carmofur 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
uridine derivatives used as antiviral agents and as antineoplastics	511	61422-45-5

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

1-hexylcarbamoyl-5-fluorouracil
carmofur
mifurol
yamaful

Molecular weight: 257.27
Formula: C11H16FN3O3
CLOGP: 2.55
LIPINSKI: 0
HAC: 6
HDO: 2
TPSA: 78.51
ALOGS: -3.72
ROTB: 5

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	L01BC04	ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS ANTINEOPLASTIC AGENTS ANTIMETABOLITES Pyrimidine analogues
MeSH PA	D000970	Antineoplastic Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Malignant tumor of colon	indication	363406005	DOID:219

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	6.55	acidic
pKa2	13.95	acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Cytochrome P450 2D6	Enzyme	P10635	CP2D6_HUMAN		IC50	5.30		DRUG MATRIX
Mitogen-activated protein kinase 3	Kinase	P27361	MK03_HUMAN		IC50	5.21		DRUG MATRIX
Acid ceramidase	Enzyme	Q13510	ASAH1_HUMAN		IC50	7.68		CHEMBL
Sulfide:quinone oxidoreductase, mitochondrial	Unclassified	Q9Y6N5	SQRD_HUMAN		IC50	4.70		CHEMBL
Fatty-acid amide hydrolase 1	Enzyme		FAAH1_RAT		IC50	7.60		CHEMBL
Acid ceramidase	Enzyme		ASAH1_RAT		IC50	7.54		CHEMBL
Replicase polyprotein 1ab	Enzyme		R1AB_SARS2		IC50	5.74		CHEMBL

External reference:

ID	Source
D01784	KEGG_DRUG
C0044401	UMLSCUI
CHEBI:31360	CHEBI
CHEMBL460499	ChEMBL_ID
DB09010	DRUGBANK_ID
C017367	MESH_SUPPLEMENTAL_RECORD_UI
2577	PUBCHEM_CID
5042	INN_ID
HA82M3RAB2	UNII
010893	NDDF

Pharmaceutical products:

None