technetium Tc 99m medronate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	5120	121524-79-6

Description:

Molecule	Description
Synonyms: technetium Tc 99m medronate osteolite Technetium (99mTc) methylenediphosphonate	A radiopharmaceutical containing methylene diphosphonate (medronate; MDP) complexed with the gamma-emitting radionuclide technetium Tc 99m with radioisotopic activity and hydroxyapatite affinity. Upon intravenous administration, skeletal uptake of technetium Tc 99m methylene diphosphonate occurs as a function of skeletal blood flow and osteogenic activity. The MDP moiety of this agent has affinity for hydroxyapatite crystals in bone with abnormal accumulation at sites with increased osteoid mineralization; labeling of MDP with Tc 99m allows scintigraphic imaging of areas of abnormal osteogenesis associated with malignant bone lesions. Molecular weight: 306.91 Formula: CH6O8P2Tc CLOGP: LIPINSKI: None HAC: None HDO: None TPSA: 149.32 ALOGS: ROTB: None

Molecule

Description

Synonyms:

technetium Tc 99m medronate
osteolite
Technetium (99mTc) methylenediphosphonate

A radiopharmaceutical containing methylene diphosphonate (medronate; MDP) complexed with the gamma-emitting radionuclide technetium Tc 99m with radioisotopic activity and hydroxyapatite affinity. Upon intravenous administration, skeletal uptake of technetium Tc 99m methylene diphosphonate occurs as a function of skeletal blood flow and osteogenic activity. The MDP moiety of this agent has affinity for hydroxyapatite crystals in bone with abnormal accumulation at sites with increased osteoid mineralization; labeling of MDP with Tc 99m allows scintigraphic imaging of areas of abnormal osteogenesis associated with malignant bone lesions.

Molecular weight: 306.91
Formula: CH6O8P2Tc
CLOGP:
LIPINSKI: None
HAC: None
HDO: None
TPSA: 149.32
ALOGS:
ROTB: None

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
Dec. 16, 1977	FDA	PHARMALUCENCE

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
FDA MoA	N0000000205	Radiopharmaceutical Activity
MeSH PA	D064907	Diagnostic Uses of Chemicals
MeSH PA	D007202	Indicators and Reagents
MeSH PA	D019275	Radiopharmaceuticals
FDA EPC	N0000177914	Radioactive Diagnostic Agent

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Radioisotope scan of bone	indication	41747008

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

ID	Source
X89XV46R07	UNII
D02029	KEGG_DRUG
C0039416	UMLSCUI
CHEBI:32186	CHEBI
CHEMBL1200415	ChEMBL_ID
CHEMBL1200931	ChEMBL_ID
16124	PUBCHEM_CID
DB09138	DRUGBANK_ID
D013669	MESH_DESCRIPTOR_UI
1488818	RXNORM
96390006	SNOMEDCT_US

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Kit for the Preparation of Technetium Tc 99M Medronate	HUMAN PRESCRIPTION DRUG LABEL	1	45567-0040	INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION	20 mg	INTRAVENOUS	NDA	16 sections
Kit for the Preparation of Technetium Tc 99m Medronate	HUMAN PRESCRIPTION DRUG LABEL	1	65857-505	INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION	20 mg	INTRAVENOUS	NDA	17 sections