503339
Spinal cord disorder 16.27 11.82 15 124687 1550 90502195
Progressive multifocal leukoencephalopathy 16.26 11.82 53 124649 15602 90488143
Exposure via father 16.18 11.82 8 124694 290 90503455
Deep vein thrombosis 16.14 11.82 195 124507 91425 90412320
Somnolence 16.12 11.82 197 124505 208887 90294858
Pustular psoriasis 16.11 11.82 3 124699 18553 90485192
Skin indentation 16.03 11.82 5 124697 50 90503695
Nasopharyngitis 16.00 11.82 432 124270 406672 90097073
Glioblastoma 15.99 11.82 12 124690 931 90502814
Abdominal adhesions 15.97 11.82 22 124680 3533 90500212
Adenomyosis 15.89 11.82 10 124692 582 90503163
Urinary tract infection staphylococcal 15.88 11.82 9 124693 432 90503313
Immune system disorder 15.86 11.82 44 124658 11861 90491884
Lipoma 15.76 11.82 20 124682 2966 90500779
Reproductive tract disorder 15.73 11.82 7 124695 199 90503546
Arthroscopy 15.66 11.82 11 124691 770 90502975
Drug intolerance 15.56 11.82 483 124219 447108 90056637
Ear infection 15.45 11.82 47 124655 69728 90434017
Retinal detachment 15.42 11.82 31 124671 6791 90496954
Gastrointestinal viral infection 15.41 11.82 14 124688 1419 90502326
Opportunistic infection 15.41 11.82 17 124685 2176 90501569
Bone marrow failure 15.39 11.82 13 124689 32208 90471537
Cyst 15.38 11.82 54 124648 16507 90487238
Quadriplegia 15.17 11.82 17 124685 2214 90501531
Vulval cancer 15.08 11.82 11 124691 817 90502928
Uterine haemorrhage 15.07 11.82 25 124677 4727 90499018
Cervical incompetence 15.07 11.82 10 124692 638 90503107
Invasive lobular breast carcinoma 15.06 11.82 12 124690 1017 90502728
Uterine leiomyosarcoma 15.06 11.82 4 124698 21 90503724
Carpal tunnel syndrome 14.98 11.82 69 124633 23859 90479886
Uterine polyp 14.89 11.82 18 124684 2542 90501203
Injection site hypoaesthesia 14.83 11.82 10 124692 655 90503090
Uterine cyst 14.81 11.82 9 124693 492 90503253
Spinal laminectomy 14.76 11.82 11 124691 845 90502900
Paraganglion neoplasm 14.75 11.82 4 124698 23 90503722
Colostomy infection 14.70 11.82 3 124699 3 90503742
Intestinal ulcer perforation 14.70 11.82 3 124699 3 90503742
Nasal sinus cancer 14.61 11.82 4 124698 24 90503721
Female sterilisation 14.59 11.82 10 124692 673 90503072
Product dose omission in error 14.56 11.82 5 124697 20498 90483247
Urinary bladder suspension 14.52 11.82 9 124693 510 90503235
Lung neoplasm 14.51 11.82 30 124672 6705 90497040
Shortened cervix 14.49 11.82 7 124695 241 90503504
Staphylococcal osteomyelitis 14.31 11.82 6 124696 147 90503598
Gastric ulcer haemorrhage 14.31 11.82 26 124676 5285 90498460
Complication of pregnancy 14.30 11.82 10 124692 695 90503050
Petit mal epilepsy 14.29 11.82 25 124677 4933 90498812
Arterial therapeutic procedure 14.21 11.82 4 124698 27 90503718
Serum serotonin decreased 14.21 11.82 4 124698 27 90503718
Cardiac valve disease 14.19 11.82 24 124678 4611 90499134
Spinal fracture 14.17 11.82 64 124638 21952 90481793
Hypersomnia 14.16 11.82 63 124639 21468 90482277
Blood pressure fluctuation 14.12 11.82 32 124670 52381 90451364
Lacrimation increased 14.09 11.82 10 124692 27052 90476693
Hypotonia 14.02 11.82 41 124661 11385 90492360
Therapeutic response shortened 13.96 11.82 7 124695 22872 90480873
Haemangioma 13.93 11.82 19 124683 3023 90500722
Hyperthyroidism 13.93 11.82 56 124646 18254 90485491
Ascites 13.82 11.82 28 124674 47712 90456033
Eye movement disorder 13.82 11.82 28 124674 6170 90497575
Cardiac procedure complication 13.74 11.82 6 124696 163 90503582
Decreased interest 13.73 11.82 23 124679 4384 90499361
Hepatic cirrhosis 13.72 11.82 43 124659 63210 90440535
Nodule 13.72 11.82 10 124692 26676 90477069
Carcinoid tumour of the stomach 13.70 11.82 6 124696 164 90503581
Abdominal operation 13.68 11.82 11 124691 945 90502800
Paraesthesia oral 13.67 11.82 14 124688 31645 90472100
Cervix carcinoma stage 0 13.62 11.82 9 124693 570 90503175
Withdrawal syndrome 13.58 11.82 7 124695 22517 90481228
Procedural haemorrhage 13.54 11.82 19 124683 3105 90500640
Automatic bladder 13.51 11.82 5 124697 87 90503658
Benign pancreatic neoplasm 13.51 11.82 4 124698 33 90503712
Cast application 13.51 11.82 4 124698 33 90503712
Product substitution issue 13.49 11.82 4 124698 18004 90485741
Ovarian adenoma 13.47 11.82 7 124695 282 90503463
Injection site discomfort 13.44 11.82 27 124675 5913 90497832
Injection site plaque 13.44 11.82 6 124696 172 90503573
Haematuria 13.41 11.82 17 124685 34920 90468825
Bronchiectasis 13.37 11.82 7 124695 22323 90481422
Hepatic adenoma 13.27 11.82 8 124694 431 90503314
Lymphoma 13.22 11.82 45 124657 13546 90490199
Injection site vesicles 13.19 11.82 22 124680 4178 90499567
Hepatotoxicity 13.17 11.82 27 124675 45815 90457930
Bacterial food poisoning 13.17 11.82 3 124699 7 90503738
Non-small cell lung cancer stage I 13.17 11.82 3 124699 7 90503738
Injection site erosion 13.15 11.82 5 124697 94 90503651
Brain neoplasm malignant 13.11 11.82 12 124690 1229 90502516
Muscle strain 13.10 11.82 36 124666 9651 90494094
Hepatic necrosis 13.08 11.82 28 124674 6410 90497335
Macular degeneration 13.05 11.82 20 124682 37950 90465795
Increased tendency to bruise 13.03 11.82 41 124661 11849 90491896
Migraine with aura 13.02 11.82 19 124683 3217 90500528
Pyelonephritis 13.00 11.82 61 124641 21255 90482490
Retinal vascular thrombosis 13.00 11.82 6 124696 186 90503559
Splenectomy 12.99 11.82 9 124693 616 90503129
Face oedema 12.98 11.82 8 124694 23310 90480435
Muscle contractions involuntary 12.97 11.82 18 124684 2910 90500835
Complication of delivery 12.97 11.82 6 124696 187 90503558
Cold type haemolytic anaemia 12.97 11.82 7 124695 305 90503440
Rales 12.83 11.82 3 124699 15824 90487921
Retinal haemorrhage 12.80 11.82 26 124676 5738 90498007
Back pain 12.78 11.82 546 124156 316629 90187116
Restless legs syndrome 12.77 11.82 63 124639 22407 90481338
Craniocerebral injury 12.75 11.82 19 124683 3279 90500466
Cystocele 12.74 11.82 13 124689 1521 90502224
Central nervous system inflammation 12.74 11.82 6 124696 195 90503550
Respiratory disorder 12.74 11.82 46 124656 64770 90438975
Diverticulitis 12.73 11.82 106 124596 45081 90458664
Paternal exposure before pregnancy 12.73 11.82 5 124697 103 90503642
Hepatic cyst 12.70 11.82 28 124674 6540 90497205
Gastric banding 12.68 11.82 5 124697 104 90503641
Ear pain 12.68 11.82 39 124663 57663 90446082
Mastitis 12.67 11.82 18 124684 2975 90500770
Hypertonic bladder 12.63 11.82 22 124680 4326 90499419
Lhermitte's sign 12.62 11.82 3 124699 9 90503736
Abdominal hernia 12.60 11.82 26 124676 5802 90497943
Post procedural swelling 12.58 11.82 8 124694 474 90503271
Orthostatic hypotension 12.57 11.82 24 124678 41803 90461942
Lipoma excision 12.56 11.82 4 124698 43 90503702
Sarcoma 12.50 11.82 9 124693 655 90503090
Large intestinal obstruction 12.50 11.82 17 124685 2697 90501048
Iatrogenic injury 12.45 11.82 10 124692 858 90502887
Gallbladder hypofunction 12.43 11.82 8 124694 484 90503261
Small cell lung cancer extensive stage 12.39 11.82 3 124699 10 90503735
Pain in jaw 12.37 11.82 30 124672 47955 90455790
Ovarian cancer recurrent 12.36 11.82 13 124689 1577 90502168
Gestational hypertension 12.35 11.82 18 124684 3044 90500701
Progressive relapsing multiple sclerosis 12.32 11.82 4 124698 46 90503699
Dysphemia 12.32 11.82 18 124684 3052 90500693
Breath sounds abnormal 12.31 11.82 3 124699 15383 90488362
Lung carcinoma cell type unspecified stage IV 12.28 11.82 12 124690 1334 90502411
Intracranial hypotension 12.27 11.82 7 124695 340 90503405
Benign ovarian tumour 12.27 11.82 8 124694 495 90503250
Joint injury 12.26 11.82 82 124620 32582 90471163
Intestinal cyst 12.25 11.82 6 124696 213 90503532
Injection site thrombosis 12.22 11.82 5 124697 115 90503630
Plasmapheresis 12.16 11.82 7 124695 346 90503399
Proctitis 12.16 11.82 3 124699 15256 90488489
Oophorectomy bilateral 12.14 11.82 5 124697 117 90503628
Myelopathy 12.12 11.82 19 124683 3425 90500320
Malignant melanoma stage I 12.09 11.82 4 124698 49 90503696
Splenic rupture 12.09 11.82 12 124690 1359 90502386
Post procedural haematoma 12.08 11.82 12 124690 1360 90502385
Incision site pain 12.04 11.82 12 124690 1366 90502379
Smear cervix abnormal 12.00 11.82 18 124684 3124 90500621
Oropharyngeal pain 12.00 11.82 101 124601 115086 90388659
Animal bite 11.99 11.82 18 124684 3125 90500620
Non-Hodgkin's lymphoma 11.98 11.82 12 124690 1374 90502371
Respiratory tract congestion 11.98 11.82 12 124690 27398 90476347
Immunodeficiency 11.97 11.82 26 124676 43208 90460537
Intestinal gangrene 11.96 11.82 3 124699 12 90503733
Heat exhaustion 11.87 11.82 6 124696 228 90503517
Postoperative wound complication 11.85 11.82 11 124691 1146 90502599
Inner ear disorder 11.85 11.82 9 124693 711 90503034
Pituitary tumour 11.85 11.82 10 124692 919 90502826

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Multiple sclerosis relapse 3490.74 15.94 971 29122 13293 42577949
Influenza like illness 1481.74 15.94 625 29468 31215 42560027
Gait disturbance 344.93 15.94 384 29709 97616 42493626
Central nervous system lesion 317.59 15.94 140 29953 7730 42583512
General symptom 312.54 15.94 84 30009 987 42590255
Injection site erythema 301.33 15.94 184 29909 20011 42571231
Fall 283.17 15.94 554 29539 233966 42357276
Memory impairment 253.18 15.94 239 29854 49983 42541259
Urinary tract infection 241.63 15.94 323 29770 98961 42492281
Balance disorder 236.84 15.94 225 29868 47420 42543822
Off label use 232.97 15.94 81 30012 638254 41952988
Muscle spasticity 226.67 15.94 106 29987 6716 42584526
Hypoaesthesia 212.55 15.94 257 29836 71206 42520036
Mobility decreased 187.45 15.94 173 29920 35133 42556109
Depression 179.82 15.94 299 29794 111064 42480178
Injection site pain 162.32 15.94 202 29891 57596 42533646
Injection site infection 157.91 15.94 50 30043 1076 42590166
Myocardial infarction 155.29 15.94 298 29795 123711 42467531
Needle fatigue 154.25 15.94 50 30043 1163 42590079
Relapsing-remitting multiple sclerosis 147.86 15.94 51 30042 1444 42589798
Progressive multiple sclerosis 143.86 15.94 34 30059 225 42591017
Cognitive disorder 141.21 15.94 146 29947 34026 42557216
Injection site reaction 139.94 15.94 104 29989 15617 42575625
Acute kidney injury 138.08 15.94 44 30049 367293 42223949
Gait inability 135.18 15.94 119 29974 22714 42568528
Optic neuritis 133.40 15.94 63 30030 4079 42587163
Muscular weakness 133.09 15.94 223 29870 83275 42507967
Secondary progressive multiple sclerosis 132.46 15.94 35 30058 383 42590859
Gait spastic 131.38 15.94 46 30047 1363 42589879
Toxicity to various agents 130.12 15.94 8 30085 229128 42362114
Drug interaction 126.40 15.94 19 30074 266980 42324262
Hypertonic bladder 121.35 15.94 50 30043 2331 42588911
Injection site cellulitis 120.66 15.94 36 30057 630 42590612
Loss of control of legs 116.16 15.94 37 30056 812 42590430
Magnetic resonance imaging abnormal 114.27 15.94 44 30049 1714 42589528
Diarrhoea 105.90 15.94 102 29991 460747 42130495
Monoparesis 104.56 15.94 48 30045 2912 42588330
Decubitus ulcer 99.31 15.94 72 30021 10405 42580837
Seizure 98.49 15.94 244 29849 120317 42470925
Injection site abscess 97.41 15.94 34 30059 998 42590244
Intervertebral disc protrusion 91.33 15.94 70 30023 11002 42580240
Ataxia 87.44 15.94 80 30013 16045 42575197
Neutropenia 86.03 15.94 18 30075 199413 42391829
Anaemia 83.71 15.94 47 30046 280231 42311011
Coronary artery occlusion 83.07 15.94 66 30027 10931 42580311
Road traffic accident 81.42 15.94 83 30010 19010 42572232
Multiple sclerosis 80.76 15.94 56 30037 7542 42583700
Dyspnoea 78.28 15.94 120 29973 442501 42148741
Coordination abnormal 77.84 15.94 56 30037 7994 42583248
Trigeminal neuralgia 76.75 15.94 32 30061 1537 42589705
Injection site induration 74.00 15.94 40 30053 3447 42587795
Cystitis 67.28 15.94 60 30033 11638 42579604
Hypotension 66.33 15.94 51 30042 257580 42333662
Injection site haematoma 64.20 15.94 30 30063 1895 42589347
Bladder disorder 63.72 15.94 37 30056 3662 42587580
Visual impairment 63.16 15.94 111 29982 43002 42548240
Movement disorder 62.86 15.94 64 30029 14634 42576608
Musculoskeletal disorder 61.50 15.94 45 30048 6593 42584649
Thrombocytopenia 61.07 15.94 29 30064 190250 42400992
Product use in unapproved indication 60.93 15.94 27 30066 184429 42406813
Dysarthria 60.28 15.94 104 29989 39703 42551539
Anxiety 59.89 15.94 202 29891 118358 42472884
Micturition urgency 56.78 15.94 55 30038 11843 42579399
Neurogenic bladder 53.83 15.94 28 30065 2232 42589010
Pain 53.42 15.94 325 29768 244523 42346719
Hyponatraemia 53.40 15.94 5 30088 101457 42489785
Injection site scar 50.87 15.94 17 30076 436 42590806
Injection site necrosis 49.80 15.94 18 30075 586 42590656
Muscle spasms 49.21 15.94 153 29940 85891 42505351
Adverse drug reaction 46.77 15.94 90 30003 37344 42553898
Amnesia 46.63 15.94 77 30016 28360 42562882
Drug delivery device placement 46.57 15.94 12 30081 118 42591124
Procedural anxiety 45.79 15.94 9 30084 20 42591222
Chills 45.49 15.94 158 29935 93908 42497334
Injection site bruising 45.35 15.94 48 30045 11477 42579765
Peroneal nerve palsy 44.88 15.94 29 30064 3473 42587769
Pollakiuria 43.91 15.94 66 30027 22439 42568803
Interstitial lung disease 43.70 15.94 3 30090 78459 42512783
Nocturia 43.38 15.94 48 30045 12064 42579178
Abdominal pain 42.59 15.94 43 30050 190428 42400814
Blood creatinine increased 41.50 15.94 13 30080 109990 42481252
Speech disorder 41.38 15.94 74 30019 29047 42562195
Hemiparesis 41.33 15.94 56 30037 17320 42573922
Cerebrovascular accident 40.89 15.94 156 29937 97004 42494238
Pancytopenia 40.84 15.94 16 30077 117727 42473515
Rash 40.78 15.94 84 30009 276870 42314372
Primary progressive multiple sclerosis 40.73 15.94 9 30084 42 42591200
Dysstasia 40.72 15.94 50 30043 14036 42577206
Product use issue 39.81 15.94 4 30089 76747 42514495
Hyperkalaemia 39.70 15.94 5 30088 80453 42510789
Bipolar disorder 39.56 15.94 28 30065 3894 42587348
Nausea 39.31 15.94 146 29947 396653 42194589
Asthenia 38.77 15.94 334 29759 280459 42310783
Renal impairment 38.20 15.94 15 30078 110213 42481029
Prostate cancer 38.13 15.94 92 30001 44551 42546691
Head injury 36.84 15.94 58 30035 20524 42570718
Drug abuse 36.73 15.94 14 30079 104757 42486485
Platelet count decreased 36.17 15.94 27 30066 138554 42452688
Injection site haemorrhage 36.11 15.94 43 30050 11693 42579549
Respiratory failure 36.05 15.94 23 30070 128109 42463133
Lower limb fracture 35.78 15.94 29 30064 4938 42586304
Pleural effusion 35.74 15.94 12 30081 97154 42494088
Insomnia 35.21 15.94 171 29922 118082 42473160
Glioblastoma 34.81 15.94 18 30075 1417 42589825
Paralysis 34.53 15.94 33 30060 6987 42584255
Spinal fusion surgery 34.45 15.94 17 30076 1212 42590030
Haemoglobin decreased 34.32 15.94 26 30067 132445 42458797
Tremor 33.92 15.94 147 29946 96782 42494460
Blindness unilateral 33.72 15.94 29 30064 5359 42585883
Decreased appetite 33.39 15.94 53 30040 193084 42398158
Testicular infarction 33.09 15.94 8 30085 59 42591183
Neutralising antibodies positive 32.50 15.94 9 30084 119 42591123
Erectile dysfunction 32.48 15.94 61 30032 24852 42566390
Generalised tonic-clonic seizure 32.43 15.94 63 30030 26316 42564926
Hypokalaemia 31.87 15.94 6 30087 71715 42519527
Cough 31.62 15.94 48 30045 178055 42413187
Staphylococcal infection 31.53 15.94 77 30016 37566 42553676
Hepatic enzyme increased 31.51 15.94 87 30006 45697 42545545
Paraparesis 31.19 15.94 19 30074 2052 42589190
Urinary incontinence 30.70 15.94 55 30038 21613 42569629
Adverse reaction 30.22 15.94 24 30069 3969 42587273
Drug specific antibody present 30.16 15.94 24 30069 3982 42587260
Headache 30.06 15.94 279 29814 239090 42352152
Tachycardia 30.03 15.94 17 30076 101070 42490172
Injury associated with device 29.57 15.94 16 30077 1381 42589861
Feeling abnormal 29.31 15.94 112 29981 69674 42521568
Multiple organ dysfunction syndrome 29.29 15.94 16 30077 97019 42494223
Influenza 28.80 15.94 103 29990 62072 42529170
Thyroid cancer 28.51 15.94 17 30076 1766 42589476
COVID-19 28.47 15.94 24 30069 115924 42475318
Agraphia 28.31 15.94 6 30087 22 42591220
Concussion 28.25 15.94 20 30073 2782 42588460
Paraesthesia 27.71 15.94 114 29979 73345 42517897
Post procedural complication 27.57 15.94 39 30054 12551 42578691
Progressive relapsing multiple sclerosis 27.35 15.94 5 30088 6 42591236
Pruritus 27.12 15.94 58 30035 188713 42402529
Muscle tightness 27.12 15.94 26 30067 5527 42585715
Hypoglycaemia 26.61 15.94 5 30088 59849 42531393
Septic shock 26.40 15.94 16 30077 91656 42499586
Nephrolithiasis 26.35 15.94 71 30022 36759 42554483
Superficial vein prominence 26.14 15.94 5 30088 9 42591233
Ankle fracture 26.10 15.94 24 30069 4842 42586400
Osteonecrosis 26.06 15.94 43 30050 15822 42575420
Intentional product misuse 25.81 15.94 6 30087 61894 42529348
C-reactive protein increased 24.90 15.94 7 30086 63553 42527689
Neutrophil count decreased 24.81 15.94 7 30086 63408 42527834
Ascites 24.64 15.94 5 30088 56673 42534569
Cardiac failure 24.00 15.94 24 30069 106832 42484410
Productive cough 23.59 15.94 4 30089 51563 42539679
Rhabdomyolysis 23.34 15.94 13 30080 78006 42513236
Frustration tolerance decreased 23.28 15.94 19 30074 3267 42587975
Dysgraphia 23.10 15.94 17 30076 2511 42588731
Hospitalisation 22.80 15.94 12 30081 74318 42516924
Cardiac valve rupture 22.79 15.94 4 30089 3 42591239
Neuropathy peripheral 22.73 15.94 23 30070 101830 42489412
Temperature intolerance 22.59 15.94 22 30071 4766 42586476
Suicidal ideation 22.48 15.94 80 30013 48081 42543161
Therapeutic product effect incomplete 22.44 15.94 11 30082 70928 42520314
Chronic lymphocytic leukaemia 22.43 15.94 22 30071 4807 42586435
Rectal haemorrhage 22.36 15.94 4 30089 49602 42541640
Anger 22.35 15.94 36 30057 12982 42578260
Sensory disturbance 22.05 15.94 26 30067 6997 42584245
Intervertebral disc disorder 22.04 15.94 15 30078 1959 42589283
Lactic acidosis 21.87 15.94 3 30090 45258 42545984
Mood swings 21.83 15.94 29 30064 8797 42582445
Injection site atrophy 21.55 15.94 6 30087 81 42591161
Intentional product use issue 21.45 15.94 12 30081 71821 42519421
Injection site inflammation 21.37 15.94 12 30081 1114 42590128
Gastrointestinal haemorrhage 20.77 15.94 23 30070 97703 42493539
Hip arthroplasty 20.70 15.94 22 30071 5283 42585959
Ophthalmoplegia 20.57 15.94 15 30078 2185 42589057
Diplegia 20.10 15.94 12 30081 1250 42589992
Lack of injection site rotation 19.98 15.94 9 30084 522 42590720
Urosepsis 19.85 15.94 37 30056 14983 42576259
Neurofibroma 19.75 15.94 4 30089 11 42591231
Wheezing 19.73 15.94 7 30086 54774 42536468
Somnolence 19.72 15.94 44 30049 141061 42450181
Hernia 19.53 15.94 31 30062 11042 42580200
Injection site injury 19.47 15.94 8 30085 370 42590872
Injection site mass 19.43 15.94 27 30066 8548 42582694
Overweight 19.34 15.94 15 30078 2397 42588845
Injection site ulcer 19.19 15.94 8 30085 384 42590858
Anal incontinence 19.00 15.94 28 30065 9353 42581889
Hypoxia 18.97 15.94 13 30080 69773 42521469
Appendicitis perforated 18.88 15.94 14 30079 2092 42589150
Stomatitis 18.88 15.94 6 30087 50323 42540919
Epistaxis 18.77 15.94 12 30081 66814 42524428
B-cell lymphoma stage I 18.77 15.94 3 30090 0 42591242
Cholelithiasis 18.75 15.94 47 30046 23299 42567943
Diabetes mellitus 18.67 15.94 88 30005 59999 42531243
Feeling cold 18.47 15.94 33 30060 12940 42578302
Glioblastoma multiforme 18.39 15.94 10 30083 872 42590370
Scar 18.14 15.94 23 30070 6665 42584577
Vaccination complication 17.99 15.94 5 30088 67 42591175
Hepatic function abnormal 17.88 15.94 7 30086 51560 42539682
Vision blurred 17.68 15.94 80 30013 53619 42537623
Depressed mood 17.66 15.94 46 30047 23338 42567904
Oxygen saturation decreased 17.65 15.94 12 30081 64675 42526567
Vomiting 17.61 15.94 126 29967 289597 42301645
Back disorder 17.54 15.94 24 30069 7490 42583752
Mood altered 17.54 15.94 29 30064 10689 42580553
Blindness 17.48 15.94 39 30054 17939 42573303
Pneumonitis 17.48 15.94 4 30089 41714 42549528
Weight increased 17.38 15.94 31 30062 107952 42483290
Thrombocytopenic purpura 17.33 15.94 11 30082 1278 42589964
Fear of injection 17.26 15.94 13 30080 1990 42589252
Cardio-respiratory arrest 17.21 15.94 10 30083 58626 42532616
Overdose 17.14 15.94 30 30063 105234 42486008
Injection site irritation 17.06 15.94 12 30081 1652 42589590
JC polyomavirus test positive 16.93 15.94 10 30083 1021 42590221
Maternal drugs affecting foetus 16.93 15.94 17 30076 3822 42587420
Umbilical cord around neck 16.91 15.94 6 30087 185 42591057
Surgery 16.89 15.94 38 30055 17578 42573664
Cellulitis 16.85 15.94 87 30006 61498 42529744
Neutralising antibodies 16.69 15.94 3 30090 3 42591239
Therapeutic response decreased 16.65 15.94 3 30090 37009 42554233
Fatigue 16.48 15.94 413 29680 435228 42156014
Drug ineffective for unapproved indication 16.45 15.94 6 30087 46157 42545085
Hip fracture 16.34 15.94 32 30061 13440 42577802
Peripheral swelling 16.32 15.94 24 30069 90246 42500996
Brain neoplasm 16.10 15.94 16 30077 3552 42587690
Motor dysfunction 16.04 15.94 24 30069 8122 42583120

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Multiple sclerosis relapse 9590.11 12.21 3034 104269 47206 110434790
Influenza like illness 4464.54 12.21 2020 105283 86392 110395604
Fall 1205.57 12.21 2121 105182 601361 109880635
Off label use 876.10 12.21 195 107108 1499990 108982006
Gait disturbance 799.04 12.21 1156 106147 277052 110204944
Breast cancer 798.75 12.21 486 106817 38056 110443940
Urinary tract infection 668.89 12.21 1162 106141 325120 110156876
Central nervous system lesion 642.47 12.21 310 106993 15243 110466753
Balance disorder 620.50 12.21 661 106642 115899 110366097
Optic neuritis 552.49 12.21 252 107051 10895 110471101
Injection site erythema 529.57 12.21 550 106753 93626 110388370
General symptom 512.19 12.21 223 107080 8623 110473373
Injection site pain 489.43 12.21 725 106578 177197 110304799
Seizure 487.46 12.21 814 106489 220371 110261625
Depression 449.58 12.21 967 106336 316368 110165628
Loss of control of legs 406.29 12.21 129 107174 2003 110479993
Intervertebral disc protrusion 403.38 12.21 280 107023 27418 110454578
Memory impairment 362.70 12.21 670 106633 196274 110285722
Myocardial infarction 354.39 12.21 654 106649 191429 110290567
Toxicity to various agents 344.12 12.21 34 107269 480521 110001475
Hypoaesthesia 329.85 12.21 852 106451 313371 110168625
Secondary progressive multiple sclerosis 307.55 12.21 97 107206 1472 110480524
Product use in unapproved indication 299.43 12.21 40 107263 447337 110034659
Magnetic resonance imaging abnormal 293.87 12.21 119 107184 3826 110478170
Injection site bruising 290.93 12.21 301 107002 50962 110431034
Decubitus ulcer 281.23 12.21 191 107112 18045 110463951
Drug interaction 274.83 12.21 73 107230 500110 109981886
Muscle spasticity 273.75 12.21 248 107055 35667 110446329
Diarrhoea 266.97 12.21 435 106868 1139070 109342926
Febrile neutropenia 256.84 12.21 12 107291 316755 110165241
Uterine leiomyoma 253.01 12.21 132 107171 7668 110474328
Muscular weakness 246.59 12.21 660 106643 247808 110234188
Acute kidney injury 245.78 12.21 157 107146 635273 109846723
Injection site haemorrhage 245.73 12.21 225 107078 32803 110449193
Synovitis 245.48 12.21 4 107299 274088 110207908
Ankle fracture 244.16 12.21 181 107122 19638 110462358
Product use issue 242.76 12.21 15 107288 311680 110170316
Coronary artery occlusion 242.76 12.21 165 107138 15607 110466389
Rash 232.51 12.21 273 107030 820691 109661305
Stress 225.50 12.21 383 106920 104965 110377031
Abortion spontaneous 223.39 12.21 217 107086 34065 110447931
Hysterectomy 220.29 12.21 122 107181 7992 110474004
Breast cancer female 214.98 12.21 140 107163 12328 110469668
Injection site infection 213.23 12.21 84 107219 2509 110479487
Contraindicated product administered 212.99 12.21 6 107297 248261 110233735
Cerebrovascular accident 212.53 12.21 513 106790 180771 110301225
Trigeminal neuralgia 208.15 12.21 96 107207 4256 110477740
Musculoskeletal disorder 208.01 12.21 174 107129 22490 110459506
Injection site cellulitis 203.98 12.21 76 107227 1944 110480052
Progressive multiple sclerosis 199.24 12.21 67 107236 1257 110480739
Drug ineffective 197.93 12.21 784 106519 1519756 108962240
Neutropenia 197.65 12.21 59 107244 374561 110107435
Chills 196.89 12.21 514 106789 190066 110291930
Infusion related reaction 195.77 12.21 63 107240 381099 110100897
Relapsing-remitting multiple sclerosis 194.51 12.21 74 107229 2008 110479988
Stomatitis 191.02 12.21 20 107283 270222 110211774
Injection site abscess 186.34 12.21 71 107232 1935 110480061
Therapeutic product effect incomplete 186.32 12.21 7 107296 223798 110258198
Urinary incontinence 183.41 12.21 231 107072 48356 110433640
Dyspnoea 179.00 12.21 519 106784 1106353 109375643
Glossodynia 174.90 12.21 10 107293 221994 110260002
Hip fracture 172.27 12.21 191 107112 34960 110447036
Injection site reaction 167.53 12.21 306 106997 88764 110393232
Joint swelling 163.56 12.21 115 107188 442730 110039266
Psoriatic arthropathy 160.93 12.21 7 107296 196754 110285242
Gait inability 159.87 12.21 386 106917 135990 110346006
Intentional product use issue 156.91 12.21 26 107277 247880 110234116
Bladder disorder 156.09 12.21 110 107193 11027 110470969
Injection site haematoma 155.32 12.21 83 107220 5063 110476933
Multiple sclerosis 155.06 12.21 156 107147 25542 110456454
Cystitis 154.59 12.21 250 107053 65786 110416210
C-reactive protein increased 154.32 12.21 16 107287 217903 110264093
Caesarean section 154.28 12.21 119 107184 13698 110468298
Post procedural complication 153.88 12.21 158 107145 26500 110455496
Head injury 150.55 12.21 197 107106 42820 110439176
Wheezing 150.38 12.21 32 107271 255198 110226798
Cognitive disorder 150.08 12.21 289 107014 87222 110394774
Peroneal nerve palsy 149.70 12.21 92 107211 7322 110474674
Thyroid cancer 148.62 12.21 86 107217 6128 110475868
Coordination abnormal 144.67 12.21 149 107154 25079 110456917
Injection site necrosis 144.48 12.21 57 107246 1709 110480287
Malignant neoplasm progression 143.46 12.21 6 107297 174561 110307435
Rheumatoid arthritis 142.74 12.21 56 107247 299557 110182439
Helicobacter infection 140.82 12.21 9 107294 181868 110300128
Pericarditis 138.62 12.21 23 107280 219091 110262905
Needle fatigue 136.63 12.21 50 107253 1214 110480782
Lower respiratory tract infection 136.22 12.21 34 107269 243072 110238924
General physical health deterioration 135.20 12.21 128 107175 425167 110056829
Peripheral swelling 132.70 12.21 118 107185 403916 110078080
Abdominal pain 132.10 12.21 183 107120 512806 109969190
Folliculitis 130.68 12.21 8 107295 167645 110314351
Tremor 128.46 12.21 460 106843 201772 110280224
Upper limb fracture 128.23 12.21 128 107175 20760 110461236
Gait spastic 126.74 12.21 50 107253 1499 110480497
Neurogenic bladder 126.03 12.21 72 107231 5007 110476989
Pancytopenia 124.05 12.21 26 107277 209587 110272409
Breast cancer in situ 120.59 12.21 45 107258 1156 110480840
Drug hypersensitivity 119.91 12.21 159 107144 453931 110028065
Pruritus 118.74 12.21 241 107062 581319 109900677
Dysstasia 116.88 12.21 152 107151 32834 110449162
Hyponatraemia 115.24 12.21 34 107269 217619 110264377
Abdominal discomfort 114.45 12.21 128 107175 393730 110088266
Drug abuse 113.61 12.21 18 107285 177393 110304603
Invasive ductal breast carcinoma 113.05 12.21 74 107229 6572 110475424
Hypotension 112.19 12.21 211 107092 523638 109958358
Nephrolithiasis 111.49 12.21 217 107086 65995 110416001
Oedema 110.80 12.21 33 107270 209943 110272053
Treatment failure 110.46 12.21 66 107237 277168 110204828
Diabetes mellitus 109.77 12.21 275 107028 99106 110382890
Muscle spasms 109.67 12.21 547 106756 277610 110204386
Therapeutic product effect decreased 109.41 12.21 50 107253 244266 110237730
Muscle injury 108.90 12.21 7 107296 140800 110341196
Injection site scar 108.24 12.21 41 107262 1099 110480897
Cholelithiasis 108.18 12.21 209 107094 63213 110418783
Hyperkalaemia 107.30 12.21 6 107297 135790 110346206
Systemic lupus erythematosus 106.42 12.21 57 107246 254281 110227715
Asthenia 103.50 12.21 1072 106231 687927 109794069
Decreased appetite 99.83 12.21 194 107109 475652 110006344
Staphylococcal infection 99.73 12.21 214 107089 69730 110412266
Blister 99.55 12.21 48 107255 227328 110254668
Malignant melanoma 99.09 12.21 101 107202 16790 110465206
Completed suicide 98.97 12.21 56 107247 242325 110239671
Hemiparesis 98.40 12.21 163 107140 43740 110438256
Thrombocytopenia 97.45 12.21 117 107186 348768 110133228
Blood creatinine increased 96.03 12.21 29 107274 182860 110299136
Intracranial aneurysm 95.33 12.21 60 107243 4980 110477016
Ataxia 94.84 12.21 131 107172 29977 110452019
Injection site induration 93.46 12.21 82 107221 11301 110470695
Ovarian cancer 92.47 12.21 56 107247 4340 110477656
Feeling abnormal 91.78 12.21 383 106920 180328 110301668
Micturition urgency 89.57 12.21 102 107201 19218 110462778
Speech disorder 88.50 12.21 189 107114 61380 110420616
Injection site mass 88.11 12.21 114 107189 24499 110457497
Sensory disturbance 87.63 12.21 96 107207 17333 110464663
Nausea 86.20 12.21 776 106527 1234914 109247082
Cough 86.14 12.21 201 107102 461440 110020556
Kidney infection 86.12 12.21 115 107188 25484 110456512
Blindness unilateral 83.38 12.21 72 107231 9714 110472282
Monoparesis 83.12 12.21 53 107250 4500 110477496
Anxiety 82.82 12.21 596 106707 344482 110137514
Anaemia 82.76 12.21 264 107039 546822 109935174
Visual impairment 82.12 12.21 302 107001 134126 110347870
Drug delivery device placement 81.42 12.21 22 107281 186 110481810
Interstitial lung disease 80.96 12.21 18 107285 139316 110342680
Hypertonic bladder 80.47 12.21 55 107248 5247 110476749
Dry mouth 80.47 12.21 47 107256 199901 110282095
Electrocardiogram QT prolonged 77.12 12.21 8 107295 108952 110373044
Generalised tonic-clonic seizure 76.46 12.21 166 107137 54514 110427482
Wound 76.28 12.21 69 107234 234368 110247628
Mobility decreased 75.95 12.21 441 106862 236981 110245015
Road traffic accident 75.73 12.21 253 107050 107145 110374851
Gastric bypass 75.28 12.21 34 107269 1435 110480561
COVID-19 74.08 12.21 77 107226 244983 110237013
Mucosal inflammation 73.69 12.21 5 107298 96136 110385860
Concussion 73.22 12.21 72 107231 11466 110470530
Intervertebral disc degeneration 73.08 12.21 89 107214 17996 110464000
Scar 73.02 12.21 86 107217 16795 110465201
Intervertebral disc disorder 71.63 12.21 52 107251 5460 110476536
Facet joint syndrome 71.48 12.21 6 107297 96822 110385174
Loss of personal independence in daily activities 71.47 12.21 28 107275 149992 110332004
Irritable bowel syndrome 71.36 12.21 35 107268 164180 110317816
Neuromyelitis optica spectrum disorder 71.15 12.21 33 107270 1482 110480514
Appendicitis perforated 70.39 12.21 44 107259 3608 110478388
Cellulitis 70.28 12.21 275 107028 125741 110356255
Inflammation 70.18 12.21 51 107252 193187 110288809
Intentional product misuse 69.90 12.21 21 107282 132883 110349113
Swelling 69.42 12.21 148 107155 350893 110131103
Endometriosis 68.26 12.21 46 107257 4288 110477708
Hypokalaemia 67.78 12.21 47 107256 182401 110299595
Lumbar spinal stenosis 66.62 12.21 53 107250 6380 110475616
Metabolic acidosis 66.44 12.21 9 107294 99735 110382261
Joint range of motion decreased 66.38 12.21 18 107285 121814 110360182
Breast cancer stage I 66.30 12.21 56 107247 7331 110474665
Bipolar disorder 66.28 12.21 61 107242 8946 110473050
Paraparesis 66.09 12.21 46 107257 4520 110477476
Lung neoplasm malignant 65.81 12.21 118 107185 33724 110448272
Headache 65.31 12.21 1210 106093 881167 109600829
Lactic acidosis 65.20 12.21 7 107296 92804 110389192
Influenza 64.80 12.21 330 106973 168771 110313225
Spinal stenosis 64.70 12.21 86 107217 18970 110463026
Amnesia 64.53 12.21 237 107066 105171 110376825
Fatigue 64.42 12.21 1588 105715 1214370 109267626
Adverse drug reaction 64.34 12.21 237 107066 105322 110376674
Myelosuppression 64.07 12.21 8 107295 94332 110387664
Multiple organ dysfunction syndrome 63.44 12.21 34 107269 151676 110330320
Thrombosis 62.11 12.21 239 107064 108423 110373573
Neutrophil count decreased 62.00 12.21 20 107283 120921 110361075
Dysarthria 61.83 12.21 201 107102 83920 110398076
Drug specific antibody present 61.83 12.21 57 107246 8377 110473619
Therapeutic response decreased 61.30 12.21 10 107293 96489 110385507
Tachycardia 61.16 12.21 78 107225 226567 110255429
Gallbladder disorder 61.05 12.21 88 107215 20941 110461055
Procedural anxiety 60.81 12.21 25 107278 836 110481160
Injury associated with device 60.69 12.21 43 107260 4346 110477650
Bursitis 60.66 12.21 25 107278 129893 110352103
Renal impairment 60.66 12.21 56 107247 188389 110293607
Psoriasis 60.58 12.21 30 107273 139963 110342033
Vision blurred 59.76 12.21 266 107037 128756 110353240
Lung disorder 59.75 12.21 52 107251 179995 110302001
Dyspnoea exertional 59.34 12.21 14 107289 104046 110377950
Pollakiuria 59.33 12.21 132 107171 44063 110437933
Paralysis 58.59 12.21 74 107229 15526 110466470
Temperature intolerance 58.57 12.21 70 107233 13880 110468116
Intraductal proliferative breast lesion 58.53 12.21 36 107267 2869 110479127
Surgery 58.49 12.21 126 107177 41157 110440839
Liver injury 58.22 12.21 37 107266 150376 110331620
Drug intolerance 58.10 12.21 201 107102 406311 110075685
Dysgraphia 58.01 12.21 43 107260 4662 110477334
Tibia fracture 57.22 12.21 49 107254 6536 110475460
Injection site ulcer 56.92 12.21 24 107279 856 110481140
Injury 56.67 12.21 53 107250 177212 110304784
Oxygen saturation decreased 56.27 12.21 42 107261 156940 110325056
Pleural effusion 55.80 12.21 54 107249 177655 110304341
Drug reaction with eosinophilia and systemic symptoms 55.66 12.21 7 107296 82088 110399908
Meningioma benign 55.61 12.21 18 107285 298 110481698
Cervical spinal stenosis 55.58 12.21 35 107268 2907 110479089
Procedural pain 55.58 12.21 113 107190 35452 110446544
Hospitalisation 55.23 12.21 35 107268 142458 110339538
Injection site atrophy 54.91 12.21 20 107283 479 110481517
Postoperative wound infection 54.89 12.21 72 107231 15681 110466315
Hypoglycaemia 54.76 12.21 22 107281 116082 110365914
Ligament rupture 54.57 12.21 39 107264 3996 110478000
Arthralgia 54.45 12.21 489 106814 779143 109702853
Melaena 54.43 12.21 3 107300 68754 110413242
Feeling cold 54.32 12.21 109 107194 33878 110448118
Nerve compression 53.67 12.21 60 107243 11077 110470919
Basedow's disease 53.65 12.21 16 107287 199 110481797
Intentional overdose 53.51 12.21 31 107272 132470 110349526
Burning sensation 53.25 12.21 168 107135 69044 110412952
Cervix carcinoma 52.97 12.21 32 107271 2469 110479527
Pulmonary thrombosis 52.44 12.21 66 107237 13797 110468199
Muscle tightness 52.26 12.21 68 107235 14694 110467302
Foot fracture 52.16 12.21 91 107212 25455 110456541
Pain in extremity 51.82 12.21 710 106593 486408 109995588
Alopecia 51.68 12.21 181 107122 364572 110117424
Movement disorder 51.45 12.21 111 107192 36293 110445703
Vomiting 51.35 12.21 601 106702 910074 109571922
Loss of consciousness 51.12 12.21 346 106957 195960 110286036
Drug ineffective for unapproved indication 50.99 12.21 18 107285 102820 110379176
Ovarian cyst 50.61 12.21 65 107238 13865 110468131
Meniscus injury 50.14 12.21 49 107254 7744 110474252
Cholecystectomy 49.99 12.21 57 107246 10752 110471244
Sleep disorder 49.91 12.21 72 107231 198572 110283424
Focal dyscognitive seizures 49.31 12.21 36 107267 3813 110478183
Product quality issue 49.12 12.21 8 107295 77291 110404705
Fibromyalgia 49.09 12.21 56 107247 170853 110311143
Papillary thyroid cancer 48.68 12.21 32 107271 2862 110479134
Diplopia 48.43 12.21 118 107185 41776 110440220
Hypocalcaemia 48.39 12.21 4 107299 65362 110416634
Medication error 48.03 12.21 21 107282 105345 110376651
Urosepsis 47.38 12.21 97 107206 30578 110451418
Grip strength decreased 47.30 12.21 10 107293 80164 110401832
Delirium 47.27 12.21 37 107266 134988 110347008
Hypoxia 47.26 12.21 34 107269 129481 110352515
Rectal haemorrhage 47.04 12.21 29 107274 119804 110362192
Suicidal ideation 46.81 12.21 198 107105 93739 110388257
Hypomagnesaemia 46.68 12.21 3 107300 60367 110421629
Platelet count decreased 46.50 12.21 96 107207 230347 110251649
Haemoglobin decreased 45.78 12.21 109 107194 248618 110233378
Prescribed overdose 45.76 12.21 14 107289 87567 110394429
Blood pressure systolic increased 45.70 12.21 12 107291 82979 110399017
Procedural complication 45.25 12.21 48 107255 8357 110473639
Colon cancer 45.11 12.21 67 107236 16376 110465620
Paraesthesia 45.10 12.21 438 106865 276083 110205913
Haemorrhage in pregnancy 45.06 12.21 25 107278 1643 110480353
Peripheral venous disease 44.76 12.21 13 107290 84104 110397892
Gastrointestinal haemorrhage 44.61 12.21 57 107246 165461 110316535
Injection site inflammation 44.54 12.21 37 107266 4734 110477262
Neutralising antibodies positive 44.37 12.21 16 107287 372 110481624
Primary progressive multiple sclerosis 44.14 12.21 12 107291 104 110481892
Rotator cuff syndrome 44.03 12.21 67 107236 16727 110465269
Pulmonary fibrosis 43.95 12.21 22 107281 102020 110379976
Wound infection staphylococcal 43.94 12.21 32 107271 3377 110478619
Fibula fracture 43.64 12.21 36 107267 4562 110477434
Ill-defined disorder 43.33 12.21 53 107250 156800 110325196
Osteonecrosis 43.31 12.21 99 107204 33642 110448354
Facial bones fracture 43.21 12.21 37 107266 4934 110477062
Vertigo 43.20 12.21 183 107120 86687 110395309
Illness 43.17 12.21 13 107290 82158 110399838
Productive cough 43.04 12.21 29 107274 114276 110367720
Mental impairment 42.82 12.21 78 107225 22561 110459435
Septic shock 42.71 12.21 54 107249 157474 110324522
Overdose 42.60 12.21 103 107200 233691 110248305
Disease progression 42.53 12.21 110 107193 243924 110238072
Dyspepsia 42.51 12.21 75 107228 190890 110291106
Retinal exudates 42.42 12.21 22 107281 1262 110480734
Coronary artery disease 42.05 12.21 159 107144 71531 110410465
Injection site irritation 41.49 12.21 36 107267 4888 110477108
Spinal disorder 41.48 12.21 54 107249 11674 110470322
Liver function test increased 41.40 12.21 17 107286 88531 110393465
Haematochezia 41.28 12.21 31 107272 115493 110366503
Meningioma 40.97 12.21 38 107265 5627 110476369
Dry skin 40.95 12.21 27 107276 107626 110374370
Rhabdomyolysis 40.89 12.21 34 107269 120367 110361629
Thyroid disorder 40.73 12.21 65 107238 16904 110465092
Respiratory failure 40.72 12.21 93 107210 215239 110266757
Therapy non-responder 40.53 12.21 56 107247 157251 110324745
Hernia 40.51 12.21 70 107233 19430 110462566
Appendicitis 40.46 12.21 87 107216 28377 110453619
Agraphia 40.42 12.21 10 107293 57 110481939
Blood potassium decreased 40.39 12.21 130 107173 53984 110428012
Thyroid neoplasm 40.32 12.21 30 107273 3271 110478725
Serotonin syndrome 40.21 12.21 5 107298 59148 110422848
International normalised ratio increased 40.02 12.21 17 107286 86755 110395241
Skin laceration 40.01 12.21 96 107207 33657 110448339
Frequent bowel movements 39.93 12.21 10 107293 71380 110410616
Hypertension 38.85 12.21 703 106600 509381 109972615
Cardiac failure 38.85 12.21 77 107226 187549 110294447
Mammoplasty 38.72 12.21 15 107288 428 110481568
Ruptured cerebral aneurysm 38.56 12.21 17 107286 677 110481319
Rash maculo-papular 38.53 12.21 12 107291 74210 110407786
Sedation 38.52 12.21 10 107293 69673 110412323
Ascites 38.50 12.21 21 107282 92787 110389209
Breast cancer recurrent 38.37 12.21 31 107272 3815 110478181
Endometrial cancer 38.33 12.21 26 107277 2450 110479546
Nasal congestion 38.27 12.21 24 107279 98258 110383738
Uterine cancer 38.20 12.21 32 107271 4142 110477854
Liver function test abnormal 38.05 12.21 150 107153 68800 110413196
Glioblastoma 37.87 12.21 24 107279 2016 110479980
Breech presentation 37.41 12.21 17 107286 728 110481268
Prolonged labour 37.37 12.21 15 107288 471 110481525
Night sweats 37.30 12.21 45 107258 133938 110348058
Aphasia 37.24 12.21 134 107169 58863 110423133
Accidental exposure to product 37.18 12.21 3 107300 50005 110431991
Injection site discolouration 37.11 12.21 45 107258 9058 110472938
Nail disorder 36.80 12.21 6 107297 57929 110424067
Red blood cell sedimentation rate increased 36.66 12.21 15 107288 78287 110403709
Arthropathy 36.61 12.21 149 107154 287373 110194623
Injection site scab 36.46 12.21 16 107287 630 110481366
Gastrointestinal disorder 36.35 12.21 117 107186 241835 110240161
Neuropathy peripheral 35.90 12.21 75 107228 179202 110302794
Agranulocytosis 35.83 12.21 8 107295 61752 110420244
Rib fracture 35.76 12.21 92 107211 33678 110448318
Phobia 35.57 12.21 14 107289 417 110481579
Colon cancer stage III 35.32 12.21 13 107290 321 110481675
Appendicectomy 35.13 12.21 28 107275 3379 110478617
Ligament sprain 35.12 12.21 59 107244 16009 110465987
Dehydration 35.01 12.21 420 106883 279091 110202905
Discomfort 34.99 12.21 100 107203 214607 110267389
Muscle atrophy 34.92 12.21 53 107250 13201 110468795
Cartilage injury 34.61 12.21 21 107282 1633 110480363
Drug dependence 34.56 12.21 4 107299 50016 110431980
Inappropriate schedule of product administration 34.55 12.21 93 107210 203544 110278452
Band sensation 34.27 12.21 18 107285 1060 110480936
Clostridial infection 33.94 12.21 36 107267 6266 110475730
Weight increased 33.90 12.21 253 107050 419391 110062605
Bone erosion 33.88 12.21 3 107300 46368 110435628
Cytomegalovirus infection 33.79 12.21 6 107297 54438 110427558
Frustration tolerance decreased 33.72 12.21 42 107261 8689 110473307
Pneumonitis 33.71 12.21 16 107287 76515 110405481
Tubulointerstitial nephritis 33.65 12.21 6 107297 54278 110427718
JC polyomavirus test 33.56 12.21 8 107295 38 110481958
Anal incontinence 33.39 12.21 69 107234 21895 110460101
Depressed mood 33.32 12.21 132 107171 60677 110421319
Haemolytic uraemic syndrome 33.30 12.21 32 107271 4953 110477043
Injection site nodule 33.28 12.21 31 107272 4615 110477381
Rectocele 33.25 12.21 16 107287 781 110481215
Autoimmune hepatitis 33.22 12.21 55 107248 14749 110467247
Cardio-respiratory arrest 33.21 12.21 38 107265 115798 110366198
Incorrect dose administered 33.10 12.21 31 107272 103610 110378386
Fear 33.09 12.21 71 107232 23122 110458874
Diplegia 33.06 12.21 23 107280 2258 110479738
Lack of injection site rotation 32.94 12.21 18 107285 1148 110480848
Panic attack 32.90 12.21 81 107222 28859 110453137
Benign lung neoplasm 32.71 12.21 10 107293 136 110481860
Blood creatine phosphokinase increased 32.62 12.21 15 107288 73062 110408934
Cellulitis staphylococcal 32.45 12.21 19 107284 1384 110480612
Blindness 32.44 12.21 93 107210 36266 110445730
Vein disorder 32.33 12.21 35 107268 6235 110475761
Upper gastrointestinal haemorrhage 32.25 12.21 5 107298 50091 110431905
Gallbladder operation 32.07 12.21 23 107280 2370 110479626
Erythema 31.73 12.21 160 107143 291287 110190709
Brain neoplasm benign 31.69 12.21 11 107292 228 110481768
Lower limb fracture 31.66 12.21 151 107152 75197 110406799
Knee arthroplasty 31.66 12.21 136 107167 64812 110417184
Wrist fracture 31.59 12.21 53 107250 14364 110467632
Benign breast neoplasm 31.59 12.21 16 107287 873 110481123
Crying 31.58 12.21 74 107229 25554 110456442
Femur fracture 31.55 12.21 105 107198 44364 110437632
Abdominal distension 31.22 12.21 78 107225 175025 110306971
Obstructive airways disorder 31.12 12.21 4 107299 46145 110435851
Expanded disability status scale score increased 31.11 12.21 16 107287 902 110481094
Malaise 30.93 12.21 862 106441 670957 109811039
Testicular infarction 30.93 12.21 8 107295 56 110481940
Paraplegia 30.91 12.21 34 107269 6166 110475830
Goitre 30.89 12.21 34 107269 6170 110475826
Onychomadesis 30.69 12.21 4 107299 45659 110436337
Crohn's disease 30.60 12.21 21 107282 2017 110479979
Hypercholesterolaemia 30.42 12.21 26 107277 90811 110391185
Brain neoplasm 30.30 12.21 34 107269 6303 110475693
Central venous catheterisation 30.19 12.21 27 107276 3815 110478181
Type 2 diabetes mellitus 30.02 12.21 81 107222 177151 110304845
Cholecystitis 30.02 12.21 73 107230 25809 110456187
Mental disorder 29.69 12.21 94 107209 38697 110443299
Pelvic fracture 29.65 12.21 51 107252 14103 110467893
Abnormal labour 29.40 12.21 6 107297 11 110481985
Abdominal pain upper 29.38 12.21 208 107095 348903 110133093
Accident 29.15 12.21 44 107259 10908 110471088
Depressed level of consciousness 28.89 12.21 40 107263 112238 110369758
Intervertebral disc operation 28.77 12.21 16 107287 1056 110480940
Renal cell carcinoma 28.72 12.21 36 107267 7494 110474502
Back disorder 28.66 12.21 63 107240 20859 110461137
Thermal burn 28.59 12.21 37 107266 7951 110474045
Chronic lymphocytic leukaemia 28.50 12.21 32 107271 5936 110476060
Pulmonary sarcoidosis 28.37 12.21 19 107284 1753 110480243
Blepharospasm 28.24 12.21 9 107294 54842 110427154
Progesterone receptor assay positive 28.00 12.21 10 107293 226 110481770
Cervical vertebral fracture 27.86 12.21 28 107275 4577 110477419
Pre-eclampsia 27.78 12.21 38 107265 8612 110473384
Eczema 27.67 12.21 18 107285 72275 110409721
Product administered at inappropriate site 27.62 12.21 30 107273 5363 110476633
Injection site swelling 27.56 12.21 126 107177 61664 110420332
Migraine 27.53 12.21 271 107032 171381 110310615
Post procedural haemorrhage 27.53 12.21 52 107251 15460 110466536
Colostomy closure 27.42 12.21 9 107294 156 110481840
Cardiac disorder 27.22 12.21 146 107157 76134 110405862
Breast calcifications 27.19 12.21 15 107288 975 110481021
Malignant hypertension 27.15 12.21 18 107285 1633 110480363
Constipation 26.88 12.21 220 107083 357566 110124430
Spinal osteoarthritis 26.77 12.21 60 107243 20123 110461873
Back pain 26.71 12.21 507 106796 370489 110111507
Nocturia 26.56 12.21 54 107249 16936 110465060
Oestrogen receptor assay positive 26.53 12.21 11 107292 376 110481620
Visual acuity reduced 26.51 12.21 80 107223 32093 110449903
X-ray abnormal 26.45 12.21 3 107300 38114 110443882
Mouth ulceration 26.43 12.21 7 107296 48131 110433865
Fractured coccyx 26.39 12.21 16 107287 1242 110480754
Lung adenocarcinoma 26.38 12.21 39 107264 9492 110472504
Asthma 26.34 12.21 139 107164 250152 110231844
Post procedural stroke 26.29 12.21 8 107295 107 110481889
Volvulus 26.22 12.21 24 107279 3494 110478502
Ectopic pregnancy 26.12 12.21 20 107283 2277 110479719
Breast cancer stage III 26.06 12.21 23 107280 79094 110402902
Ophthalmoplegia 26.04 12.21 24 107279 3526 110478470
Emotional disorder 26.03 12.21 52 107251 16108 110465888
Skin exfoliation 25.95 12.21 28 107275 87623 110394373
Abortion missed 25.86 12.21 17 107286 1520 110480476
Ovarian cancer stage III 25.79 12.21 10 107293 286 110481710
Eosinophilia 25.69 12.21 12 107291 57924 110424072
Hypervolaemia 25.67 12.21 8 107295 49452 110432544
Injection site injury 25.66 12.21 15 107288 1089 110480907
Skull fracture 25.62 12.21 19 107284 2061 110479935
Heavy menstrual bleeding 25.57 12.21 52 107251 16313 110465683
Shock 25.52 12.21 10 107293 53578 110428418
Demyelination 25.26 12.21 38 107265 9391 110472605
Rash pruritic 25.17 12.21 35 107268 98034 110383962
Haematuria 25.16 12.21 26 107277 82979 110399017
Cervical dysplasia 25.06 12.21 21 107282 2719 110479277
Raynaud's phenomenon 24.94 12.21 14 107289 941 110481055
Autoimmune thyroiditis 24.93 12.21 31 107272 6403 110475593
Myalgia 24.78 12.21 327 106976 222054 110259942
Rectal cancer 24.71 12.21 24 107279 3765 110478231
Spondylolisthesis 24.66 12.21 24 107279 3774 110478222
Somnolence 24.64 12.21 178 107125 297271 110184725
Haemoptysis 24.41 12.21 20 107283 71334 110410662
Nerve injury 24.30 12.21 40 107263 10673 110471323
Feeling of body temperature change 24.27 12.21 30 107273 6158 110475838
Wound infection 24.19 12.21 35 107268 96430 110385566
Intervertebral disc displacement 24.16 12.21 11 107292 473 110481523
Cephalo-pelvic disproportion 24.15 12.21 8 107295 143 110481853
Bone marrow failure 24.12 12.21 13 107290 57835 110424161
Fear of injection 24 12.21 36 107267 8875 110473121
Urinary tract infection staphylococcal 23.92 12.21 14 107289 1019 110480977
Incision site complication 23.91 12.21 13 107290 821 110481175
Limb mass 23.77 12.21 24 107279 3945 110478051
Impaired healing 23.76 12.21 104 107199 196613 110285383
Bladder dysfunction 23.70 12.21 16 107287 1496 110480500
Oral candidiasis 23.66 12.21 7 107296 44753 110437243
Acute respiratory failure 23.46 12.21 23 107280 75237 110406759
Cholestasis 23.45 12.21 17 107286 64501 110417495
Enterocele 23.32 12.21 6 107297 41 110481955
Vaccination complication 23.32 12.21 13 107290 862 110481134
Product administration error 23.32 12.21 4 107299 37213 110444783
Scoliosis 23.12 12.21 35 107268 8698 110473298
Fibrocystic breast disease 23.04 12.21 12 107291 694 110481302
Gun shot wound 22.96 12.21 14 107289 1098 110480898
Female genital operation 22.78 12.21 5 107298 15 110481981
Atrophy 22.78 12.21 19 107284 2445 110479551
Pregnancy 22.67 12.21 104 107199 50963 110431033
Clavicle fracture 22.58 12.21 27 107276 5357 110476639
Magnetic resonance imaging head abnormal 22.32 12.21 22 107281 3513 110478483
Neoplasm malignant 22.29 12.21 83 107220 37060 110444936
Erectile dysfunction 22.23 12.21 53 107250 18503 110463493
Product prescribing error 22.20 12.21 11 107292 51320 110430676
Fat necrosis 22.17 12.21 13 107290 949 110481047
Lumbar radiculopathy 22.03 12.21 19 107284 2559 110479437
Sinusitis 22.02 12.21 183 107120 296505 110185491
Retinal tear 22.01 12.21 17 107286 1960 110480036
Bladder prolapse 21.98 12.21 15 107288 1427 110480569
Optic nerve disorder 21.98 12.21 16 107287 1687 110480309
Herpes zoster 21.93 12.21 180 107123 108199 110373797
Hypercalcaemia 21.74 12.21 9 107294 46648 110435348
Post procedural infection 21.72 12.21 44 107259 13765 110468231
Uterine disorder 21.63 12.21 18 107285 2308 110479688
Cholecystitis infective 21.54 12.21 22 107281 3665 110478331
Glioblastoma multiforme 21.54 12.21 15 107288 1475 110480521
Benign neoplasm of spinal cord 21.52 12.21 4 107299 3 110481993
JC polyomavirus test positive 21.49 12.21 18 107285 2329 110479667
Musculoskeletal pain 21.36 12.21 98 107205 182925 110299071
Conversion disorder 21.34 12.21 18 107285 2352 110479644
Lipoatrophy 21.34 12.21 11 107292 623 110481373
Urinary bladder suspension 21.08 12.21 7 107296 126 110481870
Precancerous cells present 21.03 12.21 14 107289 1279 110480717
Arthroscopy 21.00 12.21 11 107292 644 110481352
Cardiogenic shock 20.98 12.21 15 107288 57323 110424673
Patella fracture 20.97 12.21 18 107285 2408 110479588
Angioedema 20.75 12.21 40 107263 98460 110383536
Facial paralysis 20.70 12.21 61 107242 24153 110457843
Basal cell carcinoma 20.70 12.21 93 107210 45177 110436819
Hepatic cytolysis 20.68 12.21 14 107289 55039 110426957
Transient ischaemic attack 20.53 12.21 119 107184 63863 110418133
Spinal fusion surgery 20.52 12.21 34 107269 9122 110472874
Colon cancer metastatic 20.50 12.21 18 107285 2483 110479513
Premature labour 20.48 12.21 34 107269 9138 110472858
Incontinence 20.46 12.21 48 107255 16587 110465409
Skin cancer 20.46 12.21 50 107253 17734 110464262
Skin graft 20.45 12.21 13 107290 1098 110480898
Agitation 20.43 12.21 50 107253 113001 110368995
Confusional state 20.32 12.21 326 106977 468354 110013642
Poor venous access 20.23 12.21 61 107242 24461 110457535
Heat stroke 20.16 12.21 16 107287 1919 110480077
Injection site calcification 20.14 12.21 5 107298 29 110481967
Fluid retention 20.12 12.21 38 107265 94269 110387727
Blood pressure diastolic decreased 20.12 12.21 5 107298 35880 110446116
Cardiac valve rupture 20.10 12.21 4 107299 6 110481990
Rectal cancer stage I 20.10 12.21 4 107299 6 110481990
Varicose vein 20.08 12.21 29 107274 6911 110475085
Limb injury 20.06 12.21 81 107222 37555 110444441
Adrenal insufficiency 20.04 12.21 8 107295 42382 110439614
Hepatic function abnormal 19.93 12.21 35 107268 89260 110392736
Viral infection 19.85 12.21 103 107200 53036 110428960
Medical induction of coma 19.73 12.21 7 107296 155 110481841
Schwannoma 19.73 12.21 7 107296 155 110481841
Sarcoidosis 19.69 12.21 40 107263 12539 110469457
Reaction to preservatives 19.67 12.21 8 107295 260 110481736
Porphyria non-acute 19.51 12.21 11 107292 746 110481250
Eye disorder 19.40 12.21 67 107236 28839 110453157
Carotid artery aneurysm 19.39 12.21 9 107294 405 110481591
Urticaria 19.25 12.21 207 107096 318650 110163346
Breast cancer metastatic 19.25 12.21 37 107266 11144 110470852
Bronchopulmonary aspergillosis 19.18 12.21 3 107300 29860 110452136
Retinitis 19.13 12.21 4 107299 32323 110449673
Gastric cyst 18.96 12.21 6 107297 92 110481904
Incision site abscess 18.96 12.21 9 107294 426 110481570
Endometrial adenocarcinoma 18.93 12.21 13 107290 1250 110480746
Injection site thrombosis 18.90 12.21 7 107296 176 110481820
Polyneuropathy 18.87 12.21 4 107299 32008 110449988
Bronchiectasis 18.76 12.21 6 107297 36487 110445509
Injection site fibrosis 18.75 12.21 4 107299 10 110481986
Hip arthroplasty 18.69 12.21 105 107198 55708 110426288
Overweight 18.69 12.21 27 107276 6437 110475559
Nervousness 18.60 12.21 78 107225 36773 110445223
Endometrial cancer stage I 18.54 12.21 7 107296 186 110481810
Invasive lobular breast carcinoma 18.52 12.21 11 107292 823 110481173
Haemophagocytic lymphohistiocytosis 18.48 12.21 4 107299 31555 110450441
Anaesthetic complication 18.37 12.21 20 107283 3586 110478410
Throat irritation 18.33 12.21 15 107288 53537 110428459
Bradycardia 18.30 12.21 83 107220 155434 110326562
Amniotic fluid volume decreased 18.26 12.21 8 107295 314 110481682
Autoimmune disorder 18.21 12.21 22 107281 65461 110416535
Neuralgia 18.13 12.21 94 107209 48384 110433612
Anaphylactic reaction 18.06 12.21 54 107249 114246 110367750
Decreased immune responsiveness 18.05 12.21 33 107270 9573 110472423
Febrile convulsion 18.01 12.21 12 107291 1098 110480898
Female sterilisation 17.97 12.21 8 107295 326 110481670
Complication of delivery 17.97 12.21 6 107297 110 110481886
Deafness unilateral 17.87 12.21 22 107281 4497 110477499
Progressive relapsing multiple sclerosis 17.84 12.21 5 107298 49 110481947
Neurological complication associated with device 17.82 12.21 3 107300 0 110481996
Biopsy bladder 17.82 12.21 3 107300 0 110481996
Alpha-1 anti-trypsin increased 17.82 12.21 3 107300 0 110481996
Disseminated intravascular coagulation 17.63 12.21 9 107294 41277 110440719
Renal tubular necrosis 17.57 12.21 4 107299 30471 110451525
Arterial occlusive disease 17.57 12.21 43 107260 15265 110466731
Animal bite 17.51 12.21 18 107285 3021 110478975
Ovarian adenoma 17.46 12.21 7 107296 219 110481777
Spinal fracture 17.46 12.21 55 107248 22578 110459418
Dry eye 17.45 12.21 17 107286 55776 110426220
Primary biliary cholangitis 17.40 12.21 13 107290 1426 110480570
Intervertebral disc injury 17.34 12.21 7 107296 223 110481773
Uterine leiomyosarcoma 17.33 12.21 4 107299 16 110481980
Lung adenocarcinoma stage I 17.32 12.21 5 107298 55 110481941
Ovarian germ cell teratoma benign 17.32 12.21 5 107298 55 110481941
Oedema peripheral 17.27 12.21 220 107083 328440 110153556
Non-Hodgkin's lymphoma 17.24 12.21 13 107290 1446 110480550
Impaired quality of life 17.19 12.21 4 107299 30013 110451983
Meningitis viral 17.17 12.21 16 107287 2383 110479613
Cast application 17.14 12.21 4 107299 17 110481979
Calculus bladder 17.14 12.21 14 107289 1750 110480246
Escherichia urinary tract infection 17.08 12.21 44 107259 16118 110465878
Onychomycosis 17.06 12.21 8 107295 38523 110443473
Laryngitis 17.01 12.21 10 107293 42401 110439595
Cervical incompetence 17.01 12.21 9 107294 538 110481458
Knee operation 16.99 12.21 27 107276 6995 110475001
Serum serotonin decreased 16.95 12.21 4 107299 18 110481978
Epistaxis 16.93 12.21 67 107236 130305 110351691
Cerebral thrombosis 16.90 12.21 16 107287 2432 110479564
Hyperglycaemia 16.69 12.21 36 107267 85054 110396942
Hand fracture 16.67 12.21 29 107274 8093 110473903
Orthostatic hypotension 16.64 12.21 24 107279 66225 110415771
Complication associated with device 16.62 12.21 50 107253 20023 110461973
Non-small cell lung cancer stage I 16.61 12.21 4 107299 20 110481976
Carpal tunnel syndrome 16.58 12.21 54 107249 22556 110459440
Rhinorrhoea 16.58 12.21 48 107255 102618 110379378
Rash erythematous 16.57 12.21 34 107269 81798 110400198
Hyperaesthesia 16.51 12.21 41 107262 14686 110467310
Hepatic steatosis 16.44 12.21 92 107211 48739 110433257
Condition aggravated 16.42 12.21 566 106737 734270 109747726
Spinal cord disorder 16.39 12.21 15 107288 2183 110479813
Staphylococcal abscess 16.39 12.21 12 107291 1277 110480719
Anger 16.36 12.21 48 107255 18959 110463037
Infection 16.34 12.21 250 107053 361950 110120046
Medical device removal 16.32 12.21 10 107293 791 110481205
Neurofibroma 16.29 12.21 4 107299 22 110481974
Impaired self-care 16.27 12.21 16 107287 2548 110479448
Stevens-Johnson syndrome 16.22 12.21 13 107290 46888 110435108
Tachypnoea 16.21 12.21 9 107294 39386 110442610
Ventricular fibrillation 16.21 12.21 10 107293 41303 110440693
Cystocele 16.17 12.21 11 107292 1041 110480955
Umbilical cord around neck 16.14 12.21 4 107299 23 110481973
Progressive multifocal leukoencephalopathy 16.02 12.21 57 107246 24899 110457097
Thyroid function test abnormal 15.99 12.21 18 107285 3349 110478647
Urinary retention postoperative 15.94 12.21 7 107296 276 110481720
Ventricular tachycardia 15.92 12.21 15 107288 49994 110432002
Bipolar I disorder 15.91 12.21 15 107288 2268 110479728
Lung cancer metastatic 15.90 12.21 20 107283 4178 110477818
Hepatotoxicity 15.90 12.21 23 107280 63377 110418619
Cervix carcinoma stage 0 15.85 12.21 7 107296 280 110481716
Refusal of treatment by patient 15.83 12.21 31 107272 9463 110472533
Eye pruritus 15.80 12.21 6 107297 32769 110449227
Lhermitte's sign 15.74 12.21 3 107300 3 110481993
Ovarian neoplasm 15.74 12.21 9 107294 627 110481369
Live birth 15.72 12.21 27 107276 69457 110412539
Pyelonephritis 15.64 12.21 57 107246 25193 110456803
Uterine haemorrhage 15.44 12.21 18 107285 3476 110478520
Thrombotic thrombocytopenic purpura 15.39 12.21 26 107277 7085 110474911
Reproductive tract disorder 15.38 12.21 5 107298 84 110481912
Urinary retention 15.34 12.21 118 107185 69565 110412431
Breath sounds abnormal 15.33 12.21 3 107300 25401 110456595
Superficial vein prominence 15.33 12.21 5 107298 85 110481911
Aspartate aminotransferase increased 15.32 12.21 229 107074 159707 110322289
B-cell lymphoma stage I 15.28 12.21 3 107300 4 110481992
Foetal heart rate abnormal 15.24 12.21 9 107294 666 110481330
Thyroid cyst 15.18 12.21 8 107295 474 110481522
Injection site plaque 15.14 12.21 6 107297 182 110481814
Drug tolerance decreased 15.13 12.21 4 107299 27536 110454460
Retinopathy 15.05 12.21 20 107283 4409 110477587
Inappropriate antidiuretic hormone secretion 15.03 12.21 7 107296 33844 110448152
Neutralising antibodies 15.00 12.21 4 107299 32 110481964
Cystitis interstitial 14.96 12.21 12 107291 1462 110480534
Liposarcoma 14.95 12.21 7 107296 321 110481675
Arthritis 14.92 12.21 237 107066 167349 110314647
Leukopenia 14.90 12.21 84 107219 148707 110333289
Incoherent 14.81 12.21 28 107275 8330 110473666
Suture rupture 14.78 12.21 9 107294 704 110481292
Rales 14.77 12.21 3 107300 24736 110457260
Ocular hyperaemia 14.74 12.21 10 107293 39276 110442720
Gamma-glutamyltransferase increased 14.73 12.21 106 107197 61203 110420793
Retinal detachment 14.72 12.21 33 107270 11067 110470929
Viral pericarditis 14.71 12.21 5 107298 97 110481899
Withdrawal syndrome 14.71 12.21 6 107297 31374 110450622
Uterine mass 14.68 12.21 7 107296 335 110481661
Fasciitis 14.66 12.21 10 107293 951 110481045
Optic atrophy 14.65 12.21 15 107288 2506 110479490
Uterine cyst 14.64 12.21 7 107296 337 110481659
Uterine prolapse 14.56 12.21 10 107293 962 110481034
Focal segmental glomerulosclerosis 14.52 12.21 19 107284 4126 110477870
Restlessness 14.51 12.21 20 107283 56239 110425757
Hypoalbuminaemia 14.48 12.21 5 107298 28969 110453027
Insomnia 14.47 12.21 455 106848 360135 110121861
Appendix disorder 14.43 12.21 13 107290 1855 110480141
Ovarian cyst ruptured 14.38 12.21 11 107292 1250 110480746
Lung carcinoma cell type unspecified stage IV 14.35 12.21 14 107289 2208 110479788
Umbilical hernia 14.32 12.21 25 107278 6997 110474999
Arterial therapeutic procedure 14.29 12.21 4 107299 39 110481957
Benign renal neoplasm 14.29 12.21 4 107299 39 110481957
Relapsing multiple sclerosis 14.26 12.21 6 107297 213 110481783
Obesity 14.25 12.21 59 107244 113292 110368704
Lung neoplasm 14.24 12.21 27 107276 8049 110473947
Pneumonia 14.19 12.21 1010 106293 875704 109606292
Narcolepsy 14.17 12.21 12 107291 1576 110480420
Postoperative thrombosis 14.15 12.21 6 107297 217 110481779
Intestinal cyst 14.07 12.21 6 107297 220 110481776
Abdominal hernia 14.04 12.21 24 107279 6605 110475391
Colon cancer stage I 14.00 12.21 5 107298 113 110481883
Lyme disease 13.92 12.21 19 107284 4297 110477699
Muscle disorder 13.92 12.21 24 107279 6648 110475348
Placenta praevia 13.88 12.21 9 107294 786 110481210
Device failure 13.84 12.21 25 107278 7182 110474814
Arthritis infective 13.83 12.21 31 107272 10398 110471598
Right ventricular failure 13.83 12.21 4 107299 25950 110456046
Hypotonia 13.78 12.21 40 107263 15705 110466291
Product dose omission in error 13.73 12.21 3 107300 23509 110458487
Full blood count decreased 13.70 12.21 7 107296 32092 110449904
Deep vein thrombosis 13.67 12.21 201 107102 139686 110342310
Cystitis pseudomonal 13.67 12.21 3 107300 9 110481987
Ureterolithiasis 13.63 12.21 19 107284 4383 110477613
Blood calcium decreased 13.62 12.21 9 107294 35836 110446160
Infected skin ulcer 13.62 12.21 18 107285 3949 110478047
Blood pressure fluctuation 13.59 12.21 33 107270 74791 110407205
Spinal laminectomy 13.55 12.21 9 107294 819 110481177
Immune system disorder 13.50 12.21 36 107267 13465 110468531
Muscle contractions involuntary 13.49 12.21 19 107284 4425 110477571
Aneurysm 13.48 12.21 19 107284 4427 110477569
Myelitis transverse 13.44 12.21 14 107289 2387 110479609
Oral pain 13.43 12.21 10 107293 37434 110444562
Gastroenteritis viral 13.42 12.21 63 107240 31163 110450833
Altered state of consciousness 13.40 12.21 22 107281 57604 110424392
Intervertebral disc compression 13.39 12.21 11 107292 1386 110480610
Motor dysfunction 13.38 12.21 53 107250 24353 110457643
Toxic skin eruption 13.32 12.21 5 107298 27510 110454486
Clinically isolated syndrome 13.32 12.21 4 107299 51 110481945
Therapeutic response shortened 13.32 12.21 6 107297 29577 110452419
Nephropathy toxic 13.30 12.21 5 107298 27473 110454523
Central nervous system infection 13.27 12.21 12 107291 1720 110480276
Breast cellulitis 13.20 12.21 7 107296 420 110481576
Partial seizures 13.15 12.21 32 107271 11317 110470679
Splenectomy 13.14 12.21 9 107294 861 110481135
Injection site pruritus 13.12 12.21 90 107213 51168 110430828
Paraganglion neoplasm 13.11 12.21 4 107299 54 110481942
Anembryonic gestation 13.10 12.21 7 107296 427 110481569
Intracranial hypotension 13.09 12.21 8 107295 630 110481366
Complication of pregnancy 13.08 12.21 7 107296 428 110481568
Arnold-Chiari malformation 13.07 12.21 6 107297 263 110481733
Hepatitis C 13.05 12.21 34 107269 12539 110469457
Abdominal operation 13.01 12.21 9 107294 876 110481120
Neurilemmoma benign 13 12.21 3 107300 12 110481984
Limb traumatic amputation 12.98 12.21 4 107299 56 110481940
Chondropathy 12.97 12.21 15 107288 2872 110479124
Skin haemorrhage 12.91 12.21 4 107299 24823 110457173
Myelopathy 12.89 12.21 21 107282 5555 110476441
Malignant mesenteric neoplasm 12.85 12.21 4 107299 58 110481938
Abdominal adhesions 12.85 12.21 18 107285 4172 110477824
Heat exhaustion 12.83 12.21 7 107296 445 110481551
Haemorrhagic ovarian cyst 12.81 12.21 8 107295 655 110481341
Anti-interferon antibody positive 12.81 12.21 3 107300 13 110481983
Procedural site reaction 12.80 12.21 7 107296 447 110481549
Blood urea increased 12.76 12.21 21 107282 54936 110427060
Mastitis 12.70 12.21 14 107289 2544 110479452
Lobular breast carcinoma in situ 12.66 12.21 4 107299 61 110481935
Nodule 12.66 12.21 8 107295 32623 110449373
Maternal exposure timing unspecified 12.65 12.21 47 107256 20966 110461030
Bacterial food poisoning 12.63 12.21 3 107300 14 110481982
Chronic leukaemia 12.63 12.21 3 107300 14 110481982
Tubular breast carcinoma 12.63 12.21 3 107300 14 110481982
Skin fissures 12.61 12.21 4 107299 24454 110457542
Hemianaesthesia 12.56 12.21 7 107296 464 110481532
Purpura 12.56 12.21 4 107299 24384 110457612
Cardiomyopathy 12.53 12.21 65 107238 33460 110448536
Injection site hypoaesthesia 12.51 12.21 8 107295 683 110481313
Alanine aminotransferase increased 12.48 12.21 249 107054 183524 110298472
Otolithiasis 12.46 12.21 3 107300 15 110481981
Vitamin D deficiency 12.45 12.21 43 107260 18509 110463487
Brain neoplasm malignant 12.43 12.21 12 107291 1868 110480128
Benign neoplasm of bladder 12.32 12.21 4 107299 67 110481929
Tumefactive multiple sclerosis 12.31 12.21 5 107298 162 110481834
Burns third degree 12.26 12.21 7 107296 486 110481510
Migraine with aura 12.23 12.21 16 107287 3476 110478520

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC L03AB07 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
IMMUNOSTIMULANTS
IMMUNOSTIMULANTS
Interferons
FDA CS M0025715 Interferon-beta
MeSH PA D000276 Adjuvants, Immunologic
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000970 Antineoplastic Agents
MeSH PA D000998 Antiviral Agents
MeSH PA D007155 Immunologic Factors
FDA EPC N0000191625 Interferon beta
CHEBI has role CHEBI:22587 antiviral agent
CHEBI has role CHEBI:33281 antimicrobial agent
CHEBI has role CHEBI:35610 antineoplastic agent
CHEBI has role CHEBI:35705 immunosuppressive agent
CHEBI has role CHEBI:65023 anti-asthmatic agent
CHEBI has role CHEBI:67079 anti-inflammatory agent

Related Drugs by ATC class:

L03AB Interferons 6 drugs
interferon alfa-2binterferon beta-1bpeginterferon alfa-2apeginterferon alfa-2bpeginterferon beta-1aropeginterferon alfa-2b

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Relapsing remitting multiple sclerosis indication 426373005 DOID:2378




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Interferon alpha/beta receptor Membrane receptor AGONIST DRUG LABEL DRUG LABEL

External reference:

IDSource
XRO4566Q4R UNII
4024025 VANDF
C0254119 UMLSCUI
CHEBI:749518 CHEBI
CHEMBL1201562 ChEMBL_ID
D04554 KEGG_DRUG
DB00060 DRUGBANK_ID
CHEMBL2108510 ChEMBL_ID
D000068556 MESH_DESCRIPTOR_UI
153326 RXNORM
4895 MMSL
6144 MMSL
d04011 MMSL
005910 NDDF
108749003 SNOMEDCT_US
386902004 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
REBIF HUMAN PRESCRIPTION DRUG LABEL 1 44087-0022 INJECTION, SOLUTION 22 ug SUBCUTANEOUS BLA 30 sections
REBIF HUMAN PRESCRIPTION DRUG LABEL 1 44087-0044 INJECTION, SOLUTION 44 ug SUBCUTANEOUS BLA 30 sections
REBIF REBIDOSE HUMAN PRESCRIPTION DRUG LABEL 1 44087-3322 INJECTION, SOLUTION 22 ug SUBCUTANEOUS BLA 30 sections
REBIF REBIDOSE HUMAN PRESCRIPTION DRUG LABEL 1 44087-3344 INJECTION, SOLUTION 44 ug SUBCUTANEOUS BLA 30 sections
Avonex HUMAN PRESCRIPTION DRUG LABEL 1 59627-002 INJECTION, SOLUTION 30 ug INTRAMUSCULAR BLA 28 sections
Avonex Pen HUMAN PRESCRIPTION DRUG LABEL 1 59627-003 INJECTION, SOLUTION 30 ug INTRAMUSCULAR BLA 28 sections