technetium Tc 99m medronate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
5120 121524-79-6

Description:

MoleculeDescription

Synonyms:

  • technetium Tc 99m medronate
  • osteolite
  • Technetium (99mTc) methylenediphosphonate
A radiopharmaceutical containing methylene diphosphonate (medronate; MDP) complexed with the gamma-emitting radionuclide technetium Tc 99m with radioisotopic activity and hydroxyapatite affinity. Upon intravenous administration, skeletal uptake of technetium Tc 99m methylene diphosphonate occurs as a function of skeletal blood flow and osteogenic activity. The MDP moiety of this agent has affinity for hydroxyapatite crystals in bone with abnormal accumulation at sites with increased osteoid mineralization; labeling of MDP with Tc 99m allows scintigraphic imaging of areas of abnormal osteogenesis associated with malignant bone lesions.
  • Molecular weight: 306.91
  • Formula: CH6O8P2Tc
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA: 149.32
  • ALOGS:
  • ROTB: None

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Dec. 16, 1977 FDA PHARMALUCENCE

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
FDA MoA N0000000205 Radiopharmaceutical Activity
MeSH PA D064907 Diagnostic Uses of Chemicals
MeSH PA D007202 Indicators and Reagents
MeSH PA D019275 Radiopharmaceuticals
FDA EPC N0000177914 Radioactive Diagnostic Agent

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Radioisotope scan of bone indication 41747008




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
X89XV46R07 UNII
D02029 KEGG_DRUG
C0039416 UMLSCUI
CHEBI:32186 CHEBI
CHEMBL1200415 ChEMBL_ID
CHEMBL1200931 ChEMBL_ID
131704315 PUBCHEM_CID
DB09138 DRUGBANK_ID
D013669 MESH_DESCRIPTOR_UI
1488818 RXNORM
96390006 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Kit for the Preparation of Technetium Tc 99M Medronate HUMAN PRESCRIPTION DRUG LABEL 1 45567-0040 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 20 mg INTRAVENOUS NDA 16 sections
Kit for the Preparation of Technetium Tc 99m Medronate HUMAN PRESCRIPTION DRUG LABEL 1 65857-505 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 20 mg INTRAVENOUS NDA 17 sections