interferon beta-1a 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
5139 145258-61-3

Description:

MoleculeDescription

Synonyms:

  • interferon beta-1a
  • avonex
An interferon beta-1 subtype that has a methionine at position 1, a cysteine at position 17, and is glycosylated at position 80. It functions as an ANTI-VIRAL AGENT and IMMUNOMODULATOR and is used to manage the symptoms of RELAPSING-REMITTING MULTIPLE SCLEROSIS. A possible role for IFNs in prophylaxis or early treatment of COVID-19 has been suggested to compensate for possibly insufficient endogenous IFN production. However, the efficacy and safety of IFNs for treatment or prevention of COVID-19 were not established.
  • Molecular weight:
  • Formula:
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA:
  • ALOGS:
  • ROTB: None

Drug dosage:

DoseUnitRoute
4.30 mcg P

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
May 17, 1996 FDA BIOGEN

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Multiple sclerosis relapse 8453.14 11.46 3347 117893 39617 50444267
Influenza like illness 4688.34 11.46 2424 118816 55035 50428849
General symptom 880.93 11.46 299 120941 2164 50481720
Fall 825.34 11.46 2196 119044 332736 50151148
Injection site erythema 799.78 11.46 941 120299 73995 50409889
Optic neuritis 772.80 11.46 362 120878 6528 50477356
Off label use 739.94 11.46 125 121115 474301 50009583
Gait disturbance 720.32 11.46 1289 119951 148716 50335168
Central nervous system lesion 702.21 11.46 376 120864 9113 50474771
Breast cancer 692.16 11.46 671 120569 42219 50441665
Injection site pain 669.95 11.46 1057 120183 109967 50373917
Memory impairment 567.35 11.46 818 120422 78542 50405342
Depression 562.23 11.46 1230 120010 164193 50319691
Balance disorder 497.76 11.46 723 120517 69867 50414017
Hypoaesthesia 488.76 11.46 995 120245 126262 50357622
Urinary tract infection 415.36 11.46 1329 119911 222691 50261193
Seizure 406.36 11.46 882 120358 116992 50366892
Diarrhoea 396.04 11.46 499 120741 587977 49895907
Injection site bruising 384.03 11.46 457 120783 36311 50447573
Toxicity to various agents 370.83 11.46 39 121201 212460 50271424
Loss of control of legs 358.17 11.46 130 121110 1171 50482713
Muscular weakness 348.19 11.46 729 120511 94284 50389600
Magnetic resonance imaging abnormal 330.29 11.46 151 121089 2567 50481317
Rash 325.15 11.46 342 120898 437129 50046755
Contraindicated product administered 315.25 11.46 9 121231 148949 50334935
Secondary progressive multiple sclerosis 313.44 11.46 117 121123 1149 50482735
Gait inability 309.83 11.46 412 120828 36615 50447269
Product use issue 305.86 11.46 12 121228 149463 50334421
Injection site haematoma 290.31 11.46 181 121059 5879 50478005
Intervertebral disc protrusion 284.54 11.46 295 120945 20098 50463786
Dyspnoea 283.61 11.46 553 120687 547055 49936829
Drug ineffective 278.94 11.46 1020 120220 818313 49665571
Synovitis 275.88 11.46 4 121236 123861 50360023
Stress 270.08 11.46 472 120768 53321 50430563
Joint swelling 268.52 11.46 126 121114 245160 50238724
Cognitive disorder 261.40 11.46 417 120823 43706 50440178
Infusion related reaction 258.39 11.46 47 121193 169510 50314374
Rheumatoid arthritis 258.15 11.46 82 121158 202468 50281416
Drug interaction 254.08 11.46 81 121159 199540 50284344
Injection site reaction 252.46 11.46 440 120800 49592 50434292
Product use in unapproved indication 248.78 11.46 6 121234 115813 50368071
Breast cancer female 239.01 11.46 168 121072 6694 50477190
Uterine leiomyoma 237.91 11.46 177 121063 7714 50476170
Injection site haemorrhage 222.29 11.46 265 120975 21081 50462803
Glossodynia 218.43 11.46 15 121225 115554 50368330
Completed suicide 213.34 11.46 31 121209 131858 50352026
Injection site scar 212.15 11.46 79 121161 770 50483114
Needle fatigue 207.88 11.46 47 121193 40 50483844
Hysterectomy 207.16 11.46 163 121077 7727 50476157
Decubitus ulcer 206.14 11.46 175 121065 9243 50474641
Abortion spontaneous 205.07 11.46 363 120877 41409 50442475
Abdominal discomfort 204.21 11.46 154 121086 231487 50252397
Neutropenia 203.06 11.46 52 121188 147913 50335971
Acute kidney injury 198.00 11.46 154 121086 227904 50255980
Chills 197.55 11.46 594 120646 96093 50387791
Ankle fracture 195.56 11.46 214 121026 15508 50468376
Injection site necrosis 193.51 11.46 82 121158 1151 50482733
Trigeminal neuralgia 193.47 11.46 110 121130 3005 50480879
Nausea 193.32 11.46 953 120287 704445 49779439
Febrile neutropenia 189.57 11.46 11 121229 97656 50386228
Peripheral swelling 189.21 11.46 131 121109 205805 50278079
Muscle spasticity 181.68 11.46 215 121025 16969 50466915
Drug hypersensitivity 178.57 11.46 203 121037 250807 50233077
Road traffic accident 172.28 11.46 250 120990 24102 50459782
Peroneal nerve palsy 170.80 11.46 114 121126 4169 50479715
Injection site infection 169.40 11.46 82 121158 1594 50482290
Abdominal pain 166.98 11.46 192 121048 236036 50247848
Musculoskeletal disorder 165.41 11.46 206 121034 17143 50466741
Coronary artery occlusion 161.31 11.46 138 121102 7365 50476519
Injection site abscess 158.79 11.46 68 121172 981 50482903
Urinary incontinence 152.68 11.46 256 120984 27952 50455932
Stomatitis 152.37 11.46 29 121211 101315 50382569
Bladder disorder 150.60 11.46 133 121107 7410 50476474
Myocardial infarction 150.00 11.46 512 120728 88515 50395369
Arthralgia 144.60 11.46 552 120688 438150 50045734
Hypotension 144.19 11.46 213 121027 235256 50248628
Neuromyelitis optica spectrum disorder 143.30 11.46 59 121181 767 50483117
Cough 143.15 11.46 223 121017 241041 50242843
Coordination abnormal 141.71 11.46 156 121084 11378 50472506
Progressive multiple sclerosis 141.49 11.46 57 121183 698 50483186
Maternal exposure timing unspecified 141.10 11.46 95 121145 3525 50480359
Malignant neoplasm progression 140.89 11.46 5 121235 68119 50415765
Therapeutic product effect decreased 138.10 11.46 77 121163 135973 50347911
Systemic lupus erythematosus 136.49 11.46 84 121156 140538 50343346
Injection site cellulitis 135.64 11.46 63 121177 1112 50482772
Injection site mass 135.00 11.46 177 121063 15503 50468381
Abortion 134.59 11.46 76 121164 2048 50481836
Cerebrovascular accident 134.45 11.46 515 120725 94165 50389719
Injection site atrophy 132.74 11.46 49 121191 465 50483419
Diabetes mellitus 132.67 11.46 334 120906 48699 50435185
Therapeutic product effect incomplete 131.74 11.46 29 121211 91486 50392398
Thyroid cancer 131.26 11.46 96 121144 4073 50479811
Pruritus 129.09 11.46 307 120933 283261 50200623
Mobility decreased 127.04 11.46 451 120789 79497 50404387
Alopecia 126.72 11.46 247 120993 244800 50239084
Muscle spasms 124.61 11.46 613 120627 124940 50358944
Pericarditis 123.77 11.46 20 121220 78669 50405215
Swelling 120.71 11.46 184 121056 200688 50283196
Hyponatraemia 118.72 11.46 41 121199 96098 50387786
Lower respiratory tract infection 118.60 11.46 40 121200 95161 50388723
Caesarean section 117.14 11.46 165 121075 15474 50468410
Injection site induration 114.47 11.46 120 121120 8277 50475607
Head injury 114.34 11.46 206 121034 23814 50460070
Adverse drug reaction 114.34 11.46 341 120899 54881 50429003
Pancytopenia 114.33 11.46 30 121210 84000 50399884
C-reactive protein increased 113.77 11.46 13 121227 66461 50417423
Post procedural complication 112.60 11.46 159 121081 14945 50468939
Adverse reaction 112.25 11.46 120 121120 8466 50475418
Intentional product use issue 109.45 11.46 25 121215 76893 50406991
Lower limb fracture 106.25 11.46 150 121090 14096 50469788
Breast cancer in situ 103.86 11.46 56 121184 1375 50482509
Blood creatinine increased 102.08 11.46 28 121212 76132 50407752
Neurogenic bladder 101.94 11.46 71 121169 2786 50481098
Hyperkalaemia 97.82 11.46 4 121236 48085 50435799
Paraesthesia 97.31 11.46 555 120685 119688 50364196
Electrocardiogram QT prolonged 97.23 11.46 7 121233 51879 50432005
Decreased appetite 96.65 11.46 211 121029 200712 50283172
Relapsing-remitting multiple sclerosis 95.54 11.46 38 121202 449 50483435
Hypokalaemia 94.90 11.46 46 121194 87946 50395938
Breast cancer stage I 94.21 11.46 59 121181 1931 50481953
Visual impairment 94.13 11.46 368 120872 67907 50415977
Blindness unilateral 94.07 11.46 87 121153 5148 50478736
Tremor 94.06 11.46 532 120708 114371 50369513
Multiple sclerosis 94.05 11.46 173 121067 20320 50463564
Migraine 93.64 11.46 393 120847 74887 50408997
Malignant melanoma 93.12 11.46 118 121122 9990 50473894
Nephrolithiasis 92.46 11.46 235 121005 34458 50449426
Drug abuse 92.36 11.46 16 121224 59830 50424054
Amnesia 91.33 11.46 265 120975 41995 50441889
Phobia 90.74 11.46 33 121207 299 50483585
Hip fracture 89.11 11.46 194 121046 25737 50458147
Intracranial aneurysm 88.71 11.46 69 121171 3215 50480669
Drug delivery device placement 88.63 11.46 25 121215 87 50483797
Cystitis 88.31 11.46 271 120969 44293 50439591
Breast cancer stage II 88.04 11.46 53 121187 1614 50482270
Hemiparesis 87.95 11.46 166 121074 19882 50464002
Anaemia 86.66 11.46 312 120928 252144 50231740
Vomiting 86.63 11.46 698 120542 460060 50023824
Helicobacter infection 84.35 11.46 10 121230 49692 50434192
Therapeutic response decreased 84.01 11.46 8 121232 47223 50436661
Haemoglobin decreased 83.86 11.46 109 121131 127107 50356777
Upper limb fracture 81.84 11.46 141 121099 15732 50468152
Ovarian cancer 80.05 11.46 79 121161 5070 50478814
Injection site discolouration 79.97 11.46 91 121149 6883 50477001
Thrombocytopenia 78.53 11.46 115 121125 127558 50356326
Procedural anxiety 78.10 11.46 36 121204 624 50483260
Asthenia 77.46 11.46 1132 120108 317910 50165974
Loss of personal independence in daily activities 76.48 11.46 36 121204 70014 50413870
Sensory disturbance 75.85 11.46 116 121124 11713 50472171
Blister 74.88 11.46 57 121183 85361 50398523
Mucosal inflammation 73.56 11.46 6 121234 40136 50443748
Wound 73.55 11.46 87 121153 105707 50378177
Oxygen saturation decreased 73.51 11.46 42 121198 73206 50410678
Pleural effusion 73.15 11.46 53 121187 81401 50402483
Drug specific antibody present 72.51 11.46 62 121178 3306 50480578
Interstitial lung disease 72.29 11.46 19 121221 53157 50430727
Oedema 72.22 11.46 39 121201 70142 50413742
Psoriatic arthropathy 71.65 11.46 13 121227 47019 50436865
Psoriasis 71.51 11.46 38 121202 68962 50414922
Folliculitis 71.50 11.46 6 121234 39219 50444665
Dyspnoea exertional 70.23 11.46 18 121222 51215 50432669
Staphylococcal infection 70.01 11.46 216 121024 35400 50448484
Kidney infection 69.90 11.46 145 121095 18601 50465283
Cholelithiasis 69.79 11.46 225 121015 37748 50446136
Neutralising antibodies positive 69.18 11.46 25 121215 222 50483662
Tachycardia 68.33 11.46 83 121157 99680 50384204
Dysgraphia 67.55 11.46 54 121186 2619 50481265
Appendicitis 66.92 11.46 81 121159 6543 50477341
Injection site nodule 66.76 11.46 59 121181 3289 50480595
Muscle injury 66.76 11.46 6 121234 37105 50446779
Lung neoplasm malignant 66.42 11.46 127 121113 15357 50468527
Dysstasia 65.47 11.46 137 121103 17682 50466202
Intentional overdose 65.40 11.46 34 121206 62470 50421414
Wheezing 64.55 11.46 34 121206 62013 50421871
Metabolic acidosis 63.03 11.46 9 121231 38816 50445068
Meningioma benign 62.66 11.46 25 121215 298 50483586
Hospitalisation 62.59 11.46 43 121197 67894 50415990
Arthropathy 62.57 11.46 183 121057 157723 50326161
Hypoglycaemia 62.51 11.46 25 121215 53556 50430328
Injection site ulcer 62.28 11.46 29 121211 515 50483369
Mental impairment 62.11 11.46 107 121133 11937 50471947
Blindness 61.39 11.46 131 121109 17138 50466746
Lack of injection site rotation 61.15 11.46 24 121216 273 50483611
Lactic acidosis 61.08 11.46 5 121235 33350 50450534
Productive cough 60.80 11.46 25 121215 52669 50431215
Thrombosis 60.69 11.46 280 120960 55553 50428331
Neuropathy peripheral 60.62 11.46 86 121154 96671 50387213
Multiple organ dysfunction syndrome 59.53 11.46 23 121217 50314 50433570
Gastric bypass 58.84 11.46 39 121201 1409 50482475
Endometriosis 58.72 11.46 60 121180 4015 50479869
Temperature intolerance 58.63 11.46 81 121159 7458 50476426
Speech disorder 58.55 11.46 203 121037 35345 50448539
Injury associated with device 58.34 11.46 53 121187 3064 50480820
Somnolence 58.27 11.46 184 121056 154801 50329083
Neutrophil count decreased 57.89 11.46 19 121221 46007 50437877
Ligament rupture 57.75 11.46 49 121191 2585 50481299
Bradycardia 57.74 11.46 42 121198 64384 50419500
Anxiety 57.67 11.46 665 120575 176941 50306943
Epilepsy 57.36 11.46 146 121094 21421 50462463
Diplopia 57.18 11.46 136 121104 19124 50464760
Generalised tonic-clonic seizure 56.85 11.46 165 121075 26145 50457739
Hypertension 56.24 11.46 762 120478 210441 50273443
Invasive ductal breast carcinoma 55.94 11.46 70 121170 5851 50478033
Intervertebral disc disorder 55.35 11.46 60 121180 4300 50479584
Cervix carcinoma 55.01 11.46 47 121193 2503 50481381
General physical health deterioration 54.32 11.46 168 121072 142266 50341618
International normalised ratio increased 53.95 11.46 18 121222 43134 50440750
Procedural pain 53.94 11.46 109 121131 13723 50470161
Scar 53.26 11.46 99 121141 11719 50472165
Influenza 53.06 11.46 382 120858 89156 50394728
Primary progressive multiple sclerosis 52.61 11.46 16 121224 77 50483807
Appendicitis perforated 52.08 11.46 37 121203 1499 50482385
Suicidal ideation 51.76 11.46 266 120974 55119 50428765
Renal impairment 51.75 11.46 63 121177 75598 50408286
Hypoxia 51.74 11.46 29 121211 51094 50432790
Agraphia 51.26 11.46 13 121227 26 50483858
Overdose 51.04 11.46 101 121139 99626 50384258
Intraductal proliferative breast lesion 50.97 11.46 45 121195 2505 50481379
Cervical spinal stenosis 50.70 11.46 40 121200 1903 50481981
Concussion 50.60 11.46 76 121164 7552 50476332
Basedow's disease 50.39 11.46 21 121219 282 50483602
Cardiac failure 50.25 11.46 65 121175 75975 50407909
Feeling abnormal 50.14 11.46 490 120750 125002 50358882
Autoimmune hepatitis 50.00 11.46 75 121165 7444 50476440
Platelet count decreased 49.86 11.46 104 121136 100622 50383262
Constipation 49.82 11.46 252 120988 185456 50298428
Blood pressure systolic increased 49.47 11.46 12 121228 35437 50448447
Gastrointestinal haemorrhage 49.15 11.46 62 121178 73259 50410625
Lumbar spinal stenosis 48.99 11.46 55 121185 4099 50479785
Discomfort 48.68 11.46 118 121122 108262 50375622
Postoperative wound infection 48.65 11.46 79 121161 8396 50475488
Spinal stenosis 48.41 11.46 103 121137 13447 50470437
Treatment failure 47.89 11.46 169 121071 137468 50346416
Retinal exudates 47.37 11.46 26 121214 662 50483222
Aphasia 47.17 11.46 163 121077 28331 50455553
Mouth ulceration 46.67 11.46 6 121234 28018 50455866
Intentional product misuse 46.59 11.46 27 121213 46707 50437177
Hypocalcaemia 46.49 11.46 5 121235 26811 50457073
Meningioma 46.49 11.46 49 121191 3400 50480484
Sinusitis 46.00 11.46 231 121009 170327 50313557
Cardio-respiratory arrest 45.91 11.46 37 121203 53855 50430029
Cholecystectomy 45.82 11.46 81 121159 9222 50474662
Injection site scab 45.71 11.46 21 121219 361 50483523
Nasal congestion 44.93 11.46 34 121206 51086 50432798
Uterine cancer 44.06 11.46 50 121190 3770 50480114
Product quality issue 43.94 11.46 10 121230 30848 50453036
Depressed level of consciousness 43.84 11.46 36 121204 51917 50431967
Erythema 43.78 11.46 191 121049 146223 50337661
Sedation 43.43 11.46 10 121230 30600 50453284
Malaise 42.79 11.46 1079 120161 334453 50149431
Frustration tolerance decreased 42.69 11.46 60 121180 5614 50478270
Clostridial infection 42.29 11.46 50 121190 3940 50479944
Sarcoidosis 42.20 11.46 56 121184 4961 50478923
Neoplasm malignant 42.20 11.46 139 121101 23576 50460308
Bipolar disorder 41.55 11.46 65 121175 6692 50477192
Paralysis 40.84 11.46 74 121166 8590 50475294
Septic shock 40.82 11.46 46 121194 57129 50426755
Colon cancer 40.67 11.46 74 121166 8617 50475267
Ovarian cyst 40.65 11.46 98 121142 13898 50469986
Thyroid disorder 40.35 11.46 92 121148 12585 50471299
Pulmonary thrombosis 40.21 11.46 68 121172 7473 50476411
Intervertebral disc degeneration 39.90 11.46 95 121145 13366 50470518
Ruptured cerebral aneurysm 39.49 11.46 20 121220 430 50483454
Band sensation 39.21 11.46 23 121217 667 50483217
Focal dyscognitive seizures 38.96 11.46 40 121200 2692 50481192
Respiratory failure 38.83 11.46 102 121138 91079 50392805
Depressed mood 38.74 11.46 173 121067 33850 50450034
Medication error 38.72 11.46 19 121221 36085 50447799
Therapy non-responder 38.71 11.46 39 121201 50983 50432901
Injection site calcification 38.48 11.46 10 121230 23 50483861
Paraparesis 38.44 11.46 35 121205 2029 50481855
Accidental exposure to product 38.24 11.46 5 121235 23052 50460832
Micturition urgency 38.21 11.46 70 121170 8194 50475690
Bladder cancer 37.40 11.46 43 121197 3289 50480595
Motor dysfunction 37.10 11.46 68 121172 7963 50475921
Burning sensation 36.86 11.46 210 121030 45236 50438648
Autoimmune thyroiditis 36.21 11.46 42 121198 3243 50480641
Weight increased 35.91 11.46 310 120930 201581 50282303
Oral pain 35.87 11.46 8 121232 25025 50458859
Abdominal pain upper 35.79 11.46 229 121011 159080 50324804
Pneumonitis 35.70 11.46 13 121227 29497 50454387
Dyspepsia 35.42 11.46 78 121162 74019 50409865
Feeling cold 35.22 11.46 115 121125 19416 50464468
Serotonin syndrome 35.21 11.46 8 121232 24705 50459179
Injection site injury 35.18 11.46 20 121220 546 50483338
Paraplegia 35.12 11.46 36 121204 2418 50481466
Muscle atrophy 35.06 11.46 57 121183 6064 50477820
Bladder dysfunction 34.91 11.46 22 121218 728 50483156
Hypervolaemia 34.87 11.46 9 121231 25490 50458394
Blood creatine phosphokinase increased 34.75 11.46 10 121230 26357 50457527
Surgery 34.70 11.46 154 121086 30051 50453833
Neutralising antibodies 34.57 11.46 10 121230 39 50483845
Haematochezia 34.45 11.46 27 121213 39855 50444029
Brain neoplasm benign 34.35 11.46 14 121226 177 50483707
Rhabdomyolysis 34.24 11.46 26 121214 39001 50444883
Nerve compression 34.24 11.46 63 121177 7399 50476485
Ascites 33.96 11.46 22 121218 35839 50448045
Condition aggravated 33.96 11.46 504 120736 296554 50187330
Red blood cell sedimentation rate increased 33.86 11.46 14 121226 29402 50454482
Reaction to preservatives 33.53 11.46 14 121226 189 50483695
Incorrect dose administered 33.43 11.46 40 121200 48374 50435510
Papillary thyroid cancer 33.36 11.46 32 121208 1983 50481901
Procedural complication 33.35 11.46 49 121191 4774 50479110
Myelitis transverse 33.19 11.46 24 121216 1000 50482884
Tibia fracture 33.19 11.46 47 121193 4428 50479456
Ectopic pregnancy 33.05 11.46 34 121206 2293 50481591
Abdominal distension 33.02 11.46 79 121161 72824 50411060
Oedema peripheral 33.01 11.46 232 121008 157729 50326155
Rash pruritic 32.54 11.46 40 121200 47806 50436078
Appendicectomy 32.53 11.46 35 121205 2487 50481397
Meniscus injury 32.51 11.46 56 121184 6246 50477638
Drug level increased 32.39 11.46 4 121236 19264 50464620
Inflammation 32.36 11.46 54 121186 56858 50427026
Full blood count decreased 32.30 11.46 7 121233 22339 50461545
Bone marrow failure 32.04 11.46 13 121227 27611 50456273
Agitation 31.91 11.46 49 121191 53335 50430549
Injection site fibrosis 31.88 11.46 8 121232 15 50483869
Drug resistance 31.78 11.46 4 121236 18985 50464899
Benign breast neoplasm 31.50 11.46 24 121216 1084 50482800
Vision blurred 31.35 11.46 307 120933 78340 50405544
Optic nerve disorder 31.28 11.46 20 121220 679 50483205
Expanded disability status scale score increased 31.18 11.46 16 121224 354 50483530
Injury 31.12 11.46 43 121197 48882 50435002
Thyroid neoplasm 30.82 11.46 40 121200 3467 50480417
Agranulocytosis 30.38 11.46 7 121233 21414 50462470
Liver function test abnormal 30.32 11.46 196 121044 44143 50439741
Rhinorrhoea 30.21 11.46 48 121192 51535 50432349
Decreased immune responsiveness 30.13 11.46 42 121198 3899 50479985
Poor venous access 29.60 11.46 72 121168 10268 50473616
Pulmonary sarcoidosis 29.53 11.46 21 121219 852 50483032
Mammoplasty 29.26 11.46 17 121223 484 50483400
Breech presentation 29.21 11.46 23 121217 1091 50482793
Drug dependence 28.95 11.46 6 121234 19753 50464131
Blood calcium decreased 28.91 11.46 7 121233 20699 50463185
Injection site inflammation 28.86 11.46 37 121203 3168 50480716
Gallbladder disorder 28.78 11.46 97 121143 16645 50467239
Rotator cuff syndrome 28.49 11.46 76 121164 11468 50472416
Atrial fibrillation 28.45 11.46 136 121104 101609 50382275
Central venous catheterisation 28.25 11.46 30 121210 2100 50481784
Product administered at inappropriate site 28.22 11.46 32 121208 2411 50481473
Drug ineffective for unapproved indication 28.18 11.46 8 121232 21273 50462611
Haemorrhage in pregnancy 28.02 11.46 27 121213 1682 50482202
Prolonged labour 27.97 11.46 17 121223 527 50483357
Upper gastrointestinal haemorrhage 27.77 11.46 3 121237 16032 50467852
COVID-19 27.73 11.46 43 121197 46619 50437265
Anal incontinence 27.71 11.46 75 121165 11415 50472469
Epistaxis 27.64 11.46 71 121169 63883 50420001
Diplegia 27.63 11.46 21 121219 945 50482939
Product prescribing error 27.53 11.46 8 121232 20953 50462931
Colon cancer stage III 27.46 11.46 10 121230 91 50483793
Pain in jaw 27.34 11.46 31 121209 38397 50445487
Varicose vein 27.33 11.46 42 121198 4258 50479626
Cytomegalovirus infection 27.28 11.46 5 121235 17957 50465927
Irritable bowel syndrome 27.27 11.46 51 121189 51390 50432494
No adverse event 27.12 11.46 155 121085 33423 50450461
Rash maculo-papular 27.12 11.46 15 121225 26626 50457258
Brain neoplasm 27.06 11.46 39 121201 3734 50480150
Fluid retention 27.04 11.46 50 121190 50599 50433285
Osteoarthritis 26.95 11.46 267 120973 68339 50415545
JC polyomavirus test 26.74 11.46 8 121232 36 50483848
Ataxia 26.52 11.46 83 121157 13703 50470181
Retinal tear 26.44 11.46 21 121219 1009 50482875
Cholestasis 26.29 11.46 14 121226 25387 50458497
Haemolytic uraemic syndrome 26.15 11.46 30 121210 2289 50481595
Raynaud's phenomenon 26.03 11.46 22 121218 1154 50482730
Anaphylactic reaction 25.75 11.46 57 121183 53998 50429886
Fear 25.64 11.46 85 121155 14464 50469420
Vertigo 25.60 11.46 212 121028 51620 50432264
Chronic leukaemia 25.60 11.46 6 121234 7 50483877
Injection site irritation 25.58 11.46 41 121199 4309 50479575
Hypercalcaemia 25.48 11.46 12 121228 23340 50460544
Porphyria non-acute 25.48 11.46 13 121227 284 50483600
Mental disorder 25.17 11.46 112 121128 21879 50462005
Delirium 24.86 11.46 33 121207 38159 50445725
Oropharyngeal pain 24.79 11.46 99 121141 77702 50406182
Pneumocystis jirovecii pneumonia 24.75 11.46 3 121237 14660 50469224
Hernia 24.75 11.46 64 121176 9479 50474405
Back disorder 24.75 11.46 63 121177 9242 50474642
Eosinophilia 24.72 11.46 7 121233 18645 50465239
Rectocele 24.71 11.46 19 121221 870 50483014
Muscle tightness 24.69 11.46 67 121173 10213 50473671
Ligament sprain 24.68 11.46 68 121172 10457 50473427
Vitamin D decreased 24.56 11.46 59 121181 8347 50475537
Obstructive airways disorder 24.55 11.46 4 121236 15648 50468236
Cellulitis staphylococcal 24.48 11.46 17 121223 664 50483220
Uterine disorder 24.46 11.46 31 121209 2624 50481260
Hepatitis C 24.46 11.46 43 121197 4874 50479010
Chronic kidney disease 24.26 11.46 36 121204 39735 50444149
Pain in extremity 23.72 11.46 837 120403 272028 50211856
Anti-interferon antibody positive 23.66 11.46 6 121234 12 50483872
Headache 23.55 11.46 1459 119781 505076 49978808
Benign lung neoplasm 23.43 11.46 8 121232 59 50483825
Illness 23.31 11.46 15 121225 24525 50459359
Neuralgia 23.27 11.46 109 121131 21754 50462130
Blood pressure fluctuation 23.27 11.46 31 121209 35792 50448092
Thyroid function test abnormal 23.25 11.46 34 121206 3298 50480586
Intervertebral disc operation 23.08 11.46 16 121224 623 50483261
Throat irritation 23.07 11.46 23 121217 30216 50453668
Knee arthroplasty 23.02 11.46 156 121084 35690 50448194
Dysgeusia 22.99 11.46 36 121204 38880 50445004
Fibula fracture 22.88 11.46 32 121208 2980 50480904
Blood pressure diastolic decreased 22.80 11.46 6 121234 16775 50467109
Dry skin 22.73 11.46 43 121197 43148 50440736
Blood potassium decreased 22.67 11.46 159 121081 36786 50447098
Withdrawal syndrome 22.58 11.46 7 121233 17583 50466301
Haematuria 22.55 11.46 17 121223 25596 50458288
Breast cancer recurrent 22.54 11.46 36 121204 3772 50480112
Endometrial cancer 22.45 11.46 31 121209 2852 50481032
Cellulitis 22.45 11.46 264 120976 70534 50413350
Heavy menstrual bleeding 22.42 11.46 85 121155 15452 50468432
Thermal burn 22.37 11.46 41 121199 4800 50479084
Calculus bladder 22.34 11.46 15 121225 554 50483330
Injection site anaesthesia 22.32 11.46 7 121233 38 50483846
Urinary tract disorder 22.26 11.46 28 121212 2352 50481532
Tachypnoea 22.26 11.46 4 121236 14573 50469311
Partial seizures 22.23 11.46 41 121199 4824 50479060
Febrile convulsion 22.16 11.46 13 121227 377 50483507
Hemianaesthesia 22.16 11.46 13 121227 377 50483507
Angioedema 22.12 11.46 35 121205 37641 50446243
Conversion disorder 22.09 11.46 23 121217 1573 50482311
Acute respiratory failure 21.83 11.46 22 121218 28760 50455124
Nerve injury 21.66 11.46 56 121184 8294 50475590
Dry eye 21.65 11.46 27 121213 32068 50451816
Dry mouth 21.58 11.46 66 121174 56112 50427772
Cartilage injury 21.55 11.46 23 121217 1619 50482265
Leukopenia 21.46 11.46 86 121154 67442 50416442
Rubber sensitivity 21.41 11.46 24 121216 1785 50482099
Wound infection staphylococcal 21.36 11.46 28 121212 2451 50481433
Fear of injection 21.35 11.46 46 121194 6057 50477827
Face oedema 21.34 11.46 8 121232 17831 50466053
Haematemesis 21.25 11.46 21 121219 27704 50456180
Scoliosis 21.23 11.46 48 121192 6528 50477356
Haemoptysis 21.23 11.46 18 121222 25555 50458329
Product substitution issue 21.16 11.46 4 121236 14053 50469831
Gallbladder operation 21.12 11.46 25 121215 1972 50481912
Chronic lymphocytic leukaemia 21.12 11.46 27 121213 2306 50481578
Blindness transient 21.11 11.46 32 121208 3206 50480678
Suicidal behaviour 21.11 11.46 27 121213 2307 50481577
Intervertebral disc injury 21.07 11.46 9 121231 129 50483755
Incontinence 20.97 11.46 62 121178 9923 50473961
Goitre 20.83 11.46 42 121198 5278 50478606
Rash erythematous 20.82 11.46 32 121208 34820 50449064
Orthostatic hypotension 20.73 11.46 24 121216 29457 50454427
Dysarthria 20.67 11.46 157 121083 37246 50446638
Pulmonary oedema 20.63 11.46 55 121185 48883 50435001
Gun shot wound 20.54 11.46 8 121232 89 50483795
Foot fracture 20.54 11.46 99 121141 19992 50463892
Lumbar radiculopathy 20.39 11.46 23 121217 1723 50482161
Impaired self-care 20.33 11.46 23 121217 1728 50482156
Cervical dysplasia 20.29 11.46 29 121211 2756 50481128
Facial bones fracture 20.15 11.46 31 121209 3146 50480738
Benign hydatidiform mole 20.00 11.46 8 121232 96 50483788
Disseminated intravascular coagulation 19.97 11.46 8 121232 17127 50466757
Knee operation 19.72 11.46 39 121201 4834 50479050
Limb mass 19.70 11.46 28 121212 2647 50481237
Progesterone receptor assay positive 19.66 11.46 11 121229 291 50483593
Abnormal labour 19.59 11.46 7 121233 60 50483824
Breast cancer stage III 19.58 11.46 31 121209 3225 50480659
Panic attack 19.55 11.46 95 121145 19247 50464637
Demyelination 19.47 11.46 44 121196 5982 50477902
Urosepsis 19.41 11.46 81 121159 15384 50468500
Wrong technique in product usage process 19.40 11.46 68 121172 55442 50428442
Schwannoma 19.39 11.46 7 121233 62 50483822
Hyperglycaemia 19.37 11.46 36 121204 36369 50447515
Lipoatrophy 19.29 11.46 11 121229 302 50483582
Cholecystitis infective 19.28 11.46 21 121219 1513 50482371
Precancerous cells present 19.27 11.46 19 121221 1218 50482666
Fractured coccyx 19.26 11.46 17 121223 946 50482938
Wrist fracture 19.26 11.46 66 121174 11421 50472463
Fat necrosis 19.20 11.46 14 121226 591 50483293
Pollakiuria 19.20 11.46 110 121130 23741 50460143
Renal cell carcinoma 19.19 11.46 30 121210 3087 50480797
Emotional disorder 18.97 11.46 67 121173 11769 50472115
Spinal disorder 18.97 11.46 53 121187 8217 50475667
Incision site abscess 18.87 11.46 9 121231 169 50483715
Coronary artery disease 18.87 11.46 129 121111 29597 50454287
Frequent bowel movements 18.86 11.46 5 121235 13913 50469971
Rectal cancer 18.83 11.46 22 121218 1712 50482172
Creatinine renal clearance decreased 18.72 11.46 3 121237 11878 50472006
Gastrointestinal disorder 18.62 11.46 141 121099 94315 50389569
Foetal heart rate abnormal 18.60 11.46 13 121227 513 50483371
Plasma cell myeloma 18.48 11.46 29 121211 31293 50452591
Skin cancer 18.48 11.46 57 121183 9337 50474547
Ocular hyperaemia 18.47 11.46 13 121227 20279 50463605
Gait spastic 18.35 11.46 10 121230 251 50483633
Bone erosion 18.30 11.46 3 121237 11684 50472200
Oestrogen receptor assay positive 18.17 11.46 12 121228 431 50483453
Heat exhaustion 18.13 11.46 7 121233 76 50483808
Deafness unilateral 18.09 11.46 27 121213 2668 50481216
Oral candidiasis 17.99 11.46 9 121231 16906 50466978
Focal segmental glomerulosclerosis 17.98 11.46 19 121221 1322 50482562
Umbilical cord around neck 17.96 11.46 9 121231 189 50483695
Tubulointerstitial nephritis 17.90 11.46 7 121233 15204 50468680
Post procedural infection 17.82 11.46 49 121191 7527 50476357
Lung adenocarcinoma stage I 17.82 11.46 5 121235 17 50483867
Shock 17.81 11.46 14 121226 20636 50463248
Colostomy closure 17.77 11.46 8 121232 131 50483753
Arterial occlusive disease 17.70 11.46 37 121203 4771 50479113
Spondylolisthesis 17.68 11.46 29 121211 3108 50480776
Atrophy 17.68 11.46 20 121220 1503 50482381
Crying 17.66 11.46 96 121144 20320 50463564
Umbilical hernia 17.61 11.46 25 121215 2361 50481523
Right ventricular failure 17.60 11.46 8 121232 15885 50467999
Product administration error 17.44 11.46 13 121227 19686 50464198
Incisional hernia 17.43 11.46 19 121221 1370 50482514
Hepatic steatosis 17.41 11.46 109 121131 24275 50459609
Female genital operation 17.39 11.46 5 121235 19 50483865
Volvulus 17.38 11.46 20 121220 1531 50482353
Malignant melanoma in situ 17.38 11.46 15 121225 810 50483074
Oophorectomy 17.36 11.46 12 121228 465 50483419
Hepatocellular injury 17.32 11.46 22 121218 25925 50457959
Rectal haemorrhage 17.28 11.46 42 121198 38516 50445368
Cephalo-pelvic disproportion 17.26 11.46 9 121231 206 50483678
Anaesthetic complication 17.22 11.46 21 121219 1709 50482175
Skin exfoliation 17.22 11.46 34 121206 33578 50450306
JC polyomavirus test positive 17.21 11.46 17 121223 1092 50482792
Infection 17.21 11.46 301 120939 172653 50311231
Hand fracture 17.17 11.46 35 121205 4433 50479451
Incision site complication 17.14 11.46 13 121227 583 50483301
Post procedural haemorrhage 17.08 11.46 47 121193 7223 50476661
Optic atrophy 17.04 11.46 17 121223 1105 50482779
Ovarian neoplasm 16.96 11.46 15 121225 837 50483047
Blood urea increased 16.80 11.46 19 121221 23566 50460318
Magnetic resonance imaging head abnormal 16.77 11.46 21 121219 1756 50482128
Nodule 16.70 11.46 10 121230 16993 50466891
Lacrimation increased 16.68 11.46 10 121230 16982 50466902
Blood pressure decreased 16.65 11.46 73 121167 55836 50428048
Breast calcifications 16.63 11.46 17 121223 1138 50482746
Intervertebral disc displacement 16.56 11.46 11 121229 399 50483485
Feeling of body temperature change 16.54 11.46 34 121206 4333 50479551
Lumbar puncture 16.44 11.46 6 121234 55 50483829
Post procedural stroke 16.44 11.46 6 121234 55 50483829
Bone pain 16.40 11.46 58 121182 47171 50436713
Lyme disease 16.39 11.46 25 121215 2518 50481366
Haemorrhagic ovarian cyst 16.38 11.46 13 121227 624 50483260
Injection site hypertrophy 16.34 11.46 6 121234 56 50483828
Cervical vertebral fracture 16.32 11.46 23 121217 2157 50481727
Gastric cyst 16.28 11.46 7 121233 102 50483782
Myelosuppression 16.27 11.46 6 121234 13511 50470373
Heat stroke 16.27 11.46 13 121227 630 50483254
Pregnancy 16.26 11.46 124 121116 29453 50454431
Cardiac perforation 16.16 11.46 6 121234 58 50483826
Drug delivery system malfunction 16.14 11.46 15 121225 893 50482991
Thrombotic thrombocytopenic purpura 16.11 11.46 30 121210 3555 50480329
Stevens-Johnson syndrome 16.08 11.46 17 121223 21735 50462149
Carotid artery aneurysm 16.06 11.46 9 121231 239 50483645
Adrenal insufficiency 16.04 11.46 7 121233 14236 50469648
Skin graft 16.00 11.46 12 121228 529 50483355
Cardiac arrest 15.96 11.46 126 121114 83525 50400359
Enterocele 15.89 11.46 6 121234 61 50483823
Skull fracture 15.89 11.46 15 121225 911 50482973
Cerebral cyst 15.89 11.46 9 121231 244 50483640
Vaccination complication 15.88 11.46 14 121226 778 50483106
Basal cell carcinoma 15.81 11.46 103 121137 23253 50460631
Tumefactive multiple sclerosis 15.72 11.46 6 121234 63 50483821
Fibrocystic breast disease 15.69 11.46 16 121224 1068 50482816
Urinary tract infection staphylococcal 15.63 11.46 9 121231 252 50483632
Vein disorder 15.62 11.46 33 121207 4286 50479598
Lung disorder 15.57 11.46 55 121185 44744 50439140
Viral pericarditis 15.53 11.46 5 121235 30 50483854
Tenderness 15.49 11.46 13 121227 18552 50465332
Respiratory distress 15.48 11.46 31 121209 30458 50453426
Spider vein 15.47 11.46 9 121231 257 50483627
Muscle disorder 15.46 11.46 33 121207 4317 50479567
Aneurysm 15.41 11.46 24 121216 2461 50481423
Cholecystitis 15.39 11.46 70 121170 13801 50470083
Cerebral atrophy 15.32 11.46 34 121206 4567 50479317
Restlessness 15.14 11.46 23 121217 25150 50458734
Hypersensitivity 15.12 11.46 396 120844 214765 50269119
Faeces discoloured 15.12 11.46 10 121230 16114 50467770
Neurilemmoma benign 15.11 11.46 3 121237 0 50483884
Neurological complication associated with device 15.11 11.46 3 121237 0 50483884
Rectal cancer stage I 15.11 11.46 3 121237 0 50483884
Urinary control neurostimulator implantation 15.11 11.46 3 121237 0 50483884
Face presentation 15.11 11.46 3 121237 0 50483884
Biopsy bladder 15.11 11.46 3 121237 0 50483884
Breast dysplasia 15.11 11.46 3 121237 0 50483884
Urinary retention 15.07 11.46 111 121129 26079 50457805
Myoclonus 14.94 11.46 8 121232 14462 50469422
Large intestine polyp 14.90 11.46 45 121195 7287 50476597
Paraganglion neoplasm 14.89 11.46 4 121236 11 50483873
Injection related reaction 14.85 11.46 12 121228 591 50483293
Uterine mass 14.83 11.46 9 121231 278 50483606
Injection site hypoaesthesia 14.83 11.46 10 121230 372 50483512
Acute disseminated encephalomyelitis 14.78 11.46 8 121232 198 50483686
Rales 14.68 11.46 3 121237 9975 50473909
Paternal exposure before pregnancy 14.63 11.46 5 121235 37 50483847
Skin laceration 14.58 11.46 86 121154 18756 50465128
Musculoskeletal pain 14.58 11.46 107 121133 72070 50411814
Loss of consciousness 14.58 11.46 340 120900 104013 50379871
Oophorectomy bilateral 14.51 11.46 5 121235 38 50483846
Postoperative thrombosis 14.51 11.46 7 121233 135 50483749
Hypothyroidism 14.47 11.46 135 121105 33990 50449894
Colon cancer metastatic 14.42 11.46 15 121225 1025 50482859
Hepatotoxicity 14.42 11.46 27 121213 27199 50456685
Pancreatic cyst 14.41 11.46 17 121223 1336 50482548
Glioblastoma 14.38 11.46 13 121227 747 50483137
Circulatory collapse 14.37 11.46 16 121224 19984 50463900
Diabetic ketoacidosis 14.33 11.46 13 121227 17859 50466025
Homicidal ideation 14.32 11.46 19 121221 1683 50482201
Abdominal operation 14.26 11.46 11 121229 506 50483378
Endometrial cancer stage I 14.05 11.46 8 121232 219 50483665
Chondropathy 14.04 11.46 21 121219 2079 50481805
Malignant hypertension 14.02 11.46 15 121225 1059 50482825
Endometrial adenocarcinoma 14.01 11.46 15 121225 1060 50482824
Lung cancer metastatic 14.00 11.46 22 121218 2273 50481611
Spinal meningeal cyst 13.98 11.46 5 121235 43 50483841
Inappropriate antidiuretic hormone secretion 13.97 11.46 7 121233 13136 50470748
Product complaint 13.95 11.46 5 121235 11461 50472423
Uterine leiomyosarcoma 13.95 11.46 4 121236 15 50483869
Reproductive tract disorder 13.89 11.46 7 121233 149 50483735
Spinal fusion surgery 13.85 11.46 30 121210 3965 50479919
Meningitis viral 13.84 11.46 16 121224 1231 50482653
Arthritis 13.84 11.46 288 120952 86433 50397451
Incoherent 13.80 11.46 31 121209 4199 50479685
Rib fracture 13.77 11.46 86 121154 19135 50464749
Serum serotonin decreased 13.75 11.46 4 121236 16 50483868
Joint effusion 13.74 11.46 7 121233 13014 50470870
Gastrointestinal viral infection 13.67 11.46 14 121226 939 50482945
Intervertebral disc compression 13.67 11.46 14 121226 939 50482945
Intestinal cyst 13.62 11.46 6 121234 93 50483791
Normal newborn 13.54 11.46 41 121199 6650 50477234
Toxic skin eruption 13.53 11.46 5 121235 11246 50472638
Limb injury 13.52 11.46 89 121151 20161 50463723
Blood bilirubin increased 13.51 11.46 36 121204 32002 50451882
Cardiac disorder 13.50 11.46 160 121080 42819 50441065
Nephrotic syndrome 13.42 11.46 33 121207 4737 50479147
Disease progression 13.36 11.46 156 121084 95710 50388174
Bladder prolapse 13.32 11.46 19 121221 1802 50482082
Colon cancer stage IV 13.28 11.46 6 121234 99 50483785
Injection site rash 13.28 11.46 75 121165 16102 50467782
Benign pancreatic neoplasm 13.20 11.46 4 121236 19 50483865
Swelling face 13.17 11.46 73 121167 52522 50431362
Suture related complication 13.16 11.46 7 121233 167 50483717
Lung adenocarcinoma 13.15 11.46 30 121210 4104 50479780
Renal tubular necrosis 13.14 11.46 4 121236 10164 50473720
Adenomyosis 13.08 11.46 10 121230 454 50483430
Intestinal ulcer perforation 13.04 11.46 3 121237 3 50483881
Colostomy infection 13.04 11.46 3 121237 3 50483881
Cardiogenic shock 12.92 11.46 11 121229 15588 50468296
Adverse event 12.91 11.46 161 121079 43602 50440282
Ophthalmoplegia 12.91 11.46 16 121224 1324 50482560
Amniotic fluid volume decreased 12.91 11.46 10 121230 463 50483421
Hyperaesthesia 12.87 11.46 46 121194 8127 50475757
Eye pruritus 12.84 11.46 7 121233 12527 50471357
Exposure via father 12.82 11.46 8 121232 260 50483624
Fatigue 12.77 11.46 1906 119334 705695 49778189
Lipoma excision 12.71 11.46 4 121236 22 50483862
Dysphonia 12.69 11.46 49 121191 38843 50445041
Encephalopathy 12.67 11.46 40 121200 33671 50450213
Device dislocation 12.66 11.46 20 121220 21526 50462358
Spinal cord disorder 12.59 11.46 15 121225 1192 50482692
Non-small cell lung cancer stage IIIB 12.58 11.46 3 121237 4 50483880
Dysphemia 12.57 11.46 21 121219 2285 50481599
Immunology test abnormal 12.56 11.46 4 121236 23 50483861
Renal cancer 12.54 11.46 27 121213 3553 50480331
Hypoalbuminaemia 12.52 11.46 4 121236 9856 50474028
Clavicle fracture 12.47 11.46 24 121216 2915 50480969
Sarcoma 12.47 11.46 9 121231 374 50483510
Inappropriate schedule of product administration 12.43 11.46 111 121129 71720 50412164
Cerebral thrombosis 12.42 11.46 17 121223 1551 50482333
Hepatic adenoma 12.40 11.46 8 121232 276 50483608
Post procedural swelling 12.37 11.46 8 121232 277 50483607
Parkinsonism 12.33 11.46 3 121237 8844 50475040
Myelitis 12.32 11.46 15 121225 1219 50482665
Benign uterine neoplasm 12.28 11.46 4 121236 25 50483859
Uterine polyp 12.28 11.46 18 121222 1750 50482134
Altered state of consciousness 12.26 11.46 21 121219 21889 50461995
Abortion missed 12.26 11.46 17 121223 1571 50482313
Hallucination, visual 12.21 11.46 13 121227 16569 50467315
Ventricular fibrillation 12.19 11.46 5 121235 10554 50473330
Pituitary tumour benign 12.18 11.46 18 121222 1763 50482121
Intentional self-injury 12.17 11.46 23 121217 23089 50460795
Nasal sinus cancer 12.15 11.46 4 121236 26 50483858
Progressive relapsing multiple sclerosis 12.15 11.46 4 121236 26 50483858
Skin indentation 12.15 11.46 4 121236 26 50483858
Female sterilisation 12.14 11.46 10 121230 506 50483378
Back injury 12.13 11.46 41 121199 7044 50476840
Gingival bleeding 12.13 11.46 6 121234 11347 50472537
Allergy to metals 12.13 11.46 10 121230 507 50483377
Hepatic function abnormal 12.12 11.46 39 121201 32642 50451242
Polyneuropathy 12.10 11.46 7 121233 12124 50471760
Injection site swelling 12.04 11.46 153 121087 41620 50442264
Brain operation 12.02 11.46 10 121230 513 50483371
Cast application 12.02 11.46 4 121236 27 50483857
Eye irritation 12.00 11.46 14 121226 17126 50466758
Cold type haemolytic anaemia 11.96 11.46 7 121233 202 50483682
Injection site vesicles 11.96 11.46 22 121218 2583 50481301
Anuria 11.93 11.46 6 121234 11238 50472646
Complication of pregnancy 11.92 11.46 10 121230 519 50483365
Exposure during pregnancy 11.90 11.46 211 121029 120804 50363080
Synovial sarcoma 11.90 11.46 4 121236 28 50483856
Uterine cyst 11.88 11.46 9 121231 403 50483481
Spinal laminectomy 11.86 11.46 11 121229 653 50483231
Suture rupture 11.84 11.46 7 121233 206 50483678
Non-small cell lung cancer stage I 11.83 11.46 3 121237 6 50483878
Lhermitte's sign 11.83 11.46 3 121237 6 50483878
Small cell lung cancer extensive stage 11.83 11.46 3 121237 6 50483878
Facial paralysis 11.82 11.46 61 121179 12654 50471230
Benign neoplasm of thyroid gland 11.81 11.46 13 121227 948 50482936
Urticaria 11.78 11.46 229 121011 129332 50354552
Petit mal epilepsy 11.75 11.46 25 121215 3264 50480620
Patella fracture 11.72 11.46 18 121222 1824 50482060
Large intestinal obstruction 11.67 11.46 18 121222 1831 50482053
Radiculopathy 11.66 11.46 32 121208 4909 50478975
Arterial therapeutic procedure 11.66 11.46 4 121236 30 50483854
Uterine prolapse 11.60 11.46 14 121226 1127 50482757
Vulval cancer 11.60 11.46 11 121229 672 50483212
Pharyngitis 11.52 11.46 15 121225 17488 50466396
Ovarian cancer stage III 11.52 11.46 7 121233 217 50483667
Injection site dryness 11.49 11.46 7 121233 218 50483666

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Multiple sclerosis relapse 3141.53 14.39 914 27880 10505 29535228
Influenza like illness 1417.53 14.39 616 28178 23854 29521879
General symptom 307.22 14.39 84 28710 744 29544989
Gait disturbance 303.39 14.39 365 28429 72984 29472749
Injection site erythema 301.75 14.39 181 28613 13775 29531958
Central nervous system lesion 255.68 14.39 120 28674 5528 29540205
Fall 229.52 14.39 521 28273 176657 29369076
Urinary tract infection 222.28 14.39 311 28483 72043 29473690
Memory impairment 219.19 14.39 221 28573 36249 29509484
Injection site pain 201.18 14.39 200 28594 32246 29513487
Balance disorder 188.31 14.39 203 28591 35967 29509766
Mobility decreased 180.67 14.39 170 28624 25610 29520123
Hypoaesthesia 168.83 14.39 233 28561 53234 29492499
Muscle spasticity 167.87 14.39 86 28708 4797 29540936
Depression 161.87 14.39 294 28500 84853 29460880
Injection site infection 149.04 14.39 49 28745 852 29544881
Cognitive disorder 140.36 14.39 142 28652 23357 29522376
Off label use 140.29 14.39 59 28735 300741 29244992
Acute kidney injury 137.20 14.39 44 28750 265223 29280510
Toxicity to various agents 137.12 14.39 8 28786 173653 29372080
Injection site reaction 132.74 14.39 100 28694 11088 29534645
Progressive multiple sclerosis 131.44 14.39 33 28761 201 29545532
Drug interaction 129.73 14.39 19 28775 197366 29348367
Muscular weakness 123.89 14.39 219 28575 61833 29483900
Optic neuritis 122.29 14.39 60 28734 3049 29542684
Secondary progressive multiple sclerosis 121.54 14.39 34 28760 330 29545403
Loss of control of legs 120.81 14.39 37 28757 505 29545228
Gait inability 120.78 14.39 117 28677 18258 29527475
Injection site cellulitis 119.15 14.39 36 28758 468 29545265
Diarrhoea 107.26 14.39 100 28694 332598 29213135
Magnetic resonance imaging abnormal 106.46 14.39 44 28750 1487 29544246
Myocardial infarction 106.07 14.39 290 28504 110006 29435727
Decubitus ulcer 101.80 14.39 72 28722 7239 29538494
Injection site abscess 99.21 14.39 34 28760 675 29545058
Relapsing-remitting multiple sclerosis 94.29 14.39 33 28761 699 29545034
Needle fatigue 92.72 14.39 31 28763 569 29545164
Dyspnoea 86.82 14.39 115 28679 326617 29219116
Anaemia 84.91 14.39 45 28749 200906 29344827
Trigeminal neuralgia 83.56 14.39 33 28761 989 29544744
Seizure 82.74 14.39 238 28556 92885 29452848
Intervertebral disc protrusion 82.38 14.39 68 28726 8602 29537131
Gait spastic 77.13 14.39 28 28766 662 29545071
Neutropenia 77.10 14.39 17 28777 131694 29414039
Road traffic accident 73.40 14.39 83 28711 15478 29530255
Hypotension 73.02 14.39 50 28744 194304 29351429
Coronary artery occlusion 69.58 14.39 66 28728 10028 29535705
Hypertonic bladder 69.17 14.39 32 28762 1424 29544309
Cystitis 68.47 14.39 60 28734 8232 29537501
Coordination abnormal 68.01 14.39 56 28738 7058 29538675
Injection site induration 67.82 14.39 38 28756 2538 29543195
Bladder disorder 62.32 14.39 37 28757 2757 29542976
Multiple sclerosis 62.24 14.39 48 28746 5506 29540227
Visual impairment 60.70 14.39 106 28688 29602 29516131
Injection site haematoma 58.69 14.39 29 28765 1496 29544237
Thrombocytopenia 58.66 14.39 29 28765 134794 29410939
Musculoskeletal disorder 58.10 14.39 45 28749 5195 29540538
Monoparesis 55.40 14.39 30 28764 1873 29543860
Adverse drug reaction 54.75 14.39 90 28704 23930 29521803
Injection site necrosis 52.35 14.39 18 28776 361 29545372
Neurogenic bladder 51.75 14.39 27 28767 1563 29544170
Ataxia 51.12 14.39 61 28733 12042 29533691
Procedural anxiety 50.83 14.39 9 28785 3 29545730
Injection site scar 50.01 14.39 16 28778 254 29545479
Blood creatinine increased 49.74 14.39 11 28783 85091 29460642
Injection site bruising 49.29 14.39 48 28746 7532 29538201
Prostate cancer 48.19 14.39 88 28706 25439 29520294
Hyponatraemia 48.02 14.39 5 28789 67628 29478105
Anxiety 44.73 14.39 183 28611 85182 29460551
Interstitial lung disease 44.45 14.39 3 28791 57715 29488018
Peroneal nerve palsy 43.87 14.39 29 28765 2610 29543123
Pain 43.71 14.39 301 28493 171131 29374602
Haemoglobin decreased 43.21 14.39 26 28768 108349 29437384
Muscle spasms 42.76 14.39 150 28644 64932 29480801
Drug delivery device placement 42.48 14.39 12 28782 121 29545612
Hyperkalaemia 42.42 14.39 5 28789 61387 29484346
Nausea 42.04 14.39 143 28651 289112 29256621
Micturition urgency 41.84 14.39 37 28757 5136 29540597
Renal impairment 41.00 14.39 14 28780 81319 29464414
Abdominal pain 40.76 14.39 43 28751 135314 29410419
Respiratory failure 40.58 14.39 22 28772 97109 29448624
Product use in unapproved indication 40.39 14.39 17 28777 86858 29458875
Drug abuse 39.84 14.39 14 28780 79869 29465864
Dysstasia 39.72 14.39 50 28744 10424 29535309
Platelet count decreased 39.15 14.39 27 28767 104645 29441088
Pancytopenia 39.10 14.39 16 28778 83152 29462581
Chills 39.05 14.39 155 28639 71145 29474588
Primary progressive multiple sclerosis 38.58 14.39 9 28785 38 29545695
Amnesia 37.70 14.39 74 28720 22569 29523164
Rash 37.18 14.39 81 28713 189738 29355995
Pleural effusion 36.90 14.39 12 28782 71896 29473837
Injection site haemorrhage 36.63 14.39 43 28751 8343 29537390
Decreased appetite 36.59 14.39 53 28741 145289 29400444
Product use issue 36.01 14.39 4 28790 51440 29494293
Glioblastoma 35.90 14.39 18 28776 958 29544775
Bipolar disorder 35.88 14.39 28 28766 3267 29542466
Lower limb fracture 35.43 14.39 29 28765 3623 29542110
Spinal fusion surgery 35.23 14.39 17 28777 832 29544901
Blindness unilateral 34.60 14.39 29 28765 3745 29541988
Generalised tonic-clonic seizure 33.64 14.39 64 28730 19075 29526658
Speech disorder 33.43 14.39 72 28722 23444 29522289
Influenza 33.29 14.39 103 28691 41778 29503955
Drug specific antibody present 32.85 14.39 24 28770 2537 29543196
Hemiparesis 32.63 14.39 54 28740 14432 29531301
Neutralising antibodies positive 32.48 14.39 9 28785 84 29545649
Paralysis 32.39 14.39 33 28761 5464 29540269
Head injury 32.34 14.39 57 28737 16024 29529709
Injury associated with device 32.20 14.39 16 28778 835 29544898
Dysarthria 31.35 14.39 83 28711 30828 29514905
Movement disorder 31.32 14.39 44 28750 10193 29535540
Adverse reaction 31.13 14.39 24 28770 2751 29542982
Hypoglycaemia 30.89 14.39 5 28789 48341 29497392
Tachycardia 30.82 14.39 16 28778 72394 29473339
Concussion 30.46 14.39 21 28773 2025 29543708
Hypokalaemia 30.33 14.39 6 28788 50197 29495536
Cough 30.17 14.39 48 28746 126679 29419054
Lack of injection site rotation 29.24 14.39 9 28785 125 29545608
Asthenia 29.20 14.39 329 28465 214921 29330812
Cerebrovascular accident 29.19 14.39 150 28644 76761 29468972
Staphylococcal infection 28.13 14.39 77 28717 29163 29516570
Gastrointestinal haemorrhage 27.80 14.39 22 28772 79511 29466222
Thyroid cancer 27.70 14.39 17 28777 1345 29544388
Hepatic enzyme increased 27.67 14.39 84 28710 33715 29512018
Agraphia 27.07 14.39 6 28788 19 29545714
Tremor 26.92 14.39 142 28652 73396 29472337
Rhabdomyolysis 26.53 14.39 13 28781 60795 29484938
Ankle fracture 26.41 14.39 24 28770 3452 29542281
Cardiac failure 26.40 14.39 23 28771 79264 29466469
Progressive relapsing multiple sclerosis 25.74 14.39 5 28789 6 29545727
Superficial vein prominence 25.74 14.39 5 28789 6 29545727
Muscle tightness 25.49 14.39 26 28768 4312 29541421
C-reactive protein increased 25.29 14.39 6 28788 44257 29501476
Urinary incontinence 25.21 14.39 52 28742 16429 29529304
Headache 24.96 14.39 269 28525 173738 29371995
Nephrolithiasis 24.65 14.39 67 28727 25267 29520466
Frustration tolerance decreased 24.23 14.39 19 28775 2233 29543500
Fear of injection 24.03 14.39 13 28781 810 29544923
Multiple organ dysfunction syndrome 23.96 14.39 16 28778 63100 29482633
Post procedural complication 23.76 14.39 39 28755 10350 29535383
Diabetes mellitus 23.76 14.39 89 28705 39742 29505991
Neurofibroma 23.74 14.39 4 28790 0 29545733
Paraparesis 23.69 14.39 17 28777 1747 29543986
Septic shock 23.56 14.39 16 28778 62544 29483189
Injection site inflammation 23.35 14.39 12 28782 673 29545060
Cardio-respiratory arrest 23.35 14.39 10 28784 50591 29495142
Paraesthesia 23.27 14.39 109 28685 53736 29491997
Neuropathy peripheral 23.17 14.39 21 28773 71006 29474727
Ascites 22.92 14.39 4 28790 36615 29509118
Neutrophil count decreased 22.83 14.39 7 28787 43560 29502173
Injection site atrophy 22.48 14.39 6 28788 48 29545685
Injection site mass 22.22 14.39 27 28767 5428 29540305
Suicidal ideation 21.91 14.39 79 28715 34637 29511096
Temperature intolerance 21.86 14.39 20 28774 2901 29542832
Overweight 21.79 14.39 15 28779 1443 29544290
Chronic lymphocytic leukaemia 21.75 14.39 22 28772 3611 29542122
Injection site injury 21.65 14.39 8 28786 199 29545534
Completed suicide 21.63 14.39 34 28760 90212 29455521
Cardiac valve rupture 21.51 14.39 4 28790 3 29545730
Dysgraphia 21.50 14.39 17 28777 2021 29543712
Feeling abnormal 21.21 14.39 107 28687 54338 29491395
Epistaxis 21.16 14.39 12 28782 51692 29494041
Rectal haemorrhage 21.14 14.39 4 28790 34545 29511188
Hip arthroplasty 21.13 14.39 22 28772 3736 29541997
Hepatic function abnormal 21.13 14.39 6 28788 39253 29506480
Osteonecrosis 21.08 14.39 43 28751 13476 29532257
Stress 21.07 14.39 57 28737 21433 29524300
Insomnia 20.90 14.39 153 28641 88608 29457125
Blood cholesterol increased 20.19 14.39 46 28748 15549 29530184
Injection site ulcer 20.18 14.39 8 28786 242 29545491
Vein disorder 19.89 14.39 12 28782 920 29544813
Pollakiuria 19.83 14.39 48 28746 16868 29528865
Hospitalisation 19.81 14.39 10 28784 45978 29499755
Diplegia 19.69 14.39 12 28782 937 29544796
Lactic acidosis 19.61 14.39 3 28791 30244 29515489
Stomatitis 19.38 14.39 6 28788 37107 29508626
Intervertebral disc disorder 19.37 14.39 15 28779 1730 29544003
JC polyomavirus test positive 19.37 14.39 10 28784 566 29545167
Intentional product misuse 19.21 14.39 5 28789 34656 29511077
Overdose 19.20 14.39 30 28764 79789 29465944
Feeling cold 19.02 14.39 33 28761 9158 29536575
Surgery 19.01 14.39 38 28756 11741 29533992
Urosepsis 18.96 14.39 36 28758 10710 29535023
Pruritus 18.85 14.39 55 28739 116794 29428939
Blood creatine phosphokinase increased 18.80 14.39 8 28786 40636 29505097
Sensory disturbance 18.64 14.39 25 28769 5544 29540189
Hernia 18.61 14.39 31 28763 8327 29537406
Injection site irritation 18.51 14.39 12 28782 1045 29544688
Blindness 18.46 14.39 38 28756 11985 29533748
Vomiting 18.43 14.39 126 28668 212134 29333599
Productive cough 18.33 14.39 4 28790 31255 29514478
Weight increased 18.26 14.39 29 28765 76638 29469095
Hypoxia 17.99 14.39 12 28782 47367 29498366
Glioblastoma multiforme 17.86 14.39 10 28784 667 29545066
Neutralising antibodies 17.81 14.39 3 28791 0 29545733
B-cell lymphoma stage I 17.81 14.39 3 28791 0 29545733
Diplopia 17.64 14.39 40 28754 13478 29532255
Anger 17.41 14.39 35 28759 10855 29534878
Nocturia 17.28 14.39 30 28764 8332 29537401
Oedema 17.14 14.39 9 28785 40474 29505259
No adverse event 16.78 14.39 46 28748 17432 29528301
Anal incontinence 16.73 14.39 26 28768 6589 29539144
Mood altered 16.63 14.39 29 28765 8082 29537651
Vaccination complication 16.62 14.39 5 28789 64 29545669
Depressed mood 16.50 14.39 44 28750 16404 29529329
Mood swings 16.29 14.39 27 28767 7224 29538509
Injection site dryness 16.28 14.39 4 28790 22 29545711
Therapeutic product effect incomplete 16.26 14.39 9 28785 39296 29506437
Peripheral swelling 16.26 14.39 23 28771 63716 29482017
Accident 16.25 14.39 19 28775 3669 29542064
Oxygen saturation decreased 16.25 14.39 12 28782 44925 29500808
Injection site pruritus 16.23 14.39 24 28770 5825 29539908
Drug intolerance 16.06 14.39 91 28703 48288 29497445
Back disorder 15.84 14.39 24 28770 5949 29539784
Cholelithiasis 15.84 14.39 47 28747 18625 29527108
Medical induction of coma 15.73 14.39 3 28791 3 29545730
Procedural pain 15.68 14.39 20 28774 4224 29541509
Vision blurred 15.67 14.39 79 28715 40097 29505636
Pneumonitis 15.63 14.39 4 28790 28040 29517693
Ophthalmoplegia 15.57 14.39 13 28781 1669 29544064
Appendicitis perforated 15.43 14.39 13 28781 1690 29544043
Somnolence 15.31 14.39 44 28750 93911 29451822
Prostate cancer stage II 15.07 14.39 9 28785 678 29545055
Umbilical cord around neck 15.03 14.39 6 28788 185 29545548
Brain neoplasm 14.97 14.39 16 28778 2800 29542933
Therapeutic response decreased 14.82 14.39 3 28791 24708 29521025
Scar 14.69 14.39 22 28772 5397 29540336
Magnetic resonance imaging head abnormal 14.68 14.39 11 28783 1208 29544525
Wheezing 14.66 14.39 7 28787 33233 29512500
Intentional product use issue 14.54 14.39 12 28782 42486 29503247
Renal surgery 14.52 14.39 3 28791 6 29545727
Fatigue 14.46 14.39 407 28387 316414 29229319
Haematuria 14.45 14.39 13 28781 44126 29501607
Feeling of body temperature change 14.40 14.39 11 28783 1243 29544490

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Multiple sclerosis relapse 8294.98 11.64 2939 101591 38196 64356006
Influenza like illness 4151.15 11.64 2014 102516 59688 64334514
Fall 932.93 11.64 2070 102460 414756 63979446
Gait disturbance 723.25 11.64 1123 103407 171032 64223170
General symptom 704.45 11.64 224 104306 2004 64392198
Breast cancer 667.15 11.64 474 104056 28674 64365528
Off label use 635.08 11.64 128 104402 632678 63761524
Urinary tract infection 511.37 11.64 1146 103384 230450 64163752
Central nervous system lesion 495.22 11.64 282 104248 11567 64382635
Memory impairment 488.75 11.64 647 103883 85035 64309167
Optic neuritis 479.09 11.64 243 104287 7873 64386329
Balance disorder 472.95 11.64 630 103900 83296 64310906
Toxicity to various agents 462.50 11.64 33 104497 363480 64030722
Injection site pain 455.10 11.64 718 103812 110690 64283512
Hypoaesthesia 449.19 11.64 807 103723 138301 64255901
Depression 436.12 11.64 935 103595 182356 64211846
Injection site erythema 416.67 11.64 543 103987 70257 64323945
Loss of control of legs 373.94 11.64 130 104400 1569 64392633
Drug interaction 365.03 11.64 72 104458 362011 64032191
Intervertebral disc protrusion 343.40 11.64 275 104255 19916 64374286
Acute kidney injury 341.12 11.64 151 104379 449089 63945113
Seizure 338.28 11.64 799 103731 166093 64228109
Gait inability 337.58 11.64 379 104151 41989 64352213
Diarrhoea 316.06 11.64 427 104103 722277 63671925
Muscular weakness 300.76 11.64 648 103882 126690 64267512
Secondary progressive multiple sclerosis 280.87 11.64 97 104433 1146 64393056
Muscle spasticity 262.31 11.64 217 104313 16452 64377750
Magnetic resonance imaging abnormal 258.71 11.64 118 104412 3005 64391197
Febrile neutropenia 257.02 11.64 11 104519 187646 64206556
Decubitus ulcer 246.39 11.64 191 104339 13188 64381014
Breast cancer female 244.78 11.64 133 104397 4970 64389232
Injection site bruising 244.11 11.64 298 104232 36075 64358127
Dyspnoea 242.34 11.64 502 104028 718172 63676030
Uterine leiomyoma 233.01 11.64 131 104399 5238 64388964
Stress 230.35 11.64 378 104152 60156 64334046
Neutropenia 224.43 11.64 56 104474 239568 64154634
Hysterectomy 215.08 11.64 122 104408 4963 64389239
Product use in unapproved indication 213.35 11.64 20 104510 176598 64217604
Road traffic accident 209.74 11.64 254 104276 30491 64363711
Injection site haemorrhage 205.10 11.64 224 104306 24054 64370148
Mobility decreased 203.89 11.64 438 104092 85402 64308800
Ankle fracture 203.81 11.64 178 104352 14532 64379670
Completed suicide 203.38 11.64 56 104474 224358 64169844
Trigeminal neuralgia 200.90 11.64 99 104431 3010 64391192
Rash 200.86 11.64 270 104260 458279 63935923
Progressive multiple sclerosis 198.96 11.64 67 104463 729 64393473
Product use issue 197.90 11.64 12 104518 151703 64242499
Injection site infection 195.01 11.64 83 104447 1782 64392420
Myocardial infarction 190.89 11.64 647 103883 165174 64229028
Injection site reaction 187.88 11.64 299 104231 46365 64347837
Injection site cellulitis 187.06 11.64 76 104454 1445 64392757
Coronary artery occlusion 186.27 11.64 165 104365 13726 64380476
Drug ineffective 181.07 11.64 726 103804 839521 63554681
Hypotension 180.67 11.64 211 104319 380763 64013439
Abortion spontaneous 175.22 11.64 210 104320 24933 64369269
Injection site abscess 169.01 11.64 69 104461 1329 64392873
Musculoskeletal disorder 168.57 11.64 175 104355 17731 64376471
Lower limb fracture 158.38 11.64 149 104381 13396 64380806
Malignant neoplasm progression 156.57 11.64 6 104524 112865 64281337
Muscle spasms 155.91 11.64 543 103987 140480 64253722
Drug abuse 154.62 11.64 17 104513 132357 64261845
Contraindicated product administered 152.12 11.64 5 104525 107824 64286378
Pancytopenia 151.74 11.64 25 104505 143284 64250918
Coordination abnormal 145.83 11.64 149 104381 14815 64379387
Thyroid cancer 143.02 11.64 86 104444 3905 64390297
Synovitis 141.94 11.64 4 104526 99086 64295116
Therapeutic product effect incomplete 141.85 11.64 6 104524 103476 64290726
Bladder disorder 141.09 11.64 110 104420 7657 64386545
Abdominal pain 140.63 11.64 180 104350 312195 64082007
Cystitis 139.29 11.64 249 104281 42426 64351776
Injection site haematoma 138.95 11.64 84 104446 3852 64390350
Hyponatraemia 138.16 11.64 35 104495 148304 64245898
Blood creatinine increased 136.59 11.64 27 104503 135755 64258447
Relapsing-remitting multiple sclerosis 135.02 11.64 55 104475 1053 64393149
Hyperkalaemia 134.94 11.64 7 104523 101122 64293080
Cognitive disorder 134.11 11.64 284 104246 54803 64339399
Peroneal nerve palsy 132.09 11.64 91 104439 5230 64388972
Anaemia 131.88 11.64 259 104271 378421 64015781
Chills 131.85 11.64 505 104025 136759 64257443
Cerebrovascular accident 131.20 11.64 505 104025 137078 64257124
Urinary incontinence 131.12 11.64 221 104309 35930 64358272
Infusion related reaction 129.78 11.64 52 104478 164415 64229787
Hip fracture 129.39 11.64 188 104342 26911 64367291
Injection site necrosis 128.78 11.64 56 104474 1269 64392933
Rheumatoid arthritis 124.73 11.64 55 104475 164239 64229963
Nausea 120.90 11.64 763 103767 785037 63609165
Thrombocytopenia 117.06 11.64 114 104416 223687 64170515
Post procedural complication 116.61 11.64 158 104372 21195 64373007
Breast cancer stage I 114.69 11.64 56 104474 1668 64392534
Cough 114.63 11.64 196 104334 301952 64092250
Stomatitis 114.07 11.64 20 104510 109585 64284617
Head injury 111.52 11.64 195 104335 32647 64361555
Adverse drug reaction 111.37 11.64 235 104295 45229 64348973
Caesarean section 111.21 11.64 113 104417 11161 64383041
Upper limb fracture 109.92 11.64 128 104402 14738 64379464
Multiple sclerosis 109.33 11.64 144 104386 18797 64375405
Breast cancer in situ 108.71 11.64 44 104486 828 64393374
Joint swelling 107.75 11.64 114 104416 215268 64178934
C-reactive protein increased 103.99 11.64 15 104515 94894 64299308
Injection site scar 102.77 11.64 40 104490 676 64393526
Amnesia 101.84 11.64 235 104295 48034 64346168
Interstitial lung disease 101.34 11.64 18 104512 97714 64296488
Neurogenic bladder 99.64 11.64 66 104464 3553 64390649
Dysstasia 99.32 11.64 153 104377 23062 64371140
Electrocardiogram QT prolonged 98.60 11.64 8 104522 79440 64314762
Migraine 97.63 11.64 272 104258 62405 64331797
Decreased appetite 97.32 11.64 193 104337 281096 64113106
Visual impairment 95.88 11.64 301 104229 73776 64320426
Peripheral swelling 94.59 11.64 120 104410 209033 64185169
Haemoglobin decreased 94.51 11.64 106 104424 194957 64199245
Diabetes mellitus 92.46 11.64 277 104253 66197 64328005
Pruritus 91.28 11.64 235 104295 312165 64082037
Drug hypersensitivity 90.40 11.64 154 104376 237661 64156541
Hypokalaemia 89.11 11.64 43 104487 121860 64272342
General physical health deterioration 87.63 11.64 122 104408 204303 64189899
Breast cancer stage II 87.21 11.64 44 104486 1408 64392794
Nephrolithiasis 87.06 11.64 208 104322 43475 64350727
Renal impairment 86.62 11.64 56 104474 134961 64259241
Asthenia 83.77 11.64 1060 103470 426984 63967218
Intentional product use issue 82.29 11.64 26 104504 95338 64298864
Hypoglycaemia 82.17 11.64 22 104508 89870 64304332
Procedural pain 82.03 11.64 113 104417 15395 64378807
Gastrointestinal haemorrhage 82.03 11.64 57 104473 132255 64261947
Pleural effusion 81.86 11.64 52 104478 126507 64267695
Paraesthesia 81.67 11.64 432 104098 134090 64260112
Mucosal inflammation 81.42 11.64 5 104525 62579 64331623
Metabolic acidosis 80.63 11.64 10 104520 70948 64323254
Ovarian cancer 80.59 11.64 56 104474 3263 64390939
Cholelithiasis 80.47 11.64 207 104323 45299 64348903
Platelet count decreased 80.29 11.64 92 104438 167619 64226583
Invasive ductal breast carcinoma 80.06 11.64 66 104464 4976 64389226
Multiple organ dysfunction syndrome 78.46 11.64 33 104497 101380 64292822
Intracranial aneurysm 78.16 11.64 57 104473 3586 64390616
Needle fatigue 77.91 11.64 31 104499 557 64393645
Blindness unilateral 76.42 11.64 73 104457 6688 64387514
Hemiparesis 76.34 11.64 157 104373 29670 64364532
Tachycardia 76.10 11.64 78 104452 149501 64244701
Tremor 76.06 11.64 455 104075 147775 64246427
Dyspnoea exertional 75.53 11.64 14 104516 73716 64320486
International normalised ratio increased 75.01 11.64 18 104512 79149 64315053
Respiratory failure 74.40 11.64 91 104439 161092 64233110
Neutrophil count decreased 74.23 11.64 17 104513 77179 64317023
Lactic acidosis 73.98 11.64 7 104523 61403 64332799
Malignant melanoma 73.96 11.64 98 104432 12866 64381336
Melaena 73.72 11.64 3 104527 53545 64340657
Neuromyelitis optica spectrum disorder 72.94 11.64 33 104497 824 64393378
Kidney infection 72.73 11.64 115 104415 17723 64376479
Therapeutic product effect decreased 72.43 11.64 49 104481 115302 64278900
Oxygen saturation decreased 72.15 11.64 42 104488 107134 64287068
Anxiety 71.86 11.64 568 103962 202081 64192121
Drug delivery device placement 71.66 11.64 22 104508 173 64394029
Glossodynia 71.39 11.64 10 104520 64686 64329516
Hypertension 70.31 11.64 685 103845 258576 64135626
Staphylococcal infection 70.30 11.64 211 104319 50467 64343735
Injection site mass 69.95 11.64 111 104419 17159 64377043
Gastric bypass 69.53 11.64 34 104496 1016 64393186
Gait spastic 68.56 11.64 32 104498 860 64393342
Lower respiratory tract infection 68.19 11.64 34 104496 94580 64299622
Oedema 67.84 11.64 32 104498 91903 64302299
Cardio-respiratory arrest 67.03 11.64 38 104492 98355 64295847
Intentional overdose 66.84 11.64 31 104499 89913 64304289
Sensory disturbance 66.52 11.64 94 104436 13114 64381088
Maternal exposure timing unspecified 66.49 11.64 46 104484 2661 64391541
Micturition urgency 66.46 11.64 83 104447 10276 64383926
Endometriosis 65.21 11.64 46 104484 2746 64391456
Cardiac failure 65.12 11.64 71 104459 132302 64261900
Concussion 64.88 11.64 72 104458 7866 64386336
Rhabdomyolysis 64.56 11.64 34 104496 91692 64302510
Injury associated with device 64.31 11.64 46 104484 2807 64391395
Treatment failure 63.98 11.64 57 104473 116759 64277443
Abdominal discomfort 63.95 11.64 124 104406 182198 64212004
Intentional product misuse 63.65 11.64 19 104511 72276 64321926
Hypoxia 63.04 11.64 32 104498 88117 64306085
Injection site induration 62.87 11.64 75 104455 8857 64385345
Overdose 62.76 11.64 101 104429 159465 64234737
Knee arthroplasty 60.89 11.64 135 104395 26864 64367338
Drug specific antibody present 58.92 11.64 56 104474 5098 64389104
Procedural anxiety 58.45 11.64 26 104504 623 64393579
Intervertebral disc degeneration 58.28 11.64 88 104442 13032 64381170
Appendicitis perforated 57.97 11.64 43 104487 2777 64391425
Productive cough 57.95 11.64 23 104507 73180 64321022
Lumbar spinal stenosis 57.93 11.64 53 104477 4597 64389605
Generalised tonic-clonic seizure 56.27 11.64 167 104363 39690 64354512
Intervertebral disc disorder 55.91 11.64 51 104479 4406 64389796
Septic shock 55.90 11.64 53 104477 105384 64288818
Speech disorder 55.62 11.64 189 104341 48252 64345950
Scar 55.49 11.64 87 104443 13311 64380891
Therapeutic response decreased 55.44 11.64 9 104521 52179 64342023
Bradycardia 55.33 11.64 66 104464 118153 64276049
Ligament rupture 55.14 11.64 40 104490 2496 64391706
Vomiting 54.88 11.64 600 103930 550517 63843685
Headache 54.82 11.64 1181 103349 528286 63865916
Bipolar disorder 54.70 11.64 61 104469 6700 64387502
Injection site ulcer 54.61 11.64 25 104505 642 64393560
Temperature intolerance 54.33 11.64 67 104463 8188 64386014
Influenza 53.98 11.64 326 104204 106205 64287997
Wheezing 53.63 11.64 32 104498 80547 64313655
Lung neoplasm malignant 52.67 11.64 111 104419 21337 64372865
Hypocalcaemia 52.37 11.64 4 104526 41749 64352453
Loss of personal independence in daily activities 52.26 11.64 26 104504 72428 64321774
Blood creatine phosphokinase increased 52.26 11.64 15 104515 58543 64335659
Appendicitis 51.93 11.64 85 104445 13484 64380718
Spinal stenosis 51.61 11.64 86 104444 13845 64380357
Intraductal proliferative breast lesion 51.54 11.64 36 104494 2115 64392087
Cervical spinal stenosis 51.07 11.64 35 104495 1994 64392208
Thrombosis 50.73 11.64 238 104292 70404 64323798
Injection site atrophy 50.38 11.64 20 104510 357 64393845
Somnolence 50.09 11.64 166 104364 203479 64190723
Paraparesis 49.76 11.64 43 104487 3459 64390743
Feeling abnormal 49.27 11.64 378 104152 133224 64260978
Hypomagnesaemia 48.57 11.64 3 104527 37373 64356829
Psoriasis 48.39 11.64 28 104502 71675 64322527
Meningioma benign 48.39 11.64 18 104512 267 64393935
Postoperative wound infection 48.31 11.64 71 104459 10265 64383937
Hip arthroplasty 47.30 11.64 106 104424 21245 64372957
Hospitalisation 47.13 11.64 32 104498 75175 64319027
Psoriatic arthropathy 47.03 11.64 7 104523 43274 64350928
Cervix carcinoma 46.80 11.64 32 104498 1816 64392386
Pregnancy 46.68 11.64 104 104426 20761 64373441
Ascites 46.64 11.64 21 104509 61980 64332222
Nerve compression 46.62 11.64 59 104471 7402 64386800
Surgery 46.47 11.64 125 104405 28088 64366114
Paralysis 46.24 11.64 74 104456 11521 64382681
Arthralgia 46.20 11.64 476 104054 441784 63952418
Dysgraphia 46.07 11.64 41 104489 3430 64390772
Serotonin syndrome 45.96 11.64 5 104525 39277 64354925
Tibia fracture 45.78 11.64 47 104483 4698 64389504
Pericarditis 45.75 11.64 22 104508 62494 64331708
Neuropathy peripheral 45.63 11.64 75 104455 117450 64276752
Depressed level of consciousness 45.48 11.64 39 104491 81397 64312805
Blood pressure systolic increased 45.38 11.64 12 104518 49441 64344761
Fatigue 45.18 11.64 1557 102973 747173 63647029
Lack of injection site rotation 45.15 11.64 18 104512 325 64393877
Erythema 44.29 11.64 155 104375 186915 64207287
Disease progression 44.12 11.64 103 104427 141577 64252625
Diplopia 43.49 11.64 118 104412 26647 64367555
Feeling cold 43.19 11.64 109 104421 23569 64370633
Basedow's disease 42.98 11.64 16 104514 238 64393964
Cytomegalovirus infection 42.85 11.64 5 104525 37194 64357008
Ataxia 42.75 11.64 104 104426 21980 64372222
Foot fracture 42.32 11.64 92 104438 18065 64376137
Neutralising antibodies positive 42.20 11.64 16 104514 251 64393951
Rash maculo-papular 42.05 11.64 12 104518 47014 64347188
Gallbladder disorder 41.66 11.64 88 104442 16942 64377260
Pain in extremity 41.54 11.64 706 103824 302379 64091823
Bone marrow failure 41.49 11.64 13 104517 47939 64346263
Pneumonitis 41.23 11.64 15 104515 50350 64343852
Injection site inflammation 40.69 11.64 37 104493 3184 64391018
Agitation 40.64 11.64 50 104480 88317 64305885
Injection site irritation 40.50 11.64 37 104493 3203 64390999
Primary progressive multiple sclerosis 40.43 11.64 12 104518 83 64394119
Pulmonary thrombosis 40.40 11.64 66 104464 10452 64383750
Muscle tightness 40.36 11.64 68 104462 11047 64383155
Mammoplasty 40.05 11.64 15 104515 227 64393975
Fibula fracture 40.04 11.64 36 104494 3052 64391150
Upper gastrointestinal haemorrhage 39.92 11.64 5 104525 35215 64358987
Hypervolaemia 39.79 11.64 7 104523 38278 64355924
Drug dependence 39.59 11.64 4 104526 33308 64360894
Injection site scab 39.34 11.64 16 104514 305 64393897
Haematochezia 39.29 11.64 30 104500 66343 64327859
Agraphia 39.28 11.64 10 104520 35 64394167
Nasal congestion 39.27 11.64 24 104506 59634 64334568
Constipation 39.11 11.64 215 104315 229122 64165080
Meniscus injury 38.97 11.64 48 104482 5859 64388343
Back disorder 38.80 11.64 63 104467 9927 64384275
Cholecystectomy 38.74 11.64 56 104474 7976 64386226
Papillary thyroid cancer 38.42 11.64 31 104499 2267 64391935
Sedation 38.16 11.64 10 104520 41452 64352750
Agranulocytosis 37.59 11.64 8 104522 38221 64355981
Haematuria 37.53 11.64 26 104504 60445 64333757
Breast cancer recurrent 37.28 11.64 32 104498 2551 64391651
Hypertonic bladder 36.92 11.64 36 104494 3382 64390820
Haemorrhage in pregnancy 36.84 11.64 24 104506 1256 64392946
Epistaxis 36.82 11.64 64 104466 98067 64296135
Vision blurred 36.39 11.64 261 104269 90055 64304147
Glioblastoma 36.29 11.64 25 104505 1436 64392766
Focal dyscognitive seizures 36.19 11.64 35 104495 3255 64390947
Osteoarthritis 36.10 11.64 200 104330 63136 64331066
Helicobacter infection 35.79 11.64 9 104521 38353 64355849
Appendicectomy 35.79 11.64 29 104501 2134 64392068
Cellulitis 35.65 11.64 267 104263 93390 64300812
Urosepsis 35.49 11.64 97 104433 21997 64372205
Blister 34.98 11.64 48 104482 80919 64313283
Rotator cuff syndrome 34.91 11.64 67 104463 12040 64382162
Meningioma 34.85 11.64 37 104493 3845 64390357
Colon cancer stage III 34.82 11.64 13 104517 195 64394007
Ruptured cerebral aneurysm 34.70 11.64 17 104513 510 64393692
Burning sensation 34.69 11.64 166 104364 49498 64344704
Medication error 34.45 11.64 19 104511 49947 64344255
Ovarian cyst 34.30 11.64 63 104467 10955 64383247
Retinal exudates 34.17 11.64 22 104508 1128 64393074
Delirium 34.14 11.64 37 104493 69157 64325045
Wound infection staphylococcal 34.11 11.64 32 104498 2865 64391337
Uterine cancer 34.11 11.64 32 104498 2866 64391336
Rectal haemorrhage 34.03 11.64 30 104500 61787 64332415
Shock 33.75 11.64 10 104520 38230 64355972
Brain neoplasm benign 33.70 11.64 12 104518 156 64394046
Thyroid disorder 32.86 11.64 64 104466 11628 64382574
Incorrect dose administered 32.84 11.64 30 104500 60735 64333467
Thyroid neoplasm 32.54 11.64 30 104500 2627 64391575
Ligament sprain 32.46 11.64 61 104469 10791 64383411
Endometrial cancer 32.43 11.64 26 104504 1884 64392318
No adverse event 32.40 11.64 111 104419 28450 64365752
Hepatic function abnormal 32.17 11.64 34 104496 64279 64329923
Hernia 32.08 11.64 69 104461 13449 64380753
Haemoptysis 31.91 11.64 20 104510 49028 64345174
Accidental exposure to product 31.77 11.64 3 104527 26361 64367841
Facial bones fracture 31.66 11.64 37 104493 4275 64389927
Malaise 31.55 11.64 853 103677 395394 63998808
Prolonged labour 31.51 11.64 15 104515 422 64393780
Breech presentation 31.48 11.64 17 104513 627 64393575
Mouth ulceration 31.48 11.64 7 104523 32437 64361765
Spinal fusion surgery 31.37 11.64 34 104496 3617 64390585
Tubulointerstitial nephritis 31.37 11.64 6 104524 30903 64363299
Arthritis 31.36 11.64 238 104292 83576 64310626
Colon cancer 31.36 11.64 66 104464 12673 64381529
Disseminated intravascular coagulation 31.34 11.64 7 104523 32341 64361861
Benign lung neoplasm 31.19 11.64 10 104520 92 64394110
Spinal disorder 31.19 11.64 53 104477 8669 64385533
Product administration error 31.14 11.64 4 104526 27639 64366563
Cholestasis 31.03 11.64 17 104513 44855 64349347
Band sensation 30.88 11.64 17 104513 652 64393550
Blindness 30.83 11.64 92 104438 21927 64372275
Mental impairment 30.61 11.64 76 104454 16267 64377935
Phobia 30.21 11.64 14 104516 370 64393832
Eosinophilia 30.07 11.64 12 104518 38064 64356138
Monoparesis 30.02 11.64 30 104500 2904 64391298
Movement disorder 29.94 11.64 91 104439 21909 64372293
Vein disorder 29.89 11.64 35 104495 4052 64390150
Procedural complication 29.84 11.64 47 104483 7218 64386984
Diplegia 29.66 11.64 23 104507 1588 64392614
JC polyomavirus test 29.66 11.64 8 104522 37 64394165
Dysarthria 29.57 11.64 181 104349 59225 64334977
Pollakiuria 29.40 11.64 115 104415 31415 64362787
Injection site nodule 29.38 11.64 31 104499 3199 64391003
Autoimmune hepatitis 29.32 11.64 56 104474 10028 64384174
Swelling 29.09 11.64 147 104383 160071 64234131
Acute respiratory failure 29.01 11.64 23 104507 49911 64344291
Suicidal ideation 28.98 11.64 196 104334 66346 64327856
Vertigo 28.87 11.64 179 104351 58832 64335370
Leukopenia 28.86 11.64 77 104453 101165 64293037
Skin laceration 28.67 11.64 96 104434 24321 64369881
Cellulitis staphylococcal 28.60 11.64 19 104511 1028 64393174
Product administered at inappropriate site 28.56 11.64 30 104500 3080 64391122
Frustration tolerance decreased 28.52 11.64 42 104488 6083 64388119
Gallbladder operation 28.50 11.64 23 104507 1682 64392520
Atrial fibrillation 28.28 11.64 162 104368 170927 64223275
Cardiac arrest 28.17 11.64 141 104389 153923 64240279
Product prescribing error 28.04 11.64 11 104519 35258 64358944
Rectocele 27.83 11.64 15 104515 551 64393651
Drug ineffective for unapproved indication 27.73 11.64 8 104522 31125 64363077
Wrist fracture 27.20 11.64 54 104476 9947 64384255
Rib fracture 26.89 11.64 93 104437 23945 64370257
Intervertebral disc operation 26.69 11.64 16 104514 722 64393480
Abnormal labour 26.69 11.64 6 104524 10 64394192
Cervical vertebral fracture 26.60 11.64 29 104501 3106 64391096
Cartilage injury 26.59 11.64 20 104510 1319 64392883
Hyperglycaemia 26.48 11.64 36 104494 60932 64333270
Chronic kidney disease 26.39 11.64 33 104497 57886 64336316
Hypercalcaemia 26.33 11.64 9 104521 31407 64362795
Folliculitis 26.30 11.64 8 104522 30069 64364133
Injection site discolouration 26.22 11.64 43 104487 6832 64387370
Blood urea increased 26.07 11.64 20 104510 44133 64350069
Product quality issue 25.92 11.64 8 104522 29791 64364411
Injection site injury 25.79 11.64 15 104515 640 64393562
Muscle atrophy 25.72 11.64 52 104478 9706 64384496
Paraplegia 25.70 11.64 34 104496 4456 64389746
Poor venous access 25.68 11.64 60 104470 12357 64381845
Dry skin 25.64 11.64 27 104503 51134 64343068
Sarcoidosis 25.58 11.64 40 104490 6106 64388096
Haemolytic uraemic syndrome 25.44 11.64 32 104498 3989 64390213
Chronic lymphocytic leukaemia 25.20 11.64 33 104497 4282 64389920
Abdominal distension 25.16 11.64 76 104454 95918 64298284
Clostridial infection 25.14 11.64 36 104494 5083 64389119
Volvulus 25.14 11.64 24 104506 2197 64392005
Oedema peripheral 25.04 11.64 219 104311 210098 64184104
Pulmonary sarcoidosis 24.95 11.64 18 104512 1113 64393089
Rash pruritic 24.83 11.64 34 104496 57370 64336832
Epilepsy 24.82 11.64 114 104416 33417 64360785
Blood potassium decreased 24.66 11.64 130 104400 40269 64353933
Obstructive airways disorder 24.62 11.64 4 104526 23181 64371021
Aphasia 24.54 11.64 131 104399 40775 64353427
Goitre 24.46 11.64 35 104495 4938 64389264
Decreased immune responsiveness 24.41 11.64 33 104497 4415 64389787
Central venous catheterisation 24.39 11.64 26 104504 2715 64391487
Depressed mood 24.37 11.64 131 104399 40881 64353321
Oestrogen receptor assay positive 24.30 11.64 11 104519 275 64393927
Varicose vein 24.26 11.64 30 104500 3677 64390525
Arterial occlusive disease 24.18 11.64 42 104488 6991 64387211
Orthostatic hypotension 24.18 11.64 24 104506 46714 64347488
Fluid retention 24.11 11.64 37 104493 59569 64334633
Drug intolerance 24.08 11.64 192 104338 187800 64206402
Autoimmune thyroiditis 23.81 11.64 29 104501 3499 64390703
Benign breast neoplasm 23.80 11.64 15 104515 741 64393461
Systemic lupus erythematosus 23.69 11.64 57 104473 77555 64316647
Stevens-Johnson syndrome 23.64 11.64 13 104517 34236 64359966
Brain neoplasm 23.51 11.64 34 104496 4844 64389358
Angioedema 23.48 11.64 40 104490 61781 64332421
Myoclonus 23.23 11.64 6 104524 25112 64369090
Muscle injury 23.17 11.64 7 104523 26430 64367772
Renal tubular necrosis 23.07 11.64 4 104526 22106 64372096
Progesterone receptor assay positive 22.98 11.64 10 104520 227 64393975
Withdrawal syndrome 22.93 11.64 5 104525 23487 64370715
Breast calcifications 22.85 11.64 15 104515 795 64393407
Fractured coccyx 22.76 11.64 16 104514 950 64393252
Anal incontinence 22.72 11.64 65 104465 15131 64379071
Thermal burn 22.60 11.64 37 104493 5869 64388333
Hepatocellular injury 22.52 11.64 24 104506 45211 64348991
Cervical dysplasia 22.44 11.64 21 104509 1875 64392327
Bladder dysfunction 22.40 11.64 16 104514 974 64393228
Post procedural stroke 22.40 11.64 8 104522 105 64394097
Pulmonary oedema 22.30 11.64 60 104470 78614 64315588
Haematemesis 22.24 11.64 26 104504 46973 64347229
COVID-19 22.22 11.64 45 104485 65095 64329107
Right ventricular failure 22.15 11.64 4 104526 21467 64372735
Anaphylactic reaction 22.11 11.64 49 104481 68615 64325587
Skull fracture 22.05 11.64 19 104511 1522 64392680
Blood calcium decreased 21.98 11.64 7 104523 25547 64368655
Mental disorder 21.92 11.64 93 104437 26352 64367850
Ectopic pregnancy 21.81 11.64 19 104511 1545 64392657
Overweight 21.77 11.64 27 104503 3319 64390883
Osteonecrosis 21.66 11.64 97 104433 28132 64366070
Colostomy closure 21.64 11.64 9 104521 182 64394020
Neuralgia 21.64 11.64 92 104438 26092 64368110
Crohn's disease 21.58 11.64 21 104509 1968 64392234
Blood cholesterol increased 21.52 11.64 147 104383 49919 64344283
Alopecia 21.32 11.64 169 104361 165521 64228681
Blood pressure diastolic decreased 21.26 11.64 5 104525 22296 64371906
Back injury 21.24 11.64 42 104488 7715 64386487
Blood pressure fluctuation 21.17 11.64 32 104498 51839 64342363
Retinal tear 21.14 11.64 17 104513 1237 64392965
Restlessness 21.08 11.64 20 104510 39765 64354437
Vaccination complication 21.06 11.64 13 104517 619 64393583
Bronchopulmonary aspergillosis 20.94 11.64 3 104527 19082 64375120
Ventricular tachycardia 20.91 11.64 15 104515 34250 64359952
Urinary tract infection staphylococcal 20.87 11.64 14 104516 770 64393432
Pelvic fracture 20.72 11.64 50 104480 10513 64383689
Spondylolisthesis 20.56 11.64 24 104506 2770 64391432
Female genital operation 20.48 11.64 5 104525 14 64394188
Rectal cancer 20.47 11.64 24 104506 2782 64391420
Renal cell carcinoma 20.40 11.64 36 104494 6068 64388134
Reaction to preservatives 20.30 11.64 8 104522 140 64394062
Cephalo-pelvic disproportion 20.04 11.64 8 104522 145 64394057
Enterocele 20.03 11.64 6 104524 43 64394159
Abortion missed 20.00 11.64 16 104514 1156 64393046
Tachypnoea 19.98 11.64 9 104521 26562 64367640
Intervertebral disc displacement 19.95 11.64 11 104519 423 64393779
Fear of injection 19.93 11.64 35 104495 5877 64388325
Magnetic resonance imaging head abnormal 19.92 11.64 22 104508 2390 64391812
Lumbar radiculopathy 19.91 11.64 19 104511 1738 64392464
Polyneuropathy 19.90 11.64 4 104526 19890 64374312
Pre-eclampsia 19.86 11.64 36 104494 6195 64388007
Breast cancer stage III 19.80 11.64 24 104506 2881 64391321
Encephalopathy 19.75 11.64 41 104489 58778 64335424
Carotid artery aneurysm 19.70 11.64 9 104521 230 64393972
Myelosuppression 19.67 11.64 7 104523 23823 64370379
Oral pain 19.62 11.64 10 104520 27483 64366719
Ophthalmoplegia 19.53 11.64 23 104507 2679 64391523
Incision site complication 19.51 11.64 13 104517 707 64393495
Benign neoplasm of spinal cord 19.47 11.64 4 104526 3 64394199
Rectal cancer stage I 19.47 11.64 4 104526 3 64394199
Cholecystitis 19.44 11.64 73 104457 19563 64374639
Clavicle fracture 19.35 11.64 27 104503 3722 64390480
Incision site abscess 19.31 11.64 9 104521 241 64393961
Medical induction of coma 19.25 11.64 7 104523 97 64394105
Spinal osteoarthritis 19.21 11.64 59 104471 14282 64379920
Scoliosis 19.21 11.64 35 104495 6047 64388155
Nerve injury 19.13 11.64 40 104490 7645 64386557
Foetal heart rate abnormal 19.11 11.64 9 104521 247 64393955
Fibrocystic breast disease 19.09 11.64 12 104518 590 64393612
Throat irritation 19.08 11.64 15 104515 32696 64361506
Limb mass 19.05 11.64 24 104506 2997 64391205
Expanded disability status scale score increased 19.05 11.64 11 104519 463 64393739
Malignant hypertension 19.01 11.64 17 104513 1431 64392771
Limb injury 18.97 11.64 82 104448 23423 64370779
Oral candidiasis 18.85 11.64 7 104523 23205 64370997
Oropharyngeal pain 18.83 11.64 77 104453 88790 64305412
Cardiogenic shock 18.75 11.64 15 104515 32412 64361790
Death 18.74 11.64 618 103912 482087 63912115
Lung carcinoma cell type unspecified stage IV 18.71 11.64 14 104516 916 64393286
Accident 18.66 11.64 37 104493 6809 64387393
Fat necrosis 18.64 11.64 13 104517 762 64393440
Atrophy 18.60 11.64 19 104511 1888 64392314
Urinary bladder suspension 18.57 11.64 7 104523 108 64394094
Schwannoma 18.51 11.64 7 104523 109 64394093
Panic attack 18.39 11.64 75 104455 20878 64373324
Heavy menstrual bleeding 18.39 11.64 52 104478 12025 64382177
Conversion disorder 18.37 11.64 18 104512 1701 64392501
Post procedural infection 18.37 11.64 45 104485 9552 64384650
Cholecystitis infective 18.35 11.64 22 104508 2611 64391591
Bladder prolapse 18.25 11.64 15 104515 1126 64393076
Glioblastoma multiforme 18.22 11.64 15 104515 1129 64393073
Therapy non-responder 18.12 11.64 51 104479 65848 64328354
Knee operation 18.05 11.64 29 104501 4528 64389674
Cardiac valve rupture 18.05 11.64 4 104526 6 64394196
Full blood count decreased 18.02 11.64 7 104523 22575 64371627
Respiratory distress 17.97 11.64 36 104494 52295 64341907
Hepatotoxicity 17.96 11.64 23 104507 39939 64354263
Loss of consciousness 17.94 11.64 339 104191 148026 64246176
Altered state of consciousness 17.89 11.64 21 104509 37881 64356321
Precancerous cells present 17.80 11.64 14 104516 987 64393215
Pain in jaw 17.76 11.64 24 104506 40731 64353471
Patella fracture 17.76 11.64 17 104513 1561 64392641
Injection site calcification 17.74 11.64 5 104525 28 64394174
Inappropriate antidiuretic hormone secretion 17.64 11.64 7 104523 22282 64371920
Femur fracture 17.62 11.64 105 104425 34030 64360172
Inflammation 17.61 11.64 51 104479 65249 64328953
Raynaud's phenomenon 17.61 11.64 14 104516 1002 64393200
Uterine disorder 17.53 11.64 18 104512 1799 64392403
Demyelination 17.52 11.64 36 104494 6798 64387404
Breast cancer metastatic 17.48 11.64 37 104493 7132 64387070
Red blood cell sedimentation rate increased 17.38 11.64 15 104515 31220 64362982
Hallucination, visual 17.22 11.64 12 104518 27822 64366380
Rash erythematous 17.10 11.64 33 104497 48600 64345602
Toxic skin eruption 17.09 11.64 5 104525 19279 64374923
Urinary retention postoperative 17.09 11.64 7 104523 136 64394066
Skin exfoliation 17.08 11.64 29 104501 44856 64349346
Gun shot wound 17.04 11.64 14 104516 1050 64393152
Product substitution issue 17.03 11.64 4 104526 17857 64376345
Heat stroke 17.00 11.64 16 104514 1439 64392763
Injection site swelling 16.93 11.64 120 104410 41233 64352969
Female sterilisation 16.90 11.64 8 104522 222 64393980
Contusion 16.87 11.64 269 104261 113696 64280506
Progressive relapsing multiple sclerosis 16.79 11.64 5 104525 35 64394167
Ovarian germ cell teratoma benign 16.79 11.64 5 104525 35 64394167
Fear 16.77 11.64 71 104459 20100 64374102
Skin cancer 16.73 11.64 50 104480 11924 64382278
Injection site fibrosis 16.71 11.64 4 104526 10 64394192
Colon cancer metastatic 16.68 11.64 18 104512 1905 64392297
Haemophagocytic lymphohistiocytosis 16.68 11.64 4 104526 17605 64376597
Circulatory collapse 16.68 11.64 18 104512 33714 64360488
Anuria 16.66 11.64 5 104525 18959 64375243
Intervertebral disc injury 16.63 11.64 7 104523 146 64394056
Hand fracture 16.62 11.64 29 104501 4845 64389357
Optic nerve disorder 16.58 11.64 14 104516 1091 64393111
Aggression 16.58 11.64 31 104499 46201 64348001
Skin graft 16.54 11.64 13 104517 915 64393287
Dystonia 16.52 11.64 5 104525 18860 64375342
Post procedural haemorrhage 16.52 11.64 51 104479 12380 64381822
Endometrial adenocarcinoma 16.49 11.64 13 104517 919 64393283
Complication of delivery 16.45 11.64 6 104524 84 64394118
Uterine leiomyosarcoma 16.44 11.64 4 104526 11 64394191
Weight increased 16.41 11.64 245 104285 213103 64181099
Motor dysfunction 16.38 11.64 48 104482 11325 64382877
Renal failure 16.37 11.64 202 104328 181486 64212716
Heat exhaustion 16.33 11.64 8 104522 240 64393962
Endometrial cancer stage I 16.33 11.64 7 104523 153 64394049
Adrenal insufficiency 16.32 11.64 8 104522 22479 64371723
Benign uterine neoplasm 16.28 11.64 3 104527 0 64394202
Alpha-1 anti-trypsin increased 16.28 11.64 3 104527 0 64394202
Neurological complication associated with device 16.28 11.64 3 104527 0 64394202
Biopsy bladder 16.28 11.64 3 104527 0 64394202
Non-small cell lung cancer stage I 16.18 11.64 4 104526 12 64394190
Purpura 16.18 11.64 4 104526 17242 64376960
Lipoatrophy 15.94 11.64 11 104519 634 64393568
Arthroscopy 15.92 11.64 10 104520 491 64393711
Transaminases increased 15.90 11.64 30 104500 44564 64349638
Hyperthermia 15.82 11.64 3 104527 15547 64378655
Febrile convulsion 15.80 11.64 12 104518 803 64393399
Gastric cyst 15.77 11.64 6 104524 95 64394107
Insomnia 15.73 11.64 426 104104 197410 64196792
Serum serotonin decreased 15.71 11.64 4 104526 14 64394188
Dry mouth 15.71 11.64 48 104482 60370 64333832
Ovarian cancer stage III 15.69 11.64 7 104523 169 64394033
Myelodysplastic syndrome 15.65 11.64 13 104517 27566 64366636
Dysgeusia 15.62 11.64 33 104497 47014 64347188
Feeling of body temperature change 15.58 11.64 28 104502 4786 64389416
Coronary artery disease 15.52 11.64 158 104372 60275 64333927
Amniotic fluid volume decreased 15.49 11.64 8 104522 269 64393933
Neoplasm malignant 15.45 11.64 80 104450 24608 64369594
Calculus bladder 15.38 11.64 14 104516 1206 64392996
Rales 15.36 11.64 3 104527 15226 64378976
Eye disorder 15.36 11.64 66 104464 18803 64375399
Sinus bradycardia 15.36 11.64 9 104521 22884 64371318
Rhinorrhoea 15.34 11.64 48 104482 59921 64334281
Paraganglion neoplasm 15.29 11.64 4 104526 16 64394186
Oophorectomy bilateral 15.29 11.64 4 104526 16 64394186
Emotional disorder 15.18 11.64 50 104480 12557 64381645
Ventricular fibrillation 15.15 11.64 10 104520 23850 64370352
Wound 15.14 11.64 68 104462 76409 64317793
Cast application 15.10 11.64 4 104526 17 64394185
Injection site hypoaesthesia 15.06 11.64 9 104521 404 64393798
Reproductive tract disorder 15.05 11.64 5 104525 52 64394150
JC polyomavirus test positive 14.98 11.64 14 104516 1248 64392954
Dyspepsia 14.96 11.64 73 104457 80239 64313963
Lyme disease 14.93 11.64 19 104511 2396 64391806
Myopathy 14.93 11.64 5 104525 17675 64376527
Hypoalbuminaemia 14.92 11.64 5 104525 17669 64376533
Face oedema 14.90 11.64 11 104519 24750 64369452
Animal bite 14.85 11.64 18 104512 2161 64392041
Blood bilirubin increased 14.77 11.64 46 104484 57507 64336695
Faeces discoloured 14.76 11.64 12 104518 25717 64368485
Hyperbilirubinaemia 14.71 11.64 8 104522 21197 64373005
Nephropathy toxic 14.71 11.64 5 104525 17509 64376693
Spinal fracture 14.68 11.64 56 104474 15118 64379084
Confusional state 14.67 11.64 317 104213 260827 64133375
Crying 14.64 11.64 68 104462 20022 64374180
Incontinence 14.63 11.64 48 104482 12033 64382169
Meningitis viral 14.61 11.64 16 104514 1722 64392480
Benign renal neoplasm 14.57 11.64 4 104526 20 64394182
Umbilical cord around neck 14.57 11.64 4 104526 20 64394182
Ovarian adenoma 14.51 11.64 7 104523 203 64393999
Neurofibroma 14.41 11.64 4 104526 21 64394181
Medical device removal 14.39 11.64 10 104520 583 64393619
Colon cancer stage I 14.33 11.64 5 104525 61 64394141
Joint dislocation 14.28 11.64 46 104484 11419 64382783
Cystitis pseudomonal 14.21 11.64 3 104527 3 64394199
Lhermitte's sign 14.21 11.64 3 104527 3 64394199
Glomerular filtration rate decreased 14.15 11.64 7 104523 19565 64374637
Uterine mass 14.14 11.64 7 104523 215 64393987
Staphylococcal abscess 14.10 11.64 12 104518 945 64393257
Injection site thrombosis 14.09 11.64 6 104524 129 64394073
Drug eruption 14.07 11.64 23 104507 36113 64358089
Postoperative thrombosis 14.00 11.64 6 104524 131 64394071
Anaesthetic complication 13.95 11.64 19 104511 2560 64391642
Drug delivery system malfunction 13.90 11.64 9 104521 466 64393736
Hepatic steatosis 13.90 11.64 92 104438 30915 64363287
Arnold-Chiari malformation 13.88 11.64 6 104524 134 64394068
Abdominal operation 13.87 11.64 9 104521 468 64393734
Eosinophil count increased 13.78 11.64 3 104527 14109 64380093
Shock haemorrhagic 13.74 11.64 5 104525 16786 64377416
B-cell lymphoma stage I 13.74 11.64 3 104527 4 64394198
Liver function test increased 13.74 11.64 18 104512 30952 64363250
Spinal cord disorder 13.72 11.64 15 104515 1611 64392591
Neutralising antibodies 13.69 11.64 4 104526 26 64394176
Transfusion 13.68 11.64 6 104524 17988 64376214
Intestinal cyst 13.68 11.64 6 104524 139 64394063
Bladder cancer 13.65 11.64 44 104486 10930 64383272
Intracranial hypotension 13.61 11.64 8 104522 348 64393854
Ocular hyperaemia 13.61 11.64 10 104520 22554 64371648
Superficial vein prominence 13.45 11.64 5 104525 74 64394128
Limb traumatic amputation 13.43 11.64 4 104526 28 64394174
Cardiac disorder 13.42 11.64 144 104386 55672 64338530
Anti-interferon antibody positive 13.35 11.64 3 104527 5 64394197
Wrong technique in product usage process 13.33 11.64 57 104473 64917 64329285
Cervical incompetence 13.29 11.64 9 104521 503 64393699
Viral pericarditis 13.27 11.64 5 104525 77 64394125
Aspergillus infection 13.20 11.64 5 104525 16374 64377828
Viral infection 13.16 11.64 102 104428 36038 64358164
Plasma cell myeloma 13.16 11.64 35 104495 46040 64348162
Cardiac failure acute 13.15 11.64 5 104525 16339 64377863
Optic atrophy 13.15 11.64 15 104515 1688 64392514
Hepatic encephalopathy 13.14 11.64 9 104521 21057 64373145
Abdominal pain upper 13.11 11.64 202 104328 174828 64219374
Ovarian cyst ruptured 13.11 11.64 11 104519 850 64393352
Transient ischaemic attack 13.06 11.64 119 104411 44063 64350139
Lung adenocarcinoma 13.03 11.64 32 104498 6801 64387401
Haemodynamic instability 12.97 11.64 4 104526 14908 64379294
Lung adenocarcinoma stage I 12.86 11.64 4 104526 33 64394169
Acute hepatic failure 12.84 11.64 14 104516 26098 64368104
Cystocele 12.79 11.64 10 104520 699 64393503
Invasive lobular breast carcinoma 12.78 11.64 9 104521 536 64393666
Fasciitis 12.76 11.64 10 104520 701 64393501
Dry eye 12.74 11.64 17 104513 29002 64365200
Chronic leukaemia 12.68 11.64 3 104527 7 64394195
Bipolar I disorder 12.68 11.64 15 104515 1756 64392446
Porphyria non-acute 12.64 11.64 10 104520 711 64393491
Lung disorder 12.60 11.64 53 104477 60647 64333555
Diabetic ketoacidosis 12.58 11.64 18 104512 29827 64364375
Liposarcoma 12.51 11.64 7 104523 277 64393925
Rubber sensitivity 12.50 11.64 13 104517 1319 64392883
Lung cancer metastatic 12.46 11.64 20 104510 3120 64391082
Eczema 12.45 11.64 18 104512 29702 64364500
Impaired self-care 12.45 11.64 17 104513 2296 64391906
Spinal laminectomy 12.44 11.64 9 104521 559 64393643
Blood alkaline phosphatase increased 12.40 11.64 48 104482 56231 64337971
Inappropriate schedule of product administration 12.39 11.64 93 104437 92193 64302009
Cystitis interstitial 12.37 11.64 12 104518 1120 64393082
Arterial therapeutic procedure 12.36 11.64 4 104526 38 64394164
Allergy to metals 12.34 11.64 8 104522 415 64393787
Urinary tract disorder 12.34 11.64 20 104510 3146 64391056
Central nervous system inflammation 12.34 11.64 6 104524 177 64394025
Hyperaesthesia 12.32 11.64 40 104490 9974 64384228
Erythema multiforme 12.31 11.64 5 104525 15696 64378506
Maternal exposure during pregnancy 12.25 11.64 221 104309 95663 64298539
Umbilical hernia 12.24 11.64 24 104506 4381 64389821
Ovarian neoplasm 12.23 11.64 9 104521 574 64393628
Gastric banding 12.09 11.64 4 104526 41 64394161
Immunology test abnormal 12.09 11.64 4 104526 41 64394161
Myelitis transverse 12.04 11.64 14 104516 1609 64392593
Hypovolaemia 12.03 11.64 5 104525 15481 64378721
Blood lactate dehydrogenase increased 12.02 11.64 22 104508 33056 64361146
Uterine cyst 12.01 11.64 7 104523 300 64393902
Renal surgery 12.01 11.64 4 104526 42 64394160
Cold type haemolytic anaemia 11.96 11.64 7 104523 302 64393900
Sensory loss 11.95 11.64 40 104490 10129 64384073
Liver function test abnormal 11.93 11.64 148 104382 59253 64334949
Ulcer haemorrhage 11.91 11.64 24 104506 4468 64389734
Colon cancer stage II 11.85 11.64 5 104525 105 64394097
Visual acuity reduced 11.85 11.64 80 104450 27061 64367141
Central nervous system infection 11.83 11.64 12 104518 1182 64393020
Breast cellulitis 11.80 11.64 7 104523 310 64393892
Premature labour 11.79 11.64 33 104497 7587 64386615
Basal cell carcinoma 11.77 11.64 88 104442 30750 64363452
Urine output decreased 11.77 11.64 6 104524 16486 64377716
Complication of pregnancy 11.76 11.64 7 104523 312 64393890
Aneurysm 11.75 11.64 19 104511 2983 64391219
Cerebral thrombosis 11.69 11.64 16 104514 2166 64392036
Prostate cancer stage II 11.69 11.64 9 104521 615 64393587
Lung infiltration 11.66 11.64 10 104520 20879 64373323
Partial seizures 11.65 11.64 32 104498 7275 64386927
Hemianaesthesia 11.65 11.64 8 104522 457 64393745

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC L03AB07 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
IMMUNOSTIMULANTS
IMMUNOSTIMULANTS
Interferons
FDA CS M0025715 Interferon-beta
MeSH PA D000276 Adjuvants, Immunologic
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000970 Antineoplastic Agents
MeSH PA D000998 Antiviral Agents
MeSH PA D007155 Immunologic Factors
FDA EPC N0000191625 Interferon beta

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Relapsing remitting multiple sclerosis indication 426373005 DOID:2378




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Interferon alpha/beta receptor Membrane receptor AGONIST DRUG LABEL DRUG LABEL

External reference:

IDSource
XRO4566Q4R UNII
4024025 VANDF
C0254119 UMLSCUI
CHEMBL1201562 ChEMBL_ID
D04554 KEGG_DRUG
DB00060 DRUGBANK_ID
CHEMBL2108510 ChEMBL_ID
D000068556 MESH_DESCRIPTOR_UI
153326 RXNORM
4895 MMSL
6144 MMSL
d04011 MMSL
108749003 SNOMEDCT_US
386902004 SNOMEDCT_US
005910 NDDF

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
REBIF HUMAN PRESCRIPTION DRUG LABEL 1 44087-0022 INJECTION, SOLUTION 22 ug SUBCUTANEOUS BLA 30 sections
REBIF HUMAN PRESCRIPTION DRUG LABEL 1 44087-0044 INJECTION, SOLUTION 44 ug SUBCUTANEOUS BLA 30 sections
REBIF REBIDOSE HUMAN PRESCRIPTION DRUG LABEL 1 44087-3322 INJECTION, SOLUTION 22 ug SUBCUTANEOUS BLA 30 sections
REBIF REBIDOSE HUMAN PRESCRIPTION DRUG LABEL 1 44087-3344 INJECTION, SOLUTION 44 ug SUBCUTANEOUS BLA 30 sections
Avonex HUMAN PRESCRIPTION DRUG LABEL 1 59627-002 INJECTION, SOLUTION 30 ug INTRAMUSCULAR BLA 28 sections
Avonex Pen HUMAN PRESCRIPTION DRUG LABEL 1 59627-003 INJECTION, SOLUTION 30 ug INTRAMUSCULAR BLA 28 sections