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chromic chloride 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 5118 | 10025-73-7 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
Trivalent chromium is part of glucose tolerance factor, an activator of insulin-mediated reactions. Chromium helps to maintain normal glucose metabolism and peripheral nerve function.
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
None
ADMET properties:
None
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| June 26, 1986 | FDA | HOSPIRA |
FDA Adverse Event Reporting System (Female)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Obstructive defaecation | 74.36 | 63.49 | 10 | 723 | 260 | 90627454 |
| Stoma site dermatitis | 73.79 | 63.49 | 10 | 723 | 276 | 90627438 |
| Gastrointestinal stoma output abnormal | 69.95 | 63.49 | 10 | 723 | 410 | 90627304 |
| Stoma site inflammation | 63.84 | 63.49 | 10 | 723 | 764 | 90626950 |
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Obstructive defaecation | 76.40 | 59.02 | 10 | 742 | 252 | 110588295 |
| Stoma site dermatitis | 75.08 | 59.02 | 10 | 742 | 289 | 110588258 |
| Gastrointestinal stoma output abnormal | 71.40 | 59.02 | 10 | 742 | 422 | 110588125 |
| Stoma site inflammation | 62.66 | 59.02 | 10 | 742 | 1025 | 110587522 |
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| CHEBI has role | CHEBI:39143 | Lewis acid |
| CHEBI has role | CHEBI:139492 | sensitizers |
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
None
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Epidermal growth factor receptor | Kinase | IC50 | 5.53 | CHEMBL | |||||
| Tyrosine-protein kinase Fyn | Kinase | IC50 | 5.76 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| KB1PCR9DMW | UNII |
| D03479 | KEGG_DRUG |
| 4018528 | VANDF |
| 4018529 | VANDF |
| 4018530 | VANDF |
| C0055617 | UMLSCUI |
| CHEBI:53351 | CHEBI |
| CHEMBL1200528 | ChEMBL_ID |
| 24808 | PUBCHEM_CID |
| DB09129 | DRUGBANK_ID |
| C022990 | MESH_SUPPLEMENTAL_RECORD_UI |
| 21009 | RXNORM |
| 29 | MMSL |
| 4439 | MMSL |
| d04250 | MMSL |
| 000862 | NDDF |
| 007501 | NDDF |
| 10060-12-5 | SECONDARY_CAS_RN |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| CHROMIUM | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-4093 | INJECTION, SOLUTION | 4 ug | INTRAVENOUS | NDA | 20 sections |
| CHROMIUM | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-4093 | INJECTION, SOLUTION | 4 ug | INTRAVENOUS | NDA | 20 sections |
| Multitrace-5 | HUMAN PRESCRIPTION DRUG LABEL | 5 | 0517-8510 | INJECTION, SOLUTION | 20.50 ug | INTRAVENOUS | UNAPPROVED DRUG OTHER | 14 sections |
| Multitrace -4 Pediatric | HUMAN PRESCRIPTION DRUG LABEL | 4 | 0517-9203 | INJECTION, SOLUTION, CONCENTRATE | 5.12 ug | INTRAVENOUS | UNAPPROVED DRUG OTHER | 14 sections |
| CHROMIUM CHROMIC CHLORIDE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 51662-1415 | INJECTION, SOLUTION | 4 ug | INTRAVENOUS | NDA | 13 sections |
| CHROMIC CHLORIDE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 72819-235 | INJECTION, SOLUTION | 4 ug | INTRAVENOUS | ANDA | 12 sections |